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Keywords
Last Name
Institution

Robert S. Langer, SC.D.

TitleSenior Lecturer on Surgery
InstitutionMassachusetts Institute of Technology
DepartmentSurgery
AddressMIT - Bldg E25-342
Cambridge MA 02139
Phone617/253-3107
Fax617/258-8827
Other Positions
TitleMember of the Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


 Mentoring 
 completed student projects
Development of a Chlorhexidine Polymer Drug Delivery Vehicle fo rthe Treatment of Periodontal Disease
Part Time/Continuation, 09/01/99 - 06/30/00
Polyorthoester-Based Microspheres as Potentail Endosomolytic Transfection Modulators
Summer, 05/22/00 - 08/31/00

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Levenberg S, Ferreira LS, Chen-Konak L, Kraehenbuehl TP, Langer R. Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells. Nat Protoc. 2010 Jun; 5(6):1115-26.
    View in: PubMed
  2. Luo Y, Kobler JB, Heaton JT, Jia X, Zeitels SM, Langer R. Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold. J Biomed Mater Res B Appl Biomater. 2010 May; 93(2):386-93.
    View in: PubMed
  3. Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG. Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PLoS One. 2010; 5(4):e10032.
    View in: PubMed
  4. Wang AZ, Yuet K, Zhang L, Gu FX, Huynh-Le M, Radovic-Moreno AF, Kantoff PW, Bander NH, Langer R, Farokhzad OC. ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation. Nanomedicine (Lond). 2010 Apr; 5(3):361-8.
    View in: PubMed
  5. Epstein-Barash H, Orbey G, Polat BE, Ewoldt RH, Feshitan J, Langer R, Borden MA, Kohane DS. A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. Biomaterials. 2010 Jul; 31(19):5208-17.
    View in: PubMed
  6. Seto JE, Polat BE, Lopez RF, Blankschtein D, Langer R. Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin. J Control Release. 2010 Jul 1; 145(1):26-32.
    View in: PubMed
  7. Mu CJ, Lavan DA, Langer RS, Zetter BR. Self-assembled gold nanoparticle molecular probes for detecting proteolytic activity in vivo. ACS Nano. 2010 Mar 23; 4(3):1511-20.
    View in: PubMed
  8. Valencia PM, Basto PA, Zhang L, Rhee M, Langer R, Farokhzad OC, Karnik R. Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. ACS Nano. 2010 Mar 23; 4(3):1671-9.
    View in: PubMed
  9. Fisher OZ, Khademhosseini A, Langer R, Peppas NA. Bioinspired materials for controlling stem cell fate. Acc Chem Res. 2010 Mar 16; 43(3):419-28.
    View in: PubMed
  10. Shapiro MG, Westmeyer GG, Romero PA, Szablowski JO, Küster B, Shah A, Otey CR, Langer R, Arnold FH, Jasanoff A. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Nat Biotechnol. 2010 Mar; 28(3):264-70.
    View in: PubMed
  11. Pritchard CD, Slotkin JR, Yu D, Dai H, Lawrence MS, Bronson RT, Reynolds FM, Teng YD, Woodard EJ, Langer RS. Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells. J Neurosci Methods. 2010 May 15; 188(2):258-69.
    View in: PubMed
  12. Cheng H, Kastrup CJ, Ramanathan R, Siegwart DJ, Ma M, Bogatyrev SR, Xu Q, Whitehead KA, Langer R, Anderson DG. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. ACS Nano. 2010 Feb 23; 4(2):625-31.
    View in: PubMed
  13. Park H, Karajanagi S, Wolak K, Aanestad J, Daheron L, Kobler JB, Lopez-Guerra G, Heaton JT, Langer RS, Zeitels SM. Three-dimensional hydrogel model using adipose-derived stem cells for vocal fold augmentation. Tissue Eng Part A. 2010 Feb; 16(2):535-43.
    View in: PubMed
  14. Hoare T, Zurakowski D, Langer R, Kohane DS. Rheological blends for drug delivery. I. Characterization in vitro. J Biomed Mater Res A. 2010 Feb; 92(2):575-85.
    View in: PubMed
  15. Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR, Langer R, von Andrian U, Farokhzad OC. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine (Lond). 2010 Feb; 5(2):269-85.
    View in: PubMed
  16. Chan JM, Zhang L, Tong R, Ghosh D, Gao W, Liao G, Yuet KP, Gray D, Rhee JW, Cheng J, Golomb G, Libby P, Langer R, Farokhzad OC. Spatiotemporal controlled delivery of nanoparticles to injured vasculature. Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5):2213-8.
    View in: PubMed
  17. Love KT, Mahon KP, Levins CG, Whitehead KA, Querbes W, Dorkin JR, Qin J, Cantley W, Qin LL, Racie T, Frank-Kamenetsky M, Yip KN, Alvarez R, Sah DW, de Fougerolles A, Fitzgerald K, Koteliansky V, Akinc A, Langer R, Anderson DG. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5):1864-9.
    View in: PubMed
  18. Gao W, Xiao Z, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC. Progress in siRNA delivery using multifunctional nanoparticles. Methods Mol Biol. 2010; 629:53-67.
    View in: PubMed
  19. Alexis F, Pridgen EM, Langer R, Farokhzad OC. Nanoparticle technologies for cancer therapy. Handb Exp Pharmacol. 2010; (197):55-86.
    View in: PubMed
  20. Chan JM, Valencia PM, Zhang L, Langer R, Farokhzad OC. Polymeric nanoparticles for drug delivery. Methods Mol Biol. 2010; 624:163-75.
    View in: PubMed
  21. Gerecht S, Ferreira LS, Langer R. Vascular differentiation of human embryonic stem cells in bioactive hydrogel-based scaffolds. Methods Mol Biol. 2010; 584:333-54.
    View in: PubMed
  22. Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS. Photo-targeted nanoparticles. Nano Lett. 2010 Jan; 10(1):250-4.
    View in: PubMed
  23. Bettinger CJ, Bruggeman JP, Borenstein JT, Langer R. In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers. J Biomed Mater Res A. 2009 Dec 15; 91(4):1077-88.
    View in: PubMed
  24. Pritchard CD, Arnér KM, Neal RA, Neeley WL, Bojo P, Bachelder E, Holz J, Watson N, Botchwey EA, Langer RS, Ghosh FK. The use of surface modified poly(glycerol-co-sebacic acid) in retinal transplantation. Biomaterials. 2010 Mar; 31(8):2153-62.
    View in: PubMed
  25. Hudson SP, Langer R, Fink GR, Kohane DS. Injectable in situ cross-linking hydrogels for local antifungal therapy. Biomaterials. 2010 Feb; 31(6):1444-52.
    View in: PubMed
  26. George PM, Saigal R, Lawlor MW, Moore MJ, LaVan DA, Marini RP, Selig M, Makhni M, Burdick JA, Langer R, Kohane DS. Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2009 Nov; 91(2):519-27.
    View in: PubMed
  27. Harris TJ, Green JJ, Fung PW, Langer R, Anderson DG, Bhatia SN. Tissue-specific gene delivery via nanoparticle coating. Biomaterials. 2010 Feb; 31(5):998-1006.
    View in: PubMed
  28. Stone GW, Barzee S, Snarsky V, Santucci C, Tran B, Langer R, Zugates GT, Anderson DG, Kornbluth RS. Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma. PLoS One. 2009; 4(10):e7334.
    View in: PubMed
  29. Hook AL, Anderson DG, Langer R, Williams P, Davies MC, Alexander MR. High throughput methods applied in biomaterial development and discovery. Biomaterials. 2010 Jan; 31(2):187-98.
    View in: PubMed
  30. Yang F, Cho SW, Son SM, Bogatyrev SR, Singh D, Green JJ, Mei Y, Park S, Bhang SH, Kim BS, Langer R, Anderson DG. Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3317-22.
    View in: PubMed
  31. Dang TT, Xu Q, Bratlie KM, O'Sullivan ES, Chen XY, Langer R, Anderson DG. Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules. Biomaterials. 2009 Dec; 30(36):6896-902.
    View in: PubMed
  32. Hoare T, Santamaria J, Goya GF, Irusta S, Lin D, Lau S, Padera R, Langer R, Kohane DS. A magnetically triggered composite membrane for on-demand drug delivery. Nano Lett. 2009 Oct; 9(10):3651-7.
    View in: PubMed
  33. Guerrini M, Zhang Z, Shriver Z, Naggi A, Masuko S, Langer R, Casu B, Linhardt RJ, Torri G, Sasisekharan R. Orthogonal analytical approaches to detect potential contaminants in heparin. Proc Natl Acad Sci U S A. 2009 Oct 6; 106(40):16956-61.
    View in: PubMed
  34. Huang YH, Zugates GT, Peng W, Holtz D, Dunton C, Green JJ, Hossain N, Chernick MR, Padera RF, Langer R, Anderson DG, Sawicki JA. Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice. Cancer Res. 2009 Aug 1; 69(15):6184-91.
    View in: PubMed
  35. Bhang SH, Cho SW, Lim JM, Kang JM, Lee TJ, Yang HS, Song YS, Park MH, Kim HS, Yoo KJ, Jang Y, Langer R, Anderson DG, Kim BS. Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs. Stem Cells. 2009 Aug; 27(8):1976-86.
    View in: PubMed
  36. Nguyen DN, Chen SC, Lu J, Goldberg M, Kim P, Sprague A, Novobrantseva T, Sherman J, Shulga-Morskaya S, de Fougerolles A, Chen J, Langer R, Anderson DG. Drug delivery-mediated control of RNA immunostimulation. Mol Ther. 2009 Sep; 17(9):1555-62.
    View in: PubMed
  37. Xu Q, Hashimoto M, Dang TT, Hoare T, Kohane DS, Whitesides GM, Langer R, Anderson DG. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009 Jul; 5(13):1575-81.
    View in: PubMed
  38. Yang F, Mei Y, Langer R, Anderson DG. High throughput optimization of stem cell microenvironments. Comb Chem High Throughput Screen. 2009 Jul; 12(6):554-61.
    View in: PubMed
  39. Nguyen DN, Kim P, Martínez-Sobrido L, Beitzel B, García-Sastre A, Langer R, Anderson DG. A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery. Biotechnol Bioeng. 2009 Jul 1; 103(4):664-75.
    View in: PubMed
  40. Kraehenbuehl TP, Ferreira LS, Zammaretti P, Hubbell JA, Langer R. Cell-responsive hydrogel for encapsulation of vascular cells. Biomaterials. 2009 Sep; 30(26):4318-24.
    View in: PubMed
  41. Bettinger CJ, Kulig KM, Vacanti JP, Langer R, Borenstein JT. Nanofabricated collagen-inspired synthetic elastomers for primary rat hepatocyte culture. Tissue Eng Part A. 2009 Jun; 15(6):1321-9.
    View in: PubMed
  42. Lee JS, Green JJ, Love KT, Sunshine J, Langer R, Anderson DG. Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett. 2009 Jun; 9(6):2402-6.
    View in: PubMed
  43. Yu D, Neeley WL, Pritchard CD, Slotkin JR, Woodard EJ, Langer R, Teng YD. Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer. Stem Cells. 2009 May; 27(5):1212-22.
    View in: PubMed
  44. Lu JJ, Langer R, Chen J. A novel mechanism is involved in cationic lipid-mediated functional siRNA delivery. Mol Pharm. 2009 May-Jun; 6(3):763-71.
    View in: PubMed
  45. Khademhosseini A, Vacanti JP, Langer R. Progress in tissue engineering. Sci Am. 2009 May; 300(5):64-71.
    View in: PubMed
  46. Langer R. A conversation with Robert Langer: pioneering biomedical scientist and engineer. Interview by Paul S. Weiss. ACS Nano. 2009 Apr 28; 3(4):756-61.
    View in: PubMed
  47. Daniel KD, Kim GY, Vassiliou CC, Galindo M, Guimaraes AR, Weissleder R, Charest A, Langer R, Cima MJ. Implantable diagnostic device for cancer monitoring. Biosens Bioelectron. 2009 Jul 15; 24(11):3252-7.
    View in: PubMed
  48. Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7125-30.
    View in: PubMed
  49. Redenti S, Neeley WL, Rompani S, Saigal S, Yang J, Klassen H, Langer R, Young MJ. Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation. Biomaterials. 2009 Jul; 30(20):3405-14.
    View in: PubMed
  50. Bettinger CJ, Bruggeman JP, Misra A, Borenstein JT, Langer R. Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering. Biomaterials. 2009 Jun; 30(17):3050-7.
    View in: PubMed
  51. Shapiro MG, Szablowski JO, Langer R, Jasanoff A. Protein nanoparticles engineered to sense kinase activity in MRI. J Am Chem Soc. 2009 Feb 25; 131(7):2484-6.
    View in: PubMed
  52. Whitehead KA, Langer R, Anderson DG. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov. 2009 Feb; 8(2):129-38.
    View in: PubMed
  53. Salvador-Morales C, Gao W, Ghatalia P, Murshed F, Aizu W, Langer R, Farokhzad OC. Multifunctional nanoparticles for prostate cancer therapy. Expert Rev Anticancer Ther. 2009 Feb; 9(2):211-21.
    View in: PubMed
  54. Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano. 2009 Jan 27; 3(1):16-20.
    View in: PubMed
  55. Salvador-Morales C, Zhang L, Langer R, Farokhzad OC. Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups. Biomaterials. 2009 Apr; 30(12):2231-40.
    View in: PubMed
  56. Ciolino JB, Hoare TR, Iwata NG, Behlau I, Dohlman CH, Langer R, Kohane DS. A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3346-52.
    View in: PubMed
  57. Bettinger CJ, Langer R, Borenstein JT. Engineering substrate topography at the micro- and nanoscale to control cell function. Angew Chem Int Ed Engl. 2009; 48(30):5406-15.
    View in: PubMed
  58. Green JJ, Zugates GT, Langer R, Anderson DG. Poly(beta-amino esters): procedures for synthesis and gene delivery. Methods Mol Biol. 2009; 480:53-63.
    View in: PubMed
  59. Gu F, Langer R, Farokhzad OC. Formulation/preparation of functionalized nanoparticles for in vivo targeted drug delivery. Methods Mol Biol. 2009; 544:589-98.
    View in: PubMed
  60. Chan JM, Zhang L, Yuet KP, Liao G, Rhee JW, Langer R, Farokhzad OC. PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery. Biomaterials. 2009 Mar; 30(8):1627-34.
    View in: PubMed
  61. Blossom DB, Kallen AJ, Patel PR, Elward A, Robinson L, Gao G, Langer R, Perkins KM, Jaeger JL, Kurkjian KM, Jones M, Schillie SF, Shehab N, Ketterer D, Venkataraman G, Kishimoto TK, Shriver Z, McMahon AW, Austen KF, Kozlowski S, Srinivasan A, Turabelidze G, Gould CV, Arduino MJ, Sasisekharan R. Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med. 2008 Dec 18; 359(25):2674-84.
    View in: PubMed
  62. Engelmayr GC, Cheng M, Bettinger CJ, Borenstein JT, Langer R, Freed LE. Accordion-like honeycombs for tissue engineering of cardiac anisotropy. Nat Mater. 2008 Dec; 7(12):1003-10.
    View in: PubMed
  63. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008 Nov; 26(11):1261-8.
    View in: PubMed
  64. Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ. Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17356-61.
    View in: PubMed
  65. Mei Y, Cannizzaro C, Park H, Xu Q, Bogatyrev SR, Yi K, Goldman N, Langer R, Anderson DG. Cell-compatible, multicomponent protein arrays with subcellular feature resolution. Small. 2008 Oct; 4(10):1600-4.
    View in: PubMed
  66. Kushner J, Blankschtein D, Langer R. Heterogeneity in skin treated with low-frequency ultrasound. J Pharm Sci. 2008 Oct; 97(10):4119-28.
    View in: PubMed
  67. Hudson SP, Padera RF, Langer R, Kohane DS. The biocompatibility of mesoporous silicates. Biomaterials. 2008 Oct; 29(30):4045-55.
    View in: PubMed
  68. Bruggeman JP, de Bruin BJ, Bettinger CJ, Langer R. Biodegradable poly(polyol sebacate) polymers. Biomaterials. 2008 Dec; 29(36):4726-35.
    View in: PubMed
  69. Radisic M, Park H, Martens TP, Salazar-Lazaro JE, Geng W, Wang Y, Langer R, Freed LE, Vunjak-Novakovic G. Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue. J Biomed Mater Res A. 2008 Sep; 86(3):713-24.
    View in: PubMed
  70. Wang AZ, Bagalkot V, Vasilliou CC, Gu F, Alexis F, Zhang L, Shaikh M, Yuet K, Cima MJ, Langer R, Kantoff PW, Bander NH, Jon S, Farokhzad OC. Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem. 2008 Sep; 3(9):1311-5.
    View in: PubMed
  71. Cho SW, Hartle L, Son SM, Yang F, Goldberg M, Xu Q, Langer R, Anderson DG. Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation. Biochem Biophys Res Commun. 2008 Nov 7; 376(1):158-63.
    View in: PubMed
  72. Green JJ, Zhou BY, Mitalipova MM, Beard C, Langer R, Jaenisch R, Anderson DG. Nanoparticles for gene transfer to human embryonic stem cell colonies. Nano Lett. 2008 Oct; 8(10):3126-30.
    View in: PubMed
  73. Ferreira L, Karp JM, Nobre L, Langer R. New opportunities: the use of nanotechnologies to manipulate and track stem cells. Cell Stem Cell. 2008 Aug 7; 3(2):136-46.
    View in: PubMed
  74. Zhang L, Chan JM, Gu FX, Rhee JW, Wang AZ, Radovic-Moreno AF, Alexis F, Langer R, Farokhzad OC. Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform. ACS Nano. 2008 Aug; 2(8):1696-702.
    View in: PubMed
  75. Park H, Williams R, Goldman N, Choe H, Kobler J, Lopez-Guerra G, Heaton JT, Langer R, Zeitels SM. Comparison of effects of 2 harvesting methods on fat autograft. Laryngoscope. 2008 Aug; 118(8):1493-9.
    View in: PubMed
  76. Karnik R, Gu F, Basto P, Cannizzaro C, Dean L, Kyei-Manu W, Langer R, Farokhzad OC. Microfluidic platform for controlled synthesis of polymeric nanoparticles. Nano Lett. 2008 Sep; 8(9):2906-12.
    View in: PubMed
  77. Adams DR, Toner M, Langer R. Microflow and crack formation patterns in drying sessile droplets of liposomes suspended in trehalose solutions. Langmuir. 2008 Aug 5; 24(15):7688-97.
    View in: PubMed
  78. Park H, Bhalla R, Saigal R, Radisic M, Watson N, Langer R, Vunjak-Novakovic G. Effects of electrical stimulation in C2C12 muscle constructs. J Tissue Eng Regen Med. 2008 Jul; 2(5):279-87.
    View in: PubMed
  79. Levy-Nissenbaum E, Radovic-Moreno AF, Wang AZ, Langer R, Farokhzad OC. Nanotechnology and aptamers: applications in drug delivery. Trends Biotechnol. 2008 Aug; 26(8):442-9.
    View in: PubMed
  80. Auguste DT, Furman K, Wong A, Fuller J, Armes SP, Deming TJ, Langer R. Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes. J Control Release. 2008 Sep 24; 130(3):266-74.
    View in: PubMed
  81. Wright D, Rajalingam B, Karp JM, Selvarasah S, Ling Y, Yeh J, Langer R, Dokmeci MR, Khademhosseini A. Reusable, reversibly sealable parylene membranes for cell and protein patterning. J Biomed Mater Res A. 2008 May; 85(2):530-8.
    View in: PubMed
  82. Kohane DS, Langer R. Polymeric biomaterials in tissue engineering. Pediatr Res. 2008 May; 63(5):487-91.
    View in: PubMed
  83. Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, Bacallado SA, Nguyen DN, Fuller J, Alvarez R, Borodovsky A, Borland T, Constien R, de Fougerolles A, Dorkin JR, Narayanannair Jayaprakash K, Jayaraman M, John M, Koteliansky V, Manoharan M, Nechev L, Qin J, Racie T, Raitcheva D, Rajeev KG, Sah DW, Soutschek J, Toudjarska I, Vornlocher HP, Zimmermann TS, Langer R, Anderson DG. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol. 2008 May; 26(5):561-9.
    View in: PubMed
  84. Kishimoto TK, Viswanathan K, Ganguly T, Elankumaran S, Smith S, Pelzer K, Lansing JC, Sriranganathan N, Zhao G, Galcheva-Gargova Z, Al-Hakim A, Bailey GS, Fraser B, Roy S, Rogers-Cotrone T, Buhse L, Whary M, Fox J, Nasr M, Dal Pan GJ, Shriver Z, Langer RS, Venkataraman G, Austen KF, Woodcock J, Sasisekharan R. Contaminated heparin associated with adverse clinical events and activation of the contact system. N Engl J Med. 2008 Jun 5; 358(23):2457-67.
    View in: PubMed
  85. Guerrini M, Beccati D, Shriver Z, Naggi A, Viswanathan K, Bisio A, Capila I, Lansing JC, Guglieri S, Fraser B, Al-Hakim A, Gunay NS, Zhang Z, Robinson L, Buhse L, Nasr M, Woodcock J, Langer R, Venkataraman G, Linhardt RJ, Casu B, Torri G, Sasisekharan R. Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol. 2008 Jun; 26(6):669-75.
    View in: PubMed
  86. Nguyen DN, Raghavan SS, Tashima LM, Lin EC, Fredette SJ, Langer RS, Wang C. Enhancement of poly(orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine). Biomaterials. 2008 Jun; 29(18):2783-93.
    View in: PubMed
  87. Parsa S, Wang Y, Fuller J, Langer R, Pfeifer BA. A comparison between polymeric microsphere and bacterial vectors for macrophage P388D1 gene delivery. Pharm Res. 2008 May; 25(5):1202-8.
    View in: PubMed
  88. Karnik R, Hong S, Zhang H, Mei Y, Anderson DG, Karp JM, Langer R. Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors. Nano Lett. 2008 Apr; 8(4):1153-8.
    View in: PubMed
  89. Bettinger CJ, Bruggeman JP, Borenstein JT, Langer RS. Amino alcohol-based degradable poly(ester amide) elastomers. Biomaterials. 2008 May; 29(15):2315-25.
    View in: PubMed
  90. Brito L, Little S, Langer R, Amiji M. Poly(beta-amino ester) and cationic phospholipid-based lipopolyplexes for gene delivery and transfection in human aortic endothelial and smooth muscle cells. Biomacromolecules. 2008 Apr; 9(4):1179-87.
    View in: PubMed
  91. Mahdavi A, Ferreira L, Sundback C, Nichol JW, Chan EP, Carter DJ, Bettinger CJ, Patanavanich S, Chignozha L, Ben-Joseph E, Galakatos A, Pryor H, Pomerantseva I, Masiakos PT, Faquin W, Zumbuehl A, Hong S, Borenstein J, Vacanti J, Langer R, Karp JM. A biodegradable and biocompatible gecko-inspired tissue adhesive. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2307-12.
    View in: PubMed
  92. Gu F, Zhang L, Teply BA, Mann N, Wang A, Radovic-Moreno AF, Langer R, Farokhzad OC. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2586-91.
    View in: PubMed
  93. Kushner J, Blankschtein D, Langer R. Evaluation of hydrophilic permeant transport parameters in the localized and non-localized transport regions of skin treated simultaneously with low-frequency ultrasound and sodium lauryl sulfate. J Pharm Sci. 2008 Feb; 97(2):906-18.
    View in: PubMed
  94. Chau Y, Luo Y, Cheung AC, Nagai Y, Zhang S, Kobler JB, Zeitels SM, Langer R. Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds. Biomaterials. 2008 Apr; 29(11):1713-9.
    View in: PubMed
  95. Wood KC, Azarin SM, Arap W, Pasqualini R, Langer R, Hammond PT. Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide. Bioconjug Chem. 2008 Feb; 19(2):403-5.
    View in: PubMed
  96. Sawicki JA, Anderson DG, Langer R. Nanoparticle delivery of suicide DNA for epithelial ovarian cancer therapy. Adv Exp Med Biol. 2008; 622:209-19.
    View in: PubMed
  97. Alexis F, Rhee JW, Richie JP, Radovic-Moreno AF, Langer R, Farokhzad OC. New frontiers in nanotechnology for cancer treatment. Urol Oncol. 2008 Jan-Feb; 26(1):74-85.
    View in: PubMed
  98. Fuller JE, Zugates GT, Ferreira LS, Ow HS, Nguyen NN, Wiesner UB, Langer RS. Intracellular delivery of core-shell fluorescent silica nanoparticles. Biomaterials. 2008 Apr; 29(10):1526-32.
    View in: PubMed
  99. Teply BA, Tong R, Jeong SY, Luther G, Sherifi I, Yim CH, Khademhosseini A, Farokhzad OC, Langer RS, Cheng J. The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules. Biomaterials. 2008 Mar; 29(9):1216-23.
    View in: PubMed
  100. Kushner J, Blankschtein D, Langer R. Evaluation of the porosity, the tortuosity, and the hindrance factor for the transdermal delivery of hydrophilic permeants in the context of the aqueous pore pathway hypothesis using dual-radiolabeled permeability experiments. J Pharm Sci. 2007 Dec; 96(12):3263-82.
    View in: PubMed
  101. Kushner J, Deen W, Blankschtein D, Langer R. First-principles, structure-based transdermal transport model to evaluate lipid partition and diffusion coefficients of hydrophobic permeants solely from stratum corneum permeation experiments. J Pharm Sci. 2007 Dec; 96(12):3236-51.
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  108. Hong S, Lee D, Zhang H, Zhang JQ, Resvick JN, Khademhosseini A, King MR, Langer R, Karp JM. Covalent immobilization of p-selectin enhances cell rolling. Langmuir. 2007 Nov 20; 23(24):12261-8.
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  112. Kim GY, Josephson L, Langer R, Cima MJ. Magnetic relaxation switch detection of human chorionic gonadotrophin. Bioconjug Chem. 2007 Nov-Dec; 18(6):2024-8.
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  113. Jiang C, Moore MJ, Zhang X, Klassen H, Langer R, Young M. Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma. Mol Vis. 2007; 13:1783-92.
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  115. Townsend SA, Evrony GD, Gu FX, Schulz MP, Brown RH, Langer R. Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons. Biomaterials. 2007 Dec; 28(34):5176-84.
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  116. Evgenov OV, Kohane DS, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 1; 176(11):1138-45.
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  117. Zhang L, Radovic-Moreno AF, Alexis F, Gu FX, Basto PA, Bagalkot V, Jon S, Langer RS, Farokhzad OC. Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates. ChemMedChem. 2007 Sep; 2(9):1268-71.
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  118. Nijst CL, Bruggeman JP, Karp JM, Ferreira L, Zumbuehl A, Bettinger CJ, Langer R. Synthesis and characterization of photocurable elastomers from poly(glycerol-co-sebacate). Biomacromolecules. 2007 Oct; 8(10):3067-73.
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  120. Kim GY, Tyler BM, Tupper MM, Karp JM, Langer RS, Brem H, Cima MJ. Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model. J Control Release. 2007 Nov 6; 123(2):172-8.
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  122. Park H, Cannizzaro C, Vunjak-Novakovic G, Langer R, Vacanti CA, Farokhzad OC. Nanofabrication and microfabrication of functional materials for tissue engineering. Tissue Eng. 2007 Aug; 13(8):1867-77.
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  124. Daniel KD, Kim GY, Vassiliou CC, Jalali-Yazdi F, Langer R, Cima MJ. Multi-reservoir device for detecting a soluble cancer biomarker. Lab Chip. 2007 Oct; 7(10):1288-93.
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  125. Gerecht S, Burdick JA, Ferreira LS, Townsend SA, Langer R, Vunjak-Novakovic G. Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2007 Jul 3; 104(27):11298-303.
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  127. Ferreira LS, Gerecht S, Shieh HF, Watson N, Rupnick MA, Dallabrida SM, Vunjak-Novakovic G, Langer R. Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo. Circ Res. 2007 Aug 3; 101(3):286-94.
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  128. Kushner J, Kim D, So PT, Blankschtein D, Langer RS. Dual-channel two-photon microscopy study of transdermal transport in skin treated with low-frequency ultrasound and a chemical enhancer. J Invest Dermatol. 2007 Dec; 127(12):2832-46.
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  129. Ng TF, Lavik E, Keino H, Taylor AW, Langer RS, Young MJ. Creating an immune-privileged site using retinal progenitor cells and biodegradable polymers. Stem Cells. 2007 Jun; 25(6):1552-9.
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  130. Figallo E, Cannizzaro C, Gerecht S, Burdick JA, Langer R, Elvassore N, Vunjak-Novakovic G. Micro-bioreactor array for controlling cellular microenvironments. Lab Chip. 2007 Jun; 7(6):710-9.
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  131. Yeo Y, Bellas E, Highley CB, Langer R, Kohane DS. Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model. Biomaterials. 2007 Sep; 28(25):3704-13.
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  136. Choleris E, Little SR, Mong JA, Puram SV, Langer R, Pfaff DW. Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4670-5.
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  137. Loose CR, Langer RS, Stephanopoulos GN. Optimization of protein fusion partner length for maximizing in vitro translation of peptides. Biotechnol Prog. 2007 Mar-Apr; 23(2):444-51.
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  139. Goldberg M, Langer R, Jia X. Nanostructured materials for applications in drug delivery and tissue engineering. J Biomater Sci Polym Ed. 2007; 18(3):241-68.
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  140. Bagalkot V, Farokhzad OC, Langer R, Jon S. An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed Engl. 2006 Dec 11; 45(48):8149-52.
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  141. Jia X, Yeo Y, Clifton RJ, Jiao T, Kohane DS, Kobler JB, Zeitels SM, Langer R. Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules. 2006 Dec; 7(12):3336-44.
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  144. Watanabe W, Thomas M, Clarke R, Klibanov AM, Langer R, Katstra J, Fuller GG, Griel LC, Fiegel J, Edwards D. Why inhaling salt water changes what we exhale. J Colloid Interface Sci. 2007 Mar 1; 307(1):71-8.
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  145. Teng YD, Liao WL, Choi H, Konya D, Sabharwal S, Langer R, Sidman RL, Snyder EY, Frontera WR. Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells. Regen Med. 2006 Nov; 1(6):763-76.
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  150. Yeo Y, Burdick JA, Highley CB, Marini R, Langer R, Kohane DS. Peritoneal application of chitosan and UV-cross-linkable chitosan. J Biomed Mater Res A. 2006 Sep 15; 78(4):668-75.
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  152. Farokhzad OC, Dimitrakov JD, Karp JM, Khademhosseini A, Freeman MR, Langer R. Drug delivery systems in urology--getting "smarter". Urology. 2006 Sep; 68(3):463-9.
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  153. Khademhosseini A, Ferreira L, Blumling J, Yeh J, Karp JM, Fukuda J, Langer R. Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates. Biomaterials. 2006 Dec; 27(36):5968-77.
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  154. Radisic M, Park H, Chen F, Salazar-Lazzaro JE, Wang Y, Dennis R, Langer R, Freed LE, Vunjak-Novakovic G. Biomimetic approach to cardiac tissue engineering: oxygen carriers and channeled scaffolds. Tissue Eng. 2006 Aug; 12(8):2077-91.
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  155. Berry D, Lynn DM, Berry E, Sasisekharan R, Langer R. Heparin localization and fine structure regulate Burkitt's lymphoma growth. Biochem Biophys Res Commun. 2006 Sep 29; 348(3):850-6.
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  158. Meinel L, Hofmann S, Betz O, Fajardo R, Merkle HP, Langer R, Evans CH, Vunjak-Novakovic G, Kaplan DL. Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: comparison of adenovirus mediated gene transfer and protein delivery of BMP-2. Biomaterials. 2006 Oct; 27(28):4993-5002.
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  160. Suh KY, Khademhosseini A, Jon S, Langer R. Direct confinement of individual viruses within polyethylene glycol (PEG) nanowells. Nano Lett. 2006 Jun; 6(6):1196-201.
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  164. Farokhzad OC, Karp JM, Langer R. Nanoparticle-aptamer bioconjugates for cancer targeting. Expert Opin Drug Deliv. 2006 May; 3(3):311-24.
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  166. Chau Y, Padera RF, Dang NM, Langer R. Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models. Int J Cancer. 2006 Mar 15; 118(6):1519-26.
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  180. Colombo G, Padera R, Langer R, Kohane DS. Prolonged duration local anesthesia with lipid-protein-sugar particles containing bupivacaine and dexamethasone. J Biomed Mater Res A. 2005 Nov 1; 75(2):458-64.
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  183. Little SR, Lynn DM, Puram SV, Langer R. Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery. J Control Release. 2005 Oct 20; 107(3):449-62.
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  188. Yeo Y, Bellas E, Firestone W, Langer R, Kohane DS. Complex coacervates for thermally sensitive controlled release of flavor compounds. J Agric Food Chem. 2005 Sep 21; 53(19):7518-25.
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  189. Pfeifer BA, Burdick JA, Little SR, Langer R. Poly(ester-anhydride):poly(beta-amino ester) micro- and nanospheres: DNA encapsulation and cellular transfection. Int J Pharm. 2005 Nov 4; 304(1-2):210-9.
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  191. Meinel L, Fajardo R, Hofmann S, Langer R, Chen J, Snyder B, Vunjak-Novakovic G, Kaplan D. Silk implants for the healing of critical size bone defects. Bone. 2005 Nov; 37(5):688-98.
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  192. Sundback CA, Shyu JY, Wang Y, Faquin WC, Langer RS, Vacanti JP, Hadlock TA. Biocompatibility analysis of poly(glycerol sebacate) as a nerve guide material. Biomaterials. 2005 Sep; 26(27):5454-64.
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  198. Levenberg S, Rouwkema J, Macdonald M, Garfein ES, Kohane DS, Darland DC, Marini R, van Blitterswijk CA, Mulligan RC, D'Amore PA, Langer R. Engineering vascularized skeletal muscle tissue. Nat Biotechnol. 2005 Jul; 23(7):879-84.
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  199. George PM, Lyckman AW, LaVan DA, Hegde A, Leung Y, Avasare R, Testa C, Alexander PM, Langer R, Sur M. Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics. Biomaterials. 2005 Jun; 26(17):3511-9.
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  202. Grayson AC, Cima MJ, Langer R. Size and temperature effects on poly(lactic-co-glycolic acid) degradation and microreservoir device performance. Biomaterials. 2005 May; 26(14):2137-45.
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  203. Lee PJ, Langer R, Shastri VP. Role of n-methyl pyrrolidone in the enhancement of aqueous phase transdermal transport. J Pharm Sci. 2005 Apr; 94(4):912-7.
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  205. Levenberg S, Burdick JA, Kraehenbuehl T, Langer R. Neurotrophin-induced differentiation of human embryonic stem cells on three-dimensional polymeric scaffolds. Tissue Eng. 2005 Mar-Apr; 11(3-4):506-12.
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  206. Suh KY, Yang JM, Khademhosseini A, Berry D, Tran TN, Park H, Langer R. Characterization of chemisorbed hyaluronic acid directly immobilized on solid substrates. J Biomed Mater Res B Appl Biomater. 2005 Feb 15; 72(2):292-8.
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  207. LaVan DA, Padera RF, Friedmann TA, Sullivan JP, Langer R, Kohane DS. In vivo evaluation of tetrahedral amorphous carbon. Biomaterials. 2005 Feb; 26(5):465-73.
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  209. Fidkowski C, Kaazempur-Mofrad MR, Borenstein J, Vacanti JP, Langer R, Wang Y. Endothelialized microvasculature based on a biodegradable elastomer. Tissue Eng. 2005 Jan-Feb; 11(1-2):302-9.
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  210. Burdick JA, Chung C, Jia X, Randolph MA, Langer R. Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules. 2005 Jan-Feb; 6(1):386-91.
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  211. Little SR, Langer R. Nonviral delivery of cancer genetic vaccines. Adv Biochem Eng Biotechnol. 2005; 99:93-118.
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  212. Meinel L, Hofmann S, Karageorgiou V, Kirker-Head C, McCool J, Gronowicz G, Zichner L, Langer R, Vunjak-Novakovic G, Kaplan DL. The inflammatory responses to silk films in vitro and in vivo. Biomaterials. 2005 Jan; 26(2):147-55.
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  213. Pfeifer BA, Burdick JA, Langer R. Formulation and surface modification of poly(ester-anhydride) micro- and nanospheres. Biomaterials. 2005 Jan; 26(2):117-24.
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  214. Radisic M, Park H, Shing H, Consi T, Schoen FJ, Langer R, Freed LE, Vunjak-Novakovic G. Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18129-34.
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  215. Shawgo RS, Voskerician G, Duc HL, Li Y, Lynn A, MacEwan M, Langer R, Anderson JM, Cima MJ. Repeated in vivo electrochemical activation and the biological effects of microelectromechanical systems drug delivery device. J Biomed Mater Res A. 2004 Dec 15; 71(4):559-68.
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  216. Li Y, Shawgo RS, Tyler B, Henderson PT, Vogel JS, Rosenberg A, Storm PB, Langer R, Brem H, Cima MJ. In vivo release from a drug delivery MEMS device. J Control Release. 2004 Nov 24; 100(2):211-9.
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  217. Radisic M, Deen W, Langer R, Vunjak-Novakovic G. Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1278-89.
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  218. Meinel L, Hofmann S, Karageorgiou V, Zichner L, Langer R, Kaplan D, Vunjak-Novakovic G. Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds. Biotechnol Bioeng. 2004 Nov 5; 88(3):379-91.
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  219. Anderson DG, Peng W, Akinc A, Hossain N, Kohn A, Padera R, Langer R, Sawicki JA. A polymer library approach to suicide gene therapy for cancer. Proc Natl Acad Sci U S A. 2004 Nov 9; 101(45):16028-33.
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  220. Farokhzad OC, Jon S, Khademhosseini A, Tran TN, Lavan DA, Langer R. Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res. 2004 Nov 1; 64(21):7668-72.
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  221. Kushner J, Blankschtein D, Langer R. Experimental demonstration of the existence of highly permeable localized transport regions in low-frequency sonophoresis. J Pharm Sci. 2004 Nov; 93(11):2733-45.
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  222. Meinel L, Karageorgiou V, Hofmann S, Fajardo R, Snyder B, Li C, Zichner L, Langer R, Vunjak-Novakovic G, Kaplan DL. Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds. J Biomed Mater Res A. 2004 Oct 1; 71(1):25-34.
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  223. Anderson DG, Burdick JA, Langer R. Materials science. Smart biomaterials. Science. 2004 Sep 24; 305(5692):1923-4.
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  224. Chen PC, Park YJ, Chang LC, Kohane DS, Bartlett RH, Langer R, Yang VC. Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization. J Biomed Mater Res A. 2004 Sep 1; 70(3):412-9.
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  225. Chen PC, Kohane DS, Park YJ, Bartlett RH, Langer R, Yang VC. Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects. J Biomed Mater Res A. 2004 Sep 1; 70(3):459-66.
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  226. Stevens MM, Marini RP, Martin I, Langer R, Prasad Shastri V. FGF-2 enhances TGF-beta1-induced periosteal chondrogenesis. J Orthop Res. 2004 Sep; 22(5):1114-9.
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  227. Suh KY, Khademhosseini A, Yoo PJ, Langer R. Patterning and separating infected bacteria using host-parasite and virus-antibody interactions. Biomed Microdevices. 2004 Sep; 6(3):223-9.
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  228. Haining WN, Anderson DG, Little SR, von Bergwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS, von Berwelt-Baildon MS. pH-triggered microparticles for peptide vaccination. J Immunol. 2004 Aug 15; 173(4):2578-85.
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  229. Yue IC, Poff J, Cortés ME, Sinisterra RD, Faris CB, Hildgen P, Langer R, Shastri VP. A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease. Biomaterials. 2004 Aug; 25(17):3743-50.
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  230. Khademhosseini A, Suh KY, Yang JM, Eng G, Yeh J, Levenberg S, Langer R. Layer-by-layer deposition of hyaluronic acid and poly-L-lysine for patterned cell co-cultures. Biomaterials. 2004 Aug; 25(17):3583-92.
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  231. Jia X, Colombo G, Padera R, Langer R, Kohane DS. Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid. Biomaterials. 2004 Aug; 25(19):4797-804.
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  232. Khademhosseini A, Yeh J, Jon S, Eng G, Suh KY, Burdick JA, Langer R. Molded polyethylene glycol microstructures for capturing cells within microfluidic channels. Lab Chip. 2004 Oct; 4(5):425-30.
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  233. Suh KY, Khademhosseini A, Eng G, Langer R. Single nanocrystal arrays on patterned poly(ethylene glycol) copolymer microstructures using selective wetting and drying. Langmuir. 2004 Jul 20; 20(15):6080-4.
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  234. Marini RP, Stevens MM, Langer R, Shastri VP. Hydraulic elevation of the periosteum: a novel technique for periosteal harvest. J Invest Surg. 2004 Jul-Aug; 17(4):229-33.
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  235. Langer RS. An audience with... Robert S. Langer [interviewed by Kenneth J. Germeshausen]. Nat Rev Drug Discov. 2004 Jul; 3(7):546.
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  236. Khademhosseini A, Suh KY, Jon S, Eng G, Yeh J, Chen GJ, Langer R. A soft lithographic approach to fabricate patterned microfluidic channels. Anal Chem. 2004 Jul 1; 76(13):3675-81.
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  237. Qi Y, Zhao G, Liu D, Shriver Z, Sundaram M, Sengupta S, Venkataraman G, Langer R, Sasisekharan R. Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9867-72.
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  238. Burdick JA, Khademhosseini A, Langer R. Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir. 2004 Jun 22; 20(13):5153-6.
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  239. Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen J, Eisen HN, Langer R. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9534-9.
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  240. Anderson DG, Levenberg S, Langer R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol. 2004 Jul; 22(7):863-6.
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  241. Richards Grayson AC, Cima MJ, Langer R. Molecular release from a polymeric microreservoir device: Influence of chemistry, polymer swelling, and loading on device performance. J Biomed Mater Res A. 2004 Jun 1; 69(3):502-12.
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  242. Thomas TT, Kohane DS, Wang A, Langer R. Microparticulate formulations for the controlled release of interleukin-2. J Pharm Sci. 2004 May; 93(5):1100-9.
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  243. Voskerician G, Shawgo RS, Hiltner PA, Anderson JM, Cima MJ, Langer R. In vivo inflammatory and wound healing effects of gold electrode voltammetry for MEMS micro-reservoir drug delivery device. IEEE Trans Biomed Eng. 2004 Apr; 51(4):627-35.
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  244. Langer R, Tirrell DA. Designing materials for biology and medicine. Nature. 2004 Apr 1; 428(6982):487-92.
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  245. Berry D, Lynn DM, Sasisekharan R, Langer R. Poly(beta-amino ester)s promote cellular uptake of heparin and cancer cell death. Chem Biol. 2004 Apr; 11(4):487-98.
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  246. Langer R. Transdermal drug delivery: past progress, current status, and future prospects. Adv Drug Deliv Rev. 2004 Mar 27; 56(5):557-8.
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  247. Colombo G, Langer R, Kohane DS. Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J Biomed Mater Res A. 2004 Mar 15; 68(4):651-9.
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  248. Wang C, Ge Q, Ting D, Nguyen D, Shen HR, Chen J, Eisen HN, Heller J, Langer R, Putnam D. Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines. Nat Mater. 2004 Mar; 3(3):190-6.
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  249. Stevens MM, Qanadilo HF, Langer R, Prasad Shastri V. A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering. Biomaterials. 2004 Feb; 25(5):887-94.
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  250. Suh KY, Seong J, Khademhosseini A, Laibinis PE, Langer R. A simple soft lithographic route to fabrication of poly(ethylene glycol) microstructures for protein and cell patterning. Biomaterials. 2004 Feb; 25(3):557-63.
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  251. Shastri VP, Padera RF, Tarcha P, Langer R. A preliminary report on the biocompatibility of photopolymerizable semi-interpenetrating anhydride networks. Biomaterials. 2004 Feb; 25(4):715-21.
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  252. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov. 2004 Feb; 3(2):115-24.
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  253. Meinel L, Karageorgiou V, Fajardo R, Snyder B, Shinde-Patil V, Zichner L, Kaplan D, Langer R, Vunjak-Novakovic G. Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Ann Biomed Eng. 2004 Jan; 32(1):112-22.
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  254. Pouliot R, Azhari R, Qanadilo HF, Mahmood TA, Triantafyllou MS, Langer R. Tissue engineering of fish skin: behavior of fish cells on poly(ethylene glycol terephthalate)/poly(butylene terephthalate) copolymers in relation to the composition of the polymer substrate as an initial step in constructing a robotic/living tissue hybrid. Tissue Eng. 2004 Jan-Feb; 10(1-2):7-21.
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  255. Grayson AC, Voskerician G, Lynn A, Anderson JM, Cima MJ, Langer R. Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip. J Biomater Sci Polym Ed. 2004; 15(10):1281-304.
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  256. Levenberg S, Langer R. Advances in tissue engineering. Curr Top Dev Biol. 2004; 61:113-34.
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  257. Grovender EA, Kellogg B, Singh J, Blom D, Ploegh H, Wittrup KD, Langer RS, Ameer GA. Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin. Kidney Int. 2004 Jan; 65(1):310-22.
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  258. Yu B, Kim KH, So PT, Blankschtein D, Langer R. Evaluation of fluorescent probe surface intensities as an indicator of transdermal permeant distributions using wide-area two-photon fluorescence microscopy. J Pharm Sci. 2003 Dec; 92(12):2354-65.
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  259. Lee H, Cusick RA, Utsunomiya H, Ma PX, Langer R, Vacanti JP. Effect of implantation site on hepatocytes heterotopically transplanted on biodegradable polymer scaffolds. Tissue Eng. 2003 Dec; 9(6):1227-32.
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  260. Putnam D, Zelikin AN, Izumrudov VA, Langer R. Polyhistidine-PEG:DNA nanocomposites for gene delivery. Biomaterials. 2003 Nov; 24(24):4425-33.
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  261. Richards Grayson AC, Choi IS, Tyler BM, Wang PP, Brem H, Cima MJ, Langer R. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat Mater. 2003 Nov; 2(11):767-72.
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  262. Moses MA, Brem H, Langer R. Advancing the field of drug delivery: taking aim at cancer. Cancer Cell. 2003 Nov; 4(5):337-41.
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  263. Jon S, Anderson DG, Langer R. Degradable poly(amino alcohol esters) as potential DNA vectors with low cytotoxicity. Biomacromolecules. 2003 Nov-Dec; 4(6):1759-62.
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  264. Levenberg S, Huang NF, Lavik E, Rogers AB, Itskovitz-Eldor J, Langer R. Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12741-6.
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  265. Radisic M, Yang L, Boublik J, Cohen RJ, Langer R, Freed LE, Vunjak-Novakovic G. Medium perfusion enables engineering of compact and contractile cardiac tissue. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H507-16.
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  266. LaVan DA, McGuire T, Langer R. Small-scale systems for in vivo drug delivery. Nat Biotechnol. 2003 Oct; 21(10):1184-91.
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  267. Kohane DS, Anderson DG, Yu C, Langer R. pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharm Res. 2003 Oct; 20(10):1533-8.
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  268. Akinc A, Anderson DG, Lynn DM, Langer R. Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery. Bioconjug Chem. 2003 Sep-Oct; 14(5):979-88.
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  269. Shastri VP, Hildgen P, Langer R. In situ pore formation in a polymer matrix by differential polymer degradation. Biomaterials. 2003 Aug; 24(18):3133-7.
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  270. Fu K, Harrell R, Zinski K, Um C, Jaklenec A, Frazier J, Lotan N, Burke P, Klibanov AM, Langer R. A potential approach for decreasing the burst effect of protein from PLGA microspheres. J Pharm Sci. 2003 Aug; 92(8):1582-91.
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  271. Anderson DG, Lynn DM, Langer R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl. 2003 Jul 14; 42(27):3153-8.
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  272. Wang Y, Kim YM, Langer R. In vivo degradation characteristics of poly(glycerol sebacate). J Biomed Mater Res A. 2003 Jul 1; 66(1):192-7.
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  273. Nashat AH, Langer R. Temporal characteristics of activation, deactivation, and restimulation of signal transduction following depolarization in the pheochromocytoma cell line PC12. Mol Cell Biol. 2003 Jul; 23(14):4788-95.
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  274. Kohane DS, Smith SE, Louis DN, Colombo G, Ghoroghchian P, Hunfeld NG, Berde CB, Langer R. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain. 2003 Jul; 104(1-2):415-21.
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  275. Baroli B, Shastri VP, Langer R. A method to protect sensitive molecules from a light-induced polymerizing environment. J Pharm Sci. 2003 Jun; 92(6):1186-95.
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  276. Radisic M, Euloth M, Yang L, Langer R, Freed LE, Vunjak-Novakovic G. High-density seeding of myocyte cells for cardiac tissue engineering. Biotechnol Bioeng. 2003 May 20; 82(4):403-14.
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  277. Akinc A, Lynn DM, Anderson DG, Langer R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. J Am Chem Soc. 2003 May 7; 125(18):5316-23.
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  278. Voskerician G, Shive MS, Shawgo RS, von Recum H, Anderson JM, Cima MJ, Langer R. Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials. 2003 May; 24(11):1959-67.
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  279. Lahann J, Balcells M, Lu H, Rodon T, Jensen KF, Langer R. Reactive polymer coatings: a first step toward surface engineering of microfluidic devices. Anal Chem. 2003 May 1; 75(9):2117-22.
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  280. LaVan DA, George PM, Langer R. Simple, three-dimensional microfabrication of electrodeposited structures. Angew Chem Int Ed Engl. 2003 Mar 17; 42(11):1262-5.
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  281. Yu B, Kim KH, So PT, Blankschtein D, Langer R. Visualization of oleic acid-induced transdermal diffusion pathways using two-photon fluorescence microscopy. J Invest Dermatol. 2003 Mar; 120(3):448-55.
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  282. Lee PJ, Langer R, Shastri VP. Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs. Pharm Res. 2003 Feb; 20(2):264-9.
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  283. Lahann J, Mitragotri S, Tran TN, Kaido H, Sundaram J, Choi IS, Hoffer S, Somorjai GA, Langer R. A reversibly switching surface. Science. 2003 Jan 17; 299(5605):371-4.
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  284. Potineni A, Lynn DM, Langer R, Amiji MM. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery. J Control Release. 2003 Jan 17; 86(2-3):223-34.
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  285. Sundaram M, Qi Y, Shriver Z, Liu D, Zhao G, Venkataraman G, Langer R, Sasisekharan R. Rational design of low-molecular weight heparins with improved in vivo activity. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):651-6.
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  286. Valente AX, Langer R, Stone HA, Edwards DA. Recent advances in the development of an inhaled insulin product. BioDrugs. 2003; 17(1):9-17.
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  287. Kohane DS, Holmes GL, Chau Y, Zurakowski D, Langer R, Cha BH. Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia. 2002 Dec; 43(12):1462-8.
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  288. Kumar N, Langer RS, Domb AJ. Polyanhydrides: an overview. Adv Drug Deliv Rev. 2002 Oct 16; 54(7):889-910.
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  289. Madry H, Padera R, Seidel J, Langer R, Freed LE, Trippel SB, Vunjak-Novakovic G. Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum Gene Ther. 2002 Sep 1; 13(13):1621-30.
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  290. Kohane DS, Plesnila N, Thomas SS, Le D, Langer R, Moskowitz MA. Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Brain Res. 2002 Aug 16; 946(2):206-13.
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  291. Tang H, Blankschtein D, Langer R. Effects of low-frequency ultrasound on the transdermal permeation of mannitol: comparative studies with in vivo and in vitro skin. J Pharm Sci. 2002 Aug; 91(8):1776-94.
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  292. Tang H, Wang CC, Blankschtein D, Langer R. An investigation of the role of cavitation in low-frequency ultrasound-mediated transdermal drug transport. Pharm Res. 2002 Aug; 19(8):1160-9.
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  293. Tang H, Blankschtein D, Langer R. Prediction of steady-state skin permeabilities of polar and nonpolar permeants across excised pig skin based on measurements of transient diffusion: characterization of hydration effects on the skin porous pathway. J Pharm Sci. 2002 Aug; 91(8):1891-907.
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  294. Carrier RL, Rupnick M, Langer R, Schoen FJ, Freed LE, Vunjak-Novakovic G. Effects of oxygen on engineered cardiac muscle. Biotechnol Bioeng. 2002 Jun 20; 78(6):617-25.
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  295. Akinc A, Langer R. Measuring the pH environment of DNA delivered using nonviral vectors: implications for lysosomal trafficking. Biotechnol Bioeng. 2002 Jun 5; 78(5):503-8.
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  296. Wang Y, Ameer GA, Sheppard BJ, Langer R. A tough biodegradable elastomer. Nat Biotechnol. 2002 Jun; 20(6):602-6.
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  297. Yu B, Hean Kim K, So PT, Blankschtein D, Langer R. Topographic heterogeneity in transdermal transport revealed by high-speed two-photon microscopy: determination of representative skin sample sizes. J Invest Dermatol. 2002 Jun; 118(6):1085-8.
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  298. Lee H, Cusick RA, Browne F, Ho Kim T, Ma PX, Utsunomiya H, Langer R, Vacanti JP. Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices. Transplantation. 2002 May 27; 73(10):1589-93.
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  299. Carrier RL, Rupnick M, Langer R, Schoen FJ, Freed LE, Vunjak-Novakovic G. Perfusion improves tissue architecture of engineered cardiac muscle. Tissue Eng. 2002 Apr; 8(2):175-88.
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  300. Levenberg S, Golub JS, Amit M, Itskovitz-Eldor J, Langer R. Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 2002 Apr 2; 99(7):4391-6.
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  301. Kohane DS, Lipp M, Kinney RC, Anthony DC, Louis DN, Lotan N, Langer R. Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res. 2002 Mar 5; 59(3):450-9.
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  302. Terahara T, Mitragotri S, Langer R. Porous resins as a cavitation enhancer for low-frequency sonophoresis. J Pharm Sci. 2002 Mar; 91(3):753-9.
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  303. Teng YD, Lavik EB, Qu X, Park KI, Ourednik J, Zurakowski D, Langer R, Snyder EY. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5):3024-9.
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  304. Blunk T, Sieminski AL, Gooch KJ, Courter DL, Hollander AP, Nahir AM, Langer R, Vunjak-Novakovic G, Freed LE. Differential effects of growth factors on tissue-engineered cartilage. Tissue Eng. 2002 Feb; 8(1):73-84.
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  305. Zelikin AN, Lynn DM, Farhadi J, Martin I, Shastri V, Langer R. Erodible conducting polymers for potential biomedical applications. Angew Chem Int Ed Engl. 2002 Jan 4; 41(1):141-4.
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  306. LaVan DA, Lynn DM, Langer R. Moving smaller in drug discovery and delivery. Nat Rev Drug Discov. 2002 Jan; 1(1):77-84.
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  307. Lavik E, Teng YD, Snyder E, Langer R. Seeding neural stem cells on scaffolds of PGA, PLA, and their copolymers. Methods Mol Biol. 2002; 198:89-97.
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  308. Santini JT, Richards AC, Scheidt RA, Cima MJ, Langer RS. Microchip technology in drug delivery. Ann Med. 2000 Sep; 32(6):377-9.
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  309. Langer RS, Vacanti JP. Tissue engineering: the challenges ahead. Sci Am. 1999 Apr; 280(4):86-9.
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  310. Langer RS. An interview with a distinguished pharmaceutical scientist: Robert S. Langer. Pharm Res. 1999 Apr; 16(4):475-7.
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  311. Ibim SM, Uhrich KE, Bronson R, El-Amin SF, Langer RS, Laurencin CT. Poly(anhydride-co-imides): in vivo biocompatibility in a rat model. Biomaterials. 1998 May; 19(10):941-51.
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  312. Niklason LE, Langer RS. Advances in tissue engineering of blood vessels and other tissues. Transpl Immunol. 1997 Dec; 5(4):303-6.
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  313. Johnson ME, Berk DA, Blankschtein D, Golan DE, Jain RK, Langer RS. Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems. Biophys J. 1996 Nov; 71(5):2656-68.
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  314. Yaszemski MJ, Payne RG, Hayes WC, Langer RS, Aufdemorte TB, Mikos AG. The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold. Tissue Eng. 1995; 1(1):41-52.
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  315. Langer RS, Peppas NA. Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials. 1981 Oct; 2(4):201-14.
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