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Joshua Peter Klein, M.D., Ph.D.

TitleAssistant Professor of Neurology
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressBrigham and Womens Hospital
Department of Neurology, Room AB-124
75 Francis St
Boston MA 02115
Phone617/525-7623
Fax617/732-6083

 Biography 
 awards and honors
2005 - International Student Delegate, Academy of Achievement
2009 - Dr. Edison H. and Sallie Y. Miyawaki Neuroanatomy Teaching Award, Harvard Medical School
2012 - Teacher of the Year, Brigham and Women's Hospital & Massachusetts General Hospital Neurology
2012 - Diplomate in Neuroimaging, United Council of Neurologic Subspecialties
2013 - Vice Chair, Neurohospitalist Section, American Academy of Neurology
2013 - Chair, Membership Committee, American Society of Neuroimaging
2013 - Associate Editor, Journal of Neuroimaging

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bega D, Wang N, Klein JP. Reversible palinacousis from intracranial metastases. The Neurohospitalist (in press). 2013.
  2. Bove RM, Klein JP. Neuroradiology in women of childbearing age. Continuum (in press). 2013.
  3. Dietrich J, Klein JP. Imaging of cancer therapy induced central nervous system toxicity. Neurologic Clinics (in press). 2013.
  4. Edlow BL, Haynes RL, Takahashi E, Klein JP, Cummings P, Benner T, Greer DM, Greenberg SM, Wu O, Kinney HC, Folkerth RD. Disconnection of the Ascending Arousal System in Traumatic Coma. J Neuropathol Exp Neurol. 2013 May 7.
    View in: PubMed
  5. Lyons JL, Neagu MR, Norton IH, Klein JP. Diffusion tensor imaging in brainstem tuberculoma. Journal of Clinical Neuroscience (in press). 2013.
  6. Awosika OO, Lyons JL, Ciarlini P, Phillips RE, Alfson ED, Johnson EL, Koo S, Marty F, Drew C, Zaki S, Folkerth RD, Klein JP. Fatal adenovirus encephalomyeloradiculitis in an umbilical cord stem cell transplant recipient. Neurology. 2013 Apr 17.
    View in: PubMed
  7. Vodopivec I, Klein JP, Prasad S. Bilateral cervical internal carotid artery dissections in Eagle syndrome. Neurol Clin Pract. 2013; 3:173-4.
  8. Wahlster S, Berkowitz AL, Zepeda R, Sagar VI, Lyons JL, Klein JP, Mejia N. Neurology and global health: Initiatives led by residents and staff from the Partners Neurology Program. Proceedings of the Annual Meeting of the American Academy of Neurology, San Diego, CA. 2013.
  9. Espinosa PS, Falcone N, Fee D, Swartz K, Del Pozo PE, Ryan S, Laccheo I, Berkowitz AL, Torres A, Bayas A, Paciorkowski A, Cash SS, Dvorquez D, Ortiz-Prado E, Salazar-Uribe JC, Klein JP, Lyons JL, Wahlster S, Cambi F, Vazquez B, Baumann R, Dworetzky BA. Decreasing the epilepsy treatment gap in the developing world: the epilepsy medical mission to the Amazon rain forest in Tena, Ecuador Report 2009-2012. Proceedings of the Annual Meeting of the American Academy of Neurology, San Diego, CA. 2013.
  10. Klein JP, Stankiewicz JM. Student self assessment in a neurology clerkship. Proceedings of the Annual Meeting of the American Academy of Neurology, San Diego, CA. 2013.
  11. Berkowitz AL, Jha RM, Klein JP, Amato AA. Clinical Reasoning: An 85-year-old man with paresthesias and an unsteady gait. Neurology. 2013 Mar 19; 80(12):e120-6.
    View in: PubMed
  12. Ravi A, Rao VR, Klein JP. Dystextia: acute stroke in the modern age. JAMA Neurol. 2013 Mar 1; 70(3):404-5.
    View in: PubMed
  13. Klein JP. On the Role of Screening for Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease. AJNR Am J Neuroradiol. 2013 Feb 22.
    View in: PubMed
  14. Jha RM, Klein JP. Clinical anatomy and imaging of the cranial nerves and skull base. Semin Neurol. 2012 Sep; 32(4):332-46.
    View in: PubMed
  15. Velez-Ruiz NJ, Klein JP. Neuroimaging in the evaluation of epilepsy. Semin Neurol. 2012 Sep; 32(4):361-73.
    View in: PubMed
  16. Klein JP. Diagnostic neuroimaging. Semin Neurol. 2012 Sep; 32(4):271-2.
    View in: PubMed
  17. Jha RM, Berkowitz AL, Klein JP. Evolution of hypoxic-ischemic injury. The Neurohospitalist. 2012; 3(1):46.
  18. Mallery RM, Klein JP, Pless ML. Isolated sixth nerve palsy from hemorrhage of a pontine cavernous malformation. J Neuroophthalmol. 2012 Dec; 32(4):335-7.
    View in: PubMed
  19. Mackay DD, Diamond EL, Klein JP. Widespread intracerebral metastases from prostate adenocarcinoma. Pract Neurol. 2012 Aug; 12(4):257-8.
    View in: PubMed
  20. Jindal JA, Seidman MA, Klein JP. A 48-year-old man with syncope and diffuse muscle twitches [paraneoplastic neuromyotonia]. The Neurohospitalist. 2012; 2(3):107-111.
  21. Wood BR, Klein JP, Lyons JL, Milner DA, Phillips RE, Schutten M, Folkerth RD, Ciarlini P, Henrich TJ, Johnson JA. HIV-2 encephalitis: case report and literature review. AIDS Patient Care STDS. 2012 Jul; 26(7):383-7.
    View in: PubMed
  22. Klein JP. Neuroimaging for the clinician. In "ACP Medicine, a publication of the American College of Physicians", Ed. Elizabeth G. Nabel. 2012.
  23. Lyons JL, Scripko PD, Mukerji SS, Awosika O, Shieh WJ, Zaki S, Deleon-Carnes M, Taylor C, Milner D, Johnson JA, Klein JP. Propionibacterium acnes brain abscess in a patient with HIV-1 infection. J Neurovirol. 2012 Apr; 18(2):148-50.
    View in: PubMed
  24. Bianchi MT, Klein JP, Caviness VS, Cash SS. Synchronizing bench and bedside: A clinical overview of networks and oscillations. In "Network Approaches to Diseases of the Brain: Clinical Applications in Neurology and Psychiatry", Ed. Matt T. Bianchi, Verne S. Caviness, Sydney S. Cash. 2012.
  25. Klein JP, Hsu L. Neuroimaging during pregnancy. Semin Neurol. 2011 Sep; 31(4):361-73.
    View in: PubMed
  26. Cvetanovich GL, Ramakrishnan P, Klein JP, Rao VR, Ropper AH. Reversible cerebral vasoconstriction syndrome in a patient taking citalopram and Hydroxycut: a case report. J Med Case Rep. 2011; 5:548.
    View in: PubMed
  27. Klein JP, Arora A, Neema M, Healy BC, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Stankiewicz JM, Cohen AB, Buckle GJ, Houtchens MK, Ceccarelli A, Dell'Oglio E, Guttmann CR, Alsop DC, Hackney DB, Bakshi R. A 3T MR imaging investigation of the topography of whole spinal cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2011 Jun-Jul; 32(6):1138-42.
    View in: PubMed
  28. Klein JP, Stankiewicz JM. Evaluator unfamiliarity is common and can affect medical student assessment. Proceedings of the Annual Meeting of the American Academy of Neurology, Honolulu, HI. 2011.
  29. Cohen AB, Neema M, Arora A, Dell'oglio E, Benedict RH, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Ceccarelli A, Klein JP, Stankiewicz JM, Houtchens MK, Buckle GJ, Alsop DC, Guttmann CR, Bakshi R. The relationships among MRI-defined spinal cord involvement, brain involvement, and disability in multiple sclerosis. J Neuroimaging. 2012 Apr; 22(2):122-8.
    View in: PubMed
  30. Klein JP. Demyelination vs. tumor infiltration in the brainstem. Journal Watch Neurology. 2010; 12(11):81.
  31. Cohen AB, Klein JP, Mukundan S. A guide to imaging for common neurological problems. BMJ. 2010; 341:c4113.
    View in: PubMed
  32. Klein JP, Cohen AB. Neuroimaging. In "Pocket Neurology", Ed. David M. Greer. 2010; 13-34.
  33. Cohen AB, Klein JP. Neuro-ophthalmology. In "Pocket Neurology", Ed. David M. Greer. 2010; 285-301.
  34. Klein JP. Diffusion-weighted imaging in normal pressure hydrocephalus. Journal Watch Neurology. 2010; 12(3):21-22.
  35. Krishnaswamy A, Klein JP, Kapadia SR. Clinical cerebrovascular anatomy. Catheter Cardiovasc Interv. 2010 Mar 1; 75(4):530-9.
    View in: PubMed
  36. Klein JP, Arora A, Neema M, Healy BC, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Stankiewicz JM, Cohen AB, Buckle GJ, Houtchens MK, Ceccarelli A, Dell'Oglio E, Guttmann CRG, Bakshi R. A 3T MRI investigation of the topography of whole spinal cord atrophy in multiple sclerosis. Program No. P03.111. Proceedings of the Annual Meeting of the American Academy of Neurology, Toronto, Ontario, CA. 2010.
  37. Klein JP, Ryther RC. Images in clinical medicine. Central nervous system hemorrhage. N Engl J Med. 2009 Oct 29; 361(18):1786.
    View in: PubMed
  38. Klein JP, Cohen AB, Kimberly WT, Shah AS, Leiderman YI, Cestari DM, Dinkin MJ. Diffusion-weighted magnetic resonance imaging of bilateral simultaneous optic nerve infarctions. Arch Neurol. 2009 Jan; 66(1):132-3.
    View in: PubMed
  39. Blumenfeld H, Lampert A, Klein JP, Mission J, Chen MC, Rivera M, Dib-Hajj S, Brennan AR, Hains BC, Waxman SG. Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis. Epilepsia. 2009 Jan; 50(1):44-55.
    View in: PubMed
  40. Blumenfeld H, Klein JP, Schridde U, Vestal M, Rice T, Khera DS, Bashyal C, Giblin K, Paul-Laughinghouse C, Wang F, Phadke A, Mission J, Agarwal RK, Englot DJ, Motelow J, Nersesyan H, Waxman SG, Levin AR. Early treatment suppresses the development of spike-wave epilepsy in a rat model. Epilepsia. 2008 Mar; 49(3):400-9.
    View in: PubMed
  41. Le T, Shivaram A, Klein J. First Aid Q&A for the USMLE Step 2 CK, 1st Edition. McGraw-Hill. 2007.
  42. Le T, Schabelman E, Shivaram A, Klein J. First Aid Cases for the USMLE Step 2 CK, 1st Edition. McGraw-Hill. 2006.
  43. Le T, Krause K, Klein J, Shivaram A. First Aid Q&A for the USMLE Step 1, 1st Edition. McGraw-Hill. 2006.
  44. Le T, Krause K, Klein J, Shivaram A. First Aid Cases for the USMLE Step 1, 1st Edition. McGraw-Hill. 2006.
  45. Klein JP, Kostina-O'Neil Y, Lesser RL. Neuro-ophthalmologic presentations of hemicrania continua. Am J Ophthalmol. 2006 Jan; 141(1):88-92.
    View in: PubMed
  46. Klein JP, Schridde U, Nersesyan H, Agarwal RK, Levin AR, Waxman SG, Blumenfeld H. Seizure blockade with ethosuximide normalizes Nav1.1, Nav1.6, and HCN1 channel expression in epileptic WAG/Rij rats. Epilepsia 46 Suppl. 8:110 (Abstract 2.056, Washington, D.C.). 2005.
  47. Klein JP, Schridde U, Nersesyan H, Agarwal RK, Levin AR, Waxman SG, Blumenfeld H. The effect of seizure blockade with ethosuximide on sodium and HCN1 channel expression in the epileptic WAG/Rij rat brain. Program No. 357.6. Society for Neuroscience Annual Meeting, Washington D.C. 2005.
  48. Klein JP. Activity-dependent modulation of neuronal sodium channel expression. Yale University Ph.D. Dissertation. 2004.
  49. Hains BC, Saab CY, Klein JP, Craner MJ, Waxman SG. Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J Neurosci. 2004 May 19; 24(20):4832-9.
    View in: PubMed
  50. Klein JP, Khera DS, Nersesyan H, Kimchi EY, Waxman SG, Blumenfeld H. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res. 2004 Mar 12; 1000(1-2):102-9.
    View in: PubMed
  51. Klein JP, Hains BC, Craner MJ, Black JA, Waxman SG. Apoptosis of vasopressinergic hypothalamic neurons in chronic diabetes mellitus. Neurobiol Dis. 2004 Mar; 15(2):221-8.
    View in: PubMed
  52. Bhushan V, Le T, Klein J, Shivaram A. First Aid for the USMLE Step 1, 14th Edition. McGraw-Hill. 2004.
  53. Klein JP, Tendi EA, Dib-Hajj SD, Fields RD, Waxman SG. Patterned electrical activity modulates sodium channel expression in sensory neurons. J Neurosci Res. 2003 Oct 15; 74(2):192-8.
    View in: PubMed
  54. Hains BC, Klein JP, Saab CY, Craner MJ, Black JA, Waxman SG. Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosci. 2003 Oct 1; 23(26):8881-92.
    View in: PubMed
  55. Klein JP, Waxman SG. The brain in diabetes: molecular changes in neurons and their implications for end-organ damage. Lancet Neurol. 2003 Sep; 2(9):548-54.
    View in: PubMed
  56. Klein JP, Jean-Baptiste M, Thompson JL, Bowers MB. A case report of hypomania following vagus nerve stimulation for refractory epilepsy. J Clin Psychiatry. 2003 Apr; 64(4):485.
    View in: PubMed
  57. Klein JP, Khera DS, Nersesyan H, Kimchi EY, Waxman SG, Blumenfeld H. Voltage-gated sodium channels Nav1.1 and Nav1.6 are overexpressed in cortical neurons in the absence epileptic WAG/Rij rat. Program No. 442.2. Society for Neuroscience Annual Meeting, New Orleans, LA. 2003.
  58. Klein JP, Khera DS, Nersesyan H, Kimchi EY, Waxman SG, Blumenfeld H. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Epilepsia 44 Suppl. 9:192 (Abstract 2.049, Boston, MA). 2003.
  59. Craner MJ, Klein JP, Renganathan M, Black JA, Waxman SG. Changes of sodium channel expression in experimental painful diabetic neuropathy. Ann Neurol. 2002 Dec; 52(6):786-92.
    View in: PubMed
  60. Craner MJ, Klein JP, Black JA, Waxman SG. Preferential expression of IGF-I in small DRG neurons and down-regulation following injury. Neuroreport. 2002 Sep 16; 13(13):1649-52.
    View in: PubMed
  61. Klein JP, Craner MJ, Cummins TR, Black JA, Waxman SG. Sodium channel expression in hypothalamic osmosensitive neurons in experimental diabetes. Neuroreport. 2002 Aug 7; 13(11):1481-4.
    View in: PubMed
  62. Shahabi S, Klein JP, Rinaudo PF. Primary psoas abscess complicating a normal vaginal delivery. Obstet Gynecol. 2002 May; 99(5 Pt 2):906-9.
    View in: PubMed
  63. Klein JP, Craner MJ, Cummins TR, Black JA, Waxman SG. Diabetes induces changes in sodium channel expression in hypothalamic osmosensitive neurons. Program No. 835.10. Society for Neuroscience Annual Meeting, Orlando, FL. 2002.
  64. Klein JP, Leete TH, Rubin H. A biomolecular implementation of logically reversible computation with minimal energy dissipation. Biosystems. 1999 Oct; 52(1-3):15-23.
    View in: PubMed
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