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Kun Hu, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Sleep Medicine-036 BLI
221 Longwood Ave
Boston MA 02115
Phone617/525-8694
Fax617/732-7337

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hu K, Harper DG, Shea SA, Stopa EG, Scheer FA. Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia. Sci Rep. 2013 Jul 18; 3:2229.
    View in: PubMed
  2. Zhou J, Manor B, Liu D, Hu K, Zhang J, Fang J. The Complexity of Standing Postural Control in Older Adults: A Modified Detrended Fluctuation Analysis Based upon the Empirical Mode Decomposition Algorithm. PLoS One. 2013; 8(5):e62585.
    View in: PubMed
  3. Pittman-Polletta BR, Scheer FA, Butler MP, Shea SA, Hu K. The role of the circadian system in fractal neurophysiological control. Biol Rev Camb Philos Soc. 2013 Nov; 88(4):873-94.
    View in: PubMed
  4. Hu K, Meijer JH, Shea SA, Vanderleest HT, Pittman-Polletta B, Houben T, van Oosterhout F, Deboer T, Scheer FA. Fractal Patterns of Neural Activity Exist within the Suprachiasmatic Nucleus and Require Extrinsic Network Interactions. PLoS One. 2012; 7(11):e48927.
    View in: PubMed
  5. Aoi MC, Hu K, Lo MT, Selim M, Olufsen MS, Novak V. Impaired cerebral autoregulation is associated with brain atrophy and worse functional status in chronic ischemic stroke. PLoS One. 2012; 7(10):e46794.
    View in: PubMed
  6. Hu K, Lo MT, Peng CK, Liu Y, Novak V. A nonlinear dynamic approach reveals a long-term stroke effect on cerebral blood flow regulation at multiple time scales. PLoS Comput Biol. 2012; 8(7):e1002601.
    View in: PubMed
  7. Manor BD, Hu K, Peng CK, Lipsitz LA, Novak V. Posturo-respiratory synchronization: effects of aging and stroke. Gait Posture. 2012 Jun; 36(2):254-9.
    View in: PubMed
  8. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Mar 1; 483(7387):96-9.
    View in: PubMed
  9. Rissanen SM, Kankaanpää M, Tarvainen MP, Novak V, Novak P, Hu K, Manor B, Airaksinen O, Karjalainen PA. Analysis of EMG and acceleration signals for quantifying the effects of deep brain stimulation in Parkinson's disease. IEEE Trans Biomed Eng. 2011 Sep; 58(9):2545-53.
    View in: PubMed
  10. Shea SA, Hilton MF, Hu K, Scheer FA. Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening. Circ Res. 2011 Apr 15; 108(8):980-4.
    View in: PubMed
  11. Hu K, Scheer FA, Laker M, Smales C, Shea SA. Endogenous circadian rhythm in vasovagal response to head-up tilt. Circulation. 2011 Mar 8; 123(9):961-70.
    View in: PubMed
  12. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20541-6.
    View in: PubMed
  13. Manor B, Costa MD, Hu K, Newton E, Starobinets O, Kang HG, Peng CK, Novak V, Lipsitz LA. Physiological complexity and system adaptability: evidence from postural control dynamics of older adults. J Appl Physiol. 2010 Dec; 109(6):1786-91.
    View in: PubMed
  14. Lin LY, Lo MT, Ko PC, Lin C, Chiang WC, Liu YB, Hu K, Lin JL, Chen WJ, Ma MH. Detrended fluctuation analysis predicts successful defibrillation for out-of-hospital ventricular fibrillation cardiac arrest. Resuscitation. 2010 Mar; 81(3):297-301.
    View in: PubMed
  15. Novak V, Hu K, Desrochers L, Novak P, Caplan L, Lipsitz L, Selim M. Cerebral flow velocities during daily activities depend on blood pressure in patients with chronic ischemic infarctions. Stroke. 2010 Jan; 41(1):61-6.
    View in: PubMed
  16. Lo MT, Novak V, Peng CK, Liu Y, Hu K. Nonlinear phase interaction between nonstationary signals: a comparison study of methods based on Hilbert-Huang and Fourier transforms. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jun; 79(6 Pt 1):061924.
    View in: PubMed
  17. Lo M-T, Novak V, Peng CK, Liu Y, Hu K. Assessment of nonlinear phase interaction between nonstationary signals: A comparison study of methods based on Hilbert-Huang and Fourier transforms. Phys Rev E. 2009; in press.
  18. Hu K, Van Someren E,JW Shea SA, Scheer FAJL. Reduction of scale-invariance of activity fluctuations with aging and Alzheimer's disease: involvement of the circadian pacemaker. Proc Natl Acad Sci. 2009; 106(8):2490-2494.
  19. Novak V, Haertle M, Zhao P, Hu K, Munshi M, Novak P, Abduljalil A, Alsop D. White matter hyperintensities and dynamics of postural control. Magn Reson Imaging. 2009 Jul; 27(6):752-9.
    View in: PubMed
  20. Zhao P, Alsop DC, Abduljalil A, Selim M, Lipsitz L, Novak P, Caplan L, Hu K, Novak V. Vasoreactivity and peri-infarct hyperintensities in stroke. Neurology. 2009 Feb 17; 72(7):643-9.
    View in: PubMed
  21. Hu K, Lo MT, Peng CK, Novak V, Schmidt EA, Kumar A, Czosnyka M. Nonlinear pressure-flow relationship is able to detect asymmetry of brain blood circulation associated with midline shift. J Neurotrauma. 2009 Feb 11; 26(2):227-33.
    View in: PubMed
  22. Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2490-4.
    View in: PubMed
  23. Shea SA, Hu K, Scheer FA. Endogenous circadian rhythm of activity in humans. Sleep. 2008; 31:A46.
  24. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hahn M, Laker MD, Patel Y, Smales C, Shea SA. Influence of endogenous circadian system, physical exercise, and their interaction on cardiovascular risk factors. Sleep. 2008; 31:A46.
  25. Hu K, Van Someren E, Shea SA, Scheer FA. Reduction of scale-invariant activity control with aging and Alzheimer's disease: Possible involvement of the circadian pacemaker in multiscale regulation of human activity. Sleep. 2008; 31:A46-A47.
  26. Hu K, Scheer FA, Buijs RM, Shea SA. The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats. Cardiovasc Res. 2008 Oct 1; 80(1):62-8.
    View in: PubMed
  27. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Doamekpor LA, Laker MD, Patel Y, Smales C, Shea SA . Additive influences of the endogenous circadian system and mental stress on cardiovascular risk factors. Sleep. 2008; 31:A51-A52.
  28. Hu K, Scheer FA, Evoniuk H, Kelly E, Laker M, Smales C, Shea SA. Influences of postural tilt stress and the circadian system on cardiovascular risk factors. Sleep. 2008; 31:A25.
  29. Hu K, Scheer FA, Buijs RM, Shea SA. The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2008 Jun; 23(3):265-73.
    View in: PubMed
  30. Hu K, Peng CK, Czosnyka M, Zhao P, Novak V. Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral blood flow fluctuations. Cardiovasc Eng. 2008 Mar; 8(1):60-71.
    View in: PubMed
  31. Hu K, Scheer FAJL, Buijs RM, Shea SA. The Circadian Pacemaker Generates an Endogenous Circadian Rhythm in the Fractal Structure of Heart Rate in Nocturnal Rats. Cardiovascular Research. 2008; in press.
  32. Lo M-T, Hu K., Liu Y, Peng CK, Novak V. Multimodal Pressure Flow Analysis Enables Assessment of Cerebral Autoregulation Dynamics During Baseline Resting Conditions. Journal on Advances in Signal Processing. 2008; Accepted..
  33. Hu K, Peng CK, Huang NE, Wu Z, Lipsitz LA, Cavallerano J, Novak V. Altered Phase Interactions between Spontaneous Blood Pressure and Flow Fluctuations in Type 2 Diabetes Mellitus: Nonlinear Assessment of Cerebral Autoregulation. Physica A. 2008; 387(10):2279-2292.
  34. Ivanov PCh, Hu K, Hilton MF, Shea SA, Stanley HE. Endogenous circadian rhythms in human motor activity uncoupled from circadian influences on cardiac dynamics. Proc Natl Acad Sci. 2007; 104(52):20702-20707.
  35. Ivanov PCh, Hu K, Hilton MF, Shea SA, Stanley HE. Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20702-7.
    View in: PubMed
  36. Hu K, Scheer FA, Ivanov PCh, Buijs RM, Shea SA. The suprachiasmatic nucleus functions beyond circadian rhythm generation. Neuroscience. 2007 Nov 9; 149(3):508-17.
    View in: PubMed
  37. Last D, Alsop DC, Abduljalil AM, Marquis RP, de Bazelaire C, Hu K, Cavallerano J, Novak V. Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity. Diabetes Care. 2007 May; 30(5):1193-9.
    View in: PubMed
  38. Novak V, Hu K, Vyas M, Lipsitz LA. Cardio-Locomotor Coupling in Young and Old. Journals of Gerontology. 2007; 62:86-92..
  39. Hu K, Peng CK, Czosnyka M, Novak V . Assessment of impairment of dynamic cerebral autoregulation after traumatic brain injury using multimodal pressure flow analysis. Neurology. 2007; 68(12):A392 Suppl.1.
  40. Selim MH, Jones RN, Hu K, Novak P, Novak V. Gender differences in cerebral hemodynamics in patients with diabetes, hypertension, and stroke: A transcranial Doppler ultrasound study. Stroke. 2007; 38:567.
  41. Hu K, Peng CK, Czosnyka M, Zhao P, Novak V. Nonlinear Assessment of Cerebral Autoregulation from Spontaneous Blood Pressure and Cerebral Perfusion Pressure Fluctuations. Cardiovascular Engineering. 2007; in Press..
  42. Hu K, Peng CK, Huang N, Wu Z, Lipsitz LA, Novak V. Assessment Of Impaired Cerebral Blood Flow Regulation in Type 2 Diabetes Mellitus Using Multimodal Pressure Flow Analysis. Diabetes. 2007; 56:A585 Suppl. 1.
  43. Shea SA, Hu K, Buijs RM, Scheer FAJL. Lesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in rats. SLEEP. 2007; 30:A58 168 Suppl. S.
  44. Hu K, Scheer FAJL, Buijs RM, Shea SA. The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2007; Accepted..
  45. Zhao P, Haertle M, Hu K, Larose S, Abdulajlil A, Alsop D, Novak V. Effects of white matter hyperintensities on balance in elderly with type 2 diabetes and hypertension. Diabetes. 2007; 56:A171 Suppl. 1.
  46. Novak V, Hu K, Vyas M, Lipsitz LA. Cardiolocomotor coupling in young and elderly people. J Gerontol A Biol Sci Med Sci. 2007 Jan; 62(1):86-92.
    View in: PubMed
  47. Hu K, Scheer FAJL, Buijs RM, Shea SA. Effect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuations. SLEEP. 2007; 30:A64 186 Suppl. S.
  48. Novak V, Last D, Alsop DC, Abduljalil AM, Hu K, Lepicovsky L, Cavallerano J, Lipsitz LA. Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes. Diabetes Care. 2006 Jul; 29(7):1529-34.
    View in: PubMed
  49. Xu L, Chen Z, Hu K, Stanley HE, Ivanov PCh. Spurious detection of phase synchronization in coupled nonlinear oscillators. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun; 73(6 Pt 2):065201.
    View in: PubMed
  50. Chen Z, Hu K, Stanley HE, Novak V, Ivanov PCh. Cross-correlation of instantaneous phase increments in pressure-flow fluctuations: applications to cerebral autoregulation. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Mar; 73(3 Pt 1):031915.
    View in: PubMed
  51. Hu K, Hilton MF, Ayers R, Ivanov PCh, Shea SA. An endogenous circadian rhythm in an index of cardiac vulnerability confirmed with a constant routine protocol. Sleep. 2006; 29:A68 202 Suppl. S.
  52. Chen Z, Hu K, Stanley HE, Novak V, Ivanov PCh. Cross-correlation of instantaneous phase increments in pressure-flow fluctuations: Applications to cerebral autoregulation. Phys Rev E. 2006; 73:031915..
  53. Hu K, Scheer FAJL, Ivanov PCh, Buijs RM, Shea SA. Intrinsic scale-invariant patterns of locomotor activity: Influence of the circadian pacemaker across a wide range of time scales - Spanning 4-24 hours. Sleep. 2006; 29:A64 190 Suppl. S.
  54. Hu K, Peng CK, Last D, Novak V. Age and gender effects on postural control dynamics assessed by stabilogram-diffusion analysis. Diabetes. 2006; 55:A579.
  55. Xu L, Chen Z, Hu K, Stanley HE, Ivanov PCh. Spurious detection of phase synchronization in coupled nonlinear oscillators. Phys Rev E. 2006; 74:065201..
  56. Robles CA, Hu K, Last D, Lepicovsky L, Novak P, Novak V. Effects of type 2 diabetes mellitus on foot pressure distribution during walking. Diabetes. 2006; 55:A543..
  57. Novak V, Last D, Alsop DC, Abduljalil AM, Hu K, Lepicovaky L, Cavallerano J, Lipsitz LA. Cerebral Blood Flow and White Matter Hyperintensities in Type 2 Diabetes Mellitus. Diabetes Care. 2006; 29:1529-34..
  58. Hessert MJ, Vyas M, Leach J, Hu K, Lipsitz LA, Novak V. Foot pressure distribution during walking in young and old adults. BMC Geriatr. 2005; 5:8.
    View in: PubMed
  59. Xu L, Ivanov PCh, Hu K, Chen Z, Carbone A, Stanley HE. Quantifying signals with power-law correlations: a comparative study of detrended fluctuation analysis and detrended moving average techniques. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 May; 71(5 Pt 1):051101.
    View in: PubMed
  60. Hu K, Ivanov PCh, Chen Z, Stanley HE, Hilton MF, Shea SA. Circadian rhythms and fractal fluctuations in forearm motion. APS March Meeting, March 24, 2005; Los Angeles, CA. APS March Meeting, Los Angeles, CA. 2005; V22.00008.
  61. Chen Z, Hu K, Carpena P, Bernaola-Galvan P, Stanley HE, Ivanov PCh. Effect of nonlinear filters on detrended fluctuation analysis. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jan; 71(1 Pt 1):011104.
    View in: PubMed
  62. Hu Kun. Statistical physics approaches to understanding physiological fluctuations. 2005.
  63. Xu L, Ivanov PCh, Hu K, Chen Z, Carbone A, Stanley HE. Quantifying signals with power-law correlations: A comparative study of detrended fluctuation analysis and detrended moving average techniques. Phys Rev E. 2005; 71:851101..
  64. Chen Z, Hu K, Carpena P, Bernaola-Galvan P, Stanley HE, Ivanov PCh. Effect of nonlinearity on detrended fluctuation analysis. Physical Review E. 2005; 71:011104.
  65. Hu K, Ivanov PCh, Hilton MF, Chen Z, Ayers RT, Stanley HE, Shea SA. Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18223-7.
    View in: PubMed
  66. Angelini L, de Tommaso M, Guido M, Hu K, Ivanov PCh, Marinazzo D, Nardulli G, Nitti L, Pellicoro M, Pierro C, Stramaglia S. Steady-state visual evoked potentials and phase synchronization in migraine patients. Phys Rev Lett. 2004 Jul 16; 93(3):038103.
    View in: PubMed
  67. Hu K, Ivanov PCh, Chen Z, Hilton MF, Stanley HE, Shea SA. Non-random fluctuations and multi-scale dynamics regulation of human activity. Physica A. 2004 Jun; 337(1-2):307-18.
    View in: PubMed
  68. Stramaglia S, Angelini L, Pellicoro M, Hu K, Ivanov PCh. EEG synchronization and migraine. APS March Meeting; Montreal, Quebec, Canada. 2004; W9.001.
  69. Ivanov PCh, Chen Z, Hu K, Stanley HE. Multiscale aspects of cardiac control. Physica A. 2004; 344:685-704..
  70. Hu K, Ivanov PCh, Hilton MF, Chen Z, Ayers RT, Stanley HE, Shea SA. Endogenous circadian rhythms in an index of cardiac vulnerability independent of changes in behavior. Proc Natl Acad Sci. 2004; 101:18223-7..
  71. Ivanov PCh, Hu K, Dammers J, Fieseler T, Tass PA. Detection of hierarchies and complex networks in cerebral synchronization patterns. APS March Meeting, Austin, TX. 2003; N15.012.
  72. Chen Z, Ivanov PCh, Hu K, Stanley HE, Novak V. Synchronization patterns in cerebral blood flow and peripheral blood pressure after a minor stroke. Noise in Complex Systems and Stochastic Dynamics. 2003; 5114:498-506.
  73. Hu K, Ivanov PCh, Chen Z, Hilton MF, Stanley HE, Shea SA. Novel multiscale regulation in human motor activity. Noise in Complex Systems and Stochastic Dynamics. 2003; 5110:235-43.
  74. Chen Z, Ivanov PCh, Hu K, Stanley HE. Effect of nonstationarities on detrended fluctuation analysis. Physical Review E. 2002; 65:041107..
  75. Hu K, Ivanov PCh, Chen Z, Carpena P, Stanley HE. Effect of trends on detrended fluctuation analysis. Physical Review E. 2001; 64:011114..
  76. Karbach M, Hu K, Muller G, Tobochnik J. Computer simulations ---Introduction to the Bethe ansatz II. Computers in Physics. 1998; 12(6):565-73..
  77. Sun X, Xu XH, Hu K, Yonemitsu K. Effect of electron correlation on competition between BOW and SDW in polymer. Physics Letters A. 1998; 239(3):191-5..
  78. Xu XH, Fu RT, Hu K, Sun X, Yonemitsu K. Off-diagonal interactions and spin-density waves in polymers. Physical Review B. 1998; 58(14):9039-46..
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