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Mikhail Ivanovich Papisov, PH.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressShriners Hospitals for Children - Boston
Rm 224
51 Blossom St
Boston MA 02114
Phone617/724-9655

 Biography 
 awards and honors
2012 - Outstanding Pharmaceutical Paper Award

 Overview 
 overview
Research focus: Investigation of in vivo transport processes; development and characterization of macromolecular and supramolecular therapeutics, novel biomaterials; drug delivery to cancer and CNS.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Papisov MI, Belov VV, Gannon KS. Physiology of the intrathecal bolus: the leptomeningeal route for macromolecule and particle delivery to CNS. Mol Pharm. 2013 May 6; 10(5):1522-32.
    View in: PubMed
  2. Mushti C, Papisov MI. Radioiodination of aryl-alkyl cyclic sulfates. Molecules. 2012; 17(11):13266-74.
    View in: PubMed
  3. Papisov M, Belov V, Fischman A.J., Belova E, Titus J, Gagne M., Gillooly C. Delivery of proteins to CNS as seen and measured by Positron Emission Tomography. Drug Delivery and Translational Research. 2012; 2(3):201-209.
  4. Papisov M, Belov V, Belova E, Fischman A.J., Fisher R, Wright J, Ganon K, Titus J, Gagne M., Gillooly C. Investigation of intrathecal transport of NPT002, a prospective therapeutic based on phage M13, in non-human primates. Drug Delivery and Translational Research. 2012; 2(3):210-221.
  5. Calias P, Papisov M, Pan J, Savioli N, Belov V, Huang Y, Lotterhand J, Alessandrini M, Liu N, Fischman AJ, Powell JL, Heartlein MW. CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder. PLoS One. 2012; 7(1):e30341.
    View in: PubMed
  6. Chandra Mushti and Mikhail I. Papisov. Molecules. Radioiodination of Aryl-Alkyl Cyclic Sulfates. 2012; 17(11):13266-13274.
  7. Belov VV, Bonab AA, Fischman AJ, Heartlein M, Calias P, Papisov MI. Iodine-124 as a label for pharmacological PET imaging. Mol Pharm. 2011 Jun 6; 8(3):736-47.
    View in: PubMed
  8. Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG. Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma. PLoS One. 2007; 2(12):e1356.
    View in: PubMed
  9. Yurkovetskiy A, Choi S, Hiller A, Yin M, McCusker C, Syed S, Fischman AJ, Papisov MI. Fully degradable hydrophilic polyals for protein modification. Biomacromolecules. 2005 Sep-Oct; 6(5):2648-58.
    View in: PubMed
  10. Papisov MI, Hiller A, Yurkovetskiy A, Yin M, Barzana M, Hillier S, Fischman AJ. Semisynthetic hydrophilic polyals. Biomacromolecules. 2005 Sep-Oct; 6(5):2659-70.
    View in: PubMed
  11. Papisov MI, Yurkovetskiy A, Syed S, Koshkina N, Yin M, Hiller A, Fischman AJ. A systemic route for drug loading to lymphatic phagocytes. Mol Pharm. 2005 Jan-Feb; 2(1):47-56.
    View in: PubMed
  12. Yurkovetskiy AV, Hiller A, Syed S, Yin M, Lu XM, Fischman AJ, Papisov MI. Synthesis of a macromolecular camptothecin conjugate with dual phase drug release. Mol Pharm. 2004 Sep-Oct; 1(5):375-82.
    View in: PubMed
  13. Papisov MI. Theoretical considerations of RES-avoiding liposomes: Molecular mechanics and chemistry of liposome interactions. Adv Drug Deliv Rev. 1998 Jun 8; 32(1-2):119-138.
    View in: PubMed
  14. Harika L, Weissleder R, Poss K, Papisov MI. Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies. Radiology. 1996 Feb; 198(2):365-70.
    View in: PubMed
  15. Papisov M, Weissleder R. Drug delivery to lymphatic tissue. Crit Rev Ther Drug Carrier Syst. 1996; 13(1-2):57-84.
    View in: PubMed
  16. Frank H, Weissleder R, Papisov M. [Presentation and quantification of acute myocardial infarct using antibody-bound MR contrast medium]. Z Kardiol. 1995 Apr; 84(4):311-5.
    View in: PubMed
  17. Papisov MI. Adv. Drug Delivery Rev. Modeling in vivo transfer of long-circulating polymers (two classes of long circulating polymers and factors affecting their transfer in vivo). 1995; 16:127-137.
  18. Harika L, Weissleder R, Poss K, Zimmer C, Papisov MI, Brady TJ. MR lymphography with a lymphotropic T1-type MR contrast agent: Gd-DTPA-PGM. Magn Reson Med. 1995 Jan; 33(1):88-92.
    View in: PubMed
  19. van Everdingen KJ, Enochs WS, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R. Determinants of in vivo MR imaging of slow axonal transport. Radiology. 1994 Nov; 193(2):485-91.
    View in: PubMed
  20. Torchilin VP, Omelyanenko VG, Papisov MI, Bogdanov AA, Trubetskoy VS, Herron JN, Gentry CA. Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. Biochim Biophys Acta. 1994 Oct 12; 1195(1):11-20.
    View in: PubMed
  21. Weissleder R, Heautot JF, Schaffer BK, Nossiff N, Papisov MI, Bogdanov A, Brady TJ. MR lymphography: study of a high-efficiency lymphotrophic agent. Radiology. 1994 Apr; 191(1):225-30.
    View in: PubMed
  22. Torchilin VP, Papisov MI. Why do PEG-coated liposomes circulate long?. J. Liposome Res. 1994; 4:725-739.
  23. Garrido L, Pfleiderer B, Papisov M, Ackerman JL. In vivo degradation of silicones. Magn Reson Med. 1993 Jun; 29(6):839-43.
    View in: PubMed
  24. Shen T, Weissleder R, Papisov M, Bogdanov A, Brady TJ. Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med. 1993 May; 29(5):599-604.
    View in: PubMed
  25. Schaffer BK, Linker C, Papisov M, Tsai E, Nossiff N, Shibata T, Bogdanov A, Brady TJ, Weissleder R. MION-ASF: biokinetics of an MR receptor agent. Magn Reson Imaging. 1993; 11(3):411-7.
    View in: PubMed
  26. Papisov MI, Sinitsyn VE Shchipanova, IV, Sergienko VB, Belenkov YuN. Experimental use of magnetite colloid solution as a supramagentic parenteral and oral contrast agent in magentic resonance tomography. Medical Radiology and Radiation Safety (Rus). 1993; 38(11):4-7.
  27. Enochs WS, Schaffer B, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Jr, Brady TJ, Weissleder R. MR imaging of slow axonal transport in vivo. Exp Neurol. 1993; 123:235-242.
  28. Weissleder R, Bogdanov A, Papisov M. Drug targeting in magnetic resonance imaging. Magn Reson Q. 1992 Mar; 8(1):55-63.
    View in: PubMed
  29. Papisov MI, Svel'ev VIu, Segienko VB, Torchilin VP. [Biokinetics of magnetic carriers for directed transport of drugs]. Antibiot Khimioter. 1988 Oct; 33(10):744-51.
    View in: PubMed
  30. Papisov MI, Torchilin VP. [Prediction of the biological effect of magnetically regulated drugs]. Antibiot Khimioter. 1988 Oct; 33(10):751-7.
    View in: PubMed
  31. Torchilin VP, Papisov MI, Orekhova NM, Belyaev AA, Petrov AD, Ragimov SE. Magnetically driven thrombolytic preparation containing immobilized streptokinase-targeted transport and action. Haemostasis. 1988; 18(2):113-6.
    View in: PubMed
  32. Papisov MI, Savelyev VY, Sergienko VB, Torchilin VP. Magnetic drug targeting (I) In vivo kinetics of radiolabeled magnetic drug carriers. Int. J. Pharm. 1987; 40:201-206.
  33. Papisov MI, Torchilin VP. Magnetic drug targeting (II) Targeted drug transport by magnetic microparticles: factors influencing therapeutic effect. Int. J. Pharm. 1987; 40:207-214.
  34. Torchilin VP, Maksimenko AV, Tishchenko EG, Papisov MI, Smirnov VN. [Drug preparations of immobilized enzymes with enhanced affinity for the site of action]. Antibiot Med Biotekhnol. 1986 Feb; 31(2):122-7.
    View in: PubMed
  35. Torchilin VP, Papisov MI, Smirnov VN. Magnetic Sephadex as a carrier for enzyme immobilization and drug targeting. J Biomed Mater Res. 1985 Apr; 19(4):461-6.
    View in: PubMed
  36. Papisov MI, Samokhin GP, Smirnov MD, Torcholin VP, Smirnov VN. [Possibilities of using ferromagnetic materials for targeted drug transport]. Biull Eksp Biol Med. 1984 Sep; 98(9):372-4.
    View in: PubMed
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