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Rebecca E. Hussey, M.S.

TitleResearch Associate in Pathology
InstitutionDana-Farber Cancer Institute
DepartmentPathology
AddressHarvard Institutes of Medicine
Dfci - Him 404
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/632-3813
Fax617/632-3351

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Reche PA, Keskin DB, Hussey RE, Ancuta P, Gabuzda D, Reinherz EL. Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes. Med Immunol. 2006; 5:1.
    View in: PubMed
  2. Kim M, Yang H, Kim SK, Reche PA, Tirabassi RS, Hussey RE, Chishti Y, Rheinwald JG, Morehead TJ, Zech T, Damon IK, Welsh RM, Reinherz EL. Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies. J Biol Chem. 2004 Jun 11; 279(24):25838-48.
    View in: PubMed
  3. Fiorini E, Schmitz I, Marissen WE, Osborn SL, Touma M, Sasada T, Reche PA, Tibaldi EV, Hussey RE, Kruisbeek AM, Reinherz EL, Clayton LK. Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol Cell. 2002 Mar; 9(3):637-48.
    View in: PubMed
  4. Kim M, Chen B, Hussey RE, Chishti Y, Montefiori D, Hoxie JA, Byron O, Campbell G, Harrison SC, Reinherz EL. The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. J Biol Chem. 2001 Nov 16; 276(46):42667-76.
    View in: PubMed
  5. Zhang CW, Chishti Y, Hussey RE, Reinherz EL. Expression, purification, and characterization of recombinant HIV gp140. The gp41 ectodomain of HIV or simian immunodeficiency virus is sufficient to maintain the retroviral envelope glycoprotein as a trimer. J Biol Chem. 2001 Oct 26; 276(43):39577-85.
    View in: PubMed
  6. Fukai I, Hussey RE, Sunder-Plassmann R, Reinherz EL. A critical role for p59(fyn) in CD2-based signal transduction. Eur J Immunol. 2000 Dec; 30(12):3507-15.
    View in: PubMed
  7. Chen B, Zhou G, Kim M, Chishti Y, Hussey RE, Ely B, Skehel JJ, Reinherz EL, Harrison SC, Wiley DC. Expression, purification, and characterization of gp160e, the soluble, trimeric ectodomain of the simian immunodeficiency virus envelope glycoprotein, gp160. J Biol Chem. 2000 Nov 10; 275(45):34946-53.
    View in: PubMed
  8. Sakihama T, Hunsicker ME, Hussey RE, Reinherz EL. Human CD4 residue Phe 43 is critical for repertoire development and maturation of MHC class II restricted CD4 single-positive T lineage cells in vivo. Eur J Immunol. 2000 Jan; 30(1):279-90.
    View in: PubMed
  9. Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, Wang J. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science. 1999 Dec 3; 286(5446):1913-21.
    View in: PubMed
  10. Kern P, Hussey RE, Spoerl R, Reinherz EL, Chang HC. Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers. J Biol Chem. 1999 Sep 17; 274(38):27237-43.
    View in: PubMed
  11. Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL. A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. EMBO J. 1998 Dec 15; 17(24):7320-36.
    View in: PubMed
  12. Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH. Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity. 1998 Oct; 9(4):519-30.
    View in: PubMed
  13. Teng MK, Smolyar A, Tse AG, Liu JH, Liu J, Hussey RE, Nathenson SG, Chang HC, Reinherz EL, Wang JH. Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes. Curr Biol. 1998 Mar 26; 8(7):409-12.
    View in: PubMed
  14. Wang J, Lim K, Smolyar A, Teng M, Liu J, Tse AG, Liu J, Hussey RE, Chishti Y, Thomson CT, Sweet RM, Nathenson SG, Chang HC, Sacchettini JC, Reinherz EL. Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. EMBO J. 1998 Jan 2; 17(1):10-26.
    View in: PubMed
  15. Ghendler Y, Hussey RE, Witte T, Mizoguchi E, Clayton LK, Bhan AK, Koyasu S, Chang HC, Reinherz EL. Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol. 1997 Sep; 27(9):2279-89.
    View in: PubMed
  16. Liu J, Tse AG, Chang HC, Liu Jh, Wang J, Hussey RE, Chishti Y, Rheinhold B, Spoerl R, Nathenson SG, Sacchettini JC, Reinherz EL. Crystallization of a deglycosylated T cell receptor (TCR) complexed with an anti-TCR Fab fragment. J Biol Chem. 1996 Dec 27; 271(52):33639-46.
    View in: PubMed
  17. Koyasu S, Tse AG, Moingeon P, Hussey RE, Mildonian A, Hannisian J, Clayton LK, Reinherz EL. Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains. Proc Natl Acad Sci U S A. 1994 Jul 5; 91(14):6693-7.
    View in: PubMed
  18. Koyasu S, Hussey RE, Clayton LK, Lerner A, Pedersen R, Delany-Heiken P, Chau F, Reinherz EL. Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse. EMBO J. 1994 Feb 15; 13(4):784-97.
    View in: PubMed
  19. Hussey RE, Clayton LK, Diener A, McConkey DJ, Howard FD, Rodewald HR, D'Adamio L, Dallenbach F, Stein H, Schmidt EV, et al. Overexpression of CD3 eta during thymic development does not alter the negative selection process. J Immunol. 1993 Feb 15; 150(4):1183-94.
    View in: PubMed
  20. Clayton LK, Lerner A, Diener AC, Hussey RE, Koyasu S, Reinherz EL. T-cell-receptor isoforms. Int J Cancer Suppl. 1992; 7:1-5.
    View in: PubMed
  21. Novotny J, Ganju RK, Smiley ST, Hussey RE, Luther MA, Recny MA, Siliciano RF, Reinherz EL. A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties. Proc Natl Acad Sci U S A. 1991 Oct 1; 88(19):8646-50.
    View in: PubMed
  22. Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL. CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5202-6.
    View in: PubMed
  23. Sayre PH, Hussey RE, Chang HC, Ciardelli TL, Reinherz EL. Structural and binding analysis of a two domain extracellular CD2 molecule. J Exp Med. 1989 Mar 1; 169(3):995-1009.
    View in: PubMed
  24. Clayton LK, Hussey RE, Steinbrich R, Ramachandran H, Husain Y, Reinherz EL. Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding. Nature. 1988 Sep 22; 335(6188):363-6.
    View in: PubMed
  25. Richardson NE, Brown NR, Hussey RE, Vaid A, Matthews TJ, Bolognesi DP, Reinherz EL. Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):6102-6.
    View in: PubMed
  26. Richardson NE, Chang HC, Brown NR, Hussey RE, Sayre PH, Reinherz EL. Adhesion domain of human T11 (CD2) is encoded by a single exon. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5176-80.
    View in: PubMed
  27. Alcover A, Chang HC, Sayre PH, Hussey RE, Reinherz EL. The T 11 (CD 2) cDNA encodes a transmembrane protein which expresses T 11(1), T 11(2) and T 11(3) epitopes but which does not independently mediate calcium influx: analysis by gene transfer in a baculovirus system. Eur J Immunol. 1988 Mar; 18(3):363-7.
    View in: PubMed
  28. Hussey RE, Richardson NE, Kowalski M, Brown NR, Chang HC, Siliciano RF, Dorfman T, Walker B, Sodroski J, Reinherz EL. A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature. 1988 Jan 7; 331(6151):78-81.
    View in: PubMed
  29. Ritz J, Campen TJ, Schmidt RE, Royer HD, Hercend T, Hussey RE, Reinherz EL. Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones. Science. 1985 Jun 28; 228(4707):1540-3.
    View in: PubMed
  30. Reinherz EL, Hussey RE, Fitzgerald K, Snow P, Terhorst C, Schlossman SF. Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes. Nature. 1981 Nov 12; 294(5837):168-70.
    View in: PubMed
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