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Bin Zhu, PH.D.

TitleResearch Fellow in Biological Chemistry and Molecular Pharmacology (INT)
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
AddressHarvard Medical School
B C M P, C2-221
240 Longwood Ave
Boston MA 02115

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhu B, Tabor S, Richardson CC. Syn5 RNA polymerase synthesizes precise run-off RNA products. Nucleic Acids Res. 2013 Nov 26.
    View in: PubMed
  2. Tan M, Zhu B, Liu RJ, Chen X, Zhou XL, Wang ED. Interdomain communication modulates the tRNA-dependent pre-transfer editing of leucyl-tRNA synthetase. Biochem J. 2013 Jan 1; 449(1):123-31.
    View in: PubMed
  3. Zhu B, Tabor S, Raytcheva DA, Hernandez A, King JA, Richardson CC. The RNA polymerase of marine cyanophage syn5. J Biol Chem. 2013 Feb 1; 288(5):3545-52.
    View in: PubMed
  4. Lee SJ, Zhu B, Akabayov B, Richardson CC. Zinc-binding Domain of the Bacteriophage T7 DNA Primase Modulates Binding to the DNA Template. J Biol Chem. 2012 Nov 9; 287(46):39030-40.
    View in: PubMed
  5. Zhang H, Lee SJ, Kulczyk AW, Zhu B, Richardson CC. Heterohexamer of 56- and 63-kDa Gene 4 Helicase-Primase of Bacteriophage T7 in DNA Replication. J Biol Chem. 2012 Oct 5; 287(41):34273-87.
    View in: PubMed
  6. Zhu B, Lee SJ, Tan M, Wang ED, Richardson CC. Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8050-5.
    View in: PubMed
  7. Zhu B, Lee SJ, Richardson CC. Bypass of a nick by the replisome of bacteriophage T7. J Biol Chem. 2011 Aug 12; 286(32):28488-97.
    View in: PubMed
  8. Zhang H, Lee SJ, Zhu B, Tran NQ, Tabor S, Richardson CC. Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis. Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23):9372-7.
    View in: PubMed
  9. Zhu B, Lee SJ, Richardson CC. Direct role for the RNA polymerase domain of T7 primase in primer delivery. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9099-104.
    View in: PubMed
  10. Lee SJ, Zhu B, Hamdan SM, Richardson CC. Mechanism of sequence-specific template binding by the DNA primase of bacteriophage T7. Nucleic Acids Res. 2010 Jul; 38(13):4372-83.
    View in: PubMed
  11. Tan M, Zhu B, Zhou XL, He R, Chen X, Eriani G, Wang ED. tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase. J Biol Chem. 2010 Jan 29; 285(5):3235-44.
    View in: PubMed
  12. Zhu B, Lee SJ, Richardson CC. An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities. J Biol Chem. 2009 Aug 28; 284(35):23842-51.
    View in: PubMed
  13. Akabayov B, Lee SJ, Akabayov SR, Rekhi S, Zhu B, Richardson CC. DNA recognition by the DNA primase of bacteriophage T7: a structure-function study of the zinc-binding domain. Biochemistry. 2009 Mar 3; 48(8):1763-73.
    View in: PubMed
  14. Zhou XL, Yao P, Ruan LL, Zhu B, Luo J, Qu LH, Wang ED. A unique insertion in the CP1 domain of Giardia lamblia leucyl-tRNA synthetase. Biochemistry. 2009 Feb 17; 48(6):1340-7.
    View in: PubMed
  15. Zhu B, Yao P, Tan M, Eriani G, Wang ED. tRNA-independent pretransfer editing by class I leucyl-tRNA synthetase. J Biol Chem. 2009 Feb 6; 284(6):3418-24.
    View in: PubMed
  16. Zhou XL, Zhu B, Wang ED. The CP2 domain of leucyl-tRNA synthetase is crucial for amino acid activation and post-transfer editing. J Biol Chem. 2008 Dec 26; 283(52):36608-16.
    View in: PubMed
  17. Yao P, Zhu B, Jaeger S, Eriani G, Wang ED. Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during the aminoacylation and editing steps. Nucleic Acids Res. 2008 May; 36(8):2728-38.
    View in: PubMed
  18. Zhu B, Zhao MW, Eriani G, Wang ED. A present-day aminoacyl-tRNA synthetase with ancestral editing properties. RNA. 2007 Jan; 13(1):15-21.
    View in: PubMed
  19. Liu Y, Liao J, Zhu B, Wang ED, Ding J. Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination. Biochem J. 2006 Mar 1; 394(Pt 2):399-407.
    View in: PubMed
  20. Zhao MW, Zhu B, Hao R, Xu MG, Eriani G, Wang ED. Leucyl-tRNA synthetase from the ancestral bacterium Aquifex aeolicus contains relics of synthetase evolution. EMBO J. 2005 Apr 6; 24(7):1430-9.
    View in: PubMed
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