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Yukako Yagi, PH.D.

TitleAssistant Professor of Pathology
InstitutionMassachusetts General Hospital
DepartmentPathology
AddressMassachusetts General Hospital
Pathology, 101 Merrimac 820
101 Merrimac Street
Boston MA 02114
Phone617/643-5162
Fax617/643-7901

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tang R, Buckley JM, Fernandez L, Coopey S, Aftreth O, Michaelson J, Saksena M, Lei L, Specht M, Gadd M, Yagi Y, Rafferty E, Brachtel E, Smith BL. Micro-computed tomography (Micro-CT): a novel approach for intraoperative breast cancer specimen imaging. Breast Cancer Res Treat. 2013 Jun; 139(2):311-6.
    View in: PubMed
  2. Onozato ML, Kovach AE, Yeap BY, Morales-Oyarvide V, Klepeis VE, Tammireddy S, Heist RS, Mark EJ, Dias-Santagata D, Iafrate AJ, Yagi Y, Mino-Kenudson M. Tumor Islands in Resected Early-stage Lung Adenocarcinomas are Associated With Unique Clinicopathologic and Molecular Characteristics and Worse Prognosis. Am J Surg Pathol. 2013 Feb; 37(2):287-94.
    View in: PubMed
  3. Pantanowitz L, Szymas J, Yagi Y, Wilbur D. Whole slide imaging for educational purposes. J Pathol Inform. 2012; 3:46.
    View in: PubMed
  4. Carignan CS, Yagi Y. Optical endomicroscopy and the road to real-time, in vivo pathology: present and future. Diagn Pathol. 2012; 7:98.
    View in: PubMed
  5. Nishino M, Klepeis VE, Yeap BY, Bergethon K, Morales-Oyarvide V, Dias-Santagata D, Yagi Y, Mark EJ, Iafrate AJ, Mino-Kenudson M. Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas. Mod Pathol. 2012 Nov; 25(11):1462-72.
    View in: PubMed
  6. Bautista PA, Yagi Y. Digital simulation of staining in histopathology multispectral images: enhancement and linear transformation of spectral transmittance. J Biomed Opt. 2012 May; 17(5):056013.
    View in: PubMed
  7. Yagi Y, Pantanowitz L. Comment on "Quality evaluation of microscopy and scanned histological images for diagnostic purposes": Are scanners better than microscopes? J Pathol Inform. 2012; 3:14.
    View in: PubMed
  8. Gilbertson JR, McClintock DS, Lee RE, Onozato M, Kuo FC, Beckwith BA, Yagi Y, Dighe AS, Gudewicz TM, Le LP, Wilbur DC, Kim JY, Brodsky VB, Black-Schaffer S. Clinical fellowship training in pathology informatics: A program description. J Pathol Inform. 2012; 3:11.
    View in: PubMed
  9. Hashimoto N, Bautista PA, Yamaguchi M, Ohyama N, Yagi Y. Referenceless image quality evaluation for whole slide imaging. J Pathol Inform. 2012; 3:9.
    View in: PubMed
  10. Onozato ML, Klepeis VE, Yagi Y, Mino-Kenudson M. A Role of Three-Dimensional (3D) Reconstruction in the Classification of Lung Adenocarcinoma. Stud Health Technol Inform. 2012; 179:250-6.
    View in: PubMed
  11. Hipp J, Monaco J, Kunju LP, Cheng J, Yagi Y, Rodriguez-Canales J, Emmert-Buck MR, Hewitt S, Feldman MD, Tomaszewski JE, Toner M, Tompkins RG, Flotte T, Lucas D, Gilbertson JR, Madabhushi A, Balis U. Integration of architectural and cytologic driven image algorithms for prostate adenocarcinoma identification. Anal Cell Pathol (Amst). 2012; 35(4):251-65.
    View in: PubMed
  12. Bautista PA, Yagi Y. Multispectral enhancement method to increase the visual differences of tissue structures in stained histopathology images. Anal Cell Pathol (Amst). 2012 Jan 1; 35(5):407-20.
    View in: PubMed
  13. Yagi Y, Rojo MG, Kayser K, Kayser G, Laurinavicius A, Della Mea V, Levy B, Klossa J, Tearney G, Szymas J, Tsuchihashi Y, Têtu B. The First Congress of the International Academy of Digital Pathology: digital pathology comes of age. Anal Cell Pathol (Amst). 2012; 35(1):1-2.
    View in: PubMed
  14. Sharma A, Bautista P, Yagi Y. Balancing image quality and compression factor for special stains whole slide images. Anal Cell Pathol (Amst). 2012; 35(2):101-6.
    View in: PubMed
  15. Ayad E, Yagi Y. Virtual microscopy beyond the pyramids, applications of WSI in Cairo University for E-education & telepathology. Anal Cell Pathol (Amst). 2012; 35(2):93-5.
    View in: PubMed
  16. Malon C, Brachtel E, Cosatto E, Graf HP, Kurata A, Kuroda M, Meyer JS, Saito A, Wu S, Yagi Y. Mitotic figure recognition: agreement among pathologists and computerized detector. Anal Cell Pathol (Amst). 2012; 35(2):97-100.
    View in: PubMed
  17. Bautista PA, Yagi Y. Multispectral enhancement towards digital staining. Anal Cell Pathol (Amst). 2012; 35(1):51-5.
    View in: PubMed
  18. Yagi Y, Yoshioka S, Kyusojin H, Onozato M, Mizutani Y, Osato K, Yada H, Mark EJ, Frosch MP, Louis DN. An ultra-high speed whole slide image viewing system. Stud Health Technol Inform. 2012; 179:239-49.
    View in: PubMed
  19. Yagi Y, Yoshioka S, Kyusojin H, Onozato M, Mizutani Y, Osato K, Yada H, Mark EJ, Frosch MP, Louis DN. An ultra-high speed whole slide image viewing system. Anal Cell Pathol (Amst). 2012; 35(1):65-73.
    View in: PubMed
  20. Onozato ML, Hammond S, Merren M, Yagi Y. Evaluation of a completely automated tissue-sectioning machine for paraffin blocks. Stud Health Technol Inform. 2012; 179:233-8.
    View in: PubMed
  21. Onozato ML, Klepeis VE, Yagi Y, Mino-Kenudson M. A role of three-dimensional (3D)-reconstruction in the classification of lung adenocarcinoma. Anal Cell Pathol (Amst). 2012; 35(2):79-84.
    View in: PubMed
  22. Brachtel E, Yagi Y. Digital imaging in pathology - current applications and challenges. J Biophotonics. 2012 Apr; 5(4):327-35.
    View in: PubMed
  23. Hipp J, Cheng J, Pantanowitz L, Hewitt S, Yagi Y, Monaco J, Madabhushi A, Rodriguez-Canales J, Hanson J, Roy-Chowdhuri S, Filie AC, Feldman MD, Tomaszewski JE, Shih NN, Brodsky V, Giaccone G, Emmert-Buck MR, Balis UJ. Image microarrays (IMA): Digital pathology's missing tool. J Pathol Inform. 2011; 2:47.
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  24. Lee RE, McClintock DS, Laver NM, Yagi Y. Evaluation and optimization for liquid-based preparation cytology in whole slide imaging. J Pathol Inform. 2011; 2:46.
    View in: PubMed
  25. Yoo H, Kang D, Katz AJ, Lauwers GY, Nishioka NS, Yagi Y, Tanpowpong P, Namati J, Bouma BE, Tearney GJ. Reflectance confocal microscopy for the diagnosis of eosinophilic esophagitis: a pilot study conducted on biopsy specimens. Gastrointest Endosc. 2011 Nov; 74(5):992-1000.
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  26. Onozato ML, Hammond S, Merren M, Yagi Y. Evaluation of a completely automated tissue-sectioning machine for paraffin blocks. J Clin Pathol. 2013 Feb; 66(2):151-4.
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  27. Hariri LP, Mino-Kenudson M, Shea B, Digumarthy S, Onozato M, Yagi Y, Fraire AE, Matsubara O, Mark EJ. Distinct histopathology of acute onset or abrupt exacerbation of hypersensitivity pneumonitis. Hum Pathol. 2012 May; 43(5):660-8.
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  28. Liu L, Gardecki JA, Nadkarni SK, Toussaint JD, Yagi Y, Bouma BE, Tearney GJ. Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography. Nat Med. 2011 Aug; 17(8):1010-4.
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  29. Hipp J, Flotte T, Monaco J, Cheng J, Madabhushi A, Yagi Y, Rodriguez-Canales J, Emmert-Buck M, Dugan MC, Hewitt S, Toner M, Tompkins RG, Lucas D, Gilbertson JR, Balis UJ. Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess. J Pathol Inform. 2011; 2:25.
    View in: PubMed
  30. Yagi Y. Color standardization and optimization in whole slide imaging. Diagn Pathol. 2011; 6 Suppl 1:S15.
    View in: PubMed
  31. Bautista PA, Yagi Y. Localization of eosinophilic esophagitis from H&E stained images using multispectral imaging. Diagn Pathol. 2011; 6 Suppl 1:S2.
    View in: PubMed
  32. Abstracts of the 1st Congress of the International Academy of Digital Pathology, August 3–5, 2011, Quebec City, Canada. Anal Cell Pathol (Amst). 2011; 34(4):169-203.
    View in: PubMed
  33. Hipp J, Cheng J, Daignault S, Sica J, Dugan MC, Lucas D, Yagi Y, Hewitt S, Balis UJ. Automated area calculation of histopathologic features using SIVQ. Anal Cell Pathol (Amst). 2011; 34(5):265-75.
    View in: PubMed
  34. Bautista PA, Yagi Y. Digital staining for histopathology multispectral images by the combined application of spectral enhancement and spectral transformation. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:8013-6.
    View in: PubMed
  35. Bautista PA, Yagi Y. Improving the visualization and detection of tissue folds in whole slide images through color enhancement. J Pathol Inform. 2010; 1:25.
    View in: PubMed
  36. Yamashiro K, Taira K, Matsubayashi S, Azuma M, Okuyama D, Nakajima M, Takeda H, Suzuki H, Kawamura N, Wakao F, Yagi Y. Comparison between a traditional single still image and a multiframe video image along the z-axis of the same microscopic field of interest in cytology: Which does contribute to telecytology? Diagn Cytopathol. 2009 Oct; 37(10):727-31.
    View in: PubMed
  37. Weinstein RS, Graham AR, Richter LC, Barker GP, Krupinski EA, Lopez AM, Erps KA, Bhattacharyya AK, Yagi Y, Gilbertson JR. Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol. 2009 Aug; 40(8):1057-69.
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  38. Bautista PA, Yagi Y. Detection of tissue folds in whole slide images. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:3669-72.
    View in: PubMed
  39. Yagi Y, Gilbertson JR. A relationship between slide quality and image quality in whole slide imaging (WSI). Diagn Pathol. 2008; 3 Suppl 1:S12.
    View in: PubMed
  40. Gilbertson J, Yagi Y. Histology, imaging and new diagnostic work-flows in pathology. Diagn Pathol. 2008; 3 Suppl 1:S14.
    View in: PubMed
  41. Yagi Y, Gilbertson JR. The importance of optical optimization in whole slide imaging (WSI) and digital pathology imaging. Diagn Pathol. 2008; 3 Suppl 1:S1.
    View in: PubMed
  42. Murata N, Haruyama J, Reppert J, Rao AM, Koretsune T, Saito S, Matsudaira M, Yagi Y. Superconductivity in thin films of boron-doped carbon nanotubes. Phys Rev Lett. 2008 Jul 11; 101(2):027002.
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  43. Horbinski C, Fine JL, Medina-Flores R, Yagi Y, Wiley CA. Telepathology for intraoperative neuropathologic consultations at an academic medical center: a 5-year report. J Neuropathol Exp Neurol. 2007 Aug; 66(8):750-9.
    View in: PubMed
  44. Gilbertson JR, Ho J, Anthony L, Jukic DM, Yagi Y, Parwani AV. Primary histologic diagnosis using automated whole slide imaging: a validation study. BMC Clin Pathol. 2006; 6:4.
    View in: PubMed
  45. Ho J, Parwani AV, Jukic DM, Yagi Y, Anthony L, Gilbertson JR. Use of whole slide imaging in surgical pathology quality assurance: design and pilot validation studies. Hum Pathol. 2006 Mar; 37(3):322-31.
    View in: PubMed
  46. Bautista PA, Abe T, Yamaguchi M, Yagi Y, Ohyama N. Digital staining for multispectral images of pathological tissue specimens based on combined classification of spectral transmittance. Comput Med Imaging Graph. 2005 Dec; 29(8):649-57.
    View in: PubMed
  47. Yagi Y, Gilbertson JR. Digital imaging in pathology: the case for standardization. J Telemed Telecare. 2005; 11(3):109-16.
    View in: PubMed
  48. Yagi Y, Ahmed I, Gross W, Becich MJ, Demetris AJ, Wells A, Wiley CA, Michalopoulos GK, Yousem SA, Barnes B, Gilbertson JR. Webcasting pathology department conferences in a geographically distributed medical center. Hum Pathol. 2004 Jul; 35(7):790-7.
    View in: PubMed
  49. Zhao Y, Yagi Y, Nakajima I, Juzoji H. IP telephony--new horizon for telemedicine and e-health. J Med Syst. 2002 Aug; 26(4):277-83.
    View in: PubMed
  50. Minervini MI, Yagi Y, Marino IR, Lawson A, Nalesnik M, Randhawa P, Wu T, Fung JJ, Demetris A. Development and experience with an integrated system for transplantation telepathology. Hum Pathol. 2001 Dec; 32(12):1334-43.
    View in: PubMed
  51. Yagi Y. Telepathology support for the Mediterranean Institute for Transplantation and Advanced Specialized Therapies. Telemed Today. 2000 Jun-Jul; 8(3):6, 16-7.
    View in: PubMed
  52. Landman A, Yagi Y, Gilbertson J, Dawson R, Marchevsky A, Becich MJ. Prototype Web-based continuing medical education using FlashPix images. Proc AMIA Symp. 2000; 462-6.
    View in: PubMed
  53. Nawada M, Gotoh K, Yagi Y, Ohshima S, Yamamoto N, Deguchi F, Sawa T, Tanaka H, Yamaguchi M, Uemura H, et al. Extravascular lung water measured with 99mTc-RBC and 99mTc-DTPA is increased in left-sided heart failure. Ann Nucl Med. 1993 May; 7(2):87-95.
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  54. Saku T, Shibata Y, Cheng J, Okabe H, Ikari N, Yagi Y. Autoantibodies to keratin in Sjögren's syndrome. J Oral Pathol Med. 1990 Jan; 19(1):45-8.
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  55. Yagi Y, Takeda H, Kasagi Y, Hino T, Yokoyama M, Wada J. [Four cases of one stage operation for funnel chest with heart disease (author's transl)]. Nihon Kyobu Geka Gakkai Zasshi. 1981 Mar; 29(3):427-35.
    View in: PubMed
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