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Last Name
Institution

Sydney S. Cash, M.D.,Ph.D.

TitleAssociate Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Wacc-730
55 Fruit St
Boston MA 02114
Phone617/726-3311
Fax617/726-9250

 Mentoring 
 completed student projects
Laminar Microelectrode Analysis of Seizure Onset and Spread in the Epileptic Human Cortex
Summer, 06/20/11 - 08/12/11
Examination of the preictal period in patients with intractable epilepsy using in vivo microphysiological and multimodal studies
Summer, 07/01/06 - 06/01/07

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A Transition in Brain State during Propofol-Induced Unconsciousness. J Neurosci. 2014 Jan 15; 34(3):839-45.
    View in: PubMed
  2. Quinn BT, Carlson C, Doyle W, Cash SS, Devinsky O, Spence C, Halgren E, Thesen T. Intracranial Cortical Responses during Visual-Tactile Integration in Humans. J Neurosci. 2014 Jan 1; 34(1):171-81.
    View in: PubMed
  3. Karakis I, Pathmanathan JS, Chang R, Cook EF, Cash SS, Cole AJ. Prognostic value of EEG asymmetries for development of drug-resistance in drug-naïve patients with genetic generalized epilepsies. Clin Neurophysiol. 2014 Feb; 125(2):263-9.
    View in: PubMed
  4. Cash SS. Status epilepticus as a system disturbance: Is status epilepticus due to synchronization or desynchronization? Epilepsia. 2013 Sep; 54 Suppl 6:37-9.
    View in: PubMed
  5. Greer DM, Yang J, Scripko PD, Sims JR, Cash S, Wu O, Hafler JP, Schoenfeld DA, Furie KL. Clinical examination for prognostication in comatose cardiac arrest patients. Resuscitation. 2013 Nov; 84(11):1546-51.
    View in: PubMed
  6. Ahmed OJ, Cash SS. Finding synchrony in the desynchronized EEG: the history and interpretation of gamma rhythms. Front Integr Neurosci. 2013; 7:58.
    View in: PubMed
  7. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37.
    View in: PubMed
  8. Brandon Westover M, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. J Neurosci Methods. 2013 Sep 30; 219(1):131-41.
    View in: PubMed
  9. Jarosiewicz B, Masse NY, Bacher D, Cash SS, Eskandar E, Friehs G, Donoghue JP, Hochberg LR. Advantages of closed-loop calibration in intracortical brain-computer interfaces for people with tetraplegia. J Neural Eng. 2013 Aug; 10(4):046012.
    View in: PubMed
  10. Westover MB, Ching S, Shafi MM, Cash SS, Brown EN. Real-time segmentation and tracking of brain metabolic state in ICU EEG recordings of burst suppression. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul; 2013:7108-11.
    View in: PubMed
  11. Yücel MA, Selb J, Boas DA, Cash SS, Cooper RJ. Reducing motion artifacts for long-term clinical NIRS monitoring using collodion-fixed prism-based optical fibers. Neuroimage. 2014 Jan 15; 85 Pt 1:192-201.
    View in: PubMed
  12. Sukhotinsky I, Chan AM, Ahmed OJ, Rao VR, Gradinaru V, Ramakrishnan C, Deisseroth K, Majewska AK, Cash SS. Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model. PLoS One. 2013; 8(4):e62013.
    View in: PubMed
  13. Perge JA, Homer ML, Malik WQ, Cash S, Eskandar E, Friehs G, Donoghue JP, Hochberg LR. Intra-day signal instabilities affect decoding performance in an intracortical neural interface system. J Neural Eng. 2013 Jun; 10(3):036004.
    View in: PubMed
  14. Ferguson M, Bianchi MT, Sutter R, Rosenthal ES, Cash SS, Kaplan PW, Westover MB. Calculating the Risk Benefit Equation for Aggressive Treatment of Non-convulsive Status Epilepticus. Neurocrit Care. 2013 Apr; 18(2):216-27.
    View in: PubMed
  15. Westover MB, Bianchi MT, Shafi M, Hoch DB, Cole AJ, Chiappa K, Cash SS. Inferring seizure frequency from brief EEG recordings. J Clin Neurophysiol. 2013 Apr; 30(2):174-7.
    View in: PubMed
  16. Shafi MM, Brandon Westover M, Oberman L, Cash SS, Pascual-Leone A. Modulation of EEG functional connectivity networks in subjects undergoing repetitive transcranial magnetic stimulation. Brain Topogr. 2014 Jan; 27(1):172-91.
    View in: PubMed
  17. Thesen T, McDonald CR, Carlson C, Doyle W, Cash S, Sherfey J, Felsovalyi O, Girard H, Barr W, Devinsky O, Kuzniecky R, Halgren E. Sequential then interactive processing of letters and words in the left fusiform gyrus. Nat Commun. 2012 Dec 18; 3:1284.
    View in: PubMed
  18. Westover MB, Eiseman NA, Cash SS, Bianchi MT. Information theoretic quantification of diagnostic uncertainty. Open Med Inform J. 2012; 6:36-50.
    View in: PubMed
  19. Kramer MA, Truccolo W, Eden UT, Lepage KQ, Hochberg LR, Eskandar EN, Madsen JR, Lee JW, Maheshwari A, Halgren E, Chu CJ, Cash SS. Human seizures self-terminate across spatial scales via a critical transition. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):21116-21.
    View in: PubMed
  20. Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012 Dec 4; 109(49):E3377-86.
    View in: PubMed
  21. Shafi MM, Westover MB, Cole AJ, Kilbride RD, Hoch DB, Cash SS. Absence of early epileptiform abnormalities predicts lack of seizures on continuous EEG. Neurology. 2012 Oct 23; 79(17):1796-801.
    View in: PubMed
  22. Travis KE, Leonard MK, Chan AM, Torres C, Sizemore ML, Qu Z, Eskandar E, Dale AM, Elman JL, Cash SS, Halgren E. Independence of early speech processing from word meaning. Cereb Cortex. 2013 Oct; 23(10):2370-9.
    View in: PubMed
  23. Dehghani N, Hatsopoulos NG, Haga ZD, Parker RA, Greger B, Halgren E, Cash SS, Destexhe A. Avalanche Analysis from Multielectrode Ensemble Recordings in Cat, Monkey, and Human Cerebral Cortex during Wakefulness and Sleep. Front Physiol. 2012; 3:302.
    View in: PubMed
  24. Yang AI, Wang X, Doyle WK, Halgren E, Carlson C, Belcher TL, Cash SS, Devinsky O, Thesen T. Localization of dense intracranial electrode arrays using magnetic resonance imaging. Neuroimage. 2012 Oct 15; 63(1):157-65.
    View in: PubMed
  25. Hochberg LR, Bacher D, Jarosiewicz B, Masse NY, Simeral JD, Vogel J, Haddadin S, Liu J, Cash SS, van der Smagt P, Donoghue JP. Reach and grasp by people with tetraplegia using a neurally controlled robotic arm. Nature. 2012 May 17; 485(7398):372-5.
    View in: PubMed
  26. Bonjean M, Baker T, Bazhenov M, Cash S, Halgren E, Sejnowski T. Interactions between core and matrix thalamocortical projections in human sleep spindle synchronization. J Neurosci. 2012 Apr 11; 32(15):5250-63.
    View in: PubMed
  27. Greer DM, Yang J, Scripko PD, Sims JR, Cash S, Kilbride R, Wu O, Hafler JP, Schoenfeld DA, Furie KL. Clinical examination for outcome prediction in nontraumatic coma. Crit Care Med. 2012 Apr; 40(4):1150-6.
    View in: PubMed
  28. Sabolek HR, Swiercz WB, Lillis KP, Cash SS, Huberfeld G, Zhao G, Ste Marie L, Clemenceau S, Barsh G, Miles R, Staley KJ. A candidate mechanism underlying the variance of interictal spike propagation. J Neurosci. 2012 Feb 29; 32(9):3009-21.
    View in: PubMed
  29. Chu CJ, Kramer MA, Pathmanathan J, Bianchi MT, Westover MB, Wizon L, Cash SS. Emergence of stable functional networks in long-term human electroencephalography. J Neurosci. 2012 Feb 22; 32(8):2703-13.
    View in: PubMed
  30. Peyrache A, Dehghani N, Eskandar EN, Madsen JR, Anderson WS, Donoghue JA, Hochberg LR, Halgren E, Cash SS, Destexhe A. Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1731-6.
    View in: PubMed
  31. Kramer MA, Cash SS. Epilepsy as a disorder of cortical network organization. Neuroscientist. 2012 Aug; 18(4):360-72.
    View in: PubMed
  32. Westover MB, Cormier J, Bianchi MT, Shafi M, Kilbride R, Cole AJ, Cash SS. Revising the "Rule of Three" for inferring seizure freedom. Epilepsia. 2012 Feb; 53(2):368-76.
    View in: PubMed
  33. Chan AM, Baker JM, Eskandar E, Schomer D, Ulbert I, Marinkovic K, Cash SS, Halgren E. First-pass selectivity for semantic categories in human anteroventral temporal lobe. J Neurosci. 2011 Dec 7; 31(49):18119-29.
    View in: PubMed
  34. Kharbouch A, Shoeb A, Guttag J, Cash SS. An algorithm for seizure onset detection using intracranial EEG. Epilepsy Behav. 2011 Dec; 22 Suppl 1:S29-35.
    View in: PubMed
  35. Dykstra AR, Chan AM, Quinn BT, Zepeda R, Keller CJ, Cormier J, Madsen JR, Eskandar EN, Cash SS. Individualized localization and cortical surface-based registration of intracranial electrodes. Neuroimage. 2012 Feb 15; 59(4):3563-70.
    View in: PubMed
  36. Cash SS, Larvie M, Dalmau J. Case records of the Massachusetts General Hospital. Case 34-2011: A 75-year-old man with memory loss and partial seizures. N Engl J Med. 2011 Nov 10; 365(19):1825-33.
    View in: PubMed
  37. Kramer MA, Eden UT, Lepage KQ, Kolaczyk ED, Bianchi MT, Cash SS. Emergence of persistent networks in long-term intracranial EEG recordings. J Neurosci. 2011 Nov 2; 31(44):15757-67.
    View in: PubMed
  38. Bianchi MT, Eiseman NA, Cash SS, Mietus J, Peng CK, Thomas RJ. Probabilistic sleep architecture models in patients with and without sleep apnea. J Sleep Res. 2012 Jun; 21(3):330-41.
    View in: PubMed
  39. Dykstra AR, Halgren E, Thesen T, Carlson CE, Doyle W, Madsen JR, Eskandar EN, Cash SS. Widespread Brain Areas Engaged during a Classical Auditory Streaming Task Revealed by Intracranial EEG. Front Hum Neurosci. 2011; 5:74.
    View in: PubMed
  40. Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS. Single-neuron dynamics in human focal epilepsy. Nat Neurosci. 2011 May; 14(5):635-41.
    View in: PubMed
  41. Dehghani N, Cash SS, Halgren E. Emergence of synchronous EEG spindles from asynchronous MEG spindles. Hum Brain Mapp. 2011 Dec; 32(12):2217-27.
    View in: PubMed
  42. Chu-Shore CJ, Kramer MA, Bianchi MT, Caviness VS, Cash SS. Network analysis: applications for the developing brain. J Child Neurol. 2011 Apr; 26(4):488-500.
    View in: PubMed
  43. Chan AM, Halgren E, Marinkovic K, Cash SS. Decoding word and category-specific spatiotemporal representations from MEG and EEG. Neuroimage. 2011 Feb 14; 54(4):3028-39.
    View in: PubMed
  44. Dehghani N, Bédard C, Cash SS, Halgren E, Destexhe A. Comparative power spectral analysis of simultaneous elecroencephalographic and magnetoencephalographic recordings in humans suggests non-resistive extracellular media. J Comput Neurosci. 2010 Dec; 29(3):405-21.
    View in: PubMed
  45. Kramer MA, Eden UT, Kolaczyk ED, Zepeda R, Eskandar EN, Cash SS. Coalescence and fragmentation of cortical networks during focal seizures. J Neurosci. 2010 Jul 28; 30(30):10076-85.
    View in: PubMed
  46. Csercsa R, Dombovári B, Fabó D, Wittner L, Eross L, Entz L, Sólyom A, Rásonyi G, Szucs A, Kelemen A, Jakus R, Juhos V, Grand L, Magony A, Halász P, Freund TF, Maglóczky Z, Cash SS, Papp L, Karmos G, Halgren E, Ulbert I. Laminar analysis of slow wave activity in humans. Brain. 2010 Sep; 133(9):2814-29.
    View in: PubMed
  47. Dehghani N, Cash SS, Halgren E. Topographical frequency dynamics within EEG and MEG sleep spindles. Clin Neurophysiol. 2011 Feb; 122(2):229-35.
    View in: PubMed
  48. McDonald CR, Thesen T, Carlson C, Blumberg M, Girard HM, Trongnetrpunya A, Sherfey JS, Devinsky O, Kuzniecky R, Dolye WK, Cash SS, Leonard MK, Hagler DJ, Dale AM, Halgren E. Multimodal imaging of repetition priming: Using fMRI, MEG, and intracranial EEG to reveal spatiotemporal profiles of word processing. Neuroimage. 2010 Nov 1; 53(2):707-17.
    View in: PubMed
  49. Dehghani N, Cash SS, Chen CC, Hagler DJ, Huang M, Dale AM, Halgren E. Divergent cortical generators of MEG and EEG during human sleep spindles suggested by distributed source modeling. PLoS One. 2010; 5(7):e11454.
    View in: PubMed
  50. Bianchi MT, Cash SS, Mietus J, Peng CK, Thomas R. Obstructive sleep apnea alters sleep stage transition dynamics. PLoS One. 2010; 5(6):e11356.
    View in: PubMed
  51. Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C, Devinsky O, Kuzniecky R, Doyle WK, Madsen JR, Schomer DL, Mehta AD, Brown EN, Hochberg LR, Ulbert I, Halgren E, Cash SS. Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain. 2010 Jun; 133(Pt 6):1668-81.
    View in: PubMed
  52. Dehghani N, Cash SS, Rossetti AO, Chen CC, Halgren E. Magnetoencephalography demonstrates multiple asynchronous generators during human sleep spindles. J Neurophysiol. 2010 Jul; 104(1):179-88.
    View in: PubMed
  53. Bangera NB, Schomer DL, Dehghani N, Ulbert I, Cash S, Papavasiliou S, Eisenberg SR, Dale AM, Halgren E. Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution. J Comput Neurosci. 2010 Dec; 29(3):371-87.
    View in: PubMed
  54. Zheng Y, Moussally J, Cash SS, Karnam HB, Cole AJ. Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: behavioral, physiological and histological studies. Neuropharmacology. 2010 Mar-Apr; 58(4-5):793-8.
    View in: PubMed
  55. Sahin NT, Pinker S, Cash SS, Schomer D, Halgren E. Sequential processing of lexical, grammatical, and phonological information within Broca's area. Science. 2009 Oct 16; 326(5951):445-9.
    View in: PubMed
  56. Kramer MA, Eden UT, Cash SS, Kolaczyk ED. Network inference with confidence from multivariate time series. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jun; 79(6 Pt 1):061916.
    View in: PubMed
  57. Cash SS, Halgren E, Dehghani N, Rossetti AO, Thesen T, Wang C, Devinsky O, Kuzniecky R, Doyle W, Madsen JR, Bromfield E, Eross L, Halász P, Karmos G, Csercsa R, Wittner L, Ulbert I. The human K-complex represents an isolated cortical down-state. Science. 2009 May 22; 324(5930):1084-7.
    View in: PubMed
  58. Gow DW, Keller CJ, Eskandar E, Meng N, Cash SS. Parallel versus serial processing dependencies in the perisylvian speech network: a Granger analysis of intracranial EEG data. Brain Lang. 2009 Jul; 110(1):43-8.
    View in: PubMed
  59. Keller CJ, Cash SS, Narayanan S, Wang C, Kuzniecky R, Carlson C, Devinsky O, Thesen T, Doyle W, Sassaroli A, Boas DA, Ulbert I, Halgren E. Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex. J Neurosci Methods. 2009 May 15; 179(2):208-18.
    View in: PubMed
  60. Dauwels J, Eskandar E, Cash S. Localization of seizure onset area from intracranial non-seizure EEG by exploiting locally enhanced synchrony. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:2180-3.
    View in: PubMed
  61. Bianchi MT, Pathmanathan J, Cash SS. From ion channels to complex networks: magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy. Med Hypotheses. 2009 Mar; 72(3):297-305.
    View in: PubMed
  62. Costello DJ, Shields DC, Cash SS, Eskandar EN, Cosgrove GR, Cole AJ. Consideration of epilepsy surgery in adults should be independent of age. Clin Neurol Neurosurg. 2009 Apr; 111(3):240-5.
    View in: PubMed
  63. Bianchi MT, Alexander BM, Cash SS. Incorporating uncertainty into medical decision making: an approach to unexpected test results. Med Decis Making. 2009 Jan-Feb; 29(1):116-24.
    View in: PubMed
  64. Meng, N., Cash, S. S., Thesen, T., Wang, C., Schomer, D. L., Devinsky, O., Carlson, C., Kuzniecky, R., Doyle, W., Madsen, J., Bromfield, E.B., Ulbert, I., Halgren, E. Generation of the Human Alpha Rhythm. 2008; Submitted.
  65. Costello, D.J. Shields, D.C. Cash, S.S. Eskandar, E.N. Cosgrove, G.R. Cole, A.J. Consideration of Epilepsy Surgery in Adults Should be Independent of Age. Journal of Neurology, Neurosurgery, and Psychiatry. 2008; Submitted.
  66. Bianchi, M.T., Pathmanathan, J., Cash, S.S. From ion channels to complex networks: magic bullets versus magic shotgun approaches to anticonvulsant pharmacotherapy. 2008; Submitted.
  67. Bianchi, MT, Alexander, BM, Cash, SS. Incorporating uncertainty into medical decision making: An approach to unexpected test results. Medical Decision Making. 2008; In Press.
  68. Cash, SS, Halgren, E, Dehghani, N, Rossetti, AO, Bromfield, EB, Thesen, T, Wang, C, Devinsky, O, Kuzniecky, R, Doyle, W, Madsen, JR, Eross, L, Halasz, P, Karmos, G, Ulbert, I. The Human K-Complex Represents an Induced Cortical Down State. 2007; Submitted.
  69. Kao AY, Munandar R, Ferrara SL, Systrom DM, Sheridan RL, Cash SS, Ryan ET. Case records of the Massachusetts General Hospital. Case 19-2005. A 17-year-old girl with respiratory distress and hemiparesis after surviving a tsunami. N Engl J Med. 2005 Jun 23; 352(25):2628-36.
    View in: PubMed
  70. Yuste R, Majewska A, Cash SS, Denk W. Mechanisms of calcium influx into hippocampal spines: heterogeneity among spines, coincidence detection by NMDA receptors, and optical quantal analysis. J Neurosci. 1999 Mar 15; 19(6):1976-87.
    View in: PubMed
  71. Cash S, Yuste R. Linear summation of excitatory inputs by CA1 pyramidal neurons. Neuron. 1999 Feb; 22(2):383-94.
    View in: PubMed
  72. Yuste, R., Majewska, A. and Cash, S.S. From Form to Function: Functional Exploration of Dendritic Morphology in CA1 pyramidal neurons. Develop. Psych. 1999; 16(3):315-316.
  73. Sydney S. Cash. Neuronal Structure and Function: Effects of Axonal and Dendritic Morphology on Signal Propagation and Integration in Vertebrate Neurons. 1998.
  74. Cash S, Yuste R. Input summation by cultured pyramidal neurons is linear and position-independent. J Neurosci. 1998 Jan 1; 18(1):10-5.
    View in: PubMed
  75. Lowen SB, Cash SS, Poo M, Teich MC. Quantal neurotransmitter secretion rate exhibits fractal behavior. J Neurosci. 1997 Aug 1; 17(15):5666-77.
    View in: PubMed
  76. Lowen, S., Cash, S.S., Poo, M-M., Teich, M.C. Neuronal Exocytosis Exhibits Fractal Behavior. Computational Neuroscience. 1997; 17(15):5666-5677.
  77. Cash S, Zucker RS, Poo MM. Spread of synaptic depression mediated by presynaptic cytoplasmic signaling. Science. 1996 May 17; 272(5264):998-1001.
    View in: PubMed
  78. Cash S, Dan Y, Poo MM, Zucker R. Postsynaptic elevation of calcium induces persistent depression of developing neuromuscular synapses. Neuron. 1996 Apr; 16(4):745-54.
    View in: PubMed
  79. Cash, S., Poo, M-M. Presynaptic differentiation and retrograde signaling during the early phase of synaptogenesis. Seminars in Developmental Biology. 1995; 6:185-193.
  80. Keshishian H, Chiba A, Chang TN, Halfon MS, Harkins EW, Jarecki J, Wang L, Anderson M, Cash S, Halpern ME, et al. Cellular mechanisms governing synaptic development in Drosophila melanogaster. J Neurobiol. 1993 Jun; 24(6):757-87.
    View in: PubMed
  81. Chiba A, Hing H, Cash S, Keshishian H. Growth cone choices of Drosophila motoneurons in response to muscle fiber mismatch. J Neurosci. 1993 Feb; 13(2):714-32.
    View in: PubMed
  82. Cash S, Chiba A, Keshishian H. Alternate neuromuscular target selection following the loss of single muscle fibers in Drosophila. J Neurosci. 1992 Jun; 12(6):2051-64.
    View in: PubMed
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