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Last Name
Institution

Gary Steven Sachs, M.D.

TitleAssociate Clinical Professor of Psychiatry
InstitutionMassachusetts General Hospital
DepartmentPsychiatry
AddressMassachusetts General Hospital
Wac 812
15 Parkman Street
Boston MA 02114
Phone617/726-6188
Fax617/726-6768

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ghaemi SN, Ostacher MM, El-Mallakh RS, Borrelli D, Baldassano CF, Kelley ME, Filkowski MM, Hennen J, Sachs GS, Goodwin FK, Baldessarini RJ. Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety. J Clin Psychiatry. 2010 Apr; 71(4):372-80.
    View in: PubMed
  2. Perlis RH, Ostacher MJ, Miklowitz DJ, Hay A, Nierenberg AA, Thase ME, Sachs GS. Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. J Clin Psychiatry. 2010 Mar; 71(3):296-303.
    View in: PubMed
  3. Perlis RH, Ostacher M, Fava M, Nierenberg AA, Sachs GS, Rosenbaum JF. Assuring that double-blind is blind. Am J Psychiatry. 2010 Mar; 167(3):250-2.
    View in: PubMed
  4. Perlis RH, Ostacher MJ, Miklowitz DJ, Smoller JW, Dennehy EB, Cowperthwait C, Nierenberg AA, Thase ME, Sachs GS. Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report. J Clin Psychiatry. 2010 Feb; 71(2):194-200.
    View in: PubMed
  5. Casamassima F, Huang J, Fava M, Sachs GS, Smoller JW, Cassano GB, Lattanzi L, Fagerness J, Stange JP, Perlis RH. Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5; 153B(1):303-9.
    View in: PubMed
  6. Fan J, Ionita-Laza I, McQueen MB, Devlin B, Purcell S, Faraone SV, Allen MH, Bowden CL, Calabrese JR, Fossey MD, Friedman ES, Gyulai L, Hauser P, Ketter TB, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel JK, Sachs GS, Thase ME, Molay FB, Escamilla MA, Nimgaonkar VL, Sklar P, Laird NM, Smoller JW. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5; 153B(1):29-37.
    View in: PubMed
  7. Ostacher MJ, Perlis RH, Nierenberg AA, Calabrese J, Stange JP, Salloum I, Weiss RD, Sachs GS. Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry. 2010 Mar; 167(3):289-97.
    View in: PubMed
  8. Kane JM, Barnes TR, Correll CU, Sachs G, Buckley P, Eudicone J, McQuade R, Tran QV, Pikalov A, Assunção-Talbott S. Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials. J Psychopharmacol. 2010 Jul; 24(7):1019-29.
    View in: PubMed
  9. Perlis RH, Ostacher MJ, Uher R, Nierenberg AA, Casamassima F, Kansky C, Calabrese JR, Thase M, Sachs GS. Stability of symptoms across major depressive episodes in bipolar disorder. Bipolar Disord. 2009 Dec; 11(8):867-75.
    View in: PubMed
  10. Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, Bowden CL, Calabrese J, El-Mallakh RS, Escamilla M, Faraone SV, Fossey MD, Gyulai L, Loftis JM, Hauser P, Ketter TA, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Laird N, Keshavan M, Thase ME, Axelson D, Birmaher B, Lewis D, Monk T, Frank E, Kupfer DJ, Devlin B, Nimgaonkar VL. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009 Nov; 11(7):701-10.
    View in: PubMed
  11. Ostacher MJ, Lebeau RT, Perlis RH, Nierenberg AA, Lund HG, Moshier SJ, Sachs GS, Simon NM. Cigarette smoking is associated with suicidality in bipolar disorder. Bipolar Disord. 2009 Nov; 11(7):766-71.
    View in: PubMed
  12. Ng F, Mammen OK, Wilting I, Sachs GS, Ferrier IN, Cassidy F, Beaulieu S, Yatham LN, Berk M. The International Society for Bipolar Disorders (ISBD) consensus guidelines for the safety monitoring of bipolar disorder treatments. Bipolar Disord. 2009 Sep; 11(6):559-95.
    View in: PubMed
  13. Tohen M, Frank E, Bowden CL, Colom F, Ghaemi SN, Yatham LN, Malhi GS, Calabrese JR, Nolen WA, Vieta E, Kapczinski F, Goodwin GM, Suppes T, Sachs GS, Chengappa KR, Grunze H, Mitchell PB, Kanba S, Berk M. The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders. Bipolar Disord. 2009 Aug; 11(5):453-73.
    View in: PubMed
  14. Kogan JN, Bauer MS, Dennehy EB, Miklowitz DJ, Gonzalez JM, Thompson PM, Sachs GS. Increasing minority research participation through collaboration with community outpatient clinics: the STEP-BD Community Partners Experience. Clin Trials. 2009 Aug; 6(4):344-54.
    View in: PubMed
  15. Perlis RH, Dennehy EB, Miklowitz DJ, Delbello MP, Ostacher M, Calabrese JR, Ametrano RM, Wisniewski SR, Bowden CL, Thase ME, Nierenberg AA, Sachs G. Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study. Bipolar Disord. 2009 Jun; 11(4):391-400.
    View in: PubMed
  16. Perlis RH, Smoller JW, Ferreira MA, McQuillin A, Bass N, Lawrence J, Sachs GS, Nimgaonkar V, Scolnick EM, Gurling H, Sklar P, Purcell S. A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder. Am J Psychiatry. 2009 Jun; 166(6):718-25.
    View in: PubMed
  17. Goldberg JF, Brooks JO, Kurita K, Hoblyn JC, Ghaemi SN, Perlis RH, Miklowitz DJ, Ketter TA, Sachs GS, Thase ME. Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD. J Clin Psychiatry. 2009 Feb; 70(2):155-62.
    View in: PubMed
  18. Kaufman RE, Ostacher MJ, Marks EH, Simon NM, Sachs GS, Jensen JE, Renshaw PF, Pollack MH. Brain GABA levels in patients with bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30; 33(3):427-34.
    View in: PubMed
  19. Goldberg JF, Perlis RH, Bowden CL, Thase ME, Miklowitz DJ, Marangell LB, Calabrese JR, Nierenberg AA, Sachs GS. Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry. 2009 Feb; 166(2):173-81.
    View in: PubMed
  20. Busch AB, Frank RG, Sachs G, Normand SL. Bipolar-I patient characteristics associated with differences in antimanic medication prescribing. Psychopharmacol Bull. 2009; 42(1):35-49.
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  21. Iosifescu DV, Moore CM, Deckersbach T, Tilley CA, Ostacher MJ, Sachs GS, Nierenberg AA. Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of-concept study. CNS Neurosci Ther. 2009; 15(4):309-19.
    View in: PubMed
  22. Tohen M, Sutton VK, Calabrese JR, Sachs GS, Bowden CL. Maintenance of response following stabilization of mixed index episodes with olanzapine monotherapy in a randomized, double-blind, placebo-controlled study of bipolar 1 disorder. J Affect Disord. 2009 Jul; 116(1-2):43-50.
    View in: PubMed
  23. Deckersbach T, Rauch SL, Buhlmann U, Ostacher MJ, Beucke JC, Nierenberg AA, Sachs G, Dougherty DD. An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief report. Bipolar Disord. 2008 Dec; 10(8):928-42.
    View in: PubMed
  24. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008 Sep; 40(9):1056-8.
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  25. Gruber J, Harvey AG, Wang PW, Brooks JO, Thase ME, Sachs GS, Ketter TA. Sleep functioning in relation to mood, function, and quality of life at entry to the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Affect Disord. 2009 Apr; 114(1-3):41-9.
    View in: PubMed
  26. Ostacher MJ, Nierenberg AA, Iosifescu DV, Eidelman P, Lund HG, Ametrano RM, Kaczynski R, Calabrese J, Miklowitz DJ, Sachs GS, Perlick DA. Correlates of subjective and objective burden among caregivers of patients with bipolar disorder. Acta Psychiatr Scand. 2008 Jul; 118(1):49-56.
    View in: PubMed
  27. El-Mallakh RS, Ghaemi SN, Sagduyu K, Thase ME, Wisniewski SR, Nierenberg AA, Zhang HW, Pardo TA, Sachs G. Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patients. J Affect Disord. 2008 Dec; 111(2-3):372-7.
    View in: PubMed
  28. Perlick DA, Rosenheck RA, Miklowitz DJ, Kaczynski R, Link B, Ketter T, Wisniewski S, Wolff N, Sachs G. Caregiver burden and health in bipolar disorder: a cluster analytic approach. J Nerv Ment Dis. 2008 Jun; 196(6):484-91.
    View in: PubMed
  29. Sachs GS. Psychosocial interventions as adjunctive therapy for bipolar disorder. J Psychiatr Pract. 2008 May; 14 Suppl 2:39-44.
    View in: PubMed
  30. Nowakowska C, Sachs GS, Zarate CA, Marangell LB, Calabrese JR, Goldberg JF, Ketter TA. Increased rate of non-right-handedness in patients with bipolar disorder. J Clin Psychiatry. 2008 May; 69(5):866-7.
    View in: PubMed
  31. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM. Whole-genome association study of bipolar disorder. Mol Psychiatry. 2008 Jun; 13(6):558-69.
    View in: PubMed
  32. Schneck CD, Miklowitz DJ, Miyahara S, Araga M, Wisniewski S, Gyulai L, Allen MH, Thase ME, Sachs GS. The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD. Am J Psychiatry. 2008 Mar; 165(3):370-7; quiz 410.
    View in: PubMed
  33. Gyulai L, Bauer MS, Marangell LB, Dennehy EB, Thase ME, Otto MW, Zhang H, Wisniewski SR, Miklowitz DJ, Rapaport MH, Baldassano CF, Sachs GS. Correlates of functioning in bipolar disorder. Psychopharmacol Bull. 2008; 41(4):51-64.
    View in: PubMed
  34. Busch AB, Frank RG, Sachs G. Bipolar-I depression outpatient treatment quality and costs in usual care practice. Psychopharmacol Bull. 2008; 41(2):24-39.
    View in: PubMed
  35. Truman CJ, Goldberg JF, Ghaemi SN, Baldassano CF, Wisniewski SR, Dennehy EB, Thase ME, Sachs GS. Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Clin Psychiatry. 2007 Oct; 68(10):1472-9.
    View in: PubMed
  36. Sachs GS, Gaulin BD, Gutierrez-Esteinou R, McQuade RD, Pikalov A, Pultz JA, Sanchez R, Marcus RN, Crandall DT. Antimanic response to aripiprazole in bipolar I disorder patients is independent of the agitation level at baseline. J Clin Psychiatry. 2007 Sep; 68(9):1377-83.
    View in: PubMed
  37. Reilly-Harrington NA, Deckersbach T, Knauz R, Wu Y, Tran T, Eidelman P, Lund HG, Sachs G, Nierenberg AA. Cognitive behavioral therapy for rapid-cycling bipolar disorder: a pilot study. J Psychiatr Pract. 2007 Sep; 13(5):291-7.
    View in: PubMed
  38. Goldberg JF, Perlis RH, Ghaemi SN, Calabrese JR, Bowden CL, Wisniewski S, Miklowitz DJ, Sachs GS, Thase ME. Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD. Am J Psychiatry. 2007 Sep; 164(9):1348-55.
    View in: PubMed
  39. Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Kogan JN, Sachs GS, Thase ME, Calabrese JR, Marangell LB, Ostacher MJ, Patel J, Thomas MR, Araga M, Gonzalez JM, Wisniewski SR. Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial. Am J Psychiatry. 2007 Sep; 164(9):1340-7.
    View in: PubMed
  40. Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Wisniewski SR, Kogan JN, Nierenberg AA, Calabrese JR, Marangell LB, Gyulai L, Araga M, Gonzalez JM, Shirley ER, Thase ME, Sachs GS. Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program. Arch Gen Psychiatry. 2007 Apr; 64(4):419-26.
    View in: PubMed
  41. Sachs GS, Nierenberg AA, Calabrese JR, Marangell LB, Wisniewski SR, Gyulai L, Friedman ES, Bowden CL, Fossey MD, Ostacher MJ, Ketter TA, Patel J, Hauser P, Rapport D, Martinez JM, Allen MH, Miklowitz DJ, Otto MW, Dennehy EB, Thase ME. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med. 2007 Apr 26; 356(17):1711-22.
    View in: PubMed
  42. Dennehy EB, Bauer MS, Perlis RH, Kogan JN, Sachs GS. Concordance with treatment guidelines for bipolar disorder: data from the systematic treatment enhancement program for bipolar disorder. Psychopharmacol Bull. 2007; 40(3):72-84.
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  43. Sachs GS, Gardner-Schuster EE. Adjunctive treatment of acute mania: a clinical overview. Acta Psychiatr Scand Suppl. 2007; (434):27-34.
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  44. Hofer A, Rettenbacher MA, Edlinger M, Huber R, Bodner T, Kemmler G, Sachs G, Fleischhacker WW. Outcomes in schizophrenia outpatients treated with amisulpride or olanzapine. Pharmacopsychiatry. 2007 Jan; 40(1):1-8.
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  45. Hirschfeld RM, Calabrese JR, Frye MA, Lavori PW, Sachs G, Thase ME, Wagner KD. Defining the clinical course of bipolar disorder: response, remission, relapse, recurrence, and roughening. Psychopharmacol Bull. 2007; 40(3):7-14.
    View in: PubMed
  46. Ostacher MJ, Nierenberg AA, Perlis RH, Eidelman P, Borrelli DJ, Tran TB, Marzilli Ericson G, Weiss RD, Sachs GS. The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorder. J Clin Psychiatry. 2006 Dec; 67(12):1907-11.
    View in: PubMed
  47. Tohen M, Bowden CL, Calabrese JR, Lin D, Forrester TD, Sachs GS, Koukopoulos A, Yatham L, Grunze H. Influence of sub-syndromal symptoms after remission from manic or mixed episodes. Br J Psychiatry. 2006 Dec; 189:515-9.
    View in: PubMed
  48. Henin A, Biederman J, Mick E, Hirshfeld-Becker DR, Sachs GS, Wu Y, Yan L, Ogutha J, Nierenberg AA. Childhood antecedent disorders to bipolar disorder in adults: a controlled study. J Affect Disord. 2007 Apr; 99(1-3):51-7.
    View in: PubMed
  49. Marangell LB, Bauer MS, Dennehy EB, Wisniewski SR, Allen MH, Miklowitz DJ, Oquendo MA, Frank E, Perlis RH, Martinez JM, Fagiolini A, Otto MW, Chessick CA, Zboyan HA, Miyahara S, Sachs G, Thase ME. Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years. Bipolar Disord. 2006 Oct; 8(5 Pt 2):566-75.
    View in: PubMed
  50. Ostacher MJ, Sachs GS. Update on bipolar disorder and substance abuse: recent findings and treatment strategies. J Clin Psychiatry. 2006 Sep; 67(9):e10.
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  51. Joffe H, Cohen LS, Suppes T, Hwang CH, Molay F, Adams JM, Sachs GS, Hall JE. Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary report. Biol Psychiatry. 2006 Dec 15; 60(12):1378-81.
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  52. Marangell LB, Suppes T, Ketter TA, Dennehy EB, Zboyan H, Kertz B, Nierenberg A, Calabrese J, Wisniewski SR, Sachs G. Omega-3 fatty acids in bipolar disorder: clinical and research considerations. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov; 75(4-5):315-21.
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  53. Calabrese JR, Muzina DJ, Kemp DE, Sachs GS, Frye MA, Thompson TR, Klingman D, Reed ML, Hirschfeld RM. Predictors of bipolar disorder risk among patients currently treated for major depression. MedGenMed. 2006; 8(3):38.
    View in: PubMed
  54. Otto MW, Simon NM, Wisniewski SR, Miklowitz DJ, Kogan JN, Reilly-Harrington NA, Frank E, Nierenberg AA, Marangell LB, Sagduyu K, Weiss RD, Miyahara S, Thas ME, Sachs GS, Pollack MH. Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. Br J Psychiatry. 2006 Jul; 189:20-5.
    View in: PubMed
  55. Miklowitz DJ, Otto MW, Wisniewski SR, Araga M, Frank E, Reilly-Harrington NA, Lembke A, Sachs GS. Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorder. Psychiatr Serv. 2006 Jul; 57(7):959-65.
    View in: PubMed
  56. Bowden CL, Calabrese JR, Ketter TA, Sachs GS, White RL, Thompson TR. Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. Am J Psychiatry. 2006 Jul; 163(7):1199-201.
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  57. Reilly-Harrington N, Sachs GS. Psychosocial strategies to improve concordance and adherence in bipolar disorder. J Clin Psychiatry. 2006 Jul; 67(7):e04.
    View in: PubMed
  58. Ghaemi SN, Hsu DJ, Thase ME, Wisniewski SR, Nierenberg AA, Miyahara S, Sachs G. Pharmacological Treatment Patterns at Study Entry for the First 500 STEP-BD Participants. Psychiatr Serv. 2006 May; 57(5):660-5.
    View in: PubMed
  59. Zhang H, Wisniewski SR, Bauer MS, Sachs GS, Thase ME. Comparisons of perceived quality of life across clinical states in bipolar disorder: data from the first 2000 Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) participants. Compr Psychiatry. 2006 May-Jun; 47(3):161-8.
    View in: PubMed
  60. Eden Evins A, Demopulos C, Yovel I, Culhane M, Ogutha J, Grandin LD, Nierenberg AA, Sachs GS. Inositol augmentation of lithium or valproate for bipolar depression. Bipolar Disord. 2006 Apr; 8(2):168-74.
    View in: PubMed
  61. Sachs G, Bowden C, Calabrese JR, Ketter T, Thompson T, White R, Bentley B. Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorder. Bipolar Disord. 2006 Apr; 8(2):175-81.
    View in: PubMed
  62. Wang PW, Sachs GS, Zarate CA, Marangell LB, Calabrese JR, Goldberg JF, Sagduyu K, Miyahara S, Ketter TA. Overweight and obesity in bipolar disorders. J Psychiatr Res. 2006 Dec; 40(8):762-4.
    View in: PubMed
  63. Fossey MD, Otto MW, Yates WR, Wisniewski SR, Gyulai L, Allen MH, Miklowitz DJ, Coon KA, Ostacher MJ, Neel JL, Thase ME, Sachs GS, Weiss RD. Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participants. Am J Addict. 2006 Mar-Apr; 15(2):138-43.
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  64. Pollack MH, Simon NM, Fagiolini A, Pitman R, McNally RJ, Nierenberg AA, Miyahara S, Sachs GS, Perlman C, Ghaemi SN, Thase ME, Otto MW. Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder. J Clin Psychiatry. 2006 Mar; 67(3):394-9.
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  65. Nierenberg AA, Ostacher MJ, Calabrese JR, Ketter TA, Marangell LB, Miklowitz DJ, Miyahara S, Bauer MS, Thase ME, Wisniewski SR, Sachs GS. Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone. Am J Psychiatry. 2006 Feb; 163(2):210-6.
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  66. Joffe H, Kim DR, Foris JM, Baldassano CF, Gyulai L, Hwang CH, McLaughlin WL, Sachs GS, Thase ME, Harlow BL, Cohen LS. Menstrual dysfunction prior to onset of psychiatric illness is reported more commonly by women with bipolar disorder than by women with unipolar depression and healthy controls. J Clin Psychiatry. 2006 Feb; 67(2):297-304.
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  67. Tohen M, Calabrese JR, Sachs GS, Banov MD, Detke HC, Risser R, Baker RW, Chou JC, Bowden CL. Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine. Am J Psychiatry. 2006 Feb; 163(2):247-56.
    View in: PubMed
  68. Perlis RH, Ostacher MJ, Patel JK, Marangell LB, Zhang H, Wisniewski SR, Ketter TA, Miklowitz DJ, Otto MW, Gyulai L, Reilly-Harrington NA, Nierenberg AA, Sachs GS, Thase ME. Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry. 2006 Feb; 163(2):217-24.
    View in: PubMed
  69. Eden Evins A, Demopulos C, Nierenberg A, Culhane MA, Eisner L, Sachs G. A double-blind, placebo-controlled trial of adjunctive donepezil in treatment-resistant mania. Bipolar Disord. 2006 Feb; 8(1):75-80.
    View in: PubMed
  70. Joffe H, Cohen LS, Suppes T, McLaughlin WL, Lavori P, Adams JM, Hwang CH, Hall JE, Sachs GS. Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder. Biol Psychiatry. 2006 Jun 1; 59(11):1078-86.
    View in: PubMed
  71. Sachs G, Sanchez R, Marcus R, Stock E, McQuade R, Carson W, Abou-Gharbia N, Impellizzeri C, Kaplita S, Rollin L, Iwamoto T. Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3-week placebo-controlled study. J Psychopharmacol. 2006 Jul; 20(4):536-46.
    View in: PubMed
  72. Sachs GS. A review of agitation in mental illness: burden of illness and underlying pathology. J Clin Psychiatry. 2006; 67 Suppl 10:5-12.
    View in: PubMed
  73. Nierenberg AA, Ostacher MJ, Borrelli DJ, Iosifescu DV, Perlis RH, Desrosiers A, Armistead MS, Calkins AW, Sachs GS. The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry. J Clin Psychiatry. 2006; 67 Suppl 11:3-7.
    View in: PubMed
  74. Bauer MS, Wisniewski SR, Marangell LB, Chessick CA, Allen MH, Dennehy EB, Miklowitz DJ, Thase ME, Sachs GS. Are antidepressants associated with new-onset suicidality in bipolar disorder? A prospective study of participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Clin Psychiatry. 2006 Jan; 67(1):48-55.
    View in: PubMed
  75. Bauer MS, Wisniewski SR, Kogan JN, Marangell LB, Thase ME, Sachs G. Brief report: paroxetine in younger and adult individuals at high risk for suicide. Psychopharmacol Bull. 2006; 39(1):31-7.
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  76. Sachs GS. Implementing evidence-based treatment of manic and mixed episodes. J Clin Psychiatry. 2006; 67 Suppl 11:12-7.
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  77. Goldberg JF, Allen MH, Miklowitz DA, Bowden CL, Endick CJ, Chessick CA, Wisniewski SR, Miyahara S, Sagduyu K, Thase ME, Calabrese JR, Sachs GS. Suicidal ideation and pharmacotherapy among STEP-BD patients. Psychiatr Serv. 2005 Dec; 56(12):1534-40.
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  78. Allen MH, Chessick CA, Miklowitz DJ, Goldberg JF, Wisniewski SR, Miyahara S, Calabrese JR, Marangell L, Bauer MS, Thomas MR, Bowden CL, Sachs GS. Contributors to suicidal ideation among bipolar patients with and without a history of suicide attempts. Suicide Life Threat Behav. 2005 Dec; 35(6):671-80.
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  79. Bowden CL, Ketter TA, Sachs GS, Thase ME. Focus on bipolar disorder treatment. J Clin Psychiatry. 2005 Dec; 66(12):1598-609.
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  80. Martinez JM, Marangell LB, Simon NM, Miyahara S, Wisniewski SR, Harrington J, Pollack MH, Sachs GS, Thase ME. Baseline predictors of serious adverse events at one year among patients with bipolar disorder in STEP-BD. Psychiatr Serv. 2005 Dec; 56(12):1541-8.
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  81. Baldassano CF, Marangell LB, Gyulai L, Ghaemi SN, Joffe H, Kim DR, Sagduyu K, Truman CJ, Wisniewski SR, Sachs GS, Cohen LS. Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants. Bipolar Disord. 2005 Oct; 7(5):465-70.
    View in: PubMed
  82. Perlis RH, Delbello MP, Miyahara S, Wisniewski SR, Sachs GS, Nierenberg AA. Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants. Biol Psychiatry. 2005 Oct 1; 58(7):549-53.
    View in: PubMed
  83. Deckersbach T, Dougherty DD, Savage C, McMurrich S, Fischman AJ, Nierenberg A, Sachs G, Rauch SL. Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder. Biol Psychiatry. 2006 Jan 15; 59(2):138-46.
    View in: PubMed
  84. Miklowitz DJ, Wisniewski SR, Miyahara S, Otto MW, Sachs GS. Perceived criticism from family members as a predictor of the one-year course of bipolar disorder. Psychiatry Res. 2005 Sep 15; 136(2-3):101-11.
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  85. Henin A, Biederman J, Mick E, Sachs GS, Hirshfeld-Becker DR, Siegel RS, McMurrich S, Grandin L, Nierenberg AA. Psychopathology in the offspring of parents with bipolar disorder: a controlled study. Biol Psychiatry. 2005 Oct 1; 58(7):554-61.
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  86. Sachs GS. Adding a nurse-based intervention programme to usual care improves manic symptoms in people with bipolar disorder. Evid Based Ment Health. 2005 Aug; 8(3):81.
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  87. Suppes T, Dennehy EB, Hirschfeld RM, Altshuler LL, Bowden CL, Calabrese JR, Crismon ML, Ketter TA, Sachs GS, Swann AC. The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder. J Clin Psychiatry. 2005 Jul; 66(7):870-86.
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  88. Tohen M, Greil W, Calabrese JR, Sachs GS, Yatham LN, Oerlinghausen BM, Koukopoulos A, Cassano GB, Grunze H, Licht RW, Dell'Osso L, Evans AR, Risser R, Baker RW, Crane H, Dossenbach MR, Bowden CL. Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial. Am J Psychiatry. 2005 Jul; 162(7):1281-90.
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  89. Weiss RD, Ostacher MJ, Otto MW, Calabrese JR, Fossey M, Wisniewski SR, Bowden CL, Nierenberg AA, Pollack MH, Salloum IM, Simon NM, Thase ME, Sachs GS. Does recovery from substance use disorder matter in patients with bipolar disorder? J Clin Psychiatry. 2005 Jun; 66(6):730-5; quiz 808-9.
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  90. Nierenberg AA, Miyahara S, Spencer T, Wisniewski SR, Otto MW, Simon N, Pollack MH, Ostacher MJ, Yan L, Siegel R, Sachs GS. Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants. Biol Psychiatry. 2005 Jun 1; 57(11):1467-73.
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  91. Deckersbach T, Savage CR, Dougherty DD, Bohne A, Loh R, Nierenberg A, Sachs G, Rauch SL. Spontaneous and directed application of verbal learning strategies in bipolar disorder and obsessive-compulsive disorder. Bipolar Disord. 2005 Apr; 7(2):166-75.
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  92. Yildiz A, Moore CM, Sachs GS, Demopulos CM, Tunca Z, Erbayraktar Z, Renshaw PF. Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled 31P magnetic resonance spectroscopy study. Psychiatry Res. 2005 Jan 30; 138(1):51-9.
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  93. Mansour HA, Talkowski ME, Wood J, Pless L, Bamne M, Chowdari KV, Allen M, Bowden CL, Calabrese J, El-Mallakh RS, Fagiolini A, Faraone SV, Fossey MD, Friedman ES, Gyulai L, Hauser P, Ketter TA, Loftis JM, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Thase ME, Frank E, Kupfer DJ, Nimgaonkar VL. Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporter. Ann Med. 2005; 37(8):590-602.
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  94. Calabrese JR, Keck PE, Bowden CL, Ketter TA, Sachs G, Findling RL, Sajatovic M. A US perspective of the CANMAT bipolar guidelines. Bipolar Disord. 2005; 7 Suppl 3:70-2.
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  95. Simon NM, Otto MW, Wisniewski SR, Fossey M, Sagduyu K, Frank E, Sachs GS, Nierenberg AA, Thase ME, Pollack MH. Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry. 2004 Dec; 161(12):2222-9.
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  96. Hennen J, Perlis RH, Sachs G, Tohen M, Baldessarini RJ. Weight gain during treatment of bipolar I patients with olanzapine. J Clin Psychiatry. 2004 Dec; 65(12):1679-87.
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  97. Kogan JN, Otto MW, Bauer MS, Dennehy EB, Miklowitz DJ, Zhang HW, Ketter T, Rudorfer MV, Wisniewski SR, Thase ME, Calabrese J, Sachs GS. Demographic and diagnostic characteristics of the first 1000 patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Bipolar Disord. 2004 Dec; 6(6):460-9.
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  98. Simon NM, Otto MW, Weiss RD, Bauer MS, Miyahara S, Wisniewski SR, Thase ME, Kogan J, Frank E, Nierenberg AA, Calabrese JR, Sachs GS, Pollack MH. Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD. J Clin Psychopharmacol. 2004 Oct; 24(5):512-20.
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  99. Schneck CD, Miklowitz DJ, Calabrese JR, Allen MH, Thomas MR, Wisniewski SR, Miyahara S, Shelton MD, Ketter TA, Goldberg JF, Bowden CL, Sachs GS. Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement Program. Am J Psychiatry. 2004 Oct; 161(10):1902-8.
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  100. Tamada RS, Issler CK, Amaral JA, Sachs GS, Lafer B. Treatment emergent affective switch: a controlled study. Bipolar Disord. 2004 Aug; 6(4):333-7.
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  101. Deckersbach T, McMurrich S, Ogutha J, Savage CR, Sachs G, Rauch SL. Characteristics of non-verbal memory impairment in bipolar disorder: the role of encoding strategies. Psychol Med. 2004 Jul; 34(5):823-32.
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  102. Sachs G, Chengappa KN, Suppes T, Mullen JA, Brecher M, Devine NA, Sweitzer DE. Quetiapine with lithium or divalproex for the treatment of bipolar mania: a randomized, double-blind, placebo-controlled study. Bipolar Disord. 2004 Jun; 6(3):213-23.
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  103. Deckersbach T, Savage CR, Reilly-Harrington N, Clark L, Sachs G, Rauch SL. Episodic memory impairment in bipolar disorder and obsessive-compulsive disorder: the role of memory strategies. Bipolar Disord. 2004 Jun; 6(3):233-44.
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  104. Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP, Bowden CL, Sachs GS, Nierenberg AA. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry. 2004 May 1; 55(9):875-81.
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  105. Marangell LB, Martinez JM, Ketter TA, Bowden CL, Goldberg JF, Calabrese JR, Miyahara S, Miklowitz DJ, Sachs GS, Thase ME. Lamotrigine treatment of bipolar disorder: data from the first 500 patients in STEP-BD. Bipolar Disord. 2004 Apr; 6(2):139-43.
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  106. Tohen M, Chengappa KN, Suppes T, Baker RW, Zarate CA, Bowden CL, Sachs GS, Kupfer DJ, Ghaemi SN, Feldman PD, Risser RC, Evans AR, Calabrese JR. Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone. Br J Psychiatry. 2004 Apr; 184:337-45.
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  107. Perlis RH, Smoller JW, Fava M, Rosenbaum JF, Nierenberg AA, Sachs GS. The prevalence and clinical correlates of anger attacks during depressive episodes in bipolar disorder. J Affect Disord. 2004 Apr; 79(1-3):291-5.
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  108. Yildiz A, Sachs GS. Characteristics of rapid cycling bipolar-I patients in a bipolar speciality clinic. J Affect Disord. 2004 Apr; 79(1-3):247-51.
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  109. Deckersbach T, Perlis RH, Frankle WG, Gray SM, Grandin L, Dougherty DD, Nierenberg AA, Sachs GS. Presence of irritability during depressive episodes in bipolar disorder. CNS Spectr. 2004 Mar; 9(3):227-31.
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  110. Lembke A, Miklowitz DJ, Otto MW, Zhang H, Wisniewski SR, Sachs GS, Thase ME, Ketter TA. Psychosocial service utilization by patients with bipolar disorders: data from the first 500 participants in the Systematic Treatment Enhancement Program. J Psychiatr Pract. 2004 Mar; 10(2):81-7.
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  111. Yildiz A, Pauler DK, Sachs GS. Rates of study completion with single versus split daily dosing of antidepressants: a meta-analysis. J Affect Disord. 2004 Feb; 78(2):157-62.
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  112. Sachs GS. Strategies for improving treatment of bipolar disorder: integration of measurement and management. Acta Psychiatr Scand Suppl. 2004; (422):7-17.
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  113. Tohen M, Vieta E, Calabrese J, Ketter TA, Sachs G, Bowden C, Mitchell PB, Centorrino F, Risser R, Baker RW, Evans AR, Beymer K, Dube S, Tollefson GD, Breier A. Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression. Arch Gen Psychiatry. 2003 Nov; 60(11):1079-88.
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  114. Calabrese JR, Bowden CL, Sachs G, Yatham LN, Behnke K, Mehtonen OP, Montgomery P, Ascher J, Paska W, Earl N, DeVeaugh-Geiss J. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry. 2003 Sep; 64(9):1013-24.
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  115. Baldessarini RJ, Hennen J, Wilson M, Calabrese J, Chengappa R, Keck PE, McElroy SL, Sachs G, Vieta E, Welge JA, Yatham LN, Zarate CA, Baker RW, Tohen M. Olanzapine versus placebo in acute mania: treatment responses in subgroups. J Clin Psychopharmacol. 2003 Aug; 23(4):370-6.
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  116. Yildiz A, Sachs GS. Do antidepressants induce rapid cycling? A gender-specific association. J Clin Psychiatry. 2003 Jul; 64(7):814-8.
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  117. Yildiz A, Sachs GS, Turgay A. Pharmacological management of agitation in emergency settings. Emerg Med J. 2003 Jul; 20(4):339-46.
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  118. Thase ME, Bhargava M, Sachs GS. Treatment of bipolar depression: current status, continued challenges, and the STEP-BD approach. Psychiatr Clin North Am. 2003 Jun; 26(2):495-518.
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  119. Sachs GS. Unmet clinical needs in bipolar disorder. J Clin Psychopharmacol. 2003 Jun; 23(3 Suppl 1):S2-8.
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  120. Sachs GS, Thase ME, Otto MW, Bauer M, Miklowitz D, Wisniewski SR, Lavori P, Lebowitz B, Rudorfer M, Frank E, Nierenberg AA, Fava M, Bowden C, Ketter T, Marangell L, Calabrese J, Kupfer D, Rosenbaum JF. Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry. 2003 Jun 1; 53(11):1028-42.
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  121. Simon NM, Smoller JW, Fava M, Sachs G, Racette SR, Perlis R, Sonawalla S, Rosenbaum JF. Comparing anxiety disorders and anxiety-related traits in bipolar disorder and unipolar depression. J Psychiatr Res. 2003 May-Jun; 37(3):187-92.
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  122. Yildiz A, Sachs GS. Age onset of psychotic versus non-psychotic bipolar illness in men and in women. J Affect Disord. 2003 Apr; 74(2):197-201.
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  123. Bowden CL, Calabrese JR, Sachs G, Yatham LN, Asghar SA, Hompland M, Montgomery P, Earl N, Smoot TM, DeVeaugh-Geiss J. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry. 2003 Apr; 60(4):392-400.
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  124. Sachs GS, Rush AJ. Response, remission, and recovery in bipolar disorders: what are the realistic treatment goals? J Clin Psychiatry. 2003; 64 Suppl 6:18-22; discussion 28.
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  125. Otto MW, Reilly-Harrington N, Sachs GS. Psychoeducational and cognitive-behavioral strategies in the management of bipolar disorder. J Affect Disord. 2003 Jan; 73(1-2):171-81.
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  126. Carlson GA, Jensen PS, Findling RL, Meyer RE, Calabrese J, DelBello MP, Emslie G, Flynn L, Goodwin F, Hellander M, Kowatch R, Kusumakar V, Laughren T, Leibenluft E, McCracken J, Nottelmann E, Pine D, Sachs G, Shaffer D, Simar R, Strober M, Weller EB, Wozniak J, Youngstrom EA. Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: report of a consensus conference. J Child Adolesc Psychopharmacol. 2003; 13(1):13-27.
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  127. Sachs GS. Decision tree for the treatment of bipolar disorder. J Clin Psychiatry. 2003; 64 Suppl 8:35-40.
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  128. Zajecka JM, Weisler R, Sachs G, Swann AC, Wozniak P, Sommerville KW. A comparison of the efficacy, safety, and tolerability of divalproex sodium and olanzapine in the treatment of bipolar disorder. J Clin Psychiatry. 2002 Dec; 63(12):1148-55.
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  129. Calabrese JR, Sullivan JR, Bowden CL, Suppes T, Goldberg JF, Sachs GS, Shelton MD, Goodwin FK, Frye MA, Kusumakar V. Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management. J Clin Psychiatry. 2002 Nov; 63(11):1012-9.
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  130. Frankle WG, Perlis RH, Deckersbach T, Grandin LD, Gray SM, Sachs GS, Nierenberg AA. Bipolar depression: relationship between episode length and antidepressant treatment. Psychol Med. 2002 Nov; 32(8):1417-23.
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  131. Guille C, Sachs G. Clinical outcome of adjunctive topiramate treatment in a sample of refractory bipolar patients with comorbid conditions. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct; 26(6):1035-9.
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  132. Sachs GS, Guille C, McMurrich SL. A clinical monitoring form for mood disorders. Bipolar Disord. 2002 Oct; 4(5):323-7.
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  133. Wagner KD, Weller EB, Carlson GA, Sachs G, Biederman J, Frazier JA, Wozniak P, Tracy K, Weller RA, Bowden C. An open-label trial of divalproex in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2002 Oct; 41(10):1224-30.
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  134. Sachs GS, Grossman F, Ghaemi SN, Okamoto A, Bowden CL. Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety. Am J Psychiatry. 2002 Jul; 159(7):1146-54.
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  135. Perlis RH, Sachs GS, Lafer B, Otto MW, Faraone SV, Kane JM, Rosenbaum JF. Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry. 2002 Jul; 159(7):1155-9.
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  136. Suppes T, Dennehy EB, Swann AC, Bowden CL, Calabrese JR, Hirschfeld RM, Keck PE, Sachs GS, Crismon ML, Toprac MG, Shon SP. Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000. J Clin Psychiatry. 2002 Apr; 63(4):288-99.
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  137. Charney DS, Nemeroff CB, Lewis L, Laden SK, Gorman JM, Laska EM, Borenstein M, Bowden CL, Caplan A, Emslie GJ, Evans DL, Geller B, Grabowski LE, Herson J, Kalin NH, Keck PE, Kirsch I, Krishnan KR, Kupfer DJ, Makuch RW, Miller FG, Pardes H, Post R, Reynolds MM, Roberts L, Rosenbaum JF, Rosenstein DL, Rubinow DR, Rush AJ, Ryan ND, Sachs GS, Schatzberg AF, Solomon S. National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders. Arch Gen Psychiatry. 2002 Mar; 59(3):262-70.
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  138. Tohen M, Chengappa KN, Suppes T, Zarate CA, Calabrese JR, Bowden CL, Sachs GS, Kupfer DJ, Baker RW, Risser RC, Keeter EL, Feldman PD, Tollefson GD, Breier A. Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy. Arch Gen Psychiatry. 2002 Jan; 59(1):62-9.
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  139. Kupfer DJ, Chengappa KN, Gelenberg AJ, Hirschfeld RM, Goldberg JF, Sachs GS, Grochocinski VJ, Houck PR, Kolar AB. Citalopram as adjunctive therapy in bipolar depression. J Clin Psychiatry. 2001 Dec; 62(12):985-90.
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  140. Yýldýz A, Sachs GS. Administration of antidepressants. Single versus split dosing: a meta-analysis. J Affect Disord. 2001 Oct; 66(2-3):199-206.
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  141. Kraut JA, Helander KG, Helander HF, Iroezi ND, Marcus EA, Sachs G. Detection and localization of H+-K+-ATPase isoforms in human kidney. Am J Physiol Renal Physiol. 2001 Oct; 281(4):F763-8.
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  142. Yildiz A, Demopulos CM, Moore CM, Renshaw PF, Sachs GS. Effect of lithium on phosphoinositide metabolism in human brain: a proton decoupled (31)P magnetic resonance spectroscopy study. Biol Psychiatry. 2001 Jul 1; 50(1):3-7.
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  143. Nemeroff CB, Evans DL, Gyulai L, Sachs GS, Bowden CL, Gergel IP, Oakes R, Pitts CD. Double-blind, placebo-controlled comparison of imipramine and paroxetine in the treatment of bipolar depression. Am J Psychiatry. 2001 Jun; 158(6):906-12.
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  144. Yildiz A, Sachs GS, Dorer DJ, Renshaw PF. 31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis. Psychiatry Res. 2001 May 30; 106(3):181-91.
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  145. Sachs GS. A 25-year-old woman with bipolar disorder. JAMA. 2001 Jan 24-31; 285(4):454-62.
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  146. Sachs GS, Yan LJ, Swann AC, Allen MH. Integration of suicide prevention into outpatient management of bipolar disorder. J Clin Psychiatry. 2001; 62 Suppl 25:3-11.
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  147. Grandin LD, Yan LJ, Gray SM, Jamison KR, Sachs GS. Suicide prevention: increasing education and awareness. J Clin Psychiatry. 2001; 62 Suppl 25:12-6.
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  148. Hirschfeld RM, Williams JB, Spitzer RL, Calabrese JR, Flynn L, Keck PE, Lewis L, McElroy SL, Post RM, Rapport DJ, Russell JM, Sachs GS, Zajecka J. Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire. Am J Psychiatry. 2000 Nov; 157(11):1873-5.
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  149. Calabrese JR, Suppes T, Bowden CL, Sachs GS, Swann AC, McElroy SL, Kusumakar V, Ascher JA, Earl NL, Greene PL, Monaghan ET. A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group. J Clin Psychiatry. 2000 Nov; 61(11):841-50.
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  150. Thase ME, Sachs GS. Bipolar depression: pharmacotherapy and related therapeutic strategies. Biol Psychiatry. 2000 Sep 15; 48(6):558-72.
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  151. Sachs GS, Thase ME. Bipolar disorder therapeutics: maintenance treatment. Biol Psychiatry. 2000 Sep 15; 48(6):573-81.
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  152. Sporn J, Ghaemi SN, Sambur MR, Rankin MA, Recht J, Sachs GS, Rosenbaum JF, Fava M. Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review. Ann Clin Psychiatry. 2000 Sep; 12(3):137-40.
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  153. Bowden CL, Lecrubier Y, Bauer M, Goodwin G, Greil W, Sachs G. Maintenance therapies for classic and other forms of bipolar disorder. J Affect Disord. 2000 Sep; 59 Suppl 1:S57-S67.
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  154. Sachs GS, Koslow CL, Ghaemi SN. The treatment of bipolar depression. Bipolar Disord. 2000 Sep; 2(3 Pt 2):256-60.
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  155. Guille C, Sachs GS, Ghaemi SN. A naturalistic comparison of clozapine, risperidone, and olanzapine in the treatment of bipolar disorder. J Clin Psychiatry. 2000 Sep; 61(9):638-42.
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  156. Kahn DA, Sachs GS, Printz DJ, Carpenter D, Docherty JP, Ross R. Medication treatment of bipolar disorder 2000: a summary of the expert consensus guidelines. J Psychiatr Pract. 2000 Jul; 6(4):197-211.
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  157. Hallén S, Fryklund J, Sachs G. Inhibition of the human sodium/bile acid cotransporters by side-specific methanethiosulfonate sulfhydryl reagents: substrate-controlled accessibility of site of inactivation. Biochemistry. 2000 Jun 6; 39(22):6743-50.
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  158. Sachs GS, Printz DJ, Kahn DA, Carpenter D, Docherty JP. The Expert Consensus Guideline Series: Medication Treatment of Bipolar Disorder 2000. Postgrad Med. 2000 Apr; Spec No:1-104.
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  159. Ghaemi N, Sachs GS, Goodwin FK. What is to be done? Controversies in the diagnosis and treatment of manic-depressive illness. World J Biol Psychiatry. 2000 Apr; 1(2):65-74.
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  160. Sachs GS, Baldassano CF, Truman CJ, Guille C. Comorbidity of attention deficit hyperactivity disorder with early- and late-onset bipolar disorder. Am J Psychiatry. 2000 Mar; 157(3):466-8.
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  161. Lambrecht N, Munson K, Vagin O, Sachs G. Comparison of covalent with reversible inhibitor binding sites of the gastric H,K-ATPase by site-directed mutagenesis. J Biol Chem. 2000 Feb 11; 275(6):4041-8.
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  162. Wolfe MM, Sachs G. Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology. 2000 Feb; 118(2 Suppl 1):S9-31.
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  163. Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, Sachs G, Pisegna JR. PACAP type I receptor activation regulates ECL cells and gastric acid secretion. J Clin Invest. 1999 Nov; 104(10):1383-91.
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  164. Goldstein LE, Sporn J, Brown S, Kim H, Finkelstein J, Gaffey GK, Sachs G, Stern TA. New-onset diabetes mellitus and diabetic ketoacidosis associated with olanzapine treatment. Psychosomatics. 1999 Sep-Oct; 40(5):438-43.
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  165. Jain U, Blais MA, Otto MW, Hirshfeld DR, Sachs GS. Five-factor personality traits in patients with seasonal depression: treatment effects and comparisons with bipolar patients. J Affect Disord. 1999 Sep; 55(1):51-4.
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  166. Burt T, Sachs GS, Demopulos C. Donepezil in treatment-resistant bipolar disorder. Biol Psychiatry. 1999 Apr 15; 45(8):959-64.
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  167. Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd GD. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry. 1999 Feb; 60(2):79-88.
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  168. Ghaemi SN, Sachs GS, Chiou AM, Pandurangi AK, Goodwin K. Is bipolar disorder still underdiagnosed? Are antidepressants overutilized? J Affect Disord. 1999 Jan-Mar; 52(1-3):135-44.
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  169. Sachs GS, Guille C. Weight gain associated with use of psychotropic medications. J Clin Psychiatry. 1999; 60 Suppl 21:16-9.
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  170. Sachs GS, Gaughan S. Clinical practice guidelines: praise and problems. J Clin Psychiatry. 1999 Jan; 60(1):7-8.
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  171. Bauer MS, McBride L, Chase C, Sachs G, Shea N. Manual-based group psychotherapy for bipolar disorder: a feasibility study. J Clin Psychiatry. 1998 Sep; 59(9):449-55.
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  172. Lambrecht N, Corbett Z, Bayle D, Karlish SJ, Sachs G. Identification of the site of inhibition by omeprazole of a alpha-beta fusion protein of the H,K-ATPase using site-directed mutagenesis. J Biol Chem. 1998 May 29; 273(22):13719-28.
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  173. Melle-Milovanovic D, Milovanovic M, Nagpal S, Sachs G, Shin JM. Regions of association between the alpha and the beta subunit of the gastric H,K-ATPase. J Biol Chem. 1998 May 1; 273(18):11075-81.
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  174. Kraut JA, Hiura J, Shin JM, Smolka A, Sachs G, Scott D. The Na(+)-K(+)-ATPase beta 1 subunit is associated with the HK alpha 2 protein in the rat kidney. Kidney Int. 1998 Apr; 53(4):958-62.
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  175. Bayle D, Wängler S, Weitzenegger T, Steinhilber W, Volz J, Przybylski M, Schäfer KP, Sachs G, Melchers K. Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis. J Bacteriol. 1998 Jan; 180(2):317-29.
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  176. Sachs GS, Cosgrove VE. Bipolar disorder: current treatments and new strategies. Cleve Clin J Med. 1998; 65 Suppl 1:SI31-7; discussion SI45-7.
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  177. Vasile RG, Sachs G, Anderson JL, Lafer B, Matthews E, Hill T. Changes in regional cerebral blood flow following light treatment for seasonal affective disorder: responders versus nonresponders. Biol Psychiatry. 1997 Dec 1; 42(11):1000-5.
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  178. Lafer B, Renshaw PF, Sachs GS. Major depression and the basal ganglia. Psychiatr Clin North Am. 1997 Dec; 20(4):885-96.
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  179. Ghaemi SN, Sachs GS, Baldassano CF, Truman CJ. Insight in seasonal affective disorder. Compr Psychiatry. 1997 Nov-Dec; 38(6):345-8.
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  180. Ghaemi SN, Sachs GS. Long-term risperidone treatment in bipolar disorder: 6-month follow up. Int Clin Psychopharmacol. 1997 Nov; 12(6):333-8.
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  181. Sporn J, Sachs G. The anticonvulsant lamotrigine in treatment-resistant manic-depressive illness. J Clin Psychopharmacol. 1997 Jun; 17(3):185-9.
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  182. Kraut JA, Hiura J, Besancon M, Smolka A, Sachs G, Scott D. Effect of hypokalemia on the abundance of HK alpha 1 and HK alpha 2 protein in the rat kidney. Am J Physiol. 1997 Jun; 272(6 Pt 2):F744-50.
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  183. Ghaemi SN, Sachs GS, Baldassano CF, Truman CJ. Acute treatment of bipolar disorder with adjunctive risperidone in outpatients. Can J Psychiatry. 1997 Mar; 42(2):196-9.
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  184. Fishman SM, Catarau EM, Sachs G, Stojanovic M, Borsook D. Corticosteroid-induced mania after single regional application at the celiac plexus. Anesthesiology. 1996 Nov; 85(5):1194-6.
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  185. Stoll AL, Sachs GS, Cohen BM, Lafer B, Christensen JD, Renshaw PF. Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients. Biol Psychiatry. 1996 Sep 1; 40(5):382-8.
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  186. Sachs GS. Treatment-resistant bipolar depression. Psychiatr Clin North Am. 1996 Jun; 19(2):215-36.
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  187. Matthew E, Vasile RG, Sachs G, Anderson J, Lafer B, Hill T. Regional cerebral blood flow changes after light therapy in seasonal affective disorder. Nucl Med Commun. 1996 Jun; 17(6):475-9.
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  188. Sachs GS. Bipolar mood disorder: practical strategies for acute and maintenance phase treatment. J Clin Psychopharmacol. 1996 Apr; 16(2 Suppl 1):32S-47S.
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  189. Baldassano CF, Truman CJ, Nierenberg A, Ghaemi SN, Sachs GS. Akathisia: a review and case report following paroxetine treatment. Compr Psychiatry. 1996 Mar-Apr; 37(2):122-4.
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  190. Labbate LA, Lafer B, Thibault A, Rosenbaum JF, Sachs GS. Influence of phototherapy treatment duration for seasonal affective disorder: outcome at one vs. two weeks. Biol Psychiatry. 1995 Dec 1; 38(11):747-50.
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  191. Sachs GS, Renshaw PF, Lafer B, Stoll AL, Guimarães AR, Rosenbaum JF, Gonzalez RG. Variability of brain lithium levels during maintenance treatment: a magnetic resonance spectroscopy study. Biol Psychiatry. 1995 Oct 1; 38(7):422-8.
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  192. Weilburg JB, Schachter S, Worth J, Pollack MH, Sachs GS, Ives JR, Schomer DL. EEG abnormalities in patients with atypical panic attacks. J Clin Psychiatry. 1995 Aug; 56(8):358-62.
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  193. Sachs G, Rasoul-Rockenschaub S, Aschauer H, Spiess K, Göber I, Staffen A, Zielinski C. Lytic effector cell activity and major depressive disorder in patients with breast cancer: a prospective study. J Neuroimmunol. 1995 Jun; 59(1-2):83-9.
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  194. Kraut JA, Starr F, Sachs G, Reuben M. Expression of gastric and colonic H(+)-K(+)-ATPase in the rat kidney. Am J Physiol. 1995 Apr; 268(4 Pt 2):F581-7.
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  195. Sachs GS, Lafer B, Stoll AL, Banov M, Thibault AB, Tohen M, Rosenbaum JF. A double-blind trial of bupropion versus desipramine for bipolar depression. J Clin Psychiatry. 1994 Sep; 55(9):391-3.
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  196. Lafer B, Sachs GS, Labbate LA, Thibault A, Rosenbaum JF. Phototherapy for seasonal affective disorder: a blind comparison of three different schedules. Am J Psychiatry. 1994 Jul; 151(7):1081-3.
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  197. Labbate LA, Lafer B, Thibault A, Sachs GS. Side effects induced by bright light treatment for seasonal affective disorder. J Clin Psychiatry. 1994 May; 55(5):189-91.
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  198. Pollack MH, Otto MW, Sachs GS, Leon A, Shear MK, Deltito JA, Keller MB, Rosenbaum JF. Anxiety psychopathology predictive of outcome in patients with panic disorder and depression treated with imipramine, alprazolam and placebo. J Affect Disord. 1994 Apr; 30(4):273-81.
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  199. Labbate LA, Sachs GS. Phototherapy-induced hot flushes. J Clin Psychopharmacol. 1994 Apr; 14(2):151.
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  200. Otto MW, Pollack MH, Rosenbaum JF, Sachs GS, Asher RH. Childhood history of anxiety in adults with panic disorder: association with anxiety sensitivity and comorbidity. Harv Rev Psychiatry. 1994 Jan-Feb; 1(5):288-93.
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  201. Otto MW, Pollack MH, Sachs GS, Reiter SR, Meltzer-Brody S, Rosenbaum JF. Discontinuation of benzodiazepine treatment: efficacy of cognitive-behavioral therapy for patients with panic disorder. Am J Psychiatry. 1993 Oct; 150(10):1485-90.
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  202. González RG, Guimaraes AR, Sachs GS, Rosenbaum JF, Garwood M, Renshaw PF. Measurement of human brain lithium in vivo by MR spectroscopy. AJNR Am J Neuroradiol. 1993 Sep-Oct; 14(5):1027-37.
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  203. Keller MB, Lavori PW, Goldenberg IM, Baker LA, Pollack MH, Sachs GS, Rosenbaum JF, Deltito JA, Leon A, Shear K, et al. Influence of depression on the treatment of panic disorder with imipramine, alprazolam and placebo. J Affect Disord. 1993 May; 28(1):27-38.
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  204. Weilburg JB, Schachter S, Sachs GS, Worth J, Pollack MH, Ives JR, Schomer DL. Focal paroxysmal EEG changes during atypical panic attacks. J Neuropsychiatry Clin Neurosci. 1993; 5(1):50-5.
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  205. Stoll AL, Renshaw PF, Sachs GS, Guimaraes AR, Miller C, Cohen BM, Lafer B, Gonzalez RG. The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry. 1992 Nov 15; 32(10):944-9.
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  206. Pollack MH, Otto MW, Rosenbaum JF, Sachs GS. Personality disorders in patients with panic disorder: association with childhood anxiety disorders, early trauma, comorbidity, and chronicity. Compr Psychiatry. 1992 Mar-Apr; 33(2):78-83.
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  207. Otto MW, Pollack MH, Sachs GS, O'Neil CA, Rosenbaum JF. Alcohol dependence in panic disorder patients. J Psychiatr Res. 1992 Jan; 26(1):29-38.
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  208. Muallem S, Loessberg P, Sachs G, Wheeler LA. Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca(2+)-releasing mechanisms revealed by manoalide and benzohydroquinone. Biochem J. 1991 Oct 15; 279 ( Pt 2):367-75.
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  209. Pollack MH, Sachs GS, Tesar GE, Shushtari J, Herman JB, Otto MW, Rosenbaum JF. Pilot outreach services to homebound agoraphobic patients. Hosp Community Psychiatry. 1991 Mar; 42(3):315-7.
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  210. Tesar GE, Rosenbaum JF, Pollack MH, Otto MW, Sachs GS, Herman JB, Cohen LS, Spier SA. Double-blind, placebo-controlled comparison of clonazepam and alprazolam for panic disorder. J Clin Psychiatry. 1991 Feb; 52(2):69-76.
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  211. Zhao H, Loessberg PA, Sachs G, Muallem S. Regulation of intracellular Ca2+ oscillation in AR42J cells. J Biol Chem. 1990 Dec 5; 265(34):20856-62.
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  212. Pollack MH, Otto MW, Rosenbaum JF, Sachs GS, O'Neil C, Asher R, Meltzer-Brody S. Longitudinal course of panic disorder: findings from the Massachusetts General Hospital Naturalistic Study. J Clin Psychiatry. 1990 Dec; 51 Suppl A:12-6.
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  213. Muallem S, Zhao H, Mayer E, Sachs G. Regulation of intracellular calcium in epithelial cells. Semin Cell Biol. 1990 Aug; 1(4):305-10.
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  214. Sachs GS. Use of clonazepam for bipolar affective disorder. J Clin Psychiatry. 1990 May; 51 Suppl:31-4; discussion 50-3.
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  215. Muallem S, Khademazad M, Sachs G. The route of Ca2+ entry during reloading of the intracellular Ca2+ pool in pancreatic acini. J Biol Chem. 1990 Feb 5; 265(4):2011-6.
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  216. Sachs GS, Rosenbaum JF, Jones L. Adjunctive clonazepam for maintenance treatment of bipolar affective disorder. J Clin Psychopharmacol. 1990 Feb; 10(1):42-7.
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  217. Sachs GS, Weilburg JB, Rosenbaum JF. Clonazepam vs. neuroleptics as adjuncts to lithium maintenance. Psychopharmacol Bull. 1990; 26(1):137-43.
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  218. Weilburg JB, Rosenbaum JF, Biederman J, Sachs GS, Pollack MH, Kelly K. Fluoxetine added to non-MAOI antidepressants converts nonresponders to responders: a preliminary report. J Clin Psychiatry. 1989 Dec; 50(12):447-9.
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  219. Sachs GS. Adjuncts and alternatives to lithium therapy for bipolar affective disorder. J Clin Psychiatry. 1989 Dec; 50 Suppl:31-9; discussion 45-7.
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  220. Moser G, Kiss A, Sachs G, Spiess K, Schwarzmeier J. [The significance of psychosocial complaints in the initial interview--a study of unselected patients of an internal medicine/polyclinic university ambulatory service]. Psychother Psychosom Med Psychol. 1989 May; 39(5):161-7.
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  221. Sachs GS, Gelenberg AJ, Bellinghausen B, Wojcik J, Falk WE, Farhadi AM, Jenike M. Ergoloid mesylates and ECT. J Clin Psychiatry. 1989 Mar; 50(3):87-90.
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  222. Hoge SK, Sachs G, Appelbaum PS, Greer A, Gordon C. Limitations on psychiatrists' discretionary civil commitment authority by the Stone and dangerousness criteria. Arch Gen Psychiatry. 1988 Aug; 45(8):764-9.
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  223. Gelenberg AJ, Bellinghausen B, Wojcik JD, Falk WE, Sachs GS. A prospective survey of neuroleptic malignant syndrome in a short-term psychiatric hospital. Am J Psychiatry. 1988 Apr; 145(4):517-8.
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  224. Weilburg JB, Sachs G, Falk WE. Triazolam-induced brief episodes of secondary mania in a depressed patient. J Clin Psychiatry. 1987 Dec; 48(12):492-3.
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  225. Tesar GE, Rosenbaum JF, Pollack MH, Herman JB, Sachs GS, Mahoney EM, Cohen LS, McNamara M, Goldstein S. Clonazepam versus alprazolam in the treatment of panic disorder: interim analysis of data from a prospective, double-blind, placebo-controlled trial. J Clin Psychiatry. 1987 Oct; 48 Suppl:16-21.
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  226. Chitayat D, Hahm SY, Marion RW, Sachs GS, Goldman D, Hutcheon RG, Weiss R, Cho S, Nitowsky HM. Further delineation of the McKusick-Kaufman hydrometrocolpos-polydactyly syndrome. Am J Dis Child. 1987 Oct; 141(10):1133-6.
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  227. Weilburg JB, Bear DM, Sachs G. Three patients with concomitant panic attacks and seizure disorder: possible clues to the neurology of anxiety. Am J Psychiatry. 1987 Aug; 144(8):1053-6.
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  228. Pollack MH, Rosenbaum JF, Tesar GE, Herman JB, Sachs GS. Clonazepam in the treatment of panic disorder and agoraphobia. Psychopharmacol Bull. 1987; 23(1):141-4.
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  229. Sachs GS, Pollack MH, Brotman AW, Farhadi AM, Gelenberg AJ. Enhancement of ECT benefit by yohimbine. J Clin Psychiatry. 1986 Oct; 47(10):508-10.
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  230. Sachs G. Pump blockers and ulcer disease. N Engl J Med. 1984 Mar 22; 310(12):785-6.
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  231. Sachs G, Nutzinger D, Zapotoczky HG. [Diet triggered depression as well as its treatment: a behaviorally oriented group therapy concept]. Psychiatr Clin (Basel). 1982; 15(3):160-72.
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