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J. Perren Cobb, M.D.

TitleAssociate Professor of Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
Grb 444
55 Fruit St
Boston MA 02114
Phone617/726-3030
Fax617/726-3032
Other Positions
TitleAssociate Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia


 Overview 
 overview
Dr. Cobb is Director of the MGH Critical Care Center, Vice-Chair for Critical Care in the Department of Anesthesia, Critical Care, and Pain Medicine at MGH, Faculty Affiliate of the Harvard Stem Cell Institute, and Associate Professor of Anaesthesia and Surgery at HMS. His clinical and research focus is improving outcomes in patients with multiple organ dysfunction syndrome or MODS. Working with other investigators at Harvard-affiliated hospitals and institutions, he is exploring the application of systems, cellular, and molecular engineering to better reanimate the critically ill and injured ("health engineering"). In addition to his work in Boston, Dr. Cobb also directs the United States Critical Illness and Injury Trials (USCIIT) Group, funded by the NIH to foster investigator-initiated hypothesis testing and strategic planning for clinical research.


 Mentoring 
 current student opportunities
Available: 09/01/11, Expires: 07/01/13

The future of intensive care requires integrating advances in biomedical and engineering sciences. This Program tests the hypothesis that application of systems, cellular, and molecular engineering will improve outcomes, aiming to engineer health in our most vulnerable patient population. The MGH Reanimation Unit, a new 20 bed intensive care unit (ICU), is the new testing ground for this interface. HMS Scholars will work with their clinical mentors and with colleagues from systems engineering, management, regenerative medicine, and/or genetics to tailor a program to their specific interests and professional aspirations. Examples of current projects include quantitative modeling of patient flow through the hospital, ICU quality and value dashboards, measuring effectiveness of process improvement interventions, testing efficacy of telemedicine, and stem cell therapy for organ dysfunction.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Blum JM, Morris PE, Martin GS, Gong MN, Bhagwanjee S, Cairns CB, Cobb JP. United States critical illness and injury trials group. Chest. 2013 Mar 1; 143(3):808-13.
    View in: PubMed
  2. van der Wilden GM, Schmidt U, Chang Y, Bittner EA, Cobb JP, Velmahos GC, Alam HB, de Moya MA, King DR. Implementation of 24/7 intensivist presence in the SICU: Effect on processes of care. J Trauma Acute Care Surg. 2013 Feb; 74(2):563-7.
    View in: PubMed
  3. Cuschieri J, Johnson JL, Sperry J, West MA, Moore EE, Minei JP, Bankey PE, Nathens AB, Cuenca AG, Efron PA, Hennessy L, Xiao W, Mindrinos MN, McDonald-Smith GP, Mason PH, Billiar TR, Schoenfeld DA, Warren HS, Cobb JP, Moldawer LL, Davis RW, Maier RV, Tompkins RG. Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg. 2012 May; 255(5):993-9.
    View in: PubMed
  4. Kasotakis G, Schmidt U, Perry D, Grosse-Sundrup M, Benjamin J, Ryan C, Tully S, Hirschberg R, Waak K, Velmahos G, Bittner EA, Zafonte R, Cobb JP, Eikermann M. The surgical intensive care unit optimal mobility score predicts mortality and length of stay. Crit Care Med. 2012 Apr; 40(4):1122-8.
    View in: PubMed
  5. Cooper ZR, Powers CL, Cobb JP. Putting the patient first: honoring advance directives prior to surgery. Ann Surg. 2012 Mar; 255(3):424-6.
    View in: PubMed
  6. Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG. A genomic storm in critically injured humans. J Exp Med. 2011 Dec 19; 208(13):2581-90.
    View in: PubMed
  7. Cobb JP, Hayden DL, Schoenfeld DA. Novel diagnostics for sepsis: a decade of promise for gene expression profiling. Crit Care Med. 2011 Nov; 39(11):2579-81.
    View in: PubMed
  8. Werner JA, Schierding W, Dixon D, Macmillan S, Oppedal D, Muenzer J, Cobb JP, Checchia PA. Preliminary evidence for leukocyte transcriptional signatures for pediatric ventilator-associated pneumonia. J Intensive Care Med. 2012 Nov; 27(6):362-9.
    View in: PubMed
  9. Norris PR, Cobb JP. Ten years later, still "gene in a haystack?". Crit Care Med. 2011 May; 39(5):1231-2.
    View in: PubMed
  10. Cobb JP. MORE for multiple organ dysfunction syndrome: Multiple Organ REanimation, REgeneration, and REprogramming. Crit Care Med. 2010 Nov; 38(11):2242-6.
    View in: PubMed
  11. Johnson DW, Cobb JP. Candida infection and colonization in critically ill surgical patients. Virulence. 2010 Sep-Oct; 1(5):355-6.
    View in: PubMed
  12. Sarder P, Schierding W, Cobb JP, Nehorai A. Estimating sparse gene regulatory networks using a bayesian linear regression. IEEE Trans Nanobioscience. 2010 Jun; 9(2):121-31.
    View in: PubMed
  13. Muenzer JT, Jaffe DM, Schwulst SJ, Dixon DJ, Schierding WS, Li Q, MacMillan SK, Oppedal D, Warner BW, Dillon PA, Lin N, Checchia PA, Cobb JP. Evidence for a novel blood RNA diagnostic for pediatric appendicitis: the riboleukogram. Pediatr Emerg Care. 2010 May; 26(5):333-8.
    View in: PubMed
  14. Fowler RA, Webb SA, Rowan KM, Sprung CL, Thompson BT, Randolph AG, Jouvet P, Lapinsky S, Rubinson L, Rello J, Cobb JP, Rice TW, Uyeki T, Marshall JC. Early observational research and registries during the 2009-2010 influenza A pandemic. Crit Care Med. 2010 Apr; 38(4 Suppl):e120-32.
    View in: PubMed
  15. Cobb JP. Engineering health in the intensive care unit. Arch Intern Med. 2010 Feb 22; 170(4):319-20.
    View in: PubMed
  16. McConnell KW, McDunn JE, Clark AT, Dunne WM, Dixon DJ, Turnbull IR, Dipasco PJ, Osberghaus WF, Sherman B, Martin JR, Walter MJ, Cobb JP, Buchman TG, Hotchkiss RS, Coopersmith CM. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med. 2010 Jan; 38(1):223-41.
    View in: PubMed
  17. Winfield RD, Delano MJ, Dixon DJ, Schierding WS, Cendan JC, Lottenberg L, Lopez MC, Baker HV, Cobb JP, Moldawer LL, Maier RV, Cuschieri J. Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic response. Crit Care Med. 2010 Jan; 38(1):51-8.
    View in: PubMed
  18. Cobb JP, Ognibene FP, Ingbar DH, Mann HJ, Hoyt DB, Angus DC, Thomas AV, Danner RL, Suffredini AF. Forging a critical alliance: Addressing the research needs of the United States critical illness and injury community. Crit Care Med. 2009 Dec; 37(12):3158-60.
    View in: PubMed
  19. Cobb JP, Moore EE, Hayden DL, Minei JP, Cuschieri J, Yang J, Li Q, Lin N, Brownstein BH, Hennessy L, Mason PH, Schierding WS, Dixon DJ, Tompkins RG, Warren HS, Schoenfeld DA, Maier RV. Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury. Ann Surg. 2009 Oct; 250(4):531-9.
    View in: PubMed
  20. Shelton AK, Fish AF, Cobb JP, Bachman JA, Jenkins RL, Battistich V, Freeman BD. Surrogate consent for genomics research in intensive care. Am J Crit Care. 2009 Sep; 18(5):418-26; quiz 427.
    View in: PubMed
  21. Cobb JP, Cairns CB, Bulger E, Wong HR, Parsons PE, Angus DC, Gentile NT, Hoyt DB, Schwinn DA, Wiener-Kronish JP, Upperman JS. The United States critical illness and injury trials group: an introduction. J Trauma. 2009 Aug; 67(2 Suppl):S159-60.
    View in: PubMed
  22. Warren HS, Elson CM, Hayden DL, Schoenfeld DA, Cobb JP, Maier RV, Moldawer LL, Moore EE, Harbrecht BG, Pelak K, Cuschieri J, Herndon DN, Jeschke MG, Finnerty CC, Brownstein BH, Hennessy L, Mason PH, Tompkins RG. A genomic score prognostic of outcome in trauma patients. Mol Med. 2009 Jul-Aug; 15(7-8):220-7.
    View in: PubMed
  23. Polpitiya AD, McDunn JE, Burykin A, Ghosh BK, Cobb JP. Using systems biology to simplify complex disease: immune cartography. Crit Care Med. 2009 Jan; 37(1 Suppl):S16-21.
    View in: PubMed
  24. Cobb JP, Suffredini AF, Danner RL. The Fourth National Institutes of Health Symposium on the Functional Genomics of Critical Injury: Surviving stress from organ systems to molecules. Crit Care Med. 2008 Oct; 36(10):2905-11.
    View in: PubMed
  25. Checchia PA, Schierding W, Polpitiya A, Dixon D, Macmillan S, Muenzer J, Stromberg P, Coopersmith CM, Buchman TG, Cobb JP. Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age. Pediatr Crit Care Med. 2008 Sep; 9(5):530-5.
    View in: PubMed
  26. Cobb JP, Suffredini AF, Danner RL. Functional genomics of critical illness and injury: Fourth National Institute of Health Symposium: Surviving stress: Organ systems to molecules. Crit Care Med. 2008 Aug 28.
    View in: PubMed
  27. Laramie JM, Chung TP, Brownstein B, Stormo GD, Cobb JP. Transcriptional profiles of human epithelial cells in response to heat: computational evidence for novel heat shock proteins. Shock. 2008 May; 29(5):623-30.
    View in: PubMed
  28. McDunn JE, Husain KD, Polpitiya AD, Burykin A, Ruan J, Li Q, Schierding W, Lin N, Dixon D, Zhang W, Coopersmith CM, Dunne WM, Colonna M, Ghosh BK, Cobb JP. Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram. PLoS One. 2008; 3(2):e1564.
    View in: PubMed
  29. Lederer JA, Brownstein BH, Lopez MC, Macmillan S, Delisle AJ, Macconmara MP, Choudhry MA, Xiao W, Lekousi S, Cobb JP, Baker HV, Mannick JA, Chaudry IH. Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiol Genomics. 2008 Feb 19; 32(3):299-310.
    View in: PubMed
  30. McDunn JE, Townsend RR, Cobb JP. The murine plasma protein response to polymicrobial intra-abdominal sepsis. Proteomics Clin Appl. 2007 Apr; 1(4):373-86.
    View in: PubMed
  31. Wagner TH, Drewry AM, Macmillan S, Dunne WM, Chang KC, Karl IE, Hotchkiss RS, Cobb JP. Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo. Am J Physiol Regul Integr Comp Physiol. 2007 Apr; 292(4):R1751-9.
    View in: PubMed
  32. Chung TP, Laramie JM, Meyer DJ, Downey T, Tam LH, Ding H, Buchman TG, Karl I, Stormo GD, Hotchkiss RS, Cobb JP. Molecular diagnostics in sepsis: from bedside to bench. J Am Coll Surg. 2006 Nov; 203(5):585-598.
    View in: PubMed
  33. McDunn JE, Turnbull IR, Polpitiya AD, Tong A, MacMillan SK, Osborne DF, Hotchkiss RS, Colonna M, Cobb JP. Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis. J Am Coll Surg. 2006 Sep; 203(3):365-75.
    View in: PubMed
  34. Van Vickle-Chavez SJ, Tung WS, Absi TS, Ennis TL, Mao D, Cobb JP, Thompson RW. Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms. J Vasc Surg. 2006 May; 43(5):1010-20.
    View in: PubMed
  35. Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ, Dunne JC, Dietz GP, Bähr M, McDunn JE, Karl IE, Wagner TH, Cobb JP, Coopersmith CM, Piwnica-Worms D. TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol. 2006 May 1; 176(9):5471-7.
    View in: PubMed
  36. McDunn JE, Chung TP, Laramie JM, Townsend RR, Cobb JP. Physiologic genomics. Surgery. 2006 Feb; 139(2):133-9.
    View in: PubMed
  37. Brownstein BH, Logvinenko T, Lederer JA, Cobb JP, Hubbard WJ, Chaudry IH, Remick DG, Baker HV, Xiao W, Mannick JA. Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiol Genomics. 2006 Feb 14; 24(3):298-309.
    View in: PubMed
  38. Barchet W, Price JD, Cella M, Colonna M, MacMillan SK, Cobb JP, Thompson PA, Murphy KM, Atkinson JP, Kemper C. Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood. 2006 Feb 15; 107(4):1497-504.
    View in: PubMed
  39. Cobb JP. Fundamentals of surgical research course: functional genomics. J Surg Res. 2005 Oct; 128(2):194-8.
    View in: PubMed
  40. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF. A network-based analysis of systemic inflammation in humans. Nature. 2005 Oct 13; 437(7061):1032-7.
    View in: PubMed
  41. Turnbull IR, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J Exp Med. 2005 Aug 1; 202(3):363-9.
    View in: PubMed
  42. McDunn JE, Cobb JP. That which does not kill you makes you stronger: a molecular mechanism for preconditioning. Sci STKE. 2005 Jul 5; 2005(291):pe34.
    View in: PubMed
  43. Cobb JP. Uniting the voices of academic surgery: the role of the young voice. J Surg Res. 2005 Jun 15; 126(2):131-6.
    View in: PubMed
  44. Cobb JP, Warner BW. Challenges and a new vision for academic surgery. J Am Coll Surg. 2005 Apr; 200(4):605-6.
    View in: PubMed
  45. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13):4801-6.
    View in: PubMed
  46. Dilley WG, Kalyanaraman S, Verma S, Cobb JP, Laramie JM, Lairmore TC. Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome. Mol Cancer. 2005 Feb 3; 4(1):9.
    View in: PubMed
  47. Feezor RJ, Baker HV, Mindrinos M, Hayden D, Tannahill CL, Brownstein BH, Fay A, MacMillan S, Laramie J, Xiao W, Moldawer LL, Cobb JP, Laudanski K, Miller-Graziano CL, Maier RV, Schoenfeld D, Davis RW, Tompkins RG. Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics. 2004 Nov 17; 19(3):247-54.
    View in: PubMed
  48. Wizorek JJ, Coopersmith CM, Laramie JM, Tong A, Stromberg PE, Hotchkiss RS, Buchman TG, Cobb JP. Sequence makes a difference: paradoxical effects of stress in vivo. Shock. 2004 Sep; 22(3):229-33.
    View in: PubMed
  49. Cobb JP, O'Keefe GE. Injury research in the genomic era. Lancet. 2004 Jun 19; 363(9426):2076-83.
    View in: PubMed
  50. Dasu MR, Cobb JP, Laramie JM, Chung TP, Spies M, Barrow RE. Gene expression profiles of livers from thermally injured rats. Gene. 2004 Feb 18; 327(1):51-60.
    View in: PubMed
  51. Cobb JP, Laramie JM, Stormo GD, Morrissey JJ, Shannon WD, Qiu Y, Karl IE, Buchman TG, Hotchkiss RS. Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. Crit Care Med. 2002 Dec; 30(12):2711-21.
    View in: PubMed
  52. Hotchkiss RS, Tinsley KW, Swanson PE, Grayson MH, Osborne DF, Wagner TH, Cobb JP, Coopersmith C, Karl IE. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol. 2002 Mar 1; 168(5):2493-500.
    View in: PubMed
  53. Chung TP, Laramie JM, Province M, Cobb JP. Functional genomics of critical illness and injury. Crit Care Med. 2002 Jan; 30(1 Suppl):S51-7.
    View in: PubMed
  54. Barnard GF, Mori M, Staniunas RJ, Begum NA, Bao S, Puder M, Cobb J, Redman KL, Steele GD, Chen LB. Ubiquitin fusion proteins are overexpressed in colon cancer but not in gastric cancer. Biochim Biophys Acta. 1995 Dec 12; 1272(3):147-53.
    View in: PubMed
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