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Warren Myron Zapol, M.D.

TitleReginald Jenney Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Anaesthesia & Critical Care, Thier 503
55 Fruit St
Boston MA 02114
Phone617/726-3030
Fax617/643-5767
Other Positions
TitleMember of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


 Mentoring 
 current student opportunities
Available: 08/31/12, Expires: 08/31/14

The student will participate in a randomized clinical trial of inhaled NO in children in Mbarara, Uganda with severe cerebral malaria. We have thus far entered 30 children in this randomized trial. We expect to enter about 93 children. We expect to find a signal of reduced inflammation and organ dysfunction in this pilot trial. A medical student can help us to collect the data, analyze the data and understand the effect of inhaled NO in this common and often lethal disease of children. The student will have the opportunity to travel to Uganda.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Beloiartsev A, Baron DM, Yu B, Bloch KD, Zapol WM. Hemoglobin infusion does not alter murine pulmonary vascular tone. Nitric Oxide. 2013 Apr 1; 30:1-8.
    View in: PubMed
  2. Lei C, Yu B, Shahid M, Beloiartsev A, Bloch KD, Zapol WM. Inhaled nitric oxide attenuates the adverse effects of transfusing stored syngeneic erythrocytes in mice with endothelial dysfunction after hemorrhagic shock. Anesthesiology. 2012 Dec; 117(6):1190-202.
    View in: PubMed
  3. Bergmark B, Bergmark R, Beaudrap PD, Boum Y, Mwanga-Amumpaire J, Carroll R, Zapol W. Inhaled nitric oxide and cerebral malaria: basis of a strategy for buying time for pharmacotherapy. Pediatr Infect Dis J. 2012 Dec; 31(12):e250-4.
    View in: PubMed
  4. Berra L, Coppadoro A, Yu B, Lei C, Spagnolli E, Steinbicker AU, Bloch KD, Lin T, Sammy FY, Warren HS, Fernandez BO, Feelisch M, Dzik WH, Stowell CP, Zapol WM. Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology. 2012 Jul; 117(1):56-63.
    View in: PubMed
  5. Vaporidi K, Vergadi E, Kaniaris E, Hatziapostolou M, Lagoudaki E, Georgopoulos D, Zapol WM, Bloch KD, Iliopoulos D. Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1; 303(3):L199-207.
    View in: PubMed
  6. Baron DM, Yu B, Lei C, Bagchi A, Beloiartsev A, Stowell CP, Steinbicker AU, Malhotra R, Bloch KD, Zapol WM. Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide. Anesthesiology. 2012 Mar; 116(3):637-47.
    View in: PubMed
  7. Yu B, Lei C, Baron DM, Steinbicker AU, Bloch KD, Zapol WM. Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice. Transfusion. 2012 Jul; 52(7):1410-22.
    View in: PubMed
  8. Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):613-22.
    View in: PubMed
  9. Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, Liles WC, Zapol WM, Kain KC. Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. PLoS One. 2011; 6(11):e27714.
    View in: PubMed
  10. Lui FE, Yu B, Baron DM, Lei C, Zapol WM, Kluger R. Hemodynamic responses to a hemoglobin bis-tetramer and its polyethylene glycol conjugate. Transfusion. 2012 May; 52(5):974-82.
    View in: PubMed
  11. Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM. Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology. 2011 Nov; 115(5):1012-21.
    View in: PubMed
  12. Petersen B, Austen KF, Bloch KD, Hotta Y, Ichinose F, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11.
    View in: PubMed
  13. Jiang Y, Bao FP, Liang Y, Kimball WR, Liu Y, Zapol WM, Kacmarek RM. Effectiveness of breathing through nasal and oral routes in unconscious apneic adult human subjects: a prospective randomized crossover trial. Anesthesiology. 2011 Jul; 115(1):129-35.
    View in: PubMed
  14. Steinbicker AU, Liu H, Jiramongkolchai K, Malhotra R, Choe EY, Busch CJ, Graveline AR, Kao SM, Nagasaka Y, Ichinose F, Buys ES, Brouckaert P, Zapol WM, Bloch KD. Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Nitric Oxide. 2011 Oct 30; 25(3):294-302.
    View in: PubMed
  15. Zapol WM. Life at the frontier: the third annual John W. Severinghaus lecture on translational science. Anesthesiology. 2011 Apr; 114(4):771-81.
    View in: PubMed
  16. Derwall M, Francis RC, Kida K, Bougaki M, Crimi E, Adrie C, Zapol WM, Ichinose F. Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects. Crit Care. 2011; 15(1):R51.
    View in: PubMed
  17. Nagasaka Y, Buys ES, Spagnolli E, Steinbicker AU, Hayton SR, Rauwerdink KM, Brouckaert P, Zapol WM, Bloch KD. Soluble guanylate cyclase-a1 is required for the cardioprotective effects of inhaled nitric oxide. Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1477-83.
    View in: PubMed
  18. Shahid M, Shen L, Seldin DC, Lu B, Ustyugova IV, Chen X, Zapol WM, Wu MX. Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells. Hypertension. 2010 Oct; 56(4):705-12.
    View in: PubMed
  19. Vaporidi K, Francis RC, Bloch KD, Zapol WM. Nitric oxide synthase 3 contributes to ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2010 Aug; 299(2):L150-9.
    View in: PubMed
  20. Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology. 2010 Mar; 112(3):586-94.
    View in: PubMed
  21. Yu B, Bloch KD, Zapol WM. Hemoglobin-based red blood cell substitutes and nitric oxide. Trends Cardiovasc Med. 2009 Apr; 19(3):103-7.
    View in: PubMed
  22. Yu B, Volpato GP, Chang K, Bloch KD, Zapol WM. Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology. 2009 Jan; 110(1):113-22.
    View in: PubMed
  23. Nagasaka Y, Fernandez BO, Garcia-Saura MF, Petersen B, Ichinose F, Bloch KD, Feelisch M, Zapol WM. Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology. 2008 Oct; 109(4):675-82.
    View in: PubMed
  24. Kitch BT, Cooper JB, Zapol WM, Marder JE, Karson A, Hutter M, Campbell EG. Handoffs causing patient harm: a survey of medical and surgical house staff. Jt Comm J Qual Patient Saf. 2008 Oct; 34(10):563-70.
    View in: PubMed
  25. Fitzsimons MG, Baker KH, Lowenstein E, Zapol WM. Random drug testing to reduce the incidence of addiction in anesthesia residents: preliminary results from one program. Anesth Analg. 2008 Aug; 107(2):630-5.
    View in: PubMed
  26. Liang Y, Kimball WR, Kacmarek RM, Zapol WM, Jiang Y. Nasal ventilation is more effective than combined oral-nasal ventilation during induction of general anesthesia in adult subjects. Anesthesiology. 2008 Jun; 108(6):998-1003.
    View in: PubMed
  27. Falke KJ, Busch T, Hoffmann O, Liggins GC, Liggins J, Mohnhaupt R, Roberts JD, Stanek K, Zapol WM. Breathing pattern, CO2 elimination and the absence of exhaled NO in freely diving Weddell seals. Respir Physiol Neurobiol. 2008 Jun 30; 162(1):85-92.
    View in: PubMed
  28. Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation. 2008 Apr 15; 117(15):1982-90.
    View in: PubMed
  29. Volpato GP, Searles R, Yu B, Scherrer-Crosbie M, Bloch KD, Ichinose F, Zapol WM. Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiology. 2008 Apr; 108(4):659-68.
    View in: PubMed
  30. Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J. Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L300-8.
    View in: PubMed
  31. Evgenov OV, Kohane DS, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 1; 176(11):1138-45.
    View in: PubMed
  32. Liu R, Hotta Y, Graveline AR, Evgenov OV, Buys ES, Bloch KD, Ichinose F, Zapol WM. Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Nov; 293(5):L1300-5.
    View in: PubMed
  33. Raher MJ, Thibault H, Poh KK, Liu R, Halpern EF, Derumeaux G, Ichinose F, Zapol WM, Bloch KD, Picard MH, Scherrer-Crosbie M. In vivo characterization of murine myocardial perfusion with myocardial contrast echocardiography: validation and application in nitric oxide synthase 3 deficient mice. Circulation. 2007 Sep 11; 116(11):1250-7.
    View in: PubMed
  34. Bloch KD, Ichinose F, Roberts JD, Zapol WM. Inhaled NO as a therapeutic agent. Cardiovasc Res. 2007 Jul 15; 75(2):339-48.
    View in: PubMed
  35. Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H620-7.
    View in: PubMed
  36. Culley DJ, Crosby G, Xie Z, Vacanti CA, Kitz RJ, Zapol WM. Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery. Anesthesiology. 2007 Apr; 106(4):836-42.
    View in: PubMed
  37. Zapol W. A vision for International Polar year 2007-2008. Alaska Med. 2007; 49(2 Suppl):8-10.
    View in: PubMed
  38. Jiang Y, Wain JC, Chang AW, Zapol WM, Xie Z. Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery. Anesth Analg. 2006 Aug; 103(2):312-5, table of contents.
    View in: PubMed
  39. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H379-84.
    View in: PubMed
  40. Hataishi R, Zapol WM, Bloch KD, Ichinose F. Inhaled nitric oxide does not reduce systemic vascular resistance in mice. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1826-9.
    View in: PubMed
  41. Evgenov OV, Busch CJ, Evgenov NV, Liu R, Petersen B, Falkowski GE, Petho B, Vas A, Bloch KD, Zapol WM, Ichinose F. Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L723-L729.
    View in: PubMed
  42. Falkowski PG, Katz ME, Milligan AJ, Fennel K, Cramer BS, Aubry MP, Berner RA, Novacek MJ, Zapol WM. The rise of oxygen over the past 205 million years and the evolution of large placental mammals. Science. 2005 Sep 30; 309(5744):2202-4.
    View in: PubMed
  43. Lepore JJ, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Combined administration of intravenous dipyridamole and inhaled nitric oxide to assess reversibility of pulmonary arterial hypertension in potential cardiac transplant recipients. J Heart Lung Transplant. 2005 Nov; 24(11):1950-6.
    View in: PubMed
  44. Caironi P, Ichinose F, Liu R, Jones RC, Bloch KD, Zapol WM. 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Am J Respir Crit Care Med. 2005 Aug 1; 172(3):334-43.
    View in: PubMed
  45. Lepore JJ, Maroo A, Bigatello LM, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest. 2005 May; 127(5):1647-53.
    View in: PubMed
  46. Evgenov OV, Ichinose F, Evgenov NV, Gnoth MJ, Falkowski GE, Chang Y, Bloch KD, Zapol WM. Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs. Circulation. 2004 Oct 12; 110(15):2253-9.
    View in: PubMed
  47. Zapol WM. Clifford J. Woolf, M.B., B,Ch., Ph.D. Recipient of the 2004 Excellence in Research Award. Anesthesiology. 2004 Oct; 101(4):820-3.
    View in: PubMed
  48. Inglessis I, Shin JT, Lepore JJ, Palacios IF, Zapol WM, Bloch KD, Semigran MJ. Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock. J Am Coll Cardiol. 2004 Aug 18; 44(4):793-8.
    View in: PubMed
  49. Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1241-7.
    View in: PubMed
  50. Ichinose F, Roberts JD, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation. 2004 Jun 29; 109(25):3106-11.
    View in: PubMed
  51. Ichinose F, Hataishi R, Wu JC, Kawai N, Rodrigues AC, Mallari C, Post JM, Parkinson JF, Picard MH, Bloch KD, Zapol WM. A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2524-30.
    View in: PubMed
  52. Baboolal HA, Ichinose F, Ullrich R, Kawai N, Bloch KD, Zapol WM. Reactive oxygen species scavengers attenuate endotoxin-induced impairment of hypoxic pulmonary vasoconstriction in mice. Anesthesiology. 2002 Nov; 97(5):1227-33.
    View in: PubMed
  53. Hataishi R, Kobayashi H, Takahashi Y, Hirano S, Zapol WM, Jones RC. Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats. Anesthesiology. 2002 Oct; 97(4):887-95.
    View in: PubMed
  54. Lepore JJ, Maroo A, Pereira NL, Ginns LC, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension. Am J Cardiol. 2002 Sep 15; 90(6):677-80.
    View in: PubMed
  55. Ichinose F, Ullrich R, Sapirstein A, Jones RC, Bonventre JV, Serhan CN, Bloch KD, Zapol WM. Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction. J Clin Invest. 2002 Jun; 109(11):1493-500.
    View in: PubMed
  56. Raveh Y, Ichinose F, Orbach P, Bloch KD, Zapol WM. Radical scavengers protect murine lungs from endotoxin-induced hyporesponsiveness to inhaled nitric oxide. Anesthesiology. 2002 Apr; 96(4):926-33.
    View in: PubMed
  57. Scherrer-Crosbie M, Ullrich R, Bloch KD, Nakajima H, Nasseri B, Aretz HT, Lindsey ML, Vançon AC, Huang PL, Lee RT, Zapol WM, Picard MH. Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice. Circulation. 2001 Sep 11; 104(11):1286-91.
    View in: PubMed
  58. Scherrer-Crosbie M, Streckenbach SC, Zapol WM. Acute cor pulmonale in acute respiratory distress syndrome: a dreaded complication of the past? Crit Care Med. 2001 Aug; 29(8):1641-2.
    View in: PubMed
  59. Schmidt U, Han RO, DiSalvo TG, Guerrero JL, Gold HK, Zapol WM, Bloch KD, Semigran MJ. Cessation of platelet-mediated cyclic canine coronary occlusion after thrombolysis by combining nitric oxide inhalation with phosphodiesterase-5 inhibition. J Am Coll Cardiol. 2001 Jun 1; 37(7):1981-8.
    View in: PubMed
  60. Ichinose F, Erana-Garcia J, Hromi J, Raveh Y, Jones R, Krim L, Clark MW, Winkler JD, Bloch KD, Zapol WM. Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension. Crit Care Med. 2001 May; 29(5):1000-5.
    View in: PubMed
  61. Ichinose F, Zapol WM, Sapirstein A, Ullrich R, Tager AM, Coggins K, Jones R, Bloch KD. Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice. Circ Res. 2001 Apr 27; 88(8):832-8.
    View in: PubMed
  62. Kobayashi H, Hataishi R, Mitsufuji H, Tanaka M, Jacobson M, Tomita T, Zapol WM, Jones RC. Antiinflammatory properties of inducible nitric oxide synthase in acute hyperoxic lung injury. Am J Respir Cell Mol Biol. 2001 Apr; 24(4):390-7.
    View in: PubMed
  63. Cockrill BA, Kacmarek RM, Fifer MA, Bigatello LM, Ginns LC, Zapol WM, Semigran MJ. Comparison of the effects of nitric oxide, nitroprusside, and nifedipine on hemodynamics and right ventricular contractility in patients with chronic pulmonary hypertension. Chest. 2001 Jan; 119(1):128-36.
    View in: PubMed
  64. Holzmann A, Manktelow C, Weimann J, Bloch KD, Zapol WM. Inhibition of lung phosphodiesterase improves responsiveness to inhaled nitric oxide in isolated-perfused lungs from rats challenged with endotoxin. Intensive Care Med. 2001 Jan; 27(1):251-7.
    View in: PubMed
  65. Steudel W, Kirmse M, Weimann J, Ullrich R, Hromi J, Zapol WM. Exhaled nitric oxide production by nitric oxide synthase-deficient mice. Am J Respir Crit Care Med. 2000 Oct; 162(4 Pt 1):1262-7.
    View in: PubMed
  66. Ullrich R, Scherrer-Crosbie M, Bloch KD, Ichinose F, Nakajima H, Picard MH, Zapol WM, Quezado ZM. Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice. Circulation. 2000 Sep 19; 102(12):1440-6.
    View in: PubMed
  67. Adrie C, Holzmann A, Hirani WM, Zapol WM, Hurford WE. Effects of intravenous Zaprinast and inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of acute respiratory distress syndrome. Anesthesiology. 2000 Aug; 93(2):422-30.
    View in: PubMed
  68. Roberts JD, Chiche JD, Weimann J, Steudel W, Zapol WM, Bloch KD. Nitric oxide inhalation decreases pulmonary artery remodeling in the injured lungs of rat pups. Circ Res. 2000 Jul 21; 87(2):140-5.
    View in: PubMed
  69. Weimann J, Ullrich R, Hromi J, Fujino Y, Clark MW, Bloch KD, Zapol WM. Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology. 2000 Jun; 92(6):1702-12.
    View in: PubMed
  70. Roberts JD, Zapol WM. Inhaled nitric oxide. Semin Perinatol. 2000 Feb; 24(1):55-8.
    View in: PubMed
  71. Weimann J, Bloch KD, Takata M, Steudel W, Zapol WM. Congenital NOS2 deficiency protects mice from LPS-induced hyporesponsiveness to inhaled nitric oxide. Anesthesiology. 1999 Dec; 91(6):1744-53.
    View in: PubMed
  72. Sheridan RL, Zapol WM, Ritz RH, Tompkins RG. Low-dose inhaled nitric oxide in acutely burned children with profound respiratory failure. Surgery. 1999 Nov; 126(5):856-62.
    View in: PubMed
  73. Ullrich R, Bloch KD, Ichinose F, Steudel W, Zapol WM. Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest. 1999 Nov; 104(10):1421-9.
    View in: PubMed
  74. Steudel W, Hurford WE, Zapol WM. Inhaled nitric oxide: basic biology and clinical applications. Anesthesiology. 1999 Oct; 91(4):1090-121.
    View in: PubMed
  75. Scherrer-Crosbie M, Steudel W, Hunziker PR, Liel-Cohen N, Ullrich R, Zapol WM, Picard MH. Three-dimensional echocardiographic assessment of left ventricular wall motion abnormalities in mouse myocardial infarction. J Am Soc Echocardiogr. 1999 Oct; 12(10):834-40.
    View in: PubMed
  76. Scherrer-Crosbie M, Steudel W, Ullrich R, Hunziker PR, Liel-Cohen N, Newell J, Zaroff J, Zapol WM, Picard MH. Echocardiographic determination of risk area size in a murine model of myocardial ischemia. Am J Physiol. 1999 Sep; 277(3 Pt 2):H986-92.
    View in: PubMed
  77. Holzmann A, Manktelow C, Taut FJ, Bloch KD, Zapol WM. Inhibition of nitric oxide synthase prevents hyporesponsiveness to inhaled nitric oxide in lungs from endotoxin-challenged rats. Anesthesiology. 1999 Jul; 91(1):215-21.
    View in: PubMed
  78. Scherrer-Crosbie M, Steudel W, Hunziker PR, Foster GP, Garrido L, Liel-Cohen N, Zapol WM, Picard MH. Determination of right ventricular structure and function in normoxic and hypoxic mice: a transesophageal echocardiographic study. Circulation. 1998 Sep 8; 98(10):1015-21.
    View in: PubMed
  79. Koelling TM, Kirmse M, Di Salvo TG, Dec GW, Zapol WM, Semigran MJ. Inhaled nitric oxide improves exercise capacity in patients with severe heart failure and right ventricular dysfunction. Am J Cardiol. 1998 Jun 15; 81(12):1494-7.
    View in: PubMed
  80. Weimann J, Bauer H, Bigatello L, Bloch KD, Martin E, Zapol WM. ABO blood group and inhaled nitric oxide in acute respiratory distress syndrome. Lancet. 1998 Jun 13; 351(9118):1786-7.
    View in: PubMed
  81. Steudel W, Scherrer-Crosbie M, Bloch KD, Weimann J, Huang PL, Jones RC, Picard MH, Zapol WM. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J Clin Invest. 1998 Jun 1; 101(11):2468-77.
    View in: PubMed
  82. Sanchez LS, de la Monte SM, Filippov G, Jones RC, Zapol WM, Bloch KD. Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res. 1998 Feb; 43(2):163-8.
    View in: PubMed
  83. Adrie C, Ichinose F, Holzmann A, Keefer L, Hurford WE, Zapol WM. Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension. J Appl Physiol. 1998 Feb; 84(2):435-41.
    View in: PubMed
  84. Ichinose F, Adrie C, Hurford WE, Bloch KD, Zapol WM. Selective pulmonary vasodilation induced by aerosolized zaprinast. Anesthesiology. 1998 Feb; 88(2):410-6.
    View in: PubMed
  85. Adrie C, Hirani WM, Holzmann A, Keefer L, Zapol WM, Hurford WE. Selective pulmonary vasodilation by intravenous infusion of an ultrashort half-life nucleophile/nitric oxide adduct. Anesthesiology. 1998 Jan; 88(1):190-5.
    View in: PubMed
  86. Zapol WM. Nitric oxide inhalation in acute respiratory distress syndrome: it works, but can we prove it? Crit Care Med. 1998 Jan; 26(1):2-3.
    View in: PubMed
  87. Head CA, Brugnara C, Martinez-Ruiz R, Kacmarek RM, Bridges KR, Kuter D, Bloch KD, Zapol WM. Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J Clin Invest. 1997 Sep 1; 100(5):1193-8.
    View in: PubMed
  88. Steudel W, Ichinose F, Huang PL, Hurford WE, Jones RC, Bevan JA, Fishman MC, Zapol WM. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res. 1997 Jul; 81(1):34-41.
    View in: PubMed
  89. Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med. 1997 Feb 27; 336(9):605-10.
    View in: PubMed
  90. Holzmann A, Bloch KD, Sanchez LS, Filippov G, Zapol WM. Hyporesponsiveness to inhaled nitric oxide in isolated, perfused lungs from endotoxin-challenged rats. Am J Physiol. 1996 Dec; 271(6 Pt 1):L981-6.
    View in: PubMed
  91. Saavedra JE, Southan GJ, Davies KM, Lundell A, Markou C, Hanson SR, Adrie C, Hurford WE, Zapol WM, Keefer LK. Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor. J Med Chem. 1996 Oct 25; 39(22):4361-5.
    View in: PubMed
  92. Adrie C, Bloch KD, Moreno PR, Hurford WE, Guerrero JL, Holt R, Zapol WM, Gold HK, Semigran MJ. Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation. 1996 Oct 15; 94(8):1919-26.
    View in: PubMed
  93. Bigatello LM, Zapol WM. New approaches to acute lung injury. Br J Anaesth. 1996 Jul; 77(1):99-109.
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  94. Kobayashi H, Tanaka N, Winkler M, Zapol WM. Combined effects of NO inhalation and intravenous PGF2 alpha on pulmonary circulation and gas exchange in an ovine ARDS model. Intensive Care Med. 1996 Jul; 22(7):656-63.
    View in: PubMed
  95. Lee JS, Adrie C, Jacob HJ, Roberts JD, Zapol WM, Bloch KD. Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res. 1996 Feb; 78(2):337-42.
    View in: PubMed
  96. Hurford WE, Hochachka PW, Schneider RC, Guyton GP, Stanek KS, Zapol DG, Liggins GC, Zapol WM. Splenic contraction, catecholamine release, and blood volume redistribution during diving in the Weddell seal. J Appl Physiol. 1996 Jan; 80(1):298-306.
    View in: PubMed
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  99. Kurrek MM, Zapol WM, Holzmann A, Filippov G, Winkler M, Bloch KD. In vivo lipopolysaccharide pretreatment inhibits cGMP release from the isolated-perfused rat lung. Am J Physiol. 1995 Nov; 269(5 Pt 1):L618-24.
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  102. Kurrek MM, Castillo L, Bloch KD, Tannenbaum SR, Zapol WM. Inhaled nitric oxide does not alter endotoxin-induced nitric oxide synthase activity during rat lung perfusion. J Appl Physiol. 1995 Oct; 79(4):1088-92.
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  103. Ichinose F, Huang PL, Zapol WM. Effects of targeted neuronal nitric oxide synthase gene disruption and nitroG-L-arginine methylester on the threshold for isoflurane anesthesia. Anesthesiology. 1995 Jul; 83(1):101-8.
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  104. Kawai N, Bloch DB, Filippov G, Rabkina D, Suen HC, Losty PD, Janssens SP, Zapol WM, de la Monte S, Bloch KD. Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Am J Physiol. 1995 Apr; 268(4 Pt 1):L589-95.
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  105. Ichinose F, Adrie C, Hurford WE, Zapol WM. Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs. J Appl Physiol. 1995 Apr; 78(4):1288-95.
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  106. Staples JF, Zapol WM, Bloch KD, Kawai N, Val VM, Hochachka PW. Nitric oxide responses of air-breathing and water-breathing fish. Am J Physiol. 1995 Mar; 268(3 Pt 2):R816-9.
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  107. Roberts JD, Roberts CT, Jones RC, Zapol WM, Bloch KD. Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res. 1995 Feb; 76(2):215-22.
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  108. Kurrek MM, Winkler M, Robinson DR, Zapol WM. Platelet factor 4 injection produces acute pulmonary hypertension in the awake lamb. Anesthesiology. 1995 Jan; 82(1):183-7; discussion 31A.
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  109. Frostell CG, Zapol WM. Inhaled nitric oxide, clinical rationale and applications. Adv Pharmacol. 1995; 34:439-56.
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  110. Semigran MJ, Cockrill BA, Kacmarek R, Thompson BT, Zapol WM, Dec GW, Fifer MA. Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol. 1994 Oct; 24(4):982-8.
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  111. Husain M, Adrie C, Ichinose F, Kavosi M, Zapol WM. Exhaled nitric oxide as a marker for organic nitrate tolerance. Circulation. 1994 Jun; 89(6):2498-502.
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  112. Zapol WM, Rimar S, Gillis N, Marletta M, Bosken CH. Nitric oxide and the lung. Am J Respir Crit Care Med. 1994 May; 149(5):1375-80.
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  113. Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD, Zapol WM. Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anesthesiology. 1994 Apr; 80(4):761-70.
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  114. Fratacci MD, Kimball WR, Wain JC, Greene EM, Zapol WM. Effects of digoxin on regional diaphragm function after thoracotomy in awake sheep. Respir Physiol. 1994 Mar; 95(3):259-71.
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  115. Zapol WM, Falke KJ, Hurford WE, Roberts JD. Inhaling nitric oxide: a selective pulmonary vasodilator and bronchodilator. Chest. 1994 Mar; 105(3 Suppl):87S-91S.
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  116. Zapol WM, Hurford WE. Inhaled nitric oxide in adult respiratory distress syndrome and other lung diseases. Adv Pharmacol. 1994; 31:513-30.
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  117. Rovira I, Chen TY, Winkler M, Kawai N, Bloch KD, Zapol WM. Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS. J Appl Physiol. 1994 Jan; 76(1):345-55.
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  118. Zapol WM, Hurford WE. Inhaled nitric oxide in the adult respiratory distress syndrome and other lung diseases. New Horiz. 1993 Nov; 1(4):638-50.
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  119. Shimouchi A, Janssens SP, Bloch DB, Zapol WM, Bloch KD. cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts. Am J Physiol. 1993 Nov; 265(5 Pt 1):L456-61.
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  120. Liggins GC, France JT, Schneider RC, Knox BS, Zapol WM. Concentrations, metabolic clearance rates, production rates and plasma binding of cortisol in Antarctic phocid seals. Acta Endocrinol (Copenh). 1993 Oct; 129(4):356-9.
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  121. Polaner DM, Kimball WR, Fratacci MD, Wain JC, Zapol WM. Thoracic epidural anesthesia increases diaphragmatic shortening after thoracotomy in the awake lamb. Anesthesiology. 1993 Oct; 79(4):808-16.
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  122. Fratacci MD, Kimball WR, Wain JC, Kacmarek RM, Polaner DM, Zapol WM. Diaphragmatic shortening after thoracic surgery in humans. Effects of mechanical ventilation and thoracic epidural anesthesia. Anesthesiology. 1993 Oct; 79(4):654-65.
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  123. Montalescot G, Fischman AJ, Strauss HW, Wilkinson RA, Ahmad M, Fitzgibbon C, Robinson DW, Zapol WM. Imaging the ovine heparin-protamine interaction with 111In-protamine. J Appl Physiol. 1993 Aug; 75(2):963-71.
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  124. Chen TY, Zapol WM, Greene E, Robinson DR, Rubin RH. Protective effects of E5, an antiendotoxin monoclonal antibody, in the ovine pulmonary circulation. J Appl Physiol. 1993 Jul; 75(1):233-9.
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  125. Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology. 1993 Mar; 78(3):427-35.
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  126. Rossaint R, Falke KJ, López F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993 Feb 11; 328(6):399-405.
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  127. Roberts JD, Chen TY, Kawai N, Wain J, Dupuy P, Shimouchi A, Bloch K, Polaner D, Zapol WM. Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb. Circ Res. 1993 Feb; 72(2):246-54.
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  128. Torres A, Kacmarek RM, Kimball WR, Qvist J, Stanek K, Whyte R, Zapol WM. Regional diaphragmatic length and EMG activity during inspiratory pressure support and CPAP in awake sheep. J Appl Physiol. 1993 Feb; 74(2):695-703.
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  129. Roberts JD, Lang P, Bigatello LM, Vlahakes GJ, Zapol WM. Inhaled nitric oxide in congenital heart disease. Circulation. 1993 Feb; 87(2):447-53.
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  130. Zapol WM. Iatrogenic complications in the intensive care unit. Crit Care Med. 1993 Jan; 21(1):8-9.
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  131. Zapol WM. Minidose inhaled nitric oxide: less is better. Intensive Care Med. 1993; 19(8):433-4.
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  132. Chen TY, Warren HS, Greene E, Black KM, Frostell CG, Robinson DR, Zapol WM. Protective effects of anti-O polysaccharide and anti-lipid A monoclonal antibodies on pulmonary hemodynamics. J Appl Physiol. 1993 Jan; 74(1):423-7.
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  133. Radermacher P, Falke KJ, Park YS, Ahn DW, Hong SK, Qvist J, Zapol WM. Nitrogen tensions in brachial vein blood of Korean ama divers. J Appl Physiol. 1992 Dec; 73(6):2592-5.
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  134. Montalescot G, Huerta JM, Braquet P, Zapol WM. Role of platelet-activating factor in the ovine heparin-protamine reaction. J Appl Physiol. 1992 Dec; 73(6):2604-7.
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  135. Zapol WM. Volotrauma and the intravenous oxygenator in patients with adult respiratory distress syndrome. Anesthesiology. 1992 Nov; 77(5):847-9.
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  136. Roberts JD, Polaner DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 1992 Oct 3; 340(8823):818-9.
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  137. Dupuy PM, Shore SA, Drazen JM, Frostell C, Hill WA, Zapol WM. Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest. 1992 Aug; 90(2):421-8.
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  138. Polaner DM, Kimball WR, Fratacci MD, Wain JC, Torres A, Kacmarek RM, Zapol WM. Effects of aminophylline on regional diaphragmatic shortening after thoracotomy in the awake lamb. Anesthesiology. 1992 Jul; 77(1):93-100.
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  139. Warren HS, Glennon ML, Wainwright N, Amato SF, Black KM, Kirsch SJ, Riveau GR, Whyte RI, Zapol WM, Novitsky TJ. Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor. Infect Immun. 1992 Jun; 60(6):2506-13.
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  140. Homma S, Jones R, Qvist J, Zapol WM, Reid L. Pulmonary vascular lesions in the adult respiratory distress syndrome caused by inhalation of zinc chloride smoke: a morphometric study. Hum Pathol. 1992 Jan; 23(1):45-50.
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  141. Fratacci MD, Frostell CG, Chen TY, Wain JC, Robinson DR, Zapol WM. Inhaled nitric oxide. A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep. Anesthesiology. 1991 Dec; 75(6):990-9.
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  142. Morel DR, Skoskiewicz M, Robinson DR, Bloch KJ, Hoaglin DC, Zapol WM. Leukotrienes, thromboxane A2, and prostaglandins during systemic anaphylaxis in sheep. Am J Physiol. 1991 Sep; 261(3 Pt 2):H782-92.
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  143. Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation. 1991 Jun; 83(6):2038-47.
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  144. Hurford WE, Lynch KE, Strauss HW, Lowenstein E, Zapol WM. Myocardial perfusion as assessed by thallium-201 scintigraphy during the discontinuation of mechanical ventilation in ventilator-dependent patients. Anesthesiology. 1991 Jun; 74(6):1007-16.
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  145. Zapol WM. A nordic ECMO saga or whither ECMO? Intensive Care Med. 1991; 17(2):69-70.
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  146. Montalescot G, Lowenstein E, Ogletree ML, Greene EM, Robinson DR, Hartl K, Zapol WM. Thromboxane receptor blockade prevents pulmonary hypertension induced by heparin-protamine reactions in awake sheep. Circulation. 1990 Nov; 82(5):1765-77.
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  147. Montalescot G, Zapol WM, Carvalho A, Robinson DR, Torres A, Lowenstein E. Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep. Circulation. 1990 Nov; 82(5):1754-64.
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  148. Lowenstein E, Zapol WM. Protamine reactions, explosive mediator release, and pulmonary vasoconstriction. Anesthesiology. 1990 Sep; 73(3):373-5.
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  149. Hurford WE, Hong SK, Park YS, Ahn DW, Shiraki K, Mohri M, Zapol WM. Splenic contraction during breath-hold diving in the Korean ama. J Appl Physiol. 1990 Sep; 69(3):932-6.
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  150. Zapol WM. Hemodynamics and therapy in ARDS. Minerva Anestesiol. 1990 Jul-Aug; 56(7-8):471-3.
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  151. Bernstein SC, Skoskiewicz MJ, Jones R, Zapol WM, Russell PS. Recombinant gene expression in pulmonary vascular endothelial cells: polarized secretion in vivo. FASEB J. 1990 Jun; 4(9):2665-70.
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  152. Bertozzi P, Astedt B, Zenzius L, Lynch K, LeMaire F, Zapol W, Chapman HA. Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N Engl J Med. 1990 Mar 29; 322(13):890-7.
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  153. Torres A, Kimball WR, Qvist J, Stanek K, Kacmarek RM, Whyte RI, Montalescot G, Zapol WM. Sonomicrometric regional diaphragmatic shortening in awake sheep after thoracic surgery. J Appl Physiol. 1989 Dec; 67(6):2357-68.
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  154. Kreil E, Montalescot G, Greene E, Fitzgibbon C, Robinson D, Chenoweth D, Zapol WM. Nafamstat mesilate attenuates pulmonary hypertension in heparin-protamine reactions. J Appl Physiol. 1989 Oct; 67(4):1463-71.
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  155. Zapol WM, Hill RD, Qvist J, Falke K, Schneider RC, Liggins GC, Hochachka PW. Arterial gas tensions and hemoglobin concentrations of the freely diving Weddell seal. Undersea Biomed Res. 1989 Sep; 16(5):363-73.
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  156. Kreil EA, Greene E, Fitzgibbon C, Robinson DR, Zapol WM. Effects of recombinant human tumor necrosis factor alpha, lymphotoxin, and Escherichia coli lipopolysaccharide on hemodynamics, lung microvascular permeability, and eicosanoid synthesis in anesthetized sheep. Circ Res. 1989 Aug; 65(2):502-14.
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  157. Whyte RI, Warren HS, Greene E, Glennon ML, Robinson DR, Zapol WM. Tolerance to low-dose endotoxin in awake sheep. J Appl Physiol. 1989 Jun; 66(6):2546-52.
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  158. Montalescot G, Kreil E, Lynch K, Greene EM, Torres A, Carvalho A, Fitzgibbon C, Robinson DR, Lowenstein E, Zapol WM. Effect of platelet depletion on lung vasoconstriction in heparin-protamine reactions. J Appl Physiol. 1989 May; 66(5):2344-50.
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  159. Teboul JL, Zapol WM, Brun-Buisson C, Abrouk F, Rauss A, Lemaire F. A comparison of pulmonary artery occlusion pressure and left ventricular end-diastolic pressure during mechanical ventilation with PEEP in patients with severe ARDS. Anesthesiology. 1989 Feb; 70(2):261-6.
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  160. Zapol WM. Understanding images: correlation between computerized tomographic scans of lung structure with impaired function in ARDS. Anesthesiology. 1988 Dec; 69(6):812-4.
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  161. Hochachka PW, Castellini JM, Hill RD, Schneider RC, Bengtson JL, Hill SE, Liggins GC, Zapol WM. Protective metabolic mechanisms during liver ischemia: transferable lessons from long-diving animals. Mol Cell Biochem. 1988 Nov; 84(1):77-85.
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  162. Lemaire F, Teboul JL, Cinotti L, Giotto G, Abrouk F, Steg G, Macquin-Mavier I, Zapol WM. Acute left ventricular dysfunction during unsuccessful weaning from mechanical ventilation. Anesthesiology. 1988 Aug; 69(2):171-9.
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  163. Lichtenstein A, Eckhart WF, Swanson KJ, Vacanti CA, Zapol WM. Unplanned intraoperative and postoperative hemodilution: oxygen transport and consumption during severe anemia. Anesthesiology. 1988 Jul; 69(1):119-22.
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  164. Morel DR, Lowenstein E, Nguyenduy T, Robinson DR, Repine JE, Chenoweth DE, Zapol WM. Acute pulmonary vasoconstriction and thromboxane release during protamine reversal of heparin anticoagulation in awake sheep. Evidence for the role of reactive oxygen metabolites following nonimmunological complement activation. Circ Res. 1988 May; 62(5):905-15.
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  165. Hurford WE, Zapol WM. The right ventricle and critical illness: a review of anatomy, physiology, and clinical evaluation of its function. Intensive Care Med. 1988; 14 Suppl 2:448-57.
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  166. Zapol WM. A letter from Boston. Intensive Care Med. 1988; 14(2):178-9.
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  167. Hjortsø E, Qvist J, Bud MI, Thomsen JL, Andersen JB, Wiberg-Jørgensen F, Jensen NK, Jones R, Reid LM, Zapol WM. ARDS after accidental inhalation of zinc chloride smoke. Intensive Care Med. 1988; 14(1):17-24.
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  168. Hill RD, Schneider RC, Liggins GC, Schuette AH, Elliott RL, Guppy M, Hochachka PW, Qvist J, Falke KJ, Zapol WM. Heart rate and body temperature during free diving of Weddell seals. Am J Physiol. 1987 Aug; 253(2 Pt 2):R344-51.
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  169. Zapol WM, Jones R. Vascular components of ARDS. Clinical pulmonary hemodynamics and morphology. Am Rev Respir Dis. 1987 Aug; 136(2):471-4.
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  170. Carvalho AC, Quinn DA, DeMarinis SM, Beitz JG, Zapol WM. Platelet function in acute respiratory failure. Am J Hematol. 1987 Aug; 25(4):377-88.
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  171. Whalen RL, Hurford WE, Skoskiewicz M, Wonders TR, Zapol WM. A new right ventricular assist device. The extracorporeal pulsatile assist device (EPAD). ASAIO Trans. 1987 Jul-Sep; 33(3):222-6.
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  172. Zapol WM. Diving adaptations of the Weddell seal. Sci Am. 1987 Jun; 256(6):100-5.
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  173. Morel DR, Huttemeier PC, Skoskiewicz MJ, Nguyenduy T, Melvin C, Robinson DR, Zapol WM. Dose-dependent effects of a pyridoquinazoline thromboxane synthetase inhibitor on arachidonic acid metabolites and hemodynamics during E. coli endotoxemia in anesthetized sheep. Prostaglandins. 1987 Jun; 33(6):879-902.
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  174. Collee GG, Lynch KE, Hill RD, Zapol WM. Bedside measurement of pulmonary capillary pressure in patients with acute respiratory failure. Anesthesiology. 1987 May; 66(5):614-20.
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  175. Morel DR, Zapol WM, Thomas SJ, Kitain EM, Robinson DR, Moss J, Chenoweth DE, Lowenstein E. C5a and thromboxane generation associated with pulmonary vaso- and broncho-constriction during protamine reversal of heparin. Anesthesiology. 1987 May; 66(5):597-604.
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  176. Greene R, Lind S, Jantsch H, Wilson R, Lynch K, Jones R, Carvalho A, Reid L, Waltman AC, Zapol W. Pulmonary vascular obstruction in severe ARDS: angiographic alterations after i.v. fibrinolytic therapy. AJR Am J Roentgenol. 1987 Mar; 148(3):501-8.
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  177. Quinn DA, Carvalho AC, Geller E, Khaw BA, Barlaikovach M, Zielonka J, Greene R, Strauss HW, Zapol WM. 99mTc-fibrinogen scanning in adult respiratory distress syndrome. Am Rev Respir Dis. 1987 Jan; 135(1):100-6.
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  178. Michelassi F, Schuette A, Landa L, Zapol WM, Grillo HC. Pulmonary and systemic contribution to canine tracheobronchial blood flow. Ital J Surg Sci. 1987; 17(2):105-12.
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  179. Qvist J, Hill RD, Schneider RC, Falke KJ, Liggins GC, Guppy M, Elliot RL, Hochachka PW, Zapol WM. Hemoglobin concentrations and blood gas tensions of free-diving Weddell seals. J Appl Physiol. 1986 Oct; 61(4):1560-9.
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  180. Robinson DR, Skoskiewicz M, Bloch KJ, Castorena G, Hayes E, Lowenstein E, Melvin C, Michelassi F, Zapol WM. Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep. J Exp Med. 1986 Jun 1; 163(6):1509-17.
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  181. Jones R, Kirton OC, Zapol WM, Reid L. Rat pulmonary artery wall injury by chronic intermittent infusions of Escherichia coli endotoxin. Obliterative vasculitis and vascular occlusion. Lab Invest. 1986 Mar; 54(3):282-94.
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  182. Guppy M, Hill RD, Schneider RC, Qvist J, Liggins GC, Zapol WM, Hochachka PW. Microcomputer-assisted metabolic studies of voluntary diving of Weddell seals. Am J Physiol. 1986 Feb; 250(2 Pt 2):R175-87.
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  183. Jones R, Zapol WM, Reid L. Oxygen toxicity and restructuring of pulmonary arteries--a morphometric study. The response to 4 weeks' exposure to hyperoxia and return to breathing air. Am J Pathol. 1985 Nov; 121(2):212-23.
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  184. Falke KJ, Hill RD, Qvist J, Schneider RC, Guppy M, Liggins GC, Hochachka PW, Elliott RE, Zapol WM. Seal lungs collapse during free diving: evidence from arterial nitrogen tensions. Science. 1985 Aug 9; 229(4713):556-8.
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  185. Jones R, Zapol WM, Reid L. Pulmonary artery remodeling and pulmonary hypertension after exposure to hyperoxia for 7 days. A morphometric and hemodynamic study. Am J Pathol. 1984 Nov; 117(2):273-85.
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  186. Kirton OC, Jones R, Zapol WM, Reid L. The development of a model of subacute lung injury after intra-abdominal infection. Surgery. 1984 Aug; 96(2):384-94.
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  187. Geller E, Khaw BA, Strauss HW, Carvalho AC, Rajagopalan B, Jones R, Zapol WM. Technetium-fibrinogen lung scanning in canine lung contusion. J Trauma. 1984 Jul; 24(7):611-8.
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  188. Zapol WM, Wilson R, Hales C, Fish D, Castorena G, Hilgenberg A, Quinn D, Kradin R. Venovenous bypass with a membrane lung to support bilateral lung lavage. JAMA. 1984 Jun 22-29; 251(24):3269-71.
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  189. Schuette AH, Hüttemeier PC, Hill RD, Watkins WD, Wonders TR, Kong D, Zapol WM. Regional blood flow and pulmonary thromboxane release after sublethal endotoxin infusion in sheep. Surgery. 1984 Apr; 95(4):444-53.
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  190. Michelassi F, Castorena G, Hill RD, Lowenstein E, Watkins WD, Petkau AJ, Zapol WM. Effects of leukotrienes B4 and C4 on coronary circulation and myocardial contractility. Surgery. 1983 Aug; 94(2):267-75.
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  191. Tomashefski JF, Davies P, Boggis C, Greene R, Zapol WM, Reid LM. The pulmonary vascular lesions of the adult respiratory distress syndrome. Am J Pathol. 1983 Jul; 112(1):112-26.
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  192. Jones R, Zapol WM, Reid L. Pulmonary arterial wall injury and remodelling by hyperoxia. Chest. 1983 May; 83(5 Suppl):40S-42S.
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  193. Hüttemeier PC, Berry D, Bloch KJ, Watkins WD, Zapol WM. Pulmonary vasoconstriction and profound leukopenia in two sheep experimental models. Effects of complement depletion. Chest. 1983 May; 83(5 Suppl):24S-25S.
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  194. Erdmann AJ, Hüttemeier PC, Landolt C, Zapol WM. Pure oxygen breathing increases sheep lung microvascular permeability. Anesthesiology. 1983 Feb; 58(2):153-8.
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  195. Wonders T, Huttemeier P, Berry D, Schuette A, Kong D, Watkins WD, Zapol WM. Complement depletion prevents pulmonary hypertension and leukopenia in sheep extracorporeal membrane oxygenation. Trans Am Soc Artif Intern Organs. 1983; 29:210-4.
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  196. Michelassi F, Landa L, Hill RD, Huttemeier P, Lowenstein E, Zapol WM, Watkins WD. Leukotriene D4: a potent sheep coronary vasoconstrictor not blocked by ibuprofen. Adv Prostaglandin Thromboxane Leukot Res. 1983; 11:397-9.
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  197. Snow RL, Davies P, Pontoppidan H, Zapol WM, Reid L. Pulmonary vascular remodeling in adult respiratory distress syndrome. Am Rev Respir Dis. 1982 Nov; 126(5):887-92.
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  198. Carvalho AC, Bellman SM, Saullo VJ, Quinn D, Zapol WM. Altered factor VIII in acute respiratory failure. N Engl J Med. 1982 Oct 28; 307(18):1113-9.
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  199. Peterson MB, Huttemeier PC, Zapol WM, Martin EG, Watkins WD. Thromboxane mediates acute pulmonary hypertension in sheep extracorporeal perfusion. Am J Physiol. 1982 Sep; 243(3):H471-9.
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  200. Michelassi F, Landa L, Hill RD, Lowenstein E, Watkins WD, Petkau AJ, Zapol WM. Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. Science. 1982 Aug 27; 217(4562):841-3.
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  201. Hüttemeier PC, Watkins WD, Peterson MB, Zapol WM. Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep. Circ Res. 1982 May; 50(5):688-94.
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  202. Schuette AH, Hüttemeier PC, Watkins WD, Zapol WM. Effect of lung thromboxane generation on regional blood flow during sheep bypass. Am J Physiol. 1982 Mar; 242(3):H462-9.
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  203. Murphy BJ, Hochachka PW, Zapol WM, Liggins GC. Free amino acids in the blood of fetal and maternal Weddell seals. Am J Physiol. 1982 Jan; 242(1):R85-8.
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  204. Greene R, Zapol WM, Snider MT, Reid L, Snow R, O'Connell RS, Novelline RA. Early bedside detection of pulmonary vascular occlusion during acute respiratory failure. Am Rev Respir Dis. 1981 Nov; 124(5):593-601.
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  205. Qvist J, Weber RE, Zapol WM. Oxygen equilibrium properties of blood and hemoglobin of fetal and adult Weddell seals. J Appl Physiol. 1981 May; 50(5):999-1005.
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  206. Wonders TR, Southmayd JR, Schuette AH, Huttemeier PC, Kong D, Watkins WD, Carvalho A, Zapol WM. Reduced plasma thromboxane elevation during partial cardiopulmonary bypass in thrombocytopenic sheep. Trans Am Soc Artif Intern Organs. 1981; 27:276-9.
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  207. Liggins GC, Qvist J, Hochachka PW, Murphy BJ, Creasy RK, Schneider RC, Snider MT, Zapol WM. Fetal cardiovascular and metabolic responses to simulated diving in the Weddell seal. J Appl Physiol. 1980 Sep; 49(3):424-30.
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  208. Schneider RC, Zapol WM, Carvalho AC. Platelet consumption and sequestration in severe acute respiratory failure. Am Rev Respir Dis. 1980 Sep; 122(3):445-51.
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  209. Zapol WM, Snider MT. Membrane lungs for acute respiratory failure: current status. Am Rev Respir Dis. 1980 Jun; 121(6):907-9.
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  210. Murphy B, Zapol WM, Hochachka PW. Metabolic activities of heart, lung, and brain during diving and recovery in the Weddell seal. J Appl Physiol. 1980 Apr; 48(4):596-605.
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  211. Zapol WM, Peterson MB, Wonders TR, Kong D, Watkins WD. Plasma thromboxane and prostacyclin metabolites in sheep partial cardiopulmonary bypass. Trans Am Soc Artif Intern Organs. 1980; 26:556-60.
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  212. Zapol WM, Snider MT, Hill JD, Fallat RJ, Bartlett RH, Edmunds LH, Morris AH, Peirce EC, Thomas AN, Proctor HJ, Drinker PA, Pratt PC, Bagniewski A, Miller RG. Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study. JAMA. 1979 Nov 16; 242(20):2193-6.
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  213. Zapol WM, Liggins GC, Schneider RC, Qvist J, Snider MT, Creasy RK, Hochachka PW. Regional blood flow during simulated diving in the conscious Weddell seal. J Appl Physiol. 1979 Nov; 47(5):968-73.
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  214. Zapol WM. What future for ECMO? Int J Artif Organs. 1979 Sep; 2(5):231-2.
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  215. Liggins GC, France JT, Knox BS, Zapol WM. High corticosteroid levels in plasma of adult and foetal Weddell seals (Leptonychotes weddelli). Acta Endocrinol (Copenh). 1979 Apr; 90(4):718-26.
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  216. Zapol WM, Trelstad RL, Coffey JW, Tsai I, Salvador RA. Pulmonary fibrosis in severe acute respiratory failure. Am Rev Respir Dis. 1979 Apr; 119(4):547-54.
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  217. Hochachka PW, Murphy B, Liggins CG, Zapol W, Crensy R, Snider M, Schneider R, Quist J. Unusual maternal--fetal blood glucose concentrations in Weddell seal. Nature. 1979 Feb 1; 277(5695):388-9.
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  218. Delaney AG, Zapol WM, Erdmann AJ. Lung transvascular fluid dynamics with extracorporeal membrane oxygenation in unanesthetized lambs. J Thorac Cardiovasc Surg. 1979 Feb; 77(2):252-8.
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  219. Cooper JD, Richardson P, Kolobow T, Zapol W. Panel conference: prolonged respiratory support. Trans Am Soc Artif Intern Organs. 1979; 25:521-2.
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  220. Zapol WM. Membrane lung therapy of acute respiratory failure. Intensive Care Med. 1978 Nov; 4(4):171.
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  221. Delaney AG, Zapol WM, Erdmann AJ. Pulmonary transvascular fluid dynamics with extracorporeal membrane oxygenation in awake lambs. Surg Forum. 1978; 29:194-6.
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  222. Hochachka PW, Liggins GC, Qvist J, Schneider R, Snider MY, Wonders TR, Zapol WM. Pulmonary metabolism during diving: conditioning blood for the brain. Science. 1977 Nov 25; 198(4319):831-4.
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  223. Qvist J, Weber RE, DeVries AL, Zapol WM. pH and haemoglobin oxygen affinity in blood from the Antarctic cod Dissostichus mawsoni. J Exp Biol. 1977 Apr; 67:77-88.
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  224. Zapol WM, Snider MT, Schneider RC. Extracorporeal membrane oxygenation for acute respiratory failure. Anesthesiology. 1977 Apr; 46(4):272-85.
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  225. Zapol WM, Snider MT. Pulmonary hypertension in severe acute respiratory failure. N Engl J Med. 1977 Mar 3; 296(9):476-80.
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  226. Zapol WM, Kobayashi K, Snider MT, Greene R, Laver MB. Vascular obstruction causes pulmonary hypertension in severe acute respiratory failure. Chest. 1977 Feb; 71(2 suppl):306-7.
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  227. Boucher R, Zapol WM, Snider M. Week long partial pulmonary bypass with an artificial lung pumped by the right ventricle. Trans Am Soc Artif Intern Organs. 1977; 23:448-55.
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  228. Liland AE, Zapol WM, Qvist J, Nash G, Skoskiewicz M, Pontoppidan H, Lowenstein E, Laver MB. Positive airway pressure in lambs spontaneously breathing air and oxygen. J Surg Res. 1976 Feb; 20(2):85-92.
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  229. Bloom SR, Snider MT, Petersen R, Wonders TR, Zapol WM. Platelet lifespan and gas exchange during perfusion with spiral coil membrane lungs coated with ethylcellulose perfluorobutyrate. Trans Am Soc Artif Intern Organs. 1976; 22:119-27.
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  230. Zapol WM, Schneider R, Snider M, Rie M. Partial bypass with membrane lungs for acute respiratory failure. Int Anesthesiol Clin. 1976; 14(1):119-33.
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  231. McEnany MT, Zapol WM, Seebacher J, Skoskiewicz M, Schneider RC, Erdmann AJ, Snider MT, Kanarek DJ, Peck AG. Cannulation of the proximal aorta during long-term membrane lung perfusion. J Thorac Cardiovasc Surg. 1975 Oct; 70(4):631-43.
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  232. Cooper JD, Duffin J, Zapol WM. Cannulation of ascending aorta for long-term membrane oxygenator support. J Thorac Cardiovasc Surg. 1975 Jun; 69(6):905-8.
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  233. Zapol WM. Membrane lung perfusion for acute respiratory failure. Surg Clin North Am. 1975 Jun; 55(3):603-12.
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  234. Zapol WM, Qvist J, Pontoppidan H, Liland A, McEnany T, Laver MB. Extracorporeal perfusion for acute respiratory failure: recent experience with the spiral coil membrane lung. J Thorac Cardiovasc Surg. 1975 Mar; 69(3):439-49.
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  235. Ketteringham J, Zapol W, Birkett J, Nelsen L, Massucco A, Raith C. A high permeability, nonporpus, blood compatible membrane for membrane lungs: in vivo and in vitro performance. Trans Am Soc Artif Intern Organs. 1975; 21:224-33.
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  236. Zapol WM, Bloom S, Carvalho A, Wonders T, Skoskiewicz M, Schneider R, Snider M. Improved platelet economy using filler free silicone rubber in long term membrane lung perfusion. Trans Am Soc Artif Intern Organs. 1975; 21:587-92.
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  237. Kanarek D, Zapol W, Ahluwalia B, Qvist J, Hales C, Liland A. Radionuclide imaging of the circulatory distribution of membrane lung perfusion. Trans Am Soc Artif Intern Organs. 1974; 20A:262-8.
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  238. Bloom S, Zapol W, Wonders T, Berger S, Salzman E. Platelet destruction during 24 hour membrane lung perfusion. Trans Am Soc Artif Intern Organs. 1974; 20A:299-305.
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  239. McCullough NJ, Falke K, Lowenstein E, Buckley MJ, Schmidt V, Zapol WM. Respiratory gas exchange with spiral coil membrane lungs: total cardiopulmonary bypass in adult sheep and clinical experience with long-term perfusion in adult patients. Mt Sinai J Med. 1973 Mar-Apr; 40(2):207-21.
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  240. Ketteringham JM, Zapol WM, Gray DN, Stevenson KK, Massucco AA, Nelsen LL, Cullen DP. Polyalkylsulfone: a new polymer for membrane oxygenators. Trans Am Soc Artif Intern Organs. 1973; 19:61-5.
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  241. Zapol WM, Kitz RJ. Buying time with artificial lungs. N Engl J Med. 1972 Mar 23; 286(12):657-8.
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  242. Zapol W, Pontoppidan H, McCullough N, Schmidt V, Bland J, Kitz R. Clinical membrane lung support for acute respiratory insufficiency. Trans Am Soc Artif Intern Organs. 1972; 18(0):553-60, 562.
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  243. Schmidt V, Zapol W, Prensky W, Wonders T, Wodinsky I, Kitz R. Continuous cancer chemotherapy: nitrosourea diffusion through implanted silicone rubber capsules. Trans Am Soc Artif Intern Organs. 1972; 18(0):45-53.
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  244. Doppman JL, Zapol W, Pierce J. Transcatheter embolization with a silicone rubber preparation. Experimental observations. Invest Radiol. 1971 Sep-Oct; 6(5):304-9.
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  245. Zapol WM, Kolobow T, Doppman J, Pierce JE. Response of ductus arteriosus and pulmonary blood flow to blood oxygen tension in immersed lamb fetuses perfused through an artificial placenta. J Thorac Cardiovasc Surg. 1971 Jun; 61(6):891-903.
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  246. Kolobow T, Spragg RG, Pierce JE, Zapol WM. Extended term (to 16 days) partial extracorporeal blood gas exchange with the spiral membrane lung in unanesthetized lambs. Trans Am Soc Artif Intern Organs. 1971; 17:350-4.
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  247. Kolobow T, Zapol WM, Sigman RL, Pierce J. Partial cardiopulmonary bypass lasting up to seven days in alert lambs with membrane lung blood oxygenation. J Thorac Cardiovasc Surg. 1970 Dec; 60(6):781-8.
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  248. Kolobow T, Zapol W. A new thin-walled nonkinking catheter for peripheral vascular cannulation. Surgery. 1970 Oct; 68(4):625-9.
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  249. Doppman JL, Zapol W, Kolobow T, Pierce J. Angiocardiography of fetal lambs on artificial placenta. Invest Radiol. 1970 May-Jun; 5(3):181-6.
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  250. Zapol WM, Kolobow T, Pierce JEVUREK GG, Bowman RL. Artificial placenta: two days of total extrauterine support of the isolated premature lamb fetus. Science. 1969 Oct 31; 166(3905):617-8.
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  251. Kolobow T, Zapol W, Pierce J. High survival and minimal blood damage in lambs exposed to long term (1 week) veno-venous pumping with a polyurethane chamber roller pump with and without a membrane blood oxygenator. Trans Am Soc Artif Intern Organs. 1969; 15:172-7.
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  252. Kolobow T, Zapol W, Pierce JE, Keeley AF, Replogle RL, Haller A. Partial extracorporeal gas exchange in alert newborn lambs with a membrane artificial lung perfused via an A-V shunt for periods up to 96 hours. Trans Am Soc Artif Intern Organs. 1968; 14:328-34.
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