Michael A. Schwarzschild, M.D., PH.D.
|Title||Associate Professor of Neurology|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
MassGeneral Inst. for Neurodegenerative Disease-Rm 3002
114 16th Street
Charlestown MA 02129
Available: 09/05/11, Expires: 09/04/14
Laboratory studies in mouse models of Parkinson's disease (PD) are conducted to better understand the role of purines -- adenosine, caffeine and urate -- in support of ongoing clinical trials.
Student would work on characterizing genetic mouse models of caffeine action (adenosine A2A receptor knockout mice) or of altered uric acid levels (Urate Oxidase knockout vs transgenic mice) in the context of Parkinson's disease models. Methods may entail neuropchemistry (mouse injections), neuropharmacology (measuring brain levels of dopamine and purine metabolites) and histology (of dopaminergic brain systems). Student would assist a laboratory investigator in the project and would have an option to accompany me to biweekly Parkinson's disease/movement disorders clinic at MGH.
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