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Last Name
Institution

Charles Albert Hales, M.D.

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Pulmonary, Bul 148
55 Fruit St
Boston MA 02114
Phone617/726-8854
Fax617/726-6878

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ochoa C, Garg H, Hales C, Quinn D. Low molecular weight hyaluronan, via AP-1 and NF-?B signalling, induces IL-8 in transformed bronchial epithelial cells. Swiss Med Wkly. 2011; 141:w13255.
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  2. Londy FJ, Lowe S, Stein PD, Weg JG, Eisner RL, Leeper KV, Woodard PK, Sostman HD, Jablonski KA, Fowler SE, Hales CA, Hull RD, Gottschalk A, Naidich DP, Chenevert TL. Comparison of 1.5 and 3.0 T for contrast-enhanced pulmonary magnetic resonance angiography. Clin Appl Thromb Hemost. 2012 Mar-Apr; 18(2):134-9.
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  3. Yu L, Hales CA. Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice. BMC Cancer. 2011; 11:331.
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  4. Garg HG, Mrabat H, Yu L, Hales CA, Li B, Moore CN, Zhang F, Linhardt RJ. Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells. Glycoconj J. 2011 Aug; 28(6):419-26.
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  5. Yu L, Hales CA. Hypoxia does neither stimulate pulmonary artery endothelial cell proliferation in mice and rats with pulmonary hypertension and vascular remodeling nor in human pulmonary artery endothelial cells. J Vasc Res. 2011; 48(6):465-75.
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  6. Yu L, Hales CA. Silencing of sodium-hydrogen exchanger 1 attenuates the proliferation, hypertrophy, and migration of pulmonary artery smooth muscle cells via E2F1. Am J Respir Cell Mol Biol. 2011 Nov; 45(5):923-30.
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  7. Ochoa CD, Fouty BW, Hales CA. Thrombospondin-1, endothelium and systemic vascular tone. Future Cardiol. 2011 Mar; 7(2):169-72.
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  8. Sostman HD, Jablonski KA, Woodard PK, Stein PD, Naidich DP, Chenevert TL, Weg JG, Hales CA, Hull RD, Goodman LR, Tapson VF. Factors in the technical quality of gadolinium enhanced magnetic resonance angiography for pulmonary embolism in PIOPED III. Int J Cardiovasc Imaging. 2012 Feb; 28(2):303-12.
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  9. Woodard PK, Chenevert TL, Sostman HD, Jablonski KA, Stein PD, Goodman LR, Londy FJ, Narra V, Hales CA, Hull RD, Tapson VF, Weg JG. Signal quality of single dose gadobenate dimeglumine pulmonary MRA examinations exceeds quality of MRA performed with double dose gadopentetate dimeglumine. Int J Cardiovasc Imaging. 2012 Feb; 28(2):295-301.
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  10. Yu L, Hales CA. Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats. Respir Res. 2011; 12:21.
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  11. Zhao G, Shaik RS, Zhao H, Beagle J, Kuo S, Hales CA. Low molecular weight (LMW) heparin inhibits injury-induced femoral artery remodeling in mouse via upregulating CD44 expression. J Vasc Surg. 2011 May; 53(5):1359-1367.e3.
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  12. Choi WI, Syrkina O, Kwon KY, Quinn DA, Hales CA. JNK activation is responsible for mucus overproduction in smoke inhalation injury. Respir Res. 2010; 11:172.
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  13. Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H. TLR4 through IFN-ß promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J Immunol. 2011 Jan 1; 186(1):556-62.
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  14. Huang PM, Syrkina O, Yu L, Dedaj R, Zhao H, Shiedlin A, Liu YY, Garg H, Quinn DA, Hales CA. High MW hyaluronan inhibits smoke inhalation-induced lung injury and improves survival. Respirology. 2010 Oct; 15(7):1131-9.
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  15. Yu L, Quinn DA, Garg HG, Hales CA. Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27. Am J Respir Cell Mol Biol. 2011 Apr; 44(4):524-30.
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  16. Choi WI, Lee MY, Oh D, Rho BH, Hales CA. Estimated incidence of acute pulmonary embolism in a Korean hospital. Clin Appl Thromb Hemost. 2011 Jun; 17(3):297-301.
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  17. Ochoa CD, Yu L, Al-Ansari E, Hales CA, Quinn DA. Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension. J Cardiothorac Surg. 2010; 5:32.
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  18. Stein PD, Chenevert TL, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, Jablonski KA, Leeper KV, Naidich DP, Sak DJ, Sostman HD, Tapson VF, Weg JG, Woodard PK. Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III). Ann Intern Med. 2010 Apr 6; 152(7):434-43, W142-3.
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  19. Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA. TLR4 is a negative regulator in noninfectious lung inflammation. J Immunol. 2010 May 1; 184(9):5308-14.
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  20. Garg HG, Mrabat H, Yu L, Freeman C, Li B, Zhang F, Linhardt RJ, Hales CA. Effect of carboxyl-reduced heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells. Carbohydr Res. 2010 Jun 16; 345(9):1084-7.
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  21. Yu L, Garg HG, Li B, Linhardt RJ, Hales CA. Antitumor effect of butanoylated heparin with low anticoagulant activity on lung cancer growth in mice and rats. Curr Cancer Drug Targets. 2010 Mar; 10(2):229-41.
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  22. Mrabat H, Garg HG, Hales CA. Growth inhibition of bovine pulmonary artery smooth muscle cells following long-term heparin treatment. J Cell Physiol. 2009 Dec; 221(3):603-8.
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  23. Stein PD, Freeman LM, Sostman HD, Goodman LR, Woodard PK, Naidich DP, Gottschalk A, Bailey DL, Matta F, Yaekoub AY, Hales CA, Hull RD, Leeper KV, Tapson VF, Weg JG. SPECT in acute pulmonary embolism. J Nucl Med. 2009 Dec; 50(12):1999-2007.
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  24. Li Y, Liu B, Zhao H, Sailhamer EA, Fukudome EY, Zhang X, Kheirbek T, Finkelstein RA, Velmahos GC, deMoya M, Hales CA, Alam HB. Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents. Shock. 2009 Nov; 32(5):517-23.
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  25. Mrabat H, Beagle J, Hang Z, Garg HG, Hales CA, Quinn DA. Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model. Lung. 2009 Aug; 187(4):233-9.
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  26. Stein PD, Matta F, Yaekoub AY, Kazerooni EA, Cahill JE, Goodman LR, Sostman HD, Hales CA, Denier JE, Weg JG, Ghumman D, Chan KM, Woodard PK, Kwun Y. CT venous phase venography with 64-detector CT angiography in the diagnosis of acute pulmonary embolism. Clin Appl Thromb Hemost. 2010 Aug; 16(4):422-9.
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  27. Choi WI, Kwon KY, Seo JW, Beagle J, Quinn DA, Hales CA. The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury. BMC Infect Dis. 2009; 9:80.
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  28. Stein PD, Matta F, Yaekoub AY, Goodman LR, Sostman HD, Weg JG, Hales CA, Hull RD, Leeper KV, Beemath A, Saeed IM, Woodard PK. Reconstructed 4-chamber views compared with axial imaging for assessment of right ventricular enlargement on CT pulmonary angiograms. J Thromb Thrombolysis. 2009 Oct; 28(3):342-7.
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  29. Steiner MK, Syrkina OL, Kolliputi N, Mark EJ, Hales CA, Waxman AB. Interleukin-6 overexpression induces pulmonary hypertension. Circ Res. 2009 Jan 30; 104(2):236-44, 28p following 244.
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  30. Stein PD, Gottschalk A, Sostman HD, Chenevert TL, Fowler SE, Goodman LR, Hales CA, Hull RD, Kanal E, Leeper KV, Nadich DP, Sak DJ, Tapson VF, Wakefield TW, Weg JG, Woodard PK. Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III). Semin Nucl Med. 2008 Nov; 38(6):462-70.
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  31. Liu YY, Lee CH, Dedaj R, Zhao H, Mrabat H, Sheidlin A, Syrkina O, Huang PM, Garg HG, Hales CA, Quinn DA. High-molecular-weight hyaluronan--a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats. Crit Care. 2008; 12(4):R102.
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  32. Garg HG, Mrabat H, Yu L, Freeman C, Li B, Zhang F, Linhardt RJ, Hales CA. Significance of the 2-O-sulfo group of L-iduronic acid residues in heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells. Carbohydr Res. 2008 Sep 22; 343(14):2406-10.
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  33. Choi WI, Kwon KY, Kim JM, Quinn DA, Hales CA, Seo JW. Atelectasis induced by thoracotomy causes lung injury during mechanical ventilation in endotoxemic rats. J Korean Med Sci. 2008 Jun; 23(3):406-13.
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  34. Syrkina O, Jafari B, Hales CA, Quinn DA. Oxidant stress mediates inflammation and apoptosis in ventilator-induced lung injury. Respirology. 2008 May; 13(3):333-40.
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  35. Yu L, Quinn DA, Garg HG, Hales CA. Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling. Am J Respir Crit Care Med. 2008 Jun 1; 177(11):1276-84.
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  36. Ochoa CD, Baker H, Hasak S, Matyal R, Salam A, Hales CA, Hancock W, Quinn DA. Cyclic stretch affects pulmonary endothelial cell control of pulmonary smooth muscle cell growth. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):105-12.
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  37. Stein PD, Beemath A, Matta F, Goodman LR, Weg JG, Hales CA, Hull RD, Leeper KV, Sostman HD, Woodard PK. Enlarged right ventricle without shock in acute pulmonary embolism: prognosis. Am J Med. 2008 Jan; 121(1):34-42.
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  38. Al-Ansari E, Du HK, Yu L, Ochoa CD, Garg HG, Quinn DA, Hales CA. Low-molecular-weight heparin inhibits hypoxic pulmonary hypertension and vascular remodeling in guinea pigs. Chest. 2007 Dec; 132(6):1898-905.
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  39. Stein PD, Beemath A, Matta F, Weg JG, Yusen RD, Hales CA, Hull RD, Leeper KV, Sostman HD, Tapson VF, Buckley JD, Gottschalk A, Goodman LR, Wakefied TW, Woodard PK. Clinical characteristics of patients with acute pulmonary embolism: data from PIOPED II. Am J Med. 2007 Oct; 120(10):871-9.
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  40. Meyer GS, Hales CA, Amrein PC, Sharma A, Kradin RL. Case records of the Massachusetts General Hospital. Case 26-2007 - a 61-year-old man with recurrent fevers. N Engl J Med. 2007 Aug 23; 357(8):807-16.
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  41. Stein PD, Beemath A, Quinn DA, Olson RE, Goodman LR, Gottschalk A, Hales CA, Hull RD, Leeper KV, Sostman HD, Weg JG, Woodard PK. Usefulness of multidetector spiral computed tomography according to age and gender for diagnosis of acute pulmonary embolism. Am J Cardiol. 2007 May 1; 99(9):1303-5.
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  42. Syrkina OL, Quinn DA, Jung W, Ouyang B, Hales CA. Inhibition of JNK activation prolongs survival after smoke inhalation from fires. Am J Physiol Lung Cell Mol Physiol. 2007 Apr; 292(4):L984-91.
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  43. Stein PD, Woodard PK, Weg JG, Wakefield TW, Tapson VF, Sostman HD, Sos TA, Quinn DA, Leeper KV, Hull RD, Hales CA, Gottschalk A, Goodman LR, Fowler SE, Buckley JD. Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II Investigators. Radiology. 2007 Jan; 242(1):15-21.
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  44. Stein PD, Woodard PK, Weg JG, Wakefield TW, Tapson VF, Sostman HD, Sos TA, Quinn DA, Leeper KV, Hull RD, Hales CA, Gottschalk A, Goodman LR, Fowler SE, Buckley JD. Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II investigators. Am J Med. 2006 Dec; 119(12):1048-55.
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  45. Efimova O, Volokhov A, Hales CA. Injection of prostaglandin F2alpha into the bronchial artery in sheep increases the pulmonary vascular permeability to protein. Pulm Pharmacol Ther. 2007; 20(2):167-71.
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  46. Garg HG, Hales CA, Yu L, Butler M, Islam T, Xie J, Linhardt RJ. Increase in the growth inhibition of bovine pulmonary artery smooth muscle cells by an O-hexanoyl low-molecular-weight heparin derivative. Carbohydr Res. 2006 Nov 6; 341(15):2607-12.
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  47. Stein PD, Beemath A, Goodman LR, Hales CA, Hull RD, Sostman HD, Weg JG. Outcome studies of pulmonary embolism versus accuracy: they do not equate. Thromb Haemost. 2006 Aug; 96(2):107-8.
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  48. Stein PD, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, Leeper KV, Popovich J, Quinn DA, Sos TA, Sostman HD, Tapson VF, Wakefield TW, Weg JG, Woodard PK. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med. 2006 Jun 1; 354(22):2317-27.
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  49. Yu L, Quinn DA, Garg HG, Hales CA. Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun. 2006 Jul 14; 345(4):1565-72.
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  50. Yu L, Quinn DA, Garg HG, Hales CA. Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice. Circ Res. 2005 Oct 28; 97(9):937-45.
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  51. Jafari B, Ouyang B, Li LF, Hales CA, Quinn DA. Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells. Respirology. 2004 Mar; 9(1):43-53.
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  52. Garg HG, Hales CA. Chemistry and Biology of Hyaluronan. 2004.
  53. Hales CA. . Physiological Function in Hypoxic Pulmonary Vasoconstriction. Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms. Yuan JX-J, ed. 2004; 3-14.
  54. Garg HG, Yu L, Hales CA, Toida T, Islam T, Linhardt RJ. Sulfation patterns in heparin and heparan sulfate: effects on the proliferation of bovine pulmonary artery smooth muscle cells. Biochim Biophys Acta. 2003 Nov 20; 1639(3):225-31.
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  55. Syrkina O, Hales CA. Role of bronchial artery systemic lymph flow after smoke burn injury. Arch Physiol Biochem. 2003 Oct; 111(4):301-3.
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  56. Quinn DA, Moufarrej R, Volokhov A, Syrkina O, Hales CA. Combined smoke inhalation and scald burn in the rat. J Burn Care Rehabil. 2003 Jul-Aug; 24(4):208-16.
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  57. Mascarenhas MM, Day RM, Ochoa CD, Choi WI, Yu L, Ouyang B, Garg HG, Hales CA, Quinn DA. Low molecular weight hyaluronan from stretched lung enhances interleukin-8 expression. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):51-60.
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  58. Choi WI, Quinn DA, Park KM, Moufarrej RK, Jafari B, Syrkina O, Bonventre JV, Hales CA. Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury. Am J Respir Crit Care Med. 2003 Jun 15; 167(12):1627-32.
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  59. Cindhuchao N, Quinn DA, Garg HG, Hales CA. Heparin inhibits SMC growth in the presence of human and fetal bovine serum. Biochem Biophys Res Commun. 2003 Feb 28; 302(1):84-8.
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  60. Longas MO, Garg HG, Trinkle-Pereira JM, Hales CA. Heparin antiproliferative activity on bovine pulmonary artery smooth muscle cells requires both N-acetylation and N-sulfonation. Carbohydr Res. 2003 Jan 31; 338(3):251-6.
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  61. Garg HG, Cindhuchao N, Quinn DA, Hales CA, Thanawiroon C, Capila I, Linhardt RJ. Heparin oligosaccharide sequence and size essential for inhibition of pulmonary artery smooth muscle cell proliferation. Carbohydr Res. 2002 Nov 19; 337(21-23):2359-64.
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  62. Willey-Courand DB, Harris RS, Galletti GG, Hales CA, Fischman A, Venegas JG. Alterations in regional ventilation, perfusion, and shunt after smoke inhalation measured by PET. J Appl Physiol. 2002 Sep; 93(3):1115-22.
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  63. Quinn DA, Moufarrej RK, Volokhov A, Hales CA. Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury. J Appl Physiol. 2002 Aug; 93(2):517-25.
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  64. Garg HG, Hales CA, Linhardt RJ, eds. Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling. Proteoglycans in Lung Disease. 2002; 377-398.
  65. Hales CA, Cockrill BA. Pulmonary Venooclusive Disease. Pulmonary Circulation Peacock AJ, RubinLJ, eds. 2002.
  66. Garg HG, Roughley PJ, Hales CA. Proteoglycans in Lung Disease. 2002.
  67. Hales CA, Du HK, Volokhov A, Mourfarrej R, Quinn DA. Aquaporin channels may modulate ventilator-induced lung injury. Respir Physiol. 2001 Jan; 124(2):159-66.
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  68. Mandel J, Mark EJ, Hales CA. Pulmonary veno-occlusive disease. Am J Respir Crit Care Med. 2000 Nov; 162(5):1964-73.
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  69. Garg HG, Thompson BT, Hales CA. Structural determinants of antiproliferative activity of heparin on pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2000 Nov; 279(5):L779-89.
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  70. Efimova O, Volokhov AB, Iliaifar S, Hales CA. Ligation of the bronchial artery in sheep attenuates early pulmonary changes following exposure to smoke. J Appl Physiol. 2000 Mar; 88(3):888-93.
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  71. Garg HG, Joseph PA, Thompson BT, Hales CA, Toida T, Imanari T, Capila I, Linhardt RJ. Effect of fully sulfated glycosaminoglycans on pulmonary artery smooth muscle cell proliferation. Arch Biochem Biophys. 1999 Nov 15; 371(2):228-33.
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  72. Fukuda T, Kim DK, Chin MR, Hales CA, Bonventre JV. Increased group IV cytosolic phospholipase A2 activity in lungs of sheep after smoke inhalation injury. Am J Physiol. 1999 Sep; 277(3 Pt 1):L533-42.
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  73. Tapson VF, Carroll BA, Davidson BL, Elliott CG, Fedullo PF, Hales CA, Hull RD, Hyers TM, Leeper KV, Morris TA, Moser KM, Raskob GE, Shure D, Sostman HD, Taylor Thompson B. The diagnostic approach to acute venous thromboembolism. Clinical practice guideline. American Thoracic Society. Am J Respir Crit Care Med. 1999 Sep; 160(3):1043-66.
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  74. Quinn D, Tager A, Joseph PM, Bonventre JV, Force T, Hales CA. Stretch-induced mitogen-activated protein kinase activation and interleukin-8 production in type II alveolar cells. Chest. 1999 Jul; 116(1 Suppl):89S-90S.
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  75. Quinn DA, Fogel RB, Smith CD, Laposata M, Taylor Thompson B, Johnson SM, Waltman AC, Hales CA. D-dimers in the diagnosis of pulmonary embolism. Am J Respir Crit Care Med. 1999 May; 159(5 Pt 1):1445-9.
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  76. Cockrill BA, Hales CA. Allergic bronchopulmonary aspergillosis. Annu Rev Med. 1999; 50:303-16.
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  77. Jackson RP, Peterson MD, McManus AC, Hales C. Compensatory spinopelvic balance over the hip axis and better reliability in measuring lordosis to the pelvic radius on standing lateral radiographs of adult volunteers and patients. Spine (Phila Pa 1976). 1998 Aug 15; 23(16):1750-67.
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  78. Quinn D, Du HK, Thompson BT, Garg HG, Hales CA. Effect of dimethyl amiloride on chronic hypoxic pulmonary hypertension in rats. Chest. 1998 Jul; 114(1 Suppl):69S-70S.
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  79. Quinn DA, Du HK, Thompson BT, Hales CA. Amiloride analogs inhibit chronic hypoxic pulmonary hypertension. Am J Respir Crit Care Med. 1998 Apr; 157(4 Pt 1):1263-8.
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  80. Joseph PA, Garg HG, Thompson BT, Liu X, Hales CA. Influence of molecular weight, protein core and charge of native heparin fractions on pulmonary artery smooth muscle cell proliferation. Biochem Biophys Res Commun. 1997 Dec 8; 241(1):18-23.
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  81. Lee SL, Wang WW, Joseph PM, Hales CA, Fanburg BL. Inhibitory effect of heparin on serotonin-induced hyperplasia and hypertrophy of smooth muscle cells. Am J Respir Cell Mol Biol. 1997 Jul; 17(1):78-83.
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  82. Hales CA, Elsasser TH, Ocampo P, Efimova O. TNF-alpha in smoke inhalation lung injury. J Appl Physiol. 1997 May; 82(5):1433-7.
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  83. Herlihy JP, Vermeulen MW, Hales CA. Human alveolar macrophages prevent apoptosis in polymorphonuclear leukocytes. Am J Physiol. 1996 Nov; 271(5 Pt 1):L681-7.
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  84. Garg HG, Joseph PA, Yoshida K, Thompson BT, Hales CA. Antiproliferative role of 3-O-sulfate glucosamine in heparin on cultured pulmonary artery smooth muscle cells. Biochem Biophys Res Commun. 1996 Jul 16; 224(2):468-73.
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  85. Joseph PM, Witten ML, Burke CH, Hales CA. The effects of chronic sidestream cigarette smoke exposure on eicosanoid production by tracheal epithelium. Exp Lung Res. 1996 May-Jun; 22(3):317-35.
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  86. Quinn DA, Dahlberg CG, Bonventre JP, Scheid CR, Honeyman T, Joseph PM, Thompson BT, Hales CA. The role of Na+/H+ exchange and growth factors in pulmonary artery smooth muscle cell proliferation. Am J Respir Cell Mol Biol. 1996 Feb; 14(2):139-45.
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  87. Dahlberg CG, Thompson BT, Joseph PM, Garg HG, Spence CR, Quinn DA, Bonventre JV, Hales CA. Differential effect of three commercial heparins on Na+/H+ exchange and growth of PASMC. Am J Physiol. 1996 Feb; 270(2 Pt 1):L260-5.
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  88. Silverman ES, Thompson BT, Quinn DA, Kinane TB, Bonventre JV, Hales CA. Na+/H+ exchange in pulmonary artery smooth muscle from spontaneously hypertensive and Wistar-Kyoto rats. Am J Physiol. 1995 Nov; 269(5 Pt 1):L673-80.
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  89. Kim DK, Fukuda T, Thompson BT, Cockrill B, Hales C, Bonventre JV. Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome. Am J Physiol. 1995 Jul; 269(1 Pt 1):L109-18.
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  90. Herlihy JP, Vermeulen MW, Joseph PM, Hales CA. Impaired alveolar macrophage function in smoke inhalation injury. J Cell Physiol. 1995 Apr; 163(1):1-8.
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  91. Hales CA, Musto S, Hutchison WG, Mahoney E. BW-755C diminishes smoke-induced pulmonary edema. J Appl Physiol. 1995 Jan; 78(1):64-9.
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  92. Hales CA. Squat like a toad close at the ear of Eve. J Clin Invest. 1994 Sep; 94(3):919-20.
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  93. Janssens SP, Thompson BT, Spence CR, Hales CA. Functional and structural changes with hypoxia in pulmonary circulation of spontaneously hypertensive rats. J Appl Physiol. 1994 Sep; 77(3):1101-7.
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  94. Janssens SP, Musto SW, Hutchison WG, Spence C, Witten M, Jung W, Hales CA. Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury. J Appl Physiol. 1994 Aug; 77(2):888-95.
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  95. Thompson BT, Spence CR, Janssens SP, Joseph PM, Hales CA. Inhibition of hypoxic pulmonary hypertension by heparins of differing in vitro antiproliferative potency. Am J Respir Crit Care Med. 1994 Jun; 149(6):1512-7.
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  96. Spence CR, Thompson BT, Janssens SP, Steigman DM, Hales CA. Effect of aerosol heparin on the development of hypoxic pulmonary hypertension in the guinea pig. Am Rev Respir Dis. 1993 Jul; 148(1):241-4.
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  97. Tsuzaki K, Hales CA, Strieder DJ, Venegas JG. Regional lung mechanics and gas transport in lungs with inhomogeneous compliance. J Appl Physiol. 1993 Jul; 75(1):206-16.
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  98. Venegas JG, Tsuzaki K, Fox BJ, Simon BA, Hales CA. Regional coupling between chest wall and lung expansion during HFV: a positron imaging study. J Appl Physiol. 1993 May; 74(5):2242-52.
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  99. Thompson BT, Steigman DM, Spence CL, Janssens SP, Hales CA. Chronic hypoxic pulmonary hypertension in the guinea pig: effect of three levels of hypoxia. J Appl Physiol. 1993 Feb; 74(2):916-21.
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  100. Janssens SP, Kachoris C, Parker WL, Hales CA, Haupert GT. Hypothalamic Na+,K(+)-ATPase inhibitor constricts pulmonary arteries of spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1993; 22 Suppl 2:S42-6.
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  101. Quinn DA, Thompson BT, Terrin ML, Thrall JH, Athanasoulis CA, McKusick KA, Stein PD, Hales CA. A prospective investigation of pulmonary embolism in women and men. JAMA. 1992 Oct 7; 268(13):1689-96.
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  102. Lesser BA, Leeper KV, Stein PD, Saltzman HA, Chen J, Thompson BT, Hales CA, Popovich J, Greenspan RH, Weg JG. The diagnosis of acute pulmonary embolism in patients with chronic obstructive pulmonary disease. Chest. 1992 Jul; 102(1):17-22.
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  103. Hales CA, Musto SW, Janssens S, Jung W, Quinn DA, Witten M. Smoke aldehyde component influences pulmonary edema. J Appl Physiol. 1992 Feb; 72(2):555-61.
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  104. Stein PD, Athanasoulis C, Alavi A, Greenspan RH, Hales CA, Saltzman HA, Vreim CE, Terrin ML, Weg JG. Complications and validity of pulmonary angiography in acute pulmonary embolism. Circulation. 1992 Feb; 85(2):462-8.
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  105. Hassoun PM, Thompson BT, Hales CA. Partial reversal of hypoxic pulmonary hypertension by heparin. Am Rev Respir Dis. 1992 Jan; 145(1):193-6.
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  106. Janssens SP, Thompson BT, Spence CR, Hales CA. Polycythemia and vascular remodeling in chronic hypoxic pulmonary hypertension in guinea pigs. J Appl Physiol. 1991 Dec; 71(6):2218-23.
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  107. Quinn DA, Honeyman TW, Joseph PM, Thompson BT, Hales CA, Scheid CR. Contribution of Na+/H+ exchange to pH regulation in pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 1991 Dec; 5(6):586-91.
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  108. Venegas JG, Yamada Y, Hales CA. Contributions of diffusion jet flow and cardiac activity to regional ventilation in CFV. J Appl Physiol. 1991 Oct; 71(4):1540-53.
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  109. Stein PD, Terrin ML, Hales CA, Palevsky HI, Saltzman HA, Thompson BT, Weg JG. Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Chest. 1991 Sep; 100(3):598-603.
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  110. Stein PD, Alavi A, Gottschalk A, Hales CA, Saltzman HA, Vreim CE, Weg JG. Usefulness of noninvasive diagnostic tools for diagnosis of acute pulmonary embolism in patients with a normal chest radiograph. Am J Cardiol. 1991 May 15; 67(13):1117-20.
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  111. Venegas JG, Yamada Y, Burnham C, Hales CA. Local gas transport in eucapnic ventilation: effects of gravity and breathing frequency. J Appl Physiol. 1990 Jun; 68(6):2287-95.
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  112. Quinn DA, Robinson D, Jung W, Hales CA. Role of sulfidopeptide leukotrienes in synthetic smoke inhalation injury in sheep. J Appl Physiol. 1990 May; 68(5):1962-9.
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  113. Quinn DA, Robinson D, Hales CA. Intravenous injection of propylene glycol causes pulmonary hypertension in sheep. J Appl Physiol. 1990 Apr; 68(4):1415-20.
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  114. Li JJ, Sanders RL, McAdam KP, Hales CA, Thompson BT, Gelfand JA, Burke JF. Impact of C-reactive protein (CRP) on surfactant function. J Trauma. 1989 Dec; 29(12):1690-7.
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  115. Hales CA, Barkin P, Jung W, Quinn D, Lamborghini D, Burke J. Bronchial artery ligation modifies pulmonary edema after exposure to smoke with acrolein. J Appl Physiol. 1989 Sep; 67(3):1001-6.
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  116. Hassoun PM, Thompson BT, Steigman D, Hales CA. Effect of heparin and warfarin on chronic hypoxic pulmonary hypertension and vascular remodeling in the guinea pig. Am Rev Respir Dis. 1989 Mar; 139(3):763-8.
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  117. Yamada Y, Burnham C, Hales CA, Venegas JG. Regional mapping of gas transport during high-frequency and conventional ventilation. J Appl Physiol. 1989 Mar; 66(3):1209-18.
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  118. Thompson BT, Hassoun PM, Kradin RL, Hales CA. Acute and chronic hypoxic pulmonary hypertension in guinea pigs. J Appl Physiol. 1989 Feb; 66(2):920-8.
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  119. Blumenstock DA, Systrom D, Hales C, Alpern H, Kazemi H. Pulmonary function of haplotype-matched and mismatched allografts in dogs treated with total-body irradiation, autologous marrow transplantation, methotrexate, and donor blood. Transplantation. 1988 Oct; 46(4):496-501.
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  120. Sturgess NC, Kozlowski RZ, Carrington CA, Hales CN, Ashford ML. Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. Br J Pharmacol. 1988 Sep; 95(1):83-94.
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  121. Morris TA, Thompson BT, Quinn DA, McKusick KA, Callahan R, Hales CA. Diffusing capacity is not measurably affected by routine lung perfusion scanning. J Nucl Med. 1988 Jul; 29(7):1268-71.
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  122. Venegas JG, Yamada Y, Custer J, Hales CA. Effects of respiratory variables on regional gas transport during high-frequency ventilation. J Appl Physiol. 1988 May; 64(5):2108-18.
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  123. Hales CA, Barkin PW, Jung W, Trautman E, Lamborghini D, Herrig N, Burke J. Synthetic smoke with acrolein but not HCl produces pulmonary edema. J Appl Physiol. 1988 Mar; 64(3):1121-33.
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  124. Tilles DS, Hales CA. Comparison of 12-hour and 24-hour sustained-release theophylline in outpatient management of asthma. Chest. 1987 Mar; 91(3):370-5.
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  125. Lee CW, Jung W, Lewis RA, Hales CA. LTB4 mediated hypoxemia in guinea pigs: relationship to pulmonary and cardiovascular pathophysiology. Prostaglandins. 1987 Jan; 33(1):3-16.
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  126. Shinozawa Y, Hales C, Jung W, Burke J. Ibuprofen prevents synthetic smoke-induced pulmonary edema. Am Rev Respir Dis. 1986 Dec; 134(6):1145-8.
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  127. Yamada Y, Hales CA, Venegas JG. Inspiratory-to-expiratory time ratio and alveolar ventilation during high-frequency ventilation in dogs. J Appl Physiol. 1986 Nov; 61(5):1903-7.
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  128. Kradin RL, Zhu Y, Hales CA, Bianco C, Colvin RB. Response of pulmonary macrophages to hyperoxic pulmonary injury. Acquisition of surface fibronectin and fibrin/ogen and enhanced expression of a fibronectin receptor. Am J Pathol. 1986 Nov; 125(2):349-57.
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  129. Yamada Y, Venegas JG, Strieder DJ, Hales CA. Effects of mean airway pressure on gas transport during high-frequency ventilation in dogs. J Appl Physiol. 1986 Nov; 61(5):1896-902.
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  130. Thompson BT, Hales CA. Hypoxic pulmonary hypertension: acute and chronic. Heart Lung. 1986 Sep; 15(5):457-65.
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  131. Hales CA, Brandstetter RD, Neely CF, Peterson MB, Kong D, Watkins WD. Methylprednisolone on circulating eicosanoids and vasomotor tone after endotoxin. J Appl Physiol. 1986 Jul; 61(1):185-91.
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  132. Tilles DS, Goldenheim PD, Johnson DC, Mendelson JH, Mello NK, Hales CA. Marijuana smoking as cause of reduction in single-breath carbon monoxide diffusing capacity. Am J Med. 1986 Apr; 80(4):601-6.
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  133. Venegas JG, Hales CA, Strieder DJ. A general dimensionless equation of gas transport by high-frequency ventilation. J Appl Physiol. 1986 Mar; 60(3):1025-30.
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  134. Tilles DS, Goldenheim PD, Ginns LC, Hales CA. Pulmonary function in normal subjects and patients with sarcoidosis after bronchoalveolar lavage. Chest. 1986 Feb; 89(2):244-8.
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  135. Custer JR, Hales CA. Chemical sympathectomy decreases alveolar hypoxic vasoconstriction in lambs but not in sheep. J Appl Physiol. 1986 Jan; 60(1):32-7.
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  136. Venegas JG, Custer J, Kamm RD, Hales CA. Relationship for gas transport during high-frequency ventilation in dogs. J Appl Physiol. 1985 Nov; 59(5):1539-47.
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  137. Hales CA. The site and mechanism of oxygen sensing for the pulmonary vessels. Chest. 1985 Oct; 88(4 Suppl):235S-240S.
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  138. Custer JR, Hales CA. Influence of alveolar oxygen on pulmonary vasoconstriction in newborn lambs versus sheep. Am Rev Respir Dis. 1985 Aug; 132(2):326-31.
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  139. Sprince NL, Chamberlin RI, Hales CA, Weber AL, Kazemi H. Respiratory disease in tungsten carbide production workers. Chest. 1984 Oct; 86(4):549-57.
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  140. Zapol WM, Wilson R, Hales C, Fish D, Castorena G, Hilgenberg A, Quinn D, Kradin R. Venovenous bypass with a membrane lung to support bilateral lung lavage. JAMA. 1984 Jun 22-29; 251(24):3269-71.
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  141. Hales CA, Kradin RL, Brandstetter RD, Zhu YJ. Impairment of hypoxic pulmonary artery remodeling by heparin in mice. Am Rev Respir Dis. 1983 Oct; 128(4):747-51.
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  142. Zhu YJ, Kradin R, Brandstetter RD, Staton G, Moss J, Hales CA. Hypoxic pulmonary hypertension in the mast cell-deficient mouse. J Appl Physiol. 1983 Mar; 54(3):680-6.
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  143. Braslow NM, Hales CA, Hoop B, Kanarek DJ, Kazemi H. Noninvasive cardiac output determination using inhaled oxygen-15-labeled carbon dioxide. J Appl Physiol. 1982 Nov; 53(5):1125-32.
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  144. Ahluwalia BD, Brownell GL, Hales CA, Kazemi H. An index of pulmonary edema measured with emission computed tomography. J Comput Assist Tomogr. 1981 Oct; 5(5):690-4.
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  145. Weiss RD, Goldenheim PD, Mirin SM, Hales CA, Mendelson JH. Pulmonary dysfunction in cocaine smokers. Am J Psychiatry. 1981 Aug; 138(8):1110-2.
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  146. Hales CA, Sonne L, Peterson M, Kong D, Miller M, Watkins WD. Role of thromboxane and prostacyclin in pulmonary vasomotor changes after endotoxin in dogs. J Clin Invest. 1981 Aug; 68(2):497-505.
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  147. Ahluwalia B, Brownell GL, Hales C, Kazemi H. Regional lung function evaluation with nitrogen-13. Eur J Nucl Med. 1981; 6(10):453-7.
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  148. Hales CA, Kanarek DJ, Ahluwalia B, Latty A, Erdmann J, Javaheri S, Kazemi H. Regional edema formation in isolated perfused dog lungs. Circ Res. 1981 Jan; 48(1):121-7.
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  149. Miller MA, Hales CA. Stability of alveolar hypoxic vasoconstriction with intermittent hypoxia. J Appl Physiol. 1980 Nov; 49(5):846-50.
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  150. Javaheri S, Hales CA. Sarcoidosis: a cause of innominate vein obstruction and massive pleural effusion. Lung. 1980; 157(2):81-5.
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  151. Blumenstock DA, Cannon FD, Hales CA, Vlahovic VL, Alpern H, Kazemi H. Pulmonary function of DLA-nonidentical lung allografts in dogs treated with lethal total-body irradiation, autologous bone marrow transplantation, and methotrexate. Transplantation. 1979 Sep; 28(3):223-7.
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  152. Miller MA, Hales CA. Role of cytochrome P-450 in alveolar hypoxic pulmonary vasoconstriction in dogs. J Clin Invest. 1979 Aug; 64(2):666-73.
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  153. Nichols AB, Cochavi S, Hales CA, Beller GA, Strauss HW. Resolution rates of pulmonary embolism assessed by serial positron imaging with inhaled O-15-labeled carbon dioxide. J Nucl Med. 1979 Apr; 20(4):281-6.
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  154. Hales CA, Westphal DM. Pulmonary hypoxic vasoconstriction: not affected by chemical sympathectomy. J Appl Physiol. 1979 Mar; 46(3):529-33.
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  155. Hales CA, Westphal D. Hypoxemia following the administration of sublingual nitroglycerin. Am J Med. 1978 Dec; 65(6):911-8.
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  156. Nichols AB, Cochavi S, Hales CA, Strauss HW, McKusick KA, Waltman AC, Beller GA. Scintigraphic detection of pulmonary emboli by serial positron imaging of inhaled 15O-labeled carbon dioxide. N Engl J Med. 1978 Aug 10; 299(6):279-84.
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  157. Hales CA, Rouse ET, Slate JL. Influence of aspirin and indomethacin on variability of alveolar hypoxic vasoconstriction. J Appl Physiol. 1978 Jul; 45(1):33-9.
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  158. Kazemi H, Hales C, Ahluwalia B. N13-N2(1). Prog Nucl Med. 1978; 5:93-114.
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  159. Hales CA, Rouse ET, Kazemi H. Failure of saralasin acetate, a competitive inhibitor of angiotensin II, to diminish alveolar hypoxic vasoconstriction in the dog. Cardiovasc Res. 1977 Nov; 11(6):541-6.
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  160. Hales CA, Kazemi H. Clinical significance of pulmonary function tests. Pulmonary function after uncomplicated myocardial infarction. Chest. 1977 Sep; 72(3):350-8.
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  161. Blumenstock DA, Cannon FD, Franck WA, Hales CA, Kazemi H, Ferrebee JW. Allotransplantation of the lung without immunosuppression after transplantation. II. Combined autotransplantation of bone marrow and allotransplantation of lung. Transplantation. 1977 Sep; 24(3):194-200.
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  162. Hales CA, Rouse E, Buchwald IA, Kazemi H. Role of prostaglandins in alveolar hypoxic vasoconstriction. Respir Physiol. 1977 Apr; 29(2):151-62.
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  163. Hales CA, Gibbons R, Burnham C, Kazemi H. Determinants of regional distribution of a bolus inhaled from residual volume. J Appl Physiol. 1976 Sep; 41(3):400-8.
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  164. Hales CA, Ahluwalia B, Kazemi H. Strength of pulmonary vascular response to regional alveolar hypoxia. J Appl Physiol. 1975 Jun; 38(6):1083-7.
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  165. Hales CA, Kazemi H. Role of histamine in the hypoxic vascular response of the lung. Respir Physiol. 1975 Jun; 24(1):81-8.
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  166. Chesler DA, Hales C, Hnatowich DJ, Hoop B. Three-dimensional reconstruction of lung perfusion image with positron detection. J Nucl Med. 1975 Jan; 16(1):80-2.
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  167. Blumenstock DA, Kazemi H, Hales CA, Cannon FD, Zumwalt R, Ferrebee J. Allotransplantation of lung without immunosuppression after transplantation. I. Staged transplantation of bone marrow and lung. Transplantation. 1974 Oct; 18(4):336-42.
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  168. Hales CA, Kazemi H. Hypoxic vascular response of the lung: effect of aminophylline and epinephrine. Am Rev Respir Dis. 1974 Aug; 110(2):126-32.
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  169. Hales CA, Kazemi H. Small-airways function in myocardial infarction. N Engl J Med. 1974 Apr 4; 290(14):761-5.
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  170. Kazemi H, Hales CA. Pulmonary vascular response to unilateral alveolar hypoxia: role of H+. Bull Physiopathol Respir (Nancy). 1974 Mar-Apr; 10(2):267-72.
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  171. Kanarek D, Zapol W, Ahluwalia B, Qvist J, Hales C, Liland A. Radionuclide imaging of the circulatory distribution of membrane lung perfusion. Trans Am Soc Artif Intern Organs. 1974; 20A:262-8.
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