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Sean P.J. Whelan, Ph.D.

TitleProfessor of Microbiology and Immunobiology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Medical School
MBIB, Room 940 E
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-1923
Fax617/738-7664

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Whelan SP, Carchman EH, Kautza B, Nassour I, Mollen K, Escobar D, Gomez H, Rosengart MA, Shiva S, Zuckerbraun BS. Polymicrobial sepsis is associated with decreased hepatic oxidative phosphorylation and an altered metabolic profile. J Surg Res. 2014 Jan; 186(1):297-303.
    View in: PubMed
  2. Carchman EH, Whelan S, Loughran P, Mollen K, Stratamirovic S, Shiva S, Rosengart MR, Zuckerbraun BS. Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver. FASEB J. 2013 Dec; 27(12):4703-11.
    View in: PubMed
  3. Piccinotti S, Kirchhausen T, Whelan SP. Uptake of Rabies Virus into Epithelial Cells by Clathrin-Mediated Endocytosis Depends upon Actin. J Virol. 2013 Nov; 87(21):11637-47.
    View in: PubMed
  4. Whelan SP, Zuckerbraun BS. Mitochondrial signaling: forwards, backwards, and in between. Oxid Med Cell Longev. 2013; 2013:351613.
    View in: PubMed
  5. Morin B, Kranzusch PJ, Rahmeh AA, Whelan SP. The polymerase of negative-stranded RNA viruses. Curr Opin Virol. 2013 Apr; 3(2):103-10.
    View in: PubMed
  6. Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Wessels MW, Lefeber DJ, Whelan SP, van Bokhoven H, Brummelkamp TR. Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry. Science. 2013 Apr 26; 340(6131):479-83.
    View in: PubMed
  7. Ivanovic T, Choi JL, Whelan SP, van Oijen AM, Harrison SC. Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. Elife. 2013; 2:e00333.
    View in: PubMed
  8. Semler BL, Whelan SP. Methods to study RNA virus molecular biology. Methods. 2013 Feb; 59(2):165-6.
    View in: PubMed
  9. Lee AS, Burdeinick-Kerr R, Whelan SP. A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs. Proc Natl Acad Sci U S A. 2013 Jan 2; 110(1):324-9.
    View in: PubMed
  10. Krishnan A, Miller EH, Herbert AS, Ng M, Ndungo E, Whelan SP, Dye JM, Chandran K. Niemann-Pick C1 (NPC1)/NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor. Viruses. 2012; 4(11):2471-84.
    View in: PubMed
  11. Rahmeh AA, Morin B, Schenk AD, Liang B, Heinrich BS, Brusic V, Walz T, Whelan SP. Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus. Proc Natl Acad Sci U S A. 2012 Sep 4; 109(36):14628-33.
    View in: PubMed
  12. Kranzusch PJ, Whelan SP. Architecture and regulation of negative-strand viral enzymatic machinery. RNA Biol. 2012 Jul 1; 9(7):941-8.
    View in: PubMed
  13. Heinrich BS, Morin B, Rahmeh AA, Whelan SP. Structural properties of the C terminus of vesicular stomatitis virus N protein dictate N-RNA complex assembly, encapsidation, and RNA synthesis. J Virol. 2012 Aug; 86(16):8720-9.
    View in: PubMed
  14. Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K. Ebola virus entry requires the host-programmed recognition of an intracellular receptor. EMBO J. 2012 Apr 18; 31(8):1947-60.
    View in: PubMed
  15. Morin B, Rahmeh AA, Whelan SP. Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase. EMBO J. 2012 Mar 7; 31(5):1320-9.
    View in: PubMed
  16. Kranzusch PJ, Whelan SP. Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex. Proc Natl Acad Sci U S A. 2011 Dec 6; 108(49):19743-8.
    View in: PubMed
  17. Cureton DK, Burdeinick-Kerr R, Whelan SP. Genetic inactivation of COPI coatomer separately inhibits vesicular stomatitis virus entry and gene expression. J Virol. 2012 Jan; 86(2):655-66.
    View in: PubMed
  18. Mulherkar N, Raaben M, de la Torre JC, Whelan SP, Chandran K. The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway. Virology. 2011 Oct 25; 419(2):72-83.
    View in: PubMed
  19. Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature. 2011 Sep 15; 477(7364):340-3.
    View in: PubMed
  20. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15414-9.
    View in: PubMed
  21. Stanifer ML, Cureton DK, Whelan SP. A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion. J Virol. 2011 Aug; 85(16):8105-15.
    View in: PubMed
  22. Tekes G, Rahmeh AA, Whelan SP. A freeze frame view of vesicular stomatitis virus transcription defines a minimal length of RNA for 5' processing. PLoS Pathog. 2011 Jun; 7(6):e1002073.
    View in: PubMed
  23. Rahmeh AA, Schenk AD, Danek EI, Kranzusch PJ, Liang B, Walz T, Whelan SP. Molecular architecture of the vesicular stomatitis virus RNA polymerase. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20075-80.
    View in: PubMed
  24. Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP. Assembly of a functional Machupo virus polymerase complex. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20069-74.
    View in: PubMed
  25. Cureton DK, Massol RH, Whelan SP, Kirchhausen T. The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis. PLoS Pathog. 2010; 6(9):e1001127.
    View in: PubMed
  26. Radoshitzky SR, Dong L, Chi X, Clester JC, Retterer C, Spurgers K, Kuhn JH, Sandwick S, Ruthel G, Kota K, Boltz D, Warren T, Kranzusch PJ, Whelan SP, Bavari S. Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin. J Virol. 2010 Oct; 84(20):10569-80.
    View in: PubMed
  27. Heinrich BS, Cureton DK, Rahmeh AA, Whelan SP. Protein expression redirects vesicular stomatitis virus RNA synthesis to cytoplasmic inclusions. PLoS Pathog. 2010; 6(6):e1000958.
    View in: PubMed
  28. Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan SP, Guidotti LG, von Andrian UH. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature. 2010 Jun 24; 465(7301):1079-83.
    View in: PubMed
  29. Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 2010 May 14; 141(4):668-81.
    View in: PubMed
  30. Wolf MC, Freiberg AN, Zhang T, Akyol-Ataman Z, Grock A, Hong PW, Li J, Watson NF, Fang AQ, Aguilar HC, Porotto M, Honko AN, Damoiseaux R, Miller JP, Woodson SE, Chantasirivisal S, Fontanes V, Negrete OA, Krogstad P, Dasgupta A, Moscona A, Hensley LE, Whelan SP, Faull KF, Holbrook MR, Jung ME, Lee B. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3157-62.
    View in: PubMed
  31. Wong AC, Sandesara RG, Mulherkar N, Whelan SP, Chandran K. A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry. J Virol. 2010 Jan; 84(1):163-75.
    View in: PubMed
  32. Rahmeh AA, Li J, Kranzusch PJ, Whelan SP. Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein. J Virol. 2009 Nov; 83(21):11043-50.
    View in: PubMed
  33. Cureton DK, Massol RH, Saffarian S, Kirchhausen TL, Whelan SP. Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog. 2009 Apr; 5(4):e1000394.
    View in: PubMed
  34. Li J, Rahmeh A, Brusic V, Whelan SP. Opposing effects of inhibiting cap addition and cap methylation on polyadenylation during vesicular stomatitis virus mRNA synthesis. J Virol. 2009 Feb; 83(4):1930-40.
    View in: PubMed
  35. Whelan SP. Response to "Non-segmented negative-strand RNA virus RNA synthesis in vivo". Virology. 2008 Feb 20; 371(2):234-7.
    View in: PubMed
  36. Li J, Rahmeh A, Morelli M, Whelan SP. A conserved motif in region v of the large polymerase proteins of nonsegmented negative-sense RNA viruses that is essential for mRNA capping. J Virol. 2008 Jan; 82(2):775-84.
    View in: PubMed
  37. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 1; 450(7166):110-4.
    View in: PubMed
  38. Wang JT, McElvain LE, Whelan SP. Vesicular stomatitis virus mRNA capping machinery requires specific cis-acting signals in the RNA. J Virol. 2007 Oct; 81(20):11499-506.
    View in: PubMed
  39. Li J, Chorba JS, Whelan SP. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007 Apr; 81(8):4104-15.
    View in: PubMed
  40. Li J, Wang JT, Whelan SP. A unique strategy for mRNA cap methylation used by vesicular stomatitis virus. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8493-8.
    View in: PubMed
  41. Robinson CD, Lourido S, Whelan SP, Dudycha JL, Lynch M, Isern S. Viral transgenesis of embryonic cell cultures from the freshwater microcrustacean Daphnia. J Exp Zool A Comp Exp Biol. 2006 Jan 1; 305(1):62-7.
    View in: PubMed
  42. Schott DH, Cureton DK, Whelan SP, Hunter CP. An antiviral role for the RNA interference machinery in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18420-4.
    View in: PubMed
  43. Li J, Fontaine-Rodriguez EC, Whelan SP. Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity. J Virol. 2005 Nov; 79(21):13373-84.
    View in: PubMed
  44. Chandran K, Sullivan NJ, Felbor U, Whelan SP, Cunningham JM. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science. 2005 Jun 10; 308(5728):1643-5.
    View in: PubMed
  45. Cherry S, Doukas T, Armknecht S, Whelan S, Wang H, Sarnow P, Perrimon N. Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev. 2005 Feb 15; 19(4):445-52.
    View in: PubMed
  46. Whelan SP, Barr JN, Wertz GW. Transcription and replication of nonsegmented negative-strand RNA viruses. Curr Top Microbiol Immunol. 2004; 283:61-119.
    View in: PubMed
  47. Barr JN, Whelan SP, Wertz GW. Transcriptional control of the RNA-dependent RNA polymerase of vesicular stomatitis virus. Biochim Biophys Acta. 2002 Sep 13; 1577(2):337-53.
    View in: PubMed
  48. Whelan SP, Wertz GW. Transcription and replication initiate at separate sites on the vesicular stomatitis virus genome. Proc Natl Acad Sci U S A. 2002 Jul 9; 99(14):9178-83.
    View in: PubMed
  49. Whelan SP, Barr JN, Wertz GW. Identification of a minimal size requirement for termination of vesicular stomatitis virus mRNA: implications for the mechanism of transcription. J Virol. 2000 Sep; 74(18):8268-76.
    View in: PubMed
  50. Whelan SP, Wertz GW. Regulation of RNA synthesis by the genomic termini of vesicular stomatitis virus: identification of distinct sequences essential for transcription but not replication. J Virol. 1999 Jan; 73(1):297-306.
    View in: PubMed
  51. Whelan SP, Wertz GW. The 5' terminal trailer region of vesicular stomatitis virus contains a position-dependent cis-acting signal for assembly of RNA into infectious particles. J Virol. 1999 Jan; 73(1):307-15.
    View in: PubMed
  52. Wertz GW, Yu Q, Ball A, Barr JN, Whelan SPJ. Gene Therapy Vectors and Vaccines Based on Non-segmented Negative-Stranded RNA Viruses. 1998.
  53. Barr JN, Whelan SP, Wertz GW. cis-Acting signals involved in termination of vesicular stomatitis virus mRNA synthesis include the conserved AUAC and the U7 signal for polyadenylation. J Virol. 1997 Nov; 71(11):8718-25.
    View in: PubMed
  54. Barr JN, Whelan SP, Wertz GW. Role of the intergenic dinucleotide in vesicular stomatitis virus RNA transcription. J Virol. 1997 Mar; 71(3):1794-801.
    View in: PubMed
  55. Whelan SPJ, Wertz GW. VSV Genomic Termini; Identification of cis-acting signals that control replication and assembly. "Viral Genome Replication". 1996.
  56. Wertz GW, Whelan SPJ, Ball A, Barr J. Recovery of infectious VSV from cDNA clones: cis-acting elements involved in control of RNA replication and assembly of replicated RNA into infectious particles. "Viral Genome Replication". 1996.
  57. Whelan SP, Ball LA, Barr JN, Wertz GT. Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8388-92.
    View in: PubMed
  58. Whelan SP, Evans D, Almond JW. Manipulation of the cellular binding properties of poliovirus: implications for non-target effects of recombinant vaccines. Dev Biol Stand. 1995; 84:129-36.
    View in: PubMed
  59. Wertz GW, Whelan S, LeGrone A, Ball LA. Extent of terminal complementarity modulates the balance between transcription and replication of vesicular stomatitis virus RNA. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8587-91.
    View in: PubMed
  60. Wertz GW, Whelan SPJ, Ball LA. VSV: Requirements for RNA encapsidation, replication, assembly and budding of infectious particles. 1994.
  61. Whelan SPJ, Wertz GW. Defining the cis-acting elements that mediate replication and budding of VSV RNA. 1994.
  62. Whelan SPJ. Alteration of the cellular binding characteristics of poliovirus. 1993.
  63. Whelan SPJ, Almond JW. Poliovirus chimeras expressing novel protein binding motifs. Cell biology of virus entry, replication, and pathogenesis. 1992.
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