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Last Name
Institution

Paul Denney Allen, Ph.D., M.D.

TitleProfessor of Anaesthesia, Emeritus
InstitutionBrigham and Women's Hospital
DepartmentEmeritus
AddressBrigham and Women's Hospital
Anaesthesia
75 Francis St
Boston MA 02115
Phone617/732-7334
Fax617/732-6927

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kashiyama T, Murayama T, Suzuki E, Allen PD, Ogawa Y. Frog alpha- and beta-ryanodine receptors provide distinct intracellular Ca2+ signals in a myogenic cell line. PLoS One. 2010; 5(7):e11526.
    View in: PubMed
  2. Feng W, Cherednichenko G, Ward CW, Padilla IT, Cabrales E, Lopez JR, Eltit JM, Allen PD, Pessah IN. Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1). Biochem Pharmacol. 2010 Aug 15; 80(4):512-21.
    View in: PubMed
  3. Bannister RA, Estève E, Eltit JM, Pessah IN, Allen PD, López JR, Beam KG. A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels. J Gen Physiol. 2010 Jun; 135(6):629-40.
    View in: PubMed
  4. Estève E, Eltit JM, Bannister RA, Liu K, Pessah IN, Beam KG, Allen PD, López JR. A malignant hyperthermia-inducing mutation in RYR1 (R163C): alterations in Ca2+ entry, release, and retrograde signaling to the DHPR. J Gen Physiol. 2010 Jun; 135(6):619-28.
    View in: PubMed
  5. Westerman KA, Penvose A, Yang Z, Allen PD, Vacanti CA. Adult muscle 'stem' cells can be sustained in culture as free-floating myospheres. Exp Cell Res. 2010 Jul 15; 316(12):1966-76.
    View in: PubMed
  6. Eltit JM, Yang T, Li H, Molinski TF, Pessah IN, Allen PD, Lopez JR. RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes. J Biol Chem. 2010 Apr 30; 285(18):13781-7.
    View in: PubMed
  7. Salgado DM, Eltit JM, Mansfield K, Panqueba C, Castro D, Vega MR, Xhaja K, Schmidt D, Martin KJ, Allen PD, Rodriguez JA, Dinsmore JH, López JR, Bosch I. Heart and skeletal muscle are targets of dengue virus infection. Pediatr Infect Dis J. 2010 Mar; 29(3):238-42.
    View in: PubMed
  8. Allen PD, Eddins DA. Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss. Hear Res. 2010 Jun 1; 264(1-2):10-20.
    View in: PubMed
  9. Allen PD. Triadin, not essential, but useful. J Physiol. 2009 Jul 1; 587(Pt 13):3123-4.
    View in: PubMed
  10. Chopra N, Yang T, Asghari P, Moore ED, Huke S, Akin B, Cattolica RA, Perez CF, Hlaing T, Knollmann-Ritschel BE, Jones LR, Pessah IN, Allen PD, Franzini-Armstrong C, Knollmann BC. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009 May 5; 106(18):7636-41.
    View in: PubMed
  11. Samsó M, Feng W, Pessah IN, Allen PD. Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol. 2009 Apr 14; 7(4):e85.
    View in: PubMed
  12. Woo JS, Kim do H, Allen PD, Lee EH. TRPC3-interacting triadic proteins in skeletal muscle. Biochem J. 2008 Apr 15; 411(2):399-405.
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  13. Gach MP, Cherednichenko G, Haarmann C, Lopez JR, Beam KG, Pessah IN, Franzini-Armstrong C, Allen PD. Alpha2delta1 dihydropyridine receptor subunit is a critical element for excitation-coupled calcium entry but not for formation of tetrads in skeletal myotubes. Biophys J. 2008 Apr 15; 94(8):3023-34.
    View in: PubMed
  14. Cherednichenko G, Ward CW, Feng W, Cabrales E, Michaelson L, Samso M, López JR, Allen PD, Pessah IN. Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene. Mol Pharmacol. 2008 Apr; 73(4):1203-12.
    View in: PubMed
  15. Voss AA, Allen PD, Pessah IN, Perez CF. Allosterically coupled calcium and magnesium binding sites are unmasked by ryanodine receptor chimeras. Biochem Biophys Res Commun. 2008 Feb 22; 366(4):988-93.
    View in: PubMed
  16. Shen X, Franzini-Armstrong C, Lopez JR, Jones LR, Kobayashi YM, Wang Y, Kerrick WG, Caswell AH, Potter JD, Miller T, Allen PD, Perez CF. Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle. J Biol Chem. 2007 Dec 28; 282(52):37864-74.
    View in: PubMed
  17. Lee EH, Allen PD. Homo-dimerization of RyR1 C-terminus via charged residues in random coils or in an alpha-helix. Exp Mol Med. 2007 Oct 31; 39(5):594-602.
    View in: PubMed
  18. Yang T, Allen PD, Pessah IN, Lopez JR. Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations. J Biol Chem. 2007 Dec 28; 282(52):37471-8.
    View in: PubMed
  19. Fritz N, Morel JL, Jeyakumar LH, Fleischer S, Allen PD, Mironneau J, Macrez N. RyR1-specific requirement for depolarization-induced Ca2+ sparks in urinary bladder smooth muscle. J Cell Sci. 2007 Nov 1; 120(Pt 21):3784-91.
    View in: PubMed
  20. Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B, Pu WT. Altered microRNA expression in human heart disease. Physiol Genomics. 2007 Nov 14; 31(3):367-73.
    View in: PubMed
  21. Feng W, Tu J, Pouliquin P, Cabrales E, Shen X, Dulhunty A, Worley PF, Allen PD, Pessah IN. Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1. Cell Calcium. 2008 Mar; 43(3):307-14.
    View in: PubMed
  22. Paolini C, Quarta M, Nori A, Boncompagni S, Canato M, Volpe P, Allen PD, Reggiani C, Protasi F. Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1. J Physiol. 2007 Sep 1; 583(Pt 2):767-84.
    View in: PubMed
  23. Phimister AJ, Lango J, Lee EH, Ernst-Russell MA, Takeshima H, Ma J, Allen PD, Pessah IN. Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. J Biol Chem. 2007 Mar 23; 282(12):8667-77.
    View in: PubMed
  24. Yang T, Esteve E, Pessah IN, Molinski TF, Allen PD, López JR. Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR. Am J Physiol Cell Physiol. 2007 May; 292(5):C1591-8.
    View in: PubMed
  25. Sheridan DC, Takekura H, Franzini-Armstrong C, Beam KG, Allen PD, Perez CF. Bidirectional signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19760-5.
    View in: PubMed
  26. Yang T, Riehl J, Esteve E, Matthaei KI, Goth S, Allen PD, Pessah IN, Lopez JR. Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology. 2006 Dec; 105(6):1164-75.
    View in: PubMed
  27. Lee EH, Song DW, Lee JM, Meissner G, Allen PD, Kim do H. Occurrence of atypical Ca2+ transients in triadin-binding deficient-RYR1 mutants. Biochem Biophys Res Commun. 2006 Dec 29; 351(4):909-14.
    View in: PubMed
  28. Moussa CE, Fu Q, Kumar P, Shtifman A, Lopez JR, Allen PD, LaFerla F, Weinberg D, Magrane J, Aprahamian T, Walsh K, Rosen KM, Querfurth HW. Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology. FASEB J. 2006 Oct; 20(12):2165-7.
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  29. Lee EH, Kim do H, Allen PD. Interplay between intra- and extracellular calcium ions. Mol Cells. 2006 Jun 30; 21(3):315-29.
    View in: PubMed
  30. Fessenden JD, Feng W, Pessah IN, Allen PD. Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol. J Biol Chem. 2006 Jul 28; 281(30):21022-31.
    View in: PubMed
  31. Jacobson AR, Moe ST, Allen PD, Fessenden JD. Structural determinants of 4-chloro-m-cresol required for activation of ryanodine receptor type 1. Mol Pharmacol. 2006 Jul; 70(1):259-66.
    View in: PubMed
  32. Lee EH, Cherednichenko G, Pessah IN, Allen PD. Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins. J Biol Chem. 2006 Apr 14; 281(15):10042-8.
    View in: PubMed
  33. Samsó M, Shen X, Allen PD. Structural characterization of the RyR1-FKBP12 interaction. J Mol Biol. 2006 Mar 3; 356(4):917-27.
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  34. Hurne AM, O'Brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG, Pessah IN. Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion. J Biol Chem. 2005 Nov 4; 280(44):36994-7004.
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  35. Cunha-Neto E, Dzau VJ, Allen PD, Stamatiou D, Benvenutti L, Higuchi ML, Koyama NS, Silva JS, Kalil J, Liew CC. Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. Am J Pathol. 2005 Aug; 167(2):305-13.
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  36. Samsó M, Wagenknecht T, Allen PD. Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM. Nat Struct Mol Biol. 2005 Jun; 12(6):539-44.
    View in: PubMed
  37. López JR, Mijares A, Rojas B, Linares N, Allen PD, Shtifman A. Altered Ca2+ homeostasis in human uremic skeletal muscle: possible involvement of cADPR in elevation of intracellular resting [Ca2+]. Nephron Physiol. 2005; 100(4):p51-60.
    View in: PubMed
  38. Allen PD. Anesthesia and the human genome project: the quest for accurate prediction of drug responses. Anesthesiology. 2005 Mar; 102(3):494-5.
    View in: PubMed
  39. Perez CF, López JR, Allen PD. Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle. Am J Physiol Cell Physiol. 2005 Mar; 288(3):C640-9.
    View in: PubMed
  40. López JR, Linares N, Pessah IN, Allen PD. Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i. Am J Physiol Cell Physiol. 2005 Mar; 288(3):C606-12.
    View in: PubMed
  41. Cherednichenko G, Hurne AM, Fessenden JD, Lee EH, Allen PD, Beam KG, Pessah IN. Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proc Natl Acad Sci U S A. 2004 Nov 2; 101(44):15793-8.
    View in: PubMed
  42. Fessenden JD, Feng W, Pessah IN, Allen PD. Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1. J Biol Chem. 2004 Dec 17; 279(51):53028-35.
    View in: PubMed
  43. Christensen RA, Shtifman A, Allen PD, Lopez JR, Querfurth HW. Calcium dyshomeostasis in beta-amyloid and tau-bearing skeletal myotubes. J Biol Chem. 2004 Dec 17; 279(51):53524-32.
    View in: PubMed
  44. Weiss RG, O'Connell KM, Flucher BE, Allen PD, Grabner M, Dirksen RT. Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C1094-102.
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  45. Rivier F, Alkan O, Flint AF, Muskiewicz K, Allen PD, Leboulch P, Gussoni E. Role of bone marrow cell trafficking in replenishing skeletal muscle SP and MP cell populations. J Cell Sci. 2004 Apr 15; 117(Pt 10):1979-88.
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  46. Lee EH, Rho SH, Kwon SJ, Eom SH, Allen PD, Kim do H. N-terminal region of FKBP12 is essential for binding to the skeletal ryanodine receptor. J Biol Chem. 2004 Jun 18; 279(25):26481-8.
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  47. Zhu X, Ghanta J, Walker JW, Allen PD, Valdivia HH. The calmodulin binding region of the skeletal ryanodine receptor acts as a self-modulatory domain. Cell Calcium. 2004 Feb; 35(2):165-77.
    View in: PubMed
  48. Protasi F, Shtifman A, Julian FJ, Allen PD. All three ryanodine receptor isoforms generate rapid cooling responses in muscle cells. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C662-70.
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  49. Allen PD. Not all sudden death is the same. Circ Res. 2003 Sep 19; 93(6):484-6.
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  50. Lee EH, Lopez JR, Li J, Protasi F, Pessah IN, Kim DH, Allen PD. Conformational coupling of DHPR and RyR1 in skeletal myotubes is influenced by long-range allosterism: evidence for a negative regulatory module. Am J Physiol Cell Physiol. 2004 Jan; 286(1):C179-89.
    View in: PubMed
  51. Shtifman A, Paolini C, López JR, Allen PD, Protasi F. Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle. Am J Physiol Cell Physiol. 2004 Jan; 286(1):C73-8.
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  52. Bakowska JC, Di Maria MV, Camp SM, Wang Y, Allen PD, Breakefield XO. Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep(+) hybrid amplicon vector. Gene Ther. 2003 Sep; 10(19):1691-702.
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  53. Perez CF, Mukherjee S, Allen PD. Amino acids 1-1,680 of ryanodine receptor type 1 hold critical determinants of skeletal type for excitation-contraction coupling. Role of divergence domain D2. J Biol Chem. 2003 Oct 10; 278(41):39644-52.
    View in: PubMed
  54. Fessenden JD, Perez CF, Goth S, Pessah IN, Allen PD. Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol. J Biol Chem. 2003 Aug 1; 278(31):28727-35.
    View in: PubMed
  55. Yang T, Ta TA, Pessah IN, Allen PD. Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling. J Biol Chem. 2003 Jul 11; 278(28):25722-30.
    View in: PubMed
  56. Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT. FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem. 2003 Jun 20; 278(25):22600-8.
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  57. Perez CF, Voss A, Pessah IN, Allen PD. RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C coupling. Biophys J. 2003 Apr; 84(4):2655-63.
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  58. Chen L, Estève E, Sabatier JM, Ronjat M, De Waard M, Allen PD, Pessah IN. Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism. J Biol Chem. 2003 May 2; 278(18):16095-106.
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  59. Dos Remedios CG, Liew CC, Allen PD, Winslow RL, Van Eyk JE, Dunn MJ. Genomics, proteomics and bioinformatics of human heart failure. J Muscle Res Cell Motil. 2003; 24(4-6):251-60.
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  60. Lam P, Hui KM, Wang Y, Allen PD, Louis DN, Yuan CJ, Breakefield XO. Dynamics of transgene expression in human glioblastoma cells mediated by herpes simplex virus/adeno-associated virus amplicon vectors. Hum Gene Ther. 2002 Dec 10; 13(18):2147-59.
    View in: PubMed
  61. Protasi F, Paolini C, Nakai J, Beam KG, Franzini-Armstrong C, Allen PD. Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle. Biophys J. 2002 Dec; 83(6):3230-44.
    View in: PubMed
  62. Allen PD, López JR. "Noninvasive" testing for malignant hyperthermia susceptibility. Anesthesiology. 2002 Nov; 97(5):1045-6.
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  63. Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN. Homer regulates gain of ryanodine receptor type 1 channel complex. J Biol Chem. 2002 Nov 22; 277(47):44722-30.
    View in: PubMed
  64. Allen PD. Leaky "feet" and sudden death. Circ Res. 2002 Aug 9; 91(3):181-2.
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  65. Hwang JJ, Allen PD, Tseng GC, Lam CW, Fananapazir L, Dzau VJ, Liew CC. Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure. Physiol Genomics. 2002 Jul 12; 10(1):31-44.
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  66. Wang Y, Camp SM, Niwano M, Shen X, Bakowska JC, Breakefield XO, Allen PD. Herpes simplex virus type 1/adeno-associated virus rep(+) hybrid amplicon vector improves the stability of transgene expression in human cells by site-specific integration. J Virol. 2002 Jul; 76(14):7150-62.
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  67. Yang HT, Tweedie D, Wang S, Guia A, Vinogradova T, Bogdanov K, Allen PD, Stern MD, Lakatta EG, Boheler KR. The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development. Proc Natl Acad Sci U S A. 2002 Jul 9; 99(14):9225-30.
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  68. Rossi D, Simeoni I, Micheli M, Bootman M, Lipp P, Allen PD, Sorrentino V. RyR1 and RyR3 isoforms provide distinct intracellular Ca2+ signals in HEK 293 cells. J Cell Sci. 2002 Jun 15; 115(Pt 12):2497-504.
    View in: PubMed
  69. Barrans JD, Allen PD, Stamatiou D, Dzau VJ, Liew CC. Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. Am J Pathol. 2002 Jun; 160(6):2035-43.
    View in: PubMed
  70. Felder E, Protasi F, Hirsch R, Franzini-Armstrong C, Allen PD. Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle. Biophys J. 2002 Jun; 82(6):3144-9.
    View in: PubMed
  71. O'Brien JJ, Feng W, Allen PD, Chen SR, Pessah IN, Beam KG. Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction coupling. Biophys J. 2002 May; 82(5):2428-35.
    View in: PubMed
  72. Wang Y, Mukherjee S, Fraefel C, Breakefield XO, Allen PD. Herpes simplex virus type 1 amplicon vector-mediated gene transfer to muscle. Hum Gene Ther. 2002 Jan 20; 13(2):261-73.
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  73. Bujold M, Caron N, Camiran G, Mukherjee S, Allen PD, Tremblay JP, Wang Y. Autotransplantation in mdx mice of mdx myoblasts genetically corrected by an HSV-1 amplicon vector. Cell Transplant. 2002; 11(8):759-67.
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  74. Ward CW, Protasi F, Castillo D, Wang Y, Chen SR, Pessah IN, Allen PD, Schneider MF. Type 1 and type 3 ryanodine receptors generate different Ca(2+) release event activity in both intact and permeabilized myotubes. Biophys J. 2001 Dec; 81(6):3216-30.
    View in: PubMed
  75. Proenza C, O'Brien J, Nakai J, Mukherjee S, Allen PD, Beam KG. Identification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loop. J Biol Chem. 2002 Feb 22; 277(8):6530-5.
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  76. Estrada M, Cárdenas C, Liberona JL, Carrasco MA, Mignery GA, Allen PD, Jaimovich E. Calcium transients in 1B5 myotubes lacking ryanodine receptors are related to inositol trisphosphate receptors. J Biol Chem. 2001 Jun 22; 276(25):22868-74.
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  77. Bowling N, Huang X, Sandusky GE, Fouts RL, Mintze K, Esterman M, Allen PD, Maddi R, McCall E, Vlahos CJ. Protein kinase C-alpha and -epsilon modulate connexin-43 phosphorylation in human heart. J Mol Cell Cardiol. 2001 Apr; 33(4):789-98.
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  78. Lelievr LG, Crambert G, Allen PD. Expression of functional Na,K-ATPase isozymes in normal human cardiac biopsies. Cell Mol Biol (Noisy-le-grand). 2001 Mar; 47(2):265-71.
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  79. Fessenden JD, Chen L, Wang Y, Paolini C, Franzini-Armstrong C, Allen PD, Pessah IN. Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2865-70.
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  80. Feng W, Liu G, Allen PD, Pessah IN. Transmembrane redox sensor of ryanodine receptor complex. J Biol Chem. 2000 Nov 17; 275(46):35902-7.
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  81. Fessenden JD, Wang Y, Moore RA, Chen SR, Allen PD, Pessah IN. Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell line. Biophys J. 2000 Nov; 79(5):2509-25.
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  82. Protasi F, Takekura H, Wang Y, Chen SR, Meissner G, Allen PD, Franzini-Armstrong C. RYR1 and RYR3 have different roles in the assembly of calcium release units of skeletal muscle. Biophys J. 2000 Nov; 79(5):2494-508.
    View in: PubMed
  83. Kiselyov KI, Shin DM, Wang Y, Pessah IN, Allen PD, Muallem S. Gating of store-operated channels by conformational coupling to ryanodine receptors. Mol Cell. 2000 Aug; 6(2):421-31.
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  84. López JR, Cordovez G, Linares N, Allen PD. Cyclic ADP-ribose induces a larger than normal calcium release in malignant hyperthermia-susceptible skeletal muscle fibers. Pflugers Arch. 2000 Jun; 440(2):236-42.
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  85. López JR, Contreras J, Linares N, Allen PD. Hypersensitivity of malignant hyperthermia-susceptible swine skeletal muscle to caffeine is mediated by high resting myoplasmic [Ca2+ ]. Anesthesiology. 2000 Jun; 92(6):1799-806.
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  86. Ward CW, Schneider MF, Castillo D, Protasi F, Wang Y, Chen SR, Allen PD. Expression of ryanodine receptor RyR3 produces Ca2+ sparks in dyspedic myotubes. J Physiol. 2000 May 15; 525 Pt 1:91-103.
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  87. Fajloun Z, Kharrat R, Chen L, Lecomte C, Di Luccio E, Bichet D, El Ayeb M, Rochat H, Allen PD, Pessah IN, De Waard M, Sabatier JM. Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors. FEBS Lett. 2000 Mar 10; 469(2-3):179-85.
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  88. Wang Y, Fraefel C, Protasi F, Moore RA, Fessenden JD, Pessah IN, DiFrancesco A, Breakefield X, Allen PD. HSV-1 amplicon vectors are a highly efficient gene delivery system for skeletal muscle myoblasts and myotubes. Am J Physiol Cell Physiol. 2000 Mar; 278(3):C619-26.
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  89. Nakai J, Sekiguchi N, Rando TA, Allen PD, Beam KG. Two regions of the ryanodine receptor involved in coupling with L-type Ca2+ channels. J Biol Chem. 1998 May 29; 273(22):13403-6.
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  90. Moore RA, Nguyen H, Galceran J, Pessah IN, Allen PD. A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein and function. J Cell Biol. 1998 Feb 23; 140(4):843-51.
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  91. Protasi F, Franzini-Armstrong C, Allen PD. Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle. J Cell Biol. 1998 Feb 23; 140(4):831-42.
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  92. Barone V, Bertocchini F, Bottinelli R, Protasi F, Allen PD, Franzini Armstrong C, Reggiani C, Sorrentino V. Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors. FEBS Lett. 1998 Jan 30; 422(2):160-4.
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  93. Nakashima Y, Nishimura S, Maeda A, Barsoumian EL, Hakamata Y, Nakai J, Allen PD, Imoto K, Kita T. Molecular cloning and characterization of a human brain ryanodine receptor. FEBS Lett. 1997 Nov 3; 417(1):157-62.
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  94. Mesnard-Rouiller L, Mercadier JJ, Butler-Browne G, Heimburger M, Logeart D, Allen PD, Samson F. Troponin T mRNA and protein isoforms in the human left ventricle: pattern of expression in failing and control hearts. J Mol Cell Cardiol. 1997 Nov; 29(11):3043-55.
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  95. Bodor GS, Oakeley AE, Allen PD, Crimmins DL, Ladenson JH, Anderson PA. Troponin I phosphorylation in the normal and failing adult human heart. Circulation. 1997 Sep 2; 96(5):1495-500.
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  96. Oppenheim RW, Prevette D, Houenou LJ, Pincon-Raymond M, Dimitriadou V, Donevan A, O'Donovan M, Wenner P, Mckemy DD, Allen PD. Neuromuscular development in the avian paralytic mutant crooked neck dwarf (cn/cn): further evidence for the role of neuromuscular activity in motoneuron survival. J Comp Neurol. 1997 May 12; 381(3):353-72.
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  97. Sainte Beuve C, Allen PD, Dambrin G, Rannou F, Marty I, Trouvé P, Bors V, Pavie A, Gandgjbakch I, Charlemagne D. Cardiac calcium release channel (ryanodine receptor) in control and cardiomyopathic human hearts: mRNA and protein contents are differentially regulated. J Mol Cell Cardiol. 1997 Apr; 29(4):1237-46.
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  98. Buck ED, Nguyen HT, Pessah IN, Allen PD. Dyspedic mouse skeletal muscle expresses major elements of the triadic junction but lacks detectable ryanodine receptor protein and function. J Biol Chem. 1997 Mar 14; 272(11):7360-7.
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  99. Nakai J, Ogura T, Protasi F, Franzini-Armstrong C, Allen PD, Beam KG. Functional nonequality of the cardiac and skeletal ryanodine receptors. Proc Natl Acad Sci U S A. 1997 Feb 4; 94(3):1019-22.
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  100. Pessah IN, Molinski TF, Meloy TD, Wong P, Buck ED, Allen PD, Mohr FC, Mack MM. Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells. Am J Physiol. 1997 Feb; 272(2 Pt 1):C601-14.
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  101. Hasenfuss G, Mulieri LA, Allen PD, Just H, Alpert NR. Influence of isoproterenol and ouabain on excitation-contraction coupling, cross-bridge function, and energetics in failing human myocardium. Circulation. 1996 Dec 15; 94(12):3155-60.
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  102. Nascimben L, Ingwall JS, Pauletto P, Friedrich J, Gwathmey JK, Saks V, Pessina AC, Allen PD. Creatine kinase system in failing and nonfailing human myocardium. Circulation. 1996 Oct 15; 94(8):1894-901.
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  103. Tunwell RE, Wickenden C, Bertrand BM, Shevchenko VI, Walsh MB, Allen PD, Lai FA. The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis. Biochem J. 1996 Sep 1; 318 ( Pt 2):477-87.
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  104. Nakai J, Dirksen RT, Nguyen HT, Pessah IN, Beam KG, Allen PD. Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor. Nature. 1996 Mar 7; 380(6569):72-5.
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  105. Hübner N, Kreutz R, Rubattu S, Lee YA, Ganten D, Allen PD, Lindpaintner K. The gene encoding endothelial nitric oxide synthase, Nos3, maps to rat chromosome 4. Mamm Genome. 1995 Oct; 6(10):758-9.
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  106. Hamman BL, Bittl JA, Jacobus WE, Allen PD, Spencer RS, Tian R, Ingwall JS. Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts. Am J Physiol. 1995 Sep; 269(3 Pt 2):H1030-6.
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  107. Anderson PA, Greig A, Mark TM, Malouf NN, Oakeley AE, Ungerleider RM, Allen PD, Kay BK. Molecular basis of human cardiac troponin T isoforms expressed in the developing, adult, and failing heart. Circ Res. 1995 Apr; 76(4):681-6.
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  108. Ryan JF, Lopez JR, Sanchez VB, Sréter FA, Allen PD. Myoplasmic calcium changes precede metabolic and clinical signs of porcine malignant hyperthermia. Anesth Analg. 1994 Nov; 79(5):1007-11.
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  109. Glass MG, Fuleihan F, Liao R, Lincoff AM, Chapados R, Hamlin R, Apstein CS, Allen PD, Ingwall JS, Hajjar RJ, et al. Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force. Circ Res. 1993 Dec; 73(6):1077-89.
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  110. Perreault CL, Hague NL, Morgan KG, Allen PD, Morgan JP. Negative inotropic and relaxant effects of cocaine on myopathic human ventricular myocardium and epicardial coronary arteries in vitro. Cardiovasc Res. 1993 Feb; 27(2):262-8.
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  111. Schmidt TA, Allen PD, Colucci WS, Marsh JD, Kjeldsen K. No adaptation to digitalization as evaluated by digitalis receptor (Na,K-ATPase) quantification in explanted hearts from donors without heart disease and from digitalized recipients with end-stage heart failure. Am J Cardiol. 1993 Jan 1; 71(1):110-4.
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  112. Takahashi T, Allen PD, Lacro RV, Marks AR, Dennis AR, Schoen FJ, Grossman W, Marsh JD, Izumo S. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J Clin Invest. 1992 Sep; 90(3):927-35.
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  113. Perreault CL, Mulieri LA, Alpert NR, Ransil BJ, Allen PD, Morgan JP. Cellular basis of negative inotropic effect of 2,3-butanedione monoxime in human myocardium. Am J Physiol. 1992 Aug; 263(2 Pt 2):H503-10.
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  114. Takahashi T, Allen PD, Izumo S. Expression of A-, B-, and C-type natriuretic peptide genes in failing and developing human ventricles. Correlation with expression of the Ca(2+)-ATPase gene. Circ Res. 1992 Jul; 71(1):9-17.
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  115. Hasenfuss G, Mulieri LA, Leavitt BJ, Allen PD, Haeberle JR, Alpert NR. Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy. Circ Res. 1992 Jun; 70(6):1225-32.
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  116. Lopez JR, Gerardi A, Lopez MJ, Allen PD. Effects of dantrolene on myoplasmic free [Ca2+] measured in vivo in patients susceptible to malignant hyperthermia. Anesthesiology. 1992 May; 76(5):711-9.
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  117. Mulieri LA, Hasenfuss G, Leavitt B, Allen PD, Alpert NR. Altered myocardial force-frequency relation in human heart failure. Circulation. 1992 May; 85(5):1743-50.
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  118. Hasenfuss G, Mulieri LA, Leavitt BJ, Allen PD, Holubarsch C, Just H, Alpert NR. Contractile protein function in failing and nonfailing human myocardium. Basic Res Cardiol. 1992; 87 Suppl 1:107-16.
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  119. Allen PD, Schmidt TA, Marsh JD, Kjeldsen K. Na,K-ATPase expression in normal and failing human left ventricle. Basic Res Cardiol. 1992; 87 Suppl 1:87-94.
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  120. Anderson PA, Malouf NN, Oakeley AE, Pagani ED, Allen PD. Troponin T isoform expression in the normal and failing human left ventricle: a correlation with myofibrillar ATPase activity. Basic Res Cardiol. 1992; 87 Suppl 1:117-27.
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  121. Mulieri LA, Leavitt BJ, Hasenfuss G, Allen PD, Alpert NR. Contraction frequency dependence of twitch and diastolic tension in human dilated cardiomyopathy (tension-frequency relation in cardiomyopathy). Basic Res Cardiol. 1992; 87 Suppl 1:199-212.
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  122. Allen PD, López JR, Sánchez V, Ryan JF, Sreter FA. EU 4093 decreases intracellular [Ca2+] in skeletal muscle fibers from control and malignant hyperthermia-susceptible swine. Anesthesiology. 1992 Jan; 76(1):132-8.
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  123. Anderson PA, Malouf NN, Oakeley AE, Pagani ED, Allen PD. Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle. Circ Res. 1991 Nov; 69(5):1226-33.
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  124. Medford RM, Hyman R, Ahmad M, Allen JC, Pressley TA, Allen PD, Nadal-Ginard B. Vascular smooth muscle expresses a truncated Na+, K(+)-ATPase alpha-1 subunit isoform. J Biol Chem. 1991 Sep 25; 266(27):18308-12.
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  125. Boheler KR, Carrier L, de la Bastie D, Allen PD, Komajda M, Mercadier JJ, Schwartz K. Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts. J Clin Invest. 1991 Jul; 88(1):323-30.
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  126. Ikeda U, Briggs GM, Allen PD, Sen L, Medford RM, Smith TW. Properties of adult rat ventricular cells in long-term culture. Cardioscience. 1990 Sep; 1(3):225-33.
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  127. Lopez JR, Sanchez V, Lopez I, Ryan JF, Mendoza M, Sreter FA, Allen PD. The effects of extracellular magnesium on myoplasmic [Ca2+] in malignant hyperthermia susceptible swine. Anesthesiology. 1990 Jul; 73(1):109-17.
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  128. Morgan JP, Erny RE, Allen PD, Grossman W, Gwathmey JK. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation. 1990 Feb; 81(2 Suppl):III21-32.
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  129. Mercadier JJ, Lompré AM, Duc P, Boheler KR, Fraysse JB, Wisnewsky C, Allen PD, Komajda M, Schwartz K. Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure. J Clin Invest. 1990 Jan; 85(1):305-9.
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  130. Denniss AR, Colucci WS, Allen PD, Marsh JD. Distribution and function of human ventricular beta adrenergic receptors in congestive heart failure. J Mol Cell Cardiol. 1989 Jul; 21(7):651-60.
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  131. Lema MJ, Pluskal MG, Allen PD. High-performance ion-exchange chromatography of myosin using a DEAE-5PW column. J Chromatogr. 1989 Jun 30; 491(1):61-8.
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  132. Desai SP, Marsh JD, Allen PD. Contractility effects of local anesthetics in the presence of sodium channel blockade. Reg Anesth. 1989 Mar-Apr; 14(2):58-62.
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  133. Marsh JD, Allen PD. Developmental regulation of cardiac calcium channels and contractile sensitivity to [Ca]o. Am J Physiol. 1989 Jan; 256(1 Pt 2):H179-85.
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  134. MacKinnon R, Gwathmey JK, Allen PD, Briggs GM, Morgan JP. Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle. Circ Res. 1988 Dec; 63(6):1080-9.
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  135. Pagani ED, Alousi AA, Grant AM, Older TM, Dziuban SW, Allen PD. Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency. Circ Res. 1988 Aug; 63(2):380-5.
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  136. Alousi AA, Grant AM, Allen PD, Pagani ED. Effects of milrinone on Ca++-sensitivity of myofibrillar Mg-adenosine triphosphatase isolated from normal human and canine hearts. J Pharmacol Exp Ther. 1988 Jul; 246(1):30-7.
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  137. Stomper PC, Kopans DB, Sadowsky NL, Sonnenfeld MR, Swann CA, Gelman RS, Meyer JE, Jochelson MS, Hunt MS, Allen PD. Is mammography painful? A multicenter patient survey. Arch Intern Med. 1988 Mar; 148(3):521-4.
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  138. López JR, Allen PD, Alamo L, Jones D, Sreter FA. Myoplasmic free [Ca2+] during a malignant hyperthermia episode in swine. Muscle Nerve. 1988 Jan; 11(1):82-8.
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  139. Brooks WW, Bing OH, Blaustein AS, Allen PD. Comparison of contractile state and myosin isozymes of rat right and left ventricular myocardium. J Mol Cell Cardiol. 1987 May; 19(5):433-40.
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  140. Allen PD, Ryan JF, Jones DE, Mabuchi K, Virga A, Roberts J, Sreter F. Sarcoplasmic reticulum calcium uptake in cryostat sections of skeletal muscle from malignant hyperthermia patients and controls. Muscle Nerve. 1986 Jun; 9(5):474-5.
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  141. Allen PD, Walman T, Concepcion M, Sheskey M, Patterson MK, Cullen D, Covino BG. Epidural morphine provides postoperative pain relief in peripheral vascular and orthopedic surgical patients: a dose-response study. Anesth Analg. 1986 Feb; 65(2):165-70.
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  142. Lopez JR, Alamo LA, Jones DE, Papp L, Allen PD, Gergely J, Sréter FA. [Ca2+]i in muscles of malignant hyperthermia susceptible pigs determined in vivo with Ca2+ selective microelectrodes. Muscle Nerve. 1986 Jan; 9(1):85-6.
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  143. Ingwall JS, Kramer MF, Fifer MA, Lorell BH, Shemin R, Grossman W, Allen PD. The creatine kinase system in normal and diseased human myocardium. N Engl J Med. 1985 Oct 24; 313(17):1050-4.
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  144. Pike MM, Frazer JC, Dedrick DF, Ingwall JS, Allen PD, Springer CS, Smith TW. 23Na and 39K nuclear magnetic resonance studies of perfused rat hearts. Discrimination of intra- and extracellular ions using a shift reagent. Biophys J. 1985 Jul; 48(1):159-73.
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  145. Bourke DL, Rosenberg M, Allen PD. Physostigmine: effectiveness as an antagonist of respiratory depression and psychomotor effects caused by morphine or diazepam. Anesthesiology. 1984 Nov; 61(5):523-8.
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  146. Kim DH, Sreter FA, Ohnishi ST, Ryan JF, Roberts J, Allen PD, Meszaros LG, Antoniu B, Ikemoto N. Kinetic studies of Ca2+ release from sarcoplasmic reticulum of normal and malignant hyperthermia susceptible pig muscles. Biochim Biophys Acta. 1984 Sep 5; 775(3):320-7.
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  147. Huval WV, Lelcuk S, Allen PD, Mannick JA, Shepro D, Hechtman HB. Determinants of cardiovascular stability during abdominal aortic aneurysmectomy (AAA). Ann Surg. 1984 Feb; 199(2):216-22.
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  148. Krausz MM, Utsunomiya T, McIrvine AJ, Allen PD, Levine L, Mannick JA, Shepro D, Hechtman HB. Modulation of cardiovascular function and platelet survival by endogenous prostacyclin released during surgery. Surgery. 1983 Apr; 93(4):554-9.
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  149. Bourke DL, Allen PD, Rosenberg M, Mendes RW, Karabelas AN. Dextroamphetamine with morphine: respiratory effects. J Clin Pharmacol. 1983 Jan; 23(1):65-70.
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  150. Utsunomiya T, Krausz MM, Dunham B, Mannick JA, Allen PD, Shepro D, Hechtman HB. Maintenance of cardiodynamics with aspirin during abdominal aortic aneurysmectomy (AAA). Ann Surg. 1981 Nov; 194(5):602-8.
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  151. Allen PD, Pandolf KB. Perceived exertion associated with breathing hyperoxic mixtures during submaximal work. Med Sci Sports. 1977; 9(2):122-7.
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  152. Barclay JK, Allen PD, Stainsby WN. The relationship between temperature and oxygen uptake of contracting skeletal muscle. Med Sci Sports. 1974; 6(1):33-7.
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  153. Jacobsen DC, Soden KJ, Allen PD, Daicoff GR. Humoral blockade on lethal pulmonary embolism in the awake dog. Surg Forum. 1971; 22:209-11.
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  154. ABEL WG, ALLEN PD. Acute appendicitis in children; a review of 1,165 cases. Ann Surg. 1950 Dec; 132(6):1093-1102.
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