 Charles R. Vanderburg, PH.D.
| Title | Instructor in Neurology |
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| Institution | Massachusetts General Hospital |
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| Department | Neurology |
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| Address | Massachusetts General Hospital
Department of Neurology, 2725D
114 16th Street
Charlestown MA 02129
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| Phone | 617/726-6389 |
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| Fax | 617/724-2659 |
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 Overview Following fellowships at Harvard Medical School and Massachusetts General Hospital, Dr. Vanderburg joined the Harvard NeuroDiscovery Center as the director of the Advanced Tissue Resource Center at the MassGeneral Institute for Neurodegenerative Disease. Dr. Vanderburg has published on a wide range of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, autism, and bipolar disorder. His current research focus is on the microgenomic and microproteomic profiling of human neuropathological tissue specimens and their derivatives, including miRNAs and exosomes. With a focus on developing artifact-control methodologies for such specimens, the lab is actively investigating novel bioinformatic strategies and technologies.
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Banigan MG, Kao PF, Kozubek JA, Winslow AR, Medina J, Costa J, Schmitt A, Schneider A, Cabral H, Cagsal-Getkin O, Vanderburg CR, Delalle I. Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients. PLoS One. 2013; 8(1):e48814.
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Hu B, Jiang G, Pang C, Wang S, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Deng Y, Huang X. Assessment of gene order computing methods for Alzheimer's disease. BMC Med Genomics. 2013; 6 Suppl 1:S8.
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Vanderburg CR, Clarke MS. Laser capture microdissection of metachromatically stained skeletal muscle allows quantification of fiber type specific gene expression. Mol Cell Biochem. 2013 Mar; 375(1-2):159-70.
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Danzer KM, Kranich LR, Ruf WP, Cagsal-Getkin O, Winslow AR, Zhu L, Vanderburg CR, McLean PJ. Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol Neurodegener. 2012; 7:42.
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Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol. 2012 Jul; 71(7):654-64.
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Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E128-35.
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Unni VK, Ebrahimi-Fakhari D, Vanderburg CR, McLean PJ, Hyman BT. Studying protein degradation pathways in vivo using a cranial window-based approach. Methods. 2011 Mar; 53(3):194-200.
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Kao PF, Davis DA, Banigan MG, Vanderburg CR, Seshadri S, Delalle I. Modulators of cytoskeletal reorganization in CA1 hippocampal neurons show increased expression in patients at mid-stage Alzheimer's disease. PLoS One. 2010; 5(10):e13337.
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Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT. Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. J Biol Chem. 2010 Oct 8; 285(41):31217-32.
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Pang CY, Hu W, Hu BQ, Shi Y, Vanderburg CR, Rogers JT, Huang X. A special local clustering algorithm for identifying the genes associated with Alzheimer's disease. IEEE Trans Nanobioscience. 2010 Mar; 9(1):44-50.
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Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009 Feb 27; 323(5918):1205-8.
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Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X. Independent component analysis of Alzheimer's DNA microarray gene expression data. Mol Neurodegener. 2009; 4:5.
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Ferland RJ, Batiz LF, Neal J, Lian G, Bundock E, Lu J, Hsiao YC, Diamond R, Mei D, Banham AH, Brown PJ, Vanderburg CR, Joseph J, Hecht JL, Folkerth R, Guerrini R, Walsh CA, Rodriguez EM, Sheen VL. Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia. Hum Mol Genet. 2009 Feb 1; 18(3):497-516.
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Kong W, Vanderburg CR, Gunshin H, Rogers JT, Huang X. A review of independent component analysis application to microarray gene expression data. Biotechniques. 2008 Nov; 45(5):501-20.
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Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, Standaert DG, Irizarry MC, Hyman BT. No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain. Acta Neuropathol. 2006 Oct; 112(4):439-49.
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Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. J Struct Biol. 2006 Jul; 155(1):45-51.
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Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT, Ingelsson M. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp Neurol. 2005 Jul; 194(1):91-6.
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Carterson AJ, Höner zu Bentrup K, Ott CM, Clarke MS, Pierson DL, Vanderburg CR, Buchanan KL, Nickerson CA, Schurr MJ. A549 lung epithelial cells grown as three-dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis. Infect Immun. 2005 Feb; 73(2):1129-40.
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Clarke MS, Vanderburg CR, Feeback DL. The effect of acute microgravity on mechanically-induced membrane damage and membrane-membrane fusion events. J Gravit Physiol. 2001 Dec; 8(2):37-47.
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Nickerson CA, Goodwin TJ, Terlonge J, Ott CM, Buchanan KL, Uicker WC, Emami K, LeBlanc CL, Ramamurthy R, Clarke MS, Vanderburg CR, Hammond T, Pierson DL. Three-dimensional tissue assemblies: novel models for the study of Salmonella enterica serovar Typhimurium pathogenesis. Infect Immun. 2001 Nov; 69(11):7106-20.
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Clarke MS, Vanderburg CR, Bamman MM, Caldwell RW, Feeback DL. In situ localization of cholesterol in skeletal muscle by use of a monoclonal antibody. J Appl Physiol. 2000 Aug; 89(2):731-41.
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Sun D, Vanderburg CR, Odierna GS, Hay ED. TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro. Development. 1998 Jan; 125(1):95-105.
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Vanderburg CR, Hay ED. E-cadherin transforms embryonic corneal fibroblasts to stratified epithelium with desmosomes. Acta Anat (Basel). 1996; 157(2):87-104.
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Clarke MS, Vanderburg CR, Hay ED, McNeil PL. Cytoplasmic loading of dyes, protein and plasmid DNA using an impact-mediated procedure. Biotechniques. 1994 Dec; 17(6):1118-25.
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Vanderburg CR, Nathanson MA. Posttranscriptional control of embryonic rat skeletal muscle protein synthesis. Control at the level of translation by endogenous RNA. J Cell Biol. 1988 Sep; 107(3):1085-98.
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Nathanson MA, Bush EW, Vanderburg C. Transcriptional-translational regulation of muscle-specific protein synthesis and its relationship to chondrogenic stimuli. J Biol Chem. 1986 Jan 25; 261(3):1477-86.
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