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Eleftheria Maratos-Flier, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressCenter for Life Science
Endocrine Division, CLS 7
3 Blackfan Circle
Boston MA 02115
Phone617/735-3289
Fax617/735-3343
Other Positions
TitleAssociate Master of Francis Weld Peabody Society
InstitutionHarvard Medical School
DepartmentPME


 Mentoring 
 current student opportunities
Available: 10/01/12, Expires: 09/30/13

My lab has a range of opportunities from clinical studies in the regulation of appetite and metabolism to basic bench studies looking at molecular mediators of food intake and energy expenditure in mouse models. We are interested obesity, diabetes and anorexia nervosa. We are also interested on the effect of dietary composition on metabolism.

 completed student projects
Effects of Varying Dietary Composition of Fat in Melanin-concentrating Hormone Overexpressing mice
Summer, 06/17/00 - 08/17/00
Induction of C/EBP-beta by Fibroblast Growth Factor 21 in Mouse Liver
Summer, 06/25/12 - 08/10/12
Effects of Varying Dietary Composition of Fat in Melanin-Concentrating Hormone Overexpressing Mice
Part Time/Continuation, 01/03/01 - 05/31/01
Prospective Randomized Comparison of Pre-fabricated Neoprene Splinting Versus Custom-made Thermoplast Splinting for Thumb Carpometacarpal Joint Arthritis
Summer, 06/19/06 - 08/11/06
Physician Use of Brand vs. Generic Drug Names in the United States from 1993 to 2004
Summer, 06/19/06 - 08/25/06
A Prospective Cohort Study Comparing Metabolic Status Following Off-Pump Coronary Artery Bypass Grafting versus On-Pump Coronary Artery Bypass Grafting
Summer, 06/15/09 - 08/14/09

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Douris N, Maratos-Flier E. Two paths diverge in the brain: melanin-concentrating hormone controls hepatic and adipose metabolism. Gastroenterology. 2013 Mar; 144(3):501-4.
    View in: PubMed
  2. Fisher FM, Maratos-Flier E. Stress heats up the adipocyte. Nat Med. 2013 Jan; 19(1):17-8.
    View in: PubMed
  3. Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012 Feb 1; 26(3):271-81.
    View in: PubMed
  4. Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. Nat Methods. 2012 Jan; 9(1):57-63.
    View in: PubMed
  5. McNay DE, Briançon N, Kokoeva MV, Maratos-Flier E, Flier JS. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest. 2012 Jan 3; 122(1):142-52.
    View in: PubMed
  6. Vella KR, Ramadoss P, Lam FS, Harris JC, Ye FD, Same PD, O'Neill NF, Maratos-Flier E, Hollenberg AN. NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Cell Metab. 2011 Dec 7; 14(6):780-90.
    View in: PubMed
  7. Dushay J, Gao C, Gopalakrishnan GS, Crawley M, Mitten EK, Wilker E, Mullington J, Maratos-Flier E. Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes. Diabetes Care. 2012 Jan; 35(1):4-11.
    View in: PubMed
  8. Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 2011 Aug; 152(8):2996-3004.
    View in: PubMed
  9. Adams AC, Domouzoglou EM, Chee MJ, Segal-Lieberman G, Pissios P, Maratos-Flier E. Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration. Behav Brain Res. 2011 Oct 10; 224(1):195-200.
    View in: PubMed
  10. Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest. 2011 Apr; 121(4):1424-8.
    View in: PubMed
  11. Eguchi J, Wang X, Yu S, Kershaw EE, Chiu PC, Dushay J, Estall JL, Klein U, Maratos-Flier E, Rosen ED. Transcriptional control of adipose lipid handling by IRF4. Cell Metab. 2011 Mar 2; 13(3):249-59.
    View in: PubMed
  12. Domouzoglou EM, Maratos-Flier E. Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. Am J Clin Nutr. 2011 Apr; 93(4):901S-5.
    View in: PubMed
  13. Aboulaich N, Chui PC, Asara JM, Flier JS, Maratos-Flier E. Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism. Diabetes. 2011 Mar; 60(3):757-65.
    View in: PubMed
  14. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan 6; 469(7328):102-6.
    View in: PubMed
  15. Flier JS, Maratos-Flier E. Lasker lauds leptin. Cell Metab. 2010 Oct 6; 12(4):317-20.
    View in: PubMed
  16. Flier JS, Maratos-Flier E. Lasker lauds leptin. Cell. 2010 Oct 1; 143(1):9-12.
    View in: PubMed
  17. Briancon N, McNay DE, Maratos-Flier E, Flier JS. Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance. Diabetes. 2010 Dec; 59(12):3074-84.
    View in: PubMed
  18. Fisher FM, Chui PC, Antonellis PJ, Bina HA, Kharitonenkov A, Flier JS, Maratos-Flier E. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes. 2010 Nov; 59(11):2781-9.
    View in: PubMed
  19. Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010 Jul 1; 185(1):517-24.
    View in: PubMed
  20. Dushay J, Chui PC, Gopalakrishnan GS, Varela-Rey M, Crawley M, Fisher FM, Badman MK, Martinez-Chantar ML, Maratos-Flier E. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology. 2010 Aug; 139(2):456-63.
    View in: PubMed
  21. Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS, Hollenberg AN, Maratos-Flier E. Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem. 2010 May 7; 285(19):14078-82.
    View in: PubMed
  22. Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22510-5.
    View in: PubMed
  23. Glier MB, Pissios P, Babich SL, Macdonald ML, Hayden MR, Maratos-Flier E, Gibson WT. The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone. Peptides. 2010 Jan; 31(1):123-9.
    View in: PubMed
  24. Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology. 2009 Nov; 150(11):4931-40.
    View in: PubMed
  25. Badman MK, Kennedy AR, Adams AC, Pissios P, Maratos-Flier E. A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1197-204.
    View in: PubMed
  26. Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine AB. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring). 2009 Sep; 17(9):1671-7.
    View in: PubMed
  27. Zhang R, Maratos-Flier E, Flier JS. Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. Endocrinology. 2009 Jul; 150(7):3076-82.
    View in: PubMed
  28. Willie JT, Sinton CM, Maratos-Flier E, Yanagisawa M. Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression. Neuroscience. 2008 Oct 28; 156(4):819-29.
    View in: PubMed
  29. Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008 Nov; 149(11):5654-61.
    View in: PubMed
  30. Kokkotou E, Moss AC, Torres D, Karagiannides I, Cheifetz A, Liu S, O'Brien M, Maratos-Flier E, Pothoulakis C. Melanin-concentrating hormone as a mediator of intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10613-8.
    View in: PubMed
  31. Bradley RL, Jeon JY, Liu FF, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2008 Sep; 295(3):E586-94.
    View in: PubMed
  32. Maratos-Flier E. The long reach of leptin. Nat Med. 2008 Jun; 14(6):604-6.
    View in: PubMed
  33. Bradley RL, Fisher FF, Maratos-Flier E. Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes. Obesity (Silver Spring). 2008 May; 16(5):938-44.
    View in: PubMed
  34. Pissios P, Frank L, Kennedy AR, Porter DR, Marino FE, Liu FF, Pothos EN, Maratos-Flier E. Dysregulation of the mesolimbic dopamine system and reward in MCH-/- mice. Biol Psychiatry. 2008 Aug 1; 64(3):184-91.
    View in: PubMed
  35. Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, Kahn CR. Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell. 2007 Dec; 6(6):827-39.
    View in: PubMed
  36. Pissios P, Maratos-Flier E. More than satiety: central serotonin signaling and glucose homeostasis. Cell Metab. 2007 Nov; 6(5):345-7.
    View in: PubMed
  37. Flier JS, Maratos-Flier E. What fuels fat. Sci Am. 2007 Sep; 297(3):72-81.
    View in: PubMed
  38. Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem. 2007 Oct 12; 282(41):30014-21.
    View in: PubMed
  39. Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007 Jun; 5(6):426-37.
    View in: PubMed
  40. Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos-Flier E. A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1724-39.
    View in: PubMed
  41. Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 2007 Feb; 56(2):311-9.
    View in: PubMed
  42. Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron. 2006 Sep 21; 51(6):811-22.
    View in: PubMed
  43. Pissios P, Bradley RL, Maratos-Flier E. Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions. Endocr Rev. 2006 Oct; 27(6):606-20.
    View in: PubMed
  44. Jeon JY, Bradley RL, Kokkotou EG, Marino FE, Wang X, Pissios P, Maratos-Flier E. MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance. Diabetes. 2006 Feb; 55(2):428-34.
    View in: PubMed
  45. Bradley RL, Mansfield JP, Maratos-Flier E. Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes. Obes Res. 2005 Apr; 13(4):653-61.
    View in: PubMed
  46. Georgescu D, Sears RM, Hommel JD, Barrot M, Bolaños CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ, DiLeone RJ. The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci. 2005 Mar 16; 25(11):2933-40.
    View in: PubMed
  47. Kokkotou E, Jeon JY, Wang X, Marino FE, Carlson M, Trombly DJ, Maratos-Flier E. Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. Am J Physiol Regul Integr Comp Physiol. 2005 Jul; 289(1):R117-24.
    View in: PubMed
  48. Bates SH, Dundon TA, Seifert M, Carlson M, Maratos-Flier E, Myers MG. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes. 2004 Dec; 53(12):3067-73.
    View in: PubMed
  49. Blüher S, Moschos S, Bullen J, Kokkotou E, Maratos-Flier E, Wiegand SJ, Sleeman MW, Sleemann MW, Mantzoros CS. Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice. Diabetes. 2004 Nov; 53(11):2787-96.
    View in: PubMed
  50. Bullen JW, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, Mantzoros CS. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am J Physiol Endocrinol Metab. 2004 Oct; 287(4):E662-70.
    View in: PubMed
  51. Gibson WT, Pissios P, Trombly DJ, Luan J, Keogh J, Wareham NJ, Maratos-Flier E, O'Rahilly S, Farooqi IS. Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. Obes Res. 2004 May; 12(5):743-9.
    View in: PubMed
  52. Tritos NA, Segal-Lieberman G, Vezeridis PS, Maratos-Flier E. Estradiol-induced anorexia is independent of leptin and melanin-concentrating hormone. Obes Res. 2004 Apr; 12(4):716-24.
    View in: PubMed
  53. Blüher S, Ziotopoulou M, Bullen JW, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS. Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes. 2004 Jan; 53(1):82-90.
    View in: PubMed
  54. Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG, Flier JS, Maratos-Flier E. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10085-90.
    View in: PubMed
  55. Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E. Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways. Endocrinology. 2003 Aug; 144(8):3514-23.
    View in: PubMed
  56. Tritos NA, Mun E, Bertkau A, Grayson R, Maratos-Flier E, Goldfine A. Serum ghrelin levels in response to glucose load in obese subjects post-gastric bypass surgery. Obes Res. 2003 Aug; 11(8):919-24.
    View in: PubMed
  57. Pissios P, Maratos-Flier E. Melanin-concentrating hormone: from fish skin to skinny mammals. Trends Endocrinol Metab. 2003 Jul; 14(5):243-8.
    View in: PubMed
  58. Tritos NA, Kokkinos A, Lampadariou E, Alexiou E, Katsilambros N, Maratos-Flier E. Cerebrospinal fluid ghrelin is negatively associated with body mass index. J Clin Endocrinol Metab. 2003 Jun; 88(6):2943-6.
    View in: PubMed
  59. Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 2003 Feb 20; 421(6925):856-9.
    View in: PubMed
  60. Segal-Lieberman G, Trombly DJ, Juthani V, Wang X, Maratos-Flier E. NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fasting. Am J Physiol Endocrinol Metab. 2003 Jun; 284(6):E1131-9.
    View in: PubMed
  61. Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. Brain Res. 2003 Jan 31; 961(2):255-60.
    View in: PubMed
  62. Bradley RL, Mansfield JP, Maratos-Flier E, Cheatham B. Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2002 Sep; 283(3):E584-92.
    View in: PubMed
  63. Flier JS, Maratos-Flier E. The stomach speaks--ghrelin and weight regulation. N Engl J Med. 2002 May 23; 346(21):1662-3.
    View in: PubMed
  64. Tritos NA, Mastaitis JW, Kokkotou E, Maratos-Flier E. Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res. 2001 Mar 23; 895(1-2):160-6.
    View in: PubMed
  65. Mobbs CV, Bray GA, Atkinson RL, Bartke A, Finch CE, Maratos-Flier E, Crawley JN, Nelson JF. Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span. J Gerontol A Biol Sci Med Sci. 2001 Mar; 56 Spec No 1:34-44.
    View in: PubMed
  66. Kokkotou EG, Tritos NA, Mastaitis JW, Slieker L, Maratos-Flier E. Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology. 2001 Feb; 142(2):680-6.
    View in: PubMed
  67. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001 Feb; 107(3):379-86.
    View in: PubMed
  68. Bradley RL, Kokkotou EG, Maratos-Flier E, Cheatham B. Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes. Diabetes. 2000 Jul; 49(7):1073-7.
    View in: PubMed
  69. Kokkotou E, Mastaitis JW, Qu D, Hoersch D, Slieker L, Bonter K, Tritos NA, Maratos-Flier E. Characterization of [Phe(13), Tyr(19)]-MCH analog binding activity to the MCH receptor. Neuropeptides. 2000 Jun-Aug; 34(3-4):240-7.
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  70. Flier J, Maratos-Flier E. Energy homeostasis and body weight. Curr Biol. 2000 Mar 23; 10(6):R215-7.
    View in: PubMed
  71. Vicent D, Maratos-Flier E, Kahn CR. The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. Mol Cell Biol. 2000 Mar; 20(6):2158-66.
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  72. Tritos NA, Maratos-Flier E. Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone. Neuropeptides. 1999 Oct; 33(5):339-49.
    View in: PubMed
  73. Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol. 1998 Dec 28; 402(4):442-59.
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  74. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998 Dec 17; 396(6712):670-4.
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  75. Tritos NA, Vicent D, Gillette J, Ludwig DS, Flier ES, Maratos-Flier E. Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. Diabetes. 1998 Nov; 47(11):1687-92.
    View in: PubMed
  76. Tritos NA, Elmquist JK, Mastaitis JW, Flier JS, Maratos-Flier E. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Endocrinology. 1998 Nov; 139(11):4634-41.
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  77. Elmquist JK, Maratos-Flier E, Saper CB, Flier JS. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci. 1998 Oct; 1(6):445-50.
    View in: PubMed
  78. Vicent D, Piper M, Gammeltoft S, Maratos-Flier E, Kahn CR. Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display. Diabetes. 1998 Sep; 47(9):1451-8.
    View in: PubMed
  79. Ludwig DS, Mountjoy KG, Tatro JB, Gillette JA, Frederich RC, Flier JS, Maratos-Flier E. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am J Physiol. 1998 Apr; 274(4 Pt 1):E627-33.
    View in: PubMed
  80. Flier JS, Maratos-Flier E. Obesity and the hypothalamus: novel peptides for new pathways. Cell. 1998 Feb 20; 92(4):437-40.
    View in: PubMed
  81. Mantzoros CS, Frederich RC, Qu D, Lowell BB, Maratos-Flier E, Flier JS. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes. 1998 Feb; 47(2):230-8.
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  82. Maratos-Flier E. Reovirus and endocrine cells. Curr Top Microbiol Immunol. 1998; 233(Pt 2):85-91.
    View in: PubMed
  83. Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS, Saper CB. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology. 1997 Feb; 138(2):839-42.
    View in: PubMed
  84. Maratos-Flier E, Qu D, Gammeltoft S. Analysis of gene expression in hypothalamus in obese and normal mice using differential display. Methods Mol Biol. 1997; 85:297-304.
    View in: PubMed
  85. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature. 1996 Jul 18; 382(6588):250-2.
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  86. Mantzoros CS, Qu D, Frederich RC, Susulic VS, Lowell BB, Maratos-Flier E, Flier JS. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes. 1996 Jul; 45(7):909-14.
    View in: PubMed
  87. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 1996 Mar 21; 380(6571):243-7.
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  88. el-Ghorr AA, Gordon DA, George K, Maratos-Flier E. Regulation of expression of the reovirus receptor on differentiated HL60 cells. J Gen Virol. 1992 Aug; 73 ( Pt 8):1961-8.
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  89. Montgomery LB, Kao CY, Verdin E, Cahill C, Maratos-Flier E. Infection of a polarized epithelial cell line with wild-type reovirus leads to virus persistence and altered cellular function. J Gen Virol. 1991 Dec; 72 ( Pt 12):2939-46.
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  90. Verdin EM, King GL, Maratos-Flier E. Characterization of a common high-affinity receptor for reovirus serotypes 1 and 3 on endothelial cells. J Virol. 1989 Mar; 63(3):1318-25.
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  91. Verdin EM, Lynn SP, Fields BN, Maratos-Flier E. Uptake of reovirus serotype 1 by the lungs from the bloodstream is mediated by the viral hemagglutinin. J Virol. 1988 Feb; 62(2):545-51.
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  92. Maratos-Flier E, Kao CY, Verdin EM, King GL. Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells. J Cell Biol. 1987 Oct; 105(4):1595-601.
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  93. Verdin EM, Maratos-Flier E, Kahn CR, Sodoyez JC, Sodoyez-Goffaux F, De Vos CJ, Lynn SP, Fields BN. Visualization of viral clearance in the living animal. Science. 1987 Apr 24; 236(4800):439-42.
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  94. Maratos-Flier E, Goodman MJ, Murray AH, Kahn CR. Ammonium inhibits processing and cytotoxicity of reovirus, a nonenveloped virus. J Clin Invest. 1986 Oct; 78(4):1003-7.
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  95. Verdin EM, Maratos-Flier E, Carpentier JL, Kahn CR. Persistent infection with a nontransforming RNA virus leads to impaired growth factor receptors and response. J Cell Physiol. 1986 Sep; 128(3):457-65.
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  96. Maratos-Flier E, Goodman MJ, Fields BN, Kahn CR. Differential effects of viral infection on islet and pituitary cell lines. Endocrinology. 1985 Jun; 116(6):2430-7.
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  97. Maratos-Flier E, Kahn CR, Spriggs DR, Fields BN. Specific plasma membrane receptors for reovirus on rat pituitary cells in culture. J Clin Invest. 1983 Aug; 72(2):617-21.
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  98. Flier JS, Maratos-Flier E, Pallotta JA, McIsaac D. Endogenous digitalis-like activity in the plasma of the toad Bufo marinus. Nature. 1979 May 24; 279(5711):341-3.
    View in: PubMed
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