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Jon Clardy, PH.D.

TitleHsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
AddressHarvard Medical School
BCMP, 643 C Bldg.
240 Longwood Ave
Boston MA 02115
Phone617/432-2845
Fax617/432-6642

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
ICCB-Longwood Screening Facility (HMS) - Core services (5), Gene knockdown screening libraries (22), Instruments (38), Small molecule Screening libraries (62) and Software (3)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy J. A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proc Natl Acad Sci U S A. 2013 Sep 3; 110(36):14528-33.
    View in: PubMed
  2. Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MA. Production of a-Galactosylceramide by a Prominent Member of the Human Gut Microbiota. PLoS Biol. 2013 Jul; 11(7):e1001610.
    View in: PubMed
  3. Derbyshire ER, Clardy J. Closing in on a new treatment for sleeping sickness. Elife. 2013; 2:e01042.
    View in: PubMed
  4. Sakai N, Iwata R, Yokoi S, Butcher RA, Clardy J, Tomioka M, Iino Y. A Sexually Conditioned Switch of Chemosensory Behavior in C. elegans. PLoS One. 2013; 8(7):e68676.
    View in: PubMed
  5. Kim KH, Choi SU, Son MW, Choi SZ, Clardy J, Lee KR. Pharbinilic Acid, an Allogibberic Acid from Morning Glory (Pharbitis nil). J Nat Prod. 2013 Jul 26; 76(7):1376-9.
    View in: PubMed
  6. Cheng B, Cao S, Vasquez V, Annamalai T, Tamayo-Castillo G, Clardy J, Tse-Dinh YC. Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor. PLoS One. 2013; 8(4):e60770.
    View in: PubMed
  7. Stallforth P, Clardy J. X-ray crystallography: One size fits most. Nature. 2013 Mar 28; 495(7442):456-7.
    View in: PubMed
  8. Cryan LM, Bazinet L, Habeshian KA, Cao S, Clardy J, Christensen KA, Rogers MS. 1,2,3,4,6-Penta-O-galloyl-ß-d-glucopyranose Inhibits Angiogenesis via Inhibition of Capillary Morphogenesis Gene 2. J Med Chem. 2013 Mar 14; 56(5):1940-5.
    View in: PubMed
  9. Böttcher T, Kolodkin-Gal I, Kolter R, Losick R, Clardy J. Synthesis and activity of biomimetic biofilm disruptors. J Am Chem Soc. 2013 Feb 27; 135(8):2927-30.
    View in: PubMed
  10. Chandler JR, Truong TT, Silva PM, Seyedsayamdost MR, Carr G, Radey M, Jacobs MA, Sims EH, Clardy J, Greenberg EP. Bactobolin resistance is conferred by mutations in the l2 ribosomal protein. MBio. 2012; 3(6).
    View in: PubMed
  11. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2012 Dec 10; 30(1):108-60.
    View in: PubMed
  12. Harris ES, Cao S, Schoville SD, Dong C, Wang W, Jian Z, Zhao Z, Eisenberg DM, Clardy J. Selection for high oridonin yield in the chinese medicinal plant isodon (lamiaceae) using a combined phylogenetics and population genetics approach. PLoS One. 2012; 7(11):e50753.
    View in: PubMed
  13. Alegado RA, Brown LW, Cao S, Dermenjian RK, Zuzow R, Fairclough SR, Clardy J, King N. A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals. elife. 2012; 1:e00013.
    View in: PubMed
  14. Adler C, Corbalán NS, Seyedsayamdost MR, Pomares MF, de Cristóbal RE, Clardy J, Kolter R, Vincent PA. Catecholate siderophores protect bacteria from pyochelin toxicity. PLoS One. 2012; 7(10):e46754.
    View in: PubMed
  15. Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J. Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp. J Nat Prod. 2012 Oct 26; 75(10):1806-9.
    View in: PubMed
  16. Stallforth P, Clardy J. Protein evolution: when two become three. Curr Biol. 2012 Sep 11; 22(17):R685-7.
    View in: PubMed
  17. Traxler MF, Seyedsayamdost MR, Clardy J, Kolter R. Interspecies modulation of bacterial development through iron competition and siderophore piracy. Mol Microbiol. 2012 Nov; 86(3):628-44.
    View in: PubMed
  18. Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CB. Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa. ACS Chem Neurosci. 2012 Nov 21; 3(11):941-51.
    View in: PubMed
  19. Seyedsayamdost MR, Cleto S, Carr G, Vlamakis H, João Vieira M, Kolter R, Clardy J. Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. J Am Chem Soc. 2012 Aug 22; 134(33):13550-3.
    View in: PubMed
  20. Cao S, Cryan L, Habeshian KA, Murillo C, Tamayo-Castillo G, Rogers MS, Clardy J. Phenolic compounds as antiangiogenic CMG2 inhibitors from Costa Rican endophytic fungi. Bioorg Med Chem Lett. 2012 Sep 15; 22(18):5885-8.
    View in: PubMed
  21. Somvanshi VS, Sloup RE, Crawford JM, Martin AR, Heidt AJ, Kim KS, Clardy J, Ciche TA. A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. Science. 2012 Jul 6; 337(6090):88-93.
    View in: PubMed
  22. Chen Y, Cao S, Chai Y, Clardy J, Kolter R, Guo JH, Losick R. A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants. Mol Microbiol. 2012 Aug; 85(3):418-30.
    View in: PubMed
  23. Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy J. Small molecule perimeter defense in entomopathogenic bacteria. Proc Natl Acad Sci U S A. 2012 Jul 3; 109(27):10821-6.
    View in: PubMed
  24. Carr G, Poulsen M, Klassen JL, Hou Y, Wyche TP, Bugni TS, Currie CR, Clardy J. Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin. Org Lett. 2012 Jun 1; 14(11):2822-5.
    View in: PubMed
  25. Derbyshire ER, Prudêncio M, Mota MM, Clardy J. Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8511-6.
    View in: PubMed
  26. Crawford JM, Clardy J. Microbial genome mining answers longstanding biosynthetic questions. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7589-90.
    View in: PubMed
  27. Kolodkin-Gal I, Cao S, Chai L, Böttcher T, Kolter R, Clardy J, Losick R. A self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell. 2012 Apr 27; 149(3):684-92.
    View in: PubMed
  28. Cao S, McMillin DW, Tamayo G, Delmore J, Mitsiades CS, Clardy J. Inhibition of tumor cells interacting with stromal cells by xanthones isolated from a Costa Rican Penicillium sp. J Nat Prod. 2012 Apr 27; 75(4):793-7.
    View in: PubMed
  29. Derbyshire ER, Mazitschek R, Clardy J. Characterization of Plasmodium liver stage inhibition by halofuginone. ChemMedChem. 2012 May; 7(5):844-9.
    View in: PubMed
  30. Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PI. A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. PLoS One. 2012; 7(2):e31307.
    View in: PubMed
  31. Seyedsayamdost MR, Traxler MF, Clardy J, Kolter R. Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. Methods Enzymol. 2012; 517:89-109.
    View in: PubMed
  32. Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10.
    View in: PubMed
  33. Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA. Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol. 2012 Feb 17; 7(2):340-9.
    View in: PubMed
  34. Seyedsayamdost MR, Carr G, Kolter R, Clardy J. Roseobacticides: small molecule modulators of an algal-bacterial symbiosis. J Am Chem Soc. 2011 Nov 16; 133(45):18343-9.
    View in: PubMed
  35. Crawford JM, Mahlstedt SA, Malcolmson SJ, Clardy J, Walsh CT. Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. Chem Biol. 2011 Sep 23; 18(9):1102-12.
    View in: PubMed
  36. Derbyshire ER, Mota MM, Clardy J. The next opportunity in anti-malaria drug discovery: the liver stage. PLoS Pathog. 2011 Sep; 7(9):e1002178.
    View in: PubMed
  37. Crawford JM, Portmann C, Kontnik R, Walsh CT, Clardy J. NRPS substrate promiscuity diversifies the xenematides. Org Lett. 2011 Oct 7; 13(19):5144-7.
    View in: PubMed
  38. Harris ES, Cao S, Littlefield BA, Craycroft JA, Scholten R, Kaptchuk T, Fu Y, Wang W, Liu Y, Chen H, Zhao Z, Clardy J, Woolf AD, Eisenberg DM. Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines. Sci Total Environ. 2011 Sep 15; 409(20):4297-305.
    View in: PubMed
  39. Seyedsayamdost MR, Traxler MF, Zheng SL, Kolter R, Clardy J. Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. J Am Chem Soc. 2011 Aug 3; 133(30):11434-7.
    View in: PubMed
  40. Carr G, Seyedsayamdost MR, Chandler JR, Greenberg EP, Clardy J. Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264. Org Lett. 2011 Jun 17; 13(12):3048-51.
    View in: PubMed
  41. Crawford JM, Clardy J. Bacterial symbionts and natural products. Chem Commun (Camb). 2011 Jul 21; 47(27):7559-66.
    View in: PubMed
  42. Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Jun; 55(6):2612-22.
    View in: PubMed
  43. Harris ES, Erickson SD, Tolopko AN, Cao S, Craycroft JA, Scholten R, Fu Y, Wang W, Liu Y, Zhao Z, Clardy J, Shamu CE, Eisenberg DM. Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs. J Ethnopharmacol. 2011 May 17; 135(2):590-3.
    View in: PubMed
  44. Seyedsayamdost MR, Case RJ, Kolter R, Clardy J. The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nat Chem. 2011 Apr; 3(4):331-5.
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  45. Marks KM, Park ES, Arefolov A, Russo K, Ishihara K, Ring JE, Clardy J, Clarke AS, Pelish HE. The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes. J Nat Prod. 2011 Apr 25; 74(4):567-73.
    View in: PubMed
  46. Poulsen M, Oh DC, Clardy J, Currie CR. Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. PLoS One. 2011; 6(2):e16763.
    View in: PubMed
  47. Oh DC, Poulsen M, Currie CR, Clardy J. Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp. Org Lett. 2011 Feb 18; 13(4):752-5.
    View in: PubMed
  48. Eisenberg DM, Harris ES, Littlefield BA, Cao S, Craycroft JA, Scholten R, Bayliss P, Fu Y, Wang W, Qiao Y, Zhao Z, Chen H, Liu Y, Kaptchuk T, Hahn WC, Wang X, Roberts T, Shamu CE, Clardy J. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. Fitoterapia. 2011 Jan; 82(1):17-33.
    View in: PubMed
  49. Mao Y, Xu X, Xu W, Ishida Y, Leal WS, Ames JB, Clardy J. Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone. Proc Natl Acad Sci U S A. 2010 Nov 2; 107(44):19102-7.
    View in: PubMed
  50. Cao S, Blodgett JA, Clardy J. Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain. Org Lett. 2010 Oct 15; 12(20):4652-4.
    View in: PubMed
  51. Cao S, Ross L, Tamayo G, Clardy J. Asterogynins: secondary metabolites from a Costa Rican endophytic fungus. Org Lett. 2010 Oct 15; 12(20):4661-3.
    View in: PubMed
  52. Crawford JM, Clardy J. Biosynthesis: not just passing through. Nat Chem. 2010 Oct; 2(10):805-7.
    View in: PubMed
  53. Yamada K, Hirotsu T, Matsuki M, Butcher RA, Tomioka M, Ishihara T, Clardy J, Kunitomo H, Iino Y. Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science. 2010 Sep 24; 329(5999):1647-50.
    View in: PubMed
  54. Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R. A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity. Org Lett. 2010 Sep 17; 12(18):3998-4001.
    View in: PubMed
  55. Schloss PD, Allen HK, Klimowicz AK, Mlot C, Gross JA, Savengsuksa S, McEllin J, Clardy J, Ruess RW, Handelsman J. Psychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin. DNA Cell Biol. 2010 Sep; 29(9):533-41.
    View in: PubMed
  56. Kontnik R, Crawford JM, Clardy J. Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens. ACS Chem Biol. 2010 Jul 16; 5(7):659-65.
    View in: PubMed
  57. Blodgett JA, Oh DC, Cao S, Currie CR, Kolter R, Clardy J. Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. Proc Natl Acad Sci U S A. 2010 Jun 29; 107(26):11692-7.
    View in: PubMed
  58. Kolodkin-Gal I, Romero D, Cao S, Clardy J, Kolter R, Losick R. D-amino acids trigger biofilm disassembly. Science. 2010 Apr 30; 328(5978):627-9.
    View in: PubMed
  59. Dawlaty J, Zhang X, Fischbach MA, Clardy J. Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases. J Nat Prod. 2010 Mar 26; 73(3):441-6.
    View in: PubMed
  60. D'Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, Clardy J, Lewis K. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol. 2010 Mar 26; 17(3):254-64.
    View in: PubMed
  61. Cronan JM, Lee A, Liang J, Clardy J, Cardellina JH. Chemical modification of the insecticidal briantheins X and Y. J Nat Prod. 2010 Mar 26; 73(3):346-51.
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  62. Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J. Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Org Lett. 2010 Feb 19; 12(4):716-9.
    View in: PubMed
  63. Ndiaye D, Patel V, Demas A, LeRoux M, Ndir O, Mboup S, Clardy J, Lakshmanan V, Daily JP, Wirth DF. A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal. Am J Trop Med Hyg. 2010 Feb; 82(2):228-30.
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  64. Blasiak LC, Clardy J. Discovery of 3-formyl-tyrosine metabolites from Pseudoalteromonas tunicata through heterologous expression. J Am Chem Soc. 2010 Jan 27; 132(3):926-7.
    View in: PubMed
  65. Crawford JM, Kontnik R, Clardy J. Regulating alternative lifestyles in entomopathogenic bacteria. Curr Biol. 2010 Jan 12; 20(1):69-74.
    View in: PubMed
  66. Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J. Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21984-9.
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  67. Hollenhorst MA, Clardy J, Walsh CT. The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. Biochemistry. 2009 Nov 3; 48(43):10467-72.
    View in: PubMed
  68. Martyn DC, Nijjar A, Celatka CA, Mazitschek R, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Danthi S, Clardy J. Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines. Bioorg Med Chem Lett. 2010 Jan 1; 20(1):228-31.
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  69. Martyn DC, Cortese JF, Tyndall E, Dick J, Mazitschek R, Munoz B, Clardy J. Antiplasmodial activity of piperazine sulfonamides. Bioorg Med Chem Lett. 2010 Jan 1; 20(1):218-21.
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  70. Kim K, Sato K, Shibuya M, Zeiger DM, Butcher RA, Ragains JR, Clardy J, Touhara K, Sengupta P. Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. Science. 2009 Nov 13; 326(5955):994-8.
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  71. Lam H, Oh DC, Cava F, Takacs CN, Clardy J, de Pedro MA, Waldor MK. D-amino acids govern stationary phase cell wall remodeling in bacteria. Science. 2009 Sep 18; 325(5947):1552-5.
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  72. Martyn DC, Beletsky G, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Liang B, Clardy J. Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum. Bioorg Med Chem Lett. 2009 Oct 1; 19(19):5657-60.
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  73. Butcher RA, Ragains JR, Clardy J. An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations. Org Lett. 2009 Jul 16; 11(14):3100-3.
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  74. Miller SJ, Clardy J. Natural products: Beyond grind and find. Nat Chem. 2009 Jul; 1(4):261-3.
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  75. Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009 Jun 24; 29(25):8236-47.
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  76. Clardy J, Fischbach MA, Currie CR. The natural history of antibiotics. Curr Biol. 2009 Jun 9; 19(11):R437-41.
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  77. Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L. A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009 Aug 1; 19(15):4223-7.
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  78. Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem. 2009 Apr 23; 52(8):2185-7.
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  79. Macosko EZ, Pokala N, Feinberg EH, Chalasani SH, Butcher RA, Clardy J, Bargmann CI. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. Nature. 2009 Apr 30; 458(7242):1171-5.
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  80. Oh DC, Poulsen M, Currie CR, Clardy J. Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis. Nat Chem Biol. 2009 Jun; 5(6):391-3.
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  81. Rush MA, Baniecki ML, Mazitschek R, Cortese JF, Wiegand R, Clardy J, Wirth DF. Colorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrob Agents Chemother. 2009 Jun; 53(6):2564-8.
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  82. Hoekstra AV, Sefton EC, Berry E, Lu Z, Hardt J, Marsh E, Yin P, Clardy J, Chakravarti D, Bulun S, Kim JJ. Progestins activate the AKT pathway in leiomyoma cells and promote survival. J Clin Endocrinol Metab. 2009 May; 94(5):1768-74.
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  83. Oh DC, Scott JJ, Currie CR, Clardy J. Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp. Org Lett. 2009 Feb 5; 11(3):633-6.
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  84. Wieland Brown LC, Acker MG, Clardy J, Walsh CT, Fischbach MA. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2549-53.
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  85. Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY. Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1875-9.
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  86. Berry E, Hardt JL, Clardy J, Lurain JR, Kim JJ. Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1. Gynecol Oncol. 2009 Feb; 112(2):331-6.
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  87. Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 1; 19(3):972-5.
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  88. Martyn DC, Ramirez AP, Beattie MJ, Cortese JF, Patel V, Rush MA, Woerpel KA, Clardy J. Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6521-4.
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  89. Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy J. Actin-aggregating cucurbitacins from Physocarpus capitatus. J Nat Prod. 2008 Nov; 71(11):1927-9.
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  90. Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85.
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  91. Scott JJ, Oh DC, Yuceer MC, Klepzig KD, Clardy J, Currie CR. Bacterial protection of beetle-fungus mutualism. Science. 2008 Oct 3; 322(5898):63.
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  92. Fernández de Mattos S, Villalonga P, Clardy J, Lam EW. FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells. Mol Cancer Ther. 2008 Oct; 7(10):3237-46.
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  93. Butcher RA, Ragains JR, Kim E, Clardy J. A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14288-92.
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  94. Kontnik R, Clardy J. Codinaeopsin, an antimalarial fungal polyketide. Org Lett. 2008 Sep 18; 10(18):4149-51.
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  95. Kontnik R, Bosak T, Butcher RA, Brocks JJ, Losick R, Clardy J, Pearson A. Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores. Org Lett. 2008 Aug 21; 10(16):3551-4.
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  96. Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008; 3(5):e2082.
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  97. Mazitschek R, Patel V, Wirth DF, Clardy J. Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. Bioorg Med Chem Lett. 2008 May 1; 18(9):2809-12.
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  98. Fischbach MA, Walsh CT, Clardy J. The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4601-8.
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  99. Georgiades SN, Clardy J. Synthetic libraries of tyrosine-derived bacterial metabolites. Bioorg Med Chem Lett. 2008 May 15; 18(10):3117-21.
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  100. Lautenschlager C, Leal WS, Clardy J. Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition. Structure. 2007 Sep; 15(9):1148-54.
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  101. Schmitz K, Haggarty SJ, McPherson OM, Clardy J, Koehler AN. Detecting binding interactions using microarrays of natural product extracts. J Am Chem Soc. 2007 Sep 19; 129(37):11346-7.
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  102. Junker LM, Clardy J. High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. Antimicrob Agents Chemother. 2007 Oct; 51(10):3582-90.
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  103. Fischbach MA, Clardy J. One pathway, many products. Nat Chem Biol. 2007 Jul; 3(7):353-5.
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  104. Clardy J, Brady SF. Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium. J Bacteriol. 2007 Sep; 189(17):6487-9.
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  105. Butcher RA, Fujita M, Schroeder FC, Clardy J. Small-molecule pheromones that control dauer development in Caenorhabditis elegans. Nat Chem Biol. 2007 Jul; 3(7):420-2.
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  106. Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy J. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1506-9.
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  107. Schroeder FC, Gibson DM, Churchill AC, Sojikul P, Wursthorn EJ, Krasnoff SB, Clardy J. Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library. Angew Chem Int Ed Engl. 2007; 46(6):901-4.
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  108. Martyn DC, Jones DC, Fairlamb AH, Clardy J. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1; 17(5):1280-3.
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  109. Clardy J, Fischbach MA, Walsh CT. New antibiotics from bacterial natural products. Nat Biotechnol. 2006 Dec; 24(12):1541-50.
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  110. Baniecki ML, Wirth DF, Clardy J. High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother. 2007 Feb; 51(2):716-23.
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  111. Amagata T, Morinaka BI, Amagata A, Tenney K, Valeriote FA, Lobkovsky E, Clardy J, Crews P. A chemical study of cyclic depsipeptides produced by a sponge-derived fungus. J Nat Prod. 2006 Nov; 69(11):1560-5.
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  112. Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 2006 Oct; 10(4):321-30.
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  113. Georgiades SN, Clardy J. Preparation of a psammaplysene-based library. Org Lett. 2006 Sep 14; 8(19):4251-4.
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  114. Van Wagoner RM, Clardy J. FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding. Structure. 2006 Sep; 14(9):1425-35.
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  115. Maloney KN, Hao W, Xu J, Gibbons J, Hucul J, Roll D, Brady SF, Schroeder FC, Clardy J. Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus. Org Lett. 2006 Aug 31; 8(18):4067-70.
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  116. Jin M, Fischbach MA, Clardy J. A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid. J Am Chem Soc. 2006 Aug 23; 128(33):10660-1.
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  117. Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem. 2006 Oct 6; 281(40):29897-904.
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  118. Nonato MC, Widom J, Clardy J. Human methionine aminopeptidase type 2 in complex with L- and D-methionine. Bioorg Med Chem Lett. 2006 May 15; 16(10):2580-3.
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  119. Thammana S, Suzuki H, Lobkovsky E, Clardy J, Shimizu Y. Isolation and structure assignment of an iminotetrasaccharide from a cultured filamentous cyanobacterium Anabaena sp. J Nat Prod. 2006 Mar; 69(3):365-8.
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  120. Hurt DE, Widom J, Clardy J. Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor. Acta Crystallogr D Biol Crystallogr. 2006 Mar; 62(Pt 3):312-23.
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  121. Clardy J. Stopping trouble before it starts. ACS Chem Biol. 2006 Feb 17; 1(1):17-9.
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  123. Brady SF, Clardy J. Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angew Chem Int Ed Engl. 2005 Nov 4; 44(43):7063-5.
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  124. Brady SF, Clardy J. Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom. Angew Chem Int Ed Engl. 2005 Nov 4; 44(43):7045-8.
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  125. Lautenschlager C, Leal WS, Clardy J. Coil-to-helix transition and ligand release of Bombyx mori pheromone-binding protein. Biochem Biophys Res Commun. 2005 Oct 7; 335(4):1044-50.
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  126. Georgiades SN, Clardy J. Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export. Org Lett. 2005 Sep 15; 7(19):4091-4.
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  127. Clardy J. Using genomics to deliver natural products from symbiotic bacteria. Genome Biol. 2005; 6(9):232.
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  128. Brady SF, Clardy J. N-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli. Org Lett. 2005 Aug 18; 7(17):3613-6.
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  129. Weibel DB, Lee A, Mayer M, Brady SF, Bruzewicz D, Yang J, Diluzio WR, Clardy J, Whitesides GM. Bacterial printing press that regenerates its ink: contact-printing bacteria using hydrogel stamps. Langmuir. 2005 Jul 5; 21(14):6436-42.
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  130. Schroeder FC, Kau TR, Silver PA, Clardy J. The psammaplysenes, specific inhibitors of FOXO1a nuclear export. J Nat Prod. 2005 Apr; 68(4):574-6.
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  131. Clardy J, Walsh C. Lessons from natural molecules. Nature. 2004 Dec 16; 432(7019):829-37.
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  132. Brady SF, Chao CJ, Clardy J. Long-chain N-acyltyrosine synthases from environmental DNA. Appl Environ Microbiol. 2004 Nov; 70(11):6865-70.
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  133. Brady SF, Clardy J. Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water. J Nat Prod. 2004 Aug; 67(8):1283-6.
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  134. Candi E, Paradisi A, Terrinoni A, Pietroni V, Oddi S, Cadot B, Jogini V, Meiyappan M, Clardy J, Finazzi-Agro A, Melino G. Transglutaminase 5 is regulated by guanine-adenine nucleotides. Biochem J. 2004 Jul 1; 381(Pt 1):313-9.
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  135. Chen H, Fujita M, Feng Q, Clardy J, Fink GR. Tyrosol is a quorum-sensing molecule in Candida albicans. Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14):5048-52.
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  136. Stierle DB, Stierle AA, Hobbs JD, Stokken J, Clardy J. Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism. Org Lett. 2004 Mar 18; 6(6):1049-52.
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  137. Sonnenschein RN, Farias JJ, Tenney K, Mooberry SL, Lobkovsky E, Clardy J, Crews P. A further study of the cytotoxic constituents of a milnamide-producing sponge. Org Lett. 2004 Mar 4; 6(5):779-82.
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  138. Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 2003 Dec; 4(6):463-76.
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  139. Amagata T, Amagata A, Tenney K, Valeriote FA, Lobkovsky E, Clardy J, Crews P. Unusual C25 steroids produced by a sponge-derived Penicillium citrinum. Org Lett. 2003 Nov 13; 5(23):4393-6.
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  140. Calero G, Gupta P, Nonato MC, Tandel S, Biehl ER, Hofmann SL, Clardy J. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2. J Biol Chem. 2003 Sep 26; 278(39):37957-64.
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  141. Jin M, Liu L, Wright SA, Beer SV, Clardy J. Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes. Angew Chem Int Ed Engl. 2003 Jun 30; 42(25):2898-901.
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  142. Jin M, Wright SA, Beer SV, Clardy J. The biosynthetic gene cluster of Pantocin a provides insights into biosynthesis and a tool for screening. Angew Chem Int Ed Engl. 2003 Jun 30; 42(25):2902-5.
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  143. Dahl JE, Moldowan JM, Peakman TM, Clardy JC, Lobkovsky E, Olmstead MM, May PW, Davis TJ, Steeds JW, Peters KE, Pepper A, Ekuan A, Carlson RM. Isolation and structural proof of the large diamond molecule, cyclohexamantane (C26H30). Angew Chem Int Ed Engl. 2003 May 9; 42(18):2040-4.
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  144. Garo E, Starks CM, Jensen PR, Fenical W, Lobkovsky E, Clardy J. Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens. J Nat Prod. 2003 Mar; 66(3):423-6.
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  145. Amagata T, Whitman S, Johnson TA, Stessman CC, Loo CP, Lobkovsky E, Clardy J, Crews P, Holman TR. Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb; 66(2):230-5.
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  146. Brady SF, Clardy J. Synthesis of long-chain fatty acid enol esters isolated from an environmental DNA clone. Org Lett. 2003 Jan 23; 5(2):121-4.
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  147. Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci U S A. 2003 Feb 4; 100(3):868-73.
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  148. Thale Z, Johnson T, Tenney K, Wenzel PJ, Lobkovsky E, Clardy J, Media J, Pietraszkiewicz H, Valeriote FA, Crews P. Structures and cytotoxic properties of sponge-derived bisannulated acridines. J Org Chem. 2002 Dec 27; 67(26):9384-91.
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  149. Calero G, Wilson KF, Ly T, Rios-Steiner JL, Clardy JC, Cerione RA. Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. Nat Struct Biol. 2002 Dec; 9(12):912-7.
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  150. Gillespie DE, Brady SF, Bettermann AD, Cianciotto NP, Liles MR, Rondon MR, Clardy J, Goodman RM, Handelsman J. Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA. Appl Environ Microbiol. 2002 Sep; 68(9):4301-6.
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  151. Brady SF, Chao CJ, Clardy J. New natural product families from an environmental DNA (eDNA) gene cluster. J Am Chem Soc. 2002 Aug 28; 124(34):9968-9.
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  152. Salomon CE, Williams DH, Lobkovsky E, Clardy JC, Faulkner DJ. Relative and absolute stereochemistry of the didemnaketals, metabolites of a Palauan ascidian, Didemnum sp. Org Lett. 2002 May 16; 4(10):1699-702.
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  153. Anjaneyulu AS, Rao VL, Lobkovsky E, Clardy J. Ceriopsin E, a new epoxy ent-kaurene diterpenoid from Ceriops decandra. J Nat Prod. 2002 Apr; 65(4):592-4.
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  154. Wagenaar MM, Gibson DM, Clardy J. Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis. Org Lett. 2002 Mar 7; 4(5):671-3.
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  155. Liu S, Cerione RA, Clardy J. Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5):2743-7.
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  156. Nonato MC, Widom J, Clardy J. Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha. J Biol Chem. 2002 May 10; 277(19):17057-61.
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  157. Cueto M, Jensen PR, Kauffman C, Fenical W, Lobkovsky E, Clardy J. Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge. J Nat Prod. 2001 Nov; 64(11):1444-6.
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  158. Sutton AE, Clardy J. Synthesis and biological evaluation of analogues of the antibiotic pantocin B. J Am Chem Soc. 2001 Oct 17; 123(41):9935-46.
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  159. Brady SF, Bondi SM, Clardy J. The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus. J Am Chem Soc. 2001 Oct 10; 123(40):9900-1.
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  160. Wagenaar MM, Clardy J. Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint. J Nat Prod. 2001 Aug; 64(8):1006-9.
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  161. Brady SF, Chao CJ, Handelsman J, Clardy J. Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA. Org Lett. 2001 Jun 28; 3(13):1981-4.
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  162. Wagenaar MM, Clardy J. Two new roridins isolated from Myrothecium sp. J Antibiot (Tokyo). 2001 Jun; 54(6):517-20.
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  163. Qiu SX, Nguyen VH, Le TX, Gu JQ, Lobkovsky E, Tran CK, Soejarto DD, Clardy J, Pezzuto JM, Dong Y, Mai VT, Le MH, Fong HH. A pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography. Phytochemistry. 2001 Apr; 56(7):775-80.
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  164. Brady SF, Wagenaar MM, Singh MP, Janso JE, Clardy J. The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Org Lett. 2000 Dec 14; 2(25):4043-6.
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  165. Brady SF, Singh MP, Janso JE, Clardy J. Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Org Lett. 2000 Dec 14; 2(25):4047-9.
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  166. Wagenaar MM, Corwin J, Strobel G, Clardy J. Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. J Nat Prod. 2000 Dec; 63(12):1692-5.
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  167. Jiménez JI, Yoshida WY, Scheuer PJ, Lobkovsky E, Clardy J, Kelly M. Honulactones: new bishomoscalarane sesterterpenes from the Indonesian sponge Strepsichordaia aliena. J Org Chem. 2000 Oct 20; 65(21):6837-40.
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  168. Brady SF, Clardy J. CR377, a new pentaketide antifungal agent isolated from an endophytic fungus. J Nat Prod. 2000 Oct; 63(10):1447-8.
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  169. Bittinger MA, Gross JA, Widom J, Clardy J, Handelsman J. Rhizobium etli CE3 carries vir gene homologs on a self-transmissible plasmid. Mol Plant Microbe Interact. 2000 Sep; 13(9):1019-21.
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  170. Das AK, Bellizzi JJ, Tandel S, Biehl E, Clardy J, Hofmann SL. Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride. J Biol Chem. 2000 Aug 4; 275(31):23847-51.
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  171. Rondon MR, August PR, Bettermann AD, Brady SF, Grossman TH, Liles MR, Loiacono KA, Lynch BA, MacNeil IA, Minor C, Tiong CL, Gilman M, Osburne MS, Clardy J, Handelsman J, Goodman RM. Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms. Appl Environ Microbiol. 2000 Jun; 66(6):2541-7.
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  172. Bellizzi JJ, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J. The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4573-8.
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  173. Li JY, Strobel G, Harper J, Lobkovsky E, Clardy J. Cryptocin, a potent tetramic acid antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Org Lett. 2000 Mar 23; 2(6):767-70.
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  174. Singh MP, Janso JE, Luckman SW, Brady SF, Clardy J, Greenstein M, Maiese WM. Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115. J Antibiot (Tokyo). 2000 Mar; 53(3):256-61.
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  175. Sutton AE, Clardy J. The total synthesis of pantocin B. Org Lett. 2000 Feb 10; 2(3):319-21.
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  176. Sandler BH, Nikonova L, Leal WS, Clardy J. Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex. Chem Biol. 2000 Feb; 7(2):143-51.
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  177. Liu S, Neidhardt EA, Grossman TH, Ocain T, Clardy J. Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure. 2000 Jan 15; 8(1):25-33.
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  178. Bellizzi JJ, Widom J, Kemp CW, Clardy J. Producing selenomethionine-labeled proteins with a baculovirus expression vector system. Structure. 1999 Nov 15; 7(11):R263-7.
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  179. Stohl EA, Brady SF, Clardy J, Handelsman J. ZmaR, a novel and widespread antibiotic resistance determinant that acetylates zwittermicin A. J Bacteriol. 1999 Sep; 181(17):5455-60.
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  180. Jiang J, Li AH, Jang SY, Chang L, Melman N, Moro S, Ji X, Lobkovsky EB, Clardy JC, Jacobson KA. Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists. J Med Chem. 1999 Aug 12; 42(16):3055-65.
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  181. Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J. Structure of the PIN/LC8 dimer with a bound peptide. Nat Struct Biol. 1999 Aug; 6(8):735-40.
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  182. Moe ST, Shimizu SM, Smith DL, Van Wagenen BC, DelMar EG, Balandrin MF, Chien Y, Raszkiewicz JL, Artman LD, Mueller AL, Lobkovsky E, Clardy J. Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: a potent and stereoselective NMDA receptor antagonist. Bioorg Med Chem Lett. 1999 Jul 19; 9(14):1915-20.
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  183. Odagaki Y, Hayashi A, Okada K, Hirotsu K, Kabashima T, Ito K, Yoshimoto T, Tsuru D, Sato M, Clardy J. The crystal structure of pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals a new structure for a cysteine protease. Structure. 1999 Apr 15; 7(4):399-411.
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  184. Liang J, Choi J, Clardy J. Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr D Biol Crystallogr. 1999 Apr; 55(Pt 4):736-44.
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  185. Clardy J. Borrowing to make ends meet. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):1826-7.
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  186. Kongsaeree P, Liang J, Jensen RA, Clardy J. Crystallization and preliminary X-ray crystallographic analysis of the Pseudomonas aeruginosa cyclohexadienyl dehydratase. Acta Crystallogr D Biol Crystallogr. 1999 Feb; 55(Pt 2):539-41.
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  187. Gunasekera SP, McCarthy PJ, Longley RE, Pomponi SA, Wright AE, Lobkovsky E, Clardy J. Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella. J Nat Prod. 1999 Jan; 62(1):173-5.
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  188. Nassar N, Hoffman GR, Manor D, Clardy JC, Cerione RA. Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nat Struct Biol. 1998 Dec; 5(12):1047-52.
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  189. Qiu SX, Sun HD, Lobkovsky E, Chai H, Clardy J, Farnsworth NR, Pezzuto JM, Fong HH. Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus. Planta Med. 1998 Dec; 64(8):728-31.
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  190. Liu S, Widom J, Kemp CW, Crews CM, Clardy J. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science. 1998 Nov 13; 282(5392):1324-7.
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  191. Handelsman J, Rondon MR, Brady SF, Clardy J, Goodman RM. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chem Biol. 1998 Oct; 5(10):R245-9.
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  192. Lee AY, Zhang S, Kongsaeree P, Clardy J, Ganem B, Erickson JW, Xie D. Thermodynamics of a transition state analogue inhibitor binding to Escherichia coli chorismate mutase: probing the charge state of an active site residue and its role in inhibitor binding and catalysis. Biochemistry. 1998 Jun 23; 37(25):9052-7.
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  193. Zhang S, Pohnert G, Kongsaeree P, Wilson DB, Clardy J, Ganem B. Chorismate mutase-prephenate dehydratase from Escherichia coli. Study of catalytic and regulatory domains using genetically engineered proteins. J Biol Chem. 1998 Mar 13; 273(11):6248-53.
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  194. Schultz LW, Clardy J. Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12. Bioorg Med Chem Lett. 1998 Jan 6; 8(1):1-6.
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  195. Jaspars M, Jackson E, Lobkovsky E, Clardy J, Diaz MC, Crews P. Using scalarane sesterterpenes to examine a sponge taxonomic anomaly. J Nat Prod. 1997 Jun; 60(6):556-61.
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  196. Antifungal diterpenoid alkaloids from Delphinium denudatum. J Nat Prod. 1997 May; 60(5):472-4.
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  197. Schroeder DR, Colson KL, Klohr SE, Lee MS, Matson JA, Brinen LS, Clardy J. Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis. J Antibiot (Tokyo). 1996 Sep; 49(9):865-72.
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  198. Milner JL, Silo-Suh L, Lee JC, He H, Clardy J, Handelsman J. Production of kanosamine by Bacillus cereus UW85. Appl Environ Microbiol. 1996 Aug; 62(8):3061-5.
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  199. Choi J, Chen J, Schreiber SL, Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 1996 Jul 12; 273(5272):239-42.
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  200. Lee JC, Coval SJ, Clardy J. A cholesteryl ester transfer protein inhibitor from an insect-associated fungus. J Antibiot (Tokyo). 1996 Jul; 49(7):693-6.
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  201. Zhang S, Kongsaeree P, Clardy J, Wilson DB, Ganem B. Site-directed mutagenesis of monofunctional chorismate mutase engineered from the E. coli P-protein. Bioorg Med Chem. 1996 Jul; 4(7):1015-20.
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  202. Ganesh V, Lee AY, Clardy J, Tulinsky A. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin. Protein Sci. 1996 May; 5(5):825-35.
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  203. Liang J, Chen JK, Schreiber ST, Clardy J. Crystal structure of P13K SH3 domain at 20 angstroms resolution. J Mol Biol. 1996 Apr 5; 257(3):632-43.
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  204. Kirst HA, Mynderse JS, Martin JW, Baker PJ, Paschal JW, Rios Steiner JL, Lobkovsky E, Clardy J. Structure of the spiroketal-macrolide ossamycin. J Antibiot (Tokyo). 1996 Feb; 49(2):162-7.
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  205. Liang J, Ealick S, Nielsen C, Schreiber SL, Clardy J. Crystallization and preliminary X-ray analysis of twinned crystals of a chimeric FK506 binding protein 12 and 13 complexed with FK506. Acta Crystallogr D Biol Crystallogr. 1996 Jan 1; 52(Pt 1):207-10.
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  206. Lee JC, Yang X, Schwartz M, Strobel G, Clardy J. The relationship between an endangered North American tree and an endophytic fungus. Chem Biol. 1995 Nov; 2(11):721-7.
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  207. Concepción GP, Foderaro TA, Eldredge GS, Lobkovsky E, Clardy J, Barrows LR, Ireland CM. Topoisomerase II-mediated DNA cleavage by adocia- and xestoquinones from the Philippine sponge Xestospongia sp. J Med Chem. 1995 Oct 27; 38(22):4503-7.
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  208. Kirst HA, Larsen SH, Paschal JW, Occolowitz JL, Creemer LC, Steiner JL, Lobkovsky E, Clardy J. Structure of the new spiroketal-macrolide A82548A. J Antibiot (Tokyo). 1995 Sep; 48(9):990-6.
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  209. Lee AY, Stewart JD, Clardy J, Ganem B. New insight into the catalytic mechanism of chorismate mutases from structural studies. Chem Biol. 1995 Apr; 2(4):195-203.
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  210. Clardy J. The chemistry of signal transduction. Proc Natl Acad Sci U S A. 1995 Jan 3; 92(1):56-61.
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  211. Fuller RW, Cardellina JH, Jurek J, Scheuer PJ, Alvarado-Lindner B, McGuire M, Gray GN, Steiner JR, Clardy J, Menez E, et al. Isolation and structure/activity features of halomon-related antitumor monoterpenes from the red alga Portieria hornemannii. J Med Chem. 1994 Dec 9; 37(25):4407-11.
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  212. Lee AY, Smitka TA, Bonjouklian R, Clardy J. Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function. Chem Biol. 1994 Oct; 1(2):113-7.
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  213. Silo-Suh LA, Lethbridge BJ, Raffel SJ, He H, Clardy J, Handelsman J. Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85. Appl Environ Microbiol. 1994 Jun; 60(6):2023-30.
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  214. Pcolinski MJ, Doskotch RW, Lee AY, Clardy J. Chlorosilphanol A and silphanepoxol, labdane diterpenes from Silphium perfoliatum. J Nat Prod. 1994 Jun; 57(6):776-83.
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  215. Miles DH, Tunsuwan K, Chittawong V, Hedin PA, Kokpol U, Ni CZ, Clardy J. Agrochemical activity and isolation of N-(4'-bromophenyl)-2,2-diphenylacetanilide from the Thai plant Arundo donax. J Nat Prod. 1993 Sep; 56(9):1590-3.
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  216. Clardy J. Structural studies of complexed FK-506 binding protein. Ann N Y Acad Sci. 1993 Jun 23; 685:37-45.
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  217. Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J. Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. J Mol Biol. 1993 Jan 5; 229(1):105-24.
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  218. Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM, Boyd MR. A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. J Med Chem. 1992 Aug 7; 35(16):3007-11.
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  219. Ayer WA, Sun M, Browne LM, Brinen LS, Clardy J. Chemical investigation of the metabolites from the Canadian tuckahoe, Polyporus tuberaster. J Nat Prod. 1992 May; 55(5):649-53.
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  220. Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J. Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex. Science. 1991 May 10; 252(5007):839-42.
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  221. A diterpenoid lactone from Aplysia juliana. J Nat Prod. 1991 May-Jun; 54(3):886-8.
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  222. Powell RG, Mikolajczak KL, Zilkowski BW, Mantus EK, Cherry D, Clardy J. Limonoid antifeedants from seed of Sandoricum koetjape. J Nat Prod. 1991 Jan-Feb; 54(1):241-6.
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  223. LaLonde RT, Perakyla H, Ishiguro Y, Clardy J, Brinen LS. Structure of an anhydride related to a mutagenic component of drinking water, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. Chem Res Toxicol. 1990 Sep-Oct; 3(5):404-5.
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  224. Ahmad VU, Choudhary MI, Akhtar MF, Ahmed M, Rizwani GH, Usmanghani K, Clardy J. 2-O-alpha-D-galactopyranosyl glycerol hexaacetate from Ruellia brittoniana. J Nat Prod. 1990 Jul-Aug; 53(4):960-3.
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  225. Nishio M, Tomatsu K, Konishi M, Tomita K, Oki T, Kawaguchi H, Clardy J. Karnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties. J Antibiot (Tokyo). 1989 Jun; 42(6):852-68.
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  226. Lin LZ, Cordell GA, Ni CZ, Clardy J. New humantenine-type alkaloids from Gelsemium elegans. J Nat Prod. 1989 May-Jun; 52(3):588-94.
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  227. Kernan MR, Faulkner DJ, Parkanyi L, Clardy J, de Carvalho MS, Jacobs RS. Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp.. Experientia. 1989 Apr 15; 45(4):388-90.
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  228. Mikolajczak KL, Weisleder D, Parkanyi L, Clardy J. A limonoid antifeedant from seed of Carapa procera. J Nat Prod. 1988 May-Jun; 51(3):606-10.
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  229. Wilcox CF, Blain DA, Clardy J, Van Duyne G, Gleiter R, Eckert-Maksic M. 3H-Cyclonona[def]biphenylene. An example of neutral homoantiaromaticity. J Am Chem Soc. 1986 Nov 1; 108(24):7693-702.
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  230. McMurry JE, Haley GJ, Matz JR, Clardy JC, Mitchell J. Pentacyclo[12.2.2.22,5.26,9.210,13]-1,5,9,13-tetracosatetraene and its reaction with silver trifluoromethanesulfonate. Synthesis of a square-planar d10 organometallic complex. J Am Chem Soc. 1986 Feb 1; 108(3):515-6.
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  231. Shimizu Y, Chou HN, Bando H, Van Duyne G, Clardy J. Structure of brevetoxin A (GB-1 toxin), the most potent toxin in the Florida red tide organism Gymnodinium breve (Ptychodiscus brevis). J Am Chem Soc. 1986 Feb 1; 108(3):514-5.
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  232. Sugawara F, Strobel G, Fisher LE, Van Duyne GD, Clardy J. Bipolaroxin, a selective phytotoxin produced by Bipolaris cynodontis. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8291-4.
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  233. Kaiser C, Dandridge PA, Garvey E, Hahn RA, Sarau HM, Setler PE, Bass LS, Clardy J. Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine. J Med Chem. 1982 Jun; 25(6):697-703.
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  234. Balitz DM, O'Herron FA, Bush J, Vyas DM, Nettleton DE, Grulich RE, Bradner WT, Doyle TW, Arnold E, Clardy J. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. J Antibiot (Tokyo). 1981 Dec; 34(12):1544-55.
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  235. Grieco PA, Owens W, Wang CL, Williams E, Schillinger WJ, Hirotsu K, Clardy J. Fluoroprostaglandins: synthesis and biological evaluation of the methyl esters of (+)-12-fluoro-, (-)-ent-12-fluoro-, (+)-15-epi-fluoro-, and (-)-ent-15 epi-12-fluoroprostaglandin F2 alpha. J Med Chem. 1980 Oct; 23(10):1072-7.
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  236. Howard BM, Fenical W, Finer J, Hirotsu K, Clardy J. Neoconcinndiol hydroperoxide, a novel marine diterpenoid from the red alga Laurencia. J Am Chem Soc. 1977 Sep 14; 99(19):6440-1.
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  237. Sun HH, Waraszkiewicz SM, Erickson KL, Finer KL, Clardy J. Dictyoxepin and dictyolene, two new diterpenes from the marine alga Dictyota acutiloba (Phaeophyta) J Am Chem Soc. 1977 May 11; 99(10):3516-7.
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  238. Wratten SJ, Faulkner DJ, Hirotsu K, Clardy J. Trimethylenemethane. A reversible, temperature dependent transformation from higher to lower symmetry as observed by electron spin resonance spectroscopy. J Am Chem Soc. 1977 Apr 13; 99(8):2824-5.
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  239. Chexal KK, Spinger JP, Clardy J, Cole RJ, Kirksey JW, Dorner JW, Cutler HG, Strawter BJ. Austin, a novel polyisoprenoid mycotoxin from Aspergillus ustus. J Am Chem Soc. 1976 Oct 13; 98(21):6748.
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  240. Prestwich GD, Tanis SP, Springer JP, Clardy J. Letter: Nasute termite soldier frontal gland secretions. 1. Structure of trinervi-2 beta, 3 alpha, 9 alpha-triol 9-o-acetate, a novel diterpene fromTrinervitermes soldiers. J Am Chem Soc. 1976 Sep 15; 98(19):6061-2.
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  241. Ireland C, Faulkner DJ, Finer J, Clardy J. Letter: A novel diterpene from Dollabella californica. J Am Chem Soc. 1976 Jul 21; 98(15):4664-5.
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  242. Macmillan JG, Springer JP, Clardy J, Cole RJ, Kirksey JW. Letter: Structure and synthesis of verruculotoxin, a new mycotoxin from Penicillium verruculosum Peyronel. J Am Chem Soc. 1976 Jan 7; 98(1):246-7.
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  243. Pezzanite JO, Clardy J, Lau PY, Wood G, Walker DL, Fraser-Reid B. Letter: A revised structure for the antibiotic pillaromycin A. J Am Chem Soc. 1975 Oct 15; 97(21):6250-1.
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  244. Schantz EJ, Ghazarossian VE, Schnoes HK, Strong FM, Springer JP, Pezzanite JO, Clardy J. Letter: The structure of saxitoxin. J Am Chem Soc. 1975 Mar 5; 97(5):1238.
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  245. Clardy J, Springer JP, Buchi G, Matsuo K, Wightman R. Letter: Tryptoquivaline and tryptoquivalone, two tremorgenic metabolites of aspergillus clavatus. J Am Chem Soc. 1975 Feb 5; 97(3):663-5.
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  246. Anderson GD, Powers TJ, Djerassi C, Fayos J, Clardy J. A stereoselective synthesis of two stereoisomers of demethylgorgosterol. J Am Chem Soc. 1975 Jan 22; 97(2):388-94.
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  247. Fayos J, Lokensgard D, Clardy J, Cole RJ, Kirksey JW. Letter: Structure of verruculogen, a tremor producing peroxide from Penicillium verruculosum. J Am Chem Soc. 1974 Oct 16; 96(21):6785-7.
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  248. Boeckman RK, Fayos J, Clardy J. Letter: A revised structure of vermiculine. A novel macrolide dilactone antibiotic from Penicillium vermiculatum. J Am Chem Soc. 1974 Sep 4; 96(18):5954-6.
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  249. Swenton JS, Hyatt JA, Lisy JM, Clardy J. Photochemical cycloadditions of triplet 1,3-dimethyluracil to olefins. Structural studies on the adducts. J Am Chem Soc. 1974 Jul 24; 96(15):4885-91.
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  250. Springer JP, Clardy J, Cole RJ, Kirksey JW, Hill RK, Carlson MR, Isidor JL. Structure and synthesis of moniliformin, a novel cyclobutane microbial toxin. J Am Chem Soc. 1974 Apr 3; 96(7):2267-8.
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  251. Hall SS, Faulkner DJ, Fayos J, Clardy J. Oppositol, a brominated sesquiterpene alcohol of a new skeletal class from the red alga, Laurencia subopposita. J Am Chem Soc. 1973 Oct 17; 95(21):7187-9.
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  252. Büchi G, Kitaura Y, Yuan SS, Wright HE, Clardy J, Demain AL, Ginsukon T, Hunt N, Wogan GN. Letter: structure of cytochalasin E, a toxic metabolite of Aspergillus clavatus. J Am Chem Soc. 1973 Aug 8; 95(16):5423-5.
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