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Chin-Lee Wu, PH.D., M.D.

TitleAssociate Professor of Pathology
InstitutionMassachusetts General Hospital
DepartmentPathology
AddressMassachusetts General Hospital
Pathology, Warren 2
55 Fruit St
Boston MA 02114
Phone617/726-2967
Fax617/724-7803

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Dong F, Yang P, Wang C, Wu S, Xiao Y, McDougal WS, Young RH, Wu CL. Architectural heterogeneity and cribriform pattern predict adverse clinical outcome for Gleason grade 4 prostatic adenocarcinoma. Am J Surg Pathol. 2013 Dec; 37(12):1855-61.
    View in: PubMed
  2. Yang CP, Cherng CH, Wu CT, Huang HY, Tao PL, Lee SO, Wong CS. Intrathecal Ultra-Low Dose Naloxone Enhances the Antihyperalgesic Effects of Morphine and Attenuates Tumor Necrosis Factor-a and Tumor Necrosis Factor-a Receptor 1 Expression in the Dorsal Horn of Rats with Partial Sciatic Nerve Transection. Anesth Analg. 2013 Dec; 117(6):1493-502.
    View in: PubMed
  3. Aizer AA, Paly JJ, Zietman AL, Nguyen PL, Beard CJ, Rao SK, Kaplan ID, Niemierko A, Hirsch MS, Wu CL, Olumi AF, Michaelson MD, D'Amico AV, Efstathiou JA. Models of Care and NCCN Guideline Adherence in Very-Low-Risk Prostate Cancer. J Natl Compr Canc Netw. 2013 Nov 1; 11(11):1364-72.
    View in: PubMed
  4. Olumi AF, Kaufman DS, Zietman A, Harisinghani MG, Wu CL. Case records of the Massachusetts General Hospital. Case 25-2013. A 71-year-old man with hematuria and a mass in the bladder. N Engl J Med. 2013 Aug 15; 369(7):660-7.
    View in: PubMed
  5. Mitin T, Hunt D, Shipley WU, Kaufman DS, Uzzo R, Wu CL, Buyyounouski MK, Sandler H, Zietman AL. Transurethral surgery and twice-daily radiation plus paclitaxel-cisplatin or fluorouracil-cisplatin with selective bladder preservation and adjuvant chemotherapy for patients with muscle invasive bladder cancer (RTOG 0233): a randomised multicentre phase 2 trial. Lancet Oncol. 2013 Aug; 14(9):863-72.
    View in: PubMed
  6. Cai C, Zhong WD, McDougal WS, Wu CL. A 32-gene risk index: a new prognostic approach for prostate cancer progression. Asian J Androl. 2013 Sep; 15(5):590-1.
    View in: PubMed
  7. Tse JY, Wu S, Shinagare SA, Lauwers GY, Yilmaz O, Wu CL, Deshpande V. Peutz-Jeghers syndrome: a critical look at colonic Peutz-Jeghers polyps. Mod Pathol. 2013 Sep; 26(9):1235-40.
    View in: PubMed
  8. Wirth GJ, Psutka SP, Chapin BF, Wu S, Wu CL, Dahl DM. Midterm oncological outcomes of laparoscopic vs open radical prostatectomy (RP). BJU Int. 2013 Jul; 112(2):190-7.
    View in: PubMed
  9. Chekaluk Y, Wu CL, Rosenberg J, Riester M, Dai Q, Lin S, Guo Y, McDougal WS, Kwiatkowski DJ. Identification of nine genomic regions of amplification in urothelial carcinoma, correlation with stage, and potential prognostic and therapeutic value. PLoS One. 2013; 8(4):e60927.
    View in: PubMed
  10. Wu CL, Schroeder BE, Ma XJ, Cutie CJ, Wu S, Salunga R, Zhang Y, Kattan MW, Schnabel CA, Erlander MG, McDougal WS. Development and validation of a 32-gene prognostic index for prostate cancer progression. Proc Natl Acad Sci U S A. 2013 Apr 9; 110(15):6121-6.
    View in: PubMed
  11. Guo Y, Chekaluk Y, Zhang J, Du J, Gray NS, Wu CL, Kwiatkowski DJ. TSC1 involvement in bladder cancer: diverse effects and therapeutic implications. J Pathol. 2013 May; 230(1):17-27.
    View in: PubMed
  12. Chang KC, Hsu CC, Liu SH, Su CC, Yen CC, Lee MJ, Chen KL, Ho TJ, Hung DZ, Wu CC, Lu TH, Su YC, Chen YW, Huang CF. Cadmium Induces Apoptosis in Pancreatic ß-Cells through a Mitochondria-Dependent Pathway: The Role of Oxidative Stress-Mediated c-Jun N-Terminal Kinase Activation. PLoS One. 2013; 8(2):e54374.
    View in: PubMed
  13. Miyamoto DT, Lee RJ, Stott SL, Ting DT, Wittner BS, Ulman M, Smas ME, Lord JB, Brannigan BW, Trautwein J, Bander NH, Wu CL, Sequist LV, Smith MR, Ramaswamy S, Toner M, Maheswaran S, Haber DA. Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer. Cancer Discov. 2012 Nov; 2(11):995-1003.
    View in: PubMed
  14. Aizer AA, Paly JJ, Zietman AL, Nguyen PL, Beard CJ, Rao SK, Kaplan ID, Niemierko A, Hirsch MS, Wu CL, Olumi AF, Michaelson MD, D'Amico AV, Efstathiou JA. Multidisciplinary care and pursuit of active surveillance in low-risk prostate cancer. J Clin Oncol. 2012 Sep 1; 30(25):3071-6.
    View in: PubMed
  15. Dong F, Wang C, Farris AB, Wu S, Lee H, Olumi AF, McDougal WS, Young RH, Wu CL. Impact on the clinical outcome of prostate cancer by the 2005 international society of urological pathology modified Gleason grading system. Am J Surg Pathol. 2012 Jun; 36(6):838-43.
    View in: PubMed
  16. Lu J, Wirth GJ, Wu S, Chen J, Dahl DM, Olumi AF, Young RH, McDougal WS, Wu CL. A close surgical margin after radical prostatectomy is an independent predictor of recurrence. J Urol. 2012 Jul; 188(1):91-7.
    View in: PubMed
  17. Kaufman DS, Zietman AL, McDougal WS, Dahl DM, Harisinghani MG, Wu CL. Case records of the Massachusetts General Hospital. Case 9-2012. A 67-year-old man with a persistently elevated PSA level. N Engl J Med. 2012 Mar 22; 366(12):1143-50.
    View in: PubMed
  18. Gershman B, Dahl DM, Olumi AF, Young RH, McDougal WS, Wu CL. Smaller prostate gland size and older age predict Gleason score upgrading. Urol Oncol. 2013 Oct; 31(7):1033-7.
    View in: PubMed
  19. Qin W, Bajaj V, Malinowska I, Lu X, MacConaill L, Wu CL, Kwiatkowski DJ. Angiomyolipoma have common mutations in TSC2 but no other common genetic events. PLoS One. 2011; 6(9):e24919.
    View in: PubMed
  20. Smith MR, Zietman AL, Finkelstein JS, Wu CL. Case records of the Massachusetts General Hospital. Case 16-2011. A 67-year-old man with recurrent prostate cancer. N Engl J Med. 2011 May 26; 364(21):2044-51.
    View in: PubMed
  21. DeFeo EM, Wu CL, McDougal WS, Cheng LL. A decade in prostate cancer: from NMR to metabolomics. Nat Rev Urol. 2011 Jun; 8(6):301-11.
    View in: PubMed
  22. Lee CH, Wu SB, Hong CH, Liao WT, Wu CY, Chen GS, Wei YH, Yu HS. Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. Am J Pathol. 2011 May; 178(5):2066-76.
    View in: PubMed
  23. Psutka SP, Feldman AS, Rodin D, Olumi AF, Wu CL, McDougal WS. Men with organ-confined prostate cancer and positive surgical margins develop biochemical failure at a similar rate to men with extracapsular extension. Urology. 2011 Jul; 78(1):121-5.
    View in: PubMed
  24. Kaufman DS, Zietman AL, Dahl DM, Harisinghani MG, Wu CL. Case records of the Massachusetts General Hospital. Case 5-2011. A 65-year-old man with hematuria after treatment for prostate cancer. N Engl J Med. 2011 Feb 17; 364(7):667-75.
    View in: PubMed
  25. Niu Y, Ge R, Hu L, Diaz C, Wang Z, Wu CL, Olumi AF. Reduced levels of 5-a reductase 2 in adult prostate tissue and implications for BPH therapy. Prostate. 2011 Sep; 71(12):1317-24.
    View in: PubMed
  26. Chen CL, Ke JY, Lin KC, Wang CJ, Wu CY, Liu WY. Anthropometric and fitness variables associated with bone mineral density and broadband ultrasound attenuation in ambulatory children with cerebral palsy. J Child Neurol. 2011 May; 26(5):552-9.
    View in: PubMed
  27. Wu CC, Pu YS, Wu HC, Yang CY, Chen YC. Reversed association between levels of prostate specific antigen and levels of blood cadmium and urinary cadmium. Chemosphere. 2011 May; 83(8):1188-91.
    View in: PubMed
  28. Tritos NA, Byrne TN, Wu CL, Klibanski A. A patient with diabetes insipidus, anterior hypopituitarism and pituitary stalk thickening. Nat Rev Endocrinol. 2011 Jan; 7(1):54-9.
    View in: PubMed
  29. Chen CL, Ke JY, Wang CJ, Wu KP, Wu CY, Wong AM. Factors associated with bone density in different skeletal regions in children with cerebral palsy of various motor severities. Dev Med Child Neurol. 2011 Feb; 53(2):131-6.
    View in: PubMed
  30. Hsu MJ, Wu CY, Chiang HH, Lai YL, Hung SL. PI3K/Akt signaling mediated apoptosis blockage and viral gene expression in oral epithelial cells during herpes simplex virus infection. Virus Res. 2010 Oct; 153(1):36-43.
    View in: PubMed
  31. Kaul D, Wu CL, Adkins CB, Jordan KW, Defeo EM, Habbel P, Peterson RT, McDougal WS, Pohl U, Cheng LL. Assessing prostate cancer growth with mRNA of spermine metabolic enzymes. Cancer Biol Ther. 2010 May; 9(9):736-42.
    View in: PubMed
  32. Maxeiner A, Adkins CB, Zhang Y, Taupitz M, Halpern EF, McDougal WS, Wu CL, Cheng LL. Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles. Prostate. 2010 May 15; 70(7):710-7.
    View in: PubMed
  33. Passer BJ, Cheema T, Zhou B, Wakimoto H, Zaupa C, Razmjoo M, Sarte J, Wu S, Wu CL, Noah JW, Li Q, Buolamwini JK, Yen Y, Rabkin SD, Martuza RL. Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication. Cancer Res. 2010 May 15; 70(10):3890-5.
    View in: PubMed
  34. Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S. Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci Transl Med. 2010 Mar 31; 2(25):25ra23.
    View in: PubMed
  35. Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL. Metabolomic imaging for human prostate cancer detection. Sci Transl Med. 2010 Jan 27; 2(16):16ra8.
    View in: PubMed
  36. McMahon GT, Blake MA, Wu CL. Case records of the Massachusetts General Hospital. Case 1-2010. A 75-year-old man with hypertension, hyperglycemia, and edema. N Engl J Med. 2010 Jan 14; 362(2):156-66.
    View in: PubMed
  37. Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W. Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations. Arch Pathol Lab Med. 2009 Dec; 133(12):1949-53.
    View in: PubMed
  38. Kubota K, Anjum R, Yu Y, Kunz RC, Andersen JN, Kraus M, Keilhack H, Nagashima K, Krauss S, Paweletz C, Hendrickson RC, Feldman AS, Wu CL, Rush J, Villén J, Gygi SP. Sensitive multiplexed analysis of kinase activities and activity-based kinase identification. Nat Biotechnol. 2009 Oct; 27(10):933-40.
    View in: PubMed
  39. Kaufman DS, McDougal WS, Harisinghani MG, Wu CL. Case records of the Massachusetts General Hospital. Case 30-2009. A 77-year-old man with recurrent transitional-cell carcinoma of the ureter. N Engl J Med. 2009 Sep 24; 361(13):1292-9.
    View in: PubMed
  40. Huang J, Wu S, Wu CL, Manning BD. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res. 2009 Aug 1; 69(15):6107-14.
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  41. Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One. 2009; 4(7):e6189.
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  42. Feldman AS, Banyard J, Wu CL, McDougal WS, Zetter BR. Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. Clin Cancer Res. 2009 Feb 1; 15(3):1024-31.
    View in: PubMed
  43. Lin KC, Huang YH, Hsieh YW, Wu CY. Potential predictors of motor and functional outcomes after distributed constraint-induced therapy for patients with stroke. Neurorehabil Neural Repair. 2009 May; 23(4):336-42.
    View in: PubMed
  44. Zhang H, Zhang Y, Duan HO, Kirley SD, Lin SX, McDougal WS, Xiao H, Wu CL. TIP30 is associated with progression and metastasis of prostate cancer. Int J Cancer. 2008 Aug 15; 123(4):810-6.
    View in: PubMed
  45. Barry MJ, Kaufman DS, Wu CL. Case records of the Massachusetts General Hospital. Case 15-2008. A 55-year-old man with an elevated prostate-specific antigen level and early-stage prostate cancer. N Engl J Med. 2008 May 15; 358(20):2161-8.
    View in: PubMed
  46. Lin KC, Wu CY, Chen CL, Chern JS, Hong WH. Effects of object use on reaching and postural balance: a comparison of patients with unilateral stroke and healthy controls. Am J Phys Med Rehabil. 2007 Oct; 86(10):791-9.
    View in: PubMed
  47. Li W, Wu CL, Febbo PG, Olumi AF. Stromally expressed c-Jun regulates proliferation of prostate epithelial cells. Am J Pathol. 2007 Oct; 171(4):1189-98.
    View in: PubMed
  48. Dahl DM, He W, Lazarus R, McDougal WS, Wu CL. Pathologic outcome of laparoscopic and open radical prostatectomy. Urology. 2006 Dec; 68(6):1253-6.
    View in: PubMed
  49. Klibanski A, Stephen AE, Greene MF, Blake MA, Wu CL. Case records of the Massachusetts General Hospital. Case 36-2006. A 35-year-old pregnant woman with new hypertension. N Engl J Med. 2006 Nov 23; 355(21):2237-45.
    View in: PubMed
  50. Lu CH, Liu JY, Lee MS, Borel CO, Yeh CC, Wong CS, Wu CT. Preoperative cotreatment with dextromethorphan and ketorolac provides an enhancement of pain relief after laparoscopic-assisted vaginal hysterectomy. Clin J Pain. 2006 Nov-Dec; 22(9):799-804.
    View in: PubMed
  51. Lin L, Shi Q, Nyarko AK, Bastow KF, Wu CC, Su CY, Shih CC, Lee KH. Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents. J Med Chem. 2006 Jun 29; 49(13):3963-72.
    View in: PubMed
  52. Zhang H, Duan HO, Kirley SD, Zukerberg LR, Wu CL. Aberrant splicing of cables gene, a CDK regulator, in human cancers. Cancer Biol Ther. 2005 Nov; 4(11):1211-5.
    View in: PubMed
  53. Burns MA, Taylor JL, Wu CL, Zepeda AG, Bielecki A, Cory D, Cheng LL. Reduction of spinning sidebands in proton NMR of human prostate tissue with slow high-resolution magic angle spinning. Magn Reson Med. 2005 Jul; 54(1):34-42.
    View in: PubMed
  54. Chakravarti A, Winter K, Wu CL, Kaufman D, Hammond E, Parliament M, Tester W, Hagan M, Grignon D, Heney N, Pollack A, Sandler H, Shipley W. Expression of the epidermal growth factor receptor and Her-2 are predictors of favorable outcome and reduced complete response rates, respectively, in patients with muscle-invading bladder cancers treated by concurrent radiation and cisplatin-based chemotherapy: a report from the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 2005 Jun 1; 62(2):309-17.
    View in: PubMed
  55. Kohane DS, Ingelfinger JR, Nimkin K, Wu CL. Case records of the Massachusetts General Hospital. Case 16-2005. A nine-year-old girl with headaches and hypertension. N Engl J Med. 2005 May 26; 352(21):2223-31.
    View in: PubMed
  56. Cheng LL, Burns MA, Taylor JL, He W, Halpern EF, McDougal WS, Wu CL. Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy. Cancer Res. 2005 Apr 15; 65(8):3030-4.
    View in: PubMed
  57. Dluhy RG, Maher MM, Wu CL. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-2005. A 59-year-old woman with an incidentally discovered adrenal nodule. N Engl J Med. 2005 Mar 10; 352(10):1025-32.
    View in: PubMed
  58. Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, Thadhani R, Bonventre JV. Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol. 2005 Apr; 16(4):1126-34.
    View in: PubMed
  59. Burns MA, He W, Wu CL, Cheng LL. Quantitative pathology in tissue MR spectroscopy based human prostate metabolomics. Technol Cancer Res Treat. 2004 Dec; 3(6):591-8.
    View in: PubMed
  60. Jiang Z, Woda BA, Wu CL, Yang XJ. Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S). Am J Clin Pathol. 2004 Aug; 122(2):275-89.
    View in: PubMed
  61. Wu CL, Yang XJ, Tretiakova M, Patton KT, Halpern EF, Woda BA, Young RH, Jiang Z. Analysis of alpha-methylacyl-CoA racemase (P504S) expression in high-grade prostatic intraepithelial neoplasia. Hum Pathol. 2004 Aug; 35(8):1008-13.
    View in: PubMed
  62. Wu CL, Taylor JL, He W, Zepeda AG, Halpern EF, Bielecki A, Gonzalez RG, Cheng LL. Proton high-resolution magic angle spinning NMR analysis of fresh and previously frozen tissue of human prostate. Magn Reson Med. 2003 Dec; 50(6):1307-11.
    View in: PubMed
  63. Taylor JL, Wu CL, Cory D, Gonzalez RG, Bielecki A, Cheng LL. High-resolution magic angle spinning proton NMR analysis of human prostate tissue with slow spinning rates. Magn Reson Med. 2003 Sep; 50(3):627-32.
    View in: PubMed
  64. Tan D, Kirley S, Li Q, Ramnath N, Slocum HK, Brooks JS, Wu CL, Zukerberg LR. Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study. Hum Pathol. 2003 Feb; 34(2):143-9.
    View in: PubMed
  65. Jiang Z, Wu CL, Woda BA, Dresser K, Xu J, Fanger GR, Yang XJ. P504S/alpha-methylacyl-CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy. Am J Surg Pathol. 2002 Sep; 26(9):1169-74.
    View in: PubMed
  66. Yang XJ, Wu CL, Woda BA, Dresser K, Tretiakova M, Fanger GR, Jiang Z. Expression of alpha-Methylacyl-CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostate. Am J Surg Pathol. 2002 Jul; 26(7):921-5.
    View in: PubMed
  67. McGill TJ, Wu CL. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 19-2002. A 13-year-old girl with a mass in the left parotid gland and regional lymph nodes. N Engl J Med. 2002 Jun 20; 346(25):1989-96.
    View in: PubMed
  68. Schmidtko J, Wang R, Wu CL, Mauiyyedi S, Harris NL, Della Pelle P, Brousaides N, Zagachin L, Ferry JA, Wang F, Kawai T, Sachs DH, Cosimi BA, Colvin RB. Posttransplant lymphoproliferative disorder associated with an Epstein-Barr-related virus in cynomolgus monkeys. Transplantation. 2002 May 15; 73(9):1431-9.
    View in: PubMed
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