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Sung-Yun Pai, M.D.

TitleAssistant Professor of Pediatrics
InstitutionDana-Farber Cancer Institute
DepartmentPediatrics
AddressChildren's Hospital
Karp Family Research Lab, Rm 08214
300 Longwood Ave
Boston MA 02115
Phone617/919-2508
Fax617/730-0934

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cattaneo F, Recher M, Masneri S, Baxi SN, Fiorini C, Antonelli F, Wysocki CA, Calderon JG, Eibel H, Smith AR, Bonilla FA, Tsitsikov E, Giliani S, Notarangelo LD, Pai SY. Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment. J Allergy Clin Immunol. 2013 Apr; 131(4):1136-45.
    View in: PubMed
  2. Tai TS, Pai SY, Ho IC. GATA-3 Regulates the Homeostasis and Activation of CD8+ T Cells. J Immunol. 2013 Jan 1; 190(1):428-37.
    View in: PubMed
  3. Kohn DB, Pai SY, Sadelain M. Gene therapy through autologous transplantation of gene-modified hematopoietic stem cells. Biol Blood Marrow Transplant. 2013 Jan; 19(1 Suppl):S64-9.
    View in: PubMed
  4. Henderson LA, Frugoni F, Hopkins G, Al-Herz W, Weinacht K, Comeau AM, Bonilla FA, Notarangelo LD, Pai SY. First reported case of Omenn syndrome in a patient with reticular dysgenesis. J Allergy Clin Immunol. 2013 Apr; 131(4):1227-1230.e3.
    View in: PubMed
  5. Recher M, Berglund LJ, Avery DT, Cowan MJ, Gennery AR, Smart J, Peake J, Wong M, Pai SY, Baxi S, Walter JE, Palendira U, Tangye GA, Rice M, Brothers S, Al-Herz W, Oettgen H, Eibel H, Puck JM, Cattaneo F, Ziegler JB, Giliani S, Tangye SG, Notarangelo LD. IL-21 is the primary common ? chain-binding cytokine required for human B-cell differentiation in vivo. Blood. 2011 Dec 22; 118(26):6824-35.
    View in: PubMed
  6. Chan K, Davis J, Pai SY, Bonilla FA, Puck JM, Apkon M. A Markov model to analyze cost-effectiveness of screening for severe combined immunodeficiency (SCID). Mol Genet Metab. 2011 Nov; 104(3):383-9.
    View in: PubMed
  7. Moratto D, Giliani S, Bonfim C, Mazzolari E, Fischer A, Ochs HD, Cant AJ, Thrasher AJ, Cowan MJ, Albert MH, Small T, Pai SY, Haddad E, Lisa A, Hambleton S, Slatter M, Cavazzana-Calvo M, Mahlaoui N, Picard C, Torgerson TR, Burroughs L, Koliski A, Neto JZ, Porta F, Qasim W, Veys P, Kavanau K, Hönig M, Schulz A, Friedrich W, Notarangelo LD. Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study. Blood. 2011 Aug 11; 118(6):1675-84.
    View in: PubMed
  8. de la Fuente MA, Recher M, Rider NL, Strauss KA, Morton DH, Adair M, Bonilla FA, Ochs HD, Gelfand EW, Pessach IM, Walter JE, King A, Giliani S, Pai SY, Notarangelo LD. Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia. J Allergy Clin Immunol. 2011 Jul; 128(1):139-46.
    View in: PubMed
  9. McDonald DR, Massaad MJ, Johnston A, Keles S, Chatila T, Geha RS, Pai SY. Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1304-5.e3.
    View in: PubMed
  10. Hale JE, Bonilla FA, Pai SY, Gerstel-Thompson JL, Notarangelo LD, Eaton RB, Comeau AM. Identification of an infant with severe combined immunodeficiency by newborn screening. J Allergy Clin Immunol. 2010 Nov; 126(5):1073-4.
    View in: PubMed
  11. Gerstel-Thompson JL, Wilkey JF, Baptiste JC, Navas JS, Pai SY, Pass KA, Eaton RB, Comeau AM. High-throughput multiplexed T-cell-receptor excision circle quantitative PCR assay with internal controls for detection of severe combined immunodeficiency in population-based newborn screening. Clin Chem. 2010 Sep; 56(9):1466-74.
    View in: PubMed
  12. Comeau AM, Hale JE, Pai SY, Bonilla FA, Notarangelo LD, Pasternack MS, Meissner HC, Cooper ER, DeMaria A, Sahai I, Eaton RB. Guidelines for implementation of population-based newborn screening for severe combined immunodeficiency. J Inherit Metab Dis. 2010 Oct; 33(Suppl 2):S273-81.
    View in: PubMed
  13. Pai SY, Notarangelo LD. Hematopoietic cell transplantation for Wiskott-Aldrich syndrome: advances in biology and future directions for treatment. Immunol Allergy Clin North Am. 2010 May; 30(2):179-94.
    View in: PubMed
  14. Debelenko LV, Perez-Atayde AR, Dubois SG, Grier HE, Pai SY, Shamberger RC, Kozakewich HP. p53+/mdm2- atypical lipomatous tumor/well-differentiated liposarcoma in young children: an early expression of Li-Fraumeni syndrome. Pediatr Dev Pathol. 2010 May-Jun; 13(3):218-24.
    View in: PubMed
  15. Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HR. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51.
    View in: PubMed
  16. Pai SY, Kim C, Williams DA. Rac GTPases in human diseases. Dis Markers. 2010; 29(3-4):177-87.
    View in: PubMed
  17. Pei XH, Bai F, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y. CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell. 2009 May 5; 15(5):389-401.
    View in: PubMed
  18. Sheehan WJ, Delmonte OM, Miller DT, Roberts AE, Bonilla FA, Morra M, Giliani S, Pai SY, Notarangelo LD, Oettgen HC. Novel presentation of Omenn syndrome in association with aniridia. J Allergy Clin Immunol. 2009 Apr; 123(4):966-9.
    View in: PubMed
  19. Ho IC, Tai TS, Pai SY. GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 2009 Feb; 9(2):125-35.
    View in: PubMed
  20. Permaul P, Narla A, Hornick JL, Pai SY. Allogeneic hematopoietic stem cell transplantation for X-linked ectodermal dysplasia and immunodeficiency: case report and review of outcomes. Immunol Res. 2009; 44(1-3):89-98.
    View in: PubMed
  21. Sung-Yun Pai and Barbara E. Bierer. Cell-Mediated and Humoral Immunity and the Regulation of Immune Responses. Nathan and Oski's Hematology of Infancy and Childhood. 2008.
  22. Pai SY, Levy O, Jabara HH, Glickman JN, Stoler-Barak L, Sachs J, Nurko S, Orange JS, Geha RS. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1113-1118.e1.
    View in: PubMed
  23. Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, Egeblad M, Ewald AJ, Pai SY, Ho IC, Werb Z. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell. 2008 Feb; 13(2):141-52.
    View in: PubMed
  24. Pai SY, Kang BY, Sabadini AM, Parisini E, Truitt ML, Ho IC. Distinct structural requirements of GATA-3 for the regulation of thymocyte and Th2 cell differentiation. J Immunol. 2008 Jan 15; 180(2):1050-9.
    View in: PubMed
  25. Pai SY, Kang BY, Sabadini A , Parisini E, Truitt ML, Ho IC. Distinct Structural Requirements of GATA-3 for the Regulation of Thymocyte and Th2 Cell Differentiation. Journal of Immunology. 2008; 180:1050-1059.
  26. Pai SY, Levy O, Jabara HH, Glickman JN, Sachs J, Nurko S, Orange JS, Geha RS. Successful correction of immune defects in a patient with NEMO mutation by allogeneic transplantation uncovers intrinsic epithelial basis for colitis. Journal of Allergy and Clinical Immunology. 2008.
  27. Jennifer M. Puck, SCID Newborn Screening Working Group. Population-based newborn screening for severe combined immunodeficiency: steps toward implementation. J Allergy Clin Immunol. 2007; 120(4):760-8.
  28. Ho IC, Pai SY. GATA-3 - not just for Th2 cells anymore. Cell Mol Immunol. 2007 Feb; 4(1):15-29.
    View in: PubMed
  29. de Guzman Strong C, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T, Millar SE, Ho IC, Pai SY, Segre JA. Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol. 2006 Nov 20; 175(4):661-70.
    View in: PubMed
  30. Strong CD, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T, Millar SE, Ho IC, Pai SY, Segre JA. Lipid Defect Underlies Selective Barrier Deficiency in an Epidermal-specific Deletion of Gata-3. J Cell Biol. 2006; 175(4):661-670.
  31. Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC. GATA-3 regulates the development and function of invariant NKT cells. J Immunol. 2006 Nov 15; 177(10):6650-9.
    View in: PubMed
  32. Pai SY, DeMartiis D, Forino C, Cavagnini S, Lanfranchi A, Giliani S, Moratto D, Mazza C, Porta F, Imberti L, Notarangelo LD, Mazzolari E. Stem cell transplantation for the Wiskott-Aldrich syndrome: a single-center experience confirms efficacy of matched unrelated donor transplantation. Bone Marrow Transplant. 2006 Nov; 38(10):671-9.
    View in: PubMed
  33. Pai SY, Truitt ML, Ho IC. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):1993-8.
    View in: PubMed
  34. Pai SY, Truitt ML, Ting CN, Leiden JM, Glimcher LH, Ho IC. GATA-3 has multiple roles in thymocyte development. Keystone Symposia: T Cell Development for Oral Presentation. 2004.
  35. Pai SY, Truitt ML, Ting CN, Leiden JM, Glimcher LH, Ho IC. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 2003 Dec; 19(6):863-75.
    View in: PubMed
  36. Pai SY, Ho IC. c-Rel delivers a one-two punch in Th1 cell differentiation. J Clin Invest. 2002 Sep; 110(6):741-2.
    View in: PubMed
  37. Fruman DA, Pai SY, Klee CB, Burakoff SJ, Bierer BE. Measurement of Calcineurin Phosphatase Activity in Cell Extracts Methods. 1996 Apr; 9(2):146-54.
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  38. Fruman DA, Pai SY, Burakoff SJ, Bierer BE. Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells. Mol Cell Biol. 1995 Jul; 15(7):3857-63.
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  39. Pai SY, Fruman DA, Leong T, Neuberg D, Rosano TG, McGarigle C, Antin JH, Bierer BE. Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A. Blood. 1994 Dec 1; 84(11):3974-9.
    View in: PubMed
  40. Pai SY, Calvo V, Wood M, Bierer BE. Cross-linking CD28 leads to activation of 70-kDa S6 kinase. Eur J Immunol. 1994 Oct; 24(10):2364-8.
    View in: PubMed
  41. Pai SY, Calvo V, Wood M, Bierer BE. Cross-linking CD28 leads to activation of 70-kDa S6 kinase. Oral Presentation, American Society of Hematology. 1993; 82(11).
  42. Pai SY, Fruman DA, Leong T, Neuberg D, Rosano TG, McGarigle C, Antin JH, Bierer BE. Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A. Oral Presentation, American Society of Hematology. 1993; 82(11).
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