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John J. Guinan Jr., PH.D.

TitleProfessor of Otology and Laryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtology and Laryngology
AddressMassachusetts Eye & Ear Infrm
Eaton Peabody Lab
243 Charles St
Boston MA 02114
Phone617/573-3745
Fax617/720-4408
Other Positions
TitleProfessor of Health Sciences and Technology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentHealth Sciences and Technology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Milojcic R, Guinan JJ, Rauch SD, Herrmann BS. Vestibular evoked myogenic potentials in patients with superior semicircular canal dehiscence. Otol Neurotol. 2013 Feb; 34(2):360-7.
    View in: PubMed
  2. Lichtenhan JT, Cooper NP, Guinan JJ. A new auditory threshold estimation technique for low frequencies: proof of concept. Ear Hear. 2013 Jan; 34(1):42-51.
    View in: PubMed
  3. Guinan JJ. How are inner hair cells stimulated? Evidence for multiple mechanical drives. Hear Res. 2012 Oct; 292(1-2):35-50.
    View in: PubMed
  4. Guinan JJ, Salt A, Cheatham MA. Progress in cochlear physiology after Békésy. Hear Res. 2012 Nov; 293(1-2):12-20.
    View in: PubMed
  5. Lilaonitkul W, Guinan JJ. Frequency tuning of medial-olivocochlear-efferent acoustic reflexes in humans as functions of probe frequency. J Neurophysiol. 2012 Mar; 107(6):1598-611.
    View in: PubMed
  6. Shera CA, Olson ES, Guinan JJ. On cochlear impedances and the miscomputation of power gain. J Assoc Res Otolaryngol. 2011 Dec; 12(6):671-6.
    View in: PubMed
  7. Guinan JJ. Cochlear efferent innervation and function. Curr Opin Otolaryngol Head Neck Surg. 2010 Oct; 18(5):447-53.
    View in: PubMed
  8. Shera CA, Guinan JJ, Oxenham AJ. Otoacoustic estimation of cochlear tuning: validation in the chinchilla. J Assoc Res Otolaryngol. 2010 Sep; 11(3):343-65.
    View in: PubMed
  9. Francis NA, Guinan JJ. Acoustic stimulation of human medial olivocochlear efferents reduces stimulus-frequency and click-evoked otoacoustic emission delays: Implications for cochlear filter bandwidths. Hear Res. 2010 Aug; 267(1-2):36-45.
    View in: PubMed
  10. Lilaonitkul W, Guinan JJ. Human medial olivocochlear reflex: effects as functions of contralateral, ipsilateral, and bilateral elicitor bandwidths. J Assoc Res Otolaryngol. 2009 Sep; 10(3):459-70.
    View in: PubMed
  11. Lilaonitkul W, Guinan JJ. Reflex control of the human inner ear: a half-octave offset in medial efferent feedback that is consistent with an efferent role in the control of masking. J Neurophysiol. 2009 Mar; 101(3):1394-406.
    View in: PubMed
  12. Guinan JJ, Cooper NP. Medial olivocochlear efferent inhibition of basilar-membrane responses to clicks: evidence for two modes of cochlear mechanical excitation. J Acoust Soc Am. 2008 Aug; 124(2):1080-92.
    View in: PubMed
  13. Backus BC, Guinan JJ. Measurement of the distribution of medial olivocochlear acoustic reflex strengths across normal-hearing individuals via otoacoustic emissions. J Assoc Res Otolaryngol. 2007 Dec; 8(4):484-96.
    View in: PubMed
  14. Shera CA, Tubis A, Talmadge CL, de Boer E, Fahey PF, Guinan JJ. Allen-Fahey and related experiments support the predominance of cochlear slow-wave otoacoustic emissions. J Acoust Soc Am. 2007 Mar; 121(3):1564-75.
    View in: PubMed
  15. Shera CA, Guinan JJ. Cochlear traveling-wave amplification, suppression, and beamforming probed using noninvasive calibration of intracochlear distortion sources. J Acoust Soc Am. 2007 Feb; 121(2):1003-16.
    View in: PubMed
  16. Guinan JJ. Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans. Ear Hear. 2006 Dec; 27(6):589-607.
    View in: PubMed
  17. Cooper NP, Guinan JJ. Efferent-mediated control of basilar membrane motion. J Physiol. 2006 Oct 1; 576(Pt 1):49-54.
    View in: PubMed
  18. Lin MY, Timmer FC, Oriel BS, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Merchant SN, Rauch SD. Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops. Laryngoscope. 2006 Jun; 116(6):987-92.
    View in: PubMed
  19. Backus BC, Guinan JJ. Time-course of the human medial olivocochlear reflex. J Acoust Soc Am. 2006 May; 119(5 Pt 1):2889-904.
    View in: PubMed
  20. Timmer FC, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Rauch SD. Vestibular evoked myogenic potential (VEMP) in patients with Ménière's disease with drop attacks. Laryngoscope. 2006 May; 116(5):776-9.
    View in: PubMed
  21. Lee DJ, de Venecia RK, Guinan JJ, Brown MC. Central auditory pathways mediating the rat middle ear muscle reflexes. Anat Rec A Discov Mol Cell Evol Biol. 2006 Apr; 288(4):358-69.
    View in: PubMed
  22. Guinan JJ, Lin T, Cheng H. Medial-olivocochlear-efferent inhibition of the first peak of auditory-nerve responses: evidence for a new motion within the cochlea. J Acoust Soc Am. 2005 Oct; 118(4):2421-33.
    View in: PubMed
  23. de Venecia RK, Liberman MC, Guinan JJ, Brown MC. Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs. J Comp Neurol. 2005 Jul 11; 487(4):345-60.
    View in: PubMed
  24. Rauch SD, Silveira MB, Zhou G, Kujawa SG, Wall C, Guinan JJ, Herrmann BS. Vestibular evoked myogenic potentials versus vestibular test battery in patients with Meniere's disease. Otol Neurotol. 2004 Nov; 25(6):981-6.
    View in: PubMed
  25. Liberman MC, Zuo J, Guinan JJ. Otoacoustic emissions without somatic motility: can stereocilia mechanics drive the mammalian cochlea? J Acoust Soc Am. 2004 Sep; 116(3):1649-55.
    View in: PubMed
  26. Harms MP, Guinan JJ, Sigalovsky IS, Melcher JR. Short-term sound temporal envelope characteristics determine multisecond time patterns of activity in human auditory cortex as shown by fMRI. J Neurophysiol. 2005 Jan; 93(1):210-22.
    View in: PubMed
  27. Lin T, Guinan JJ. Time-frequency analysis of auditory-nerve-fiber and basilar-membrane click responses reveal glide irregularities and non-characteristic-frequency skirts. J Acoust Soc Am. 2004 Jul; 116(1):405-16.
    View in: PubMed
  28. Rauch SD, Zhou G, Kujawa SG, Guinan JJ, Herrmann BS. Vestibular evoked myogenic potentials show altered tuning in patients with Ménière's disease. Otol Neurotol. 2004 May; 25(3):333-8.
    View in: PubMed
  29. Brown MC, de Venecia RK, Guinan JJ. Responses of medial olivocochlear neurons. Specifying the central pathways of the medial olivocochlear reflex. Exp Brain Res. 2003 Dec; 153(4):491-8.
    View in: PubMed
  30. Guinan JJ, Backus BC, Lilaonitkul W, Aharonson V. Medial olivocochlear efferent reflex in humans: otoacoustic emission (OAE) measurement issues and the advantages of stimulus frequency OAEs. J Assoc Res Otolaryngol. 2003 Dec; 4(4):521-40.
    View in: PubMed
  31. Shera CA, Guinan JJ. Stimulus-frequency-emission group delay: a test of coherent reflection filtering and a window on cochlear tuning. J Acoust Soc Am. 2003 May; 113(5):2762-72.
    View in: PubMed
  32. Cooper NP, Guinan JJ. Separate mechanical processes underlie fast and slow effects of medial olivocochlear efferent activity. J Physiol. 2003 Apr 1; 548(Pt 1):307-12.
    View in: PubMed
  33. Shera CA, Guinan JJ, Oxenham AJ. Revised estimates of human cochlear tuning from otoacoustic and behavioral measurements. Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5):3318-23.
    View in: PubMed
  34. Stankovic KM, Guinan JJ. Medial efferent effects on auditory-nerve responses to tail-frequency tones II: alteration of phase. J Acoust Soc Am. 2000 Aug; 108(2):664-78.
    View in: PubMed
  35. Lin T, Guinan JJ. Auditory-nerve-fiber responses to high-level clicks: interference patterns indicate that excitation is due to the combination of multiple drives. J Acoust Soc Am. 2000 May; 107(5 Pt 1):2615-30.
    View in: PubMed
  36. Melcher JR, Sigalovsky IS, Guinan JJ, Levine RA. Lateralized tinnitus studied with functional magnetic resonance imaging: abnormal inferior colliculus activation. J Neurophysiol. 2000 Feb; 83(2):1058-72.
    View in: PubMed
  37. Stankovic KM, Guinan JJ. Medial efferent effects on auditory-nerve responses to tail-frequency tones. I. Rate reduction. J Acoust Soc Am. 1999 Aug; 106(2):857-69.
    View in: PubMed
  38. Wiener-Vacher SR, Guinan JJ, Kobler JB, Norris BE. Motoneuron axon distribution in the cat stapedius muscle. Hear Res. 1999 Jul; 133(1-2):139-48.
    View in: PubMed
  39. Shera CA, Guinan JJ. Evoked otoacoustic emissions arise by two fundamentally different mechanisms: a taxonomy for mammalian OAEs. J Acoust Soc Am. 1999 Feb; 105(2 Pt 1):782-98.
    View in: PubMed
  40. Liberman MC, Guinan JJ. Feedback control of the auditory periphery: anti-masking effects of middle ear muscles vs. olivocochlear efferents. J Commun Disord. 1998 Nov-Dec; 31(6):471-82; quiz 483; 553.
    View in: PubMed
  41. Pang XD, Guinan JJ. Effects of stapedius-muscle contractions on the masking of auditory-nerve responses. J Acoust Soc Am. 1997 Dec; 102(6):3576-86.
    View in: PubMed
  42. Pang XD, Guinan JJ. Growth rate of simultaneous masking in cat auditory-nerve fibers: relationship to the growth of basilar-membrane motion and the origin of two-tone suppression. J Acoust Soc Am. 1997 Dec; 102(6):3564-75.
    View in: PubMed
  43. McCue MP, Guinan JJ. Sound-evoked activity in primary afferent neurons of a mammalian vestibular system. Am J Otol. 1997 May; 18(3):355-60.
    View in: PubMed
  44. Guinan JJ, Stankovic KM. Medial efferent inhibition produces the largest equivalent attenuations at moderate to high sound levels in cat auditory-nerve fibers. J Acoust Soc Am. 1996 Sep; 100(3):1680-90.
    View in: PubMed
  45. Liberman MC, Puria S, Guinan JJ. The ipsilaterally evoked olivocochlear reflex causes rapid adaptation of the 2f1-f2 distortion product otoacoustic emission. J Acoust Soc Am. 1996 Jun; 99(6):3572-84.
    View in: PubMed
  46. Melcher JR, Knudson IM, Fullerton BC, Guinan JJ, Norris BE, Kiang NY. Generators of the brainstem auditory evoked potential in cat. I. An experimental approach to their identification. Hear Res. 1996 Apr; 93(1-2):1-27.
    View in: PubMed
  47. Melcher JR, Guinan JJ, Knudson IM, Kiang NY. Generators of the brainstem auditory evoked potential in cat. II. Correlating lesion sites with waveform changes. Hear Res. 1996 Apr; 93(1-2):28-51.
    View in: PubMed
  48. Puria S, Guinan JJ, Liberman MC. Olivocochlear reflex assays: effects of contralateral sound on compound action potentials versus ear-canal distortion products. J Acoust Soc Am. 1996 Jan; 99(1):500-7.
    View in: PubMed
  49. McCue MP, Guinan JJ. Spontaneous activity and frequency selectivity of acoustically responsive vestibular afferents in the cat. J Neurophysiol. 1995 Oct; 74(4):1563-72.
    View in: PubMed
  50. McCue MP, Guinan JJ. Acoustically responsive fibers in the vestibular nerve of the cat. J Neurosci. 1994 Oct; 14(10):6058-70.
    View in: PubMed
  51. McCue MP, Guinan JJ. Influence of efferent stimulation on acoustically responsive vestibular afferents in the cat. J Neurosci. 1994 Oct; 14(10):6071-83.
    View in: PubMed
  52. Kobler JB, Guinan JJ, Vacher SR, Norris BE. Acoustic reflex frequency selectivity in single stapedius motoneurons of the cat. J Neurophysiol. 1992 Sep; 68(3):807-17.
    View in: PubMed
  53. Guinan JJ, Li RY. Signal processing in brainstem auditory neurons which receive giant endings (calyces of Held) in the medial nucleus of the trapezoid body of the cat. Hear Res. 1990 Nov; 49(1-3):321-34.
    View in: PubMed
  54. Vacher SR, Guinan JJ, Kobler JB. Intracellularly labeled stapedius-motoneuron cell bodies in the cat are spatially organized according to their physiologic responses. J Comp Neurol. 1989 Nov 15; 289(3):401-15.
    View in: PubMed
  55. Guinan JJ, Joseph MP, Norris BE. Brainstem facial-motor pathways from two distinct groups of stapedius motoneurons in the cat. J Comp Neurol. 1989 Sep 1; 287(1):134-44.
    View in: PubMed
  56. Guinan JJ, Gifford ML. Effects of electrical stimulation of efferent olivocochlear neurons on cat auditory-nerve fibers. III. Tuning curves and thresholds at CF. Hear Res. 1988 Dec; 37(1):29-45.
    View in: PubMed
  57. McCue MP, Guinan JJ. Anatomical and functional segregation in the stapedius motoneuron pool of the cat. J Neurophysiol. 1988 Sep; 60(3):1160-80.
    View in: PubMed
  58. Guinan JJ, Gifford ML. Effects of electrical stimulation of efferent olivocochlear neurons on cat auditory-nerve fibers. I. Rate-level functions. Hear Res. 1988 May; 33(2):97-113.
    View in: PubMed
  59. Guinan JJ, Gifford ML. Effects of electrical stimulation of efferent olivocochlear neurons on cat auditory-nerve fibers. II. Spontaneous rate. Hear Res. 1988 May; 33(2):115-27.
    View in: PubMed
  60. Kobler JB, Vacher SR, Guinan JJ. The recruitment order of stapedius motoneurons in the acoustic reflex varies with sound laterality. Brain Res. 1987 Nov 10; 425(2):372-5.
    View in: PubMed
  61. Guinan JJ, McCue MP. Asymmetries in the acoustic reflexes of the cat stapedius muscle. Hear Res. 1987; 26(1):1-10.
    View in: PubMed
  62. Gifford ML, Guinan JJ. Effects of electrical stimulation of medial olivocochlear neurons on ipsilateral and contralateral cochlear responses. Hear Res. 1987; 29(2-3):179-94.
    View in: PubMed
  63. Guinan JJ. Effect of efferent neural activity on cochlear mechanics. Scand Audiol Suppl. 1986; 25:53-62.
    View in: PubMed
  64. Kiang NY, Liberman MC, Sewell WF, Guinan JJ. Single unit clues to cochlear mechanisms. Hear Res. 1986; 22:171-82.
    View in: PubMed
  65. Joseph MP, Guinan JJ, Fullerton BC, Norris BE, Kiang NY. Number and distribution of stapedius motoneurons in cats. J Comp Neurol. 1985 Feb 1; 232(1):43-54.
    View in: PubMed
  66. Guinan JJ, Warr WB, Norris BE. Topographic organization of the olivocochlear projections from the lateral and medial zones of the superior olivary complex. J Comp Neurol. 1984 Jun 10; 226(1):21-7.
    View in: PubMed
  67. Guinan JJ, Warr WB, Norris BE. Differential olivocochlear projections from lateral versus medial zones of the superior olivary complex. J Comp Neurol. 1983 Dec 10; 221(3):358-70.
    View in: PubMed
  68. Gifford ML, Guinan JJ. Effects of crossed-olivocochlear-bundle stimulation on cat auditory nerve fiber responses to tones. J Acoust Soc Am. 1983 Jul; 74(1):115-23.
    View in: PubMed
  69. Guinan JJ. The decay of end-plate currents in neostigmine-treated frog muscle blocked by acetylcholine or tubocurarine. J Physiol. 1980 Aug; 305:345-55.
    View in: PubMed
  70. Warr WB, Guinan JJ. Efferent innervation of the organ of corti: two separate systems. Brain Res. 1979 Sep 7; 173(1):152-5.
    View in: PubMed
  71. Guinan JJ Jr, Guinan SS, Norris BE. Single auditory units in the superior olivary complex. I: Responses to sounds and classifications based on physiological properties. Intern J Neuroscience. 1972; 4:101-120.
  72. Guinan JJ Jr, Norris BE, Guinan SS. Single auditory units in the superior olivary complex. II: Tonotopic organization and locations of unit categories. Intern J Neuroscience. 1972; 4:147-166.
  73. Guinan JJ, Peake WT. Middle-ear characteristics of anesthetized cats. J Acoust Soc Am. 1967 May; 41(5):1237-61.
    View in: PubMed
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