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Harald von Boehmer, Ph.D., M.D.

TitleProfessor of Microbiology and Immunobiology, Emeritus
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressDana Farber Cancer Institute
Smith Bldg, Rm 736
44 Binney St
Boston MA 02115
Phone617/632-6880
Fax617/632-6881

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kreslavsky T, Kim HJ, Koralov SB, Ghitza D, Buch T, Cantor H, Rajewsky K, von Boehmer H. Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. J Exp Med. 2013 Sep 23; 210(10):1911-8.
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  2. Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 2013 Jul 29; 210(8):1545-57.
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  3. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32.
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  4. von Boehmer H, Daniel C. Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer. Nat Rev Drug Discov. 2012 Dec 31; 12(1):51-63.
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  5. Gleimer M, von Boehmer H, Kreslavsky T. PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function. Front Immunol. 2012; 3:374.
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  6. Kreslavsky T, Gleimer M, Miyazaki M, Choi Y, Gagnon E, Murre C, Sicinski P, von Boehmer H. ß-Selection-Induced Proliferation Is Required for aß T Cell Differentiation. Immunity. 2012 Nov 16; 37(5):840-53.
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  7. Choi YJ, Li X, Hydbring P, Sanda T, Stefano J, Christie AL, Signoretti S, Look AT, Kung AL, von Boehmer H, Sicinski P. The requirement for cyclin d function in tumor maintenance. Cancer Cell. 2012 Oct 16; 22(4):438-51.
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  8. Schlenner SM, Weigmann B, Ruan Q, Chen Y, von Boehmer H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med. 2012 Aug 27; 209(9):1529-35.
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  9. Daniel C, von Boehmer H. Extra-thymically induced regulatory T cells: do they have potential in disease prevention? Semin Immunol. 2011 Dec; 23(6):410-7.
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  10. Daniel C, Weigmann B, Bronson R, von Boehmer H. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. J Exp Med. 2011 Jul 4; 208(7):1501-10.
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  11. Li X, Sanda T, Look AT, Novina CD, von Boehmer H. Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL. J Exp Med. 2011 Apr 11; 208(4):663-75.
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  12. Li X, von Boehmer H. Notch Signaling in T-Cell Development and T-ALL. ISRN Hematol. 2011; 2011:921706.
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  13. Daniel C, von Boehmer H. Extrathymic generation of regulatory T cells--chances and challenges for prevention of autoimmune disease. Adv Immunol. 2011; 112:177-213.
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  14. Daniel C, Ploegh H, von Boehmer H. Antigen-specific induction of regulatory T cells in vivo and in vitro. Methods Mol Biol. 2011; 707:173-85.
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  15. von Boehmer H, Waldmann H. Immunological tolerance. Front Immunol. 2010; 1:102.
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  16. Kreslavsky T, Gleimer M, Garbe AI, von Boehmer H. aß versus ?d fate choice: counting the T-cell lineages at the branch point. Immunol Rev. 2010 Nov; 238(1):169-81.
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  17. Stern JN, Keskin DB, Kato Z, Waldner H, Schallenberg S, Anderson A, von Boehmer H, Kretschmer K, Strominger JL. Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17280-5.
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  18. Daniel C, Wennhold K, Kim HJ, von Boehmer H. Enhancement of antigen-specific Treg vaccination in vivo. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16246-51.
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  19. Merkenschlager M, von Boehmer H. PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J Exp Med. 2010 Jul 5; 207(7):1347-50.
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  20. Kreslavsky T, von Boehmer H. gammadeltaTCR ligands and lineage commitment. Semin Immunol. 2010 Aug; 22(4):214-21.
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  21. Gleimer M, von Boehmer H. Thymocyte selection: chemokine signaling is not only about the destination. Curr Biol. 2010 Apr 13; 20(7):R316-8.
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  22. Feuerer M, Hill JA, Kretschmer K, von Boehmer H, Mathis D, Benoist C. Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):5919-24.
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  23. Kreslavsky T, Gleimer M, von Boehmer H. Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint. Curr Opin Immunol. 2010 Apr; 22(2):185-92.
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  24. von Boehmer H, Melchers F. Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol. 2010 Jan; 11(1):14-20.
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  25. Saran N, Lyszkiewicz M, Pommerencke J, Witzlau K, Vakilzadeh R, Ballmaier M, von Boehmer H, Krueger A. Multiple extrathymic precursors contribute to T-cell development with different kinetics. Blood. 2010 Feb 11; 115(6):1137-44.
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  26. Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, Strack PR, Winter CG, Winter SS, Larson RS, von Boehmer H, Look AT. Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood. 2010 Mar 4; 115(9):1735-45.
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  27. Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL. Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens. Diabetes. 2009 Dec; 58(12):2843-50.
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  28. Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med. 2009 Sep 28; 206(10):2131-9.
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  29. von Boehmer H. Central tolerance: essential for preventing autoimmune disease? Eur J Immunol. 2009 Sep; 39(9):2313-6.
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  30. Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12453-8.
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  31. Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem. 2009 Sep 11; 284(37):24914-24.
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  32. Daniel C, Nolting J, von Boehmer H. Mechanisms of self-nonself discrimination and possible clinical relevance. Immunotherapy. 2009 Jul; 1(4):631-44.
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  33. Saint-Ruf C, Ungewiss K, Groettrup M, Bruno L, Fehling HJ, von Boehmer H. Analysis and expression of a cloned pre-T cell receptor gene. Science. 1994. 266: 1208-1212. J Immunol. 2009 May 1; 182(9):5165-9.
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  34. von Boehmer H. Notch 1 keeps pro-T cells on track. Immunity. 2009 Jan 16; 30(1):5-7.
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  35. Li X, Gounari F, Protopopov A, Khazaie K, von Boehmer H. Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. J Exp Med. 2008 Nov 24; 205(12):2851-61.
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  36. Apostolou I, Verginis P, Kretschmer K, Polansky J, Hühn J, von Boehmer H. Peripherally induced Treg: mode, stability, and role in specific tolerance. J Clin Immunol. 2008 Nov; 28(6):619-24.
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  37. von Boehmer H. Positive and negative selection in Basel. Nat Immunol. 2008 Jun; 9(6):571-3.
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  38. Polansky JK, Kretschmer K, Freyer J, Floess S, Garbe A, Baron U, Olek S, Hamann A, von Boehmer H, Huehn J. DNA methylation controls Foxp3 gene expression. Eur J Immunol. 2008 Jun; 38(6):1654-63.
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  39. Rajewsky K, von Boehmer H. Lymphocyte development: overview. Curr Opin Immunol. 2008 Apr; 20(2):127-30.
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  40. Kreslavsky T, Garbe AI, Krueger A, von Boehmer H. T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis. J Exp Med. 2008 May 12; 205(5):1173-86.
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  41. Verginis P, McLaughlin KA, Wucherpfennig KW, von Boehmer H, Apostolou I. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A. 2008 Mar 4; 105(9):3479-84.
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  42. von Boehmer H, Nolting J. What turns on Foxp3? Nat Immunol. 2008 Feb; 9(2):121-2.
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  43. Egawa T, Kreslavsky T, Littman DR, von Boehmer H. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS One. 2008; 3(1):e1512.
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  44. Magnusson FC, Liblau RS, von Boehmer H, Pittet MJ, Lee JW, Turley SJ, Khazaie K. Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity. Gastroenterology. 2008 Apr; 134(4):1028-37.
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  45. Kretschmer K, Apostolou I, Verginis P, von Boehmer H. Regulatory T cells and antigen-specific tolerance. Chem Immunol Allergy. 2008; 94:8-15.
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  46. von Boehmer H. Oral tolerance: is it all retinoic acid? J Exp Med. 2007 Aug 6; 204(8):1737-9.
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  47. Bhandoola A, von Boehmer H, Petrie HT, Zúñiga-Pflücker JC. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity. 2007 Jun; 26(6):678-89.
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  48. Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A. p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis. Blood. 2007 Oct 1; 110(7):2610-9.
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  49. Guo Z, Dose M, Kovalovsky D, Chang R, O'Neil J, Look AT, von Boehmer H, Khazaie K, Gounari F. Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood. 2007 Jun 15; 109(12):5463-72.
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  50. Garbe AI, von Boehmer H. TCR and Notch synergize in alphabeta versus gammadelta lineage choice. Trends Immunol. 2007 Mar; 28(3):124-31.
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  51. Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 2007 Feb 22; 445(7130):931-5.
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  52. Krueger A, von Boehmer H. Identification of a T lineage-committed progenitor in adult blood. Immunity. 2007 Jan; 26(1):105-16.
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  53. von Boehmer H. Can studies of tolerance ever lead to therapy? Ann Rheum Dis. 2006 Nov; 65 Suppl 3:iii41-3.
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  54. Kretschmer K, Apostolou I, Jaeckel E, Khazaie K, von Boehmer H. Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer. Immunol Rev. 2006 Aug; 212:163-9.
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  55. Krueger A, Garbe AI, von Boehmer H. Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands. J Exp Med. 2006 Aug 7; 203(8):1977-84.
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  56. Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 2006 Jul; 25(1):129-41.
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  57. Ciofani M, Knowles GC, Wiest DL, von Boehmer H, Zúñiga-Pflücker JC. Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. Immunity. 2006 Jul; 25(1):105-16.
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  58. Dose M, Khan I, Guo Z, Kovalovsky D, Krueger A, von Boehmer H, Khazaie K, Gounari F. c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood. 2006 Oct 15; 108(8):2669-77.
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  59. Aifantis I, Bassing CH, Garbe AI, Sawai K, Alt FW, von Boehmer H. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med. 2006 Jun 12; 203(6):1543-50.
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  60. Garbe AI, Krueger A, Gounari F, Zúñiga-Pflücker JC, von Boehmer H. Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J Exp Med. 2006 Jun 12; 203(6):1579-90.
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  61. Grabher C, von Boehmer H, Look AT. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer. 2006 May; 6(5):347-59.
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  62. Scimone ML, Aifantis I, Apostolou I, von Boehmer H, von Andrian UH. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc Natl Acad Sci U S A. 2006 May 2; 103(18):7006-11.
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  63. von Boehmer H. Immunology. Thoracic thymus, exclusive no longer. Science. 2006 Apr 14; 312(5771):206-7.
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  64. Campese AF, Garbe AI, Zhang F, Grassi F, Screpanti I, von Boehmer H. Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. Blood. 2006 Jul 1; 108(1):305-10.
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  65. Jaeckel E, Kretschmer K, Apostolou I, von Boehmer H. Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity. Semin Immunol. 2006 Apr; 18(2):89-92.
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  66. von Boehmer H, Kisielow P. Negative selection of the T-cell repertoire: where and when does it occur? Immunol Rev. 2006 Feb; 209:284-9.
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  67. Khazaie K, von Boehmer H. The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer. Semin Cancer Biol. 2006 Apr; 16(2):124-36.
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  68. von Boehmer H. Shaping the T cell repertoire. J Immunol. 2006 Jan 1; 176(1):3-4.
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  69. Kretschmer K, Heng TS, von Boehmer H. De novo production of antigen-specific suppressor cells in vivo. Nat Protoc. 2006; 1(2):653-61.
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  70. von Boehmer H. Shaping the T cell repertoire. J Immunol. 2005 Dec 1; 175(11):7067-8.
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  71. Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, von Boehmer H, Mahnke K, Buer J. On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes. 2005 Dec; 54(12):3395-401.
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  72. Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol. 2005 Dec; 6(12):1219-27.
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  73. von Boehmer H. Peptide-based instruction of suppressor commitment in naïve T cells and dynamics of immunosuppression in vivo. Scand J Immunol. 2005 Jul; 62 Suppl 1:49-54.
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  74. von Boehmer H. Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. Nat Rev Immunol. 2005 Jul; 5(7):571-7.
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  75. von Boehmer H. Notch in lymphopoiesis and T cell polarization. Nat Immunol. 2005 Jul; 6(7):641-2.
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  76. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol. 2005 Apr; 6(4):338-44.
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  77. Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005 Feb 21; 201(4):603-14.
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  78. Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):419-24.
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  79. Jaeckel E, von Boehmer H, Manns MP. Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes. 2005 Feb; 54(2):306-10.
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  80. Jaeckel E, Lipes MA, von Boehmer H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol. 2004 Oct; 5(10):1028-35.
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  81. von Boehmer H. Type 1 diabetes: focus on prevention. Nat Med. 2004 Aug; 10(8):783-4.
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  82. von Boehmer H, Nussenzweig MC. The manipulation of immunity. Conference on from allergy to cancer: new perspectives for therapeutic vaccination. EMBO Rep. 2004 Aug; 5(8):765-70.
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  83. Apostolou I, von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med. 2004 May 17; 199(10):1401-8.
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  84. Borowski C, Li X, Aifantis I, Gounari F, von Boehmer H. Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development. J Exp Med. 2004 Mar 1; 199(5):607-15.
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  85. Bruder D, Probst-Kepper M, Westendorf AM, Geffers R, Beissert S, Loser K, von Boehmer H, Buer J, Hansen W. Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol. 2004 Mar; 34(3):623-30.
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  86. Apostolou I, Von Boehmer H. The TCR-HA, INS-HA transgenic model of autoimmune diabetes: limitations and expectations. J Autoimmun. 2004 Mar; 22(2):111-4.
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  87. von Boehmer H. Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development. Adv Immunol. 2004; 84:201-38.
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  88. Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003 Dec; 4(6):451-61.
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  89. Talora C, Campese AF, Bellavia D, Pascucci M, Checquolo S, Groppioni M, Frati L, von Boehmer H, Gulino A, Screpanti I. Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. EMBO Rep. 2003 Nov; 4(11):1067-72.
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  90. Apostolou I, Hao Z, Rajewsky K, von Boehmer H. Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med. 2003 Oct 6; 198(7):1103-6.
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  91. von Boehmer H. Dynamics of suppressor T cells: in vivo veritas. J Exp Med. 2003 Sep 15; 198(6):845-9.
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  92. Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep; 4(9):866-73.
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  93. Klein L, Khazaie K, von Boehmer H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8886-91.
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  94. Walter U, Toepfer T, Dittmar KE, Kretschmer K, Lauber J, Weiss S, Servos G, Lechner O, Scherbaum WA, Bornstein SR, Von Boehmer H, Buer J. Pancreatic NOD beta cells express MHC class II protein and the frequency of I-A(g7) mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes. Diabetologia. 2003 Aug; 46(8):1106-14.
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  95. Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med. 2003 Jun 16; 197(12):1635-44.
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  96. Haughn L, Hawley RG, Morrison DK, von Boehmer H, Hockenbery DM. BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation. J Biol Chem. 2003 Jul 4; 278(27):25158-65.
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  97. Klein L, Trautman L, Psarras S, Schnell S, Siermann A, Liblau R, von Boehmer H, Khazaie K. Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor. Eur J Immunol. 2003 Mar; 33(3):806-14.
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  98. von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, Apostolou I, Jaeckel E, Grassi F, Klein L. Thymic selection revisited: how essential is it? Immunol Rev. 2003 Feb; 191:62-78.
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  99. Ito Y, Arai S, van Oers NS, Aifantis I, von Boehmer H, Miyazaki T. Positive selection by the pre-TCR yields mature CD8+ T cells. J Immunol. 2002 Nov 1; 169(9):4913-9.
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  100. Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002 Nov 15; 298(5597):1395-401.
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  101. Apostolou I, Sarukhan A, Klein L, von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat Immunol. 2002 Aug; 3(8):756-63.
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  102. Panigada M, Porcellini S, Barbier E, Hoeflinger S, Cazenave PA, Gu H, Band H, von Boehmer H, Grassi F. Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med. 2002 Jun 17; 195(12):1585-97.
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  103. Gounari F, Signoretti S, Bronson R, Klein L, Sellers WR, Kum J, Siermann A, Taketo MM, von Boehmer H, Khazaie K. Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene. 2002 Jun 13; 21(26):4099-107.
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  104. Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol. 2002 May; 3(5):483-8.
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  105. Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol. 2002 May; 3(5):489-96.
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  106. Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, Grassi F, von Boehmer H. On the brink of becoming a T cell. Curr Opin Immunol. 2002 Apr; 14(2):200-6.
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  107. Bellavia D, Campese AF, Checquolo S, Balestri A, Biondi A, Cazzaniga G, Lendahl U, Fehling HJ, Hayday AC, Frati L, von Boehmer H, Gulino A, Screpanti I. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3788-93.
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  108. Casares S, Hurtado A, McEvoy RC, Sarukhan A, von Boehmer H, Brumeanu TD. Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide-MHC class II chimera. Nat Immunol. 2002 Apr; 3(4):383-91.
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  109. Lambolez F, Azogui O, Joret AM, Garcia C, von Boehmer H, Di Santo J, Ezine S, Rocha B. Characterization of T cell differentiation in the murine gut. J Exp Med. 2002 Feb 18; 195(4):437-49.
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  110. Miyoshi K, Shillingford JM, Le Provost F, Gounari F, Bronson R, von Boehmer H, Taketo MM, Cardiff RD, Hennighausen L, Khazaie K. Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A. 2002 Jan 8; 99(1):219-24.
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  111. von Boehmer H. Coming to grips with Notch. J Exp Med. 2001 Oct 1; 194(7):F43-6.
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  117. Dietz A, Ziegler CM, Dacho A, Althof F, Conradt C, Kolling G, von Boehmer H, Steffen H. Effectiveness of a new perforated 0.15 mm poly-p-dioxanon-foil versus titanium-dynamic mesh in reconstruction of the orbital floor. J Craniomaxillofac Surg. 2001 Apr; 29(2):82-8.
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  119. Sarukhan A, Camugli S, Gjata B, von Boehmer H, Danos O, Jooss K. Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors. J Virol. 2001 Jan; 75(1):269-77.
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  123. Walter U, Franzke A, Sarukhan A, Zober C, von Boehmer H, Buer J, Lechner O, Frantzke A. Monitoring gene expression of TNFR family members by beta-cells during development of autoimmune diabetes. Eur J Immunol. 2000 Apr; 30(4):1224-32.
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  124. Jordan MS, Riley MP, von Boehmer H, Caton AJ. Anergy and suppression regulate CD4(+) T cell responses to a self peptide. Eur J Immunol. 2000 Jan; 30(1):136-44.
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  125. Mancini S, Candéias SM, Fehling HJ, von Boehmer H, Jouvin-Marche E, Marche PN. TCR alpha-chain repertoire in pTalpha-deficient mice is diverse and developmentally regulated: implications for pre-TCR functions and TCRA gene rearrangement. J Immunol. 1999 Dec 1; 163(11):6053-9.
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  126. Aifantis I, Pivniouk VI, Gärtner F, Feinberg J, Swat W, Alt FW, von Boehmer H, Geha RS. Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein. J Exp Med. 1999 Oct 18; 190(8):1093-102.
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  127. Sarukhan A, Lechner O, von Boehmer H. Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells. Eur J Immunol. 1999 Oct; 29(10):3410-6.
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  128. Aifantis I, Feinberg J, Fehling HJ, Di Santo JP, von Boehmer H. Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex. J Exp Med. 1999 Jul 5; 190(1):141-4.
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  129. Eberl G, Fehling HJ, von Boehmer H, MacDonald HR. Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development. Eur J Immunol. 1999 Jun; 29(6):1966-71.
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  130. von Boehmer H, Sarukhan A. GAD, a single autoantigen for diabetes. Science. 1999 May 14; 284(5417):1135, 1137.
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  133. Grassi F, Barbier E, Porcellini S, von Boehmer H, Cazenave PA. Surface expression and functional competence of CD3-independent TCR zeta-chains in immature thymocytes. J Immunol. 1999 Mar 1; 162(5):2589-96.
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  136. Saint-Ruf C, Lechner O, Feinberg J, von Boehmer H. Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms. Eur J Immunol. 1998 Nov; 28(11):3824-31.
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  137. Aifantis I, Azogui O, Feinberg J, Saint-Ruf C, Buer J, von Boehmer H. On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment. Immunity. 1998 Nov; 9(5):649-55.
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  139. von Boehmer H, Kolling GH. [Effect of exposure time using single landolt-rings on visual acuity in normal individuals and patients with nystagmus]. Ophthalmologe. 1998 Oct; 95(10):717-20.
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  140. Bot A, Casares S, Bot S, von Boehmer H, Bona C. Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells. J Immunol. 1998 May 1; 160(9):4500-7.
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  141. Sarukhan A, Garcia C, Lanoue A, von Boehmer H. Allelic inclusion of T cell receptor alpha genes poses an autoimmune hazard due to low-level expression of autospecific receptors. Immunity. 1998 May; 8(5):563-70.
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  142. Buer J, Lanoue A, Franzke A, Garcia C, von Boehmer H, Sarukhan A. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J Exp Med. 1998 Jan 19; 187(2):177-83.
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  143. Sarukhan A, Lanoue A, Franzke A, Brousse N, Buer J, von Boehmer H. Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model. EMBO J. 1998 Jan 2; 17(1):71-80.
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  145. Kirberg J, Berns A, von Boehmer H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J Exp Med. 1997 Oct 20; 186(8):1269-75.
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  146. Krotkova A, von Boehmer H, Fehling HJ. Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene. J Exp Med. 1997 Aug 29; 186(5):767-75.
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  147. von Boehmer H. Lymphotoxins: from cytotoxicity to lymphoid organogenesis. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):8926-7.
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  148. Takase K, Wakizaka K, von Boehmer H, Wada I, Moriya H, Saito T. A new 12-kilodalton dimer associated with pre-TCR complex and clonotype-independent CD3 complex on immature thymocytes. J Immunol. 1997 Jul 15; 159(2):741-7.
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  151. Fehling HJ, Iritani BM, Krotkova A, Forbush KA, Laplace C, Perlmutter RM, von Boehmer H. Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha. Immunity. 1997 Jun; 6(6):703-14.
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  152. Buer J, Aifantis I, DiSanto JP, Fehling HJ, von Boehmer H. Role of different T cell receptors in the development of pre-T cells. J Exp Med. 1997 May 5; 185(9):1541-7.
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  153. von Boehmer H. T-call development: is notch a key player in lineage decisions? Curr Biol. 1997 May 1; 7(5):R308-10.
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  154. von Boehmer H, Burk RO, Holz FG. [Unilateral parapapillary accumulation of sub- and intraretinal fluid. Double-pitted optic papilla with parapapillary choroid neovascularization]. Ophthalmologe. 1997 May; 94(5):364-5.
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  156. von Boehmer H, Rajewsky K. Lymphocyte development essential features. Curr Opin Immunol. 1997 Apr; 9(2):213-5.
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  157. Lanoue A, Bona C, von Boehmer H, Sarukhan A. Conditions that induce tolerance in mature CD4+ T cells. J Exp Med. 1997 Feb 3; 185(3):405-14.
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  159. Collins C, Norris S, McEntee G, Traynor O, Bruno L, von Boehmer H, Hegarty J, O'Farrelly C. RAG1, RAG2 and pre-T cell receptor alpha chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation. Eur J Immunol. 1996 Dec; 26(12):3114-8.
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  160. Bruno L, von Boehmer H, Kirberg J. Cell division in the compartment of naive and memory T lymphocytes. Eur J Immunol. 1996 Dec; 26(12):3179-84.
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  161. Kronin V, Winkel K, Süss G, Kelso A, Heath W, Kirberg J, von Boehmer H, Shortman K. A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. J Immunol. 1996 Nov 1; 157(9):3819-27.
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  162. Bruno L, Fehling HJ, von Boehmer H. The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells. Immunity. 1996 Oct; 5(4):343-52.
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  163. Brumeanu TD, Casares S, Harris PE, Dehazya P, Wolf I, von Boehmer H, Bona CA. Immunopotency of a viral peptide assembled on the carbohydrate moieties of self immunoglobulins. Nat Biotechnol. 1996 Jun; 14(6):722-5.
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  164. Jacobs H, Ossendorp F, de Vries E, Ungewiss K, von Boehmer H, Borst J, Berns A. Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain. Oncogene. 1996 May 16; 12(10):2089-99.
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  165. von Boehmer H. CD4/CD8 lineage commitment: back to instruction? J Exp Med. 1996 Mar 1; 183(3):713-5.
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  166. Del Porto P, Bruno L, Mattei MG, von Boehmer H, Saint-Ruf C. Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12105-9.
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  167. van Oers NS, von Boehmer H, Weiss A. The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit. J Exp Med. 1995 Nov 1; 182(5):1585-90.
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  168. Von Boehmer H. Control of T-cell development by the pre-T and alpha beta T-cell receptor. Ann N Y Acad Sci. 1995 Sep 7; 766:52-61.
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  169. von Boehmer H. T cell differentiation: control by the pre-TCR and alpha beta TCR. Clin Immunol Immunopathol. 1995 Sep; 76(3 Pt 2):S145-50.
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  170. von Boehmer H. Immunogenetics. Female anti-male attack. Nature. 1995 Aug 24; 376(6542):642.
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  172. Fehling HJ, Krotkova A, Saint-Ruf C, von Boehmer H. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature. 1995 Jun 29; 375(6534):795-8.
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  173. Fehling HJ, Laplace C, Mattei MG, Saint-Ruf C, von Boehmer H. Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene. Immunogenetics. 1995; 42(4):275-81.
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  174. Kisielow P, von Boehmer H. Development and selection of T cells: facts and puzzles. Adv Immunol. 1995; 58:87-209.
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  175. Bruno L, Kirberg J, von Boehmer H. On the cellular basis of immunological T cell memory. Immunity. 1995 Jan; 2(1):37-43.
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  176. Degermann S, Reilly C, Scott B, Ogata L, von Boehmer H, Lo D. On the various manifestations of spontaneous autoimmune diabetes in rodent models. Eur J Immunol. 1994 Dec; 24(12):3155-60.
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  178. Fehling HJ, Swat W, Laplace C, Kühn R, Rajewsky K, Müller U, von Boehmer H. MHC class I expression in mice lacking the proteasome subunit LMP-7. Science. 1994 Aug 26; 265(5176):1234-7.
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  179. Baron A, Hafen K, von Boehmer H. A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice. Eur J Immunol. 1994 Aug; 24(8):1933-6.
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  180. Kirberg J, Baron A, Jakob S, Rolink A, Karjalainen K, von Boehmer H. Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med. 1994 Jul 1; 180(1):25-34.
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  181. Swat W, von Boehmer H, Kisielow P. Small CD4+8+TCRlow thymocytes contain precursors of mature T cells. Eur J Immunol. 1994 Apr; 24(4):1010-2.
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  182. Strasser A, Harris AW, von Boehmer H, Cory S. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1376-80.
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  183. Swat W, von Boehmer H, Kisielow P. Central tolerance: clonal deletion or clonal arrest? Eur J Immunol. 1994 Feb; 24(2):485-7.
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  184. von Boehmer H. Positive selection of lymphocytes. Cell. 1994 Jan 28; 76(2):219-28.
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  186. Groettrup M, Ungewiss K, Azogui O, Palacios R, Owen MJ, Hayday AC, von Boehmer H. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein. Cell. 1993 Oct 22; 75(2):283-94.
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  187. von Boehmer H, Swat W, Kisielow P. Positive selection of immature alpha beta T cells. Immunol Rev. 1993 Oct; 135:67-79.
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  188. Kelly KA, Pircher H, von Boehmer H, Davis MM, Scollay R. Regulation of T cell production in T cell receptor transgenic mice. Eur J Immunol. 1993 Aug; 23(8):1922-8.
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  189. Kirberg J, Bruno L, von Boehmer H. CD4+8- help prevents rapid deletion of CD8+ cells after a transient response to antigen. Eur J Immunol. 1993 Aug; 23(8):1963-7.
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  190. Groettrup M, von Boehmer H. T cell receptor beta chain dimers on immature thymocytes from normal mice. Eur J Immunol. 1993 Jun; 23(6):1393-6.
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  191. Rocha B, Tanchot C, Von Boehmer H. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J Exp Med. 1993 May 1; 177(5):1517-21.
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  196. Swat W, Dessing M, von Boehmer H, Kisielow P. CD69 expression during selection and maturation of CD4+8+ thymocytes. Eur J Immunol. 1993 Mar; 23(3):739-46.
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  197. Kirberg J, Swat W, Rocha B, Kisielow P, von Boehmer H. Induction of tolerance in immature and mature T cells. Transplant Proc. 1993 Feb; 25(1 Pt 1):279-80.
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  198. Lorès P, Boucher V, Mackay C, Pla M, Von Boehmer H, Jami J, Barré-Sinoussi F, Weill JC. Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection. AIDS Res Hum Retroviruses. 1992 Dec; 8(12):2063-71.
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  199. von Boehmer H. Thymic selection: a matter of life and death. Immunol Today. 1992 Nov; 13(11):454-8.
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  200. Swat W, Dessing M, Baron A, Kisielow P, von Boehmer H. Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes. Eur J Immunol. 1992 Sep; 22(9):2367-72.
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  201. Groettrup M, Baron A, Griffiths G, Palacios R, von Boehmer H. T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines. EMBO J. 1992 Jul; 11(7):2735-45.
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  202. Rocha B, von Boehmer H, Guy-Grand D. Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut. Proc Natl Acad Sci U S A. 1992 Jun 15; 89(12):5336-40.
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  203. Borgulya P, Kishi H, Uematsu Y, von Boehmer H. Exclusion and inclusion of alpha and beta T cell receptor alleles. Cell. 1992 May 1; 69(3):529-37.
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  204. Sidman CL, Marshall JD, Von Boehmer H. Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice. Eur J Immunol. 1992 Feb; 22(2):499-504.
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  206. von Boehmer H, Kirberg J, Rocha B. An unusual lineage of alpha/beta T cells that contains autoreactive cells. J Exp Med. 1991 Nov 1; 174(5):1001-8.
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  208. Huesmann M, Scott B, Kisielow P, von Boehmer H. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell. 1991 Aug 9; 66(3):533-40.
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  209. Kisielow P, Swat W, Rocha B, von Boehmer H. Induction of immunological unresponsiveness in vivo and in vitro by conventional and super-antigens in developing and mature T cells. Immunol Rev. 1991 Aug; 122:69-85.
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  210. Swat W, Ignatowicz L, von Boehmer H, Kisielow P. Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature. 1991 May 9; 351(6322):150-3.
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  211. Borgulya P, Kishi H, Müller U, Kirberg J, von Boehmer H. Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO J. 1991 Apr; 10(4):913-8.
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  213. Rocha B, von Boehmer H. Peripheral selection of the T cell repertoire. Science. 1991 Mar 8; 251(4998):1225-8.
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  214. Robey EA, Fowlkes BJ, Gordon JW, Kioussis D, von Boehmer H, Ramsdell F, Axel R. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell. 1991 Jan 11; 64(1):99-107.
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  216. Kishi H, Borgulya P, Scott B, Karjalainen K, Traunecker A, Kaufman J, von Boehmer H. Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. EMBO J. 1991 Jan; 10(1):93-100.
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  218. Jacobs H, Von Boehmer H, Melief CJ, Berns A. Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells. Eur J Immunol. 1990 Oct; 20(10):2333-7.
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  219. von Boehmer H, Kisielow P. Self-nonself discrimination by T cells. Science. 1990 Jun 15; 248(4961):1369-73.
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  220. Teh HS, Kishi H, Scott B, Borgulya P, von Boehmer H, Kisielow P. Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice. Dev Immunol. 1990; 1(1):1-10.
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  221. Van Ewijk W, Kisielow P, Von Boehmer H. Immunohistology of T cell differentiation in the thymus of H-Y-specific T cell receptor alpha/beta transgenic mice. Eur J Immunol. 1990 Jan; 20(1):129-37.
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  222. Kisielow P, von Boehmer H. Negative and positive selection of immature thymocytes: timing and the role of the ligand for alpha beta T cell receptor. Semin Immunol. 1990 Jan; 2(1):35-44.
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  224. von Boehmer H, Kisielow P, Kishi H, Scott B, Borgulya P, Teh HS. The expression of CD4 and CD8 accessory molecules on mature T cells is not random but correlates with the specificity of the alpha beta receptor for antigen. Immunol Rev. 1989 Jun; 109:143-51.
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  225. Scott B, Blüthmann H, Teh HS, von Boehmer H. The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens. Nature. 1989 Apr 13; 338(6216):591-3.
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  226. Teh HS, Kishi H, Scott B, Von Boehmer H. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J Exp Med. 1989 Mar 1; 169(3):795-806.
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  227. von Boehmer H, Teh HS, Kisielow P. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol Today. 1989 Feb; 10(2):57-61.
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  228. von Boehmer H, Kishi H, Borgulya P, Scott B, van Ewijk W, Teh HS, Kisielow P. Control of T-cell development by the TCR alpha beta for antigen. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:111-8.
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  229. von Boehmer H, Blüthmann H, Teh HS, Scott B. The utilization of the scid mutation in the study of T cell development. Curr Top Microbiol Immunol. 1989; 152:97-105.
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  230. von Boehmer H. Learning by the immune system studied in T-cell receptor transgenic mice. Thymus. 1989; 13(1-2):19-26.
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  231. von Boehmer H, Bonneville M, Ishida I, Ryser S, Lincoln G, Smith RT, Kishi H, Scott B, Kisielow P, Tonegawa S. Early expression of a T-cell receptor beta-chain transgene suppresses rearrangement of the V gamma 4 gene segment. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9729-32.
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  232. Kisielow P, Teh HS, Blüthmann H, von Boehmer H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature. 1988 Oct 20; 335(6192):730-3.
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  233. Teh HS, Kisielow P, Scott B, Kishi H, Uematsu Y, Blüthmann H, von Boehmer H. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature. 1988 Sep 15; 335(6187):229-33.
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  234. Blüthmann H, Kisielow P, Uematsu Y, Malissen M, Krimpenfort P, Berns A, von Boehmer H, Steinmetz M. T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes. Nature. 1988 Jul 14; 334(6178):156-9.
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  235. Kisielow P, Blüthmann H, Staerz UD, Steinmetz M, von Boehmer H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature. 1988 Jun 23; 333(6175):742-6.
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  236. Uematsu Y, Ryser S, Dembic Z, Borgulya P, Krimpenfort P, Berns A, von Boehmer H, Steinmetz M. In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell. 1988 Mar 25; 52(6):831-41.
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  237. Oestmann JW, Borcke E, von Boehmer H, Grote R, Hendrickx P, Majewski A, Mücke C, Stender HS. [Effect of observation time on the perception of details in x-ray pictures]. Rofo. 1988 Mar; 148(3):314-8.
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  238. Krimpenfort P, de Jong R, Uematsu Y, Dembic Z, Ryser S, von Boehmer H, Steinmetz M, Berns A. Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element. EMBO J. 1988 Mar; 7(3):745-50.
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  239. von Boehmer H, Kishi H, Uematsu Y, Teh HS, Scott B, Kisielow P. T cell repertoire selection in T cell receptor transgenic mice. Princess Takamatsu Symp. 1988; 19:107-13.
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  240. von Boehmer H, Karjalainen K, Pelkonen J, Borgulya P, Rammensee HG. The T-cell receptor for antigen in T-cell development and repertoire selection. Immunol Rev. 1988 Jan; 101:21-37.
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  241. von Boehmer H. The developmental biology of T lymphocytes. Annu Rev Immunol. 1988; 6:309-26.
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  242. von Boehmer H, Bluethmann H, Staerz U, Steinmetz M, Kisielow P. Developmental biology of T lymphocytes. Deletion of autoreactive T cells and impact of the alpha, beta receptor on the CD4/CD8 phenotype. Ann N Y Acad Sci. 1988; 546:104-8.
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  243. Palacios R, Kiefer M, Brockhaus M, Karjalainen K, Dembic Z, Kisielow P, von Boehmer H. Molecular, cellular, and functional properties of bone marrow T lymphocyte progenitor clones. J Exp Med. 1987 Jul 1; 166(1):12-32.
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  244. Dembic Z, Haas W, Zamoyska R, Parnes J, Steinmetz M, von Boehmer H. Transfection of the CD8 gene enhances T-cell recognition. Nature. 1987 Apr 2-8; 326(6112):510-1.
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  245. von Boehmer H, Fabel H. [Acute effect of air pollutants on the lung and respiratory tract of persons at-risk]. Prax Klin Pneumol. 1987 Apr; 41(4):108-17.
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  246. Oestmann JW, Wilken B, Gerhart F, Herrmann H, von Boehmer H, Majewski A. Left or right transaxillary approach in lower extremity arteriography for severe occlusive vascular disease. An anatomic study of a roentgenologic problem. Surg Radiol Anat. 1987; 9(4):315-7.
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  247. Palacios R, Sideras P, von Boehmer H. Recombinant interleukin 4/BSF-1 promotes growth and differentiation of intrathymic T cell precursors from fetal mice in vitro. EMBO J. 1987 Jan; 6(1):91-5.
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  248. Cristanti A, Colantoni A, Snodgrass R, von Boehmer H. Expression of T cell receptors by thymocytes: in situ staining and biochemical analysis. EMBO J. 1986 Nov; 5(11):2837-43.
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  249. von Boehmer H, Hafen K. Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells. Nature. 1986 Apr 17-23; 320(6063):626-8.
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  250. Dembic Z, Haas W, Weiss S, McCubrey J, Kiefer H, von Boehmer H, Steinmetz M. Transfer of specificity by murine alpha and beta T-cell receptor genes. Nature. 1986 Mar 20-26; 320(6059):232-8.
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  251. Palacios R, Von Boehmer H. Requirements for growth of immature thymocytes from fetal and adult mice in vitro. Eur J Immunol. 1986 Jan; 16(1):12-9.
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  252. von Boehmer H. Thymus development. Curr Top Microbiol Immunol. 1986; 126:19-25.
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  253. von Boehmer H, Haas W. Cytolytic T-cell clones and hybridomas. Methods Enzymol. 1986; 132:467-77.
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  254. Haas W, Mathur-Rochat J, Kisielow P, von Boehmer H. Cytolytic T cell hybridomas. III. The antigen specificity and the restriction specificity of cytolytic T cells do not phenotypically mix. Eur J Immunol. 1985 Sep; 15(9):963-5.
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  255. Snodgrass HR, Dembic Z, Steinmetz M, von Boehmer H. Expression of T-cell antigen receptor genes during fetal development in the thymus. Nature. 1985 May 16-22; 315(6016):232-3.
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  256. von Boehmer H, Crisanti A, Kisielow P, Haas W. Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2. Nature. 1985 Apr 11-17; 314(6011):539-40.
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  257. Snodgrass HR, Kisielow P, Kiefer M, Steinmetz M, von Boehmer H. Ontogeny of the T-cell antigen receptor within the thymus. Nature. 1985 Feb 14-20; 313(6003):592-5.
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  258. Kisielow P, Krammer PH, Hültner L, von Boehmer H. Maturation of fetal thymocytes in organ culture: secretion of interleukin 2, interferon and colony stimulating factors. Thymus. 1985; 7(3):189-98.
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  259. Von Boehmer H, Schubiger K. Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells. Eur J Immunol. 1984 Nov; 14(11):1048-52.
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  260. Haas W, Mathur-Rochat J, Pohlit H, Von Boehmer H. Cytotoxic T cell responses to haptenated cells. IV. Requirements for in vivo priming. Eur J Immunol. 1984 Nov; 14(11):1069-72.
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  261. Kisielow P, Leiserson W, Von Boehmer H. Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells. J Immunol. 1984 Sep; 133(3):1117-23.
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  262. von Boehmer H, Kisielow P, Leiserson W, Haas W. Lyt-2- T cell-independent functions of Lyt-2+ cells stimulated with antigen or concanavalin A. J Immunol. 1984 Jul; 133(1):59-64.
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  263. Haas W, von Boehmer H. Surface markers of cytotoxic T lymphocyte clones. Eur J Immunol. 1984 Apr; 14(4):383-4.
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  264. von Boehmer H, Kisielow P. Helper cell-independent clonal expansion of H-2D-restricted cytolytic T cells. Fed Proc. 1984 Feb; 43(2):268-70.
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  265. Hausmann E, Kohl B, von Boehmer H, Wellhöner HH. False-positive EMIT indication of opiates and methadone in a doxylamine intoxication. J Clin Chem Clin Biochem. 1983 Oct; 21(10):599-600.
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  266. von Boehmer H, Bennink J, Teh HS, Haas W. Selection of the T-cell repertoire during ontogeny. Ann Immunol (Paris). 1983 Jul-Aug; 134D(1):17-24.
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  267. von Boehmer H. Ontogenic aspects of the syngeneic mixed leukocyte reaction. Behring Inst Mitt. 1983 May; (72):3-6.
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  268. Teh HS, Romaniuk R, Von Boehmer H. H-2D products do not affect lysis of Kk target cells by Kk-specific cytotoxic T cells. Eur J Immunol. 1983 Mar; 13(3):259-61.
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  269. Von Boehmer H, Turton K. Autonomously proliferating K/D-restricted cytolytic T cell clones. Eur J Immunol. 1983 Feb; 13(2):176-9.
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  270. Teh HS, Bennink J, Von Boehmer H. Selection of the T cell repertoire during ontogeny: limiting dilution analysis. Eur J Immunol. 1982 Oct; 12(10):887-92.
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  271. Von Boehmer H, Bennink J, Langhorne J. The frequency of mutant-specific killer precursors in related and unrelated mouse strains. Eur J Immunol. 1982 Oct; 12(10):892-5.
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  272. Haas W, Von Boehmer H. Methods for the establishment of continuously growing cytolytic T cell clones. J Immunol Methods. 1982 Jul 30; 52(2):137-48.
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  273. Kisielow P, Von Boehmer H, Haas W. Functional and phenotypic properties of subpopulations of murine thymocytes. I. The bulk of peanut agglutinin-positive Lyt-1,2,3 thymocytes lacks precursors of cytotoxic T lymphocytes responsive to interleukin 2 (T cell growth factor). Eur J Immunol. 1982 Jun; 12(6):463-7.
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  274. Julius MH, von Boehmer H, Sidman CL. Dissociation of two signals required for activation of resting B cells. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):1989-93.
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  275. Günther J, Haas W, Von Boehmer H. Suppression of T cell responses through competition for T cell growth factor (interleukin 2). Eur J Immunol. 1982 Mar; 12(3):247-9.
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  276. von Boehmer H. Immune response regulation. Adv Exp Med Biol. 1982; 149:733-6.
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  277. Kurosawa Y, von Boehmer H, Haas W, Sakano H, Trauneker A, Tonegawa S. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes. Nature. 1981 Apr 16; 290(5807):565-70.
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  278. Martinez-Alonso C, Coutinho A, von Boehmer H, Bernabé R. Hapten-specific helper T cells III. Fine specificity of the (4-hydroxy-3-nitro-phenyl)acetyl (NP)-specific response in Igh-1b mice. Eur J Immunol. 1981 Mar; 11(3):172-4.
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  279. von Boehmer H, Haas W. H-2 restricted cytolytic and noncytolytic T cell clones: isolation, specificity and functional analysis. Immunol Rev. 1981; 54:27-56.
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  280. Haas W, Mathur-Rochat J, Pohlit H, Nabholz M, von Boehmer H. Cytotoxic T cell responses to haptenated cells. III. Isolation and specificity analysis of continuously growing clones. Eur J Immunol. 1980 Nov; 10(11):828-34.
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  281. Nabholz M, Cianfriglia M, Acuto O, Conzelmann A, Haas W, von Boehmer H, McDonald HR, Pohlit H, Johnson JP. Cytolytically active murine T-cell hybrids. Nature. 1980 Oct 2; 287(5781):437-40.
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  282. Engers HD, Collavo D, North M, von Boehmer H, Haas W, Hengartner H, Nabholz M. Characterization of cloned murine cytolytic T cell lines. J Immunol. 1980 Oct; 125(4):1481-6.
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  283. von Boehmer H, Haas W, Pohlit H, Hengartner H, Nabholz M. T cell clones: their use for the study of specificity, induction, and effector-function of T cells. Springer Semin Immunopathol. 1980 May; 3(1):23-37.
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  284. Schreier MH, Iscove NN, Tees R, Aarden L, von Boehmer H. Clones of killer and helper T cells: growth requirements, specificity and retention of function in long-term culture. Immunol Rev. 1980; 51:315-36.
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  285. Nabholz M, Conzelmann A, Acuto O, North M, Haas W, Pohlit H, von Boehmer H, Hengartner H, Mach JP, Engers H, Johnson JP. Established murine cytolytic T-cell lines as tools for a somatic cell genetic analysis of T-cell functions. Immunol Rev. 1980; 51:125-56.
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  286. von Boehmer H, Haas W. Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen. J Exp Med. 1979 Nov 1; 150(5):1134-42.
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  287. von Boehmer H, Turton K, Haas W. The role of the left end of the H-2b haplotype in the male-specific cytotoxic T cell response. Eur J Immunol. 1979 Nov; 9(11):913-5.
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  288. Pohlit H, Haas W, von Boehmer H. Cytotoxic T cell responses to haptenated cells. I. Primary, secondary and long-term cultures. Eur J Immunol. 1979 Sep; 9(9):681-90.
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  289. von Boehmer H, Hengartner H, Nabholz M, Lernhardt W, Schreier MH, Haas W. Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur J Immunol. 1979 Aug; 9(8):592-7.
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  290. Sprent J, von Boehmer H. T-helper function of parent leads to F1 chimeras. Presence of a separate T-cell subgroup able to stimulate allogeneic B cells but not syngeneic B cells. J Exp Med. 1979 Feb 1; 149(2):387-97.
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  291. Erb P, Meier B, Kraus D, von Boehmer H, Feldmann M. Nature of T cell-macrophage interaction in helper cell induction in vitro. I. Evidence for genetic restriction of T cell-macrophage interactions prior to T cell priming. Eur J Immunol. 1978 Nov; 8(11):786-92.
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  292. von Boehmer H, Haas W, Jerne NK. Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice. Proc Natl Acad Sci U S A. 1978 May; 75(5):2439-42.
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  293. von Boehmer H, Haas W, Pohlit H. Cytotoxic T cells recognize male antigen and H-2 as distinct entities. J Exp Med. 1978 Apr 1; 147(4):1291-5.
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  294. Haas W, von Boehmer H. Techniques for separation and selection of antigen specific lymphocytes. Curr Top Microbiol Immunol. 1978; 84:1-120.
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  295. Shortman K, Ryden A, Dunkley M, Von Boehmer H. Some requirements for the response of separated T-cell sub-populations to the mitogens phytohaemagglutinin and concanavalin A. Aust J Exp Biol Med Sci. 1977 Oct; 55(5):585-603.
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  296. von Boehmer H, Fathman CG, Haas W. H-2 gene complementation in cytotoxic T cell responses of female against male cells. Eur J Immunol. 1977 Jul; 7(7):443-7.
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  297. von Boehmer H, Sprent J, Haas W. The influence of H-2 gene products on cell-mediated and humoral immune responses. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 2:539-45.
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  298. von Boehmer H, Sprent J, Nabholz M. Hemopoietic reconstitution obtained in F1 hybrids by grafting of parental marrow cells. Transplant Proc. 1976 Sep; 8(3):355-8.
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  299. Sprent J, von Boehmer H. Helper function of T cells depleted of alloantigen-reactive lymphocytes by filtration through irradiated F1 hybrid recipients. I. Failure to collaborate with allogeneic B cells in a secondary response to sheep erythrocytes measured in vivo. J Exp Med. 1976 Sep 1; 144(3):617-26.
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  300. Melchers F, Cone RE, von Boehmer H, Sprent J. Immunoglobulin turnover in B lymphocyte subpopulations. Eur J Immunol. 1976 Jun; 5(6):382-8.
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  301. Von Boehmer H, Haas W. Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells. Nature. 1976 May 13; 261(5556):141-2.
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  302. Sprent J, von Boehmer H. Activation of T lymphocytes to M locus determinants in vivo. I. Quantitation of T cell proliferation and migration into thoracic duct lymph. Eur J Immunol. 1976 May; 6(5):352-8.
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  303. Krammer PH, Elliott BE, von Boehmer H. Fc-rosetting and nonrosetting T cells are killer cells. Eur J Immunol. 1976 Feb; 6(2):138-9.
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  304. Shortman K, Fidler JM, Schlegel RA, Nossal GJ, Howard M, Lipp J, von Boehmer H. Subpopulations of B lymphocytes: physical separation of functionally distinct stages of B-cell differentiation. Contemp Top Immunobiol. 1976; 5:1-45.
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  305. von Boehmer H, Sprent J. T cell function in bone marrow chimeras: absence of host-reactive T cells and cooperation of helper T cells across allogeneic barriers. Transplant Rev. 1976; 29:3-23.
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  306. von Boehmer H, Hudson L, Sprent J. Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras. J Exp Med. 1975 Oct 1; 142(4):989-97.
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  307. von Boehmer H, Shortman K. The differentiation of T lymphocytes. Density characterisation of thymic and peripheral T cells responding in syngeneic and allogenic mixed lymphocyte reactions. Aust J Exp Biol Med Sci. 1975 Aug; 53(4):281-95.
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  308. Osmond DG, Miller RG, von Boehmer H. Characterization of immunoglobulin-bearing and other small lymphocytes in mouse bone marrow by sedimentation and electrophoresis. J Immunol. 1975 Apr; 114(4):1230-6.
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  309. Schlegel RA, von Boehmer H, Shortman K. Antigen-initiated B lymphocyte differentiation. V. Electrophoretic separation of different subpopulations of AFC progenitors for unprimed IgM and memory IgG responses to the NIP determinant. Cell Immunol. 1975 Mar; 16(1):203-17.
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  310. Roelants GE, Loor F, von Boehmer H, Sprent J, Hägg LB, Mayor KS, Rydén A. Five types of lymphocytes (Ig-theta-, Ig-theta+weak, Ig-theta+strong, Ig+theta- and Ig+theta+) characterized by double immunofluorescence and electrophoretic mobility. Organ distribution in normal and nude mice. Eur J Immunol. 1975 Feb; 5(2):127-31.
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  311. Melchers F, Von Boehmer H, Phillips RA. B-lymphocyte subpopulations in the mouse. Organ distribution and ontogeny of immunoglobulin-synthesizing and of mitogen-sensitive cells. Transplant Rev. 1975; 25:26-58.
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  312. Shortman K, Von Boehmer H, Lipp J, Hopper K. Subpopulations of T-lymphocytes. Physical separation, functional specialisation and differentiation pathways of sub-sets of thymocytes and thymus-dependent peripheral lymphocytes. Transplant Rev. 1975; 25:163-210.
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  313. von Boehmer H, Lehmann-Grube F, Flemer R, Heuwinkel R. Multiplication of lymphocytic choriomeningitis virus in cultivated foetal inbred mouse cells and in neonatally infected inbred carrier mice. J Gen Virol. 1974 Nov; 25(2):219-28.
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  314. von Boehmer H, Sprent J. Expression of M locus differences by B cells but not T cells. Nature. 1974 May 24; 249(455):363-5.
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  315. Von Boehmer H. Selective stimulation by B lymphocytes in the syngeneic mixed lymphocyte reaction. Eur J Immunol. 1974 Feb; 4(2):105-10.
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  316. von Boehmer H, Shortman K. The separation of different cell classes from lymphoid organs. IX. A simple and rapid method for removal of damaged cells from lymphoid cell suspensions. J Immunol Methods. 1973 Apr; 2(3):293-301.
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  317. von Boehmer H. Direct cell contact is required in the syngeneic mixed lymphocyte reaction. Eur J Immunol. 1973 Feb; 3(2):109-11.
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  318. Von Boehmer H, Adams PB. Syngeneic mixed lymphocyte reaction between thymocytes and peripheral lymphoid cells in mice: strain specificity and nature of the target cell. J Immunol. 1973 Feb; 110(2):376-83.
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  319. Byrd WJ, Von Boehmer H, Rouse BT. The role of the thymus in maturational development of phytohemagglutinin and pokeweed mitogen responsiveness. Cell Immunol. 1973 Jan; 6(1):12-24.
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  320. von Boehmer H, Byrd WJ. Stimulation of mouse thymocytes by syngeneic spleen cells in mixed lymphocyte reactions. Adv Exp Med Biol. 1973; 29(0):217-23.
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  321. Von Boehmer H, Shortman K, Adams P. Nature of the stimulating cell in the syngeneic and the allogeneic mixed lymphocyte reaction in mice. J Exp Med. 1972 Dec 1; 136(6):1648-60.
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  322. von Boehmer H, Bayer R. [Experiments on rats for finding out the immune response to a Yoshida hepatoma ascites transplant]. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1972; 77(1):45-56.
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  323. Bayer R, von Boehmer H. [Cold-antibodies in rat serum against Yoshida-hepatom ascites cells]. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1972; 77(1):40-4.
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  324. von Boehmer H, Bayer R, Gladigau V, Ruhenstroth-Bauer G. [Relation between the cytotoxic and electrokinetic effect of human serum on L cells and Yoshida hepatoma ascites cells]. Z Naturforsch B. 1970 Feb; 25(2):205-12.
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  325. von Boehmer H, Gladigau V, Bayer R, Ruhenstroth-Bauer G. [Binding of a fraction from human Ig-G-globulin to the membrane of L cells, Zajdela and Yoshida ascites cells]. Z Naturforsch B. 1969 Aug; 24(8):1026-31.
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  326. Arnold R, von Boehmer H, Ruhenstroth-Bauer G. [On the effect of factors from human serum on the electrophoretic mobility of mammalian cells]. Exp Cell Res. 1968 Jun; 50(3):562-80.
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