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Bernardo Luis Sabatini, Ph.D., M.D.

TitleTakeda Professor of Neurobiology
InstitutionHarvard Medical School
DepartmentNeurobiology
AddressHarvard Medical School
Neurobiology
220 Longwood Ave
Boston MA 02115
Phone617/432-5670
Fax617/734-7557

 Research 
 research resources
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in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Bernardo Sabatini Lab - Mouse strains (2)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Murphy JA, Stein IS, Lau CG, Peixoto RT, Aman TK, Kaneko N, Aromolaran K, Saulnier JL, Popescu GK, Sabatini BL, Hell JW, Zukin RS. Phosphorylation of Ser1166 on GluN2B by PKA Is Critical to Synaptic NMDA Receptor Function and Ca2+ Signaling in Spines. J Neurosci. 2014 Jan 15; 34(3):869-79.
    View in: PubMed
  2. Olson JP, Banghart MR, Sabatini BL, Ellis-Davies GC. Spectral evolution of a photochemical protecting group for orthogonal two-color uncaging with visible light. J Am Chem Soc. 2013 Oct 23; 135(42):15948-54.
    View in: PubMed
  3. Bateup HS, Denefrio CL, Johnson CA, Saulnier JL, Sabatini BL. Temporal dynamics of a homeostatic pathway controlling neural network activity. Front Mol Neurosci. 2013; 6:28.
    View in: PubMed
  4. Banghart MR, Williams JT, Shah RC, Lavis LD, Sabatini BL. Caged naloxone reveals opioid signaling deactivation kinetics. Mol Pharmacol. 2013 Nov; 84(5):687-95.
    View in: PubMed
  5. Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell. 2013 Aug 15; 154(4):928-39.
    View in: PubMed
  6. Gross GG, Junge JA, Mora RJ, Kwon HB, Olson CA, Takahashi TT, Liman ER, Ellis-Davies GC, McGee AW, Sabatini BL, Roberts RW, Arnold DB. Recombinant probes for visualizing endogenous synaptic proteins in living neurons. Neuron. 2013 Jun 19; 78(6):971-85.
    View in: PubMed
  7. Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL. Excitatory/Inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron. 2013 May 8; 78(3):510-22.
    View in: PubMed
  8. Olson JP, Kwon HB, Takasaki KT, Chiu CQ, Higley MJ, Sabatini BL, Ellis-Davies GC. Optically Selective Two-Photon Uncaging of Glutamate at 900 nm. J Am Chem Soc. 2013 Apr 24; 135(16):5954-7.
    View in: PubMed
  9. Takasaki KT, Ding JB, Sabatini BL. Live-Cell Superresolution Imaging by Pulsed STED Two-Photon Excitation Microscopy. Biophys J. 2013 Feb 19; 104(4):770-7.
    View in: PubMed
  10. Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits. 2013; 7:11.
    View in: PubMed
  11. Kwon HB, Kozorovitskiy Y, Oh WJ, Peixoto RT, Akhtar N, Saulnier JL, Gu C, Sabatini BL. Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat Neurosci. 2012 Nov; 15(12):1667-74.
    View in: PubMed
  12. Peixoto RT, Kunz PA, Kwon H, Mabb AM, Sabatini BL, Philpot BD, Ehlers MD. Transsynaptic signaling by activity-dependent cleavage of neuroligin-1. Neuron. 2012 Oct 18; 76(2):396-409.
    View in: PubMed
  13. Tritsch NX, Sabatini BL. Dopaminergic modulation of synaptic transmission in cortex and striatum. Neuron. 2012 Oct 4; 76(1):33-50.
    View in: PubMed
  14. Tritsch NX, Ding JB, Sabatini BL. Dopaminergic neurons inhibit striatal output through non-canonical release of GABA. Nature. 2012 Oct 11; 490(7419):262-6.
    View in: PubMed
  15. Carter BC, Giessel AJ, Sabatini BL, Bean BP. Transient sodium current at subthreshold voltages: activation by EPSP waveforms. Neuron. 2012 Sep 20; 75(6):1081-93.
    View in: PubMed
  16. Saunders A, Johnson CA, Sabatini BL. Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons. Front Neural Circuits. 2012; 6:47.
    View in: PubMed
  17. Kozorovitskiy Y, Saunders A, Johnson CA, Lowell BB, Sabatini BL. Recurrent network activity drives striatal synaptogenesis. Nature. 2012 May 31; 485(7400):646-50.
    View in: PubMed
  18. Sheng M, Sabatini BL, Südhof TC. Synapses and Alzheimer's disease. Cold Spring Harb Perspect Biol. 2012 May; 4(5).
    View in: PubMed
  19. Higley MJ, Sabatini BL. Calcium signaling in dendritic spines. Cold Spring Harb Perspect Biol. 2012 Apr; 4(4):a005686.
    View in: PubMed
  20. Chen Y, Sabatini BL. Signaling in dendritic spines and spine microdomains. Curr Opin Neurobiol. 2012 Jun; 22(3):389-96.
    View in: PubMed
  21. Liu T, Kong D, Shah BP, Ye C, Koda S, Saunders A, Ding JB, Yang Z, Sabatini BL, Lowell BB. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron. 2012 Feb 9; 73(3):511-22.
    View in: PubMed
  22. Banghart MR, Sabatini BL. Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue. Neuron. 2012 Jan 26; 73(2):249-59.
    View in: PubMed
  23. Ding JB, Oh WJ, Sabatini BL, Gu C. Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nat Neurosci. 2012 Feb; 15(2):215-23.
    View in: PubMed
  24. Sigrist SJ, Sabatini BL. Optical super-resolution microscopy in neurobiology. Curr Opin Neurobiol. 2012 Feb; 22(1):86-93.
    View in: PubMed
  25. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15414-9.
    View in: PubMed
  26. Bateup HS, Takasaki KT, Saulnier JL, Denefrio CL, Sabatini BL. Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. J Neurosci. 2011 Jun 15; 31(24):8862-9.
    View in: PubMed
  27. Giessel AJ, Sabatini BL. Boosting of synaptic potentials and spine Ca transients by the peptide toxin SNX-482 requires alpha-1E-encoded voltage-gated Ca channels. PLoS One. 2011; 6(6):e20939.
    View in: PubMed
  28. Kwon HB, Sabatini BL. Glutamate induces de novo growth of functional spines in developing cortex. Nature. 2011 Jun 2; 474(7349):100-4.
    View in: PubMed
  29. Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One. 2011; 6(4):e19155.
    View in: PubMed
  30. Goda Y, Sabatini BL. Synaptic function and regulation. Curr Opin Neurobiol. 2011 Apr; 21(2):205-7.
    View in: PubMed
  31. Giessel AJ, Sabatini BL. M1 muscarinic receptors boost synaptic potentials and calcium influx in dendritic spines by inhibiting postsynaptic SK channels. Neuron. 2010 Dec 9; 68(5):936-47.
    View in: PubMed
  32. Cheng J, Zhou X, Miller EL, Alvarez VA, Sabatini BL, Wong ST. Oriented Markov random field based dendritic spine segmentation for fluorescence microscopy images. Neuroinformatics. 2010 Oct; 8(3):157-70.
    View in: PubMed
  33. Higley MJ, Sabatini BL. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010 Aug; 13(8):958-66.
    View in: PubMed
  34. Bateup HS, Sabatini BL. For synapses, it's depression not death. Cell. 2010 May 28; 141(5):750-2.
    View in: PubMed
  35. Sturgill JF, Steiner P, Czervionke BL, Sabatini BL. Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. J Neurosci. 2009 Oct 14; 29(41):12845-54.
    View in: PubMed
  36. Bloodgood BL, Giessel AJ, Sabatini BL. Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines. PLoS Biol. 2009 Sep; 7(9):e1000190.
    View in: PubMed
  37. Ding JB, Takasaki KT, Sabatini BL. Supraresolution imaging in brain slices using stimulated-emission depletion two-photon laser scanning microscopy. Neuron. 2009 Aug 27; 63(4):429-37.
    View in: PubMed
  38. Higley MJ, Soler-Llavina GJ, Sabatini BL. Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration. Nat Neurosci. 2009 Sep; 12(9):1121-8.
    View in: PubMed
  39. Steiner P, Higley MJ, Xu W, Czervionke BL, Malenka RC, Sabatini BL. Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity. Neuron. 2008 Dec 10; 60(5):788-802.
    View in: PubMed
  40. Higley MJ, Sabatini BL. Calcium signaling in dendrites and spines: practical and functional considerations. Neuron. 2008 Sep 25; 59(6):902-13.
    View in: PubMed
  41. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42.
    View in: PubMed
  42. Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V. Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling. Cell Signal. 2008 Jun; 20(6):1084-91.
    View in: PubMed
  43. Xu W, Schlüter OM, Steiner P, Czervionke BL, Sabatini B, Malenka RC. Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron. 2008 Jan 24; 57(2):248-62.
    View in: PubMed
  44. Busetto G, Higley MJ, Sabatini BL. Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons. J Physiol. 2008 Mar 15; 586(6):1519-27.
    View in: PubMed
  45. Bloodgood BL, Sabatini BL. Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. J Physiol. 2008 Mar 15; 586(6):1475-80.
    View in: PubMed
  46. Sabatini BL. Neuroscience: neighbourly synapses. Nature. 2007 Dec 20; 450(7173):1173-5.
    View in: PubMed
  47. Carter AG, Soler-Llavina GJ, Sabatini BL. Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. J Neurosci. 2007 Aug 15; 27(33):8967-77.
    View in: PubMed
  48. Alvarez VA, Ridenour DA, Sabatini BL. Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. J Neurosci. 2007 Jul 11; 27(28):7365-76.
    View in: PubMed
  49. Cheng J, Zhou X, Miller E, Witt RM, Zhu J, Sabatini BL, Wong ST. A novel computational approach for automatic dendrite spines detection in two-photon laser scan microscopy. J Neurosci Methods. 2007 Sep 15; 165(1):122-34.
    View in: PubMed
  50. Bloodgood BL, Sabatini BL. Ca(2+) signaling in dendritic spines. Curr Opin Neurobiol. 2007 Jun; 17(3):345-51.
    View in: PubMed
  51. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14; 27(11):2866-75.
    View in: PubMed
  52. Zhang Y, Zhou X, Witt RM, Sabatini BL, Adjeroh D, Wong ST. Dendritic spine detection using curvilinear structure detector and LDA classifier. Neuroimage. 2007 Jun; 36(2):346-60.
    View in: PubMed
  53. Bloodgood BL, Sabatini BL. Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. Neuron. 2007 Jan 18; 53(2):249-60.
    View in: PubMed
  54. Alvarez VA, Sabatini BL. Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci. 2007; 30:79-97.
    View in: PubMed
  55. Alvarez VA, Ridenour DA, Sabatini BL. Retraction of synapses and dendritic spines induced by off-target effects of RNA interference. J Neurosci. 2006 Jul 26; 26(30):7820-5.
    View in: PubMed
  56. Soler-Llavina GJ, Sabatini BL. Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells. Nat Neurosci. 2006 Jun; 9(6):798-806.
    View in: PubMed
  57. Zhou X, Zhu J, Liu KY, Sabatini BL, Wong ST. Mutual information-based feature selection in studying perturbation of dendritic structure caused by TSC2 inactivation. Neuroinformatics. 2006; 4(1):81-94.
    View in: PubMed
  58. Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci. 2005 Dec; 8(12):1727-34.
    View in: PubMed
  59. Bloodgood BL, Sabatini BL. Neuronal activity regulates diffusion across the neck of dendritic spines. Science. 2005 Nov 4; 310(5749):866-9.
    View in: PubMed
  60. Ngo-Anh TJ, Bloodgood BL, Lin M, Sabatini BL, Maylie J, Adelman JP. SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines. Nat Neurosci. 2005 May; 8(5):642-9.
    View in: PubMed
  61. Carter AG, Sabatini BL. State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron. 2004 Oct 28; 44(3):483-93.
    View in: PubMed
  62. Yasuda R, Nimchinsky EA, Scheuss V, Pologruto TA, Oertner TG, Sabatini BL, Svoboda K. Imaging calcium concentration dynamics in small neuronal compartments. Sci STKE. 2004 Feb 10; 2004(219):pl5.
    View in: PubMed
  63. Yasuda R, Sabatini BL, Svoboda K. Plasticity of calcium channels in dendritic spines. Nat Neurosci. 2003 Sep; 6(9):948-55.
    View in: PubMed
  64. Pologruto TA, Sabatini BL, Svoboda K. ScanImage: flexible software for operating laser scanning microscopes. Biomed Eng Online. 2003 May 17; 2:13.
    View in: PubMed
  65. Oertner TG, Sabatini BL, Nimchinsky EA, Svoboda K. Facilitation at single synapses probed with optical quantal analysis. Nat Neurosci. 2002 Jul; 5(7):657-64.
    View in: PubMed
  66. Sabatini BL, Oertner TG, Svoboda K. The life cycle of Ca(2+) ions in dendritic spines. Neuron. 2002 Jan 31; 33(3):439-52.
    View in: PubMed
  67. Nimchinsky EA, Sabatini BL, Svoboda K. Structure and function of dendritic spines. Annu Rev Physiol. 2002; 64:313-53.
    View in: PubMed
  68. Sabatini BL, Maravall M, Svoboda K. Ca(2+) signaling in dendritic spines. Curr Opin Neurobiol. 2001 Jun; 11(3):349-56.
    View in: PubMed
  69. Sabatini BL, Svoboda K. Analysis of calcium channels in single spines using optical fluctuation analysis. Nature. 2000 Nov 30; 408(6812):589-93.
    View in: PubMed
  70. Maravall M, Mainen ZF, Sabatini BL, Svoboda K. Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophys J. 2000 May; 78(5):2655-67.
    View in: PubMed
  71. Sabatini BL, Regehr WG. Timing of synaptic transmission. Annu Rev Physiol. 1999; 61:521-42.
    View in: PubMed
  72. Sabatini BL, Regehr WG. Optical measurement of presynaptic calcium currents. Biophys J. 1998 Mar; 74(3):1549-63.
    View in: PubMed
  73. Sabatini BL, Regehr WG. Control of neurotransmitter release by presynaptic waveform at the granule cell to Purkinje cell synapse. J Neurosci. 1997 May 15; 17(10):3425-35.
    View in: PubMed
  74. Sabatini BL, Regehr WG. Timing of neurotransmission at fast synapses in the mammalian brain. Nature. 1996 Nov 14; 384(6605):170-2.
    View in: PubMed
  75. Sabatini BL, Regehr WG. Detecting changes in calcium influx which contribute to synaptic modulation in mammalian brain slice. Neuropharmacology. 1995 Nov; 34(11):1453-67.
    View in: PubMed
  76. Mintz IM, Sabatini BL, Regehr WG. Calcium control of transmitter release at a cerebellar synapse. Neuron. 1995 Sep; 15(3):675-88.
    View in: PubMed
  77. Blumenfeld H, Zablow L, Sabatini B. Evaluation of cellular mechanisms for modulation of calcium transients using a mathematical model of fura-2 Ca2+ imaging in Aplysia sensory neurons. Biophys J. 1992 Oct; 63(4):1146-64.
    View in: PubMed
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