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Karen Inouye, Ph.D.

TitleResearch Associate
InstitutionHarvard School of Public Health
DepartmentGenetics and Complex Diseases
AddressHarvard School of Public Health
GDC, Bldg 1, Rm 610
665 Huntington Ave
Boston MA 02115
Phone617/432-1955

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie AN, Lee CH. Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest. 2013 Jan 2; 123(1):261-71.
    View in: PubMed
  2. Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 30; 488(7413):670-4.
    View in: PubMed
  3. Inouye KE, Chan O, Yue JT, Andrews M, Li Q, Matthews SG, Vranic M. The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats. Brain Res Bull. 2008 Oct 22; 77(4):149-57.
    View in: PubMed
  4. Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, Rollins BJ, Flier JS. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes. 2007 Sep; 56(9):2242-50.
    View in: PubMed
  5. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006 Nov; 116(11):3015-25.
    View in: PubMed
  6. Shi H, Cave B, Inouye K, Bjørbaek C, Flier JS. Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes. 2006 Mar; 55(3):699-707.
    View in: PubMed
  7. Inouye KE, Yue JT, Chan O, Kim T, Akirav EM, Park E, Riddell MC, Burdett E, Matthews SG, Vranic M. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Endocrinology. 2006 Apr; 147(4):1860-70.
    View in: PubMed
  8. Chan O, Inouye K, Akirav EM, Park E, Riddell MC, Matthews SG, Vranic M. Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2005 Jul; 289(1):R235-46.
    View in: PubMed
  9. Akirav EM, Chan O, Inouye K, Riddell MC, Matthews SG, Vranic M. Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats. Metabolism. 2004 Dec; 53(12):1558-64.
    View in: PubMed
  10. Chan O, Inouye K, Akirav E, Park E, Riddell MC, Vranic M, Matthews SG. Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses. Endocrinology. 2005 Mar; 146(3):1382-90.
    View in: PubMed
  11. Inouye KE, Chan O, Yue JT, Matthews SG, Vranic M. Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis. Am J Physiol Endocrinol Metab. 2005 Feb; 288(2):E422-9.
    View in: PubMed
  12. Inouye K, Shum K, Chan O, Mathoo J, Matthews SG, Vranic M. Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats. Am J Physiol Endocrinol Metab. 2002 Jun; 282(6):E1369-79.
    View in: PubMed
  13. Chan O, Chan S, Inouye K, Shum K, Matthews SG, Vranic M. Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses. Diabetes. 2002 Jun; 51(6):1681-9.
    View in: PubMed
  14. Chan O, Inouye K, Vranic M, Matthews SG. Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity. Endocrinology. 2002 May; 143(5):1761-8.
    View in: PubMed
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