Mary Rose Loeken, PH.D.
|Title||Associate Professor of Medicine (Physiology)|
|Institution||Joslin Diabetes Center|
|Address||Joslin Diabetes Center|
One Joslin Place
Boston MA 02215
Available: 01/02/12, Expires: 12/31/15
Pax3 is a member of a family of developmental regulators that are expressed in a tissue-specific fashion during embryonic development. Pax3 is required for development of the neural tube, neural crest, and skeletal muscle. Expression of Pax3 is regulated by energy metabolism. Therefore, excess glucose metabolism, such as occurs during diabetic pregnancy, inhibits expression of Pax3 and can lead to malformation of Pax3-dependent structures, especially neural tube defects. The focus of the research in the Loeken lab is to understand how Pax3 is regulated by energy metabolism, and how Pax3 regulates embryonic development.
Student projects will employ embryonic stem cells (mouse and human) that can be differentiated to express Pax3, and mouse strains carrying mutant Pax3 alleles. Experiments will investigate:
1. Chromatin structure (histone methylation and acetylation patterns and DNA methylation) that regulates Pax3 expression, and how it is affected by energy metabolism.
2. Regulation of post-translational modification and turnover of p53 tumor suppressor protein by Pax3.
3. Regulation of glycolytic and oxidative fuel metabolism by Pax3 and p53.
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