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Joseph Raffetto, M.D.

TitleAssistant Professor of Surgery
InstitutionBrigham and Women's Hospital
DepartmentSurgery
AddressBoston Va Med Ctr-W Roxbury
Surgery 112
1400 VFW Pkwy
West Roxbury MA 02132
Phone857/203-6200

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Raffetto JD. Commentary on: 'In vitro identification of distinctive metabolic signatures of intact varicose vein tissue via magic angle spinning nuclear magnetic resonance spectroscopy'. Eur J Vasc Endovasc Surg. 2012 Oct; 44(4):451.
    View in: PubMed
  2. Reslan OM, Ebaugh JL, Gupta N, Brecher SM, Itani KM, Raffetto JD. Acute expansion of a hospital-acquired methicillin-resistant Staphylococcus aureus-infected abdominal aortic aneurysm. Ann Vasc Surg. 2012 Jul; 26(5):732.e1-6.
    View in: PubMed
  3. Meissner MH, Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Lohr JM, McLafferty RB, Murad MH, Padberg F, Pappas P, Raffetto JD, Wakefield TW. Early thrombus removal strategies for acute deep venous thrombosis: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2012 May; 55(5):1449-62.
    View in: PubMed
  4. Raffetto JD, Yu P, Reslan OM, Xia Y, Khalil RA. Endothelium-dependent nitric oxide and hyperpolarization-mediated venous relaxation pathways in rat inferior vena cava. J Vasc Surg. 2012 Jun; 55(6):1716-25.
    View in: PubMed
  5. Ebaugh JL, Gupta N, Raffetto JD. Single-incision external iliac artery endarterectomy and patch angioplasty. Ann Vasc Surg. 2011 Nov; 25(8):1165-9.
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  6. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H1862-71.
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  7. Raffetto JD. Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. Phlebology. 2011 Jun; 26(4):133-4.
    View in: PubMed
  8. Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Gloviczki ML, Lohr JM, McLafferty RB, Meissner MH, Murad MH, Padberg FT, Pappas PJ, Passman MA, Raffetto JD, Vasquez MA, Wakefield TW. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011 May; 53(5 Suppl):2S-48S.
    View in: PubMed
  9. Raffetto JD, Khalil RA. Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins. J Vasc Surg. 2011 Aug; 54(2):489-96.
    View in: PubMed
  10. Ebaugh JL, Yuan M, Hu J, Chen A, Raffetto JD. Intimal sarcoma of the superficial femoral artery with osteosarcomatous differentiation. J Vasc Surg. 2011 May; 53(5):1394-7.
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  11. Raffetto JD, Marston WA. Venous ulcer: what is new? Plast Reconstr Surg. 2011 Jan; 127 Suppl 1:279S-288S.
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  12. Mannello F, Raffetto JD. Matrix metalloproteinase activity and glycosaminoglycans in chronic venous disease: the linkage among cell biology, pathology and translational research. Am J Transl Res. 2011 Feb; 3(2):149-58.
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  13. Lim CS, Qiao X, Reslan OM, Xia Y, Raffetto JD, Paleolog E, Davies AH, Khalil RA. Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava. J Vasc Surg. 2011 Mar; 53(3):764-73.
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  14. Raffetto JD. The definition of the venous ulcer. J Vasc Surg. 2010 Nov; 52(5 Suppl):46S-49S.
    View in: PubMed
  15. Reslan OM, Ebaugh JL, Raffetto JD. Bilateral asymptomatic extracranial carotid artery aneurysms. Ann Vasc Surg. 2010 Jul; 24(5):691.e11-6.
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  16. Raffetto JD, Qiao X, Beauregard KG, Khalil RA. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg. 2010 Apr; 51(4):972-81.
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  17. Raffetto JD, Qiao X, Beauregard KG, Tanbe AF, Kumar A, Mam V, Khalil RA. Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins. J Vasc Surg. 2010 Apr; 51(4):962-71.
    View in: PubMed
  18. Owens CD, Kim JM, Hevelone ND, Hamdan A, Raffetto JD, Creager MA, Conte MS. Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous vein. J Vasc Surg. 2010 May; 51(5):1152-9.
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  19. Ebaugh JL, Raffetto JD. Images in clinical medicine. Giant abdominal aortic aneurysm. N Engl J Med. 2010 Jan 7; 362(1):66.
    View in: PubMed
  20. Raffetto JD. Dermal pathology, cellular biology, and inflammation in chronic venous disease. Thromb Res. 2009; 123 Suppl 4:S66-71.
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  21. Ebaugh JL, Gagnon D, Owens CD, Conte MS, Raffetto JD. Comparison of costs of staged versus simultaneous lower extremity arterial hybrid procedures. Am J Surg. 2008 Nov; 196(5):634-40.
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  22. Raffetto JD, Barros YV, Wells AK, Khalil RA. MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. J Surg Res. 2010 Apr; 159(2):755-64.
    View in: PubMed
  23. Raffetto JD, Khalil RA. Matrix metalloproteinases in venous tissue remodeling and varicose vein formation. Curr Vasc Pharmacol. 2008 Jul; 6(3):158-72.
    View in: PubMed
  24. Raffetto JD, Gram CH, Overman KC, Menzoian JO. Mitogen-activated protein kinase p38 pathway in venous ulcer fibroblasts. Vasc Endovascular Surg. 2008 Aug-Sep; 42(4):367-74.
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  25. Raffetto JD, Qiao X, Koledova VV, Khalil RA. Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins. J Vasc Surg. 2008 Aug; 48(2):447-56.
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  26. Grochow RM, Raffetto JD. Chronic traumatic pseudoaneurysm of polytetrafluoroethylene axillofemoral bypass graft in a quadriplegic patient. Ann Vasc Surg. 2008 Sep; 22(5):688-91.
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  27. Pojoga LH, Yao TM, Sinha S, Ross RL, Lin JC, Raffetto JD, Adler GK, Williams GH, Khalil RA. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1258-65.
    View in: PubMed
  28. Raffetto JD, Khalil RA. Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology. 2008; 23(2):85-98.
    View in: PubMed
  29. Huang AL, Silver AE, Shvenke E, Schopfer DW, Jahangir E, Titas MA, Shpilman A, Menzoian JO, Watkins MT, Raffetto JD, Gibbons G, Woodson J, Shaw PM, Dhadly M, Eberhardt RT, Keaney JF, Gokce N, Vita JA. Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery. Arterioscler Thromb Vasc Biol. 2007 Oct; 27(10):2113-9.
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  30. Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol. 2008 Jan 15; 75(2):346-59.
    View in: PubMed
  31. Raffetto JD, Ross RL, Khalil RA. Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation. J Vasc Surg. 2007 Feb; 45(2):373-80.
    View in: PubMed
  32. Seidman C, Raffetto JD, Overman KC, Menzoian JO. Venous ulcer fibroblasts respond to basic fibroblast growth factor at the cell cycle protein level. Ann Vasc Surg. 2006 May; 20(3):376-80.
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  33. Raffetto JD, Vasquez R, Goodwin DG, Menzoian JO. Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts. Vasc Endovascular Surg. 2006 Jan-Feb; 40(1):59-66.
    View in: PubMed
  34. Raffetto JD, Montgomery JE, Eberhardt RT, LaMorte WW, Menzoian JO. Differences in risk factors for lower extremity arterial occlusive disease. J Am Coll Surg. 2005 Dec; 201(6):918-24.
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  35. Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation. 2005 May 10; 111(18):2398-409.
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  36. Raffetto JD, Bernardo J, Menzoían JO. Aortobifemoral graft infection with Mycobacterium tuberculosis: treatment with abscess drainage, debridement, and long-term administration of antibiotic agents. J Vasc Surg. 2004 Oct; 40(4):826-9.
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  37. Vasquez R, Marien BJ, Gram C, Goodwin DG, Menzoian JO, Raffetto JD. Proliferative capacity of venous ulcer wound fibroblasts in the presence of platelet-derived growth factor. Vasc Endovascular Surg. 2004 Jul-Aug; 38(4):355-60.
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  38. Yu NR, Eberhardt RT, Menzoian JO, Urick CL, Raffetto JD. Vertebral artery dissection following intravascular catheter placement: a case report and review of the literature. Vasc Med. 2004 May; 9(3):199-203.
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  39. Minor ME, Menzoian JO, Raffetto JD. Noninfectious saccular abdominal aortic aneurysm--a report of two cases. Vasc Endovascular Surg. 2003 Sep-Oct; 37(5):353-8.
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  40. Raffetto JD, Cheung Y, Fisher JB, Cantelmo NL, Watkins MT, Lamorte WW, Menzoian JO. Incision and abdominal wall hernias in patients with aneurysm or occlusive aortic disease. J Vasc Surg. 2003 Jun; 37(6):1150-4.
    View in: PubMed
  41. Seidman C, Raffetto JD, Marien B, Kroon C, Seah CC, Menzoian JO. bFGF-induced alterations in cellular markers of senescence in growth-rescued fibroblasts from chronic venous ulcer and venous reflux patients. Ann Vasc Surg. 2003 May; 17(3):239-44.
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  42. Lemos DW, Raffetto JD, Moore TC, Menzoian JO. Primary aortoduodenal fistula: a case report and review of the literature. J Vasc Surg. 2003 Mar; 37(3):686-9.
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  43. Suliman AS, Raffetto JD, Seidman CS, Menzoian JO. Acute thrombosis of abdominal aortic aneurysms--report of two cases and review of the literature. Vasc Endovascular Surg. 2003 Jan-Feb; 37(1):71-5.
    View in: PubMed
  44. Marien BJ, Raffetto JD, Seidman CS, LaMorte WW, Menzoian JO. Bovine pericardium vs dacron for patch angioplasty after carotid endarterectomy: a prospective randomized study. Arch Surg. 2002 Jul; 137(7):785-8.
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  45. Raffetto JD, Chen MN, LaMorte WW, Seidman CS, Eberhardt RT, Woodson J, Gibbons GW, Menzoian JO. Factors that predict site of outflow target artery anastomosis in infrainguinal revascularization. J Vasc Surg. 2002 Jun; 35(6):1093-9.
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  46. Raffetto JD, Leverkus M, Park HY, Menzoian JO. Synopsis on cellular senescence and apoptosis. J Vasc Surg. 2001 Jul; 34(1):173-7.
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  47. Raffetto JD, Mendez MV, Marien BJ, Byers HR, Phillips TJ, Park HY, Menzoian JO. Changes in cellular motility and cytoskeletal actin in fibroblasts from patients with chronic venous insufficiency and in neonatal fibroblasts in the presence of chronic wound fluid. J Vasc Surg. 2001 Jun; 33(6):1233-41.
    View in: PubMed
  48. Mendez MV, Raffetto JD, Phillips T, Menzoian JO, Park HY. The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer wound fluid: A potential mechanism for senescence in venous ulcers. J Vasc Surg. 1999 Oct; 30(4):734-43.
    View in: PubMed
  49. Raffetto JD, Mendez MV, Phillips TJ, Park HY, Menzoian JO. The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiency with and without ulcer. Am J Surg. 1999 Aug; 178(2):107-12.
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  50. Volpe CM, Raffetto JD, Collure DW, Hoover EL, Doerr RJ. Unilateral male breast masses: cancer risk and their evaluation and management. Am Surg. 1999 Mar; 65(3):250-3.
    View in: PubMed
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