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Bertha Kalifon Madras, Ph.D.

TitleProfessor of Psychobiology in the Department of Psychiatry
InstitutionHarvard Medical School
DepartmentPsychiatry
AddressN.E. Primate Research Ctr Harvard Medical School
Dep of Psychiatry
1 Pine Hill Dr
Southborough MA 01772
Phone508/624-8073
Fax508/624-8166

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Madras BK. History of the discovery of the antipsychotic dopamine d2 receptor: a basis for the dopamine hypothesis of schizophrenia. J Hist Neurosci. 2013 Jan; 22(1):62-78.
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  2. Spencer TJ, Madras BK, Fischman AJ, Krause J, La Fougère C. Striatal dopamine transporter binding in adults with ADHD. Am J Psychiatry. 2012 Jun; 169(6):665; author reply 666.
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  3. Torun L, Madras BK, Meltzer PC. Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters. Bioorg Med Chem. 2012 Apr 15; 20(8):2762-72.
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  4. Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T, Vallender EJ, Miller GM, Madras BK, Gonzalez RG. Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques. J Neurovirol. 2011 Oct; 17(5):455-68.
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  5. Madras BK. Candidate performance measures for screening for, assessing, and treating unhealthy substance use in hospitals. Ann Intern Med. 2011 Jan 4; 154(1):72-3; author reply 73-4.
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  6. Purushotham M, Sheri A, Pham-Huu DP, Madras BK, Janowsky A, Meltzer PC. The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes. Bioorg Med Chem Lett. 2011 Jan 1; 21(1):48-51.
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  7. Spencer TJ, Madras BK, Bonab AA, Dougherty DD, Clarke A, Mirto T, Martin J, Fischman AJ. A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride. Biol Psychiatry. 2010 Nov 15; 68(10):964-70.
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  8. Madras BK. Office of National Drug Control Policy: a scientist in drug policy in Washington, DC. Ann N Y Acad Sci. 2010 Feb; 1187:370-402.
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  9. Madras BK, Compton WM, Avula D, Stegbauer T, Stein JB, Clark HW. Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: comparison at intake and 6 months later. Drug Alcohol Depend. 2009 Jan 1; 99(1-3):280-95.
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  10. Verrico CD, Lynch L, Fahey MA, Fryer AK, Miller GM, Madras BK. MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. J Psychopharmacol. 2008 Mar; 22(2):187-202.
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  11. Spencer TJ, Biederman J, Madras BK, Dougherty DD, Bonab AA, Livni E, Meltzer PC, Martin J, Rauch S, Fischman AJ. Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane. Biol Psychiatry. 2007 Nov 1; 62(9):1059-61.
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  12. Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM. Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther. 2007 Apr; 321(1):116-27.
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  13. Pham-Huu DP, Deschamps JR, Liu S, Madras BK, Meltzer PC. Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem. 2007 Jan 15; 15(2):1067-82.
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  14. Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther. 2006 Nov; 319(2):561-9.
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  15. Madras BK, Fahey MA, Goulet M, Lin Z, Bendor J, Goodrich C, Meltzer PC, Elmaleh DR, Livni E, Bonab AA, Fischman AJ. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. J Pharmacol Exp Ther. 2006 Nov; 319(2):570-85.
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  16. Anderson CM, Maas LC, Frederick Bd, Bendor JT, Spencer TJ, Livni E, Lukas SE, Fischman AJ, Madras BK, Renshaw PF, Kaufman MJ. Cerebellar vermis involvement in cocaine-related behaviors. Neuropsychopharmacology. 2006 Jun; 31(6):1318-26.
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  17. Jassen AK, Yang H, Miller GM, Calder E, Madras BK. Receptor regulation of gene expression of axon guidance molecules: implications for adaptation. Mol Pharmacol. 2006 Jul; 70(1):71-7.
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  18. Spencer TJ, Biederman J, Ciccone PE, Madras BK, Dougherty DD, Bonab AA, Livni E, Parasrampuria DA, Fischman AJ. PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidate. Am J Psychiatry. 2006 Mar; 163(3):387-95.
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  19. Meltzer PC, Butler D, Deschamps JR, Madras BK. 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23; 49(4):1420-32.
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  20. Lin Z, Madras BK. Human genetics and pharmacology of neurotransmitter transporters. Handb Exp Pharmacol. 2006; (175):327-71.
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  21. Xiao D, Miller GM, Jassen A, Westmoreland SV, Pauley D, Madras BK. Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptation. Brain Res. 2006 Jan 5; 1067(1):67-77.
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  22. Verrico CD, Miller GM, Madras BK. MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl). 2007 Jan; 189(4):489-503.
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  23. Jassen AK, Brown JM, Panas HN, Miller GM, Xiao D, Madras BK. Variants of the primate vesicular monoamine transporter-2. Brain Res Mol Brain Res. 2005 Oct 3; 139(2):251-7.
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  24. Spencer TJ, Biederman J, Madras BK, Faraone SV, Dougherty DD, Bonab AA, Fischman AJ. In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter. Biol Psychiatry. 2005 Jun 1; 57(11):1293-300.
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  25. Fischman AJ, Madras BK. The neurobiology of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1; 57(11):1374-6.
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  26. Yatin SM, Miller GM, Madras BK. Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation. J Neurosci Methods. 2005 Apr 15; 143(1):69-78.
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  27. Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK. Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun; 313(3):983-94.
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  28. Madras BK, Miller GM, Fischman AJ. The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1; 57(11):1397-409.
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  29. Meltzer PC, Pham-Huu DP, Madras BK. Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem Lett. 2004 Dec 20; 14(24):6007-10.
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  30. Saka E, Goodrich C, Harlan P, Madras BK, Graybiel AM. Repetitive behaviors in monkeys are linked to specific striatal activation patterns. J Neurosci. 2004 Aug 25; 24(34):7557-65.
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  31. Madras BK and Meltzer, PC. . Serotonin transport inhibitors. 2004.
  32. Miller GM, Bendor J, Tiefenbacher S, Yang H, Novak MA, Madras BK. A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression. Mol Psychiatry. 2004 Jan; 9(1):99-108.
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  33. Meltzer, PC, Madras, BK, Blundell, P, Chen, Z. . Tropane analogs and methods for inhibition of monoamine transport. 2003.
  34. Meltzer PC, McPhee M, Madras BK. Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes. Bioorg Med Chem Lett. 2003 Nov 17; 13(22):4133-7.
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  35. Madras BK, Fahey MA, Miller GM, De La Garza R, Goulet M, Spealman RD, Meltzer PC, George SR, O'Dowd BF, Bonab AA, Livni E, Fischman AJ. Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. Eur J Pharmacol. 2003 Oct 31; 479(1-3):41-51.
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  36. Meltzer PC, Blundell P, Zona T, Yang L, Huang H, Bonab AA, Livni E, Fischman A, Madras BK. A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain. J Med Chem. 2003 Jul 31; 46(16):3483-96.
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  37. Meltzer; PC, Blundell; P, Madras; BK, Fischman; AJ, Jones; AG., Mahmood; A. . Dopamine transporter imaging agents. 2003.
  38. Meltzer PC, Wang P, Blundell P, Madras BK. Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. J Med Chem. 2003 Apr 10; 46(8):1538-45.
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  39. Meltzer; PC. Blundell; P, Wang; P; Madras; BK . Compounds with high monoamine transporter affinity. 2003.
  40. Meltzer PC, Liu S, Blanchette H, Blundell P, Madras BK. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorg Med Chem. 2002 Nov; 10(11):3583-91.
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  41. Meltzer; Peter C; Madras; BK.; Blundell; P Chen; Z. . Tropane analogs and methods for inhibition of monoamine transport. 2002.
  42. Yatin SM, Miller GM, Norton C, Madras BK. Dopamine transporter-dependent induction of C-Fos in HEK cells. Synapse. 2002 Jul; 45(1):52-65.
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  43. Zhdanova IV, Geiger DA, Schwagerl AL, Leclair OU, Killiany R, Taylor JA, Rosene DL, Moss MB, Madras BK. Melatonin promotes sleep in three species of diurnal nonhuman primates. Physiol Behav. 2002 Apr 1; 75(4):523-9.
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  44. Madras BK, Miller GM, Fischman AJ. The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD). Behav Brain Res. 2002 Mar 10; 130(1-2):57-63.
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  45. Seeman P, Madras B. Methylphenidate elevates resting dopamine which lowers the impulse-triggered release of dopamine: a hypothesis. Behav Brain Res. 2002 Mar 10; 130(1-2):79-83.
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  46. Meltzer; PC; Madras; BK.; Blundell; P; Chen; Z. . Tropane analogs and methods for inhibition of monoamine transport. 2002.
  47. Miller GM, Madras BK. Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Mol Psychiatry. 2002; 7(1):44-55.
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  48. Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK. Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse. 2001 Dec 1; 42(3):129-40.
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  49. Meltzer PC, Wang B, Chen Z, Blundell P, Jayaraman M, Gonzalez MD, George C, Madras BK. Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. J Med Chem. 2001 Aug 2; 44(16):2619-35.
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  50. Meschler JP, Howlett AC, Madras BK. Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates. Psychopharmacology (Berl). 2001 Jun; 156(1):79-85.
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  51. Fischman AJ, Bonab AA, Babich JW, Livni E, Alpert NM, Meltzer PC, Madras BK. [(11)C, (127)I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites. Synapse. 2001 Mar 15; 39(4):332-42.
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  52. Miller GM, Yatin SM, De La Garza R, Goulet M, Madras BK. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain Res Mol Brain Res. 2001 Feb 19; 87(1):124-43.
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  53. Dutta AK, Reith ME, Madras BK. Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse. 2001 Feb; 39(2):175-81.
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  54. Meltzer PC, Madras BK, Davison A, Blundell P, Mahmood A, Jones AG. . Dopamine transporter imaging agent. 2001.
  55. Miller GM, De La Garza R, Novak MA, Madras BK. Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders. Mol Psychiatry. 2001 Jan; 6(1):50-8.
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  56. De La Garza R, Madras BK. [(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain. Synapse. 2000 Sep 1; 37(3):232-44.
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  57. Meltzer PC, Blundell P, Yong YF, Chen Z, George C, Gonzalez MD, Madras BK. 2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. J Med Chem. 2000 Aug 10; 43(16):2982-91.
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  58. Madras BK, Miller GM, Meltzer PC, Brownell AL, Fischman AJ. Molecular and regional targets of cocaine in primate brain: liberation from prosaic views. Addict Biol. 2000 Jul 1; 5(3):351-9.
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  59. Meltzer PC, Blundell P, Huang H, Liu S, Yong YF, Madras BK. 3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter. Bioorg Med Chem. 2000 Mar; 8(3):581-90.
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  60. Meschler JP, Clarkson FA, Mathews PJ, Howlett AC, Madras BK. D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates. J Pharmacol Exp Ther. 2000 Mar; 292(3):952-9.
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  61. Goulet M, Madras BK. D(1) dopamine receptor agonists are more effective in alleviating advanced than mild parkinsonism in 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated monkeys. J Pharmacol Exp Ther. 2000 Feb; 292(2):714-24.
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  62. Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ. Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet. 1999 Dec 18-25; 354(9196):2132-3.
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  63. De La Garza R, Meltzer PC, Madras BK. Non-amine dopamine transporter probe [(3)H]tropoxene distributes to dopamine-rich regions of monkey brain. Synapse. 1999 Oct; 34(1):20-7.
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  64. Meltzer PC, Madras BK Blundell P Chen Z. . Tropane analogs and methods for inhibition of dopamine transport,. 1999.
  65. Morris ED, Bonab AA, Alpert NM, Fischman AJ, Madras BK, Christian BT. Concentration of dopamine transporters: to Bmax or not to Bmax? Synapse. 1999 May; 32(2):136-40.
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  66. Meltzer PC, Blundell P, Chen Z, Yong YF, Madras BK. Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters. Bioorg Med Chem Lett. 1999 Mar 22; 9(6):857-62.
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  67. Elmaleh DE, Madras BK, Meltzer PC, Hanson RN. . Substituted 2 carboxyalkyl 3(fluorophenyl) 8 (3 halopropen 2 yl) nortropanes and their use as imaging agents for neurodegenerative disorders. 1998.
  68. Seeman P, Madras BK. Anti-hyperactivity medication: methylphenidate and amphetamine. Mol Psychiatry. 1998 Sep; 3(5):386-96.
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  69. Madras BK and Meltzer PC. . Bridge-substituted tropanes for methods of imaging and therapy. 1998.
  70. Fischman AJ, Bonab AA, Babich JW, Palmer EP, Alpert NM, Elmaleh DR, Callahan RJ, Barrow SA, Graham W, Meltzer PC, Hanson RN, Madras BK. Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun; 29(2):128-41.
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  71. Madras BK, Meltzer PC, Liang AY, Elmaleh DR, Babich J, Fischman AJ. Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain. Synapse. 1998 Jun; 29(2):93-104.
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  72. Madras BK, Gracz LM, Fahey MA, Elmaleh D, Meltzer PC, Liang AY, Stopa EG, Babich J, Fischman AJ. Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain. Synapse. 1998 Jun; 29(2):116-27.
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  73. Madras BK, Gracz LM, Meltzer PC, Liang AY, Elmaleh DR, Kaufman MJ, Fischman AJ. Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brain. Synapse. 1998 Jun; 29(2):105-15.
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  74. Meltzer PC, Liang AY, Blundell P, Gonzalez MD, Chen Z, George C, Madras BK. 2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. J Med Chem. 1997 Aug 15; 40(17):2661-73.
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  75. Meltzer PC, Blundell P, Jones AG, Mahmood A, Garada B, Zimmerman RE, Davison A, Holman BL, Madras BK. A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain. J Med Chem. 1997 Jun 6; 40(12):1835-44.
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  76. Meltzer PC, Madras BK. Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur J Nucl Med. 1997 Apr; 24(4):462-3.
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  77. Fischman AJ, Babich JW, Elmaleh DR, Barrow SA, Meltzer P, Hanson RN, Madras BK. SPECT imaging of dopamine transporter sites in normal and MPTP-Treated rhesus monkeys. J Nucl Med. 1997 Jan; 38(1):144-50.
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  78. Madras BK, Pristupa ZB, Niznik HB, Liang AY, Blundell P, Gonzalez MD, Meltzer PC. Nitrogen-based drugs are not essential for blockade of monoamine transporters. Synapse. 1996 Dec; 24(4):340-8.
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  79. Morris ED, Babich JW, Alpert NM, Bonab AA, Livni E, Weise S, Hsu H, Christian BT, Madras BK, Fischman AJ. Quantification of dopamine transporter density in monkeys by dynamic PET imaging of multiple injections of 11C-CFT. Synapse. 1996 Nov; 24(3):262-72.
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  80. Brownell AL, Elmaleh DR, Meltzer PC, Shoup TM, Brownell GL, Fischman AJ, Madras BK. Cocaine congeners as PET imaging probes for dopamine terminals. J Nucl Med. 1996 Jul; 37(7):1186-92.
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  81. Elmaleh DR, Fischman AJ, Shoup TM, Byon C, Hanson RN, Liang AY, Meltzer PC, Madras BK. Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites. J Nucl Med. 1996 Jul; 37(7):1197-202.
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  82. Madras BK and Meltzer PC. . Cocaine analogues and their use as cocaine drug therapies and therapeutic and imaging agents for neurodegenerative disorders. 1996.
  83. Madras BK, Jones AG, Mahmood A, Zimmerman RE, Garada B, Holman BL, Davison A, Blundell P, Meltzer PC. Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging. Synapse. 1996 Mar; 22(3):239-46.
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  84. Bergman J, Spealman RD, Madras BK, Rosenzweig-Lipson S. Agonist efficacy and the behavioral effects of dopamine D1 receptor ligands: drug interaction studies in squirrel monkeys. J Pharmacol Exp Ther. 1996 Mar; 276(3):942-50.
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  85. Elmaleh DE, Madras BK, Hanson R, Meltzer PC . Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl)nortropanes and their use as imaging agents for neurodegenerative disorders. 1996.
  86. Meltzer PC, Liang AY, Madras BK. 2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series. J Med Chem. 1996 Jan 19; 39(2):371-9.
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  87. Gracz LM, Madras BK. [3H]WIN 35,428 ([3H]CFT) binds to multiple charge-states of the solubilized dopamine transporter in primate striatum. J Pharmacol Exp Ther. 1995 Jun; 273(3):1224-34.
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  88. Madras BK, Kaufman MJ. Cocaine accumulates in dopamine-rich regions of primate brain after i.v. administration: comparison with mazindol distribution. Synapse. 1994 Nov; 18(3):261-75.
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  89. Meltzer PC, Liang AY, Madras BK. The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites. J Med Chem. 1994 Jun 24; 37(13):2001-10.
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  90. Madras BK, Reith ME, Meltzer PC, Dutta AK. O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen. Eur J Pharmacol. 1994 Apr 15; 267(2):167-73.
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  91. Madras BK. 11C-WIN 35,428 for detecting dopamine depletion in mild Parkinson's disease. Ann Neurol. 1994 Mar; 35(3):376-7.
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  92. Brownell AL, Hantraye P, Wullner U, Hamberg L, Shoup T, Elmaleh DR, Frim DM, Madras BK, Brownell GL, Rosen BR, et al. PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates. Exp Neurol. 1994 Jan; 125(1):41-51.
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  93. Madras BK, Elmaleh DR, Meltzer PC, Liang AY, Brownell GL, Brownell AL. Positron emission tomography of cocaine binding sites on the dopamine transporter. NIDA Res Monogr. 1994; 138:57-69.
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  94. Kaufman MJ, Madras BK. [3H]CFT ([3H]WIN 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey. Brain Res. 1993 May 21; 611(2):322-5.
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  95. Meltzer PC, Liang AY, Brownell AL, Elmaleh DR, Madras BK. Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging. J Med Chem. 1993 Apr 2; 36(7):855-62.
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  96. Kaufman MJ, Madras BK. Distribution of cocaine recognition sites in monkey brain: II. Ex vivo autoradiography with [3H]CFT and [125I]RTI-55. Synapse. 1992 Oct; 12(2):99-111.
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  97. Neumeyer JL, Baindur N, Bakthavachalam V, Yuan J, Madras BK, Kula NS, Campbell A, Baldessarini RJ. Alan Horn Memorial Lecture. Selective probes for characterization of dopamine D1 and D2 receptors. Neurochem Int. 1992 Mar; 20 Suppl:63S-68S.
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  98. Hantraye P, Brownell AL, Elmaleh D, Spealman RD, Wüllner U, Brownell GL, Madras BK, Isacson O. Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism. Neuroreport. 1992 Mar; 3(3):265-8.
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  99. Spealman RD, Bergman J, Madras BK, Kamien JB, Melia KF. Role of D1 and D2 dopamine receptors in the behavioral effects of cocaine. Neurochem Int. 1992 Mar; 20 Suppl:147S-152S.
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  100. Rosenzweig-Lipson S, Bergman J, Spealman RD, Madras BK. Stereoselective behavioral effects of Lu 19-005 in monkeys: relation to binding at cocaine recognition sites. Psychopharmacology (Berl). 1992; 107(2-3):186-94.
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  101. Schumacher JM, Hantraye P, Brownell AL, Riche D, Madras BK, Davenport PD, Maziere M, Elmaleh DR, Brownell GL, Isacson O. A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures. Cell Transplant. 1992; 1(4):313-22.
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  102. Bakthavachalam V, Baindur N, Madras BK, Neumeyer JL. Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands. J Med Chem. 1991 Nov; 34(11):3235-41.
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  103. Kaufman MJ, Spealman RD, Madras BK. Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT. Synapse. 1991 Nov; 9(3):177-87.
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  104. Spealman RD, Bergman J, Madras BK, Melia KF. Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes. J Pharmacol Exp Ther. 1991 Sep; 258(3):945-53.
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  105. Kaufman MJ, Madras BK. Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum. Synapse. 1991 Sep; 9(1):43-9.
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  106. Bergman J, Madras BK, Spealman RD. Behavioral effects of D1 and D2 dopamine receptor antagonists in squirrel monkeys. J Pharmacol Exp Ther. 1991 Sep; 258(3):910-7.
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  107. Spealman RD, Bergman J, Madras BK. Self-administration of the high-affinity cocaine analog 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane. Pharmacol Biochem Behav. 1991 Aug; 39(4):1011-3.
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  108. Milius RA, Saha JK, Madras BK, Neumeyer JL. Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor. J Med Chem. 1991 May; 34(5):1728-31.
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  109. Madras BK, Canfield DR, Pfaelzer C, Vittimberga FJ, Difiglia M, Aronin N, Bakthavachalam V, Baindur N, Neumeyer JL. Fluorescent and biotin probes for dopamine receptors: D1 and D2 receptor affinity and selectivity. Mol Pharmacol. 1990 Jun; 37(6):833-9.
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  110. Madras BK, Kamien JB, Fahey MA, Canfield DR, Milius RA, Saha JK, Neumeyer JL, Spealman RD. N-modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors. Pharmacol Biochem Behav. 1990 Apr; 35(4):949-53.
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  111. Canfield DR, Spealman RD, Kaufman MJ, Madras BK. Autoradiographic localization of cocaine binding sites by [3H]CFT ([3H]WIN 35,428) in the monkey brain. Synapse. 1990; 6(2):189-95.
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  112. Spealman RD, Madras BK, Bergman J. Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule-controlled behavior. J Pharmacol Exp Ther. 1989 Oct; 251(1):142-9.
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  113. Bergman J, Madras BK, Johnson SE, Spealman RD. Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys. J Pharmacol Exp Ther. 1989 Oct; 251(1):150-5.
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  114. Madras BK, Fahey MA, Bergman J, Canfield DR, Spealman RD. Effects of cocaine and related drugs in nonhuman primates. I. [3H]cocaine binding sites in caudate-putamen. J Pharmacol Exp Ther. 1989 Oct; 251(1):131-41.
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  115. Madras BK, Spealman RD, Fahey MA, Neumeyer JL, Saha JK, Milius RA. Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane. Mol Pharmacol. 1989 Oct; 36(4):518-24.
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  116. Madras BK, Fahey MA, Canfield DR, Spealman RD. D1 and D2 dopamine receptors in caudate-putamen of nonhuman primates (Macaca fascicularis). J Neurochem. 1988 Sep; 51(3):934-43.
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  117. Madras BK, Seeman P. Drug potencies on partially purified brain D2 dopamine receptors. J Neurochem. 1985 Mar; 44(3):856-61.
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  118. Okazaki MM, Madras BK, Livingston KE, Spero L, Burnham WM. Enhancement of 3H-phenytoin binding by diazepam and (+)bicuculline. Life Sci. 1983 Aug 1; 33(5):409-14.
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  119. Whitaker PM, Kish SJ, Madras BK. Direct binding assays in determining psychotropic drug mechanism of action. Rev Pure Appl Pharmacol Sci. 1983 Jul-Sep; 4(3):271-338.
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  120. Chan B, Madras BK. Partial purification of [3H]mianserin binding sites. Eur J Pharmacol. 1983 Mar 4; 87(4):357-65.
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  121. Madras BK, Chan B. Modulation of dopamine receptor binding by ascorbic acid. Adv Biochem Psychopharmacol. 1983; 37:275-87.
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  122. Chan B, Madras BK. [3H]Mianserin binding to solubilized membranes of frontal cortex. Eur J Pharmacol. 1982 Sep 10; 83(1-2):1-10.
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  123. Chan B, Seeman P, Davis A, Madras BK. Ascorbate injury and EDTA (or manganese) protection of D2-dopamine receptors. Eur J Pharmacol. 1982 Jun 16; 81(1):111-6.
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  124. Davis A, Madras BK, Seeman P. Solubilized receptors for [3H]dopamine (D3 binding sites) from canine brain. Biochem Pharmacol. 1982 Apr 1; 31(7):1183-7.
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  125. Madras BK, Davis A, Seeman P. Comparison of soluble dopamine D2-receptors from three species. Eur J Pharmacol. 1982 Mar 26; 78(4):431-8.
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  126. Chan B, Madras BK, Davis A, Seeman P. Assay for soluble dopamine receptors by the precipitation method. Eur J Pharmacol. 1981 Aug 27; 74(1):53-9.
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  127. Burnham WM, Spero L, Okazaki MM, Madras BK. Saturable binding of [3H]phenytoin to rat brain membrane fraction. Can J Physiol Pharmacol. 1981 Apr; 59(4):402-7.
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  128. Davis A, Madras B, Seeman P. Solubilization of neuroleptic/dopamine receptors of human brain striatum. Eur J Pharmacol. 1981 Mar 26; 70(3):321-9.
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  129. Madras BK, Davis A, Chan B, Seeman P. Solubilized dopamine/neuroleptic receptors (D2-type). Prog Neuropsychopharmacol. 1981; 5(5-6):543-8.
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  130. Fernstrom JD, Hirsch MJ, Madras BK, Sudarsky L. Effects of skim milk, whole milk and light cream on serum tryptophan binding and brain tryptophan concentrations in rats. J Nutr. 1975 Oct; 105(10):1359-62.
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  131. Madras BK, Cohen EL, Messing R, Munro HN, Wurtman RJ. Relevance of free tryptophan in serum to tissue tryptophan concentrations. Metabolism. 1974 Dec; 23(12):1107-16.
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  132. Madras BK, Cohen EL, Munro HN, Wurtman RJ. Elevation of serum free tryptophan, but not brain tryptophan, by serum nonesterified fatty acids. Adv Biochem Psychopharmacol. 1974; 11(0):143-51.
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  133. Madras BK, Cohen EL, Fernstrom JD, Larin F, Munro HN, Wurtman RJ. Letter: Dietary carbohydrate increases brain tryptophan and decreases free plasma tryptophan. Nature. 1973 Jul 6; 244(5410):34-5.
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  134. Lipsett D, Madras BK, Wurtman RJ, Munro HN. Serum tryptophan level after carbohydrate ingestion: selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids. Life Sci II. 1973 Jan 22; 12(2):57-64.
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  135. Sourkes TL, Missala K, Madras BK. Effect of yohimbine on tryptophan metabolism. J Pharmacol Exp Ther. 1969 Feb; 165(2):289-93.
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  136. Madras BK, Sourkes TL. Formation of respiratory 14CO2 from variously labeled forms of tryptophan-14C in intact and adrenalectomized rats. Arch Biochem Biophys. 1968 Jun; 125(3):829-36.
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  137. Madras BK, Sourkes TL. Effects of drugs on the metabolism of tryptophan. Alpha-hydrazinotryptophan and other amino acid analogs. Biochem Pharmacol. 1968 Jun; 17(6):1037-47.
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  138. Horowitz B, Madras BK, Meister A, Old LJ, Boyes EA, Stockert E. Asparagine synthetase activity of mouse leukemias. Science. 1968 May 3; 160(3827):533-5.
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  139. Madras BK, Sourkes TL. Metabolism of alpha-methyltryptophan. Biochem Pharmacol. 1965 Nov; 14(11):1499-506.
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