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Piotr Sliz, Ph.D.

TitleAssociate Professor of Pediatrics
InstitutionHarvard Medical School
DepartmentPediatrics
AddressHarvard Medical School
BCMP, Rm SGM-130
250 Longwood Ave
Boston MA 02115
Phone617/432-5608
Fax617/432-5600
Other Positions
TitleAssociate Professor of Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology


 Research 
 research resources
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 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Morin A, Sliz P. Structural biology computing: Lessons for the biomedical research sciences. Biopolymers. 2013 Nov; 99(11):809-16.
    View in: PubMed
  2. Morin A, Eisenbraun B, Key J, Sanschagrin PC, Timony MA, Ottaviano M, Sliz P. Collaboration gets the most out of software. Elife. 2013; 2:e01456.
    View in: PubMed
  3. Sliz P, Morin A. Optimizing peer review of software code. Science. 2013 Jul 19; 341(6143):236-7.
    View in: PubMed
  4. Morin A, Urban J, Sliz P. A quick guide to software licensing for the scientist-programmer. PLoS Comput Biol. 2012; 8(7):e1002598.
    View in: PubMed
  5. Morin A, Urban J, Adams PD, Foster I, Sali A, Baker D, Sliz P. Research priorities. Shining light into black boxes. Science. 2012 Apr 13; 336(6078):159-60.
    View in: PubMed
  6. Stokes-Rees I, Levesque I, Murphy FV, Yang W, Deacon A, Sliz P. Adapting federated cyberinfrastructure for shared data collection facilities in structural biology. J Synchrotron Radiat. 2012 May; 19(Pt 3):462-7.
    View in: PubMed
  7. O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schröder GF, Brunger AT, Sliz P. A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr. 2012 Mar; 68(Pt 3):261-7.
    View in: PubMed
  8. Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC. Conformational locking upon cooperative assembly of notch transcription complexes. Structure. 2012 Feb 8; 20(2):340-9.
    View in: PubMed
  9. Jiang J, Lazarus MB, Pasquina L, Sliz P, Walker S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nat Chem Biol. 2012 Jan; 8(1):72-7.
    View in: PubMed
  10. Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91.
    View in: PubMed
  11. Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 2011 Jan 27; 469(7331):564-7.
    View in: PubMed
  12. Stokes-Rees I, Sliz P. Protein structure determination by exhaustive search of Protein Data Bank derived databases. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21476-81.
    View in: PubMed
  13. Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chem Biol. 2010 Jul 16; 5(7):701-11.
    View in: PubMed
  14. Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85.
    View in: PubMed
  15. Yuan Y, Fuse S, Ostash B, Sliz P, Kahne D, Walker S. Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem Biol. 2008 Jul 18; 3(7):429-36.
    View in: PubMed
  16. Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 1; 283(31):21310-4.
    View in: PubMed
  17. Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D. Structure and function of an essential component of the outer membrane protein assembly machine. Science. 2007 Aug 17; 317(5840):961-4.
    View in: PubMed
  18. Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5348-53.
    View in: PubMed
  19. Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2103-8.
    View in: PubMed
  20. Azam M, Nardi V, Shakespeare WC, Metcalf CA, Bohacek RS, Wang Y, Sundaramoorthi R, Sliz P, Veach DR, Bornmann WG, Clarkson B, Dalgarno DC, Sawyer TK, Daley GQ. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9244-9.
    View in: PubMed
  21. Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10; 124(5):973-83.
    View in: PubMed
  22. Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005 Dec 1; 438(7068):633-8.
    View in: PubMed
  23. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 2; 432(7017):573-9.
    View in: PubMed
  24. Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004 May 13; 429(6988):193-7.
    View in: PubMed
  25. Jin L, Sliz P, Chen L, Macián F, Rao A, Hogan PG, Harrison SC. An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nat Struct Biol. 2003 Oct; 10(10):807-11.
    View in: PubMed
  26. Sliz P, Harrison SC, Rosenbaum G. How does radiation damage in protein crystals depend on X-ray dose? Structure. 2003 Jan; 11(1):13-9.
    View in: PubMed
  27. Sliz P, Michielin O, Cerottini JC, Luescher I, Romero P, Karplus M, Wiley DC. Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes. J Immunol. 2001 Sep 15; 167(6):3276-84.
    View in: PubMed
  28. Piotr Sliz. Structure, Function and Interactions of Enzyme IIA from the Phosphoenolpyruvate:lactose Phosphotransferase. 2000.
  29. Sliz P, Engelmann R, Hengstenberg W, Pai EF. The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system. Structure. 1997 Jun 15; 5(6):775-88.
    View in: PubMed
  30. Sliz P, Schörter KH, De Vos WM, Pai EF. Crystallization and preliminary structural studies of lactose-specific enzyme IIA from Lactococcus lactis. Acta Crystallogr D Biol Crystallogr. 1996 Nov 1; 52(Pt 6):1199-201.
    View in: PubMed
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