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Kirk R. Daffner, M.D.

TitleJ. David and Virginia Wimberly Professor of Neurology
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressBrigham & Women's Hospital
Div of Cog. & Behav. Neurology
221 Longwood Ave
Boston MA 02115
Phone617/732-8060
Fax617/738-9122

 Biography 
 awards and honors
1974 - Harvard College Honorary National Scholar
1978 - Magna Cum Laude
1978 - Phi Beta Kappa
1980 - Harvard Graduate National Scholard

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Daffner KR, Alperin BR, Mott KK, Holcomb PJ. Age-related differences in the automatic processing of single letters: implications for selective attention. Neuroreport. 2014 Jan 22; 25(2):77-82.
    View in: PubMed
  2. Alperin BR, Haring AE, Zhuravleva TY, Holcomb PJ, Rentz DM, Daffner KR. The Dissociation between Early and Late Selection in Older Adults. J Cogn Neurosci. 2013 Dec; 25(12):2189-206.
    View in: PubMed
  3. Haring AE, Zhuravleva TY, Alperin BR, Rentz DM, Holcomb PJ, Daffner KR. Age-related differences in enhancement and suppression of neural activity underlying selective attention in matched young and old adults. Brain Res. 2013 Mar 7; 1499:69-79.
    View in: PubMed
  4. Perez DL, Dickerson BC, McGinnis SM, Sapolsky D, Johnson K, Searl M, Daffner KR. You don't say: dynamic aphasia, another variant of primary progressive aphasia? J Alzheimers Dis. 2013 Jan 1; 34(1):139-44.
    View in: PubMed
  5. Daffner KR, Haring AE, Alperin BR, Zhuravleva TY, Mott KK, Holcomb PJ. The impact of visual acuity on age-related differences in neural markers of early visual processing. Neuroimage. 2013 Feb 15; 67:127-36.
    View in: PubMed
  6. Daffner KR, Tarbi EC, Haring AE, Zhuravleva TY, Sun X, Rentz DM, Holcomb PJ. The influence of executive capacity on selective attention and subsequent processing. Front Hum Neurosci. 2012; 6:167.
    View in: PubMed
  7. Perez DL, Barsky AJ, Daffner K, Silbersweig DA. Motor and somatosensory conversion disorder: a functional unawareness syndrome? J Neuropsychiatry Clin Neurosci. 2012 Mar 1; 24(2):141-51.
    View in: PubMed
  8. Daffner KR, Zhuravleva TY, Sun X, Tarbi EC, Haring AE, Rentz DM, Holcomb PJ. Does modulation of selective attention to features reflect enhancement or suppression of neural activity? Biol Psychol. 2012 Feb; 89(2):398-407.
    View in: PubMed
  9. Perez DL, Larvie M, Acar D, Daffner K. Teaching NeuroImages: apathetic variant of frontotemporal dementia. Neurology. 2011 Nov 15; 77(20):e117.
    View in: PubMed
  10. Tarbi EC, Sun X, Holcomb PJ, Daffner KR. Surprise? Early visual novelty processing is not modulated by attention. Psychophysiology. 2011 May; 48(5):624-32.
    View in: PubMed
  11. Daffner KR, Sun X, Tarbi EC, Rentz DM, Holcomb PJ, Riis JL. Does compensatory neural activity survive old-old age? Neuroimage. 2011 Jan 1; 54(1):427-38.
    View in: PubMed
  12. Daffner KR, Chong H, Sun X, Tarbi EC, Riis JL, McGinnis SM, Holcomb PJ. Mechanisms underlying age- and performance-related differences in working memory. J Cogn Neurosci. 2011 Jun; 23(6):1298-314.
    View in: PubMed
  13. Chemali Z, Withall A, Daffner KR. The plight of caring for young patients with frontotemporal dementia. Am J Alzheimers Dis Other Demen. 2010 Mar; 25(2):109-15.
    View in: PubMed
  14. Daffner KR. Promoting successful cognitive aging: a comprehensive review. J Alzheimers Dis. 2010; 19(4):1101-22.
    View in: PubMed
  15. Riis JL, Chong H, McGinnnis S, Tarbi E, Sun X, Holcomb PJ, Rentz DM, Daffner KR. Age-related changes in early novelty processing as measured by ERPs. Biol Psychol. 2009 Sep; 82(1):33-44.
    View in: PubMed
  16. Wolk DA, Sen NM, Chong H, Riis JL, McGinnis SM, Holcomb PJ, Daffner KR. ERP correlates of item recognition memory: effects of age and performance. Brain Res. 2009 Jan 23; 1250:218-31.
    View in: PubMed
  17. Daffner KR, Sherman JC, Gonzalez RG, Hasserjian RP. Case records of the Massachusetts General Hospital. Case 35-2008. A 65-year-old man with confusion and memory loss. N Engl J Med. 2008 Nov 13; 359(20):2155-64.
    View in: PubMed
  18. Daffner KR, Searl MM. The dysexecutive syndromes. Handb Clin Neurol. 2008; 88:249-67.
    View in: PubMed
  19. Chong H, Riis JL, McGinnis SM, Williams DM, Holcomb PJ, Daffner KR. To ignore or explore: top-down modulation of novelty processing. J Cogn Neurosci. 2008 Jan; 20(1):120-34.
    View in: PubMed
  20. Rentz DM, Huh TJ, Sardinha LM, Moran EK, Becker JA, Daffner KR, Sperling RA, Johnson KA. Intelligence quotient-adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion. J Int Neuropsychol Soc. 2007 Sep; 13(5):821-31.
    View in: PubMed
  21. Riis JL, Chong H, Ryan KK, Wolk DA, Rentz DM, Holcomb PJ, Daffner KR. Compensatory neural activity distinguishes different patterns of normal cognitive aging. Neuroimage. 2008 Jan 1; 39(1):441-54.
    View in: PubMed
  22. Scharf JM, Daffner KR. NSAIDs in the prevention of dementia: a Cache-22? Neurology. 2007 Jul 17; 69(3):235-6.
    View in: PubMed
  23. Daffner KR, Chong H, Riis J, Rentz DM, Wolk DA, Budson AE, Holcomb PJ. Cognitive status impacts age-related changes in attention to novel and target events in normal adults. Neuropsychology. 2007 May; 21(3):291-300.
    View in: PubMed
  24. Wolk DA, Schacter DL, Lygizos M, Sen NM, Chong H, Holcomb PJ, Daffner KR, Budson AE. ERP correlates of Remember/Know decisions: association with the late posterior negativity. Biol Psychol. 2007 May; 75(2):131-5.
    View in: PubMed
  25. Rentz DM, Sardinha LM, Huh TJ, Searl MM, Daffner KR, Sperling RA. IQ-based norms for highly intelligent adults. Clin Neuropsychol. 2006 Dec; 20(4):637-48.
    View in: PubMed
  26. Daffner KR, Ryan KK, Williams DM, Budson AE, Rentz DM, Wolk DA, Holcomb PJ. Increased responsiveness to novelty is associated with successful cognitive aging. J Cogn Neurosci. 2006 Oct; 18(10):1759-73.
    View in: PubMed
  27. Wolk DA, Schacter DL, Lygizos M, Sen NM, Holcomb PJ, Daffner KR, Budson AE. ERP correlates of recognition memory: effects of retention interval and false alarms. Brain Res. 2006 Jun 22; 1096(1):148-62.
    View in: PubMed
  28. Frenck-Mestre C, Meunier C, Espesser R, Daffner K, Holcomb P. Perceiving nonnative vowels: the effect of context on perception as evidenced by event-related brain potentials. J Speech Lang Hear Res. 2005 Dec; 48(6):1496-510.
    View in: PubMed
  29. Daffner KR, Ryan KK, Williams DM, Budson AE, Rentz DM, Wolk DA, Holcomb PJ. Age-related differences in attention to novelty among cognitively high performing adults. Biol Psychol. 2006 Apr; 72(1):67-77.
    View in: PubMed
  30. Budson AE, Droller DB, Dodson CS, Schacter DL, Rugg MD, Holcomb PJ, Daffner KR. Electrophysiological dissociation of picture versus word encoding: the distinctiveness heuristic as a retrieval orientation. J Cogn Neurosci. 2005 Aug; 17(8):1181-93.
    View in: PubMed
  31. Budson AE, Dodson CS, Daffner KR, Schacter DL. Metacognition and false recognition in Alzheimer's disease: further exploration of the distinctiveness heuristic. Neuropsychology. 2005 Mar; 19(2):253-8.
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  32. Wolk DA, Schacter DL, Berman AR, Holcomb PJ, Daffner KR, Budson AE. Patients with mild Alzheimer's disease attribute conceptual fluency to prior experience. Neuropsychologia. 2005; 43(11):1662-72.
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  33. Budson AE, Dodson CS, Vatner JM, Daffner KR, Black PM, Schacter DL. Metacognition and false recognition in patients with frontal lobe lesions: the distinctiveness heuristic. Neuropsychologia. 2005; 43(6):860-71.
    View in: PubMed
  34. Daffner KR, Ryan KK, Williams DM, Budson AE, Rentz DM, Scinto LF, Holcomb PJ. Age-related differences in novelty and target processing among cognitively high performing adults. Neurobiol Aging. 2005 Oct; 26(9):1283-95.
    View in: PubMed
  35. Wolk DA, Schacter DL, Berman AR, Holcomb PJ, Daffner KR, Budson AE. An electrophysiological investigation of the relationship between conceptual fluency and familiarity. Neurosci Lett. 2004 Oct 14; 369(2):150-5.
    View in: PubMed
  36. Gallo DA, Sullivan AL, Daffner KR, Schacter DL, Budson AE. Associative recognition in Alzheimer's disease: evidence for impaired recall-to-reject. Neuropsychology. 2004 Jul; 18(3):556-63.
    View in: PubMed
  37. Budson AE, Simons JS, Sullivan AL, Beier JS, Solomon PR, Scinto LF, Daffner KR, Schacter DL. Memory and emotions for the september 11, 2001, terrorist attacks in patients with Alzheimer's disease, patients with mild cognitive impairment, and healthy older adults. Neuropsychology. 2004 Apr; 18(2):315-27.
    View in: PubMed
  38. Rentz DM, Huh TJ, Faust RR, Budson AE, Scinto LF, Sperling RA, Daffner KR. Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals. Neuropsychology. 2004 Jan; 18(1):38-49.
    View in: PubMed
  39. Goldmann RE, Sullivan AL, Droller DB, Rugg MD, Curran T, Holcomb PJ, Schacter DL, Daffner KR, Budson AE. Late frontal brain potentials distinguish true and false recognition. Neuroreport. 2003 Sep 15; 14(13):1717-20.
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  40. Budson AE, Sullivan AL, Daffner KR, Schacter DL. Semantic versus phonological false recognition in aging and Alzheimer's disease. Brain Cogn. 2003 Apr; 51(3):251-61.
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  41. Budson AE, Michalska KJ, Sullivan AL, Rentz DM, Daffner KR, Schacter DL. False recognition in Alzheimer disease: evidence from categorized pictures. Cogn Behav Neurol. 2003 Mar; 16(1):16-27.
    View in: PubMed
  42. Daffner KR, Scinto LF, Weitzman AM, Faust R, Rentz DM, Budson AE, Holcomb PJ. Frontal and parietal components of a cerebral network mediating voluntary attention to novel events. J Cogn Neurosci. 2003 Feb 15; 15(2):294-313.
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  43. Budson AE, Sullivan AL, Mayer E, Daffner KR, Black PM, Schacter DL. Suppression of false recognition in Alzheimer's disease and in patients with frontal lobe lesions. Brain. 2002 Dec; 125(Pt 12):2750-65.
    View in: PubMed
  44. Budson AE, Sitarski J, Daffner KR, Schacter DL. False recognition of pictures versus words in Alzheimer's disease: the distinctiveness heuristic. Neuropsychology. 2002 Apr; 16(2):163-73.
    View in: PubMed
  45. Budson AE, Michalska KJ, Rentz DM, Joubert CC, Daffner KR, Schacter DL, Sperling RA. Use of a false recognition paradigm in an Alzheimer's disease clinical trial: a pilot study. Am J Alzheimers Dis Other Demen. 2002 Mar-Apr; 17(2):93-100.
    View in: PubMed
  46. Scinto LF, Frosch M, Wu CK, Daffner KR, Gedi N, Geula C. Selective cell loss in Edinger-Westphal in asymptomatic elders and Alzheimer's patients. Neurobiol Aging. 2001 Sep-Oct; 22(5):729-36.
    View in: PubMed
  47. Daffner KR, Rentz DM, Scinto LF, Faust R, Budson AE, Holcomb PJ. Pathophysiology underlying diminished attention to novel events in patients with early AD. Neurology. 2001 May 22; 56(10):1377-83.
    View in: PubMed
  48. Budson AE, Desikan R, Daffner KR, Schacter DL. Perceptual false recognition in Alzheimer's disease. Neuropsychology. 2001 Apr; 15(2):230-43.
    View in: PubMed
  49. Daffner KR, Scinto LFM, Faust R, Rentz D, Budson AE, Holcomb P. Components of a cerebral network mediating voluntary attention to novel events. Neurology. 2001; 56:A313.
  50. Rentz DM, Michalska K, Faust RR, Budson AE, Scinto LFM, Sperling RA, Daffner KR. Predicting mild cognitive impairment in high-functioning elders. Neurology. 2001; 56 (Supplement 3):A71.
  51. Sperling RA, Guttmann CR, Hohol MJ, Warfield SK, Jakab M, Parente M, Diamond EL, Daffner KR, Olek MJ, Orav EJ, Kikinis R, Jolesz FA, Weiner HL. Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch Neurol. 2001 Jan; 58(1):115-21.
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  52. Daffner KR, Mesulam MM, Scinto LF, Calvo V, Faust R, Holcomb PJ. An electrophysiological index of stimulus unfamiliarity. Psychophysiology. 2000 Nov; 37(6):737-47.
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  53. Daffner KR, Mesulam MM, Scinto LF, Acar D, Calvo V, Faust R, Chabrerie A, Kennedy B, Holcomb P. The central role of the prefrontal cortex in directing attention to novel events. Brain. 2000 May; 123 ( Pt 5):927-39.
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  54. Daffner KR, Scinto LF, Calvo V, Faust R, Mesulam MM, West WC, Holcomb PJ. The influence of stimulus deviance on electrophysiologic and behavioral responses to novel events. J Cogn Neurosci. 2000 May; 12(3):393-406.
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  55. Budson AE, Daffner KR, Desikan R, Schacter DL. When false recognition is unopposed by true recognition: gist-based memory distortion in Alzheimer's disease. Neuropsychology. 2000 Apr; 14(2):277-87.
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  56. Scinto LF, Frosh MP, Daffner KR, Geula C. Neurochemical differences in the Edinger-Westphal and somatic subdivisions of CNIII in Alzheimer?s disease. Society for Neuroscience Abstracts. 2000; 26:536.
  57. Daffner KR, Scinto L, Faust R, Holcomb P. The voluntary component of the novelty P3 response. Society for Neuroscience Abstracts. 2000; 26:2222.
  58. Sitarski J, Budson AE, Daffner KR, Schacter DL. False recognition in Alzheimer?s disease: inability to use the distinctiveness heuristic. Cognitive Neuroscience Society Annual Meeting Program. 2000; 148.
  59. Daffner KR, Scinto LFM, Rentz D, Faust R, Zandman D, Holcomb PJ. Age-related changes in the allocation of attention to novel events. Cognitive Neuroscience Society Annual Meeting Program. 2000; 87.
  60. Michalska KJ, Budson AE, Rentz DM, Daffner KR, Schacter DL. Early diagnosis of Alzheimer?s disease using false recognition. Cognitive Neuroscience Society Annual Meeting Program. 2000; 139.
  61. Daffner KR, Mesulam MM, Holcomb PJ, Calvo V, Acar D, Chabrerie A, Kikinis R, Jolesz FA, Rentz DM, Scinto LF. Disruption of attention to novel events after frontal lobe injury in humans. J Neurol Neurosurg Psychiatry. 2000 Jan; 68(1):18-24.
    View in: PubMed
  62. Greenberg SM, Tennis MK, Brown LB, Gomez-Isla T, Hayden DL, Schoenfeld DA, Walsh KL, Corwin C, Daffner KR, Friedman P, Meadows ME, Sperling RA, Growdon JH. Donepezil therapy in clinical practice: a randomized crossover study. Arch Neurol. 2000 Jan; 57(1):94-9.
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  63. Scinto LF, Wu CK, Firla KM, Daffner KR, Saroff D, Geula C. Focal pathology in the Edinger-Westphal nucleus explains pupillary hypersensitivity in Alzheimer's disease. Acta Neuropathol. 1999 Jun; 97(6):557-64.
    View in: PubMed
  64. Scinto LF, Rentz DM, Potter H, Daffner KR. Pupil assay and Alzheimer's disease: a critical analysis. Neurology. 1999 Feb; 52(3):673-4.
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  65. Rentz D, Calvo V, Daffner K, Sperling RA, Scinto LFM. Impaired awareness of memory deficits in non-depressed highly intelligent elders. Journal of the International Neuropsychological Society. 1999; 5:93.
  66. Daffner KR, Mesulam MM, Cohen LG, Scinto LF. Mechanisms underlying diminished novelty-seeking behavior in patients with probable Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol. 1999 Jan; 12(1):58-66.
    View in: PubMed
  67. Frumin M, Chisholm T, Dickey CC, Daffner KR. Psychiatric and behavioral problems. Neurol Clin. 1998 May; 16(2):521-44.
    View in: PubMed
  68. Daffner KR, Mesulam MM, Scinto LF, Cohen LG, Kennedy BP, West WC, Holcomb PJ. Regulation of attention to novel stimuli by frontal lobes: an event-related potential study. Neuroreport. 1998 Mar 30; 9(5):787-91.
    View in: PubMed
  69. Manoach DS, Weintraub S, Daffner KR, Scinto LF. Deficient antisaccades in the social-emotional processing disorder. Neuroreport. 1997 Mar 3; 8(4):901-5.
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  70. Weintraub S, Daffner KR, Ahern GL, Price BH, Mesulam MM. Right sided hemispatial neglect and bilateral cerebral lesions. J Neurol Neurosurg Psychiatry. 1996 Mar; 60(3):342-4.
    View in: PubMed
  71. Gitelman DR, Alpert NM, Kosslyn S, Daffner K, Scinto L, Thompson W, Mesulam MM. Functional imaging of human right hemispheric activation for exploratory movements. Ann Neurol. 1996 Feb; 39(2):174-9.
    View in: PubMed
  72. Scinto LF, Daffner KR, Dressler D, Ransil BI, Rentz D, Weintraub S, Mesulam M, Potter H. Response. Science. 1995 Mar 17; 267(5204):1580-1.
    View in: PubMed
  73. Scinto LF, Daffner KR, Dressler D, Ransil BI, Rentz D, Weintraub S, Mesulam M, Potter H. A potential noninvasive neurobiological test for Alzheimer's disease. Science. 1994 Nov 11; 266(5187):1051-4.
    View in: PubMed
  74. Scinto LF, Daffner KR, Castro L, Weintraub S, Vavrik M, Mesulam MM. Impairment of spatially directed attention in patients with probable Alzheimer's disease as measured by eye movements. Arch Neurol. 1994 Jul; 51(7):682-8.
    View in: PubMed
  75. Daffner KR, Scinto LF, Weintraub S, Guinessey J, Mesulam MM. The impact of aging on curiosity as measured by exploratory eye movements. Arch Neurol. 1994 Apr; 51(4):368-76.
    View in: PubMed
  76. Daffner KR, Scinto LF, Weintraub S, Guinessey JE, Mesulam MM. Diminished curiosity in patients with probable Alzheimer's disease as measured by exploratory eye movements. Neurology. 1992 Feb; 42(2):320-8.
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  77. Sandson TA, Daffner KR, Carvalho PA, Mesulam MM. Frontal lobe dysfunction following infarction of the left-sided medial thalamus. Arch Neurol. 1991 Dec; 48(12):1300-3.
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  78. Daffner KR, Schomer DL, Cosgrove GR, Rubin N, Mesulam MM. Broca's aphasia following damage to Wernicke's area. For or against traditional aphasiology? Arch Neurol. 1991 Jul; 48(7):766-8.
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  79. Price BH, Daffner KR, Stowe RM, Mesulam MM. The comportmental learning disabilities of early frontal lobe damage. Brain. 1990 Oct; 113 ( Pt 5):1383-93.
    View in: PubMed
  80. Daffner KR, Ahern GL, Weintraub S, Mesulam MM. Dissociated neglect behavior following sequential strokes in the right hemisphere. Ann Neurol. 1990 Jul; 28(1):97-101.
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  81. Daffner KR, Saver JL, Biber MP. Lyme polyradiculoneuropathy presenting as increasing abdominal girth. Neurology. 1990 Feb; 40(2):373-5.
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  82. Rogers MP, Trentham DE, Dynesius-Trentham R, Daffner K, Reich P. Exacerbation of collagen arthritis by noise stress. J Rheumatol. 1983 Aug; 10(4):651-4.
    View in: PubMed
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