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Last Name
Institution

Elliott D. Kieff, PH.D., M.D.

TitleHarriet Ryan Albee Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressChanning Laboratory
8th FL, Medicine/Micro and Mol Genetics
181 Longwood Ave
Boston MA 02115
Phone617/525-4252
Fax617/525-4257
Other Positions
TitleProfessor of Microbiology and Immunobiology
InstitutionBrigham and Women's Hospital
DepartmentMicrobiology and Immunobiology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Liu CD, Cheng CP, Fang JS, Chen LC, Zhao B, Kieff E, Peng CW. Modulation of Epstein-Barr Virus Nuclear Antigen 2-dependent transcription by protein arginine methyltransferase 5. Biochem Biophys Res Commun. 2013 Jan 18; 430(3):1097-102.
    View in: PubMed
  2. Liu CD, Chen YL, Min YL, Zhao B, Cheng CP, Kang MS, Chiu SJ, Kieff E, Peng CW. The nuclear chaperone nucleophosmin escorts an epstein-barr virus nuclear antigen to establish transcriptional cascades for latent infection in human B cells. PLoS Pathog. 2012 Dec; 8(12):e1003084.
    View in: PubMed
  3. Kim SY, Song KA, Kieff E, Kang MS. Small molecule and peptide-mediated inhibition of Epstein-Barr virus nuclear antigen 1 dimerization. Biochem Biophys Res Commun. 2012 Jul 27; 424(2):251-6.
    View in: PubMed
  4. Gewurz BE, Towfic F, Mar JC, Shinners NP, Takasaki K, Zhao B, Cahir-McFarland ED, Quackenbush J, Xavier RJ, Kieff E. Genome-wide siRNA screen for mediators of NF-?B activation. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2467-72.
    View in: PubMed
  5. Geiser V, Cahir-McFarland E, Kieff E. Latent membrane protein 1 is dispensable for Epstein-Barr virus replication in human embryonic kidney 293 cells. PLoS One. 2011; 6(8):e22929.
    View in: PubMed
  6. Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff E. Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36):14902-7.
    View in: PubMed
  7. Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36):14908-13.
    View in: PubMed
  8. Xing L, Kieff E. cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression. J Virol. 2011 Sep; 85(17):8929-39.
    View in: PubMed
  9. Gewurz BE, Mar JC, Padi M, Zhao B, Shinners NP, Takasaki K, Bedoya E, Zou JY, Cahir-McFarland E, Quackenbush J, Kieff E. Canonical NF-kappaB activation is essential for Epstein-Barr virus latent membrane protein 1 TES2/CTAR2 gene regulation. J Virol. 2011 Jul; 85(13):6764-73.
    View in: PubMed
  10. Verweij FJ, van Eijndhoven MA, Hopmans ES, Vendrig T, Wurdinger T, Cahir-McFarland E, Kieff E, Geerts D, van der Kant R, Neefjes J, Middeldorp JM, Pegtel DM. LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-?B activation. EMBO J. 2011 Jun 1; 30(11):2115-29.
    View in: PubMed
  11. Portal D, Zhao B, Calderwood MA, Sommermann T, Johannsen E, Kieff E. EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7808-13.
    View in: PubMed
  12. Calderwood MA, Lee S, Holthaus AM, Blacklow SC, Kieff E, Johannsen E. Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth. Virology. 2011 May 25; 414(1):19-25.
    View in: PubMed
  13. Maruo S, Zhao B, Johannsen E, Kieff E, Zou J, Takada K. Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4A and p14ARF expression. Proc Natl Acad Sci U S A. 2011 Feb 1; 108(5):1919-24.
    View in: PubMed
  14. Kang MS, Lee EK, Soni V, Lewis TA, Koehler AN, Srinivasan V, Kieff E. Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. J Virol. 2011 Mar; 85(6):2859-68.
    View in: PubMed
  15. Zhao B, Mar JC, Maruo S, Lee S, Gewurz BE, Johannsen E, Holton K, Rubio R, Takada K, Quackenbush J, Kieff E. Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines. Proc Natl Acad Sci U S A. 2011 Jan 4; 108(1):337-42.
    View in: PubMed
  16. Boehm D, Gewurz BE, Kieff E, Cahir-McFarland E. Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18103-8.
    View in: PubMed
  17. Lee S, Sakakibara S, Maruo S, Zhao B, Calderwood MA, Holthaus AM, Lai CY, Takada K, Kieff E, Johannsen E. Epstein-Barr virus nuclear protein 3C domains necessary for lymphoblastoid cell growth: interaction with RBP-Jkappa regulates TCL1. J Virol. 2009 Dec; 83(23):12368-77.
    View in: PubMed
  18. Maruo S, Wu Y, Ito T, Kanda T, Kieff ED, Takada K. Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4419-24.
    View in: PubMed
  19. Fernandez AF, Rosales C, Lopez-Nieva P, Graña O, Ballestar E, Ropero S, Espada J, Melo SA, Lujambio A, Fraga MF, Pino I, Javierre B, Carmona FJ, Acquadro F, Steenbergen RD, Snijders PJ, Meijer CJ, Pineau P, Dejean A, Lloveras B, Capella G, Quer J, Buti M, Esteban JI, Allende H, Rodriguez-Frias F, Castellsague X, Minarovits J, Ponce J, Capello D, Gaidano G, Cigudosa JC, Gomez-Lopez G, Pisano DG, Valencia A, Piris MA, Bosch FX, Cahir-McFarland E, Kieff E, Esteller M. The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res. 2009 Mar; 19(3):438-51.
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  20. Choy E, Yelensky R, Bonakdar S, Plenge RM, Saxena R, De Jager PL, Shaw SY, Wolfish CS, Slavik JM, Cotsapas C, Rivas M, Dermitzakis ET, Cahir-McFarland E, Kieff E, Hafler D, Daly MJ, Altshuler D. Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet. 2008 Nov; 4(11):e1000287.
    View in: PubMed
  21. Song YJ, Izumi KM, Shinners NP, Gewurz BE, Kieff E. IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18448-53.
    View in: PubMed
  22. Kang MS, Soni V, Bronson R, Kieff E. Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice. J Virol. 2008 Apr; 82(8):4180-3.
    View in: PubMed
  23. Xing L, Kieff E. Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication. J Virol. 2007 Sep; 81(18):9967-75.
    View in: PubMed
  24. Calderwood MA, Venkatesan K, Xing L, Chase MR, Vazquez A, Holthaus AM, Ewence AE, Li N, Hirozane-Kishikawa T, Hill DE, Vidal M, Kieff E, Johannsen E. Epstein-Barr virus and virus human protein interaction maps. Proc Natl Acad Sci U S A. 2007 May 1; 104(18):7606-11.
    View in: PubMed
  25. Peng CW, Zhao B, Chen HC, Chou ML, Lai CY, Lin SZ, Hsu HY, Kieff E. Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2. Blood. 2007 Jun 15; 109(12):5447-54.
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  26. Soni V, Cahir-McFarland E, Kieff E. LMP1 TRAFficking activates growth and survival pathways. Adv Exp Med Biol. 2007; 597:173-87.
    View in: PubMed
  27. Portal D, Rosendorff A, Kieff E. Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19278-83.
    View in: PubMed
  28. Chen A, Zhao B, Kieff E, Aster JC, Wang F. EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines. J Virol. 2006 Oct; 80(20):10139-50.
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  29. Soni V, Yasui T, Cahir-McFarland E, Kieff E. LMP1 transmembrane domain 1 and 2 (TM1-2) FWLY mediates intermolecular interactions with TM3-6 to activate NF-kappaB. J Virol. 2006 Nov; 80(21):10787-93.
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  30. Hatzivassiliou EG, Kieff E, Mosialos G. Constitutive CD40 signaling phenocopies the transforming function of the Epstein-Barr virus oncoprotein LMP1 in vitro. Leuk Res. 2007 Mar; 31(3):315-20.
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  31. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D, Brenner D, Collins F, Elias J, Greene W, Horowitz R, Jameson L, Kieff E, Thompson C, Swain JL. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. J Clin Invest. 2006 Aug; 116(8):2058-9.
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  32. Rosendorff A, Sakakibara S, Lu S, Kieff E, Xuan Y, DiBacco A, Shi Y, Shi Y, Gill G. NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A. 2006 Apr 4; 103(14):5308-13.
    View in: PubMed
  33. Yuan J, Cahir-McFarland E, Zhao B, Kieff E. Virus and cell RNAs expressed during Epstein-Barr virus replication. J Virol. 2006 Mar; 80(5):2548-65.
    View in: PubMed
  34. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2689-94.
    View in: PubMed
  35. Zhao B, Maruo S, Cooper A, R Chase M, Johannsen E, Kieff E, Cahir-McFarland E. RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines. Proc Natl Acad Sci U S A. 2006 Feb 7; 103(6):1900-5.
    View in: PubMed
  36. Ling PD, Peng RS, Nakajima A, Yu JH, Tan J, Moses SM, Yang WH, Zhao B, Kieff E, Bloch KD, Bloch DB. Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J. 2005 Oct 19; 24(20):3565-75.
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  37. Maruo S, Johannsen E, Illanes D, Cooper A, Zhao B, Kieff E. Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical. J Virol. 2005 Aug; 79(16):10171-9.
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  38. Tzimas C, Michailidou G, Arsenakis M, Kieff E, Mosialos G, Hatzivassiliou EG. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. Cell Signal. 2006 Jan; 18(1):83-92.
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  39. Rainio EM, Ahlfors H, Carter KL, Ruuska M, Matikainen S, Kieff E, Koskinen PJ. Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity. Virology. 2005 Mar 15; 333(2):201-6.
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  40. Kang MS, Lu H, Yasui T, Sharpe A, Warren H, Cahir-McFarland E, Bronson R, Hung SC, Kieff E. Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):820-5.
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  41. Lee S, Andrieu C, Saltel F, Destaing O, Auclair J, Pouchkine V, Michelon J, Salaun B, Kobayashi R, Jurdic P, Kieff ED, Sylla BS. IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation. Proc Natl Acad Sci U S A. 2004 Dec 14; 101(50):17416-21.
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  42. Johannsen E, Luftig M, Chase MR, Weicksel S, Cahir-McFarland E, Illanes D, Sarracino D, Kieff E. Proteins of purified Epstein-Barr virus. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16286-91.
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  43. Peng CW, Zhao B, Kieff E. Four EBNA2 domains are important for EBNALP coactivation. J Virol. 2004 Oct; 78(20):11439-42.
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  44. Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM, Kieff E. Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol. 2004 Apr; 78(8):4108-19.
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  45. Peng CW, Xue Y, Zhao B, Johannsen E, Kieff E, Harada S. Direct interactions between Epstein-Barr virus leader protein LP and the EBNA2 acidic domain underlie coordinate transcriptional regulation. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1033-8.
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  46. Rosendorff A, Illanes D, David G, Lin J, Kieff E, Johannsen E. EBNA3C coactivation with EBNA2 requires a SUMO homology domain. J Virol. 2004 Jan; 78(1):367-77.
    View in: PubMed
  47. Yasui T, Luftig M, Soni V, Kieff E. Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling. Proc Natl Acad Sci U S A. 2004 Jan 6; 101(1):278-83.
    View in: PubMed
  48. Luftig M, Yasui T, Soni V, Kang MS, Jacobson N, Cahir-McFarland E, Seed B, Kieff E. Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. Proc Natl Acad Sci U S A. 2004 Jan 6; 101(1):141-6.
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  49. Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E. Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15595-600.
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  50. Maruo S, Johannsen E, Illanes D, Cooper A, Kieff E. Epstein-Barr Virus nuclear protein EBNA3A is critical for maintaining lymphoblastoid cell line growth. J Virol. 2003 Oct; 77(19):10437-47.
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  51. Cooper A, Johannsen E, Maruo S, Cahir-McFarland E, Illanes D, Davidson D, Kieff E. EBNA3A association with RBP-Jkappa down-regulates c-myc and Epstein-Barr virus-transformed lymphoblast growth. J Virol. 2003 Jan; 77(2):999-1010.
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  52. Carter KL, Cahir-McFarland E, Kieff E. Epstein-barr virus-induced changes in B-lymphocyte gene expression. J Virol. 2002 Oct; 76(20):10427-36.
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  53. Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. 2002 Sep 16; 21(18):4950-8.
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  54. Han I, Xue Y, Harada S, Orstavik S, Skalhegg B, Kieff E. Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins. Mol Cell Biol. 2002 Apr; 22(7):2136-46.
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  55. Cahir-McFarland E, Kieff E. NF-kappaB inhibition in EBV-transformed lymphoblastoid cell lines. Recent Results Cancer Res. 2002; 159:44-8.
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  56. Higuchi M, Kieff E, Izumi KM. The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines. J Virol. 2002 Jan; 76(1):455-9.
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  57. Lin J, Johannsen E, Robertson E, Kieff E. Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2. J Virol. 2002 Jan; 76(1):232-42.
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  58. Kang MS, Hung SC, Kieff E. Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15233-8.
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  59. Higuchi M, Izumi KM, Kieff E. Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4675-80.
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  60. Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E. Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40. J Biol Chem. 2001 May 4; 276(18):14602-6.
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  61. Han I, Harada S, Weaver D, Xue Y, Lane W, Orstavik S, Skalhegg B, Kieff E. EBNA-LP associates with cellular proteins including DNA-PK and HA95. J Virol. 2001 Mar; 75(5):2475-81.
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  62. Harada S, Yalamanchili R, Kieff E. Epstein-Barr virus nuclear protein 2 has at least two N-terminal domains that mediate self-association. J Virol. 2001 Mar; 75(5):2482-7.
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  63. Hung SC, Kang MS, Kieff E. Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1865-70.
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  64. Baron S, Poast J, Rizzo D, McFarland E, Kieff E. Electroporation of antibodies, DNA, and other macromolecules into cells: a highly efficient method. J Immunol Methods. 2000 Aug 28; 242(1-2):115-26.
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  65. Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E. The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7470-5.
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  66. Cahir-McFarland ED, Davidson DM, Schauer SL, Duong J, Kieff E. NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):6055-60.
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  67. Wang L, Grossman SR, Kieff E. Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter. Proc Natl Acad Sci U S A. 2000 Jan 4; 97(1):430-5.
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  68. Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS. Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95. Biol Cell. 2000 Jan; 92(1):27-37.
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  69. Callahan J, Aster J, Sklar J, Kieff E, Robertson ES. Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells. Leukemia. 2000 Jan; 14(1):84-92.
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  70. Kaye KM, Izumi KM, Li H, Johannsen E, Davidson D, Longnecker R, Kieff E. An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation. J Virol. 1999 Dec; 73(12):10525-30.
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  71. Izumi KM, Cahir McFarland ED, Riley EA, Rizzo D, Chen Y, Kieff E. The residues between the two transformation effector sites of Epstein-Barr virus latent membrane protein 1 are not critical for B-lymphocyte growth transformation. J Virol. 1999 Dec; 73(12):9908-16.
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  72. Paya CV, Fung JJ, Nalesnik MA, Kieff E, Green M, Gores G, Habermann TM, Wiesner PH, Swinnen JL, Woodle ES, Bromberg JS. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and The Mayo Clinic Organized International Consensus Development Meeting. Transplantation. 1999 Nov 27; 68(10):1517-25.
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  73. Goldmacher VS, Bartle LM, Skaletskaya A, Dionne CA, Kedersha NL, Vater CA, Han JW, Lutz RJ, Watanabe S, Cahir McFarland ED, Kieff ED, Mocarski ES, Chittenden T. A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12536-41.
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  74. Ye H, Park YC, Kreishman M, Kieff E, Wu H. The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol Cell. 1999 Sep; 4(3):321-30.
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  75. Izumi KM, Cahir McFarland ED, Ting AT, Riley EA, Seed B, Kieff ED. The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. Mol Cell Biol. 1999 Aug; 19(8):5759-67.
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  76. Lee H, Choi JK, Li M, Kaye K, Kieff E, Jung JU. Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP. J Virol. 1999 May; 73(5):3913-9.
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  77. Kube D, Vockerodt M, Weber O, Hell K, Wolf J, Haier B, Grässer FA, Müller-Lantzsch N, Kieff E, Diehl V, Tesch H. Expression of epstein-barr virus nuclear antigen 1 is associated with enhanced expression of CD25 in the Hodgkin cell line L428. J Virol. 1999 Feb; 73(2):1630-6.
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  78. Harada S, Yalamanchili R, Kieff E. Residues 231 to 280 of the Epstein-Barr virus nuclear protein 2 are not essential for primary B-lymphocyte growth transformation. J Virol. 1998 Dec; 72(12):9948-54.
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  79. Devergne O, Cahir McFarland ED, Mosialos G, Izumi KM, Ware CF, Kieff E. Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression. J Virol. 1998 Oct; 72(10):7900-8.
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  80. Sadelain M, Kieff E. Why commonplace encounters turn to fatal attraction. Nat Genet. 1998 Oct; 20(2):103-4.
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  81. Sylla BS, Hung SC, Davidson DM, Hatzivassiliou E, Malinin NL, Wallach D, Gilmore TD, Kieff E, Mosialos G. Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10106-11.
    View in: PubMed
  82. Hatzivassiliou E, Miller WE, Raab-Traub N, Kieff E, Mosialos G. A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-kappa B, and stress-activated protein kinase. J Immunol. 1998 Feb 1; 160(3):1116-21.
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  83. Kieff E. Current perspectives on the molecular pathogenesis of virus-induced cancers in human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst Monogr. 1998; (23):7-14.
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  84. Izumi KM, Kieff ED. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12592-7.
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  85. Kieff E. Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12732.
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  86. Devergne O, Birkenbach M, Kieff E. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):12041-6.
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  87. Harada S, Kieff E. Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation. J Virol. 1997 Sep; 71(9):6611-8.
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  88. Chatila T, Ho N, Liu P, Liu S, Mosialos G, Kieff E, Speck SH. The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication. J Virol. 1997 Sep; 71(9):6560-7.
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  89. Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J Biol Chem. 1997 Apr 25; 272(17):11336-43.
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  90. VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF. Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2460-5.
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  91. Izumi KM, Kaye KM, Kieff ED. The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1447-52.
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  197. Pearson GR, Luka J, Petti L, Sample J, Birkenbach M, Braun D, Kieff E. Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex. Virology. 1987 Sep; 160(1):151-61.
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  198. Reiss CS, Wang D, Ghosh D, Gaposchkin C, Kieff E. Recognition of EBV plasma membrane protein expressed on murine cells after gene transfer. J Immunol. 1987 Aug 1; 139(3):711-4.
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  199. Tanner J, Weis J, Fearon D, Whang Y, Kieff E. Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis. Cell. 1987 Jul 17; 50(2):203-13.
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  200. Liebowitz D, Kopan R, Fuchs E, Sample J, Kieff E. An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes. Mol Cell Biol. 1987 Jul; 7(7):2299-308.
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  201. Whang Y, Silberklang M, Morgan A, Munshi S, Lenny AB, Ellis RW, Kieff E. Expression of the Epstein-Barr virus gp350/220 gene in rodent and primate cells. J Virol. 1987 Jun; 61(6):1796-807.
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  202. Rowe M, Evans HS, Young LS, Hennessy K, Kieff E, Rickinson AB. Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells. J Gen Virol. 1987 Jun; 68 ( Pt 6):1575-86.
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  203. Lowe RS, Keller PM, Keech BJ, Davison AJ, Whang Y, Morgan AJ, Kieff E, Ellis RW. Varicella-zoster virus as a live vector for the expression of foreign genes. Proc Natl Acad Sci U S A. 1987 Jun; 84(11):3896-900.
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  204. Wang F, Gregory CD, Rowe M, Rickinson AB, Wang D, Birkenbach M, Kikutani H, Kishimoto T, Kieff E. Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23. Proc Natl Acad Sci U S A. 1987 May; 84(10):3452-6.
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  205. Wang F, Petti L, Braun D, Seung S, Kieff E. A bicistronic Epstein-Barr virus mRNA encodes two nuclear proteins in latently infected, growth-transformed lymphocytes. J Virol. 1987 Apr; 61(4):945-54.
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  206. Gong M, Ooka T, Matsuo T, Kieff E. Epstein-Barr virus glycoprotein homologous to herpes simplex virus gB. J Virol. 1987 Feb; 61(2):499-508.
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  207. Schultz LD, Tanner J, Hofmann KJ, Emini EA, Condra JH, Jones RE, Kieff E, Ellis RW. Expression and secretion in yeast of a 400-kDa envelope glycoprotein derived from Epstein-Barr virus. Gene. 1987; 54(1):113-23.
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  208. Szigeti R, Timar L, Weiland O, Henle W, Henle G, Hennessy K, Kieff E, Sulitzeanu D, Dillner J, Klein G. Epstein-Barr virus (EBV) antigen-specific leukocyte migration inhibition (LMI) in infectious mononucleosis (IM). I. Kinetics and response to a membrane protein on EBV-transformed cells. Clin Immunol Immunopathol. 1986 Dec; 41(3):342-50.
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  209. Dambaugh T, Wang F, Hennessy K, Woodland E, Rickinson A, Kieff E. Expression of the Epstein-Barr virus nuclear protein 2 in rodent cells. J Virol. 1986 Aug; 59(2):453-62.
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  210. Hennessy K, Wang F, Bushman EW, Kieff E. Definitive identification of a member of the Epstein-Barr virus nuclear protein 3 family. Proc Natl Acad Sci U S A. 1986 Aug; 83(15):5693-7.
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  211. Sample J, Hummel M, Braun D, Birkenbach M, Kieff E. Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5096-100.
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  212. Liebowitz D, Wang D, Kieff E. Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virus. J Virol. 1986 Apr; 58(1):233-7.
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  213. Sulitzeanu D, Szigeti R, Klein G, Hennessy K, Kieff E. Leukocyte migration inhibition demonstrates a human T-cell response to a membrane protein expressed in latent Epstein-Barr virus infection. J Virol. 1986 Apr; 58(1):230-2.
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  214. Hummel M, Arsenakis M, Marchini A, Lee L, Roizman B, Kieff E. Herpes simplex virus expressing Epstein-Barr virus nuclear antigen 1. Virology. 1986 Jan 30; 148(2):337-48.
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  215. Wang D, Liebowitz D, Kieff E. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell. 1985 Dec; 43(3 Pt 2):831-40.
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  216. Hennessy K, Fennewald S, Kieff E. A third viral nuclear protein in lymphoblasts immortalized by Epstein-Barr virus. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5944-8.
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  217. Beisel C, Tanner J, Matsuo T, Thorley-Lawson D, Kezdy F, Kieff E. Two major outer envelope glycoproteins of Epstein-Barr virus are encoded by the same gene. J Virol. 1985 Jun; 54(3):665-74.
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  218. Hennessy K, Kieff E. A second nuclear protein is encoded by Epstein-Barr virus in latent infection. Science. 1985 Mar 8; 227(4691):1238-40.
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  219. Heller M, Flemington E, Kieff E, Deininger P. Repeat arrays in cellular DNA related to the Epstein-Barr virus IR3 repeat. Mol Cell Biol. 1985 Mar; 5(3):457-65.
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  220. Kieff E, Hennessy K, Fennewald S, Matsuo T, Dambaugh T, Heller M, Hummel M. Biochemistry of latent Epstein-Barr virus infection and associated cell growth transformation. IARC Sci Publ. 1985; (60):323-39.
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  221. Matsuo T, Heller M, Petti L, O'Shiro E, Kieff E. Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA. Science. 1984 Dec 14; 226(4680):1322-5.
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  222. Dambaugh T, Hennessy K, Chamnankit L, Kieff E. U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2. Proc Natl Acad Sci U S A. 1984 Dec; 81(23):7632-6.
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  223. Luka J, Kreofsky T, Pearson GR, Hennessy K, Kieff E. Identification and characterization of a cellular protein that cross-reacts with the Epstein-Barr virus nuclear antigen. J Virol. 1984 Dec; 52(3):833-8.
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  224. Hennessy K, Fennewald S, Hummel M, Cole T, Kieff E. A membrane protein encoded by Epstein-Barr virus in latent growth-transforming infection. Proc Natl Acad Sci U S A. 1984 Nov; 81(22):7207-11.
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  225. Volsky DJ, Gross T, Sinangil F, Kuszynski C, Bartzatt R, Dambaugh T, Kieff E. Expression of Epstein-Barr virus (EBV) DNA and cloned DNA fragments in human lymphocytes following Sendai virus envelope-mediated gene transfer. Proc Natl Acad Sci U S A. 1984 Oct; 81(19):5926-30.
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  226. Fennewald S, van Santen V, Kieff E. Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein. J Virol. 1984 Aug; 51(2):411-9.
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  227. Hummel M, Thorley-Lawson D, Kieff E. An Epstein-Barr virus DNA fragment encodes messages for the two major envelope glycoproteins (gp350/300 and gp220/200). J Virol. 1984 Feb; 49(2):413-7.
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  228. Hennessy K, Kieff E. One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine copolymer domain. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5665-9.
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  229. Pearson GR, Vroman B, Chase B, Sculley T, Hummel M, Kieff E. Identification of polypeptide components of the Epstein-Barr virus early antigen complex with monoclonal antibodies. J Virol. 1983 Jul; 47(1):193-201.
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  230. Hennessy K, Heller M, van Santen V, Kieff E. Simple repeat array in Epstein-Barr virus DNA encodes part of the Epstein-Barr nuclear antigen. Science. 1983 Jun 24; 220(4604):1396-8.
    View in: PubMed
  231. van Santen V, Cheung A, Hummel M, Kieff E. RNA encoded by the IR1-U2 region of Epstein-Barr virus DNA in latently infected, growth-transformed cells. J Virol. 1983 May; 46(2):424-33.
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  232. Henderson A, Ripley S, Heller M, Kieff E. Chromosome site for Epstein-Barr virus DNA in a Burkitt tumor cell line and in lymphocytes growth-transformed in vitro. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):1987-91.
    View in: PubMed
  233. Dambaugh TR, Kieff E. Identification and nucleotide sequences of two similar tandem direct repeats in Epstein-Barr virus DNA. J Virol. 1982 Dec; 44(3):823-33.
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  234. Heller M, van Santen V, Kieff E. Simple repeat sequence in Epstein-Barr virus DNA is transcribed in latent and productive infections. J Virol. 1982 Oct; 44(1):311-20.
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  235. Heller M, Henderson A, Kieff E. Repeat array in Epstein-Barr virus DNA is related to cell DNA sequences interspersed on human chromosomes. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):5916-20.
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  236. Kieff E, Dambaugh T, Heller M, King W, Cheung A, van Santen V, Hummel M, Beisel C, Fennewald S, Hennessy K, Heineman T. The biology and chemistry of Epstein-Barr virus. J Infect Dis. 1982 Oct; 146(4):506-17.
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  237. Cheung A, Kieff E. Long internal direct repeat in Epstein-Barr virus DNA. J Virol. 1982 Oct; 44(1):286-94.
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  238. Hummel M, Kieff E. Mapping of polypeptides encoded by the Epstein-Barr virus genome in productive infection. Proc Natl Acad Sci U S A. 1982 Sep; 79(18):5698-702.
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  239. King W, Dambaugh T, Heller M, Dowling J, Kieff E. Epstein-Barr virus DNA XII. A variable region of the Epstein-Barr virus genome is included in the P3HR-1 deletion. J Virol. 1982 Sep; 43(3):979-86.
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  240. Hummel M, Kieff E. Epstein-Barr virus RNA. VIII. Viral RNA in permissively infected B95-8 cells. J Virol. 1982 Jul; 43(1):262-72.
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  241. Heller M, Gerber P, Kieff E. DNA of herpesvirus pan, a third member of the Epstein-Barr virus-Herpesvirus papio group. J Virol. 1982 Mar; 41(3):931-9.
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  242. Cheung A, Kieff E. Epstein-Barr virus DNA. X. Direct repeat within the internal direct repeat of Epstein-Barr virus DNA. J Virol. 1981 Nov; 40(2):501-7.
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  243. Slovin SF, Glassy MC, Dambaugh T, Catalano MA, Curry RA, Ferrone S, Kieff E, Vaughan JH, Carson DA. Discordant expression of 2 Epstein-Barr virus-associated antigens, EBNA and RANA, in man-rodent somatic cell hybrids. J Immunol. 1981 Aug; 127(2):585-90.
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  244. Heller M, Dambaugh T, Kieff E. Epstein-Barr virus DNA. IX. Variation among viral DNAs from producer and nonproducer infected cells. J Virol. 1981 May; 38(2):632-48.
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  245. King W, Van Santen V, Kieff E. Epstein-Barr virus RNA. VI. Viral RNA in restringently and abortively infected Raji cells. J Virol. 1981 May; 38(2):649-60.
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  246. van Santen V, Cheung A, Kieff E. Epstein-Barr virus RNA VII: size and direction of transcription of virus-specified cytoplasmic RNAs in a transformed cell line. Proc Natl Acad Sci U S A. 1981 Mar; 78(3):1930-4.
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  247. Heller M, Kieff E. Colinearity between the DNAs of Epstein-Barr virus and herpesvirus papio. J Virol. 1981 Feb; 37(2):821-6.
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  248. Heller M, Gerber P, Kieff E. Herpesvirus papio DNA is similar in organization to Epstein-Barr virus DNA. J Virol. 1981 Feb; 37(2):698-709.
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  249. King W, Thomas-Powell AL, Raab-Traub N, Hawke M, Kieff E. Epstein-Barr virus RNA. V. Viral RNA in a restringently infected, growth-transformed cell line. J Virol. 1980 Nov; 36(2):506-18.
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  250. Raab-Traub N, Dambaugh T, Kieff E. DNA of Epstein-Barr virus VIII: B95-8, the previous prototype, is an unusual deletion derivative. Cell. 1980 Nov; 22(1 Pt 1):257-67.
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  251. Dambaugh T, Beisel C, Hummel M, King W, Fennewald S, Cheung A, Heller M, Raab-Traub N, Kieff E. Epstein-Barr virus (B95-8) DNA VII: molecular cloning and detailed mapping. Proc Natl Acad Sci U S A. 1980 May; 77(5):2999-3003.
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  252. Dambaugh T, Raab-Traub N, Heller M, Beisel C, Hummel M, Cheung A, Fennewald S, King W, Kieff E. Variations among isolates of Epstein-Barr virus. Ann N Y Acad Sci. 1980; 354:309-25.
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  253. Kieff E, Given D, Powell AL, King W, Dambaugh T, Raab-Traub N. Epstein-Barr virus: structure of the viral DNA and analysis of viral RNA in infected cells. Biochim Biophys Acta. 1979 Nov 30; 560(3):355-73.
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  254. Given D, Kieff E. DNA of Epstein-Barr virus. VI. Mapping of the internal tandem reiteration. J Virol. 1979 Aug; 31(2):315-24.
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  255. Given D, Yee D, Griem K, Kieff E. DNA of Epstein-Barr virus. V. Direct repeats of the ends of Epstein-Barr virus DNA. J Virol. 1979 Jun; 30(3):852-62.
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  256. Dambaugh T, Nkrumah FK, Biggar RJ, Kieff E. Epstein-Barr virus RNA in Burkitt tumor tissue. Cell. 1979 Feb; 16(2):313-22.
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  257. Powell AL, King W, Kieff E. Epstein-Barr virus-specific RNA. III. Mapping of DNA encoding viral RNA in restringent infection. J Virol. 1979 Jan; 29(1):261-74.
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  258. Given D, Kieff E. DNA of Epstein-Barr virus. IV. Linkage map of restriction enzyme fragments of the B95-8 and W91 strains of Epstein-Barr Virus. J Virol. 1978 Nov; 28(2):524-42.
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  259. Raab-Traub N, Pritchett R, Kieff E. DNA of Epstein-Barr virus. III. Identification of restriction enzyme fragments that contain DNA sequences which differ among strains of Epstein-Barr virus. J Virol. 1978 Aug; 27(2):388-98.
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  260. Kieff E, Raab-Traub N, Given D, King W, Powell AT, Pritchett R, Dambaugh T. Mapping of putative transforming sequences of EBV DNA. IARC Sci Publ. 1978; (24 Pt 1):527-52.
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  261. Hayward SD, Kieff E. DNA of Epstein-Barr virus. II. Comparison of the molecular weights of restriction endonuclease fragments of the DNA of Epstein-Barr virus strains and identification of end fragments of the B95-8 strain. J Virol. 1977 Aug; 23(2):421-9.
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  262. Orellana T, Kieff E. Epstein-barr virus-specific RNA. II. Analysis of polyadenylated viral RNA in restringent, abortive, and prooductive infections. J Virol. 1977 May; 22(2):321-30.
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  263. Pritchett R, Pedersen M, Kieff E. Complexity of EBV homologous DNA in continuous lymphoblastoid cell lines. Virology. 1976 Oct 1; 74(1):227-31.
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  264. Pritchett R, Pendersen M, Kieff E. Complexity of EBV homologous DNA in continous lymphoblastoid cell lines. Virology. 1976 Oct 1; 74(1):227-31.
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  265. Gerber P, Pritchett RF, Kieff ED. Antigens and DNA of a chimpanzee agent related to Epstein-Barr virus. J Virol. 1976 Sep; 19(3):1090-9.
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  266. Hayward SD, Kieff ED. Epstein-Barr virus-specific RNA. I. Analysis of viral RNA in cellular extracts and in the polyribosomal fraction of permissive and nonpermissive lymphoblastoid cell lines. J Virol. 1976 May; 18(2):518-25.
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  267. Dolyniuk M, Wolff E, Kieff E. Proteins of Epstein-Barr Virus. II. Electrophoretic analysis of the polypeptides of the nucleocapsid and the glucosamine- and polysaccharide-containing components of enveloped virus. J Virol. 1976 Apr; 18(1):289-97.
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  268. Dolyniuk M, Pritchett R, Kieff E. Proteins of Epstein-Barr virus. I. Analysis of the polypeptides of purified enveloped Epstein-Barr virus. J Virol. 1976 Mar; 17(3):935-49.
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  269. Gerber P, Nkrumah FK, Pritchett R, Kieff E. Comparative studies of Epstein-Barr virus strains from Ghana and the United States. Int J Cancer. 1976 Jan 15; 17(1):71-81.
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  270. Olson RE, Morello JA, Kieff ED. Antibiotic treatment of oral anaerobic infections. J Oral Surg. 1975 Aug; 33(8):619-21.
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  271. Pritchett RF, Hayward SD, Kieff ED. DNA of Epstein-Barr virus. I. Comparative studies of the DNA of Epstein-Barr virus from HR-1 and B95-8 cells: size, structure, and relatedness. J Virol. 1975 Mar; 15(3):556-9.
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  272. Pritchett RP, Hayward SD, Kieff ED. Analysis of the DNA OF Epstein-Barr viruses and transcriptional products in transformed cells. IARC Sci Publ. 1975; (11 Pt 1):177-89.
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  273. Finley R, Kieff E, Thomsen S, Fennessy J, Beem M, Lerner S, Morello J. Bronchial brushing in the diagnosis of pulmonary disease in patients at risk for opportunistic infection. Am Rev Respir Dis. 1974 Mar; 109(3):379-87.
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  274. Kieff E, Levine J. Homology between Burkitt herpes viral DNA and DNA in continuous lymphoblastoid cells from patients with infectious mononucleosis. Proc Natl Acad Sci U S A. 1974 Feb; 71(2):355-8.
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  275. Kieff E, Hoyer B, Bachenheimer S, Roizman B. Genetic relatedness of type 1 and type 2 herpes simplex viruses. J Virol. 1972 May; 9(5):738-45.
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  276. Kieff ED, Bachenheimer SL, Roizman B. Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2. J Virol. 1971 Aug; 8(2):125-32.
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  277. Lee LF, Kieff ED, Bachenheimer SL, Roizman B, Spear PG, Burmester BR, Nazerian K. Size and composition of Marek's disease virus deoxyribonucleic acid. J Virol. 1971 Mar; 7(3):289-94.
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  278. Lee LF, Roizman B, Spear PG, Kieff ED, Burmester BR, Nazerian K. Marek's disease herpes virus: a cytomegalovirus. Proc Natl Acad Sci U S A. 1969 Nov; 64(3):952-6.
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  279. Kieff ED, McCarty DJ. Hypertrophic osteoarthropathy with arthritis and synovial calcification in a patient with alcoholic cirrhosis. Arthritis Rheum. 1969 Jun; 12(3):261-8.
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  280. Ejercito PM, Kieff ED, Roizman B. Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. J Gen Virol. 1968 May; 2(3):357-64.
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