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Melanie Haas Kucherlapati, Ph.D.

TitleInstructor in Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressHarvard Medical School
Genetics, #160
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-4438
Fax617/525-4570

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kucherlapati MH, Esfahani S, Habibollahi P, Wang J, Still ER, Bronson RT, Mahmood U, Kucherlapati RS. Genotype directed therapy in murine mismatch repair deficient tumors. PLoS One. 2013; 8(7):e68817.
    View in: PubMed
  2. Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC. Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice. PLoS One. 2012; 7(9):e44273.
    View in: PubMed
  3. McIlhatton MA, Tyler J, Kerepesi LA, Bocker-Edmonston T, Kucherlapati MH, Edelmann W, Kucherlapati R, Kopelovich L, Fishel R. Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model. Cancer Prev Res (Phila). 2011 May; 4(5):684-93.
    View in: PubMed
  4. McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, Marchuk DA. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet. 2011 Jan 15; 20(2):211-22.
    View in: PubMed
  5. Kucherlapati MH, Lee K, Nguyen AA, Clark AB, Hou H, Rosulek A, Li H, Yang K, Fan K, Lipkin M, Bronson RT, Jelicks L, Kunkel TA, Kucherlapati R, Edelmann W. An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar; 138(3):993-1002.e1.
    View in: PubMed
  6. Kucherlapati MH, Yang K, Fan K, Kuraguchi M, Sonkin D, Rosulek A, Lipkin M, Bronson RT, Aronow BJ, Kucherlapati R. Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. Proc Natl Acad Sci U S A. 2008 Oct 7; 105(40):15493-8.
    View in: PubMed
  7. Kucherlapati M, Nguyen A, Kuraguchi M, Yang K, Fan K, Bronson R, Wei K, Lipkin M, Edelmann W, Kucherlapati R. Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies. Oncogene. 2007 Sep 20; 26(43):6297-306.
    View in: PubMed
  8. Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R. Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006 Sep 15; 2(9):e146.
    View in: PubMed
  9. Kucherlapati MH, Nguyen AA, Bronson RT, Kucherlapati RS. Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract. Cancer Res. 2006 Apr 1; 66(7):3576-83.
    View in: PubMed
  10. Kucherlapati M, Yang K, Kuraguchi M, Zhao J, Lia M, Heyer J, Kane MF, Fan K, Russell R, Brown AM, Kneitz B, Edelmann W, Kolodner RD, Lipkin M, Kucherlapati R. Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9924-9.
    View in: PubMed
  11. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000 Sep; 6(9):991-7.
    View in: PubMed
  12. Edelmann W, Umar A, Yang K, Heyer J, Kucherlapati M, Lia M, Kneitz B, Avdievich E, Fan K, Wong E, Crouse G, Kunkel T, Lipkin M, Kolodner RD, Kucherlapati R. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res. 2000 Feb 15; 60(4):803-7.
    View in: PubMed
  13. Lin X, State MW, Vaccarino FM, Greally J, Hass M, Leckman JF. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). Genomics. 1999 Aug 15; 60(1):96-104.
    View in: PubMed
  14. Lin X, Swaroop A, Vaccarino FM, Murtha MT, Haas M, Ji X, Ruddle FH, Leckman JF. Characterization and sequence analysis of the human homeobox-containing gene GBX2. Genomics. 1996 Feb 1; 31(3):335-42.
    View in: PubMed
  15. Krainc D, Haas M, Ward DC, Lipton SA, Bruns G, Leifer D. Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved. Genomics. 1995 Oct 10; 29(3):809-11.
    View in: PubMed
  16. Payne JA, Xu JC, Haas M, Lytle CY, Ward D, Forbush B. Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon. J Biol Chem. 1995 Jul 28; 270(30):17977-85.
    View in: PubMed
  17. George AL, Varkony TA, Drabkin HA, Han J, Knops JF, Finley WH, Brown GB, Ward DC, Haas M. Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21. Cytogenet Cell Genet. 1995; 68(1-2):67-70.
    View in: PubMed
  18. Aburatani, H., Stanton, V.P., Bernardini, J., Haas, M., Ward,D.C., Housman, D. Cytogenetics and Cell Genetics. Construction of a YAC contig spanning 20 megabases in human chromosome 3p14-21. 1995; (68):125-146.
  19. Munroe DJ, Haas M, Bric E, Whitton T, Aburatani H, Hunter K, Ward D, Housman DE. IRE-bubble PCR: a rapid method for efficient and representative amplification of human genomic DNA sequences from complex sources. Genomics. 1994 Feb; 19(3):506-14.
    View in: PubMed
  20. Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B. Localization of Shaw-related K+ channel genes on mouse and human chromosomes. Mamm Genome. 1993 Dec; 4(12):711-5.
    View in: PubMed
  21. Haas M, Aburatani H, Stanton VP, Bhatt M, Housman D, Ward DC. Isolation and FISH mapping of 80 cosmid clones on the short arm of human chromosome 3. Genomics. 1993 Apr; 16(1):90-6.
    View in: PubMed
  22. Haas MW, Ramanujam P, Chandrasekharappa SC, Subramanian KN. Sequence requirements for activation of replication by the SV40 transcriptional promoter or enhancer elements. Virology. 1991 Jan; 180(1):41-8.
    View in: PubMed
  23. Haas MW, Becker JM, Miller RV. Peptidase activity in the inner membrane of Pseudomonas aeruginosa. Biochim Biophys Acta. 1981 Apr 22; 643(1):256-60.
    View in: PubMed
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