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Charles R. Vanderburg, PH.D.

TitleInstructor in Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Department of Neurology, 2725D
114 16th Street
Charlestown MA 02129
Phone617/726-6389
Fax617/724-2659

 Overview 
 overview
Following fellowships at Harvard Medical School and Massachusetts General Hospital, Dr. Vanderburg joined the Harvard NeuroDiscovery Center as the director of the Advanced Tissue Resource Center at the MassGeneral Institute for Neurodegenerative Disease. Dr. Vanderburg has published on a wide range of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, autism, and bipolar disorder. His current research focus is on the microgenomic and microproteomic profiling of human neuropathological tissue specimens and their derivatives, including miRNAs and exosomes. With a focus on developing artifact-control methodologies for such specimens, the lab is actively investigating novel bioinformatic strategies and technologies.


 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Harvard NeuroDiscovery Center - Advanced Tissue Resource Center (HMS) - Core services (5), Instruments (9), Primers (45) and Protocols (9)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Clarke MS, Sundaresan A, Vanderburg CR, Banigan MG, Pellis NR. A three-dimensional tissue culture model of bone formation utilizing rotational co-culture of human adult osteoblasts and osteoclasts. Acta Biomater. 2013 Aug; 9(8):7908-16.
    View in: PubMed
  2. Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet. 2013 Aug 1; 22(15):3077-92.
    View in: PubMed
  3. Banigan MG, Kao PF, Kozubek JA, Winslow AR, Medina J, Costa J, Schmitt A, Schneider A, Cabral H, Cagsal-Getkin O, Vanderburg CR, Delalle I. Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients. PLoS One. 2013; 8(1):e48814.
    View in: PubMed
  4. Hu B, Jiang G, Pang C, Wang S, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Deng Y, Huang X. Assessment of gene order computing methods for Alzheimer's disease. BMC Med Genomics. 2013; 6 Suppl 1:S8.
    View in: PubMed
  5. Vanderburg CR, Clarke MS. Laser capture microdissection of metachromatically stained skeletal muscle allows quantification of fiber type specific gene expression. Mol Cell Biochem. 2013 Mar; 375(1-2):159-70.
    View in: PubMed
  6. Danzer KM, Kranich LR, Ruf WP, Cagsal-Getkin O, Winslow AR, Zhu L, Vanderburg CR, McLean PJ. Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol Neurodegener. 2012; 7:42.
    View in: PubMed
  7. Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol. 2012 Jul; 71(7):654-64.
    View in: PubMed
  8. Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E128-35.
    View in: PubMed
  9. Unni VK, Ebrahimi-Fakhari D, Vanderburg CR, McLean PJ, Hyman BT. Studying protein degradation pathways in vivo using a cranial window-based approach. Methods. 2011 Mar; 53(3):194-200.
    View in: PubMed
  10. Kao PF, Davis DA, Banigan MG, Vanderburg CR, Seshadri S, Delalle I. Modulators of cytoskeletal reorganization in CA1 hippocampal neurons show increased expression in patients at mid-stage Alzheimer's disease. PLoS One. 2010; 5(10):e13337.
    View in: PubMed
  11. Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT. Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. J Biol Chem. 2010 Oct 8; 285(41):31217-32.
    View in: PubMed
  12. Pang CY, Hu W, Hu BQ, Shi Y, Vanderburg CR, Rogers JT, Huang X. A special local clustering algorithm for identifying the genes associated with Alzheimer's disease. IEEE Trans Nanobioscience. 2010 Mar; 9(1):44-50.
    View in: PubMed
  13. Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009 Feb 27; 323(5918):1205-8.
    View in: PubMed
  14. Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X. Independent component analysis of Alzheimer's DNA microarray gene expression data. Mol Neurodegener. 2009; 4:5.
    View in: PubMed
  15. Ferland RJ, Batiz LF, Neal J, Lian G, Bundock E, Lu J, Hsiao YC, Diamond R, Mei D, Banham AH, Brown PJ, Vanderburg CR, Joseph J, Hecht JL, Folkerth R, Guerrini R, Walsh CA, Rodriguez EM, Sheen VL. Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia. Hum Mol Genet. 2009 Feb 1; 18(3):497-516.
    View in: PubMed
  16. Kong W, Vanderburg CR, Gunshin H, Rogers JT, Huang X. A review of independent component analysis application to microarray gene expression data. Biotechniques. 2008 Nov; 45(5):501-20.
    View in: PubMed
  17. Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, Standaert DG, Irizarry MC, Hyman BT. No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain. Acta Neuropathol. 2006 Oct; 112(4):439-49.
    View in: PubMed
  18. Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. J Struct Biol. 2006 Jul; 155(1):45-51.
    View in: PubMed
  19. Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT, Ingelsson M. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp Neurol. 2005 Jul; 194(1):91-6.
    View in: PubMed
  20. Carterson AJ, Höner zu Bentrup K, Ott CM, Clarke MS, Pierson DL, Vanderburg CR, Buchanan KL, Nickerson CA, Schurr MJ. A549 lung epithelial cells grown as three-dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis. Infect Immun. 2005 Feb; 73(2):1129-40.
    View in: PubMed
  21. Clarke MS, Vanderburg CR, Feeback DL. The effect of acute microgravity on mechanically-induced membrane damage and membrane-membrane fusion events. J Gravit Physiol. 2001 Dec; 8(2):37-47.
    View in: PubMed
  22. Nickerson CA, Goodwin TJ, Terlonge J, Ott CM, Buchanan KL, Uicker WC, Emami K, LeBlanc CL, Ramamurthy R, Clarke MS, Vanderburg CR, Hammond T, Pierson DL. Three-dimensional tissue assemblies: novel models for the study of Salmonella enterica serovar Typhimurium pathogenesis. Infect Immun. 2001 Nov; 69(11):7106-20.
    View in: PubMed
  23. Clarke MS, Vanderburg CR, Bamman MM, Caldwell RW, Feeback DL. In situ localization of cholesterol in skeletal muscle by use of a monoclonal antibody. J Appl Physiol. 2000 Aug; 89(2):731-41.
    View in: PubMed
  24. Sun D, Vanderburg CR, Odierna GS, Hay ED. TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro. Development. 1998 Jan; 125(1):95-105.
    View in: PubMed
  25. Vanderburg CR, Hay ED. E-cadherin transforms embryonic corneal fibroblasts to stratified epithelium with desmosomes. Acta Anat (Basel). 1996; 157(2):87-104.
    View in: PubMed
  26. Clarke MS, Vanderburg CR, Hay ED, McNeil PL. Cytoplasmic loading of dyes, protein and plasmid DNA using an impact-mediated procedure. Biotechniques. 1994 Dec; 17(6):1118-25.
    View in: PubMed
  27. Vanderburg CR, Nathanson MA. Posttranscriptional control of embryonic rat skeletal muscle protein synthesis. Control at the level of translation by endogenous RNA. J Cell Biol. 1988 Sep; 107(3):1085-98.
    View in: PubMed
  28. Nathanson MA, Bush EW, Vanderburg C. Transcriptional-translational regulation of muscle-specific protein synthesis and its relationship to chondrogenic stimuli. J Biol Chem. 1986 Jan 25; 261(3):1477-86.
    View in: PubMed
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