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Last Name
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Donald Mark Coen, Ph.D.

TitleProfessor of Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
AddressHarvard Medical School
SGMB-304
250 Longwood Ave
Boston MA 02115
Phone617/432-1691
Fax617/432-3833

 Mentoring 
 current student opportunities
Available: 09/09/13, Expires: 09/08/14

Our laboratory takes multidisciplinary approaches to herpesvirus replication and latency. Because herpesviruses such as herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are important pathogens, we seek to exploit differences between herpesvirus and cellular processes for safe and effective antiviral therapy. Research projects could include investigations of the roles of microRNAs during productive and latent infections, testing the importance of potential drug targets for viral replication, screening for new antiviral compounds, and analysis of mechanisms of resistance to current antiviral drugs.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sharma M, Kamil JP, Coughlin M, Reim NI, Coen DM. Human Cytomegalovirus UL50 and UL53 Recruit Viral Protein Kinase UL97, Not Protein Kinase C, for Disruption of Nuclear Lamina and Nuclear Egress in Infected Cells. J Virol. 2014 Jan; 88(1):249-62.
    View in: PubMed
  2. Pan D, Kaye SB, Hopkins M, Kirwan R, Hart IJ, Coen DM. Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient. J Infect Dis. 2014 Feb; 209(3):345-9.
    View in: PubMed
  3. Reim NI, Kamil JP, Wang D, Lin A, Sharma M, Ericsson M, Pesola JM, Golan DE, Coen DM. Inactivation of Retinoblastoma Protein Does Not Overcome the Requirement for Human Cytomegalovirus UL97 in Lamina Disruption and Nuclear Egress. J Virol. 2013 May; 87(9):5019-27.
    View in: PubMed
  4. Cliffe AR, Coen DM, Knipe DM. Kinetics of Facultative Heterochromatin and Polycomb Group Protein Association with the Herpes Simplex Viral Genome during Establishment of Latent Infection. MBio. 2013; 4(1).
    View in: PubMed
  5. Weller SK, Coen DM. Herpes simplex viruses: mechanisms of DNA replication. Cold Spring Harb Perspect Biol. 2012 Sep; 4(9):a013011.
    View in: PubMed
  6. Pan D, Coen DM. Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):14852-7.
    View in: PubMed
  7. Terrell SL, Coen DM. The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication. J Virol. 2012 Oct; 86(20):11057-65.
    View in: PubMed
  8. Strang BL, Bender BJ, Sharma M, Pesola JM, Sanders RL, Spector DH, Coen DM. A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization. J Virol. 2012 Oct; 86(20):11066-77.
    View in: PubMed
  9. Jurak I, Silverstein LB, Sharma M, Coen DM. Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity. J Virol. 2012 Sep; 86(18):10093-102.
    View in: PubMed
  10. Strang BL, Boulant S, Kirchhausen T, Coen DM. Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. MBio. 2012; 3(1).
    View in: PubMed
  11. Pan D, Coen DM. Quantification and analysis of thymidine kinase expression from acyclovir-resistant G-string insertion and deletion mutants in herpes simplex virus-infected cells. J Virol. 2012 Apr; 86(8):4518-26.
    View in: PubMed
  12. Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95.
    View in: PubMed
  13. Coen DM, Whitley RJ. Antiviral drugs and antiviral drug resistance. Curr Opin Virol. 2011 Dec; 1(6):545-7.
    View in: PubMed
  14. Kramer MF, Jurak I, Pesola JM, Boissel S, Knipe DM, Coen DM. Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia. Virology. 2011 Sep 1; 417(2):239-47.
    View in: PubMed
  15. Silva LA, Strang BL, Lin EW, Kamil JP, Coen DM. Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44. Virology. 2011 Sep 1; 417(2):268-80.
    View in: PubMed
  16. Jurak I, Griffiths A, Coen DM. Mammalian alphaherpesvirus miRNAs. Biochim Biophys Acta. 2011 Nov-Dec; 1809(11-12):641-53.
    View in: PubMed
  17. Kamil JP, Coen DM. HATs on for drug resistance. Cell Host Microbe. 2011 Feb 17; 9(2):85-7.
    View in: PubMed
  18. Silva LA, Loregian A, Pari GS, Strang BL, Coen DM. The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication. J Virol. 2010 Nov; 84(21):11563-8.
    View in: PubMed
  19. Tran K, Kamil JP, Coen DM, Spector DH. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. J Virol. 2010 Oct; 84(20):10832-43.
    View in: PubMed
  20. Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC. Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir. Antimicrob Agents Chemother. 2010 Aug; 54(8):3093-8.
    View in: PubMed
  21. Strang BL, Geballe AP, Coen DM. Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44. J Gen Virol. 2010 Sep; 91(Pt 9):2167-75.
    View in: PubMed
  22. Coen D. Priscilla Schaffer (1941-2009): a stalwart herpesvirologist. J Virol. 2010 Jul; 84(13):6265-7.
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  23. Strang BL, Coen DM. Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54. J Gen Virol. 2010 Aug; 91(Pt 8):2029-33.
    View in: PubMed
  24. Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM. Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2. J Virol. 2010 May; 84(9):4659-72.
    View in: PubMed
  25. Strang BL, Boulant S, Coen DM. Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. J Virol. 2010 Feb; 84(4):1771-84.
    View in: PubMed
  26. Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM. The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. J Virol. 2009 Dec; 83(23):12215-28.
    View in: PubMed
  27. Kamil JP, Hume AJ, Jurak I, Münger K, Kalejta RF, Coen DM. Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16823-8.
    View in: PubMed
  28. Jiang C, Komazin-Meredith G, Tian W, Coen DM, Hwang CB. Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity. J Virol. 2009 Aug; 83(15):7573-80.
    View in: PubMed
  29. Strang BL, Sinigalia E, Silva LA, Coen DM, Loregian A. Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84. J Virol. 2009 Aug; 83(15):7581-9.
    View in: PubMed
  30. Hamirally S, Kamil JP, Ndassa-Colday YM, Lin AJ, Jahng WJ, Baek MC, Noton S, Silva LA, Simpson-Holley M, Knipe DM, Golan DE, Marto JA, Coen DM. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. PLoS Pathog. 2009 Jan; 5(1):e1000275.
    View in: PubMed
  31. Sam MD, Evans BT, Coen DM, Hogle JM. Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex. J Virol. 2009 Apr; 83(7):2996-3006.
    View in: PubMed
  32. Sinigalia E, Alvisi G, Mercorelli B, Coen DM, Pari GS, Jans DA, Ripalti A, Palù G, Loregian A. Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells. J Virol. 2008 Dec; 82(24):12574-9.
    View in: PubMed
  33. Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30; 379(2):197-204.
    View in: PubMed
  34. Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM. The human cytomegalovirus UL44 C clamp wraps around DNA. Structure. 2008 Aug 6; 16(8):1214-25.
    View in: PubMed
  35. Komazin-Meredith G, Mirchev R, Golan DE, van Oijen AM, Coen DM. Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31):10721-6.
    View in: PubMed
  36. Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, Cullen BR. MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature. 2008 Aug 7; 454(7205):780-3.
    View in: PubMed
  37. Hume AJ, Finkel JS, Kamil JP, Coen DM, Culbertson MR, Kalejta RF. Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science. 2008 May 9; 320(5877):797-9.
    View in: PubMed
  38. Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM. The positively charged surface of herpes simplex virus UL42 mediates DNA binding. J Biol Chem. 2008 Mar 7; 283(10):6154-61.
    View in: PubMed
  39. Bryant KF, Coen DM. Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript. J Virol. 2008 Jan; 82(1):77-85.
    View in: PubMed
  40. Jiang C, Hwang YT, Wang G, Randell JC, Coen DM, Hwang CB. Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis. J Virol. 2007 Nov; 81(21):12077-9.
    View in: PubMed
  41. Kamil JP, Coen DM. Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65. J Virol. 2007 Oct; 81(19):10659-68.
    View in: PubMed
  42. Loregian A, Sinigalia E, Mercorelli B, Palù G, Coen DM. Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism. Nucleic Acids Res. 2007; 35(14):4779-91.
    View in: PubMed
  43. Dodson AW, Taylor TJ, Knipe DM, Coen DM. Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach. Virology. 2007 Sep 30; 366(2):340-8.
    View in: PubMed
  44. Besecker MI, Furness CL, Coen DM, Griffiths A. Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia. J Virol. 2007 Aug; 81(15):8356-60.
    View in: PubMed
  45. Pesola JM, Coen DM. In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant. J Gen Virol. 2007 May; 88(Pt 5):1410-4.
    View in: PubMed
  46. Jiang C, Hwang YT, Randell JC, Coen DM, Hwang CB. Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication. J Virol. 2007 Apr; 81(7):3495-502.
    View in: PubMed
  47. Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Cytom. 2006 Aug; Appendix 3:Appendix 3K.
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  48. Griffiths A, Link MA, Furness CL, Coen DM. Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase. J Virol. 2006 Jul; 80(13):6568-74.
    View in: PubMed
  49. Cui C, Griffiths A, Li G, Silva LM, Kramer MF, Gaasterland T, Wang XJ, Coen DM. Prediction and identification of herpes simplex virus 1-encoded microRNAs. J Virol. 2006 Jun; 80(11):5499-508.
    View in: PubMed
  50. Shogan B, Kruse L, Mulamba GB, Hu A, Coen DM. Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B. J Virol. 2006 May; 80(10):4740-7.
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  51. Loregian A, Coen DM. Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Chem Biol. 2006 Feb; 13(2):191-200.
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  52. Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM. Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. J Biol Chem. 2006 Feb 24; 281(8):5224-32.
    View in: PubMed
  53. Pesola JM, Zhu J, Knipe DM, Coen DM. Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. J Virol. 2005 Dec; 79(23):14516-25.
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  54. Wang QY, Zhou C, Johnson KE, Colgrove RC, Coen DM, Knipe DM. Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection. Proc Natl Acad Sci U S A. 2005 Nov 1; 102(44):16055-9.
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  55. Bryant KF, Cox JC, Wang H, Hogle JM, Ellington AD, Coen DM. Binding of herpes simplex virus-1 US11 to specific RNA sequences. Nucleic Acids Res. 2005; 33(19):6090-100.
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  56. Randell JC, Komazin G, Jiang C, Hwang CB, Coen DM. Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis. J Virol. 2005 Sep; 79(18):12025-34.
    View in: PubMed
  57. Griffiths A, Coen DM. An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci U S A. 2005 Jul 5; 102(27):9667-72.
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  58. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005 Feb 11; 307(5711):935-9.
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  59. Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA, Coen DM, Knipe DM. Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Virol J. 2004; 1:5.
    View in: PubMed
  60. Loregian A, Appleton BA, Hogle JM, Coen DM. Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit. J Virol. 2004 Sep; 78(17):9084-92.
    View in: PubMed
  61. Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM. The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Mol Cell. 2004 Jul 23; 15(2):233-44.
    View in: PubMed
  62. Baek MC, Krosky PM, Pearson A, Coen DM. Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase. Virology. 2004 Jun 20; 324(1):184-93.
    View in: PubMed
  63. Pilger BD, Cui C, Coen DM. Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication. Chem Biol. 2004 May; 11(5):647-54.
    View in: PubMed
  64. Randell JC, Coen DM. The herpes simplex virus processivity factor, UL42, binds DNA as a monomer. J Mol Biol. 2004 Jan 9; 335(2):409-13.
    View in: PubMed
  65. Loregian A, Appleton BA, Hogle JM, Coen DM. Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44. J Virol. 2004 Jan; 78(1):158-67.
    View in: PubMed
  66. Pearson A, Knipe DM, Coen DM. ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells. J Virol. 2004 Jan; 78(1):23-32.
    View in: PubMed
  67. Chen SH, Pearson A, Coen DM, Chen SH. Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment. J Virol. 2004 Jan; 78(1):520-3.
    View in: PubMed
  68. Kramer MF, Cook WJ, Roth FP, Zhu J, Holman H, Knipe DM, Coen DM. Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression. J Virol. 2003 Sep; 77(17):9533-41.
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  69. Krosky PM, Baek MC, Jahng WJ, Barrera I, Harvey RJ, Biron KK, Coen DM, Sethna PB. The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase. J Virol. 2003 Jul; 77(14):7720-7.
    View in: PubMed
  70. Coen DM, Schaffer PA. Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets. Nat Rev Drug Discov. 2003 Apr; 2(4):278-88.
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  71. Griffiths A, Chen SH, Horsburgh BC, Coen DM. Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency. J Virol. 2003 Apr; 77(8):4703-9.
    View in: PubMed
  72. Kramer M, Riley J, Spoering A, Coen D, Knipe D. Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion. Curr Eye Res. 2003 Mar-Apr; 26(3-4):185-94.
    View in: PubMed
  73. Griffiths A, Coen DM. High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant. J Virol. 2003 Feb; 77(3):2282-6.
    View in: PubMed
  74. Krosky PM, Baek MC, Coen DM. The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress. J Virol. 2003 Jan; 77(2):905-14.
    View in: PubMed
  75. Baek MC, Krosky PM, Coen DM. Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase. J Virol. 2002 Dec; 76(23):11943-52.
    View in: PubMed
  76. Pearson A, Coen DM. Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1. J Virol. 2002 Nov; 76(21):10821-8.
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  77. Kramer MF, Coen DM. The polymerase chain reaction. Curr Protoc Protein Sci. 2002 Nov; Appendix 4:Appendix 4J.
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  78. Baek MC, Krosky PM, He Z, Coen DM. Specific phosphorylation of exogenous protein and peptide substrates by the human cytomegalovirus UL97 protein kinase. Importance of the P+5 position. J Biol Chem. 2002 Aug 16; 277(33):29593-9.
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  79. Chen SH, Lee LY, Garber DA, Schaffer PA, Knipe DM, Coen DM. Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus. J Virol. 2002 May; 76(10):4764-72.
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  80. Coen DM. Quantitation of rare DNAs by PCR. Curr Protoc Mol Biol. 2001 Nov; Chapter 15:Unit 15.7.
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  81. Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Mol Biol. 2001 Nov; Chapter 15:Unit 15.1.
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  82. Randell JC, Coen DM. Linear diffusion on DNA despite high-affinity binding by a DNA polymerase processivity factor. Mol Cell. 2001 Oct; 8(4):911-20.
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  83. Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Pharmacol. 2001 Aug; Chapter 6:Unit6.7.
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  84. Bridges KG, Chow CS, Coen DM. Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches. J Virol. 2001 Jun; 75(11):4990-8.
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  85. Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Toxicol. 2001 May; Appendix 3:A.3C.1-14.
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  86. Coen DM. Quantitation of rare DNAs by PCR. Curr Protoc Immunol. 2001 May; Chapter 10:Unit 10.21.
    View in: PubMed
  87. Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Cell Biol. 2001 May; Appendix 3:Appendix 3F.
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  88. Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Immunol. 2001 May; Chapter 10:Unit 10.20.
    View in: PubMed
  89. Burkham J, Coen DM, Hwang CB, Weller SK. Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments. J Virol. 2001 Mar; 75(5):2353-67.
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  90. Chen SH, Garber DA, Schaffer PA, Knipe DM, Coen DM. Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation. Virology. 2000 Dec 5; 278(1):207-16.
    View in: PubMed
  91. Zuccola HJ, Filman DJ, Coen DM, Hogle JM. The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase. Mol Cell. 2000 Feb; 5(2):267-78.
    View in: PubMed
  92. Bridges KG, Hua Q, Brigham-Burke MR, Martin JD, Hensley P, Dahl CE, Digard P, Weiss MA, Coen DM. Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase. J Biol Chem. 2000 Jan 7; 275(1):472-8.
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  93. Talarico CL, Burnette TC, Miller WH, Smith SL, Davis MG, Stanat SC, Ng TI, He Z, Coen DM, Roizman B, Biron KK. Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein. Antimicrob Agents Chemother. 1999 Aug; 43(8):1941-6.
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  94. Prichard MN, Gao N, Jairath S, Mulamba G, Krosky P, Coen DM, Parker BO, Pari GS. A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency. J Virol. 1999 Jul; 73(7):5663-70.
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  95. Huang L, Ishii KK, Zuccola H, Gehring AM, Hwang CB, Hogle J, Coen DM. The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):447-52.
    View in: PubMed
  96. Weisshart K, Chow CS, Coen DM. Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate. J Virol. 1999 Jan; 73(1):55-66.
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  97. Pelosi E, Rozenberg F, Coen DM, Tyler KL. A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Virology. 1998 Dec 20; 252(2):364-72.
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  98. Burkham J, Coen DM, Weller SK. ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase. J Virol. 1998 Dec; 72(12):10100-7.
    View in: PubMed
  99. Hann LE, Cook WJ, Uprichard SL, Knipe DM, Coen DM. The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation. J Virol. 1998 Oct; 72(10):7709-14.
    View in: PubMed
  100. Horsburgh BC, Chen SH, Hu A, Mulamba GB, Burns WH, Coen DM. Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis? J Infect Dis. 1998 Sep; 178(3):618-25.
    View in: PubMed
  101. Chen SH, Cook WJ, Grove KL, Coen DM. Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant. J Virol. 1998 Aug; 72(8):6710-5.
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  102. Netter S, Fauvarque MO, Diez del Corral R, Dura JM, Coen D. white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster. Genetics. 1998 May; 149(1):257-75.
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  103. Coen DM. The persistence of (HIV in) memory (T cells). Trends Microbiol. 1998 Apr; 6(4):129-30.
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  104. Mulamba GB, Hu A, Azad RF, Anderson KP, Coen DM. Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922). Antimicrob Agents Chemother. 1998 Apr; 42(4):971-3.
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  105. Jacobson JG, Chen SH, Cook WJ, Kramer MF, Coen DM. Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice. Virology. 1998 Mar 1; 242(1):161-9.
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  106. Kramer MF, Chen SH, Knipe DM, Coen DM. Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus. J Virol. 1998 Feb; 72(2):1177-85.
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  107. Pelosi E, Mulamba GB, Coen DM. Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants. Antiviral Res. 1998 Jan; 37(1):17-28.
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  108. Hwang YT, Liu BY, Coen DM, Hwang CB. Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. J Virol. 1997 Oct; 71(10):7791-8.
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  109. Chen SH, Kramer MF, Schaffer PA, Coen DM. A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus. J Virol. 1997 Aug; 71(8):5878-84.
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  110. He Z, He YS, Kim Y, Chu L, Ohmstede C, Biron KK, Coen DM. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. J Virol. 1997 Jan; 71(1):405-11.
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  111. Horsburgh BC, Kollmus H, Hauser H, Coen DM. Translational recoding induced by G-rich mRNA sequences that form unusual structures. Cell. 1996 Sep 20; 86(6):949-59.
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  112. Cook WJ, Coen DM. Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation. Virology. 1996 Apr 1; 218(1):204-13.
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  113. Cook WJ, Wobbe KK, Böni J, Coen DM. Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene. Virology. 1996 Apr 1; 218(1):193-203.
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  114. Coen DM. Wheel keeps turning for antiviral combination chemotherapy. Trends Microbiol. 1996 Feb; 4(2):51-2.
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  115. Coen DM. Antiviral drug resistance in herpes simplex virus. Adv Exp Med Biol. 1996; 394:49-57.
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  116. Delattre M, Anxolabéhère D, Coen D. Prevalence of localized rearrangements vs. transpositions among events induced by Drosophila P element transposase on a P transgene. Genetics. 1995 Dec; 141(4):1407-24.
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  117. Chow CS, Coen DM. Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42. J Virol. 1995 Nov; 69(11):6965-71.
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  118. Cook WJ, Lin SM, DeLuca NA, Coen DM. Initiator elements and regulated expression of the herpes simplex virus thymidine kinase gene. J Virol. 1995 Nov; 69(11):7291-4.
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  119. Cook WJ, Gu B, DeLuca NA, Moynihan EB, Coen DM. Induction of transcription by a viral regulatory protein depends on the relative strengths of functional TATA boxes. Mol Cell Biol. 1995 Sep; 15(9):4998-5006.
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  120. Kimberlin DW, Coen DM, Biron KK, Cohen JI, Lamb RA, McKinlay M, Emini EA, Whitley RJ. Molecular mechanisms of antiviral resistance. Antiviral Res. 1995 Apr; 26(4):369-401.
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  121. Kramer MF, Coen DM. Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J Virol. 1995 Mar; 69(3):1389-99.
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  122. Digard P, Williams KP, Hensley P, Brooks IS, Dahl CE, Coen DM. Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1456-60.
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  123. Jacobson J, Kramer M, Rozenberg F, Hu A, Coen DM. Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase. Virology. 1995 Jan 10; 206(1):263-8.
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  124. Digard P, Bebrin WR, Coen DM. Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype. Methods Enzymol. 1995; 262:303-22.
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  125. Coen DM. Acyclovir-resistant, pathogenic herpesviruses. Trends Microbiol. 1994 Dec; 2(12):481-5.
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  126. Weisshart K, Kuo AA, Hwang CB, Kumura K, Coen DM. Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis. J Biol Chem. 1994 Sep 9; 269(36):22788-96.
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  127. Hwang CB, Horsburgh B, Pelosi E, Roberts S, Digard P, Coen DM. A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant. Proc Natl Acad Sci U S A. 1994 Jun 7; 91(12):5461-5.
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  128. Davar G, Kramer MF, Garber D, Roca AL, Andersen JK, Bebrin W, Coen DM, Kosz-Vnenchak M, Knipe DM, Breakefield XO, et al. Gene transfer to sensory neurons using herpes virus vectors. Gene Ther. 1994; 1 Suppl 1:S24.
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  129. Davar G, Kramer MF, Garber D, Roca AL, Andersen JK, Bebrin W, Coen DM, Kosz-Vnenchak M, Knipe DM, Breakefield XO, et al. Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors. J Comp Neurol. 1994 Jan 1; 339(1):3-11.
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  130. Mineta T, Markert JM, Takamiya Y, Coen DM, Rabkin SD, Martuza RL. CNS tumor therapy by attenuated herpes simplex viruses. Gene Ther. 1994; 1 Suppl 1:S78.
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  131. Cai W, Astor TL, Liptak LM, Cho C, Coen DM, Schaffer PA. The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency. J Virol. 1993 Dec; 67(12):7501-12.
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  132. Jacobson JG, Ruffner KL, Kosz-Vnenchak M, Hwang CB, Wobbe KK, Knipe DM, Coen DM. Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia. J Virol. 1993 Nov; 67(11):6903-8.
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  133. Garber DA, Beverley SM, Coen DM. Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis. Virology. 1993 Nov; 197(1):459-62.
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  134. Wobbe KK, Digard P, Staknis D, Coen DM. Unusual regulation of expression of the herpes simplex virus DNA polymerase gene. J Virol. 1993 Sep; 67(9):5419-25.
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  135. Kosz-Vnenchak M, Jacobson J, Coen DM, Knipe DM. Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons. J Virol. 1993 Sep; 67(9):5383-93.
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  136. Markert JM, Malick A, Coen DM, Martuza RL. Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir. Neurosurgery. 1993 Apr; 32(4):597-603.
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  137. Digard P, Chow CS, Pirrit L, Coen DM. Functional analysis of the herpes simplex virus UL42 protein. J Virol. 1993 Mar; 67(3):1159-68.
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  138. Weisshart K, Kuo AA, Painter GR, Wright LL, Furman PA, Coen DM. Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding. Proc Natl Acad Sci U S A. 1993 Feb 1; 90(3):1028-32.
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  139. Digard P, Bebrin WR, Weisshart K, Coen DM. The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication. J Virol. 1993 Jan; 67(1):398-406.
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  140. Sullivan V, Biron KK, Talarico C, Stanat SC, Davis M, Pozzi LM, Coen DM. A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrob Agents Chemother. 1993 Jan; 37(1):19-25.
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  141. Markert JM, Coen DM, Malick A, Mineta T, Martuza RL. Expanded spectrum of viral therapy in the treatment of nervous system tumors. J Neurosurg. 1992 Oct; 77(4):590-4.
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  142. Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature. 1992 Sep 3; 359(6390):85.
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  143. Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature. 1992 Jul 9; 358(6382):162-4.
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  144. Hwang CB, Ruffner KL, Coen DM. A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. J Virol. 1992 Mar; 66(3):1774-6.
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  145. Pelosi E, Hicks KA, Sacks SL, Coen DM. Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet. Adv Exp Med Biol. 1992; 312:151-8.
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  146. Sullivan V, Coen DM. Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs. J Infect Dis. 1991 Oct; 164(4):781-4.
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  147. Gibbs JS, Weisshart K, Digard P, deBruynKops A, Knipe DM, Coen DM. Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site. Mol Cell Biol. 1991 Sep; 11(9):4786-95.
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  148. Lemaitre B, Coen D. P regulatory products repress in vivo the P promoter activity in P-lacZ fusion genes. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4419-23.
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  149. Martuza RL, Malick A, Markert JM, Ruffner KL, Coen DM. Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science. 1991 May 10; 252(5007):854-6.
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  150. Coen DM. The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy. Antiviral Res. 1991 May; 15(4):287-300.
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  151. Bush M, Yager DR, Gao M, Weisshart K, Marcy AI, Coen DM, Knipe DM. Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein. J Virol. 1991 Mar; 65(3):1082-9.
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  152. Imbalzano AN, Coen DM, DeLuca NA. Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene. J Virol. 1991 Feb; 65(2):565-74.
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  153. Marcy AI, Hwang CB, Ruffner KL, Coen DM. Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition. J Virol. 1990 Dec; 64(12):5883-90.
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  154. Coen D. P element regulatory products enhance zeste repression of a P[white duplicated] transgene in Drosophila melanogaster. Genetics. 1990 Dec; 126(4):949-60.
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  155. Gottlieb J, Marcy AI, Coen DM, Challberg MD. The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity. J Virol. 1990 Dec; 64(12):5976-87.
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  156. Kosz-Vnenchak M, Coen DM, Knipe DM. Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses. J Virol. 1990 Nov; 64(11):5396-402.
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  157. Digard P, Coen DM. A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein. J Biol Chem. 1990 Oct 15; 265(29):17393-6.
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  158. Katz JP, Bodin ET, Coen DM. Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants. J Virol. 1990 Sep; 64(9):4288-95.
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  159. Leib DA, Ruffner KL, Hildebrand C, Schaffer PA, Wright GE, Coen DM. Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia. Antimicrob Agents Chemother. 1990 Jun; 34(6):1285-6.
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  160. Marcy AI, Yager DR, Coen DM. Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus. J Virol. 1990 May; 64(5):2208-16.
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  161. Yager DR, Marcy AI, Coen DM. Translational regulation of herpes simplex virus DNA polymerase. J Virol. 1990 May; 64(5):2217-25.
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  162. Marcy AI, Olivo PD, Challberg MD, Coen DM. Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells. Nucleic Acids Res. 1990 Mar 11; 18(5):1207-15.
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  163. Coen DM. Antiviral drug resistance. Ann N Y Acad Sci. 1990; 616:224-37.
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  164. Sacks SL, Wanklin RJ, Reece DE, Hicks KA, Tyler KL, Coen DM. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann Intern Med. 1989 Dec 1; 111(11):893-9.
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  165. Jacobson JG, Leib DA, Goldstein DJ, Bogard CL, Schaffer PA, Weller SK, Coen DM. A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells. Virology. 1989 Nov; 173(1):276-83.
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  166. Böni J, Coen DM. Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene. J Virol. 1989 Sep; 63(9):4088-92.
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  167. Coen DM, Goldstein DJ, Weller SK. Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir. Antimicrob Agents Chemother. 1989 Aug; 33(8):1395-9.
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  168. Leib DA, Bogard CL, Kosz-Vnenchak M, Hicks KA, Coen DM, Knipe DM, Schaffer PA. A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J Virol. 1989 Jul; 63(7):2893-900.
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  169. Coen DM, Kosz-Vnenchak M, Jacobson JG, Leib DA, Bogard CL, Schaffer PA, Tyler KL, Knipe DM. Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4736-40.
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  170. Jacobson JG, Martin SL, Coen DM. A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture. J Virol. 1989 Apr; 63(4):1839-43.
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  171. Irmiere AF, Manos MM, Jacobson JG, Gibbs JS, Coen DM. Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability. Virology. 1989 Feb; 168(2):210-20.
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  172. Leib DA, Coen DM, Bogard CL, Hicks KA, Yager DR, Knipe DM, Tyler KL, Schaffer PA. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J Virol. 1989 Feb; 63(2):759-68.
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  173. Coen DM, Irmiere AF, Jacobson JG, Kerns KM. Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model. Virology. 1989 Feb; 168(2):221-31.
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  174. Gibbs JS, Chiou HC, Bastow KF, Cheng YC, Coen DM. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6672-6.
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  175. Yager DR, Coen DM. Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation. J Virol. 1988 Jun; 62(6):2007-15.
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  176. Biron KK, Fyfe JA, Stanat SC, Leslie LK, Sorrell JB, Lambe CU, Coen DM. A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate. Proc Natl Acad Sci U S A. 1986 Nov; 83(22):8769-73.
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  177. Coen DM, Weinheimer SP, McKnight SL. A genetic approach to promoter recognition during trans induction of viral gene expression. Science. 1986 Oct 3; 234(4772):53-9.
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  178. Field HJ, Coen DM. Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene. J Virol. 1986 Oct; 60(1):286-9.
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  179. Coen DM. General aspects of virus drug resistance with special reference to herpes simplex virus. J Antimicrob Chemother. 1986 Oct; 18 Suppl B:1-10.
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  180. Chiou HC, Kerns KM, Coen DM. Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine. Antimicrob Agents Chemother. 1986 Sep; 30(3):502-4.
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  181. Hall JD, Gibbs JS, Coen DM, Mount DW. Structural organization and unusual codon usage in the DNA polymerase gene from herpes simplex virus type 1. DNA. 1986 Aug; 5(4):281-8.
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  182. Gibbs JS, Chiou HC, Hall JD, Mount DW, Retondo MJ, Weller SK, Coen DM. Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain. Proc Natl Acad Sci U S A. 1985 Dec; 82(23):7969-73.
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  183. Chiou HC, Weller SK, Coen DM. Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors. Virology. 1985 Sep; 145(2):213-26.
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  184. Eisenberg SP, Coen DM, McKnight SL. Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes. Mol Cell Biol. 1985 Aug; 5(8):1940-7.
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  185. Graves BJ, Eisenberg SP, Coen DM, McKnight SL. Alternate utilization of two regulatory domains within the Moloney murine sarcoma virus long terminal repeat. Mol Cell Biol. 1985 Aug; 5(8):1959-68.
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  186. Coen DM, Fleming HE, Leslie LK, Retondo MJ. Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus. J Virol. 1985 Feb; 53(2):477-88.
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  187. Fleming HE, Coen DM. Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin. Antimicrob Agents Chemother. 1984 Sep; 26(3):382-7.
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  188. Schaffer PA, Weller SK, Pancake BA, Coen DM. Genetics of herpes simplex virus. J Invest Dermatol. 1984 Jul; 83(1 Suppl):42s-47s.
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  189. Hall JD, Coen DM, Fisher BL, Weisslitz M, Randall S, Almy RE, Gelep PT, Schaffer PA. Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. Virology. 1984 Jan 15; 132(1):26-37.
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  190. Coen DM, Aschman DP, Gelep PT, Retondo MJ, Weller SK, Schaffer PA. Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus. J Virol. 1984 Jan; 49(1):236-47.
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  191. Weller SK, Aschman DP, Sacks WR, Coen DM, Schaffer PA. Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment. Virology. 1983 Oct 30; 130(2):290-305.
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  192. Coen DM, Furman PA, Aschman DP, Schaffer PA. Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin. Nucleic Acids Res. 1983 Aug 11; 11(15):5287-97.
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  193. Coen DM, Schaffer PA, Furman PA, Keller PM, St Clair MH. Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1. Am J Med. 1982 Jul 20; 73(1A):351-60.
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  194. Coen DM, Furman PA, Gelep PT, Schaffer PA. Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine. J Virol. 1982 Mar; 41(3):909-18.
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  195. Furman PA, Coen DM, St Clair MH, Schaffer PA. Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities. J Virol. 1981 Dec; 40(3):936-41.
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  196. Coen DM, Schaffer PA. Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1. Proc Natl Acad Sci U S A. 1980 Apr; 77(4):2265-9.
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  197. Bedbrook JR, Coen DM, Beaton AR, Bogorad L, Rich A. Location of the single gene for the large subunit of ribulosebisphosphate carboxylase on the maize chloroplast chromosome. J Biol Chem. 1979 Feb 10; 254(3):905-10.
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  198. Link G, Coen DM, Bogorad L. Differential expression of the gene for the large subunit of ribulose bisphosphate carboxylase in maize leaf cell types. Cell. 1978 Nov; 15(3):725-31.
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  199. Grebanier AE, Coen DM, Rich A, Bogorad L. Membrane proteins synthesized but not processed by isolated maize chloroplasts. J Cell Biol. 1978 Sep; 78(3):734-46.
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  200. Bedbrook JR, Link G, Coen DM, Bogorad L. Maize plastid gene expressed during photoregulated development. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3060-4.
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  201. Coen DM, Bedbrook JR, Bogorad L, Rich A. Maize chloroplast DNA fragment encoding the large subunit of ribulosebisphosphate carboxylase. Proc Natl Acad Sci U S A. 1977 Dec; 74(12):5487-91.
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  202. Storti RV, Coen DM, Rich A. Tissue-specific forms of actin in the developing chick. Cell. 1976 Aug; 8(4):521-7.
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  203. Dujon B, Bolotin-Fukuhara M, Coen D, Deutsch J, Netter P, Slonimski PP, Weill L. Mitochondrial genetics. XI. Mutations at the mitochondrial locus omega affecting the recombination of mitochondrial genes in Saccharomyces cerevisiae. Mol Gen Genet. 1976 Jan 16; 143(2):131-65.
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  204. Netter P, Petrochilo E, Slonimski PP, Bolotin-Fukuhara M, Coen D, Deutsch J, Dujon B. Mitochondrial genetics. VII. Allelism and mapping studies of ribosomal mutants resistant to chloramphenicol, erythromycin and spiramycin in S. cerevisiae. Genetics. 1974 Dec; 78(4):1063-100.
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  205. Deutsch J, Dujon B, Netter P, Petrochilo E, Slonimski PP, Bolotin-Fukuhara M, Coen D. Mitochondrial genetics. VI. The petite mutation in Saccharomyces cerevisiae: interrelations between the loss of the p+ factor and the loss of the drug resistance mitochondrial genetic markers. Genetics. 1974 Feb; 76(2):195-219.
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  206. Avner PR, Coen D, Dujon B, Slonimski PP. Mitochondrial genetics. IV. Allelism and mapping studies of oligomycin resistant mutants in S. cerevisiae. Mol Gen Genet. 1973 Sep 5; 125(1):9-52.
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  207. Faye G, Fukuhara H, Grandchamp C, Lazowska J, Michel F, Casey J, Getz GS, Locker J, Rabinowitz M, Bolotin-Fukuhara M, Coen D, Deutsch J, Dujon B, Netter P, Slonimski PP. Mitochondrial nucleic acids in the petite colonie mutants: deletions and repetition of genes. Biochimie. 1973; 55(6):779-92.
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  208. Coen D, Deutsch J, Netter P, Petrochilo E, Slonimski PP. Mitochondrial genetics. I. Methodology and phenomenology. Symp Soc Exp Biol. 1970; 24:449-96.
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