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Johan Paulsson, PH.D.

TitleProfessor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology - Alpert 536
200 Longwood Ave
Boston MA 02115
Phone617/432-5730

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Norman TM, Lord ND, Paulsson J, Losick R. Memory and modularity in cell-fate decision making. Nature. 2013 Nov 28; 503(7477):481-6.
    View in: PubMed
  2. Lau BT, Malkus P, Paulsson J. New quantitative methods for measuring plasmid loss rates reveal unexpected stability. Plasmid. 2013 Nov; 70(3):353-61.
    View in: PubMed
  3. Toprak E, Veres A, Yildiz S, Pedraza JM, Chait R, Paulsson J, Kishony R. Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nat Protoc. 2013 Feb 21; 8(3):555-67.
    View in: PubMed
  4. Hilfinger A, Chen M, Paulsson J. Using temporal correlations and full distributions to separate intrinsic and extrinsic fluctuations in biological systems. Phys Rev Lett. 2012 Dec 14; 109(24):248104.
    View in: PubMed
  5. Landgraf D, Okumus B, Chien P, Baker TA, Paulsson J. Segregation of molecules at cell division reveals native protein localization. Nat Methods. 2012 May; 9(5):480-2.
    View in: PubMed
  6. Tal S, Paulsson J. Evaluating quantitative methods for measuring plasmid copy numbers in single cells. Plasmid. 2012 Mar; 67(2):167-73.
    View in: PubMed
  7. Huh D, Paulsson J. Random partitioning of molecules at cell division. Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36):15004-9.
    View in: PubMed
  8. Hilfinger A, Paulsson J. Separating intrinsic from extrinsic fluctuations in dynamic biological systems. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12167-72.
    View in: PubMed
  9. Huh D, Paulsson J. Non-genetic heterogeneity from stochastic partitioning at cell division. Nat Genet. 2011 Feb; 43(2):95-100.
    View in: PubMed
  10. Lestas I, Vinnicombe G, Paulsson J. Fundamental limits on the suppression of molecular fluctuations. Nature. 2010 Sep 9; 467(7312):174-8.
    View in: PubMed
  11. Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44):18563-8.
    View in: PubMed
  12. Pedraza JM, Paulsson J. Effects of molecular memory and bursting on fluctuations in gene expression. Science. 2008 Jan 18; 319(5861):339-43.
    View in: PubMed
  13. Paulsson JF, Schultz SW, Köhler M, Leibiger I, Berggren PO, Westermark GT. Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation. Exp Diabetes Res. 2008; 2008:865850.
    View in: PubMed
  14. Pedraza JM, Paulsson J. Random timing in signaling cascades. Mol Syst Biol. 2007; 3:81.
    View in: PubMed
  15. Rando OJ, Paulsson J. Noisy silencing of chromatin. Dev Cell. 2006 Aug; 11(2):134-6.
    View in: PubMed
  16. Paulsson J, Chattoraj DK. Origin inactivation in bacterial DNA replication control. Mol Microbiol. 2006 Jul; 61(1):9-15.
    View in: PubMed
  17. Bar-Even A, Paulsson J, Maheshri N, Carmi M, O'Shea E, Pilpel Y, Barkai N. Noise in protein expression scales with natural protein abundance. Nat Genet. 2006 Jun; 38(6):636-43.
    View in: PubMed
  18. Springer M, Paulsson J. Biological physics: harmonies from noise. Nature. 2006 Jan 5; 439(7072):27-8.
    View in: PubMed
  19. Golding I, Paulsson J, Zawilski SM, Cox EC. Real-time kinetics of gene activity in individual bacteria. Cell. 2005 Dec 16; 123(6):1025-36.
    View in: PubMed
  20. Paulsson J. Prime movers of noisy gene expression. Nat Genet. 2005 Sep; 37(9):925-6.
    View in: PubMed
  21. Das N, Valjavec-Gratian M, Basuray AN, Fekete RA, Papp PP, Paulsson J, Chattoraj DK. Multiple homeostatic mechanisms in the control of P1 plasmid replication. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2856-61.
    View in: PubMed
  22. Paulsson J. Summing up the noise in gene networks. Nature. 2004 Jan 29; 427(6973):415-8.
    View in: PubMed
  23. Olsson JA, Paulsson J, Nordström K. Effect of the CopB auxiliary replication control system on stability of maintenance of Par(+) plasmid R1. J Bacteriol. 2004 Jan; 186(1):207-11.
    View in: PubMed
  24. Paulsson J. Multileveled selection on plasmid replication. Genetics. 2002 Aug; 161(4):1373-84.
    View in: PubMed
  25. Park K, Han E, Paulsson J, Chattoraj DK. Origin pairing ('handcuffing') as a mode of negative control of P1 plasmid copy number. EMBO J. 2001 Dec 17; 20(24):7323-32.
    View in: PubMed
  26. Paulsson J, Ehrenberg M. Noise in a minimal regulatory network: plasmid copy number control. Q Rev Biophys. 2001 Feb; 34(1):1-59.
    View in: PubMed
  27. Paulsson J, Ehrenberg M. Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks. Phys Rev Lett. 2000 Jun 5; 84(23):5447-50.
    View in: PubMed
  28. Paulsson J, Ehrenberg M. Molecular clocks reduce plasmid loss rates: the R1 case. J Mol Biol. 2000 Mar 17; 297(1):179-92.
    View in: PubMed
  29. Paulsson J, Nordström K, Ehrenberg M. Requirements for rapid plasmid ColE1 copy number adjustments: a mathematical model of inhibition modes and RNA turnover rates. Plasmid. 1998; 39(3):215-34.
    View in: PubMed
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