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Last Name
Institution

Michael R. Freeman, PH.D.

TitleProfessor of Surgery
InstitutionChildren's Hospital Boston
DepartmentSurgery
AddressChildrens Hospital
Enders Bldg., Suite 1161
300 Longwood Ave
Boston MA 02115
Phone617/355-6054
Fax617/738-0238

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Freeman MR, Di Vizio D, Solomon KR. The Rafts of the Medusa: cholesterol targeting in cancer therapy. Oncogene. 2010 Jul 1; 29(26):3745-7.
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  2. Nkolola JP, Peng H, Settembre EC, Freeman M, Grandpre LE, Devoy C, Lynch DM, La Porte A, Simmons NL, Bradley R, Montefiori DC, Seaman MS, Chen B, Barouch DH. Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs. J Virol. 2010 Apr; 84(7):3270-9.
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  3. Yang W, Di Vizio D, Kirchner M, Steen H, Freeman MR. Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Mol Cell Proteomics. 2010 Jan; 9(1):54-70.
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  4. Gallo R, Fefer P, Freeman M, Andrew P, Stewart DJ, Theroux P, Strauss BH. A first-in-man study of percutaneous myocardial cryotreatment in nonrevascularizable patients with refractory angina. Catheter Cardiovasc Interv. 2009 Sep 1; 74(3):387-94.
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  5. D'Egidio G, Nichol G, Williams KA, Guo A, Garrard L, deKemp R, Ruddy TD, DaSilva J, Humen D, Gulenchyn KY, Freeman M, Racine N, Benard F, Hendry P, Beanlands RS. Increasing benefit from revascularization is associated with increasing amounts of myocardial hibernation: a substudy of the PARR-2 trial. JACC Cardiovasc Imaging. 2009 Sep; 2(9):1060-8.
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  6. Di Vizio D, Morello M, Sotgia F, Pestell RG, Freeman MR, Lisanti MP. An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle. 2009 Aug; 8(15):2420-4.
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  7. Freeman MR. Growing evidence that radionuclide imaging identifies management strategies that improve outcome. J Nucl Cardiol. 2009 Nov-Dec; 16(6):844-5.
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  8. Vaezzadeh AR, Steen H, Freeman MR, Lee RS. Proteomics and opportunities for clinical translation in urological disease. J Urol. 2009 Sep; 182(3):835-43.
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  9. Di Vizio D, Kim J, Hager MH, Morello M, Yang W, Lafargue CJ, True LD, Rubin MA, Adam RM, Beroukhim R, Demichelis F, Freeman MR. Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res. 2009 Jul 1; 69(13):5601-9.
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  10. Kim J, Yanagihara Y, Kikugawa T, Ji M, Tanji N, Masayoshi Y, Freeman MR. A signaling network in phenylephrine-induced benign prostatic hyperplasia. Endocrinology. 2009 Aug; 150(8):3576-83.
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  11. Qi M, Liu Y, Freeman MR, Solomon KR. Cholesterol-regulated stress fiber formation. J Cell Biochem. 2009 Apr 15; 106(6):1031-40.
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  12. Stewart DJ, Kutryk MJ, Fitchett D, Freeman M, Camack N, Su Y, Della Siega A, Bilodeau L, Burton JR, Proulx G, Radhakrishnan S. VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial. Mol Ther. 2009 Jun; 17(6):1109-15.
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  13. Mukhopadhyay NK, Kim J, Cinar B, Ramachandran A, Hager MH, Di Vizio D, Adam RM, Rubin MA, Raychaudhuri P, De Benedetti A, Freeman MR. Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res. 2009 Mar 15; 69(6):2210-8.
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  14. Solomon KR, Pelton K, Boucher K, Joo J, Tully C, Zurakowski D, Schaffner CP, Kim J, Freeman MR. Ezetimibe is an inhibitor of tumor angiogenesis. Am J Pathol. 2009 Mar; 174(3):1017-26.
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  15. Kim J, Keay SK, Freeman MR. Heparin-binding epidermal growth factor-like growth factor functionally antagonizes interstitial cystitis antiproliferative factor via mitogen-activated protein kinase pathway activation. BJU Int. 2009 Feb; 103(4):541-6.
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  16. Di Vizio D, Solomon KR, Freeman MR. Cholesterol and cholesterol-rich membranes in prostate cancer: an update. Tumori. 2008 Sep-Oct; 94(5):633-9.
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  17. Lee RS, Monigatti F, Briscoe AC, Waldon Z, Freeman MR, Steen H. Optimizing sample handling for urinary proteomics. J Proteome Res. 2008 Sep; 7(9):4022-30.
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  18. Di Vizio D, Demichelis F, Simonetti S, Pettinato G, Terracciano L, Tornillo L, Freeman MR, Insabato L. Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours. BMC Cancer. 2008; 8:134.
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  19. Di Vizio D, Adam RM, Kim J, Kim R, Sotgia F, Williams T, Demichelis F, Solomon KR, Loda M, Rubin MA, Lisanti MP, Freeman MR. Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. Cell Cycle. 2008 Jul 15; 7(14):2257-67.
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  20. Saban MR, Backer JM, Backer MV, Maier J, Fowler B, Davis CA, Simpson C, Wu XR, Birder L, Freeman MR, Soker S, Hurst RE, Saban R. VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F60-72.
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  21. Solomon KR, Freeman MR. Do the cholesterol-lowering properties of statins affect cancer risk? Trends Endocrinol Metab. 2008 May-Jun; 19(4):113-21.
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  22. Lee RS, Monigatti F, Lutchman M, Patterson T, Budnik B, Steen JA, Freeman MR, Steen H. Temporal variations of the postnatal rat urinary proteome as a reflection of systemic maturation. Proteomics. 2008 Mar; 8(5):1097-112.
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  23. Yang W, Steen H, Freeman MR. Proteomic approaches to the analysis of multiprotein signaling complexes. Proteomics. 2008 Feb; 8(4):832-51.
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  24. Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007 Oct 31; 26(21):4523-34.
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  25. Beanlands RS, Nichol G, Huszti E, Humen D, Racine N, Freeman M, Gulenchyn KY, Garrard L, deKemp R, Guo A, Ruddy TD, Benard F, Lamy A, Iwanochko RM. F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2). J Am Coll Cardiol. 2007 Nov 13; 50(20):2002-12.
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  26. Dimitrakov J, Kroenke K, Steers WD, Berde C, Zurakowski D, Freeman MR, Jackson JL. Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med. 2007 Oct 8; 167(18):1922-9.
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  27. Kim J, Jahng WJ, Di Vizio D, Lee JS, Jhaveri R, Rubin MA, Shisheva A, Freeman MR. The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus. Cancer Res. 2007 Oct 1; 67(19):9229-37.
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  28. Cinar B, Mukhopadhyay NK, Meng G, Freeman MR. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem. 2007 Oct 5; 282(40):29584-93.
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  29. Kim J, Keay SK, Dimitrakov JD, Freeman MR. p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. FEBS Lett. 2007 Aug 7; 581(20):3795-9.
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  30. Adam RM, Mukhopadhyay NK, Kim J, Di Vizio D, Cinar B, Boucher K, Solomon KR, Freeman MR. Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res. 2007 Jul 1; 67(13):6238-46.
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  31. Mukhopadhyay NK, Cinar B, Mukhopadhyay L, Lutchman M, Ferdinand AS, Kim J, Chung LW, Adam RM, Ray SK, Leiter AB, Richie JP, Liu BC, Freeman MR. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol. 2007 Sep; 21(9):2056-70.
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  32. Di Vizio D, Sotgia F, Williams TM, Hassan GS, Capozza F, Frank PG, Pestell RG, Loda M, Freeman MR, Lisanti MP. Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression. Cancer Biol Ther. 2007 Aug; 6(8):1263-8.
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  33. Freeman MR. Beta2 microglobulin: a surprising therapeutic target for prostate cancer and renal cell carcinoma. J Urol. 2007 Jul; 178(1):10-1.
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  34. Park YS, Kim J, Misonou Y, Takamiya R, Takahashi M, Freeman MR, Taniguchi N. Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1319-25.
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  35. Bianco SD, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, Kos CH, Zhuang L, Freeman MR, Gouveia CH, Wu J, Luo H, Mauro T, Brown EM, Hediger MA. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res. 2007 Feb; 22(2):274-85.
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  36. Bax JJ, Inzucchi SE, Bonow RO, Schuijf JD, Freeman MR, Barrett EJ. Cardiac imaging for risk stratification in diabetes. Diabetes Care. 2007 May; 30(5):1295-304.
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  37. Freeman MR, Cinar B, Kim J, Mukhopadhyay NK, Di Vizio D, Adam RM, Solomon KR. Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids. 2007 Feb; 72(2):210-7.
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  38. Fang PK, Solomon KR, Zhuang L, Qi M, McKee M, Freeman MR, Yelick PC. Caveolin-1alpha and -1beta perform nonredundant roles in early vertebrate development. Am J Pathol. 2006 Dec; 169(6):2209-22.
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  39. Goodman JM, Freeman MR, Goodman LS. Left ventricular function during arm exercise: influence of leg cycling and lower body positive pressure. J Appl Physiol. 2007 Mar; 102(3):904-12.
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  40. Estrada CR, Adam RM, Eaton SH, Bägli DJ, Freeman MR. Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder. Lab Invest. 2006 Dec; 86(12):1293-302.
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  41. Duque JL, Loughlin KR, Adam RM, Kantoff P, Mazzucchi E, Freeman MR. Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen. Clinics (Sao Paulo). 2006 Oct; 61(5):401-8.
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  42. Kim KW, Mutter RW, Cao C, Albert JM, Freeman M, Hallahan DE, Lu B. Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling. J Biol Chem. 2006 Dec 1; 281(48):36883-90.
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  43. Farokhzad OC, Dimitrakov JD, Karp JM, Khademhosseini A, Freeman MR, Langer R. Drug delivery systems in urology--getting "smarter". Urology. 2006 Sep; 68(3):463-9.
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  44. Mukhopadhyay NK, Ferdinand AS, Mukhopadhyay L, Cinar B, Lutchman M, Richie JP, Freeman MR, Liu BC. Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor. Exp Cell Res. 2006 Nov 15; 312(19):3782-95.
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  45. Hager MH, Solomon KR, Freeman MR. The role of cholesterol in prostate cancer. Curr Opin Clin Nutr Metab Care. 2006 Jul; 9(4):379-85.
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  46. Freeman MR, Solomon KR, Moyad M. Statins and the risk of cancer. JAMA. 2006 Jun 21; 295(23):2720-1; author reply 2721-2.
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  47. Dimitrakov JD, Kaplan SA, Kroenke K, Jackson JL, Freeman MR. Management of chronic prostatitis/chronic pelvic pain syndrome: an evidence-based approach. Urology. 2006 May; 67(5):881-8.
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  48. Estrada CR, Salanga M, Bielenberg DR, Harrell WB, Zurakowski D, Zhu X, Palmer MR, Freeman MR, Adam RM. Behavioral profiling of human transitional cell carcinoma ex vivo. Cancer Res. 2006 Mar 15; 66(6):3078-86.
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  49. Freeman M. Myocardial perfusion imaging in diabetes mellitus. Can J Cardiol. 2006 Feb; 22 Suppl A:22A-25A.
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  50. MacLellan DL, Steen H, Adam RM, Garlick M, Zurakowski D, Gygi SP, Freeman MR, Solomon KR. A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells. Proteomics. 2005 Dec; 5(18):4733-42.
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  51. Cao C, Shinohara ET, Li H, Niermann KJ, Kim KW, Sekhar KR, Gleave M, Freeman M, Lu B. Clusterin as a therapeutic target for radiation sensitization in a lung cancer model. Int J Radiat Oncol Biol Phys. 2005 Nov 15; 63(4):1228-36.
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  52. Kim J, Adam RM, Freeman MR. Trafficking of nuclear heparin-binding epidermal growth factor-like growth factor into an epidermal growth factor receptor-dependent autocrine loop in response to oxidative stress. Cancer Res. 2005 Sep 15; 65(18):8242-9.
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  53. Marcus K, Johnson M, Adam RM, O'Reilly MS, Donovan M, Atala A, Freeman MR, Soker S. Tumor cell-associated neuropilin-1 and vascular endothelial growth factor expression as determinants of tumor growth in neuroblastoma. Neuropathology. 2005 Sep; 25(3):178-87.
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  54. Freeman MR, Cinar B, Lu ML. Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab. 2005 Aug; 16(6):273-9.
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  55. Koh CJ, Freeman MR, Retik AB. Increasing the ranks of physician-scientists in urology through the promotion of fellowship training: the example of pediatric urology. J Urol. 2005 Jun; 173(6):2110-1.
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  56. Cinar B, De Benedetti A, Freeman MR. Post-transcriptional regulation of the androgen receptor by Mammalian target of rapamycin. Cancer Res. 2005 Apr 1; 65(7):2547-53.
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  57. Zhuang L, Kim J, Adam RM, Solomon KR, Freeman MR. Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest. 2005 Apr; 115(4):959-68.
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  58. Kim J, Lin J, Adam RM, Lamb C, Shively SB, Freeman MR. An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding. J Cell Biochem. 2005 Jan 1; 94(1):39-49.
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  59. Orsola A, Estrada CR, Nguyen HT, Retik AB, Freeman MR, Peters CA, Adam RM. Growth and stretch response of human exstrophy bladder smooth muscle cells: molecular evidence of normal intrinsic function. BJU Int. 2005 Jan; 95(1):144-8.
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  60. Stehr M, Estrada CR, Khoury J, Danciu TE, Sullivan MP, Peters CA, Solomon KR, Freeman MR, Adam RM. Caveolae are negative regulators of transforming growth factor-beta1 signaling in ureteral smooth muscle cells. J Urol. 2004 Dec; 172(6 Pt 1):2451-5.
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  61. Freeman MR. HER2/HER3 heterodimers in prostate cancer: Whither HER1/EGFR? Cancer Cell. 2004 Nov; 6(5):427-8.
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  62. Adam RM, Eaton SH, Estrada C, Nimgaonkar A, Shih SC, Smith LE, Kohane IS, Bägli D, Freeman MR. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics. 2004 Dec 15; 20(1):36-44.
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  63. Danciu TE, Gagari E, Adam RM, Damoulis PD, Freeman MR. Mechanical strain delivers anti-apoptotic and proliferative signals to gingival fibroblasts. J Dent Res. 2004 Aug; 83(8):596-601.
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  64. Lu B, Mu Y, Cao C, Zeng F, Schneider S, Tan J, Price J, Chen J, Freeman M, Hallahan DE. Survivin as a therapeutic target for radiation sensitization in lung cancer. Cancer Res. 2004 Apr 15; 64(8):2840-5.
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  65. Cinar B, Yeung F, Konaka H, Mayo MW, Freeman MR, Zhau HE, Chung LW. Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells. Biochem J. 2004 Apr 15; 379(Pt 2):421-31.
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  66. Freeman MR, Solomon KR. Cholesterol and prostate cancer. J Cell Biochem. 2004 Jan 1; 91(1):54-69.
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  67. Kim J, Adam RM, Solomon KR, Freeman MR. Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Endocrinology. 2004 Feb; 145(2):613-9.
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  68. Segev A, Strauss BH, Coates G, Freeman MR, Gallo R. Endocardial cryotherapy as a novel strategy of improving myocardial perfusion in a patient with severe coronary artery disease. Catheter Cardiovasc Interv. 2003 Oct; 60(2):229-32.
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  69. Adam RM, Roth JA, Cheng HL, Rice DC, Khoury J, Bauer SB, Peters CA, Freeman MR. Signaling through PI3K/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cells. J Urol. 2003 Jun; 169(6):2388-93.
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  70. Kim J, Freeman MR. JNK/SAPK mediates doxorubicin-induced differentiation and apoptosis in MCF-7 breast cancer cells. Breast Cancer Res Treat. 2003 Jun; 79(3):321-8.
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  71. Pinter A, Dorian P, Paquette M, Ng A, Burns M, Spanu I, Freeman M, Korley V, Newman D. Left ventricular performance during acute rate control in atrial fibrillation: the importance of heart rate and agent used. J Cardiovasc Pharmacol Ther. 2003 Mar; 8(1):17-24.
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  72. Stehr M, Adam RM, Khoury J, Zhuang L, Solomon KR, Peters CA, Freeman MR. Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling. J Urol. 2003 Mar; 169(3):1165-70.
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  73. Danciu TE, Adam RM, Naruse K, Freeman MR, Hauschka PV. Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett. 2003 Feb 11; 536(1-3):193-7.
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  74. Adam RM, Danciu T, McLellan DL, Borer JG, Lin J, Zurakowski D, Weinstein MH, Rajjayabun PH, Mellon JK, Freeman MR. A nuclear form of the heparin-binding epidermal growth factor-like growth factor precursor is a feature of aggressive transitional cell carcinoma. Cancer Res. 2003 Jan 15; 63(2):484-90.
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  75. Lin J, Freeman MR. Transactivation of ErbB1 and ErbB2 receptors by angiotensin II in normal human prostate stromal cells. Prostate. 2003 Jan 1; 54(1):1-7.
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  76. Adam RM, Kim J, Lin J, Orsola A, Zhuang L, Rice DC, Freeman MR. Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Endocrinology. 2002 Dec; 143(12):4599-608.
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  77. Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest. 2002 Dec; 82(12):1755-64.
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  78. Beanlands RS, Ruddy TD, deKemp RA, Iwanochko RM, Coates G, Freeman M, Nahmias C, Hendry P, Burns RJ, Lamy A, Mickleborough L, Kostuk W, Fallen E, Nichol G. Positron emission tomography and recovery following revascularization (PARR-1): the importance of scar and the development of a prediction rule for the degree of recovery of left ventricular function. J Am Coll Cardiol. 2002 Nov 20; 40(10):1735-43.
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  79. Lee DS, Barnard M, Freeman MR, Hutchison SJ, Graham AF, Chiu B. Cardiac encasement by metastatic myxoid liposarcoma. Cardiovasc Pathol. 2002 Nov-Dec; 11(6):322-5.
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  80. Jeejeebhoy F, Keith M, Freeman M, Barr A, McCall M, Kurian R, Mazer D, Errett L. Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. Am Heart J. 2002 Jun; 143(6):1092-100.
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  81. Orsola A, Adam RM, Peters CA, Freeman MR. The decision to undergo DNA or protein synthesis is determined by the degree of mechanical deformation in human bladder muscle cells. Urology. 2002 May; 59(5):779-83.
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  82. Zhuang L, Lin J, Lu ML, Solomon KR, Freeman MR. Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res. 2002 Apr 15; 62(8):2227-31.
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  83. Emmett L, Iwanochko RM, Freeman MR, Barolet A, Lee DS, Husain M. Reversible regional wall motion abnormalities on exercise technetium-99m-gated cardiac single photon emission computed tomography predict high-grade angiographic stenoses. J Am Coll Cardiol. 2002 Mar 20; 39(6):991-8.
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  84. Kim J, Adam RM, Freeman MR. Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation. Cancer Res. 2002 Mar 1; 62(5):1549-54.
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  85. Freeman MR, Doe CQ. Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS. Development. 2001 Oct; 128(20):4103-12.
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  86. Soker S, Kaefer M, Johnson M, Klagsbrun M, Atala A, Freeman MR. Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype. Am J Pathol. 2001 Aug; 159(2):651-9.
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  87. Ayan S, Roth JA, Freeman MR, Bride SH, Peters CA. Partial ureteral obstruction dysregulates the renal renin-angiotensin system in the fetal sheep kidney. Urology. 2001 Aug; 58(2):301-6.
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  88. Adam RM, Orsola A, Freeman MR. A novel method for implantation of LNCaP prostate tumor cells under the renal capsule. In Vitro Cell Dev Biol Anim. 2001 Jun; 37(6):360-2.
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  89. Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR. BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation. J Biol Chem. 2001 Aug 10; 276(32):30127-32.
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  90. Peng JB, Zhuang L, Berger UV, Adam RM, Williams BJ, Brown EM, Hediger MA, Freeman MR. CaT1 expression correlates with tumor grade in prostate cancer. Biochem Biophys Res Commun. 2001 Apr 6; 282(3):729-34.
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  91. Verma A, Newman D, Geist M, Greenhut S, Laslop J, DeBellis L, Freeman MR, Dorian P. Effects of rhythm regularization and rate control in improving left ventricular function in atrial fibrillation patients undergoing atrioventricular nodal ablation. Can J Cardiol. 2001 Apr; 17(4):437-45.
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  92. Chiamvimonvat V, Goodman SG, Langer A, Barr A, Freeman MR. Prognostic value of dipyridamole SPECT imaging in low-risk patients after myocardial infarction. J Nucl Cardiol. 2001 Mar-Apr; 8(2):136-43.
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  93. Duque JL, Adam RM, Mullen JS, Lin J, Richie JP, Freeman MR. Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell growth in vitro. J Urol. 2001 Jan; 165(1):284-8.
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  94. Nguyen HT, Adam RM, Bride SH, Park JM, Peters CA, Freeman MR. Cyclic stretch activates p38 SAPK2-, ErbB2-, and AT1-dependent signaling in bladder smooth muscle cells. Am J Physiol Cell Physiol. 2000 Oct; 279(4):C1155-67.
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  95. Nguyen HT, Bride SH, Badawy AB, Adam RM, Lin J, Orsola A, Guthrie PD, Freeman MR, Peters CA. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. Am J Pathol. 2000 Mar; 156(3):889-98.
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  96. Kaefer M, Vemulapalli S, Freeman MR. A nontoxic diphtheria toxin analogue inhibits neonatal bladder smooth muscle cell proliferation. J Urol. 2000 Feb; 163(2):580-4.
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  97. Adam RM, Borer JG, Williams J, Eastham JA, Loughlin KR, Freeman MR. Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate. Endocrinology. 1999 Dec; 140(12):5866-75.
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  98. Haberstroh KM, Kaefer M, Retik AB, Freeman MR, Bizios R. The effects of sustained hydrostatic pressure on select bladder smooth muscle cell functions. J Urol. 1999 Dec; 162(6):2114-8.
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  99. Borer JG, Park JM, Atala A, Nguyen HT, Adam RM, Retik AB, Freeman MR. Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction. Lab Invest. 1999 Nov; 79(11):1335-45.
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  100. Park JM, Bauer SB, Freeman MR, Peters CA. Oxybutynin chloride inhibits proliferation and suppresses gene expression in bladder smooth muscle cells. J Urol. 1999 Sep; 162(3 Pt 2):1110-4.
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  101. Duque JL, Loughlin KR, Adam RM, Kantoff PW, Zurakowski D, Freeman MR. Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. Urology. 1999 Sep; 54(3):523-7.
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  102. Park JM, Adam RM, Peters CA, Guthrie PD, Sun Z, Klagsbrun M, Freeman MR. AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells. Am J Physiol. 1999 Aug; 277(2 Pt 1):C294-301.
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  103. Nguyen HT, Park JM, Peters CA, Adam RM, Orsola A, Atala A, Freeman MR. Cell-specific activation of the HB-EGF and ErbB1 genes by stretch in primary human bladder cells. In Vitro Cell Dev Biol Anim. 1999 Jul-Aug; 35(7):371-5.
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  104. Lin J, Adam RM, Santiestevan E, Freeman MR. The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res. 1999 Jun 15; 59(12):2891-7.
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  105. Clyne PJ, Warr CG, Freeman MR, Lessing D, Kim J, Carlson JR. A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron. 1999 Feb; 22(2):327-38.
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  106. Park JM, Yang T, Arend LJ, Schnermann JB, Peters CA, Freeman MR, Briggs JP. Obstruction stimulates COX-2 expression in bladder smooth muscle cells via increased mechanical stretch. Am J Physiol. 1999 Jan; 276(1 Pt 2):F129-36.
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  107. Park JM, Borer JG, Freeman MR, Peters CA. Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells. Am J Physiol. 1998 Nov; 275(5 Pt 1):C1247-54.
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  108. Dethlefsen SM, Raab G, Moses MA, Adam RM, Klagsbrun M, Freeman MR. Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C. J Cell Biochem. 1998 May 1; 69(2):143-53.
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  109. Moses MA, Wiederschain D, Loughlin KR, Zurakowski D, Lamb CC, Freeman MR. Increased incidence of matrix metalloproteinases in urine of cancer patients. Cancer Res. 1998 Apr 1; 58(7):1395-9.
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  110. Freeman MR, Paul S, Kaefer M, Ishikawa M, Adam RM, Renshaw AA, Elenius K, Klagsbrun M. Heparin-binding EGF-like growth factor in the human prostate: synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen. J Cell Biochem. 1998 Mar 1; 68(3):328-38.
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  111. Freeman MR, Konstantinou C, Barr A, Greyson ND. Clinical comparison of 180-degree and 360-degree data collection of technetium 99m sestamibi SPECT for detection of coronary artery disease. J Nucl Cardiol. 1998 Jan-Feb; 5(1):14-8.
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  112. Freeman MR, Newman D, Dorian P, Barr A, Langer A. Relation of direct assessment of cardiac autonomic function with metaiodobenzylguanidine imaging to heart rate variability in diabetes mellitus. Am J Cardiol. 1997 Jul 15; 80(2):247-50.
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  113. Peters CA, Freeman MR, Fernandez CA, Shepard J, Wiederschain DG, Moses MA. Dysregulated proteolytic balance as the basis of excess extracellular matrix in fibrotic disease. Am J Physiol. 1997 Jun; 272(6 Pt 2):R1960-5.
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  114. Freeman MR, Yoo JJ, Raab G, Soker S, Adam RM, Schneck FX, Renshaw AA, Klagsbrun M, Atala A. Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder. J Clin Invest. 1997 Mar 1; 99(5):1028-36.
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  115. Poppas DP, Stewart RB, Massicotte JM, Wolga AE, Kung RT, Retik AB, Freeman MR. Temperature-controlled laser photocoagulation of soft tissue: in vivo evaluation using a tissue welding model. Lasers Surg Med. 1996; 18(4):335-44.
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  116. Poppas DP, Massicotte JM, Stewart RB, Roberts AB, Atala A, Retik AB, Freeman MR. Human albumin solder supplemented with TGF-beta 1 accelerates healing following laser welded wound closure. Lasers Surg Med. 1996; 19(3):360-8.
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  117. Freeman MR, Schneck FX, Gagnon ML, Corless C, Soker S, Niknejad K, Peoples GE, Klagsbrun M. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. Cancer Res. 1995 Sep 15; 55(18):4140-5.
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  118. Peoples GE, Blotnick S, Takahashi K, Freeman MR, Klagsbrun M, Eberlein TJ. T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role. Proc Natl Acad Sci U S A. 1995 Jul 3; 92(14):6547-51.
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  119. Carr MC, Schlussel RN, Peters CA, Uchida T, Mandell J, Freeman MR. Expression of cell growth regulated genes in the fetal kidney: relevance to in utero obstruction. J Urol. 1995 Jul; 154(1):242-6.
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  120. Legault SE, Langer A, Armstrong PW, Freeman MR. Usefulness of ischemic response to mental stress in predicting silent myocardial ischemia during ambulatory monitoring. Am J Cardiol. 1995 May 15; 75(15):1007-11.
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  121. Langer A, Freeman MR, Josse RG, Armstrong PW. Metaiodobenzylguanidine imaging in diabetes mellitus: assessment of cardiac sympathetic denervation and its relation to autonomic dysfunction and silent myocardial ischemia. J Am Coll Cardiol. 1995 Mar 1; 25(3):610-8.
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  122. Legault SE, Freeman MR, Langer A, Armstrong PW. Pathophysiology and time course of silent myocardial ischaemia during mental stress: clinical, anatomical, and physiological correlates. Br Heart J. 1995 Mar; 73(3):242-9.
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  123. Langer A, Singh N, Freeman MR, Tibshirani R, Armstrong PW. Detection of silent ischemia adds to the prognostic value of coronary anatomy and left ventricular function in predicting outcome in unstable angina patients. Can J Cardiol. 1995 Feb; 11(2):117-22.
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  124. Miller DD, Kiess MC, Freeman MR, Taillefer R. Northern exposure: nuclear cardiology in the Canadian health care system. J Nucl Cardiol. 1995 Jan-Feb; 2(1):53-61.
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  125. Goodman LS, Goodman JM, Yang L, Sloninko J, Hsia T, Freeman MR. Measurement of left ventricular function during arm ergometry using the VEST nuclear probe. Can J Appl Physiol. 1994 Dec; 19(4):462-71.
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  126. Cilento BG, Freeman MR, Schneck FX, Retik AB, Atala A. Phenotypic and cytogenetic characterization of human bladder urothelia expanded in vitro. J Urol. 1994 Aug; 152(2 Pt 2):665-70.
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  127. Goodman LS, Freeman MR, de Yang L, Hsia TW, Chan J. Increased G-suit coverage improves cardiac preloading conditions during positive pressure breathing. Aviat Space Environ Med. 1994 Jul; 65(7):632-40.
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  128. Simmons WW, Freeman MR, Grima EA, Hsia TW, Armstrong PW. Abnormalities of cardiac sympathetic function in pacing-induced heart failure as assessed by [123I]metaiodobenzylguanidine scintigraphy. Circulation. 1994 Jun; 89(6):2843-51.
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  129. Goodman SG, Freeman MR, Armstrong PW, Langer A. Does ambulatory monitoring contribute to exercise testing and myocardial perfusion scintigraphy in the prediction of the extent of coronary artery disease in stable angina? Am J Cardiol. 1994 Apr 15; 73(11):747-52.
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  130. Blotnick S, Peoples GE, Freeman MR, Eberlein TJ, Klagsbrun M. T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):2890-94.
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  131. Edelstein RA, Carr MC, Caesar R, Young M, Atala A, Freeman MR. Detection of human androgen receptor mRNA expression abnormalities by competitive PCR. DNA Cell Biol. 1994 Mar; 13(3):265-73.
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  132. Freeman MR, Bagli DJ, Lamb CC, Guthrie PD, Uchida T, Slavin RE, Chung LW. Culture of a prostatic cell line in basement membrane gels results in an enhancement of malignant properties and constitutive alterations in gene expression. J Cell Physiol. 1994 Feb; 158(2):325-36.
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  133. Singh N, Langer A, Freeman MR, Goldstein MB. Myocardial alterations during hemodialysis: insights from new noninvasive technology. Am J Nephrol. 1994; 14(3):173-81.
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  134. Atala A, Freeman MR, Vacanti JP, Shepard J, Retik AB. Implantation in vivo and retrieval of artificial structures consisting of rabbit and human urothelium and human bladder muscle. J Urol. 1993 Aug; 150(2 Pt 2):608-12.
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  135. Atala A, Freeman MR, Mandell J, Beier DR. Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys. Kidney Int. 1993 May; 43(5):1081-5.
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  136. Hendler AL, Greyson ND, Robinson MG, Freeman MR. Patients with symptomatic ischemia have larger thallium perfusion abnormalities and more adverse prognosis than patients with silent ischemia. Can J Cardiol. 1992 Oct; 8(8):814-8.
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  137. Langer A, Burns RJ, Freeman MR, Liu P, Morgan CD, Wilson R, Armstrong PW. Reverse redistribution on exercise thallium scintigraphy: relationship to coronary patency and ventricular function after myocardial infarction. Can J Cardiol. 1992 Sep; 8(7):709-15.
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  138. Atala A, Vacanti JP, Peters CA, Mandell J, Retik AB, Freeman MR. Formation of urothelial structures in vivo from dissociated cells attached to biodegradable polymer scaffolds in vitro. J Urol. 1992 Aug; 148(2 Pt 2):658-62.
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  139. Hegele RA, Freeman MR, Langer A, Connelly PW, Armstrong PW. Acute reduction of lipoprotein(a) by tissue-type plasminogen activator. Circulation. 1992 Jun; 85(6):2034-8.
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  140. Freeman MR, Langer A, Wilson RF, Morgan CD, Armstrong PW. Thrombolysis in unstable angina. Randomized double-blind trial of t-PA and placebo. Circulation. 1992 Jan; 85(1):150-7.
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  141. Langer A, Freeman MR, Josse RG, Steiner G, Armstrong PW. Detection of silent myocardial ischemia in diabetes mellitus. Am J Cardiol. 1991 May 15; 67(13):1073-8.
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  142. Freeman MR, Song Y, Carson DD, Guthrie PD, Chung LW. Extracellular matrix and androgen receptor expression associated with spontaneous transformation of rat prostate fibroblasts. Cancer Res. 1991 Apr 1; 51(7):1910-6.
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  143. Gotlieb AI, Freeman MR, Salerno TA, Lichtenstein SV, Armstrong PW. Ultrastructural studies of unstable angina in living man. Mod Pathol. 1991 Jan; 4(1):75-80.
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  144. Langer A, Freeman MR, Armstrong PW. Relation of angiographic detected intracoronary thrombus and silent myocardial ischemia in unstable angina pectoris. Am J Cardiol. 1990 Dec 1; 66(19):1381-2.
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  145. Marmur JD, Freeman MR, Langer A, Armstrong PW. Prognosis in medically stabilized unstable angina: early Holter ST-segment monitoring compared with predischarge exercise thallium tomography. Ann Intern Med. 1990 Oct 15; 113(8):575-9.
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  146. Guthrie PD, Freeman MR, Liao ST, Chung LW. Regulation of gene expression in rat prostate by androgen and beta-adrenergic receptor pathways. Mol Endocrinol. 1990 Sep; 4(9):1343-53.
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  147. Camps JL, Chang SM, Hsu TC, Freeman MR, Hong SJ, Zhau HE, von Eschenbach AC, Chung LW. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):75-9.
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  148. Freeman MR, Washecka R, Chung LW. Aberrant expression of epidermal growth factor receptor and HER-2 (erbB-2) messenger RNAs in human renal cancers. Cancer Res. 1989 Nov 15; 49(22):6221-5.
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  149. Morrison M, Fairholm S, Freeman MR. New etiology for intestinal uptake of thallium-201. Clin Nucl Med. 1989 Oct; 14(10):764-6.
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  150. Freeman MR, Williams AE, Chisholm RJ, Armstrong PW. Intracoronary thrombus and complex morphology in unstable angina. Relation to timing of angiography and in-hospital cardiac events. Circulation. 1989 Jul; 80(1):17-23.
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  151. Freeman MR, Beckmann SL, Sueoka N. Regulation of the S100 protein and GFAP genes is mediated by two common mechanisms in RT4 neuro-glial cell lines. Exp Cell Res. 1989 Jun; 182(2):370-83.
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  152. Armstrong PW, Baigrie RS, Daly PA, Haq A, Gent M, Roberts RS, Freeman MR, Burns R, Liu P, Morgan CD. Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction. J Am Coll Cardiol. 1989 Jun; 13(7):1469-76.
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  153. Langer A, Freeman MR, Armstrong PW. ST segment shift in unstable angina: pathophysiology and association with coronary anatomy and hospital outcome. J Am Coll Cardiol. 1989 Jun; 13(7):1495-502.
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  154. Ranganathan N, Sivaciyan V, Pryszlak M, Freeman MR. Changes in jugular venous flow velocity after coronary artery bypass grafting. Am J Cardiol. 1989 Mar 15; 63(11):725-9.
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  155. Freeman MR, Williams AE, Chisholm RJ, Patt NL, Greyson ND, Armstrong PW. Role of resting thallium201 perfusion in predicting coronary anatomy, left ventricular wall motion, and hospital outcome in unstable angina pectoris. Am Heart J. 1989 Feb; 117(2):306-14.
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  156. Freeman MR, Kanwar N, Armstrong PW. Comparison of rest and exercise thallium-201 kinetics in man and implications for quantitation. Am J Physiol Imaging. 1989; 4(1):4-10.
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  157. Freeman MR, Chisholm RJ, Armstrong PW. Usefulness of exercise electrocardiography and thallium scintigraphy in unstable angina pectoris in predicting the extent and severity of coronary artery disease. Am J Cardiol. 1988 Dec 1; 62(17):1164-70.
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  158. Williams AE, Freeman MR, Chisholm RJ, Patt NL, Armstrong PW. Angiographic morphology in unstable angina pectoris. Am J Cardiol. 1988 Nov 15; 62(16):1024-7.
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  159. Freeman MR, Berman DS, Staniloff HM, Waxman AD, Maddahi J, Buchbinder NA, Forrester JS, Swan HJ. Improved assessment of inferior segmental wall motion by the addition of a 70-degree left anterior oblique view in multiple gated equilibrium scintigraphy. Am Heart J. 1981 Feb; 101(2):169-73.
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  160. Levene DL, Freeman MR. Alpha-adrenoceptor-mediated coronary artery spasm. JAMA. 1976 Aug 30; 236(9):1018-22.
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