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David J. Filman, Ph.D.

TitleLecturer on Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
AddressHarvard Medical School
Dept. of B.C.M.P.
240 Longwood Ave
Boston MA 02115
Phone617/432-3919

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Strauss M, Levy HC, Bostina M, Filman DJ, Hogle JM. RNA Transfer from Poliovirus 135S Particles across Membranes Is Mediated by Long Umbilical Connectors. J Virol. 2013 Apr; 87(7):3903-14.
    View in: PubMed
  2. Lin J, Lee LY, Roivainen M, Filman DJ, Hogle JM, Belnap DM. Structure of the Fab-labeled "breathing" state of native poliovirus. J Virol. 2012 May; 86(10):5959-62.
    View in: PubMed
  3. Lin J, Cheng N, Chow M, Filman DJ, Steven AC, Hogle JM, Belnap DM. An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles. J Virol. 2011 Oct; 85(19):9974-83.
    View in: PubMed
  4. Bostina M, Levy H, Filman DJ, Hogle JM. Poliovirus RNA is released from the capsid near a twofold symmetry axis. J Virol. 2011 Jan; 85(2):776-83.
    View in: PubMed
  5. Levy HC, Bostina M, Filman DJ, Hogle JM. Catching a virus in the act of RNA release: a novel poliovirus uncoating intermediate characterized by cryo-electron microscopy. J Virol. 2010 May; 84(9):4426-41.
    View in: PubMed
  6. Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM. The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. J Virol. 2009 Dec; 83(23):12215-28.
    View in: PubMed
  7. Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM. The human cytomegalovirus UL44 C clamp wraps around DNA. Structure. 2008 Aug 6; 16(8):1214-25.
    View in: PubMed
  8. Bubeck D, Filman DJ, Kuzmin M, Fuller SD, Hogle JM. Post-imaging fiducial markers aid in the orientation determination of complexes with mixed or unknown symmetry. J Struct Biol. 2008 Jun; 162(3):480-90.
    View in: PubMed
  9. Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM. The positively charged surface of herpes simplex virus UL42 mediates DNA binding. J Biol Chem. 2008 Mar 7; 283(10):6154-61.
    View in: PubMed
  10. Bostina M, Bubeck D, Schwartz C, Nicastro D, Filman DJ, Hogle JM. Single particle cryoelectron tomography characterization of the structure and structural variability of poliovirus-receptor-membrane complex at 30 A resolution. J Struct Biol. 2007 Nov; 160(2):200-10.
    View in: PubMed
  11. Baron MJ, Filman DJ, Prophete GA, Hogle JM, Madoff LC. Identification of a glycosaminoglycan binding region of the alpha C protein that mediates entry of group B Streptococci into host cells. J Biol Chem. 2007 Apr 6; 282(14):10526-36.
    View in: PubMed
  12. Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM. Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. J Virol. 2007 Apr; 81(7):3583-96.
    View in: PubMed
  13. Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM. Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. J Biol Chem. 2006 Feb 24; 281(8):5224-32.
    View in: PubMed
  14. Biswas T, Aihara H, Radman-Livaja M, Filman D, Landy A, Ellenberger T. A structural basis for allosteric control of DNA recombination by lambda integrase. Nature. 2005 Jun 23; 435(7045):1059-66.
    View in: PubMed
  15. Bubeck D, Filman DJ, Hogle JM. Cryo-electron microscopy reconstruction of a poliovirus-receptor-membrane complex. Nat Struct Mol Biol. 2005 Jul; 12(7):615-8.
    View in: PubMed
  16. Bubeck D, Filman DJ, Cheng N, Steven AC, Hogle JM, Belnap DM. The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes. J Virol. 2005 Jun; 79(12):7745-55.
    View in: PubMed
  17. Aupérin TC, Bolduc GR, Baron MJ, Heroux A, Filman DJ, Madoff LC, Hogle JM. Crystal structure of the N-terminal domain of the group B streptococcus alpha C protein. J Biol Chem. 2005 May 6; 280(18):18245-52.
    View in: PubMed
  18. Guogas LM, Filman DJ, Hogle JM, Gehrke L. Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication. Science. 2004 Dec 17; 306(5704):2108-11.
    View in: PubMed
  19. Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM. The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Mol Cell. 2004 Jul 23; 15(2):233-44.
    View in: PubMed
  20. Chang JF, Hall BE, Tanny JC, Moazed D, Filman D, Ellenberger T. Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3. Structure. 2003 Jun; 11(6):637-49.
    View in: PubMed
  21. Joseph-McCarthy D, Tsang SK, Filman DJ, Hogle JM, Karplus M. Use of MCSS to design small targeted libraries: application to picornavirus ligands. J Am Chem Soc. 2001 Dec 26; 123(51):12758-69.
    View in: PubMed
  22. Miller ST, Hogle JM, Filman DJ. Ab initio phasing of high-symmetry macromolecular complexes: successful phasing of authentic poliovirus data to 3.0 A resolution. J Mol Biol. 2001 Mar 23; 307(2):499-512.
    View in: PubMed
  23. Weiss VH, McBride AE, Soriano MA, Filman DJ, Silver PA, Hogle JM. The structure and oligomerization of the yeast arginine methyltransferase, Hmt1. Nat Struct Biol. 2000 Dec; 7(12):1165-71.
    View in: PubMed
  24. Zuccola HJ, Filman DJ, Coen DM, Hogle JM. The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase. Mol Cell. 2000 Feb; 5(2):267-78.
    View in: PubMed
  25. Belnap DM, Filman DJ, Trus BL, Cheng N, Booy FP, Conway JF, Curry S, Hiremath CN, Tsang SK, Steven AC, Hogle JM. Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus. J Virol. 2000 Feb; 74(3):1342-54.
    View in: PubMed
  26. Belnap DM, McDermott BM, Filman DJ, Cheng N, Trus BL, Zuccola HJ, Racaniello VR, Hogle JM, Steven AC. Three-dimensional structure of poliovirus receptor bound to poliovirus. Proc Natl Acad Sci U S A. 2000 Jan 4; 97(1):73-8.
    View in: PubMed
  27. Anderson AC, O'Neil RH, Filman DJ, Frederick CA. Crystal structure of a brominated RNA helix with four mismatched base pairs: An investigation into RNA conformational variability. Biochemistry. 1999 Sep 28; 38(39):12577-85.
    View in: PubMed
  28. Trikha J, Filman DJ, Hogle JM. Crystal structure of a 14 bp RNA duplex with non-symmetrical tandem GxU wobble base pairs. Nucleic Acids Res. 1999 Apr 1; 27(7):1728-39.
    View in: PubMed
  29. Filman DJ, Wien MW, Cunningham JA, Bergelson JM, Hogle JM. Structure determination of echovirus 1. Acta Crystallogr D Biol Crystallogr. 1998 Nov 1; 54(Pt 6 Pt 2):1261-72.
    View in: PubMed
  30. Grant RA, Filman DJ, Finkel SE, Kolter R, Hogle JM. The crystal structure of Dps, a ferritin homolog that binds and protects DNA. Nat Struct Biol. 1998 Apr; 5(4):294-303.
    View in: PubMed
  31. Hiremath CN, Filman DJ, Grant RA, Hogle JM. Ligand-induced conformational changes in poliovirus-antiviral drug complexes. Acta Crystallogr D Biol Crystallogr. 1997 Sep 1; 53(Pt 5):558-70.
    View in: PubMed
  32. Wien MW, Curry S, Filman DJ, Hogle JM. Structural studies of poliovirus mutants that overcome receptor defects. Nat Struct Biol. 1997 Aug; 4(8):666-74.
    View in: PubMed
  33. Jacobson DH, Hogle JM, Filman DJ. A pseudo-cell based approach to efficient crystallographic refinement of viruses. Acta Crystallogr D Biol Crystallogr. 1996 Jul 1; 52(Pt 4):693-711.
    View in: PubMed
  34. Miller ST, Hogle JM, Filman DJ. A genetic algorithm for the ab initio phasing of icosahedral viruses. Acta Crystallogr D Biol Crystallogr. 1996 Mar 1; 52(Pt 2):235-51.
    View in: PubMed
  35. Benson TE, Filman DJ, Walsh CT, Hogle JM. An enzyme-substrate complex involved in bacterial cell wall biosynthesis. Nat Struct Biol. 1995 Aug; 2(8):644-53.
    View in: PubMed
  36. Hiremath CN, Grant RA, Filman DJ, Hogle JM. Binding of the antiviral drug WIN51711 to the sabin strain of type 3 poliovirus: structural comparison with drug binding in rhinovirus 14. Acta Crystallogr D Biol Crystallogr. 1995 Jul 1; 51(Pt 4):473-89.
    View in: PubMed
  37. Wien MW, Filman DJ, Stura EA, Guillot S, Delpeyroux F, Crainic R, Hogle JM. Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope. Nat Struct Biol. 1995 Mar; 2(3):232-43.
    View in: PubMed
  38. Basavappa R, Syed R, Flore O, Icenogle JP, Filman DJ, Hogle JM. Role and mechanism of the maturation cleavage of VP0 in poliovirus assembly: structure of the empty capsid assembly intermediate at 2.9 A resolution. Protein Sci. 1994 Oct; 3(10):1651-69.
    View in: PubMed
  39. Grant RA, Hiremath CN, Filman DJ, Syed R, Andries K, Hogle JM. Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design. Curr Biol. 1994 Sep 1; 4(9):784-97.
    View in: PubMed
  40. Grant RA, Filman DJ, Fujinami RS, Icenogle JP, Hogle JM. Three-dimensional structure of Theiler virus. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2061-5.
    View in: PubMed
  41. Yeates TO, Jacobson DH, Martin A, Wychowski C, Girard M, Filman DJ, Hogle JM. Three-dimensional structure of a mouse-adapted type 2/type 1 poliovirus chimera. EMBO J. 1991 Sep; 10(9):2331-41.
    View in: PubMed
  42. Filman DJ, Hogle JM. Virology. Architecture with a difference. Nature. 1991 May 9; 351(6322):100-1.
    View in: PubMed
  43. Hogle JM, Filman DJ. The antigenic structure of poliovirus. Philos Trans R Soc Lond B Biol Sci. 1989 Jun 12; 323(1217):467-78.
    View in: PubMed
  44. Filman DJ, Syed R, Chow M, Macadam AJ, Minor PD, Hogle JM. Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus. EMBO J. 1989 May; 8(5):1567-79.
    View in: PubMed
  45. Hogle JM, Filman DJ. Poliovirus: three-dimensional structure of a viral antigen. Adv Vet Sci Comp Med. 1989; 33:65-91.
    View in: PubMed
  46. Ypma-Wong MF, Filman DJ, Hogle JM, Semler BL. Structural domains of the poliovirus polyprotein are major determinants for proteolytic cleavage at Gln-Gly pairs. J Biol Chem. 1988 Nov 25; 263(33):17846-56.
    View in: PubMed
  47. Page GS, Mosser AG, Hogle JM, Filman DJ, Rueckert RR, Chow M. Three-dimensional structure of poliovirus serotype 1 neutralizing determinants. J Virol. 1988 May; 62(5):1781-94.
    View in: PubMed
  48. Chow M, Newman JF, Filman D, Hogle JM, Rowlands DJ, Brown F. Myristylation of picornavirus capsid protein VP4 and its structural significance. Nature. 1987 Jun 11-17; 327(6122):482-6.
    View in: PubMed
  49. Hogle JM, Chow M, Filman DJ. The structure of poliovirus. Sci Am. 1987 Mar; 256(3):42-9.
    View in: PubMed
  50. Hogle JM, Chow M, Filman DJ. Three-dimensional structure of poliovirus at 2.9 A resolution. Science. 1985 Sep 27; 229(4720):1358-65.
    View in: PubMed
  51. Matthews DA, Bolin JT, Burridge JM, Filman DJ, Volz KW, Kaufman BT, Beddell CR, Champness JN, Stammers DK, Kraut J. Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. J Biol Chem. 1985 Jan 10; 260(1):381-91.
    View in: PubMed
  52. Matthews DA, Bolin JT, Burridge JM, Filman DJ, Volz KW, Kraut J. Dihydrofolate reductase. The stereochemistry of inhibitor selectivity. J Biol Chem. 1985 Jan 10; 260(1):392-9.
    View in: PubMed
  53. Bolin JT, Filman DJ, Matthews DA, Hamlin RC, Kraut J. Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. J Biol Chem. 1982 Nov 25; 257(22):13650-62.
    View in: PubMed
  54. Filman DJ, Bolin JT, Matthews DA, Kraut J. Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis. J Biol Chem. 1982 Nov 25; 257(22):13663-72.
    View in: PubMed
  55. Matthews DA, Alden RA, Bolin JT, Filman DJ, Freer ST, Hamlin R, Hol WG, Kisliuk RL, Pastore EJ, Plante LT, Xuong N, Kraut J. Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex. J Biol Chem. 1978 Oct 10; 253(19):6946-54.
    View in: PubMed
  56. Filman DJ, Brawn RJ, Dandliker WB. Intracellular supravital stain delocalization as an assay for antibody-dependent complement-mediated cell damage. J Immunol Methods. 1975 Jan; 6(3):189-207.
    View in: PubMed
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