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Last Name
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Matthew K Waldor, M.D., Ph.D.

TitleEdward H. Kass Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressChanning Laboratory
Mcp-769
181 Longwood Ave
Boston MA 02115
Phone617/525-4646
Fax617/525-4660

 Mentoring 
 current student opportunities
Available: 06/30/12, Expires: 06/30/13

Our lab studies the biology of Vibrio cholerae, the agent of cholera, and E. coli O157, a common cause of diarrheal disease in the USA. We are using a wide range of techniques to understand how these pathogens cause disease. We study both basic questions, such as how bacterial chromosomes replicate and segregate, and more applied issues such as development of new antibiotics and vaccines for diarrheal diseases.

Available: 09/03/12, Expires: 08/30/13

Our lab studies the biology of Vibrio cholerae, the agent of cholera, and E. coli O157, a common cause of diarrheal disease in the USA. We are using a wide range of techniques to understand how these pathogens cause disease. We study both basic questions, such as how bacterial chromosomes replicate and segregate, and more applied issues such as development of new antibiotics and vaccines for diarrheal diseases.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Davis BM, Waldor MK. Horizontal gene transfer: linking sex and cell fate. Curr Biol. 2013 Feb 4; 23(3):R118-9.
    View in: PubMed
  2. Grad YH, Godfrey P, Cerquiera GC, Mariani-Kurkdjian P, Gouali M, Bingen E, Shea TP, Haas BJ, Griggs A, Young S, Zeng Q, Lipsitch M, Waldor MK, Weill FX, Wortman JR, Hanage WP. Comparative Genomics of Recent Shiga Toxin-Producing Escherichia coli O104:H4: Short-Term Evolution of an Emerging Pathogen. MBio. 2013; 4(1).
    View in: PubMed
  3. Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V. Fucose sensing regulates bacterial intestinal colonization. Nature. 2012 Dec 4; 492(7427):113-7.
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  4. Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, Banerjee O, Feng Z, Losic B, Mahajan MC, Jabado OJ, Deikus G, Clark TA, Luong K, Murray IA, Davis BM, Keren-Paz A, Chess A, Roberts RJ, Korlach J, Turner SW, Kumar V, Waldor MK, Schadt EE. Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nat Biotechnol. 2012 Dec 7; 30(12):1232-9.
    View in: PubMed
  5. Yamaichi Y, Bruckner R, Ringgaard S, Möll A, Cameron DE, Briegel A, Jensen GJ, Davis BM, Waldor MK. A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole. Genes Dev. 2012 Oct 15; 26(20):2348-60.
    View in: PubMed
  6. Mekalanos JJ, Robins W, Ussery DW, Davis BM, Schadt E, Waldor MK. Non-O1 Vibrio cholerae unlinked to cholera in Haiti. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):E3206.
    View in: PubMed
  7. Ford CG, Kolappan S, Phan HT, Waldor MK, Winther-Larsen HC, Craig L. Crystal Structures of a CTX{varphi} pIII Domain Unbound and in Complex with a Vibrio cholerae TolA Domain Reveal Novel Interaction Interfaces. J Biol Chem. 2012 Oct 19; 287(43):36258-72.
    View in: PubMed
  8. Hatzios SK, Ringgaard S, Davis BM, Waldor MK. Studies of dynamic protein-protein interactions in bacteria using Renilla luciferase complementation are undermined by nonspecific enzyme inhibition. PLoS One. 2012; 7(8):e43175.
    View in: PubMed
  9. Bashir A, Klammer AA, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, Mollova E, Luong K, Lin S, LaMay B, Joshi A, Rowe L, Frace M, Tarr CL, Turnsek M, Davis BM, Kasarskis A, Mekalanos JJ, Waldor MK, Schadt EE. A hybrid approach for the automated finishing of bacterial genomes. Nat Biotechnol. 2012 Jul; 30(7):701-7.
    View in: PubMed
  10. Zhou X, Ritchie JM, Hiyoshi H, Iida T, Davis BM, Waldor MK, Kodama T. The hydrophilic translocator for Vibrio parahaemolyticus, T3SS2, is also translocated. Infect Immun. 2012 Aug; 80(8):2940-7.
    View in: PubMed
  11. Ritchie JM, Rui H, Zhou X, Iida T, Kodoma T, Ito S, Davis BM, Bronson RT, Waldor MK. Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea. PLoS Pathog. 2012; 8(3):e1002593.
    View in: PubMed
  12. Lloyd SJ, Ritchie JM, Rojas-Lopez M, Blumentritt CA, Popov VL, Greenwich JL, Waldor MK, Torres AG. A double, long polar fimbria mutant of Escherichia coli O157:H7 expresses Curli and exhibits reduced in vivo colonization. Infect Immun. 2012 Mar; 80(3):914-20.
    View in: PubMed
  13. Ritchie JM, Greenwich JL, Davis BM, Bronson RT, Gebhart D, Williams SR, Martin D, Scholl D, Waldor MK. An Escherichia coli O157-specific engineered pyocin prevents and ameliorates infection by E. coli O157:H7 in an animal model of diarrheal disease. Antimicrob Agents Chemother. 2011 Dec; 55(12):5469-74.
    View in: PubMed
  14. Mandlik A, Livny J, Robins WP, Ritchie JM, Mekalanos JJ, Waldor MK. RNA-Seq-based monitoring of infection-linked changes in Vibrio cholerae gene expression. Cell Host Microbe. 2011 Aug 18; 10(2):165-74.
    View in: PubMed
  15. Rasko DA, Webster DR, Sahl JW, Bashir A, Boisen N, Scheutz F, Paxinos EE, Sebra R, Chin CS, Iliopoulos D, Klammer A, Peluso P, Lee L, Kislyuk AO, Bullard J, Kasarskis A, Wang S, Eid J, Rank D, Redman JC, Steyert SR, Frimodt-Møller J, Struve C, Petersen AM, Krogfelt KA, Nataro JP, Schadt EE, Waldor MK. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med. 2011 Aug 25; 365(8):709-17.
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  16. Cava F, de Pedro MA, Lam H, Davis BM, Waldor MK. Distinct pathways for modification of the bacterial cell wall by non-canonical D-amino acids. EMBO J. 2011 Aug 17; 30(16):3442-53.
    View in: PubMed
  17. Yamaichi Y, Gerding MA, Davis BM, Waldor MK. Regulatory cross-talk links Vibrio cholerae chromosome II replication and segregation. PLoS Genet. 2011 Jul; 7(7):e1002189.
    View in: PubMed
  18. Ringgaard S, Schirner K, Davis BM, Waldor MK. A family of ParA-like ATPases promotes cell pole maturation by facilitating polar localization of chemotaxis proteins. Genes Dev. 2011 Jul 15; 25(14):1544-55.
    View in: PubMed
  19. Shin OS, Tam VC, Suzuki M, Ritchie JM, Bronson RT, Waldor MK, Mekalanos JJ. Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae. MBio. 2011; 2(3):e00106-11.
    View in: PubMed
  20. Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL. Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care. PLoS Negl Trop Dis. 2011; 5(5):e1145.
    View in: PubMed
  21. Cava F, Lam H, de Pedro MA, Waldor MK. Emerging knowledge of regulatory roles of D-amino acids in bacteria. Cell Mol Life Sci. 2011 Mar; 68(5):817-31.
    View in: PubMed
  22. Chin CS, Sorenson J, Harris JB, Robins WP, Charles RC, Jean-Charles RR, Bullard J, Webster DR, Kasarskis A, Peluso P, Paxinos EE, Yamaichi Y, Calderwood SB, Mekalanos JJ, Schadt EE, Waldor MK. The origin of the Haitian cholera outbreak strain. N Engl J Med. 2011 Jan 6; 364(1):33-42.
    View in: PubMed
  23. Yuan J, Yamaichi Y, Waldor MK. The three vibrio cholerae chromosome II-encoded ParE toxins degrade chromosome I following loss of chromosome II. J Bacteriol. 2011 Feb; 193(3):611-9.
    View in: PubMed
  24. Waldor MK, Hotez PJ, Clemens JD. A national cholera vaccine stockpile--a new humanitarian and diplomatic resource. N Engl J Med. 2010 Dec 9; 363(24):2279-82.
    View in: PubMed
  25. Waldor MK. Mobilizable genomic islands: going mobile with oriT mimicry. Mol Microbiol. 2010 Nov; 78(3):537-40.
    View in: PubMed
  26. Yuan J, Sterckx Y, Mitchenall LA, Maxwell A, Loris R, Waldor MK. Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. J Biol Chem. 2010 Dec 17; 285(51):40397-408.
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  27. Le Roux F, Davis BM, Waldor MK. Conserved small RNAs govern replication and incompatibility of a diverse new plasmid family from marine bacteria. Nucleic Acids Res. 2011 Feb; 39(3):1004-13.
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  28. Le Roux F, Labreuche Y, Davis BM, Iqbal N, Mangenot S, Goarant C, Mazel D, Waldor MK. Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids. Environ Microbiol. 2011 Feb; 13(2):296-306.
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  29. Wozniak RA, Waldor MK. Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat Rev Microbiol. 2010 Aug; 8(8):552-63.
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  30. Ritchie JM, Rui H, Bronson RT, Waldor MK. Back to the future: studying cholera pathogenesis using infant rabbits. MBio. 2010 Apr; 1(1).
    View in: PubMed
  31. Hui MP, Galkin VE, Yu X, Stasiak AZ, Stasiak A, Waldor MK, Egelman EH. ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA. Proc Natl Acad Sci U S A. 2010 Mar 9; 107(10):4590-5.
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  32. Rui H, Ritchie JM, Bronson RT, Mekalanos JJ, Zhang Y, Waldor MK. Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4359-64.
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  33. Wozniak RA, Fouts DE, Spagnoletti M, Colombo MM, Ceccarelli D, Garriss G, Déry C, Burrus V, Waldor MK. Comparative ICE genomics: insights into the evolution of the SXT/R391 family of ICEs. PLoS Genet. 2009 Dec; 5(12):e1000786.
    View in: PubMed
  34. Garriss G, Waldor MK, Burrus V. Mobile antibiotic resistance encoding elements promote their own diversity. PLoS Genet. 2009 Dec; 5(12):e1000775.
    View in: PubMed
  35. Livny J, Waldor MK. Mining regulatory 5'UTRs from cDNA deep sequencing datasets. Nucleic Acids Res. 2010 Mar; 38(5):1504-14.
    View in: PubMed
  36. Yamaichi Y, Duigou S, Shakhnovich EA, Waldor MK. Targeting the replication initiator of the second Vibrio chromosome: towards generation of vibrionaceae-specific antimicrobial agents. PLoS Pathog. 2009 Nov; 5(11):e1000663.
    View in: PubMed
  37. Lam H, Oh DC, Cava F, Takacs CN, Clardy J, de Pedro MA, Waldor MK. D-amino acids govern stationary phase cell wall remodeling in bacteria. Science. 2009 Sep 18; 325(5947):1552-5.
    View in: PubMed
  38. Shakhnovich EA, Davis BM, Waldor MK. Hfq negatively regulates type III secretion in EHEC and several other pathogens. Mol Microbiol. 2009 Oct; 74(2):347-63.
    View in: PubMed
  39. Kimsey HH, Waldor MK. Vibrio cholerae LexA coordinates CTX prophage gene expression. J Bacteriol. 2009 Nov; 191(22):6788-95.
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  40. Davis BM, Waldor MK. High-throughput sequencing reveals suppressors of Vibrio cholerae rpoE mutations: one fewer porin is enough. Nucleic Acids Res. 2009 Sep; 37(17):5757-67.
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  41. Kulasekara BR, Jacobs M, Zhou Y, Wu Z, Sims E, Saenphimmachak C, Rohmer L, Ritchie JM, Radey M, McKevitt M, Freeman TL, Hayden H, Haugen E, Gillett W, Fong C, Chang J, Beskhlebnaya V, Waldor MK, Samadpour M, Whittam TS, Kaul R, Brittnacher M, Miller SI. Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence. Infect Immun. 2009 Sep; 77(9):3713-21.
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  42. Slamti L, Waldor MK. Genetic analysis of activation of the Vibrio cholerae Cpx pathway. J Bacteriol. 2009 Aug; 191(16):5044-56.
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  43. Grall N, Livny J, Waldor M, Barel M, Charbit A, Meibom KL. Pivotal role of the Francisella tularensis heat-shock sigma factor RpoH. Microbiology. 2009 Aug; 155(Pt 8):2560-72.
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  44. Wozniak RA, Waldor MK. A toxin-antitoxin system promotes the maintenance of an integrative conjugative element. PLoS Genet. 2009 Mar; 5(3):e1000439.
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  45. Liu JM, Livny J, Lawrence MS, Kimball MD, Waldor MK, Camilli A. Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing. Nucleic Acids Res. 2009 Apr; 37(6):e46.
    View in: PubMed
  46. Ritchie JM, Waldor MK. Vibrio cholerae interactions with the gastrointestinal tract: lessons from animal studies. Curr Top Microbiol Immunol. 2009; 337:37-59.
    View in: PubMed
  47. Waldor MK, Steinman L, Sriram S, Herzenberg L, Herzenberg L. Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells. 2009.
  48. Waldor MK, Mekalanos JJ. Vibrio cholerae having increased sensitivity to antibiotics. 2009.
  49. Waldor MK, Egan E. Vibrionaceae replication factors and methods of use thereof. 2009.
  50. Vazquez-Juarez RC, Kuriakose JA, Rasko DA, Ritchie JM, Kendall MM, Slater TM, Sinha M, Luxon BA, Popov VL, Waldor MK, Sperandio V, Torres AG. CadA negatively regulates Escherichia coli O157:H7 adherence and intestinal colonization. Infect Immun. 2008 Nov; 76(11):5072-81.
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  51. Livny J, Teonadi H, Livny M, Waldor MK. High-throughput, kingdom-wide prediction and annotation of bacterial non-coding RNAs. PLoS One. 2008; 3(9):e3197.
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  52. Rasko DA, Moreira CG, Li de R, Reading NC, Ritchie JM, Waldor MK, Williams N, Taussig R, Wei S, Roth M, Hughes DT, Huntley JF, Fina MW, Falck JR, Sperandio V. Targeting QseC signaling and virulence for antibiotic development. Science. 2008 Aug 22; 321(5892):1078-80.
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  53. Duigou S, Yamaichi Y, Waldor MK. ATP negatively regulates the initiator protein of Vibrio cholerae chromosome II replication. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10577-82.
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  54. Shifrin Y, Peleg A, Ilan O, Nadler C, Kobi S, Baruch K, Yerushalmi G, Berdichevsky T, Altuvia S, Elgrably-Weiss M, Abe C, Knutton S, Sasakawa C, Ritchie JM, Waldor MK, Rosenshine I. Transient shielding of intimin and the type III secretion system of enterohemorrhagic and enteropathogenic Escherichia coli by a group 4 capsule. J Bacteriol. 2008 Jul; 190(14):5063-74.
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  55. Osorio CR, Marrero J, Wozniak RA, Lemos ML, Burrus V, Waldor MK. Genomic and functional analysis of ICEPdaSpa1, a fish-pathogen-derived SXT-related integrating conjugative element that can mobilize a virulence plasmid. J Bacteriol. 2008 May; 190(9):3353-61.
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  56. Ho TD, Davis BM, Ritchie JM, Waldor MK. Type 2 secretion promotes enterohemorrhagic Escherichia coli adherence and intestinal colonization. Infect Immun. 2008 May; 76(5):1858-65.
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  57. Livny J, Waldor MK. Small non-coding RNAs in bacterial pathogenesis. Virulence Mechanisms of Bacterial Pathogen (Brogden, K. A., Minion, F. C., Stanton, T. B., Zhang, Q., Nolan, L. and Wannemuehler, M. J. editors). 2008; in press.
  58. 24 Waldor MK, Keusch GT. Cholera and other vibrioses. Harrison’s Principals of Internal Medicine. 2008; in press.
  59. Ritchie JM, Brady MJ, Riley KN, Ho TD, Campellone KG, Herman IM, Donohue-Rolfe A, Tzipori S, Waldor MK, Leong JM. EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7. Cell Microbiol. 2008 Apr; 10(4):836-47.
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  60. Murphy KC, Ritchie JM, Waldor MK, Løbner-Olesen A, Marinus MG. Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7. J Bacteriol. 2008 Jan; 190(1):438-41.
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  61. Livny J, Yamaichi Y, Waldor MK. Distribution of centromere-like parS sites in bacteria: insights from comparative genomics. J Bacteriol. 2007 Dec; 189(23):8693-703.
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  62. Davis BM, Waldor MK. RNase E-dependent processing stabilizes MicX, a Vibrio cholerae sRNA. Mol Microbiol. 2007 Jul; 65(2):373-85.
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  63. Marrero J, Waldor MK. Determinants of entry exclusion within Eex and TraG are cytoplasmic. J Bacteriol. 2007 Sep; 189(17):6469-73.
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  64. Yamaichi Y, Fogel MA, McLeod SM, Hui MP, Waldor MK. Distinct centromere-like parS sites on the two chromosomes of Vibrio spp. J Bacteriol. 2007 Jul; 189(14):5314-24.
    View in: PubMed
  65. Livny J, Waldor MK. Identification of small RNAs in diverse bacterial species. Curr Opin Microbiol. 2007 Apr; 10(2):96-101.
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  66. Waldor MK, Sperandio V. Adrenergic regulation of bacterial virulence. J Infect Dis. 2007 May 1; 195(9):1248-9.
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  67. Marrero J, Waldor MK. The SXT/R391 family of integrative conjugative elements is composed of two exclusion groups. J Bacteriol. 2007 Apr; 189(8):3302-5.
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  68. Yamaichi Y, Fogel MA, Waldor MK. par genes and the pathology of chromosome loss in Vibrio cholerae. Proc Natl Acad Sci U S A. 2007 Jan 9; 104(2):630-5.
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  69. Mathur J, Davis BM, Waldor MK. Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway. Mol Microbiol. 2007 Feb; 63(3):848-58.
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  70. Ho TD, Waldor MK. Enterohemorrhagic Escherichia coli O157:H7 gal mutants are sensitive to bacteriophage P1 and defective in intestinal colonization. Infect Immun. 2007 Apr; 75(4):1661-6.
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  71. Fogel MA, Waldor MK. A dynamic, mitotic-like mechanism for bacterial chromosome segregation. Genes Dev. 2006 Dec 1; 20(23):3269-82.
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  72. Budde PP, Davis BM, Yuan J, Waldor MK. Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J Bacteriol. 2007 Jan; 189(2):491-500.
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  73. Slamti L, Livny J, Waldor MK. Global gene expression and phenotypic analysis of a Vibrio cholerae rpoH deletion mutant. J Bacteriol. 2007 Jan; 189(2):351-62.
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  74. Quinones M, Kimsey HH, Ross W, Gourse RL, Waldor MK. LexA represses CTXphi transcription by blocking access of the alpha C-terminal domain of RNA polymerase to promoter DNA. J Biol Chem. 2006 Dec 22; 281(51):39407-12.
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  75. Duigou S, Knudsen KG, Skovgaard O, Egan ES, Løbner-Olesen A, Waldor MK. Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB. J Bacteriol. 2006 Sep; 188(17):6419-24.
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  76. McLeod SM, Burrus V, Waldor MK. Requirement for Vibrio cholerae integration host factor in conjugative DNA transfer. J Bacteriol. 2006 Aug; 188(16):5704-11.
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  77. Burrus V, Quezada-Calvillo R, Marrero J, Waldor MK. SXT-related integrating conjugative element in New World Vibrio cholerae. Appl Environ Microbiol. 2006 Apr; 72(4):3054-7.
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  78. Burrus V, Marrero J, Waldor MK. The current ICE age: biology and evolution of SXT-related integrating conjugative elements. Plasmid. 2006 May; 55(3):173-83.
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  79. Petridis M, Bagdasarian M, Waldor MK, Walker E. Horizontal transfer of Shiga toxin and antibiotic resistance genes among Escherichia coli strains in house fly (Diptera: Muscidae) gut. J Med Entomol. 2006 Mar; 43(2):288-95.
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  80. Quinones M, Davis BM, Waldor MK. Activation of the Vibrio cholerae SOS response is not required for intestinal cholera toxin production or colonization. Infect Immun. 2006 Feb; 74(2):927-30.
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  81. Waldor MK. Disarming pathogens--a new approach for antibiotic development. N Engl J Med. 2006 Jan 19; 354(3):296-7.
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  82. Waldor MK. Disarming pathogens – a new approach for antibiotic development. NEJM. 2006; (354):296-97.
  83. Wagner P, Waldor MK. Bacteriophages and Bacteria Pathogenesis. The Bacteriophages (Calendar R.N., ed.). 2006; 710-24.
  84. Livny J, Brencic A, Lory S, Waldor MK. Identification of 17 Pseudomonas aeruginosa sRNAs and prediction of sRNA-encoding genes in 10 diverse pathogens using the bioinformatic tool sRNAPredict2. Nucleic Acids Res. 2006; 34(12):3484-93.
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  85. Egan ES, Duigou S, Waldor MK. Autorepression of RctB, an initiator of Vibrio cholerae chromosome II replication. J Bacteriol. 2006 Jan; 188(2):789-93.
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  86. Waldor MK, Friedman DI. Phage regulatory circuits and virulence gene expression. Curr Opin Microbiol. 2005 Aug; 8(4):459-65.
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  87. Livny J, Fogel MA, Davis BM, Waldor MK. sRNAPredict: an integrative computational approach to identify sRNAs in bacterial genomes. Nucleic Acids Res. 2005; 33(13):4096-105.
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  88. McLeod SM, Kimsey HH, Davis BM, Waldor MK. CTXphi and Vibrio cholerae: exploring a newly recognized type of phage-host cell relationship. Mol Microbiol. 2005 Jul; 57(2):347-56.
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  89. Egan ES, Fogel MA, Waldor MK. Divided genomes: negotiating the cell cycle in prokaryotes with multiple chromosomes. Mol Microbiol. 2005 Jun; 56(5):1129-38.
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  90. Marrero J, Waldor MK. Interactions between inner membrane proteins in donor and recipient cells limit conjugal DNA transfer. Dev Cell. 2005 Jun; 8(6):963-70.
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  91. Davis BM, Quinones M, Pratt J, Ding Y, Waldor MK. Characterization of the small untranslated RNA RyhB and its regulon in Vibrio cholerae. J Bacteriol. 2005 Jun; 187(12):4005-14.
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  92. Ritchie JM, Waldor MK. The locus of enterocyte effacement-encoded effector proteins all promote enterohemorrhagic Escherichia coli pathogenicity in infant rabbits. Infect Immun. 2005 Mar; 73(3):1466-74.
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  93. Quinones M, Kimsey HH, Waldor MK. LexA cleavage is required for CTX prophage induction. Mol Cell. 2005 Jan 21; 17(2):291-300.
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  94. Phage: Role in Pathogenesis and Biotechnology (M. K. Waldor, D. Friedman, and S. Adyha eds.). 2005.
  95. Fogel MA, Waldor MK. Distinct segregation dynamics of the two Vibrio cholerae chromosomes. Mol Microbiol. 2005 Jan; 55(1):125-36.
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  96. 19 Waldor MK, Keusch GT. Cholera and other vibrioses. Harrison’s Principals of Internal Medicine (Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, eds.). 2005; 909-14.
  97. Davis BD, Waldor MK. Bacteriophages linked to Vibrio cholerae pathogenesis. Phage: Role in Pathogenesis and Biotechnology (M. K. Waldor, D. Friedman, and S. Adyha eds.). 2005.
  98. McLeod SM, Waldor MK. Characterization of XerC- and XerD-dependent CTX phage integration in Vibrio cholerae. Mol Microbiol. 2004 Nov; 54(4):935-47.
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  99. Beaber JW, Waldor MK. Identification of operators and promoters that control SXT conjugative transfer. J Bacteriol. 2004 Sep; 186(17):5945-9.
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  100. Egan ES, Løbner-Olesen A, Waldor MK. Synchronous replication initiation of the two Vibrio cholerae chromosomes. Curr Biol. 2004 Jul 13; 14(13):R501-2.
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  101. Ding Y, Davis BM, Waldor MK. Hfq is essential for Vibrio cholerae virulence and downregulates sigma expression. Mol Microbiol. 2004 Jul; 53(1):345-54.
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  102. Burrus V, Waldor MK. Shaping bacterial genomes with integrative and conjugative elements. Res Microbiol. 2004 Jun; 155(5):376-86.
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  103. Mathur J, Waldor MK. The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Infect Immun. 2004 Jun; 72(6):3577-83.
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  104. Burrus V, Waldor MK. Formation of SXT tandem arrays and SXT-R391 hybrids. J Bacteriol. 2004 May; 186(9):2636-45.
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  105. Beaber JW, Hochhut B, Waldor MK. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature. 2004 Jan 1; 427(6969):72-4.
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  106. Ritchie JM, Thorpe CM, Rogers AB, Waldor MK. Critical roles for stx2, eae, and tir in enterohemorrhagic Escherichia coli-induced diarrhea and intestinal inflammation in infant rabbits. Infect Immun. 2003 Dec; 71(12):7129-39.
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  107. Sumby P, Waldor MK. Transcription of the toxin genes present within the Staphylococcal phage phiSa3ms is intimately linked with the phage's life cycle. J Bacteriol. 2003 Dec; 185(23):6841-51.
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  108. Kimsey HH, Waldor MK. The CTXphi repressor RstR binds DNA cooperatively to form tetrameric repressor-operator complexes. J Biol Chem. 2004 Jan 23; 279(4):2640-7.
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  109. Burrus V, Waldor MK. Control of SXT integration and excision. J Bacteriol. 2003 Sep; 185(17):5045-54.
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  110. Egan ES, Waldor MK. Distinct replication requirements for the two Vibrio cholerae chromosomes. Cell. 2003 Aug 22; 114(4):521-30.
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  111. Ding Y, Waldor MK. Deletion of a Vibrio cholerae ClC channel results in acid sensitivity and enhanced intestinal colonization. Infect Immun. 2003 Jul; 71(7):4197-200.
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  112. Ritchie JM, Wagner PL, Acheson DW, Waldor MK. Comparison of Shiga toxin production by hemolytic-uremic syndrome-associated and bovine-associated Shiga toxin-producing Escherichia coli isolates. Appl Environ Microbiol. 2003 Feb; 69(2):1059-66.
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  113. Davis BM, Waldor MK. Filamentous phages linked to virulence of Vibrio cholerae. Curr Opin Microbiol. 2003 Feb; 6(1):35-42.
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  114. Heilpern AJ, Waldor MK. pIIICTX, a predicted CTXphi minor coat protein, can expand the host range of coliphage fd to include Vibrio cholerae. J Bacteriol. 2003 Feb; 185(3):1037-44.
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  115. Beaber JW, Burrus V, Hochhut B, Waldor MK. Comparison of SXT and R391, two conjugative integrating elements: definition of a genetic backbone for the mobilization of resistance determinants. Cell Mol Life Sci. 2002 Dec; 59(12):2065-70.
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  116. Davis BM, Kimsey HH, Kane AV, Waldor MK. A satellite phage-encoded antirepressor induces repressor aggregation and cholera toxin gene transfer. EMBO J. 2002 Aug 15; 21(16):4240-9.
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  117. Wagner PL, Waldor MK. Bacteriophage control of bacterial virulence. Infect Immun. 2002 Aug; 70(8):3985-93.
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  118. Beaber JW, Hochhut B, Waldor MK. Genomic and functional analyses of SXT, an integrating antibiotic resistance gene transfer element derived from Vibrio cholerae. J Bacteriol. 2002 Aug; 184(15):4259-69.
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  119. Huber KE, Waldor MK. Filamentous phage integration requires the host recombinases XerC and XerD. Nature. 2002 Jun 6; 417(6889):656-9.
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  120. Boyd EF, Waldor MK. Evolutionary and functional analyses of variants of the toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae non-O1/non-O139 serogroup isolates. Microbiology. 2002 Jun; 148(Pt 6):1655-66.
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  121. Wagner PL, Livny J, Neely MN, Acheson DW, Friedman DI, Waldor MK. Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli. Mol Microbiol. 2002 May; 44(4):957-70.
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  122. 17 Waldor MK, Zychlinsky A. Host-pathogen interactions: bacteria. Microbes and their hosts: mutual interactions. Current Opinion in Microbiology. 2002; (5):17-19.
  123. Davis BD, Waldor MK. Mobile genetic elements and bacterial pathogenesis. Mobile DNAII (N. L. Craig et. al.eds.). 2002; 1040-59.
  124. Hochhut B, Lotfi Y, Mazel D, Faruque SM, Woodgate R, Waldor MK. Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins. Antimicrob Agents Chemother. 2001 Nov; 45(11):2991-3000.
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  125. Moyer KE, Kimsey HH, Waldor MK. Evidence for a rolling-circle mechanism of phage DNA synthesis from both replicative and integrated forms of CTXphi. Mol Microbiol. 2001 Jul; 41(2):311-23.
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  126. Wagner PL, Neely MN, Zhang X, Acheson DW, Waldor MK, Friedman DI. Role for a phage promoter in Shiga toxin 2 expression from a pathogenic Escherichia coli strain. J Bacteriol. 2001 Mar; 183(6):2081-5.
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  127. Wagner PL, Acheson DW, Waldor MK. Human neutrophils and their products induce Shiga toxin production by enterohemorrhagic Escherichia coli. Infect Immun. 2001 Mar; 69(3):1934-7.
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  128. Hochhut B, Beaber JW, Woodgate R, Waldor MK. Formation of chromosomal tandem arrays of the SXT element and R391, two conjugative chromosomally integrating elements that share an attachment site. J Bacteriol. 2001 Feb; 183(4):1124-32.
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  129. Keusch GT, Waldor MK. Cholera and other vibrioses. Harrison’s Principals of Internal Medicine 15th Edition (Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, eds.). 2001; 980-86.
  130. Davis BM, Moyer KE, Boyd EF, Waldor MK. CTX prophages in classical biotype Vibrio cholerae: functional phage genes but dysfunctional phage genomes. J Bacteriol. 2000 Dec; 182(24):6992-8.
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  131. Boyd EF, Heilpern AJ, Waldor MK. Molecular analyses of a putative CTXphi precursor and evidence for independent acquisition of distinct CTX(phi)s by toxigenic Vibrio cholerae. J Bacteriol. 2000 Oct; 182(19):5530-8.
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  132. Waldor MK, RayChaudhuri D. Treasure trove for cholera research. Nature. 2000 Aug 3; 406(6795):469-70.
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  133. Faruque SM, Rahman MM, Waldor MK, Sack DA. Sunlight-induced propagation of the lysogenic phage encoding cholera toxin. Infect Immun. 2000 Aug; 68(8):4795-801.
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  134. Davis BM, Waldor MK. CTXphi contains a hybrid genome derived from tandemly integrated elements. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8572-7.
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  135. Cevallos AM, Zhang X, Waldor MK, Jaison S, Zhou X, Tzipori S, Neutra MR, Ward HD. Molecular cloning and expression of a gene encoding Cryptosporidium parvum glycoproteins gp40 and gp15. Infect Immun. 2000 Jul; 68(7):4108-16.
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  136. Davis BM, Lawson EH, Sandkvist M, Ali A, Sozhamannan S, Waldor MK. Convergence of the secretory pathways for cholera toxin and the filamentous phage, CTXphi. Science. 2000 Apr 14; 288(5464):333-5.
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  137. Hochhut B, Marrero J, Waldor MK. Mobilization of plasmids and chromosomal DNA mediated by the SXT element, a constin found in Vibrio cholerae O139. J Bacteriol. 2000 Apr; 182(7):2043-7.
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  138. Heilpern AJ, Waldor MK. CTXphi infection of Vibrio cholerae requires the tolQRA gene products. J Bacteriol. 2000 Mar; 182(6):1739-47.
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  139. Boyd EF, Moyer KE, Shi L, Waldor MK. Infectious CTXPhi and the vibrio pathogenicity island prophage in Vibrio mimicus: evidence for recent horizontal transfer between V. mimicus and V. cholerae. Infect Immun. 2000 Mar; 68(3):1507-13.
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  140. Zhang X, McDaniel AD, Wolf LE, Keusch GT, Waldor MK, Acheson DW. Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice. J Infect Dis. 2000 Feb; 181(2):664-70.
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  141. Lee SH, Hava DL, Waldor MK, Camilli A. Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infection. Cell. 1999 Dec 10; 99(6):625-34.
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  142. Wagner PL, Acheson DW, Waldor MK. Isogenic lysogens of diverse shiga toxin 2-encoding bacteriophages produce markedly different amounts of shiga toxin. Infect Immun. 1999 Dec; 67(12):6710-4.
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  143. Davis BM, Kimsey HH, Chang W, Waldor MK. The Vibrio cholerae O139 Calcutta bacteriophage CTXphi is infectious and encodes a novel repressor. J Bacteriol. 1999 Nov; 181(21):6779-87.
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  144. Boyd EF, Waldor MK. Alternative mechanism of cholera toxin acquisition by Vibrio cholerae: generalized transduction of CTXPhi by bacteriophage CP-T1. Infect Immun. 1999 Nov; 67(11):5898-905.
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  145. Angelichio MJ, Spector J, Waldor MK, Camilli A. Vibrio cholerae intestinal population dynamics in the suckling mouse model of infection. Infect Immun. 1999 Aug; 67(8):3733-9.
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  146. Hochhut B, Waldor MK. Site-specific integration of the conjugal Vibrio cholerae SXT element into prfC. Mol Microbiol. 1999 Apr; 32(1):99-110.
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  147. Hochhut B, Waldor MK. Transfer of antibiotic resistance genes in Vibrio cholerae by a novel genetic element. Proceedings of the U.S.-Korea Forum on Emerging Infectious Diseases. 1999; 118-25.
  148. Meno Y, Waldor MK, Mekalanos JJ, Amako K. Morphological and physical characterization of the capsular layer of Vibrio cholerae O139. Arch Microbiol. 1998 Oct; 170(5):339-44.
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  149. Acheson DW, Reidl J, Zhang X, Keusch GT, Mekalanos JJ, Waldor MK. In vivo transduction with shiga toxin 1-encoding phage. Infect Immun. 1998 Sep; 66(9):4496-8.
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  150. Kimsey HH, Waldor MK. Vibrio cholerae hemagglutinin/protease inactivates CTXphi. Infect Immun. 1998 Sep; 66(9):4025-9.
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  151. Kimsey HH, Nair GB, Ghosh A, Waldor MK. Diverse CTXphis and evolution of new pathogenic Vibrio cholerae. Lancet. 1998 Aug 8; 352(9126):457-8.
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  152. Waldor MK. Bacteriophage biology and bacterial virulence. Trends Microbiol. 1998 Aug; 6(8):295-7.
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  153. Kimsey HH, Waldor MK. CTXphi immunity: application in the development of cholera vaccines. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):7035-9.
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  154. Rubin EJ, Lin W, Mekalanos JJ, Waldor MK. Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage. Mol Microbiol. 1998 Jun; 28(6):1247-54.
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  155. Calia KE, Waldor MK, Calderwood SB. Use of representational difference analysis to identify genomic differences between pathogenic strains of Vibrio cholerae. Infect Immun. 1998 Feb; 66(2):849-52.
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  156. Waldor MK, Lazar S, Kimsey H, Williams J, Mekalanos JJ. CTXφ: A Novel Filamentous Phage Encoding Cholera Toxin. Bacterial Protein Toxins Zent.bl. Bakteriol. Suppl. 29 (J. Hacker et al, eds.). 1998; 363-71.
  157. Lazar S, Waldor MK. ToxR-independent expression of cholera toxin from the replicative form of CTXphi. Infect Immun. 1998 Jan; 66(1):394-7.
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  158. Rubin EJ, Waldor MK, Mekalanos JJ. Mobile genetic elements and the evolution of new epidemic strains of Vibrio cholerae. Emerging Infections (R. M. Krause, ed.). 1998; 147-61.
  159. Mekalanos JJ, Rubin EJ, Waldor MK. Cholera: molecular basis for emergence and pathogenesis. FEMS Immunol Med Microbiol. 1997 Aug; 18(4):241-8.
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  160. Waldor MK, Rubin EJ, Pearson GD, Kimsey H, Mekalanos JJ. Regulation, replication, and integration functions of the Vibrio cholerae CTXphi are encoded by region RS2. Mol Microbiol. 1997 Jun; 24(5):917-26.
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  161. Waldor MK, Tschäpe H, Mekalanos JJ. A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139. J Bacteriol. 1996 Jul; 178(14):4157-65.
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  162. Waldor MK, Mekalanos JJ. Lysogenic conversion by a filamentous phage encoding cholera toxin. Science. 1996 Jun 28; 272(5270):1910-4.
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  163. Waldor MK, Mekalanos JJ. Progress toward safe oral live-attenuated cholera vaccines. Mucosal Vaccines (H. Kiyono, P. Ogra, and J. McGhee, eds.). 1996; 229-38.
  164. Waldor MK, Mekalanos JJ. . Vibrio cholerae: molecular pathogenesis, immune response, and vaccine development. Enteric Infections and Immune Responses (H. Friedman, L. Paradise and M. Bendinelli, eds.). 1996; 37-56.
  165. Mekalanos JJ, Waldor MK, Gardel CL, Killeen KP, Beattie DT, Adams JM, Hyman T, Spriggs DR, Coster TS, Kenner JR, Trofa A, Taylor D, Sadoff JC. . Construction and characterization of live, attenuated Vibrio cholerae El Tor O1 and O139 vaccines. Vaccines 96: Molecular approaches to the control of infectious diseases (F. Brown, E. Norrby, D. Burton, and J. Mekalanos, eds.). 1996; 103-9.
  166. Coster TS, Killeen KP, Waldor MK, Beattie DT, Spriggs DR, Kenner JR, Trofa A, Sadoff JC, Mekalanos JJ, Taylor DN. Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae O139 vaccine prototype. Lancet. 1995 Apr 15; 345(8955):949-52.
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  167. Mekalanos JJ, Waldor MK, Gardel CL, Coster TS, Kenner J, Killeen K, Beattie D, Trofa A, Taylor D, Sadoff JC. . Live cholera vaccines: perspectives on their construction and safety. 1995; 93:255-62.
  168. Waldor MK, Colwell R, Mekalanos JJ. The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants. Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24):11388-92.
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  169. Waldor MK, Mekalanos JJ. Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype. J Infect Dis. 1994 Aug; 170(2):278-83.
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  170. Waldor MK, Mekalanos JJ. Vibrio cholerae O139 specific gene sequences. Lancet. 1994 May 28; 343(8909):1366.
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  171. Waldor MK, Mekalanos JJ. ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera. Infect Immun. 1994 Jan; 62(1):72-8.
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  172. Mahan MJ, Slauch JM, Hanna PC, Camilli AC, Tobias JW, Waldor MK, Mekalanos JJ. Selection for bacterial virulence genes that are specifically induced in host tissues: The hunt for virulence factors. Infectious Agents and Diseases Volume II (Falkow S ed.). 1994; 2:263-8.
  173. Mahan MJ, Slauch JM, Hanna PC, Camilli A, Tobias JW, Waldor MK, Mekalanos JJ. Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors. Infect Agents Dis. 1993 Aug; 2(4):263-8.
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  174. Waldor MK, Mekalanos JJ. Molecular analysis of virulence determinants carried by the Bengal strains of Vibrio cholerae O139 and construction of live vaccine prototypes. 29th Joint conference on cholera and related diarrheal diseases; U. S. - Japan Cooperative Medical Science Program. 1993; 42-6.
  175. Waldor MK, Wilson B, Swartz M. Cellulitis caused by Legionella pneumophila. Clin Infect Dis. 1993 Jan; 16(1):51-3.
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  176. Waldor M, Roberts D, Kazanjian P. In utero infection due to Pasteurella multocida in the first trimester of pregnancy: case report and review. Clin Infect Dis. 1992 Feb; 14(2):497-500.
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  177. Waldor MK. Treatment of autoimmune disease with monoclonal anti-CD4 antibodies. Immunol Ser. 1989; 45:573-86.
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  178. Waldor MK. Treatment of autoimmune disease with monoclonal anti-CD4 antibodies. Cell Surface Antigen Thy-1: Immunology, Neurology and Therapeutic Applications (A. Reif, M Schlesinger, eds.). 1989; 573-86.
  179. Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell. 1988 Jul 15; 54(2):263-73.
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  180. Zamvil SS, Mitchell DJ, Lee NE, Moore AC, Waldor MK, Sakai K, Rothbard JB, McDevitt HO, Steinman L, Acha-Orbea H. Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis. J Exp Med. 1988 May 1; 167(5):1586-96.
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  181. Waldor MK, Mitchell D, Kipps TJ, Herzenberg LA, Steinman L. Importance of immunoglobulin isotype in therapy of experimental autoimmune encephalomyelitis with monoclonal anti-CD4 antibody. J Immunol. 1987 Dec 1; 139(11):3660-4.
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  182. Vollmer TL, Waldor MK, Steinman L, Conley FK. Depletion of T-4+ lymphocytes with monoclonal antibody reactivates toxoplasmosis in the central nervous system: a model of superinfection in AIDS. J Immunol. 1987 Jun 1; 138(11):3737-41.
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  183. Waldor MK, O'Hearn M, Sriram S, Steinman L. Treatment of experimental autoimmune myasthenia gravis with monoclonal antibodies to immune response gene products. Ann N Y Acad Sci. 1987; 505:655-68.
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  184. Steinman L, Zamvil S, O'Hearn M, Sriram S, Mitchell D, Waldor MK. Experiences with anti-Ia therapy in the mouse the monkey and applications to human protocols. Anti-Ia Antibodies in the Treatment of Autoimmune Disease (J. Broche, J. Clot, and J. Sany, eds.). 1986; 109-28.
  185. Steinman L, Waldor MK, Zamvil SS, Lim M, Herzenberg L, Herzenberg L, McDevitt HO, Mitchell D, Sriram S. Therapy of autoimmune diseases with antibody to immune response gene products or to T-cell surface markers. Ann N Y Acad Sci. 1986; 475:274-84.
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  186. Waldor MK, Sriram S, Hardy R, Herzenberg LA, Herzenberg LA, Lanier L, Lim M, Steinman L. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science. 1985 Jan 25; 227(4685):415-7.
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  187. Steinman L, Trotter J, Waldor M, Sriram S. . New approaches to therapy of autoimmune disease. Concepts in Immunopathology (J. Cruse and R. Lewis, eds.). 1985; 1:85-95.
  188. Steinman L, Trotter J, Waldor M, Sriram S. New approaches to therapy of autoimmune disease. Concepts Immunopathol. 1985; 1:85-95.
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  189. Waldor MK, Hardy RR, Hayakawa K, Steinman L, Herzenberg LA, Herzenberg LA. Disappearance and reappearance of B cells after in vivo treatment with monoclonal anti-I-A antibodies. Proc Natl Acad Sci U S A. 1984 May; 81(9):2855-8.
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  190. Steinman L, Schwartz G, Waldor M, O'Hearn M, Lim M, Sriram S. Gene specific and antigen specific strategies for the induction of suppressor T cells to myelin basic protein. Prog Clin Biol Res. 1984; 146:393-7.
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  191. Steinman L, Schwartz G, Waldor M, O'Hearn M, Lim M, Sriram S. Gene specific and antigen specific strategies for the induction of suppressor T cells to myelin basic protein. Experimental Allergic Encephalomyelitis: A Useful Model for Multiple Sclerosis. (E. Alvord, M. Kies, A. Suckling, eds.). 1984; 393-97.
  192. Waldor MK, Sriram S, McDevitt HO, Steinman L. In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor. Proc Natl Acad Sci U S A. 1983 May; 80(9):2713-7.
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