Kevin Joseph Staley, M.D.
|Title||Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Neurology, WAC 708
55 Fruit St
Boston MA 02114
Available: 07/10/12, Expires: 12/31/13
GABA is the principal inhibitory neurotransmitter in the mature brain, but GABA can excite neurons in the developing brain. Most seizure medications enhance the effects of GABA, and thus work poorly for seizures in the youngest infants. We have developed therapies that can alter the polarity GABA signaling, but how well these agents cross the blood brain barrier is still not well defined. Students will participate in therapeutic experiments involving multiphoton in vivo microscopy in transgenic animals expressing fluorophores that read out the polarity of GABA signaling.
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