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Last Name
Institution

Gabriel Corfas, PH.D.

TitleProfessor of Neurology
InstitutionChildren's Hospital Boston
DepartmentNeurology
AddressChildrens Hospital
Neurobiology Program, CLS 12
300 Longwood Ave
Boston MA 02115
Phone617/919-2200
Fax617/919-2772
Other Positions
TitleProfessor of Otology and Laryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtology and Laryngology


 Research 
 research resources
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Cellular Neuroscience Core Laboratory (CHB) - Core services (13) and Instruments (17)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Song S, Rosen KM, Corfas G. Biological function of nuclear receptor tyrosine kinase action. Cold Spring Harb Perspect Biol. 2013; 5(7).
    View in: PubMed
  2. Xu P, Rosen KM, Hedstrom K, Rey O, Guha S, Hart C, Corfas G. Nerve injury induces glial cell line-derived neurotrophic factor (gdnf) expression in schwann cells through purinergic signaling and the pkc-pkd pathway. Glia. 2013 Jul; 61(7):1029-40.
    View in: PubMed
  3. Wan G, Corfas G, Stone JS. Inner ear supporting cells: Rethinking the silent majority. Semin Cell Dev Biol. 2013 May; 24(5):448-59.
    View in: PubMed
  4. Makinodan M, Rosen KM, Ito S, Corfas G. A critical period for social experience-dependent oligodendrocyte maturation and myelination. Science. 2012 Sep 14; 337(6100):1357-60.
    View in: PubMed
  5. Sandau US, Alderman Z, Corfas G, Ojeda SR, Raber J. Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations. PLoS One. 2012; 7(4):e36424.
    View in: PubMed
  6. Zilberstein Y, Liberman MC, Corfas G. Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. J Neurosci. 2012 Jan 11; 32(2):405-10.
    View in: PubMed
  7. Berde CB, Athiraman U, Yahalom B, Zurakowski D, Corfas G, Bognet C. Tetrodotoxin-bupivacaine-epinephrine combinations for prolonged local anesthesia. Mar Drugs. 2011 Dec; 9(12):2717-28.
    View in: PubMed
  8. Puram SV, Riccio A, Koirala S, Ikeuchi Y, Kim AH, Corfas G, Bonni A. A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain. Genes Dev. 2011 Dec 15; 25(24):2659-73.
    View in: PubMed
  9. Clasadonte J, Poulain P, Hanchate NK, Corfas G, Ojeda SR, Prevot V. Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):16104-9.
    View in: PubMed
  10. Yahalom B, Athiraman U, Soriano SG, Zurakowski D, Carpino EA, Corfas G, Berde CB. Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. Anesthesiology. 2011 Jun; 114(6):1325-35.
    View in: PubMed
  11. Sandau US, Mungenast AE, Alderman Z, Sardi SP, Fogel AI, Taylor B, Parent AS, Biederer T, Corfas G, Ojeda SR. SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual development. Endocrinology. 2011 Jun; 152(6):2364-76.
    View in: PubMed
  12. Sandau US, Mungenast AE, McCarthy J, Biederer T, Corfas G, Ojeda SR. The synaptic cell adhesion molecule, SynCAM1, mediates astrocyte-to-astrocyte and astrocyte-to-GnRH neuron adhesiveness in the mouse hypothalamus. Endocrinology. 2011 Jun; 152(6):2353-63.
    View in: PubMed
  13. Gómez-Casati ME, Murtie JC, Rio C, Stankovic K, Liberman MC, Corfas G. Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):17005-10.
    View in: PubMed
  14. Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25; 65(6):886-98.
    View in: PubMed
  15. Koirala S, Corfas G. Identification of novel glial genes by single-cell transcriptional profiling of Bergmann glial cells from mouse cerebellum. PLoS One. 2010; 5(2):e9198.
    View in: PubMed
  16. Gómez-Casati ME, Murtie J, Taylor B, Corfas G. Cell-specific inducible gene recombination in postnatal inner ear supporting cells and glia. J Assoc Res Otolaryngol. 2010 Mar; 11(1):19-26.
    View in: PubMed
  17. Koirala S, Jin Z, Piao X, Corfas G. GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. J Neurosci. 2009 Jun 10; 29(23):7439-49.
    View in: PubMed
  18. Lok J, Sardi SP, Guo S, Besancon E, Ha DM, Rosell A, Kim WJ, Corfas G, Lo EH. Neuregulin-1 signaling in brain endothelial cells. J Cereb Blood Flow Metab. 2009 Jan; 29(1):39-43.
    View in: PubMed
  19. Benny O, Fainaru O, Adini A, Cassiola F, Bazinet L, Adini I, Pravda E, Nahmias Y, Koirala S, Corfas G, D'Amato RJ, Folkman J. An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nat Biotechnol. 2008 Jul; 26(7):799-807.
    View in: PubMed
  20. Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci. 2008 May 28; 28(22):5817-26.
    View in: PubMed
  21. Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, Tan PH, Gao YJ, Roy K, Corfas G, Lo EH, Ji RR. Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med. 2008 Mar; 14(3):331-6.
    View in: PubMed
  22. Murtie JC, Macklin WB, Corfas G. Morphometric analysis of oligodendrocytes in the adult mouse frontal cortex. J Neurosci Res. 2007 Aug 1; 85(10):2080-6.
    View in: PubMed
  23. Roy K, Murtie JC, El-Khodor BF, Edgar N, Sardi SP, Hooks BM, Benoit-Marand M, Chen C, Moore H, O'Donnell P, Brunner D, Corfas G. Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):8131-6.
    View in: PubMed
  24. Buxbaum JD, Georgieva L, Young JJ, Plescia C, Kajiwara Y, Jiang Y, Moskvina V, Norton N, Peirce T, Williams H, Craddock NJ, Carroll L, Corfas G, Davis KL, Owen MJ, Harroch S, Sakurai T, O'Donovan MC. Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Mol Psychiatry. 2008 Feb; 13(2):162-72.
    View in: PubMed
  25. Sugawara M, Murtie JC, Stankovic KM, Liberman MC, Corfas G. Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear. J Comp Neurol. 2007 Mar 1; 501(1):30-7.
    View in: PubMed
  26. Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell. 2006 Oct 6; 127(1):185-97.
    View in: PubMed
  27. Rieff HI, Corfas G. ErbB receptor signalling regulates dendrite formation in mouse cerebellar granule cells in vivo. Eur J Neurosci. 2006 Apr; 23(8):2225-9.
    View in: PubMed
  28. Chen S, Velardez MO, Warot X, Yu ZX, Miller SJ, Cros D, Corfas G. Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function. J Neurosci. 2006 Mar 22; 26(12):3079-86.
    View in: PubMed
  29. Patten BA, Sardi SP, Koirala S, Nakafuku M, Corfas G. Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms. J Neurosci. 2006 Mar 22; 26(12):3102-8.
    View in: PubMed
  30. Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE. Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1319-24.
    View in: PubMed
  31. Gierdalski M, Sardi SP, Corfas G, Juliano SL. Endogenous neuregulin restores radial glia in a (ferret) model of cortical dysplasia. J Neurosci. 2005 Sep 14; 25(37):8498-504.
    View in: PubMed
  32. Sugawara M, Corfas G, Liberman MC. Influence of supporting cells on neuronal degeneration after hair cell loss. J Assoc Res Otolaryngol. 2005 Jun; 6(2):136-47.
    View in: PubMed
  33. Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 2005 Apr 21; 46(2):191-204.
    View in: PubMed
  34. Prevot V, Lomniczi A, Corfas G, Ojeda SR. erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function. Endocrinology. 2005 Mar; 146(3):1465-72.
    View in: PubMed
  35. Corfas G, Velardez MO, Ko CP, Ratner N, Peles E. Mechanisms and roles of axon-Schwann cell interactions. J Neurosci. 2004 Oct 20; 24(42):9250-60.
    View in: PubMed
  36. Stankovic K, Rio C, Xia A, Sugawara M, Adams JC, Liberman MC, Corfas G. Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear. J Neurosci. 2004 Oct 6; 24(40):8651-61.
    View in: PubMed
  37. Corfas G, Roy K, Buxbaum JD. Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nat Neurosci. 2004 Jun; 7(6):575-80.
    View in: PubMed
  38. Satchi-Fainaro R, Puder M, Davies JW, Tran HT, Sampson DA, Greene AK, Corfas G, Folkman J. Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nat Med. 2004 Mar; 10(3):255-61.
    View in: PubMed
  39. Okada M, Corfas G. Neuregulin1 downregulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse. Hippocampus. 2004; 14(3):337-44.
    View in: PubMed
  40. Stankovic KM, Corfas G. Real-time quantitative RT-PCR for low-abundance transcripts in the inner ear: analysis of neurotrophic factor expression. Hear Res. 2003 Nov; 185(1-2):97-108.
    View in: PubMed
  41. Chen S, Rio C, Ji RR, Dikkes P, Coggeshall RE, Woolf CJ, Corfas G. Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Nat Neurosci. 2003 Nov; 6(11):1186-93.
    View in: PubMed
  42. Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci. 2003 Aug 6; 23(18):7084-92.
    View in: PubMed
  43. Patten BA, Peyrin JM, Weinmaster G, Corfas G. Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. J Neurosci. 2003 Jul 9; 23(14):6132-40.
    View in: PubMed
  44. Chen WG, West AE, Tao X, Corfas G, Szentirmay MN, Sawadogo M, Vinson C, Greenberg ME. Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. J Neurosci. 2003 Apr 1; 23(7):2572-81.
    View in: PubMed
  45. Prevot V, Rio C, Cho GJ, Lomniczi A, Heger S, Neville CM, Rosenthal NA, Ojeda SR, Corfas G. Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes. J Neurosci. 2003 Jan 1; 23(1):230-9.
    View in: PubMed
  46. Sobeih MM, Corfas G. Extracellular factors that regulate neuronal migration in the central nervous system. Int J Dev Neurosci. 2002 Jun-Aug; 20(3-5):349-57.
    View in: PubMed
  47. Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA. BDNF stimulates migration of cerebellar granule cells. Development. 2002 Mar; 129(6):1435-42.
    View in: PubMed
  48. Tao X, West AE, Chen WG, Corfas G, Greenberg ME. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31; 33(3):383-95.
    View in: PubMed
  49. Rio C, Dikkes P, Liberman MC, Corfas G. Glial fibrillary acidic protein expression and promoter activity in the inner ear of developing and adult mice. J Comp Neurol. 2002 Jan 7; 442(2):156-62.
    View in: PubMed
  50. Sanchez RM, Koh S, Rio C, Wang C, Lamperti ED, Sharma D, Corfas G, Jensen FE. Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures. J Neurosci. 2001 Oct 15; 21(20):8154-63.
    View in: PubMed
  51. Mason HA, Ito S, Corfas G. Extracellular signals that regulate the tangential migration of olfactory bulb neuronal precursors: inducers, inhibitors, and repellents. J Neurosci. 2001 Oct 1; 21(19):7654-63.
    View in: PubMed
  52. Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell. 2001 Apr 20; 105(2):233-44.
    View in: PubMed
  53. Rio C, Buxbaum JD, Peschon JJ, Corfas G. Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4. J Biol Chem. 2000 Apr 7; 275(14):10379-87.
    View in: PubMed
  54. Montgomery JM, Corfas G, Mills RG. Intracellular signaling molecules involved in an inhibitory factor-induced decrease in fetal-type AChR expression. J Neurobiol. 2000 Feb 5; 42(2):190-201.
    View in: PubMed
  55. Rieff HI, Raetzman LT, Sapp DW, Yeh HH, Siegel RE, Corfas G. Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells. J Neurosci. 1999 Dec 15; 19(24):10757-66.
    View in: PubMed
  56. Tevosian SG, Deconinck AE, Cantor AB, Rieff HI, Fujiwara Y, Corfas G, Orkin SH. FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 2; 96(3):950-5.
    View in: PubMed
  57. Elenius K, Corfas G, Paul S, Choi CJ, Rio C, Plowman GD, Klagsbrun M. A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem. 1997 Oct 17; 272(42):26761-8.
    View in: PubMed
  58. Rio C, Rieff HI, Qi P, Khurana TS, Corfas G. Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron. 1997 Jul; 19(1):39-50.
    View in: PubMed
  59. Goodearl AD, Yee AG, Sandrock AW, Corfas G, Fischbach GD. ARIA is concentrated in the synaptic basal lamina of the developing chick neuromuscular junction. J Cell Biol. 1995 Sep; 130(6):1423-34.
    View in: PubMed
  60. Corfas G, Rosen KM, Aratake H, Krauss R, Fischbach GD. Differential expression of ARIA isoforms in the rat brain. Neuron. 1995 Jan; 14(1):103-15.
    View in: PubMed
  61. Vartanian T, Corfas G, Li Y, Fischbach GD, Stefansson K. A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24):11626-30.
    View in: PubMed
  62. Fischbach GD, Aratake H, Corfas G, Falls DL, Goodearl A, Rosen KM. Trophic interactions at developing synapses. Prog Clin Biol Res. 1994; 390:173-90.
    View in: PubMed
  63. Corfas G, Fischbach GD. The number of Na+ channels in cultured chick muscle is increased by ARIA, an acetylcholine receptor-inducing activity. J Neurosci. 1993 May; 13(5):2118-25.
    View in: PubMed
  64. Falls DL, Rosen KM, Corfas G, Lane WS, Fischbach GD. ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell. 1993 Mar 12; 72(5):801-15.
    View in: PubMed
  65. Corfas G, Falls DL, Fischbach GD. ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1624-8.
    View in: PubMed
  66. Corfas G, Dudai Y. Morphology of a sensory neuron in Drosophila is abnormal in memory mutants and changes during aging. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7252-6.
    View in: PubMed
  67. Corfas G, Dudai Y. Pharmacological evidence for the involvement of the cAMP cascade in sensory fatigue in Drosophila. J Comp Physiol A. 1990 Aug; 167(3):437-40.
    View in: PubMed
  68. Corfas G, Dudai Y. Adaptation and fatigue of a mechanosensory neuron in wild-type Drosophila and in memory mutants. J Neurosci. 1990 Feb; 10(2):491-9.
    View in: PubMed
  69. Falls DL, Harris DA, Johnson FA, Morgan MM, Corfas G, Fischbach GD. Mr 42,000 ARIA: a protein that may regulate the accumulation of acetylcholine receptors at developing chick neuromuscular junctions. Cold Spring Harb Symp Quant Biol. 1990; 55:397-406.
    View in: PubMed
  70. Corfas G, Dudai Y. Habituation and dishabituation of a cleaning reflex in normal and mutant Drosophila. J Neurosci. 1989 Jan; 9(1):56-62.
    View in: PubMed
  71. Dudai Y, Corfas G, Hazvi S. What is the possible contribution of Ca2+-stimulated adenylate cyclase to acquisition, consolidation and retention of an associative olfactory memory in Drosophila. J Comp Physiol A. 1988 Jan; 162(1):101-9.
    View in: PubMed
  72. Dudai Y, Buxbaum J, Corfas G, Orgad S, Segal D, Sher B, Uzzan A, Zvi S. Defective cAMP metabolism and defective memory in Drosophila. Acta Biochim Biophys Hung. 1986; 21(3):177-92.
    View in: PubMed
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