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Stephen Martin Krane, M.D.

TitlePersis, Cyrus and Marlow B. Harrison Distinguished Professor of Clinical Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Medicine, Rheumatology, Bulfich 165
55 Fruit St
Boston MA 02114
Phone617/726-5650
Fax617/726-2872

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Toriseva M, Laato M, Carpén O, Ruohonen ST, Savontaus E, Inada M, Krane SM, Kähäri VM. MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability. PLoS One. 2012; 7(8):e42596.
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  2. Bilezikian JP, Drezner M, Kream B, Stern P, Clemens T, Elderkin A, Siris E, Krane S, Eisman J, Arnold A, Feyen J, Hurley M, Kawaguchi H, Lorenzo J, Peck W, Pilbeam C, Rowe D, Martin TJ, Hock J, DeLuca H, Rodan S, Lukert B, Chen T, Klein-Nulend J. Lawrence G. Raisz November 13, 1925-August 25, 2010. J Bone Miner Res. 2011 May; 26(5):903-11.
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  3. Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2909-14.
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  4. Lecomte J, Louis K, Detry B, Blacher S, Lambert V, Bekaert S, Munaut C, Paupert J, Blaise P, Foidart JM, Rakic JM, Krane SM, Noel A. Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization. Cell Mol Life Sci. 2011 Feb; 68(4):677-86.
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  5. Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM. Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech. 2010 May-Jun; 3(5-6):317-32.
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  6. Krane SM. The importance of proline residues in the structure, stability and susceptibility to proteolytic degradation of collagens. Amino Acids. 2008 Nov; 35(4):703-10.
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  7. Krane SM, Inada M. Matrix metalloproteinases and bone. Bone. 2008 Jul; 43(1):7-18.
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  8. Seton M, Krane SM. Use of zoledronic acid in the treatment of Paget's disease. Ther Clin Risk Manag. 2007 Oct; 3(5):913-8.
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  9. Gutiérrez-Fernández A, Inada M, Balbín M, Fueyo A, Pitiot AS, Astudillo A, Hirose K, Hirata M, Shapiro SD, Noël A, Werb Z, Krane SM, López-Otín C, Puente XS. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J. 2007 Aug; 21(10):2580-91.
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  10. Inoue K, Mikuni-Takagaki Y, Oikawa K, Itoh T, Inada M, Noguchi T, Park JS, Onodera T, Krane SM, Noda M, Itohara S. A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. J Biol Chem. 2006 Nov 3; 281(44):33814-24.
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  11. Krane SM. Is a single infusion of zoledronic acid more effective than oral risedronate for the treatment of patients with Paget's disease? Nat Clin Pract Rheumatol. 2006 Apr; 2(4):186-7.
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  12. Deguchi JO, Aikawa E, Libby P, Vachon JR, Inada M, Krane SM, Whittaker P, Aikawa M. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation. 2005 Oct 25; 112(17):2708-15.
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  13. Kennedy AM, Inada M, Krane SM, Christie PT, Harding B, López-Otín C, Sánchez LM, Pannett AA, Dearlove A, Hartley C, Byrne MH, Reed AA, Nesbit MA, Whyte MP, Thakker RV. MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO). J Clin Invest. 2005 Oct; 115(10):2832-42.
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  14. Krane SM. Identifying genes that regulate bone remodeling as potential therapeutic targets. J Exp Med. 2005 Mar 21; 201(6):841-3.
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  15. Beare AH, Krane SM, Ferguson MW. Variable impairment of wound healing in the heterozygous collagenase-resistant mouse. Wound Repair Regen. 2005 Jan-Feb; 13(1):27-40.
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  16. Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, López-Otín C, Krane SM. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A. 2004 Dec 7; 101(49):17192-7.
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  17. Sabeh F, Ota I, Holmbeck K, Birkedal-Hansen H, Soloway P, Balbin M, Lopez-Otin C, Shapiro S, Inada M, Krane S, Allen E, Chung D, Weiss SJ. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol. 2004 Nov 22; 167(4):769-81.
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  18. Mehrotra M, Krane SM, Walters K, Pilbeam C. Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cells. J Cell Biochem. 2004 Nov 1; 93(4):741-52.
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  19. Jung JC, West-Mays JA, Stramer BM, Byrne MH, Scott S, Mody MK, Sadow PM, Krane SM, Fini ME. Activity and expression of Xenopus laevis matrix metalloproteinases: identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammals. J Cell Physiol. 2004 Oct; 201(1):155-64.
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  20. Fukumoto Y, Deguchi JO, Libby P, Rabkin-Aikawa E, Sakata Y, Chin MT, Hill CC, Lawler PR, Varo N, Schoen FJ, Krane SM, Aikawa M. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation. 2004 Oct 5; 110(14):1953-9.
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  21. Chiusaroli R, Maier A, Knight MC, Byrne M, Calvi LM, Baron R, Krane SM, Schipani E. Collagenase cleavage of type I collagen is essential for both basal and parathyroid hormone (PTH)/PTH-related peptide receptor-induced osteoclast activation and has differential effects on discrete bone compartments. Endocrinology. 2003 Sep; 144(9):4106-16.
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  22. Lindsey ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa M, Libby P, Krane SM, Lee RT. Effect of a cleavage-resistant collagen mutation on left ventricular remodeling. Circ Res. 2003 Aug 8; 93(3):238-45.
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  23. Beare AH, O'Kane S, Krane SM, Ferguson MW. Severely impaired wound healing in the collagenase-resistant mouse. J Invest Dermatol. 2003 Jan; 120(1):153-63.
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  24. Issa R, Zhou X, Trim N, Millward-Sadler H, Krane S, Benyon C, Iredale J. Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration. FASEB J. 2003 Jan; 17(1):47-9.
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  25. Krane SM. Elucidation of the potential roles of matrix metalloproteinases in skeletal biology. Arthritis Res Ther. 2003; 5(1):2-4.
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  26. Inada M, Krane SM. Targeting rheumatoid inflammation and joint destruction in the mouse. J Clin Invest. 2002 Sep; 110(5):611-2.
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  27. Krane SM. Genetic control of bone remodeling--insights from a rare disease. N Engl J Med. 2002 Jul 18; 347(3):210-2.
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  28. Dayer JM, Krane SM. Anti-TNF-alpha therapy for ankylosing spondylitis--a specific or nonspecific treatment? N Engl J Med. 2002 May 2; 346(18):1399-400.
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  29. Krane SM. Petulant cellular acts: destroying the ECM rather than creating it. J Clin Invest. 2001 Jan; 107(1):31-2.
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  30. Zhao W, Byrne MH, Wang Y, Krane SM. Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen. J Clin Invest. 2000 Oct; 106(8):941-9.
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  31. Orcel P, Krane SM. [Secondary osteoporosis and glucocorticoid-induced osteoporosis]. Ann Med Interne (Paris). 2000 Oct; 151(6):497-503.
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  32. Newman MJ, Rodarte JC, Benbatoul KD, Romano SJ, Zhang C, Krane S, Moran EJ, Uyeda RT, Dixon R, Guns ES, Mayer LD. Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer Res. 2000 Jun 1; 60(11):2964-72.
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  33. Orcel P, Tajima H, Murayama Y, Fujita T, Krane SM, Ogata E, Goldring SR, Nishimoto I. Multiple domains interacting with Gs in the porcine calcitonin receptor. Mol Endocrinol. 2000 Jan; 14(1):170-82.
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  34. Zhao W, Byrne MH, Boyce BF, Krane SM. Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. J Clin Invest. 1999 Feb; 103(4):517-24.
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  35. Lanske B, Divieti P, Kovacs CS, Pirro A, Landis WJ, Krane SM, Bringhurst FR, Kronenberg HM. The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology. 1998 Dec; 139(12):5194-204.
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  36. Byers PH, Duvic M, Atkinson M, Robinow M, Smith LT, Krane SM, Greally MT, Ludman M, Matalon R, Pauker S, Quanbeck D, Schwarze U. Ehlers-Danlos syndrome type VIIA and VIIB result from splice-junction mutations or genomic deletions that involve exon 6 in the COL1A1 and COL1A2 genes of type I collagen. Am J Med Genet. 1997 Oct 3; 72(1):94-105.
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  37. Goodman TA, Merkel PA, Perlmutter G, Doyle MK, Krane SM, Polisson RP. Heterotopic ossification in the setting of neuromuscular blockade. Arthritis Rheum. 1997 Sep; 40(9):1619-27.
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  38. Pilcher BK, Dumin JA, Sudbeck BD, Krane SM, Welgus HG, Parks WC. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix. J Cell Biol. 1997 Jun 16; 137(6):1445-57.
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  39. Liu X, Wu H, Byrne M, Krane S, Jaenisch R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997 Mar 4; 94(5):1852-6.
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  40. Seton M, Krane SM. Paget's disease of bone. Curr Ther Endocrinol Metab. 1997; 6:568-72.
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  41. Krane SM, Byrne MH, Lemaître V, Henriet P, Jeffrey JJ, Witter JP, Liu X, Wu H, Jaenisch R, Eeckhout Y. Different collagenase gene products have different roles in degradation of type I collagen. J Biol Chem. 1996 Nov 8; 271(45):28509-15.
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  42. Liu X, Wu H, Byrne M, Jeffrey J, Krane S, Jaenisch R. A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol. 1995 Jul; 130(1):227-37.
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  43. Gorn AH, Rudolph SM, Flannery MR, Morton CC, Weremowicz S, Wang TZ, Krane SM, Goldring SR. Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction. J Clin Invest. 1995 Jun; 95(6):2680-91.
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  44. Krane SM. Is collagenase (matrix metalloproteinase-1) necessary for bone and other connective tissue remodeling? Clin Orthop Relat Res. 1995 Apr; (313):47-53.
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  45. Yamin M, Gorn AH, Flannery MR, Jenkins NA, Gilbert DJ, Copeland NG, Tapp DR, Krane SM, Goldring SR. Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology. 1994 Dec; 135(6):2635-43.
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  46. Krane SM. Clinical importance of metalloproteinases and their inhibitors. Ann N Y Acad Sci. 1994 Sep 6; 732:1-10.
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  47. Goldring SR, Gorn AH, Yamin M, Krane SM, Wang JT. Characterization of the structural and functional properties of cloned calcitonin receptor cDNAs. Horm Metab Res. 1993 Sep; 25(9):477-80.
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  48. Hasty KA, Wu H, Byrne M, Goldring MB, Seyer JM, Jaenisch R, Krane SM, Mainardi CL. Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. Matrix. 1993 May; 13(3):181-6.
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  49. Krane SM. Some molecular mechanisms of glucocorticoid action. Br J Rheumatol. 1993 May; 32 Suppl 2:3-5.
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  50. Gorn AH, Lin HY, Yamin M, Auron PE, Flannery MR, Tapp DR, Manning CA, Lodish HF, Krane SM, Goldring SR. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. J Clin Invest. 1992 Nov; 90(5):1726-35.
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  51. Kang AH, Krane SM, LeRoy EC, Riggs BL, Goldberg VM. Scientific workshop on the biology and pathology of acquired connective tissue diseases. Arthritis Rheum. 1992 Nov; 35(11):1289-95.
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  52. Sellmayer A, Krane SM, Ouellette AJ, Bonventre JV. 1 alpha,25-(OH)2 vitamin D3 enhances expression of the genes encoding Ca(2+)-binding proteins MRP-8 and MRP-14. Am J Physiol. 1992 Jan; 262(1 Pt 1):C235-42.
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  53. Krane SM, Jaenisch R. Site-directed mutagenesis of type I collagen: effect on susceptibility to collagenase. Matrix Suppl. 1992; 1:64-7.
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  54. Conca W, Auron PE, Aoun-Wathne M, Bennett N, Seckinger P, Welgus HG, Goldring SR, Eisenberg SP, Dayer JM, Krane SM, et al. An interleukin 1 beta point mutant demonstrates that jun/fos expression is not sufficient for fibroblast metalloproteinase expression. J Biol Chem. 1991 Sep 5; 266(25):16265-8.
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  55. Skolnik PR, Jahn B, Wang MZ, Rota TR, Hirsch MS, Krane SM. Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol. Proc Natl Acad Sci U S A. 1991 Aug 1; 88(15):6632-6.
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  56. Wu H, Byrne MH, Stacey A, Goldring MB, Birkhead JR, Jaenisch R, Krane SM. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5888-92.
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  57. Goldring SR, Stephenson ML, Downie E, Krane SM, Korn JH. Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts. J Clin Invest. 1990 Mar; 85(3):798-803.
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  58. Krane SM, Conca W, Stephenson ML, Amento EP, Goldring MB. Mechanisms of matrix degradation in rheumatoid arthritis. Ann N Y Acad Sci. 1990; 580:340-54.
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  59. Krane SM, Polla BS, Bonventre JV. 1,25-Dihydroxyvitamin D3 increases the toxicity of hydrogen peroxide: the role of calcium and heat shock. Exp Gerontol. 1990; 25(3-4):239-45.
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  60. Krane SM, Goldring MB. Clinical implications of cartilage metabolism in arthritis. Eur J Rheumatol Inflamm. 1990; 10(1):4-9.
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  61. Conca W, Kaplan PB, Krane SM. Increases in levels of procollagenase messenger RNA in cultured fibroblasts induced by human recombinant interleukin 1 beta or serum follow c-jun expression and are dependent on new protein synthesis. J Clin Invest. 1989 May; 83(5):1753-7.
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  62. Conca W, Kaplan PB, Krane SM. Increases in levels of procollagenase mRNA in human fibroblasts induced by interleukin-1, tumor necrosis factor-alpha, or serum follow c-jun expression and are dependent on new protein synthesis. Trans Assoc Am Physicians. 1989; 102:195-203.
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  63. Goldring MB, Birkhead J, Sandell LJ, Kimura T, Krane SM. Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest. 1988 Dec; 82(6):2026-37.
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  64. Polla BS, Bonventre JV, Krane SM. 1,25-Dihydroxyvitamin D3 increases the toxicity of hydrogen peroxide in the human monocytic line U937: the role of calcium and heat shock. J Cell Biol. 1988 Jul; 107(1):373-80.
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  65. Stamenkovic I, Stegagno M, Wright KA, Krane SM, Amento EP, Colvin RB, Duquesnoy RJ, Kurnick JT. T lymphocyte infiltrates in inflammatory synovia are oligoclonal. Transplant Proc. 1988 Apr; 20(2):315-9.
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  66. Simon LS, Slovik DM, Neer RM, Krane SM. Changes in serum levels of type I and III procollagen extension peptides during infusion of human parathyroid hormone fragment (1-34). J Bone Miner Res. 1988 Apr; 3(2):241-6.
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  67. Stamenkovic I, Stegagno M, Wright KA, Krane SM, Amento EP, Colvin RB, Duquesnoy RJ, Kurnick JT. Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1179-83.
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  68. Krane SM, Goldring MB, Goldring SR. Cytokines. Ciba Found Symp. 1988; 136:239-56.
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  69. Stamenkovic I, Stegagno M, Krane SM, Kurnick JT. T lymphocytes in synovia of patients with rheumatoid arthritis. Springer Semin Immunopathol. 1988; 10(2-3):169-80.
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  70. Krane SM, Goldring MB. Potential role for interleukin-1 in fibrosis associated with chronic ambulatory peritoneal dialysis. Blood Purif. 1988; 6(3):173-7.
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  71. Goldring MB, Krane SM. Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells. J Biol Chem. 1987 Dec 5; 262(34):16724-9.
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  72. Parfitt AM, Simon LS, Villanueva AR, Krane SM. Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with Iliac bone formation rates and comparison with total alkaline phosphatase. J Bone Miner Res. 1987 Oct; 2(5):427-36.
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  73. Polla BS, Healy AM, Byrne M, Krane SM. 1,25-Dihydroxyvitamin D3 induces collagen binding to the human monocyte line U937. J Clin Invest. 1987 Oct; 80(4):962-9.
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  74. Polla BS, Healy AM, Wojno WC, Krane SM. Hormone 1 alpha,25-dihydroxyvitamin D3 modulates heat shock response in monocytes. Am J Physiol. 1987 Jun; 252(6 Pt 1):C640-9.
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  75. Stephenson ML, Goldring MB, Birkhead JR, Krane SM, Rahmsdorf HJ, Angel P. Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1 beta or phorbol ester. Biochem Biophys Res Commun. 1987 Apr 29; 144(2):583-90.
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  76. Krane SM, Simon LS. Metabolic consequences of bone turnover in Paget's disease of bone. Clin Orthop Relat Res. 1987 Apr; (217):26-36.
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  77. Goldring MB, Sandell LJ, Stephenson ML, Krane SM. Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes. J Biol Chem. 1986 Jul 5; 261(19):9049-55.
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  78. Upchurch KS, Parker LM, Scully RE, Krane SM. Differential cyclic AMP responses to calcitonin among human ovarian carcinoma cell lines: a calcitonin-responsive line derived from a rare tumor type. J Bone Miner Res. 1986 Jun; 1(3):299-304.
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  79. Goldring SR, Amento EP, Roelke MS, Krane SM. The adenosine 3':5'-cyclic monophosphate response to prostaglandin E2 is altered in U937 cells in association with maturational events induced by activated T lymphocytes and 1,25-dihydroxyvitamin D3. J Immunol. 1986 May 1; 136(9):3461-6.
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  80. Polla BS, Healy AM, Amento EP, Krane SM. 1,25-Dihydroxyvitamin D3 maintains adherence of human monocytes and protects them from thermal injury. J Clin Invest. 1986 Apr; 77(4):1332-9.
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  81. Bhalla AK, Amento EP, Krane SM. Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production. Cell Immunol. 1986 Apr 1; 98(2):311-22.
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  82. Goldring SR, Schiller AL, Mankin HJ, Dayer JM, Krane SM. Characterization of cells from human giant cell tumors of bone. Clin Orthop Relat Res. 1986 Mar; (204):59-75.
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  83. Krane SM, Simon LS. Rheumatoid arthritis: clinical features and pathogenetic mechanisms. Med Clin North Am. 1986 Mar; 70(2):263-84.
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  84. McCroskery PA, Arai S, Amento EP, Krane SM. Stimulation of procollagenase synthesis in human rheumatoid synovial fibroblasts by mononuclear cell factor/interleukin 1. FEBS Lett. 1985 Oct 21; 191(1):7-12.
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  85. Amento EP, Bhan AK, McCullagh KG, Krane SM. Influences of gamma interferon on synovial fibroblast-like cells. Ia induction and inhibition of collagen synthesis. J Clin Invest. 1985 Aug; 76(2):837-48.
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  86. Krane SM, Dayer JM, Simon LS, Byrne MS. Mononuclear cell-conditioned medium containing mononuclear cell factor (MCF), homologous with interleukin 1, stimulates collagen and fibronectin synthesis by adherent rheumatoid synovial cells: effects of prostaglandin E2 and indomethacin. Coll Relat Res. 1985 Mar; 5(2):99-117.
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  87. Stephenson ML, Krane SM, Amento EP, McCroskery PA, Byrne M. Immune interferon inhibits collagen synthesis by rheumatoid synovial cells associated with decreased levels of the procollagen mRNAs. FEBS Lett. 1985 Jan 21; 180(1):43-50.
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  88. Krane SM. The turnover and degradation of collagen. Ciba Found Symp. 1985; 114:97-110.
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  89. Amento EP, Kurnick JT, Krane SM. Interleukin 1 production by the human monocyte cell line U937 requires a lymphokine induction signal distinct from interleukin 2 or interferons. J Immunol. 1985 Jan; 134(1):350-7.
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  90. Harris ED, Welgus HG, Krane SM. Regulation of the mammalian collagenases. Coll Relat Res. 1984 Dec; 4(6):493-512.
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  91. Krane SM. Cellular interactions in the inflammatory synovium. Ryumachi. 1984 Oct; 24(5):389-96.
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  92. Dayer JM, Roelke MS, Krane SM. Effects of prostaglandin E2, indomethacin, trifluoperazine and drugs affecting the cytoskeleton on collagenase production by cultured adherent rheumatoid synovial cells. Biochem Pharmacol. 1984 Sep 15; 33(18):2893-9.
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  93. Crisp AJ, Chapman CM, Kirkham SE, Schiller AL, Krane SM. Articular mastocytosis in rheumatoid arthritis. Arthritis Rheum. 1984 Aug; 27(8):845-51.
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  94. Crisp AJ, Roelke MS, Goldring SR, Krane SM. Heparin modulates intracellular cyclic AMP in human trabecular bone cells and adherent rheumatoid synovial cells. Ann Rheum Dis. 1984 Aug; 43(4):628-34.
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  95. Goldring SR, Dayer JM, Krane SM. Rheumatoid synovial cell hormone responses modulated by cell-cell interactions. Inflammation. 1984 Mar; 8(1):107-21.
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  96. Amento EP, Bhalla AK, Kurnick JT, Kradin RL, Clemens TL, Holick SA, Holick MF, Krane SM. 1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor. J Clin Invest. 1984 Mar; 73(3):731-9.
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  97. Goldring SR, Tyler GA, Krane SM, Potts JT, Rosenblatt M. Photoaffinity labeling of parathyroid hormone receptors: comparison of receptors across species and target tissues and after desensitization to hormone. Biochemistry. 1984 Jan 31; 23(3):498-502.
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  98. Krane SM. Collagen degradation. Prog Clin Biol Res. 1984; 154:89-102.
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  99. Simon LS, Krane SM, Wortman PD, Krane IM, Kovitz KL. Serum levels of type I and III procollagen fragments in Paget's disease of bone. J Clin Endocrinol Metab. 1984 Jan; 58(1):110-20.
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  100. Peck W, Gennari C, Raisz L, Meunier P, Ritz E, Krane S, Nuki G, Avioli LV. Corticosteroids and bone. Calcif Tissue Int. 1984 Jan; 36(1):4-7.
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  101. Krane SM, Amento EP. Glucocorticoids and collagen diseases. Adv Exp Med Biol. 1984; 171:61-71.
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  102. Bhalla AK, Amento EP, Clemens TL, Holick MF, Krane SM. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab. 1983 Dec; 57(6):1308-10.
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  103. Krane SM, Amento EP. Cellular interactions and control of collagenase secretion in the synovium. J Rheumatol Suppl. 1983 Dec; 11:7-12.
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  104. Moscicki RA, Amento EP, Krane SM, Kurnick JT, Colvin RB. Modulation of surface antigens of a human monocyte cell line, U937, during incubation with T lymphocyte-conditioned medium: detection of T4 antigen and its presence on normal blood monocytes. J Immunol. 1983 Aug; 131(2):743-8.
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  105. Upchurch KS, Simon LS, Schiller AL, Rosenthal DI, Campion EW, Krane SM. Giant cell reparative granuloma of Paget's disease of bone: a unique clinical entity. Ann Intern Med. 1983 Jan; 98(1):35-40.
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  106. Nardella FA, Dayer JM, Roelke M, Krane SM, Mannik M. Self-associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and mononuclear cell factor that stimulates collagenase and prostaglandin production by synovial cells. Rheumatol Int. 1983; 3(4):183-6.
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  107. Krane SM. Paget's disease. Henry Ford Hosp Med J. 1983; 31(4):227-8.
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  108. Baker DG, Dayer JM, Roelke M, Schumacher HR, Krane SM. Rheumatoid synovial cell morphologic changes induced by a mononuclear cell factor in culture. Arthritis Rheum. 1983 Jan; 26(1):8-14.
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  109. Dayer JM, Trentham DE, Krane SM. Collagens act as ligands to stimulate human monocytes to produce mononuclear cell factor (MCF) and prostaglandins (PGE2). Coll Relat Res. 1982 Nov; 2(6):523-40.
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  110. Amento EP, Kurnick JT, Epstein A, Krane SM. Modulation of synovial cell products by a factor from a human cell line: T lymphocyte induction of a mononuclear cell factor. Proc Natl Acad Sci U S A. 1982 Sep; 79(17):5307-11.
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  111. Krane SM. Collagenases and collagen degradation. J Invest Dermatol. 1982 Jul; 79 Suppl 1:83s-86s.
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  112. Krane SM. Etidronate disodium in the treatment of Paget's disease of bone. Ann Intern Med. 1982 May; 96(5):619-25.
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  113. Krane S. Collagen degradation. Connect Tissue Res. 1982; 10(1):51-9.
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  114. Dayer JM, Vassalli JD, Bobbitt JL, Hull RN, Reich E, Krane SM. Calcitonin stimulates plasminogen activator in porcine renal tubular cells: LLC-PK1. J Cell Biol. 1981 Oct; 91(1):195-200.
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  115. Krane SM. Heberden Oration 1980: aspects of the cell biology of the rheumatoid synovial lesion. Ann Rheum Dis. 1981 Oct; 40(5):433-48.
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  116. Sims NM, Kelley KL, Dayer JM, Krane SM. Calcitonin stimulates amino acid incorporation into plasminogen activator by cultured renal tubular cells. FEBS Lett. 1981 Sep 28; 132(2):174-8.
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  117. Mizel SB, Dayer JM, Krane SM, Mergenhagen SE. Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1). Proc Natl Acad Sci U S A. 1981 Apr; 78(4):2474-7.
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  118. Goldring SR, Krane SM. Metabolic bone disease: osteoporosis and osteomalacia. Dis Mon. 1981 Apr; 27(7):1-103.
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  119. Dayer JM, Stephenson ML, Schmidt E, Karge W, Krane SM. Purification of a factor from human blood monocyte-macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rheumatoid synovial tissues. FEBS Lett. 1981 Feb 23; 124(2):253.
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  120. Héron JF, Dayer JM, Goldring SR, Krane SM. Factors modulating the response of a porcine renal tubular cell line to calcitonin and antidiuretic hormone. Calcif Tissue Int. 1981; 33(1):41-50.
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  121. Krane SM. Skeletal metabolism in Paget's disease of bone. Arthritis Rheum. 1980 Oct; 23(10):1087-94.
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  122. Krane SM. Understanding genetic disorders of collagen. N Engl J Med. 1980 Jul 10; 303(2):101-2.
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  123. Dayer JM, Passwell JH, Schneeberger EE, Krane SM. Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments. J Immunol. 1980 Apr; 124(4):1712-20.
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  124. Goldring SR, Krane SM. Cation effects on phosphate homeostasis in hypophosphatemic subjects. Adv Exp Med Biol. 1980; 128:361-8.
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  125. Dayer JM, Trentham DE, David JR, Krane SM. Collagens stimulate the production of mononuclear cell factor (MCF) and prostaglandins (PGE2) by human monocytes. Trans Assoc Am Physicians. 1980; 93:326-35.
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  126. Dayer JM, Bréard J, Chess L, Krane SM. Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells. J Clin Invest. 1979 Nov; 64(5):1386-92.
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  127. Dayer JM, Goldring SR, Robinson DR, Krane SM. Collagenase and prostaglandin in connective tissue destruction: cell-cell and humoral interactions. Bull Schweiz Akad Med Wiss. 1979 Sep; 35(4-6):329-43.
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  128. Quinn RS, Krane SM. Collagen synthesis by cultured skin fibroblasts from siblings with hydroxylysine-deficient collagen. Biochim Biophys Acta. 1979 Jul 18; 585(4):589-98.
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  129. Goldring SR, Mahaffey JE, Rosenblatt M, Dayer JM, Potts JT, Krane SM. Parathyroid hormone inhibitors: comparison of biological activity in bone- and skin-derived tissue. J Clin Endocrinol Metab. 1979 Apr; 48(4):655-9.
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  130. Robinson DR, Dayer JM, Krane SM. Prostaglandins and their regulation in rheumatoid inflammation. Ann N Y Acad Sci. 1979; 332:279-94.
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  131. Goldring SR, Dayer JM, Krane SM. Regulation of hormone-induced cyclic AMP response to parathyroid hormone and prostaglandin E2 in cells cultured from human giant cell tumors of bone. Calcif Tissue Int. 1979; 29(3):193-200.
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  132. Goldring SR, Dayer JM, Ausiello DA, Krane SM. A cell strain cultured from porcine kidney increases cyclic AMP content upon exposure to calcitonin or vasopressin. Biochem Biophys Res Commun. 1978 Jul 28; 83(2):434-40.
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  133. Goldring SR, Dayer JM, Russell RG, Mankin HJ, Krane SM. Response to hormones of cells cultured from human giant cell tumors of bone. J Clin Endocrinol Metab. 1978 Mar; 46(3):425-33.
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  134. Krane SM, Kantrowitz FG, Byrne M, Pinnell SR, Singer FR. Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation. J Clin Invest. 1977 May; 59(5):819-27.
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  135. Dayer JM, Robinson DR, Krane SM. Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear Cells. J Exp Med. 1977 May 1; 145(5):1399-1404.
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  136. Goldring SR, Dayer JM, Russell RG, Mankin HJ, Krane SM. Cells cultured from human giant cell tumors of bone respond to parathyroid hormone. Calcif Tissue Res. 1977 May; 22 Suppl:269-74.
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  137. Dayer JM, Graham R, Russell G, Krane SM. Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor. Science. 1977 Jan 14; 195(4274):181-3.
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  138. Krane SM. Paget's disease of bone. Clin Orthop Relat Res. 1977; (127):24-36.
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  139. Quinn RS, Rosenblatt M, Krane SM. Proteolytic activity in human skin fibroblasts harvested with trypsin and its effect on measurements of collagen hydroxylase activities. Biochem Biophys Res Commun. 1976 Jul 12; 71(1):300-6.
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  140. Dayer JM, Krane SM, Russell RG, Robinson DR. Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. Proc Natl Acad Sci U S A. 1976 Mar; 73(3):945-9.
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  141. Quinn RS, Krane SM. Abnormal properties of collagen lysyl hydroxylase from skin fibroblasts of siblings with hydroxylysine-deficient collagen. J Clin Invest. 1976 Jan; 57(1):83-93.
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  142. Krane SM. Collagenase production by human synovial tissues. Ann N Y Acad Sci. 1975 Jun 13; 256:289-303.
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  143. Harris ED, Krane SM. Collagenases (third of three parts). N Engl J Med. 1974 Sep 26; 291(13):652-61.
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  144. Harris ED, Krane SM. Collagenases (second of three parts). N Engl J Med. 1974 Sep 19; 291(12):605-9.
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  145. Harris ED, Krane SM. Collagenases (first of three parts). N Engl J Med. 1974 Sep 12; 291(11):557-63.
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  146. Franck WA, Bress NM, Singer FR, Krane SM. Rheumatic manifestations of Paget's disease of bone. Am J Med. 1974 May; 56(5):592-603.
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  147. Krane SM. IV. Joint erosion in rheumatoid arthritis. Arthritis Rheum. 1974 May-Jun; 17(3):306-12.
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  148. Harris ED, Krane SM. Cartilage collagen: substrate in soluble and fibrillar form for rheumatoid collagenase. Trans Assoc Am Physicians. 1973; 86:82-94.
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  149. Krane SM, Harris ED, Singer FR, Potts JT. Acute effects of calcitonin on bone formation in man. Metabolism. 1973 Jan; 22(1):51-8.
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  150. Krane SM, Pinnell SR, Erbe RW. Lysyl-protocollagen hydroxylase deficiency in fibroblasts from siblings with hydroxylysine-deficient collagen. Proc Natl Acad Sci U S A. 1972 Oct; 69(10):2899-903.
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  151. Singer FR, Aldred JP, Neer RM, Krane SM, Potts JT, Bloch KJ. An evaluation of antibodies and clinical resistance to salmon calcitonin. J Clin Invest. 1972 Sep; 51(9):2331-8.
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  152. Harris ED, Parker HG, Radin EL, Krane SM. Effects of proteolytic enzymes on structural and mechanical properties of cartilage. Arthritis Rheum. 1972 Sep-Oct; 15(5):497-503.
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  153. Pinnell SR, Krane SM, Kenzora JE, Glimcher MJ. A heritable disorder of connective tissue. Hydroxylysine-deficient collagen disease. N Engl J Med. 1972 May 11; 286(19):1013-20.
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  154. Harris ED, Krane SM. An endopeptidase from rheumatoid synovial tissue culture. Biochim Biophys Acta. 1972 Feb 28; 258(2):566-76.
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  155. Krane SM. Action of salicylates. N Engl J Med. 1972 Feb 10; 286(6):317-8.
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  156. Harris ED, Krane SM. Effects of colchicine on collagenase in cultures of rheumatoid synovium. Arthritis Rheum. 1971 Nov-Dec; 14(6):669-84.
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  157. Krane SM. Serum phosphorus in uremia. N Engl J Med. 1970 Jul 30; 283(5):264.
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  158. Krane SM, Muñoz AJ, Harris ED. Urinary polypeptides related to collagen synthesis. J Clin Invest. 1970 Apr; 49(4):716-29.
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  159. Harris ED, Evanson JM, DiBona DR, Krane SM. Collagenase and rheumatoid arthritis. Arthritis Rheum. 1970 Jan-Feb; 13(1):83-94.
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  160. Harris ED, DiBona DR, Krane SM. A mechanism for cartilage destruction in rheumatoid arthritis. Trans Assoc Am Physicians. 1970; 83:267-76.
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  161. Harris ED, DiBona DR, Krane SM. Collagenases in human synovial fluid. J Clin Invest. 1969 Nov; 48(11):2104-13.
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  162. Harris ED, Cohen GL, Krane SM. Synovial collagenase: its presence in culture from joint disease of diverse etiology. Arthritis Rheum. 1969 Apr; 12(2):92-102.
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  163. Evanson JM, Jeffrey JJ, Krane SM. Studies on collagenase from rheumatoid synovium in tissue culture. J Clin Invest. 1968 Dec; 47(12):2639-51.
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  164. Christian CL, Butler VP, Hamerman D, Krane SM, Larson CB, Malawista SE, Mikkelsen WM, Pearson CM, Symthe HA, Taranta A, Tomasi TB, Ward LE, Weinberger HJ. Eighteenth rheumatism review. Review of American and English literature for the years 1965 and 1966. Arthritis Rheum. 1968 Jun; 11(3):Suppl:523-732.
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  165. Evanson JM, Jeffrey JJ, Krane SM. Human collagenase: identification and characterization of an enzyme from rheumatoid synovium in culture. Science. 1967 Oct 27; 158(3800):499-502.
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  166. Nagant de Deuxchaisnes C, Krane SM. The treatment of adult phosphate diabetes and Fanconi syndrome with neutral sodium phosphate. Am J Med. 1967 Oct; 43(4):508-43.
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  167. Krane SM, Muñoz AJ, Harris ED. Collagen-like fragments: excretion in urine of patients with Paget's disease of bone. Science. 1967 Aug 11; 157(3789):713-6.
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  168. KUNIN AS, KRANE SM. INHIBITION BY PUROMYCIN OF THE CALCIUM-MOBILIZING ACTIVITY OF PARATHYROID EXTRACT. Endocrinology. 1965 Feb; 76:343-4.
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  169. NAGANTDEDEUXCHAISNES C, KRANE SM. PAGET'S DISEASE OF BONE: CLINICAL AND METABOLIC OBSERVATIONS. Medicine (Baltimore). 1964 May; 43:233-66.
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  170. DE DEUXCHAISNES CN, KRANE SM. PAGET'S DISEASE OF BONE: CLINICAL AND METABOLIC OBSERVATIONS. Medicine (Baltimore). 1964 May; 43:233-66.
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  171. KRANE SM. Current concepts in therapy. Renal lithiasis. N Engl J Med. 1962 Nov 8; 267:977 concl.
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  172. KRANE SM. Renal lithiasis. N Engl J Med. 1962 Oct 25; 267:875-7 contd.
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  173. ISSELBACHER KJ, KRANE SM. Studies on the mechanism of the inhibition of galactose oxidation by ethanol. J Biol Chem. 1961 Sep; 236:2394-8.
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  174. KRANE SM. Parathyroid damage in man: mechanism of effect on serum levels of calcium and phosphorus. J Clin Endocrinol Metab. 1957 Mar; 17(3):386-9.
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  175. KRANE SM, BROWNELL GL, STANBURY JB, CORRIGAN H. The effect of thyroid disease on calcium metabolism in man. J Clin Invest. 1956 Aug; 35(8):874-87.
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