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Gerhard Wagner, PH.D.

TitleElkan Blout Professor of Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
AddressDept. of Bio Chem & Mol Pharm
Bcmp
240 Longwood Ave
Boston MA 02115
Phone617/432-3213
Fax617/432-4383

 Mentoring 
 completed student projects
Structural Basis of CD2 Signal Transduction Studied by NMR Spectroscopy
Summer, 06/01/99 - 07/30/99

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Wagner Laboratory - Instruments (30), Plasmids (23) and Software (37)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wagner G, Chiu W. Exploring new limits in complex biological structures. Curr Opin Struct Biol. 2013 Oct; 23(5):704-6.
    View in: PubMed
  2. Akabayov SR, Akabayov B, Richardson CC, Wagner G. Molecular Crowding Enhanced ATPase Activity of the RNA Helicase eIF4A Correlates with Compaction of Its Quaternary Structure and Association with eIF4G. J Am Chem Soc. 2013 Jul 10; 135(27):10040-7.
    View in: PubMed
  3. Yi T, Papadopoulos E, Hagner PR, Wagner G. Hypoxia-inducible Factor-1a (HIF-1a) Promotes Cap-dependent Translation of Selective mRNAs through Up-regulating Initiation Factor eIF4E1 in Breast Cancer Cells under Hypoxia Conditions. J Biol Chem. 2013 Jun 28; 288(26):18732-42.
    View in: PubMed
  4. Akabayov B, Akabayov SR, Lee SJ, Wagner G, Richardson CC. Impact of macromolecular crowding on DNA replication. Nat Commun. 2013 Mar 19; 4:1615.
    View in: PubMed
  5. Etzkorn M, Raschle T, Hagn F, Gelev V, Rice AJ, Walz T, Wagner G. Cell-free Expressed Bacteriorhodopsin in Different Soluble Membrane Mimetics: Biophysical Properties and NMR Accessibility. Structure. 2013 Mar 5; 21(3):394-401.
    View in: PubMed
  6. Hagn F, Etzkorn M, Raschle T, Wagner G. Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins. J Am Chem Soc. 2013 Feb 6; 135(5):1919-25.
    View in: PubMed
  7. Hyberts SG, Robson SA, Wagner G. Exploring signal-to-noise ratio and sensitivity in non-uniformly sampled multi-dimensional NMR spectra. J Biomol NMR. 2013 Feb; 55(2):167-78.
    View in: PubMed
  8. Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, O'Day EM, Yi T, Marintchev A, Hinnebusch AG, Lorsch JR, Asano K, Wagner G. The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2ß. Cell Rep. 2012 Jun 28; 1(6):689-702.
    View in: PubMed
  9. Kim ST, Shin Y, Brazin K, Mallis RJ, Sun ZY, Wagner G, Lang MJ, Reinherz EL. TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling. Front Immunol. 2012; 3:76.
    View in: PubMed
  10. Hyberts SG, Milbradt AG, Wagner AB, Arthanari H, Wagner G. Application of iterative soft thresholding for fast reconstruction of NMR data non-uniformly sampled with multidimensional Poisson Gap scheduling. J Biomol NMR. 2012 Apr; 52(4):315-27.
    View in: PubMed
  11. Hyberts SG, Arthanari H, Wagner G. Applications of non-uniform sampling and processing. Top Curr Chem. 2012; 316:125-48.
    View in: PubMed
  12. Yu TY, Raschle T, Hiller S, Wagner G. Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs. Biochim Biophys Acta. 2012 Jun; 1818(6):1562-9.
    View in: PubMed
  13. Gal M, Edmonds KA, Milbradt AG, Takeuchi K, Wagner G. Speeding up direct (15)N detection: hCaN 2D NMR experiment. J Biomol NMR. 2011 Dec; 51(4):497-504.
    View in: PubMed
  14. Narayanan S, Arthanari H, Wolfe MS, Wagner G. Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. J Biol Chem. 2011 Dec 23; 286(51):44266-76.
    View in: PubMed
  15. Fahmy A, Wagner G. Optimization of van der Waals energy for protein side-chain placement and design. Biophys J. 2011 Oct 5; 101(7):1690-8.
    View in: PubMed
  16. Milbradt AG, Kulkarni M, Yi T, Takeuchi K, Sun ZY, Luna RE, Selenko P, Näär AM, Wagner G. Structure of the VP16 transactivator target in the Mediator. Nat Struct Mol Biol. 2011 Apr; 18(4):410-5.
    View in: PubMed
  17. Arthanari H, Wagner G, Khaneja N. Heteronuclear decoupling by multiple rotating frame technique. J Magn Reson. 2011 Mar; 209(1):8-18.
    View in: PubMed
  18. Takeuchi K, Gal M, Takahashi H, Shimada I, Wagner G. HNCA-TOCSY-CANH experiments with alternate (13)C- (12)C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment. J Biomol NMR. 2011 Jan; 49(1):17-26.
    View in: PubMed
  19. Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 2010 Sep 17; 329(5998):1492-9.
    View in: PubMed
  20. Hiller S, Abramson J, Mannella C, Wagner G, Zeth K. The 3D structures of VDAC represent a native conformation. Trends Biochem Sci. 2010 Sep; 35(9):514-21.
    View in: PubMed
  21. Raschle T, Hiller S, Etzkorn M, Wagner G. Nonmicellar systems for solution NMR spectroscopy of membrane proteins. Curr Opin Struct Biol. 2010 Aug; 20(4):471-9.
    View in: PubMed
  22. Takeuchi K, Sun ZY, Park S, Wagner G. Autoinhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity. Biochemistry. 2010 Jul 13; 49(27):5634-41.
    View in: PubMed
  23. Takeuchi K, Heffron G, Sun ZY, Frueh DP, Wagner G. Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments. J Biomol NMR. 2010 Aug; 47(4):271-82.
    View in: PubMed
  24. Takeuchi K, Frueh DP, Sun ZY, Hiller S, Wagner G. CACA-TOCSY with alternate 13C-12C labeling: a 13Calpha direct detection experiment for mainchain resonance assignment, dihedral angle information, and amino acid type identification. J Biomol NMR. 2010 May; 47(1):55-63.
    View in: PubMed
  25. Takeuchi K, Frueh DP, Hyberts SG, Sun ZY, Wagner G. High-resolution 3D CANCA NMR experiments for complete mainchain assignments using C(alpha) direct detection. J Am Chem Soc. 2010 Mar 10; 132(9):2945-51.
    View in: PubMed
  26. Hyberts SG, Takeuchi K, Wagner G. Poisson-gap sampling and forward maximum entropy reconstruction for enhancing the resolution and sensitivity of protein NMR data. J Am Chem Soc. 2010 Feb 24; 132(7):2145-7.
    View in: PubMed
  27. Raschle T, Hiller S, Yu TY, Rice AJ, Walz T, Wagner G. Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. J Am Chem Soc. 2009 Dec 16; 131(49):17777-9.
    View in: PubMed
  28. Hiller S, Malia TJ, Garces RG, Orekhov VY, Wagner G. Backbone and ILV side chain methyl group assignments of the integral human membrane protein VDAC-1. Biomol NMR Assign. 2010 Apr; 4(1):29-32.
    View in: PubMed
  29. Frueh DP, Leed A, Arthanari H, Koglin A, Walsh CT, Wagner G. Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in (15)N-(13)C-ILV methyl labeled proteins. J Biomol NMR. 2009 Nov; 45(3):311-8.
    View in: PubMed
  30. Hiller S, Ibraghimov I, Wagner G, Orekhov VY. Coupled decomposition of four-dimensional NOESY spectra. J Am Chem Soc. 2009 Sep 16; 131(36):12970-8.
    View in: PubMed
  31. Frueh DP, Arthanari H, Koglin A, Walsh CT, Wagner G. A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins. J Am Chem Soc. 2009 Sep 16; 131(36):12880-1.
    View in: PubMed
  32. Kim ST, Takeuchi K, Sun ZY, Touma M, Castro CE, Fahmy A, Lang MJ, Wagner G, Reinherz EL. The alphabeta T cell receptor is an anisotropic mechanosensor. J Biol Chem. 2009 Nov 6; 284(45):31028-37.
    View in: PubMed
  33. Hyberts SG, Frueh DP, Arthanari H, Wagner G. FM reconstruction of non-uniformly sampled protein NMR data at higher dimensions and optimization by distillation. J Biomol NMR. 2009 Nov; 45(3):283-94.
    View in: PubMed
  34. Hiller S, Wagner G. The role of solution NMR in the structure determinations of VDAC-1 and other membrane proteins. Curr Opin Struct Biol. 2009 Aug; 19(4):396-401.
    View in: PubMed
  35. Hiller S, Arthanari H, Wagner G. The T-lock: automated compensation of radio-frequency induced sample heating. J Biomol NMR. 2009 Jun; 44(2):69-76.
    View in: PubMed
  36. Marintchev A, Edmonds KA, Marintcheva B, Hendrickson E, Oberer M, Suzuki C, Herdy B, Sonenberg N, Wagner G. Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell. 2009 Feb 6; 136(3):447-60.
    View in: PubMed
  37. Hemond M, Rothstein TL, Wagner G. Fas apoptosis inhibitory molecule contains a novel beta-sandwich in contact with a partially ordered domain. J Mol Biol. 2009 Mar 6; 386(4):1024-37.
    View in: PubMed
  38. Takeuchi K, Sun ZY, Wagner G. Alternate 13C-12C labeling for complete mainchain resonance assignments using C alpha direct-detection with applicability toward fast relaxing protein systems. J Am Chem Soc. 2008 Dec 24; 130(51):17210-1.
    View in: PubMed
  39. Hiller S, Garces RG, Malia TJ, Orekhov VY, Colombini M, Wagner G. Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science. 2008 Aug 29; 321(5893):1206-10.
    View in: PubMed
  40. Frueh DP, Arthanari H, Koglin A, Vosburg DA, Bennett AE, Walsh CT, Wagner G. Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature. 2008 Aug 14; 454(7206):903-6.
    View in: PubMed
  41. Koglin A, Löhr F, Bernhard F, Rogov VV, Frueh DP, Strieter ER, Mofid MR, Güntert P, Wagner G, Walsh CT, Marahiel MA, Dötsch V. Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature. 2008 Aug 14; 454(7206):907-11.
    View in: PubMed
  42. Kang S, Kang J, Kwon H, Frueh D, Yoo SH, Wagner G, Park S. Effects of redox potential and Ca2+ on the inositol 1,4,5-trisphosphate receptor L3-1 loop region: implications for receptor regulation. J Biol Chem. 2008 Sep 12; 283(37):25567-75.
    View in: PubMed
  43. Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, Reinherz EL, Wagner G. Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. J Mol Biol. 2008 Jul 18; 380(4):704-16.
    View in: PubMed
  44. Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Näär AM. A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature. 2008 Apr 3; 452(7187):604-9.
    View in: PubMed
  45. Selenko P, Frueh DP, Elsaesser SJ, Haas W, Gygi SP, Wagner G. In situ observation of protein phosphorylation by high-resolution NMR spectroscopy. Nat Struct Mol Biol. 2008 Mar; 15(3):321-9.
    View in: PubMed
  46. Suzuki C, Garces RG, Edmonds KA, Hiller S, Hyberts SG, Marintchev A, Wagner G. PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc Natl Acad Sci U S A. 2008 Mar 4; 105(9):3274-9.
    View in: PubMed
  47. Marintcheva B, Marintchev A, Wagner G, Richardson CC. Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1855-60.
    View in: PubMed
  48. Sun ZY, Oh KJ, Kim M, Yu J, Brusic V, Song L, Qiao Z, Wang JH, Wagner G, Reinherz EL. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity. 2008 Jan; 28(1):52-63.
    View in: PubMed
  49. Reibarkh M, Yamamoto Y, Singh CR, del Rio F, Fahmy A, Lee B, Luna RE, Ii M, Wagner G, Asano K. Eukaryotic initiation factor (eIF) 1 carries two distinct eIF5-binding faces important for multifactor assembly and AUG selection. J Biol Chem. 2008 Jan 11; 283(2):1094-103.
    View in: PubMed
  50. Tsodikov OV, Ivanov D, Orelli B, Staresincic L, Shoshani I, Oberman R, Schärer OD, Wagner G, Ellenberger T. Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA. EMBO J. 2007 Nov 14; 26(22):4768-76.
    View in: PubMed
  51. Catic A, Sun ZY, Ratner DM, Misaghi S, Spooner E, Samuelson J, Wagner G, Ploegh HL. Sequence and structure evolved separately in a ribosomal ubiquitin variant. EMBO J. 2007 Jul 25; 26(14):3474-83.
    View in: PubMed
  52. Zhong W, Dixit SB, Mallis RJ, Arthanari H, Lugovskoy AA, Beveridge DL, Wagner G, Reinherz EL. CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. J Mol Biol. 2007 Sep 14; 372(2):535-48.
    View in: PubMed
  53. Takeuchi K, Roehrl MH, Sun ZY, Wagner G. Structure of the calcineurin-NFAT complex: defining a T cell activation switch using solution NMR and crystal coordinates. Structure. 2007 May; 15(5):587-97.
    View in: PubMed
  54. Selenko P, Wagner G. Looking into live cells with in-cell NMR spectroscopy. J Struct Biol. 2007 May; 158(2):244-53.
    View in: PubMed
  55. Hyberts SG, Heffron GJ, Tarragona NG, Solanky K, Edmonds KA, Luithardt H, Fejzo J, Chorev M, Aktas H, Colson K, Falchuk KH, Halperin JA, Wagner G. Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction. J Am Chem Soc. 2007 Apr 25; 129(16):5108-16.
    View in: PubMed
  56. Takeuchi K, Ng E, Malia TJ, Wagner G. 1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins. J Biomol NMR. 2007 May; 38(1):89-98.
    View in: PubMed
  57. Touma M, Sun ZY, Clayton LK, Marissen WE, Kruisbeek AM, Wagner G, Reinherz EL. Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly. J Immunol. 2007 Mar 15; 178(6):3668-79.
    View in: PubMed
  58. Ivanov D, Tsodikov OV, Kasanov J, Ellenberger T, Wagner G, Collins T. Domain-swapped dimerization of the HIV-1 capsid C-terminal domain. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4353-8.
    View in: PubMed
  59. Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26; 128(2):257-67.
    View in: PubMed
  60. Malia TJ, Wagner G. NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL. Biochemistry. 2007 Jan 16; 46(2):514-25.
    View in: PubMed
  61. Marintchev A, Frueh D, Wagner G. NMR methods for studying protein-protein interactions involved in translation initiation. Methods Enzymol. 2007; 430:283-331.
    View in: PubMed
  62. Reibarkh M, Malia TJ, Hopkins BT, Wagner G. Identification of individual protein-ligand NOEs in the limit of intermediate exchange. J Biomol NMR. 2006 Sep; 36(1):1-11.
    View in: PubMed
  63. Gelev V, Aktas H, Marintchev A, Ito T, Frueh D, Hemond M, Rovnyak D, Debus M, Hyberts S, Usheva A, Halperin J, Wagner G. Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol. 2006 Dec 1; 364(3):352-63.
    View in: PubMed
  64. Sastry M, Brown C, Wagner G, Clark TD. Cyclic peptide helices: a hybrid beta-hairpin/beta-helical supersecondary structure. J Am Chem Soc. 2006 Aug 23; 128(33):10650-1.
    View in: PubMed
  65. Selenko P, Serber Z, Gadea B, Ruderman J, Wagner G. Quantitative NMR analysis of the protein G B1 domain in Xenopus laevis egg extracts and intact oocytes. Proc Natl Acad Sci U S A. 2006 Aug 8; 103(32):11904-9.
    View in: PubMed
  66. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10; 442(7103):700-4.
    View in: PubMed
  67. Frueh DP, Sun ZY, Vosburg DA, Walsh CT, Hoch JC, Wagner G. Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Am Chem Soc. 2006 May 3; 128(17):5757-63.
    View in: PubMed
  68. Park S, Takeuchi K, Wagner G. Solution structure of the first SRC homology 3 domain of human Nck2. J Biomol NMR. 2006 Mar; 34(3):203-8.
    View in: PubMed
  69. Reibarkh M, Malia TJ, Wagner G. NMR distinction of single- and multiple-mode binding of small-molecule protein ligands. J Am Chem Soc. 2006 Feb 22; 128(7):2160-1.
    View in: PubMed
  70. Takeuchi K, Wagner G. NMR studies of protein interactions. Curr Opin Struct Biol. 2006 Feb; 16(1):109-17.
    View in: PubMed
  71. Frueh DP, Vosburg DA, Walsh CT, Wagner G. Determination of all nOes in 1H-13C-Me-ILV-U-2H-15N proteins with two time-shared experiments. J Biomol NMR. 2006 Jan; 34(1):31-40.
    View in: PubMed
  72. Frueh DP, Arthanari H, Wagner G. Unambiguous assignment of NMR protein backbone signals with a time-shared triple-resonance experiment. J Biomol NMR. 2005 Nov; 33(3):187-96.
    View in: PubMed
  73. He C, Hus JC, Sun LJ, Zhou P, Norman DP, Dötsch V, Wei H, Gross JD, Lane WS, Wagner G, Verdine GL. A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. Mol Cell. 2005 Oct 7; 20(1):117-29.
    View in: PubMed
  74. Marintchev A, Wagner G. eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G. Biochemistry. 2005 Sep 20; 44(37):12265-72.
    View in: PubMed
  75. Oberer M, Marintchev A, Wagner G. Structural basis for the enhancement of eIF4A helicase activity by eIF4G. Genes Dev. 2005 Sep 15; 19(18):2212-23.
    View in: PubMed
  76. Sun ZY, Frueh DP, Selenko P, Hoch JC, Wagner G. Fast assignment of 15N-HSQC peaks using high-resolution 3D HNcocaNH experiments with non-uniform sampling. J Biomol NMR. 2005 Sep; 33(1):43-50.
    View in: PubMed
  77. Robinson MA, Park S, Sun ZY, Silver PA, Wagner G, Hogle JM. Multiple conformations in the ligand-binding site of the yeast nuclear pore-targeting domain of Nup116p. J Biol Chem. 2005 Oct 21; 280(42):35723-32.
    View in: PubMed
  78. Natarajan A, Guo Y, Arthanari H, Wagner G, Halperin JA, Chorev M. Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics. J Org Chem. 2005 Aug 5; 70(16):6362-8.
    View in: PubMed
  79. Park S, Isaacson R, Kim HT, Silver PA, Wagner G. Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites. Structure. 2005 Jul; 13(7):995-1005.
    View in: PubMed
  80. Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP. A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J Biol Chem. 2005 Aug 5; 280(31):28701-10.
    View in: PubMed
  81. Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman A. Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nat Struct Mol Biol. 2005 Jun; 12(6):526-32.
    View in: PubMed
  82. Sun ZY, Hyberts SG, Rovnyak D, Park S, Stern AS, Hoch JC, Wagner G. High-resolution aliphatic side-chain assignments in 3D HCcoNH experiments with joint H-C evolution and non-uniform sampling. J Biomol NMR. 2005 May; 32(1):55-60.
    View in: PubMed
  83. Frueh DP, Ito T, Li JS, Wagner G, Glaser SJ, Khaneja N. Sensitivity enhancement in NMR of macromolecules by application of optimal control theory. J Biomol NMR. 2005 May; 32(1):23-30.
    View in: PubMed
  84. Roehrl MH, Heffron GJ, Wagner G. Correspondence between spin-dynamic phases and pulse program phases of NMR spectrometers. J Magn Reson. 2005 Jun; 174(2):325-30.
    View in: PubMed
  85. Ivanov D, Stone JR, Maki JL, Collins T, Wagner G. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. Mol Cell. 2005 Jan 7; 17(1):137-43.
    View in: PubMed
  86. Roehrl MH, Wang JY, Wagner G. A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization. Biochemistry. 2004 Dec 28; 43(51):16056-66.
    View in: PubMed
  87. Roehrl MH, Wang JY, Wagner G. Discovery of small-molecule inhibitors of the NFAT--calcineurin interaction by competitive high-throughput fluorescence polarization screening. Biochemistry. 2004 Dec 28; 43(51):16067-75.
    View in: PubMed
  88. Walters KJ, Goh AM, Wang Q, Wagner G, Howley PM. Ubiquitin family proteins and their relationship to the proteasome: a structural perspective. Biochim Biophys Acta. 2004 Nov 29; 1695(1-3):73-87.
    View in: PubMed
  89. Sun ZY, Kim ST, Kim IC, Fahmy A, Reinherz EL, Wagner G. Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16867-72.
    View in: PubMed
  90. Chatwood LL, Müller J, Gross JD, Wagner G, Lippard SJ. NMR structure of the flavin domain from soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath). Biochemistry. 2004 Sep 28; 43(38):11983-91.
    View in: PubMed
  91. Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science. 2004 Sep 3; 305(5689):1466-70.
    View in: PubMed
  92. Ito T, Marintchev A, Wagner G. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. Structure. 2004 Sep; 12(9):1693-704.
    View in: PubMed
  93. Rovnyak D, Frueh DP, Sastry M, Sun ZY, Stern AS, Hoch JC, Wagner G. Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction. J Magn Reson. 2004 Sep; 170(1):15-21.
    View in: PubMed
  94. Marintchev A, Wagner G. Translation initiation: structures, mechanisms and evolution. Q Rev Biophys. 2004 Aug-Nov; 37(3-4):197-284.
    View in: PubMed
  95. Natarajan A, Moerke N, Fan YH, Chen H, Christ WJ, Wagner G, Halperin JA. Synthesis of fluorescein labeled 7-methylguanosinemonophosphate. Bioorg Med Chem Lett. 2004 May 17; 14(10):2657-60.
    View in: PubMed
  96. Kato M, Ito T, Wagner G, Ellenberger T. A molecular handoff between bacteriophage T7 DNA primase and T7 DNA polymerase initiates DNA synthesis. J Biol Chem. 2004 Jul 16; 279(29):30554-62.
    View in: PubMed
  97. Roehrl MH, Kang S, Aramburu J, Wagner G, Rao A, Hogan PG. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7554-9.
    View in: PubMed
  98. Ito T, Wagner G. Using codon optimization, chaperone co-expression, and rational mutagenesis for production and NMR assignments of human eIF2 alpha. J Biomol NMR. 2004 Apr; 28(4):357-67.
    View in: PubMed
  99. Misaghi S, Sun ZY, Stern P, Gaudet R, Wagner G, Ploegh H. Structural and functional analysis of human cytomegalovirus US3 protein. J Virol. 2004 Jan; 78(1):413-23.
    View in: PubMed
  100. Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JE, Wagner G. Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell. 2003 Dec 12; 115(6):739-50.
    View in: PubMed
  101. Lomakin IB, Kolupaeva VG, Marintchev A, Wagner G, Pestova TV. Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing. Genes Dev. 2003 Nov 15; 17(22):2786-97.
    View in: PubMed
  102. Bennett AE, Gross JD, Wagner G. Broadband 13C-13C adiabatic mixing in solution optimized for high fields. J Magn Reson. 2003 Nov; 165(1):59-79.
    View in: PubMed
  103. Freund C, Kühne R, Park S, Thiemke K, Reinherz EL, Wagner G. Structural investigations of a GYF domain covalently linked to a proline-rich peptide. J Biomol NMR. 2003 Oct; 27(2):143-9.
    View in: PubMed
  104. Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science. 2003 Sep 19; 301(5640):1725-8.
    View in: PubMed
  105. Roehrl MH, Hyberts SG, Jim Sun ZY, Fields AP, Wagner G. Letter to the Editor: Rapid backbone (1)H, (13)C, and (15)N assignment of the V1 domain of human PKC iota using the new program IBIS. J Biomol NMR. 2003 Aug; 26(4):373-4.
    View in: PubMed
  106. Roehrl MH, Hyberts SG, Sun ZY, Fields AP, Wagner G. Rapid backbone 1H, 13C, and 15N assignment of the V1 domain of human PKC iota using the new program IBIS. J Biomol NMR. 2003 Aug; 26(4):373-4.
    View in: PubMed
  107. Hyberts SG, Wagner G. IBIS--a tool for automated sequential assignment of protein spectra from triple resonance experiments. J Biomol NMR. 2003 Aug; 26(4):335-44.
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  108. Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11; 114(1):99-111.
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  109. Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G, Eck MJ. Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol. 2003 Jul; 10(7):504-12.
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  110. Kato M, Ito T, Wagner G, Richardson CC, Ellenberger T. Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis. Mol Cell. 2003 May; 11(5):1349-60.
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  111. Rovnyak D, Filip C, Itin B, Stern AS, Wagner G, Griffin RG, Hoch JC. Multiple-quantum magic-angle spinning spectroscopy using nonlinear sampling. J Magn Reson. 2003 Mar; 161(1):43-55.
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  112. Gross JD, Gelev VM, Wagner G. A sensitive and robust method for obtaining intermolecular NOEs between side chains in large protein complexes. J Biomol NMR. 2003 Mar; 25(3):235-42.
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  113. Marintchev A, Kolupaeva VG, Pestova TV, Wagner G. Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1535-40.
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  114. Freund C, Kühne R, Yang H, Park S, Reinherz EL, Wagner G. Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules. EMBO J. 2002 Nov 15; 21(22):5985-95.
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  115. Dormitzer PR, Sun ZY, Blixt O, Paulson JC, Wagner G, Harrison SC. Specificity and affinity of sialic acid binding by the rhesus rotavirus VP8* core. J Virol. 2002 Oct; 76(20):10512-7.
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  116. Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5367-72.
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  117. Dormitzer PR, Sun ZY, Wagner G, Harrison SC. The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. EMBO J. 2002 Mar 1; 21(5):885-97.
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  118. Fahmy A, Wagner G. TreeDock: a tool for protein docking based on minimizing van der Waals energies. J Am Chem Soc. 2002 Feb 20; 124(7):1241-50.
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  119. Lugovskoy AA, Degterev AI, Fahmy AF, Zhou P, Gross JD, Yuan J, Wagner G. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J Am Chem Soc. 2002 Feb 20; 124(7):1234-40.
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  120. Walters KJ, Kleijnen MF, Goh AM, Wagner G, Howley PM. Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. Biochemistry. 2002 Feb 12; 41(6):1767-77.
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  121. Müller J, Lugovskoy AA, Wagner G, Lippard SJ. NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase. Biochemistry. 2002 Jan 8; 41(1):42-51.
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