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Last Name
Institution

Vikas P. Sukhatme, M.D., PH.D.

TitleVictor J. Aresty Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressChief Academic Officer&HarvardFacultyDeanForAcad Progrm
Beth Israel Deaconess Medical Center, Gryzmish 602
330 Brookline Ave
Boston MA 02215
Phone617/667-9050
Fax617/667-7843

 Mentoring 
 completed student projects
Generating an Optimal Renewable Source of Anti-Angiogenic Activity from Ovarian Cancer Cell Lines
Summer, 07/01/99 - 08/25/99
Effects of Non-Cytotoxic Doses of Taxol on Vascular Endothelial Growth Factor (VEGF) Production by Tumor Cells
Summer, 05/28/01 - 08/31/01
Circulating Factors in Patients with Systemic Inflammatory Response Syndrome(SIRS) and Sepsis
Summer, 06/19/05 - 08/27/05

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE. Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res. 2013 Dec 1; 73(23):7009-21.
    View in: PubMed
  2. Chan B, Sukhatme VP. One-step purification of soluble recombinant human 6-phosphogluconate dehydrogenase from Escherichia coli. Protein Expr Purif. 2013 Nov; 92(1):62-6.
    View in: PubMed
  3. Chan B, Vanderlaan PA, Sukhatme VP. 6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met. Biochem Biophys Res Commun. 2013 Sep 20; 439(2):247-51.
    View in: PubMed
  4. Husain Z, Huang Y, Seth P, Sukhatme VP. Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J Immunol. 2013 Aug 1; 191(3):1486-95.
    View in: PubMed
  5. Hanai JI, Doro N, Seth P, Sukhatme VP. ATP citrate lyase knockdown impacts cancer stem cells in vitro. Cell Death Dis. 2013; 4:e696.
    View in: PubMed
  6. Cerdeira AS, Rajakumar A, Royle CM, Lo A, Husain Z, Thadhani RI, Sukhatme VP, Karumanchi SA, Kopcow HD. Conversion of Peripheral Blood NK Cells to a Decidual NK-like Phenotype by a Cocktail of Defined Factors. J Immunol. 2013 Apr 15; 190(8):3939-48.
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  7. Arnaout R, Buck TP, Roulette P, Sukhatme VP. Predicting the cost and pace of pharmacogenomic advances: an evidence-based study. Clin Chem. 2013 Apr; 59(4):649-57.
    View in: PubMed
  8. Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1 null Mice. Hepatology. 2013 Jan; 57(1):205-16.
    View in: PubMed
  9. Retsky M, Demicheli R, Hrushesky WJ, Forget P, De Kock M, Gukas I, Rogers RA, Baum M, Sukhatme V, Vaidya JS. Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review. Curr Med Chem. 2013; 20(33):4163-76.
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  10. Sukhatme VP, Chan B. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence. FEBS Lett. 2012 Jul 30; 586(16):2389-95.
    View in: PubMed
  11. Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP. Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. J Cell Physiol. 2012 Apr; 227(4):1709-20.
    View in: PubMed
  12. Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK. A small-molecule screening strategy to identify suppressors of statin myopathy. ACS Chem Biol. 2011 Sep 16; 6(9):900-4.
    View in: PubMed
  13. Bhatt RS, Zurita AJ, O'Neill A, Norden-Zfoni A, Zhang L, Wu HK, Wen PY, George D, Sukhatme VP, Atkins MB, Heymach JV. Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma. Br J Cancer. 2011 Jun 28; 105(1):112-7.
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  14. Seth P, Grant A, Tang J, Vinogradov E, Wang X, Lenkinski R, Sukhatme VP. On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate. Neoplasia. 2011 Jan; 13(1):60-71.
    View in: PubMed
  15. Ren JG, Seth P, Everett P, Clish CB, Sukhatme VP. Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2. PLoS One. 2010; 5(9).
    View in: PubMed
  16. Bhatt RS, Merchan J, Parker R, Wu HK, Zhang L, Seery V, Heymach JV, Atkins MB, McDermott D, Sukhatme VP. A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma. Cancer. 2010 Apr 1; 116(7):1751-6.
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  17. Boguski MS, Mandl KD, Sukhatme VP. Drug discovery. Repurposing with a difference. Science. 2009 Jun 12; 324(5933):1394-5.
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  18. Cao P, Hanai J, Tanksale P, Imamura S, Sukhatme VP, Lecker SH. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB J. 2009 Sep; 23(9):2844-54.
    View in: PubMed
  19. Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, Linehan WM, Sukhatme VP, Seth P. LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther. 2009 Mar; 8(3):626-35.
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  20. Chan B, Sukhatme VP. Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function. FEBS Lett. 2009 Mar 18; 583(6):1023-8.
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  21. Chan B, Sukhatme VP. Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. Thromb Res. 2009 Mar; 123(5):745-52.
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  22. Wei F, Karihaloo A, Yu Z, Marlier A, Seth P, Shibazaki S, Wang T, Sukhatme VP, Somlo S, Cantley LG. Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo. Kidney Int. 2008 Nov; 74(10):1310-8.
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  23. Gallagher DC, Parikh SM, Balonov K, Miller A, Gautam S, Talmor D, Sukhatme VP. Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome. Shock. 2008 Jun; 29(6):656-61.
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  24. Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP. Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochem Biophys Res Commun. 2008 Jul 4; 371(3):475-9.
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  25. Bhatt RS, Landis DM, Zimmer M, Torregrossa J, Chen S, Sukhatme VP, Iliopoulos O, Balk S, Bubley GJ. Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor. BJU Int. 2008 Aug; 102(3):358-63.
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  26. Zeidel M, Bonventre J, Forrest J, Sukhatme V. A national course for renal fellows: the origins of renal physiology. J Am Soc Nephrol. 2008 Apr; 19(4):649-50.
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  27. Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest. 2007 Dec; 117(12):3940-51.
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  28. Giuliano JS, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS. Admission angiopoietin levels in children with septic shock. Shock. 2007 Dec; 28(6):650-654.
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  29. Hakimé A, Hines-Peralta A, Peddi H, Atkins MB, Sukhatme VP, Signoretti S, Regan M, Goldberg SN. Combination of radiofrequency ablation with antiangiogenic therapy for tumor ablation efficacy: study in mice. Radiology. 2007 Aug; 244(2):464-70.
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  30. Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007 Aug 17; 282(33):23910-8.
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  31. Yuan HT, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme VP, Woolf AS, Karumanchi SA. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB J. 2007 Oct; 21(12):3171-83.
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  32. Gallagher DC, Bhatt RS, Parikh SM, Patel P, Seery V, McDermott DF, Atkins MB, Sukhatme VP. Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak. Clin Cancer Res. 2007 Apr 1; 13(7):2115-20.
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  33. Atkins MB, Ernstoff MS, Figlin RA, Flaherty KT, George DJ, Kaelin WG, Kwon ED, Libermann TA, Linehan WM, McDermott DF, Ochoa AC, Pantuck AJ, Rini BI, Rosen MA, Sosman JA, Sukhatme VP, Vieweg JW, Wood CG, King L. Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge Conference. Clin Cancer Res. 2007 Jan 15; 13(2 Pt 2):667s-670s.
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  34. Bhatt RS, Seth P, Sukhatme VP. Biomarkers for monitoring antiangiogenic therapy. Clin Cancer Res. 2007 Jan 15; 13(2 Pt 2):777s-780s.
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  35. Venkatesha S, Hanai J, Seth P, Karumanchi SA, Sukhatme VP. Lipocalin 2 antagonizes the proangiogenic action of ras in transformed cells. Mol Cancer Res. 2006 Nov; 4(11):821-9.
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  36. Mochida Y, Parisuthiman D, Kaku M, Hanai J, Sukhatme VP, Yamauchi M. Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signaling. J Biol Chem. 2006 Nov 24; 281(47):36044-51.
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  37. Hu G, Tang J, Zhang B, Lin Y, Hanai J, Galloway J, Bedell V, Bahary N, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP. A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. J Cell Sci. 2006 Oct 1; 119(Pt 19):4117-26.
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  38. Merchan JR, Tang J, Hu G, Lin Y, Mutter W, Tong C, Karumanchi SA, Russell SJ, Sukhatme VP. Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model. J Natl Cancer Inst. 2006 Jun 7; 98(11):756-64.
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  39. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006 Jun; 12(6):642-9.
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  40. Hines-Peralta A, Sukhatme V, Regan M, Signoretti S, Liu ZJ, Goldberg SN. Improved tumor destruction with arsenic trioxide and radiofrequency ablation in three animal models. Radiology. 2006 Jul; 240(1):82-9.
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  41. Roy-Chaudhury P, Sukhatme VP, Cheung AK. Hemodialysis vascular access dysfunction: a cellular and molecular viewpoint. J Am Soc Nephrol. 2006 Apr; 17(4):1112-27.
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  42. Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 2006 Mar; 3(3):e46.
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  43. Tang J, Hu G, Hanai J, Yadlapalli G, Lin Y, Zhang B, Galloway J, Bahary N, Sinha S, Thisse B, Thisse C, Jin JP, Zon LI, Sukhatme VP. A critical role for calponin 2 in vascular development. J Biol Chem. 2006 Mar 10; 281(10):6664-72.
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  44. Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP. Magic roundabout, a tumor endothelial marker: expression and signaling. Biochem Biophys Res Commun. 2005 Jul 1; 332(2):533-41.
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  45. Karumanchi SA, Maynard SE, Stillman IE, Epstein FH, Sukhatme VP. Preeclampsia: a renal perspective. Kidney Int. 2005 Jun; 67(6):2101-13.
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  46. Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R. roundabout4 is essential for angiogenesis in vivo. Proc Natl Acad Sci U S A. 2005 May 3; 102(18):6373-8.
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  47. Zacharski LR, Sukhatme VP. Coley's toxin revisited: immunotherapy or plasminogen activator therapy of cancer? J Thromb Haemost. 2005 Mar; 3(3):424-7.
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  48. Hanai J, Mammoto T, Seth P, Mori K, Karumanchi SA, Barasch J, Sukhatme VP. Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. J Biol Chem. 2005 Apr 8; 280(14):13641-7.
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  49. Merchan JR, Jayaram DR, Supko JG, He X, Bubley GJ, Sukhatme VP. Increased endothelial uptake of paclitaxel as a potential mechanism for its antiangiogenic effects: potentiation by Cox-2 inhibition. Int J Cancer. 2005 Jan 20; 113(3):490-8.
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  50. Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, Blink AL, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Urinary placental growth factor and risk of preeclampsia. JAMA. 2005 Jan 5; 293(1):77-85.
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  51. Chan B, Sinha S, Cho D, Ramchandran R, Sukhatme VP. Critical roles of CD146 in zebrafish vascular development. Dev Dyn. 2005 Jan; 232(1):232-44.
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  52. Kale S, Hanai J, Chan B, Karihaloo A, Grotendorst G, Cantley L, Sukhatme VP. Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression. FASEB J. 2005 Feb; 19(2):270-1.
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  53. Wolf M, Hubel CA, Lam C, Sampson M, Ecker JL, Ness RB, Rajakumar A, Daftary A, Shakir AS, Seely EW, Roberts JM, Sukhatme VP, Karumanchi SA, Thadhani R. Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance. J Clin Endocrinol Metab. 2004 Dec; 89(12):6239-43.
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  54. Bdolah Y, Sukhatme VP, Karumanchi SA. Angiogenic imbalance in the pathophysiology of preeclampsia: newer insights. Semin Nephrol. 2004 Nov; 24(6):548-56.
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  55. Thadhani R, Ecker JL, Mutter WP, Wolf M, Smirnakis KV, Sukhatme VP, Levine RJ, Karumanchi SA. Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia. Hypertension. 2004 May; 43(5):988-92.
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  56. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004 Feb 12; 350(7):672-83.
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  57. Feinberg MW, Watanabe M, Lebedeva MA, Depina AS, Hanai J, Mammoto T, Frederick JP, Wang XF, Sukhatme VP, Jain MK. Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. J Biol Chem. 2004 Apr 16; 279(16):16388-93.
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  58. Thadhani R, Mutter WP, Wolf M, Levine RJ, Taylor RN, Sukhatme VP, Ecker J, Karumanchi SA. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab. 2004 Feb; 89(2):770-5.
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  59. Chan B, Merchan JR, Kale S, Sukhatme VP. Antiangiogenic property of human thrombin. Microvasc Res. 2003 Jul; 66(1):1-14.
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  60. McDonald GA, Sarkar P, Rennke H, Unemori E, Kalluri R, Sukhatme VP. Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo. Am J Physiol Renal Physiol. 2003 Jul; 285(1):F59-67.
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  61. Merchan JR, Chan B, Kale S, Schnipper LE, Sukhatme VP. In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril. J Natl Cancer Inst. 2003 Mar 5; 95(5):388-99.
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  62. Strom TB, Sukhatme VP. A refined understanding of immunosuppressives and cancer risk. Kidney Int. 2003 Mar; 63(3):1160-1.
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  63. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003 Mar; 111(5):649-58.
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  64. Lin LF, Zhu G, Yoo JJ, Soker S, Sukhatme VP, Atala A. A system for the enhancement of adenovirus mediated gene transfer to uro-epithelium. J Urol. 2002 Aug; 168(2):813-8.
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  65. Hanai J, Gloy J, Karumanchi SA, Kale S, Tang J, Hu G, Chan B, Ramchandran R, Jha V, Sukhatme VP, Sokol S. Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol. 2002 Aug 5; 158(3):529-39.
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  66. Hanai J, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, Ramchandran R, Pestell R, Sukhatme VP. Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J Biol Chem. 2002 May 10; 277(19):16464-9.
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  67. Karumanchi SA, Merchan J, Sukhatme VP. Renal cancer: molecular mechanisms and newer therapeutic options. Curr Opin Nephrol Hypertens. 2002 Jan; 11(1):37-42.
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  68. Ramchandran R, Karumanchi SA, Hanai J, Alper SL, Sukhatme VP. Cellular actions and signaling by endostatin. Crit Rev Eukaryot Gene Expr. 2002; 12(3):175-91.
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  69. Karihaloo A, Karumanchi SA, Barasch J, Jha V, Nickel CH, Yang J, Grisaru S, Bush KT, Nigam S, Rosenblum ND, Sukhatme VP, Cantley LG. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12509-14.
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  70. Wagner KD, Wagner N, Sukhatme VP, Scholz H. Activation of vitamin D receptor by the Wilms' tumor gene product mediates apoptosis of renal cells. J Am Soc Nephrol. 2001 Jun; 12(6):1188-96.
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  71. Jiang L, Jha V, Dhanabal M, Sukhatme VP, Alper SL. Intracellular Ca(2+) signaling in endothelial cells by the angiogenesis inhibitors endostatin and angiostatin. Am J Physiol Cell Physiol. 2001 May; 280(5):C1140-50.
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  72. Karumanchi SA, Jiang L, Knebelmann B, Stuart-Tilley AK, Alper SL, Sukhatme VP. VHL tumor suppressor regulates Cl-/HCO3- exchange and Na+/H+ exchange activities in renal carcinoma cells. Physiol Genomics. 2001 Apr 2; 5(3):119-28.
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  73. Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP. Cell surface glypicans are low-affinity endostatin receptors. Mol Cell. 2001 Apr; 7(4):811-22.
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  74. Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature. 2000 Dec 21-28; 408(6815):990-4.
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  75. Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramchandran R, Kalluri R, Sukhatme VP, Kufe DW, Weichselbaum RR. Antitumor interaction of short-course endostatin and ionizing radiation. Cancer J. 2000 Sep-Oct; 6(5):287-93.
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  76. Yokoyama Y, Green JE, Sukhatme VP, Ramakrishnan S. Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinoma in a transgenic mouse model. Cancer Res. 2000 Aug 15; 60(16):4362-5.
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  77. Kalluri R, Sukhatme VP. Fibrosis and angiogenesis. Curr Opin Nephrol Hypertens. 2000 Jul; 9(4):413-8.
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  78. Hari D, Beckett MA, Sukhatme VP, Dhanabal M, Nodzenski E, Lu H, Mauceri HJ, Kufe DW, Weichselbaum RR. Angiostatin induces mitotic cell death of proliferating endothelial cells. Mol Cell Biol Res Commun. 2000 May; 3(5):277-82.
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  79. Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R. Anti-angiogenic cues from vascular basement membrane collagen. Cancer Res. 2000 May 1; 60(9):2520-6.
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  80. Yokoyama Y, Dhanabal M, Griffioen AW, Sukhatme VP, Ramakrishnan S. Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth. Cancer Res. 2000 Apr 15; 60(8):2190-6.
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  81. Kamphaus GD, Colorado PC, Panka DJ, Hopfer H, Ramchandran R, Torre A, Maeshima Y, Mier JW, Sukhatme VP, Kalluri R. Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. J Biol Chem. 2000 Jan 14; 275(2):1209-15.
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  82. Sukhatme VP. Training the academic nephrologist for the new millennium. Semin Nephrol. 2000 Jan; 20(1):87-91.
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  83. Cohen HT, Zhou M, Welsh AM, Zarghamee S, Scholz H, Mukhopadhyay D, Kishida T, Zbar B, Knebelmann B, Sukhatme VP. An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association. Biochem Biophys Res Commun. 1999 Dec 9; 266(1):43-50.
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  84. Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G. Interaction between RGS7 and polycystin. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6371-6.
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  85. Lu H, Dhanabal M, Volk R, Waterman MJ, Ramchandran R, Knebelmann B, Segal M, Sukhatme VP. Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells. Biochem Biophys Res Commun. 1999 May 19; 258(3):668-73.
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  86. Dhanabal M, Volk R, Ramchandran R, Simons M, Sukhatme VP. Cloning, expression, and in vitro activity of human endostatin. Biochem Biophys Res Commun. 1999 May 10; 258(2):345-52.
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  87. Ananth S, Knebelmann B, Grüning W, Dhanabal M, Walz G, Stillman IE, Sukhatme VP. Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma. Cancer Res. 1999 May 1; 59(9):2210-6.
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  88. Dhanabal M, Ramchandran R, Waterman MJ, Lu H, Knebelmann B, Segal M, Sukhatme VP. Endostatin induces endothelial cell apoptosis. J Biol Chem. 1999 Apr 23; 274(17):11721-6.
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  89. Morawietz H, Ma YH, Vives F, Wilson E, Sukhatme VP, Holtz J, Ives HE. Rapid induction and translocation of Egr-1 in response to mechanical strain in vascular smooth muscle cells. Circ Res. 1999 Apr 2; 84(6):678-87.
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  90. Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP. Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3934-9.
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  91. McDonald GA, Zhu G, Li Y, Kovesdi I, Wickham TJ, Sukhatme VP. Efficient adenoviral gene transfer to kidney cortical vasculature utilizing a fiber modified vector. J Gene Med. 1999 Mar-Apr; 1(2):103-10.
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  92. Ramchandran R, Dhanabal M, Volk R, Waterman MJ, Segal M, Lu H, Knebelmann B, Sukhatme VP. Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. Biochem Biophys Res Commun. 1999 Feb 24; 255(3):735-9.
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  93. Cook J, Krishnan S, Ananth S, Sells SF, Shi Y, Walther MM, Linehan WM, Sukhatme VP, Weinstein MH, Rangnekar VM. Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene. 1999 Feb 4; 18(5):1205-8.
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  94. Thottassery JV, Sun D, Zambetti GP, Troutman A, Sukhatme VP, Schuetz EG, Schuetz JD. Sp1 and egr-1 have opposing effects on the regulation of the rat Pgp2/mdr1b gene. J Biol Chem. 1999 Jan 29; 274(5):3199-206.
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  95. Kelley VR, Sukhatme VP. Gene transfer in the kidney. Am J Physiol. 1999 Jan; 276(1 Pt 2):F1-9.
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  96. Dhanabal M, Ramchandran R, Volk R, Stillman IE, Lombardo M, Iruela-Arispe ML, Simons M, Sukhatme VP. Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma. Cancer Res. 1999 Jan 1; 59(1):189-97.
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  97. Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum RR. Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Res. 1998 Dec 15; 58(24):5686-9.
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  98. Drummond IA, Mukhopadhyay D, Sukhatme VP. Expression of fetal kidney growth factors in a kidney tumor line: role of FGF2 in kidney development. Exp Nephrol. 1998 Nov-Dec; 6(6):522-33.
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  99. Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, Bigelow K, Heimann R, Gately S, Dhanabal M, Soff GA, Sukhatme VP, Kufe DW, Weichselbaum RR. Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature. 1998 Jul 16; 394(6690):287-91.
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  100. Schwachtgen JL, Houston P, Campbell C, Sukhatme V, Braddock M. Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway. J Clin Invest. 1998 Jun 1; 101(11):2540-9.
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  101. Knebelmann B, Ananth S, Cohen HT, Sukhatme VP. Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor. Cancer Res. 1998 Jan 15; 58(2):226-31.
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  102. Mukhopadhyay D, Tsiokas L, Sukhatme VP. High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation. Gene Expr. 1998; 7(1):53-60.
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  103. Scholz H, Bossone SA, Cohen HT, Akella U, Strauss WM, Sukhatme VP. A far upstream cis-element is required for Wilms' tumor-1 (WT1) gene expression in renal cell culture. J Biol Chem. 1997 Dec 26; 272(52):32836-46.
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  104. Zhu G, Nicolson AG, Zheng XX, Strom TB, Sukhatme VP. Adenovirus-mediated beta-galactosidase gene delivery to the liver leads to protein deposition in kidney glomeruli. Kidney Int. 1997 Oct; 52(4):992-9.
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  105. Mukhopadhyay D, Knebelmann B, Cohen HT, Ananth S, Sukhatme VP. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol Cell Biol. 1997 Sep; 17(9):5629-39.
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  106. Drummond IA, Goodyer P, Sukhatme VP. Immortal, developmentally arrested human fetal kidney cell lines created by retroviral expression of human papilloma virus E6 and E7. Exp Nephrol. 1997 Sep-Oct; 5(5):390-8.
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  107. Nair P, Muthukkumar S, Sells SF, Han SS, Sukhatme VP, Rangnekar VM. Early growth response-1-dependent apoptosis is mediated by p53. J Biol Chem. 1997 Aug 8; 272(32):20131-8.
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  108. Sells SF, Han SS, Muthukkumar S, Maddiwar N, Johnstone R, Boghaert E, Gillis D, Liu G, Nair P, Monnig S, Collini P, Mattson MP, Sukhatme VP, Zimmer SG, Wood DP, McRoberts JW, Shi Y, Rangnekar VM. Expression and function of the leucine zipper protein Par-4 in apoptosis. Mol Cell Biol. 1997 Jul; 17(7):3823-32.
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  109. Tsiokas L, Kim E, Arnould T, Sukhatme VP, Walz G. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6965-70.
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  110. Muruve DA, Nicolson AG, Manfro RC, Strom TB, Sukhatme VP, Libermann TA. Adenovirus-mediated expression of Fas ligand induces hepatic apoptosis after Systemic administration and apoptosis of ex vivo-infected pancreatic islet allografts and isografts. Hum Gene Ther. 1997 May 20; 8(8):955-63.
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  111. Sukhatme VP, Cowley BD, Zhu G. Gene transfer into kidney tubules and vasculature by adenoviral vectors. Exp Nephrol. 1997 Mar-Apr; 5(2):137-43.
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  112. Cohen HT, Bossone SA, Zhu G, McDonald GA, Sukhatme VP. Sp1 is a critical regulator of the Wilms' tumor-1 gene. J Biol Chem. 1997 Jan 31; 272(5):2901-13.
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  113. Sukhatme VP. Gene therapy for kidney disease. Adv Nephrol Necker Hosp. 1997; 26:73-80.
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  114. Hofer G, Grimmer C, Sukhatme VP, Sterzel RB, Rupprecht HD. Transcription factor Egr-1 regulates glomerular mesangial cell proliferation. J Biol Chem. 1996 Nov 8; 271(45):28306-10.
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  115. Zhu G, Nicolson AG, Cowley BD, Rosen S, Sukhatme VP. In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys. Gene Ther. 1996 Apr; 3(4):298-304.
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  116. Sukhatme VP. Vascular access stenosis: prospects for prevention and therapy. Kidney Int. 1996 Apr; 49(4):1161-74.
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  117. Hallahan DE, Dunphy E, Virudachalam S, Sukhatme VP, Kufe DW, Weichselbaum RR. C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure. J Biol Chem. 1995 Dec 22; 270(51):30303-9.
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  118. Kinane TB, Finder JD, Kawashima A, Brown D, Abbate M, Fredericks WJ, Sukhatme VP, Rauscher FJ, Ercolani L. LLC-PK1 cell growth is repressed by WT1 inhibition of G-protein alpha i-2 protooncogene transcription. J Biol Chem. 1995 Dec 22; 270(51):30760-4.
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  119. Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res. 1995 Dec 15; 55(24):6161-5.
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  120. Levin WJ, Press MF, Gaynor RB, Sukhatme VP, Boone TC, Reissmann PT, Figlin RA, Holmes EC, Souza LM, Slamon DJ. Expression patterns of immediate early transcription factors in human non-small cell lung cancer. The Lung Cancer Study Group. Oncogene. 1995 Oct 5; 11(7):1261-9.
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  121. Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995 Jun 15; 375(6532):577-81.
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  122. Prasadan K, Bates J, Badgett A, Dell M, Sukhatme V, Yu H, Kumar S. Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine. Biochim Biophys Acta. 1995 Feb 21; 1260(3):328-32.
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  123. Sells SF, Muthukumar S, Sukhatme VP, Crist SA, Rangnekar VM. The zinc finger transcription factor EGR-1 impedes interleukin-1-inducible tumor growth arrest. Mol Cell Biol. 1995 Feb; 15(2):682-92.
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  124. Gashler A, Sukhatme VP. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog Nucleic Acid Res Mol Biol. 1995; 50:191-224.
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  125. Kinane TB, Finder JD, Kawashima A, Brown D, Abbate M, Shang C, Fredericks WJ, Rauscher FJ, Sukhatme VP, Ercolani L. Growth of LLC-PK1 renal cells is mediated by EGR-1 up-regulation of G protein alpha i-2 protooncogene transcription. J Biol Chem. 1994 Nov 4; 269(44):27503-9.
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  126. Drummond IA, Rohwer-Nutter P, Sukhatme VP. The zebrafish egr1 gene encodes a highly conserved, zinc-finger transcriptional regulator. DNA Cell Biol. 1994 Oct; 13(10):1047-55.
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  127. Drummond IA, Rohwer-Nutter P, Sukhatme VP. The zebrafish egr1 gene encodes a highly conserved, zinc-finger transcriptional regulator. DNA Cell Biol. 1994 Sep; 13(9):953-61.
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  128. Ebert SN, Balt SL, Hunter JP, Gashler A, Sukhatme V, Wong DL. Egr-1 activation of rat adrenal phenylethanolamine N-methyltransferase gene. J Biol Chem. 1994 Aug 19; 269(33):20885-98.
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  129. Maass A, Grohé C, Oberdorf S, Sukhatme VP, Vetter H, Neyses L. Mitogenic signals control translation of the early growth response gene-1 in myogenic cells. Biochem Biophys Res Commun. 1994 Aug 15; 202(3):1337-46.
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  130. Weichselbaum RR, Hallahan DE, Beckett MA, Mauceri HJ, Lee H, Sukhatme VP, Kufe DW. Gene therapy targeted by radiation preferentially radiosensitizes tumor cells. Cancer Res. 1994 Aug 15; 54(16):4266-9.
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  131. Drummond IA, Rupprecht HD, Rohwer-Nutter P, Lopez-Guisa JM, Madden SL, Rauscher FJ, Sukhatme VP. DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1. Mol Cell Biol. 1994 Jun; 14(6):3800-9.
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  132. Dey BR, Sukhatme VP, Roberts AB, Sporn MB, Rauscher FJ, Kim SJ. Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product. Mol Endocrinol. 1994 May; 8(5):595-602.
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  133. Rupprecht HD, Sukhatme VP, Rupprecht AP, Sterzel RB, Coleman DL. Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene-1 by arginine vasopressin in rat mesangial cells. J Cell Physiol. 1994 May; 159(2):311-23.
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  134. Werner H, Rauscher FJ, Sukhatme VP, Drummond IA, Roberts CT, LeRoith D. Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site. J Biol Chem. 1994 Apr 29; 269(17):12577-82.
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  135. Chauhan D, Kharbanda SM, Uchiyama H, Sukhatme VP, Kufe DW, Anderson KC. Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells. Cancer Res. 1994 Apr 15; 54(8):2234-9.
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  136. Kharbanda S, Saleem A, Hirano M, Emoto Y, Sukhatme V, Blenis J, Kufe D. Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation. Cell Growth Differ. 1994 Mar; 5(3):259-65.
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  137. Rupprecht HD, Drummond IA, Madden SL, Rauscher FJ, Sukhatme VP. The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J Biol Chem. 1994 Feb 25; 269(8):6198-206.
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  138. Yu H, Papa F, Sukhatme VP. Bovine and rodent tamm-horsfall protein (THP) genes: cloning, structural analysis, and promoter identification. Gene Expr. 1994; 4(1-2):63-75.
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  139. Kharbanda S, Saleem A, Rubin E, Sukhatme V, Blenis J, Kufe D. Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(beta-D-arabinofuranosyl)cytosine. Biochemistry. 1993 Sep 7; 32(35):9137-42.
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  140. Rupprecht HD, Sukhatme VP, Lacy J, Sterzel RB, Coleman DL. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. Am J Physiol. 1993 Sep; 265(3 Pt 2):F351-60.
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  141. Neyses L, Nouskas J, Luyken J, Fronhoffs S, Oberdorf S, Pfeifer U, Williams RS, Sukhatme VP, Vetter H. Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes. J Hypertens. 1993 Sep; 11(9):927-34.
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  142. Sukhatme VP. Renal development: challenge and opportunity. Semin Nephrol. 1993 Sep; 13(5):422-6.
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  143. Gashler AL, Swaminathan S, Sukhatme VP. A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol Cell Biol. 1993 Aug; 13(8):4556-71.
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  144. Werner H, Re GG, Drummond IA, Sukhatme VP, Rauscher FJ, Sens DA, Garvin AJ, LeRoith D, Roberts CT. Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5828-32.
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  145. Datta R, Taneja N, Sukhatme VP, Qureshi SA, Weichselbaum R, Kufe DW. Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2419-22.
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  146. Hallahan DE, Gius D, Kuchibhotla J, Sukhatme V, Kufe DW, Weichselbaum RR. Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor. J Biol Chem. 1993 Mar 5; 268(7):4903-7.
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  147. Landis CA, Collins BJ, Cribbs LL, Sukhatme VP, Bergmann BM, Rechtschaffen A, Smalheiser NR. Expression of Egr-1 in the brain of sleep deprived rats. Brain Res Mol Brain Res. 1993 Mar; 17(3-4):300-6.
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  148. Kharbanda S, Rubin E, Datta R, Hass R, Sukhatme V, Kufe D. Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid. Cell Growth Differ. 1993 Jan; 4(1):17-23.
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  149. Gashler AL, Bonthron DT, Madden SL, Rauscher FJ, Collins T, Sukhatme VP. Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10984-8.
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  150. Datta R, Rubin E, Sukhatme V, Qureshi S, Hallahan D, Weichselbaum RR, Kufe DW. Ionizing radiation activates transcription of the EGR1 gene via CArG elements. Proc Natl Acad Sci U S A. 1992 Nov 1; 89(21):10149-53.
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  151. Cohen HT, Sukhatme VP. Molecular biology in nephrology: an overview with emphasis on the study of renal cancer. Semin Nephrol. 1992 Nov; 12(6):495-505.
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  152. Coleman DL, Bartiss AH, Sukhatme VP, Liu J, Rupprecht HD. Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages. J Immunol. 1992 Nov 1; 149(9):3045-51.
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  153. Rupprecht HD, Dann P, Sukhatme VP, Sterzel RB, Coleman DL. Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity. Am J Physiol. 1992 Oct; 263(4 Pt 2):F623-36.
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  154. Rim M, Qureshi SA, Gius D, Nho J, Sukhatme VP, Foster DA. Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements. Oncogene. 1992 Oct; 7(10):2065-8.
    View in: PubMed
  155. Drummond IA, Madden SL, Rohwer-Nutter P, Bell GI, Sukhatme VP, Rauscher FJ. Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science. 1992 Jul 31; 257(5070):674-8.
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  156. Alexandropoulos K, Qureshi SA, Rim M, Sukhatme VP, Foster DA. v-Fps-responsiveness in the Egr-1 promoter is mediated by serum response elements. Nucleic Acids Res. 1992 May 11; 20(9):2355-9.
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  157. Trabandt A, Gay RE, Sukhatme VP, Gay S. Expression of collagenase and potential transcriptional factors c-fos and egr-1 in periodontal gingival fibroblasts. J Oral Pathol Med. 1992 May; 21(5):232-40.
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  158. Sukhatme VP. The Egr transcription factor family: from signal transduction to kidney differentiation. Kidney Int. 1992 Mar; 41(3):550-3.
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  159. Fukuoka S, Freedman SD, Yu H, Sukhatme VP, Scheele GA. GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1189-93.
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  160. Alexander-Bridges M, Buggs C, Giere L, Denaro M, Kahn B, White M, Sukhatme V, Nasrin N. Models of insulin action on metabolic and growth response genes. Mol Cell Biochem. 1992 Feb 12; 109(2):99-105.
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  161. Cao XM, Guy GR, Sukhatme VP, Tan YH. Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts. J Biol Chem. 1992 Jan 15; 267(2):1345-9.
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  162. Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Fassbender HG, Gay S. Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts. Rheumatol Int. 1992; 12(2):53-9.
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  163. Weichselbaum RR, Hallahan DE, Sukhatme VP, Kufe DW. Gene therapy targeted by ionizing radiation. Int J Radiat Oncol Biol Phys. 1992; 24(3):565-7.
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  164. Qureshi SA, Rim MH, Alexandropoulos K, Berg K, Sukhatme VP, Foster DA. Sustained induction of egr-1 by v-src correlates with a lack of fos-mediated repression of the egr-1 promoter. Oncogene. 1992 Jan; 7(1):121-5.
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  165. Morris JF, Madden SL, Tournay OE, Cook DM, Sukhatme VP, Rauscher FJ. Characterization of the zinc finger protein encoded by the WT1 Wilms' tumor locus. Oncogene. 1991 Dec; 6(12):2339-48.
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  166. Qureshi SA, Rim M, Bruder J, Kolch W, Rapp U, Sukhatme VP, Foster DA. An inhibitory mutant of c-Raf-1 blocks v-Src-induced activation of the Egr-1 promoter. J Biol Chem. 1991 Nov 5; 266(31):20594-7.
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  167. Madden SL, Cook DM, Morris JF, Gashler A, Sukhatme VP, Rauscher FJ. Transcriptional repression mediated by the WT1 Wilms tumor gene product. Science. 1991 Sep 27; 253(5027):1550-3.
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  168. Kharbanda S, Nakamura T, Stone R, Hass R, Bernstein S, Datta R, Sukhatme VP, Kufe D. Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation. J Clin Invest. 1991 Aug; 88(2):571-7.
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  169. Darland T, Samuels M, Edwards SA, Sukhatme VP, Adamson ED. Regulation of Egr-1 (Zfp-6) and c-fos expression in differentiating embryonal carcinoma cells. Oncogene. 1991 Aug; 6(8):1367-76.
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  170. Eghbali M, Tomek R, Sukhatme VP, Woods C, Bhambi B. Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mRNAs and expression of early transcription factors. Circ Res. 1991 Aug; 69(2):483-90.
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  171. Gupta MP, Gupta M, Zak R, Sukhatme VP. Egr-1, a serum-inducible zinc finger protein, regulates transcription of the rat cardiac alpha-myosin heavy chain gene. J Biol Chem. 1991 Jul 15; 266(20):12813-6.
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  172. Qureshi SA, Cao XM, Sukhatme VP, Foster DA. v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements. J Biol Chem. 1991 Jun 15; 266(17):10802-6.
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  173. Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP. EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene. 1991 Jun; 6(6):917-28.
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  174. Bernstein SH, Kharbanda SM, Sherman ML, Sukhatme VP, Kufe DW. Posttranscriptional regulation of the zinc finger-encoding EGR-1 gene by granulocyte-macrophage colony-stimulating factor in human U-937 monocytic leukemia cells: involvement of a pertussis toxin-sensitive G protein. Cell Growth Differ. 1991 Jun; 2(6):273-8.
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  175. Sukhatme VP. The Egr family of nuclear signal transducers. Am J Kidney Dis. 1991 Jun; 17(6):615-8.
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  176. Weichselbaum RR, Hallahan DE, Sukhatme V, Dritschilo A, Sherman ML, Kufe DW. Biological consequences of gene regulation after ionizing radiation exposure. J Natl Cancer Inst. 1991 Apr 3; 83(7):480-4.
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  177. Liu JW, Lacy J, Sukhatme VP, Coleman DL. Granulocyte-macrophage colony-stimulating factor induces transcriptional activation of Egr-1 in murine peritoneal macrophages. J Biol Chem. 1991 Mar 25; 266(9):5929-33.
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  178. Hallahan DE, Sukhatme VP, Sherman ML, Virudachalam S, Kufe D, Weichselbaum RR. Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2156-60.
    View in: PubMed
  179. Makover D, Cuddy M, Yum S, Bradley K, Alpers J, Sukhatme V, Reed JC. Phorbol ester-mediated inhibition of growth and regulation of proto-oncogene expression in the human T cell leukemia line JURKAT. Oncogene. 1991 Mar; 6(3):455-60.
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  180. Yellen AJ, Glenn W, Sukhatme VP, Cao XM, Monroe JG. Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice. J Immunol. 1991 Mar 1; 146(5):1446-54.
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  181. Bonventre JV, Sukhatme VP, Bamberger M, Ouellette AJ, Brown D. Localization of the protein product of the immediate early growth response gene, Egr-1, in the kidney after ischemia and reperfusion. Cell Regul. 1991 Mar; 2(3):251-60.
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  182. Sukhatme VP. Early transcriptional events in cell growth: the Egr family. J Am Soc Nephrol. 1990 Dec; 1(6):859-66.
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  183. Seyfert VL, McMahon S, Glenn W, Cao XM, Sukhatme VP, Monroe JG. Egr-1 expression in surface Ig-mediated B cell activation. Kinetics and association with protein kinase C activation. J Immunol. 1990 Dec 1; 145(11):3647-53.
    View in: PubMed
  184. Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Nilson-Hamilton M, Hamilton RT, McGhee JR, Fassbender HG, Gay S. Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. Matrix. 1990 Dec; 10(6):349-61.
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  185. Seyfert VL, McMahon SB, Glenn WD, Yellen AJ, Sukhatme VP, Cao XM, Monroe JG. Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction. Science. 1990 Nov 9; 250(4982):797-800.
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  186. Wu JS, Myers S, Carson N, Kidd JR, Anderson L, Castiglione CM, Hoyle LS, Lichter JB, Sukhatme VP, Simpson NE, et al. A refined linkage map for DNA markers around the pericentromeric region of chromosome 10. Genomics. 1990 Nov; 8(3):461-8.
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  187. Iwaki K, Sukhatme VP, Shubeita HE, Chien KR. Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response. J Biol Chem. 1990 Aug 15; 265(23):13809-17.
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  188. Gius D, Cao XM, Rauscher FJ, Cohen DR, Curran T, Sukhatme VP. Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements. Mol Cell Biol. 1990 Aug; 10(8):4243-55.
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  189. Suggs SV, Katzowitz JL, Tsai-Morris C, Sukhatme VP. cDNA sequence of the human cellular early growth response gene Egr-1. Nucleic Acids Res. 1990 Jul 25; 18(14):4283.
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  190. Rangnekar VM, Aplin AC, Sukhatme VP. The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein. Nucleic Acids Res. 1990 May 11; 18(9):2749-57.
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  191. Cao XM, Koski RA, Gashler A, McKiernan M, Morris CF, Gaffney R, Hay RV, Sukhatme VP. Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals. Mol Cell Biol. 1990 May; 10(5):1931-9.
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  192. Ouellette AJ, Malt RA, Sukhatme VP, Bonventre JV. Expression of two "immediate early" genes, Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertrophy in mice. J Clin Invest. 1990 Mar; 85(3):766-71.
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  193. Krieger NS, Sukhatme VP, Bushinsky DA. Conditioned medium from ras oncogene-transformed NIH 3T3 cells induces bone resorption in vitro. J Bone Miner Res. 1990 Feb; 5(2):159-64.
    View in: PubMed
  194. McMahon AP, Champion JE, McMahon JA, Sukhatme VP. Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues. Development. 1990 Feb; 108(2):281-7.
    View in: PubMed
  195. Jamieson GA, Mayforth RD, Villereal ML, Sukhatme VP. Multiple intracellular pathways induce expression of a zinc-finger encoding gene (EGR1): relationship to activation of the Na/H exchanger. J Cell Physiol. 1989 May; 139(2):262-8.
    View in: PubMed
  196. Seyfert VL, Sukhatme VP, Monroe JG. Differential expression of a zinc finger-encoding gene in response to positive versus negative signaling through receptor immunoglobulin in murine B lymphocytes. Mol Cell Biol. 1989 May; 9(5):2083-8.
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  197. Reilly JJ, Mason RW, Chen P, Joseph LJ, Sukhatme VP, Yee R, Chapman HA. Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages. Biochem J. 1989 Jan 15; 257(2):493-8.
    View in: PubMed
  198. Varnum BC, Lim RW, Sukhatme VP, Herschman HR. Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate. Oncogene. 1989 Jan; 4(1):119-20.
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  199. Wu J, Joseph L, Sukhatme VP, Kidd KK. A HindIII polymorphism identified by the human early growth response gene 2 (EGR2) on chromosome 10. Nucleic Acids Res. 1988 Dec 23; 16(24):11855.
    View in: PubMed
  200. Joseph LJ, Le Beau MM, Jamieson GA, Acharya S, Shows TB, Rowley JD, Sukhatme VP. Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7164-8.
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  201. Tsai-Morris CH, Cao XM, Sukhatme VP. 5' flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene. Nucleic Acids Res. 1988 Sep 26; 16(18):8835-46.
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  202. Hirsch S, Strauss A, Masood K, Lee S, Sukhatme V, Gluck S. Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1988 May; 85(9):3004-8.
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  203. Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. J Clin Invest. 1988 May; 81(5):1621-9.
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  204. Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T, et al. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988 Apr 8; 53(1):37-43.
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  205. Sukhatme VP, Kartha S, Toback FG, Taub R, Hoover RG, Tsai-Morris CH. A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens. Oncogene Res. 1987 Sep-Oct; 1(4):343-55.
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  206. Kartha S, Sukhatme VP, Toback FG. ADP activates protooncogene expression in renal epithelial cells. Am J Physiol. 1987 Jun; 252(6 Pt 2):F1175-9.
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  207. Joseph L, Lapid S, Sukhatme V. The major ras induced protein in NIH3T3 cells is cathepsin L. Nucleic Acids Res. 1987 Apr 10; 15(7):3186.
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  208. Reder AT, Antel JP, Singh S, Stoklosa C, Sukhatme V. Molecular analysis of the CD8 gene in multiple sclerosis. J Neuroimmunol. 1987 Mar; 14(2):183-7.
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  209. Parnes JR, Sizer KC, Sukhatme VP, Hunkapiller T. Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone. Behring Inst Mitt. 1985 Aug; (77):48-55.
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  210. Sukhatme VP, Sizer KC, Vollmer AC, Hunkapiller T, Parnes JR. The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions. Cell. 1985 Mar; 40(3):591-7.
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  211. Sukhatme VP, Vollmer AC, Erikson J, Isobe M, Croce C, Parnes JR. Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2. J Exp Med. 1985 Feb 1; 161(2):429-34.
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  212. Kavathas P, Sukhatme VP, Herzenberg LA, Parnes JR. Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7688-92.
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