Samuel David Rabkin, PH.D.
|Title||Thomas A. Pappas Professor of Neurosciences|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Brain Tumor Research Ctr, Simches, CPZN-3800
185 Cambridge St
Boston MA 02114
Available: 05/01/12, Expires: 09/01/14
We are isolating glioblastoma stem cells from patient specimens and characterizing their biology and susceptibility to novel therapeutics. Oncolytic herpes simplex viruses are genetically mutated viruses that replicate selectively in cancer cells and not normal cells, and are being developed to treat glioblastoma patients.
Available: 09/03/12, Expires: 08/29/14
Volunteer research opportunities for medical students, preferably with some laboratory-based research experience, in the Brain Tumor Research Center, Simches Research Building, MGH.
Students will learn a technique related to on-going studies and perform experiments under the supervision of experienced laboratory members.
Our laboratory focuses on the use of oncolytic herpes simplex virus (oHSV) vectors for cancer therapy. A number of different vector strategies are being developed: (i) oHSV vectors mutated in different viral genes to target the cancer cell phenotype due to physiologic/signaling pathway differences with 'normal' cells; (ii) recombinant oHSV vectors expressing therapeutic transgenes; and (iii) transcriptionally-regulated oHSV vectors that are targeted by cancer-specific gene expression. These vectors are characterized in a range of tumor models; human tumor xenografts in nude mice, mouse tumors in syngeneic mice, cancer stem cells, and transgenic mouse tumor models. We are exploring a number of therapeutic strategies: (i) oHSV in combination with chemotherapeutics or other compounds with synergistic interactions; (ii) targeting the tumor microenvironment using 'armed' oHSV; and (iii) immunotherapy approaches, including ex vivo activated dendritic cells.
Infection Study of Human Neural Stem Cells with Oncolytic HSV
Summer, 04/02/07 - 08/03/07
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