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Keywords
Last Name
Institution

Tomas Leopold Kirchhausen, Ph.D.

TitleProfessor of Cell Biology
InstitutionImmune Disease Institute
DepartmentCell Biology
AddressImmune Disease Institute
PCMM, Warren Alpert Building, Rm 133B
200 Longwood Ave
Boston MA 02115
Phone617/713-8888
Fax617/713-8898
Other Positions
TitleDirector of the HMS-Portugal Program
InstitutionHarvard Medical School
DepartmentOperations and Business Affairs

TitleProfessor of Pediatrics
InstitutionImmune Disease Institute
DepartmentPediatrics


 Mentoring 
 completed student projects
Secramine: Specificity and Inhibition of Cell Transformation
Summer, 06/27/05 - 08/19/05

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Boulant S, Stanifer M, Kural C, Cureton DK, Massol R, Nibert ML, Kirchhausen T. Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Apr; 24(8):1196-207.
    View in: PubMed
  2. Kural C, Tacheva-Grigorova SK, Boulant S, Cocucci E, Baust T, Duarte D, Kirchhausen T. Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers. Cell Rep. 2012 Nov 29; 2(5):1111-9.
    View in: PubMed
  3. Kirchhausen T. Bending membranes. Nat Cell Biol. 2012 Sep; 14(9):906-8.
    View in: PubMed
  4. Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3; 11(2):242-52.
    View in: PubMed
  5. Cocucci E, Aguet F, Boulant S, Kirchhausen T. The first five seconds in the life of a clathrin-coated pit. Cell. 2012 Aug 3; 150(3):495-507.
    View in: PubMed
  6. Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S. Regulation of ligand-independent Notch signal through intracellular trafficking. Commun Integr Biol. 2012 Jul 1; 5(4):374-6.
    View in: PubMed
  7. Cureton DK, Harbison CE, Cocucci E, Parrish CR, Kirchhausen T. Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures. J Virol. 2012 May; 86(9):5330-40.
    View in: PubMed
  8. Strang BL, Boulant S, Kirchhausen T, Coen DM. Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. MBio. 2012; 3(1).
    View in: PubMed
  9. Kural C, Kirchhausen T. Live-cell imaging of clathrin coats. Methods Enzymol. 2012; 505:59-80.
    View in: PubMed
  10. Lu L, Kirchhausen T. Visualizing the high curvature regions of post-mitotic nascent nuclear envelope membrane. Commun Integr Biol. 2012 Jan 1; 5(1):16-8.
    View in: PubMed
  11. Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011 Dec 12; 195(6):1005-15.
    View in: PubMed
  12. Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95.
    View in: PubMed
  13. Boulant S, Kural C, Zeeh JC, Ubelmann F, Kirchhausen T. Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. Nat Cell Biol. 2011 Sep; 13(9):1124-31.
    View in: PubMed
  14. Lu L, Ladinsky MS, Kirchhausen T. Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly. J Cell Biol. 2011 Aug 8; 194(3):425-40.
    View in: PubMed
  15. Ivanovic T, Boulant S, Ehrlich M, Demidenko AA, Arnold MM, Kirchhausen T, Nibert ML. Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking. Traffic. 2011 Sep; 12(9):1179-95.
    View in: PubMed
  16. Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011 Aug; 12(8):770-7.
    View in: PubMed
  17. Boucrot E, Howes MT, Kirchhausen T, Parton RG. Redistribution of caveolae during mitosis. J Cell Sci. 2011 Jun 15; 124(Pt 12):1965-72.
    View in: PubMed
  18. Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, Li J, Beznoussenko GV, Nie Z, Luo R, Fu L, Collawn JF, Kirchhausen T, Luini A, Hsu VW. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011 May; 13(5):559-67.
    View in: PubMed
  19. Böcking T, Aguet F, Harrison SC, Kirchhausen T. Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating. Nat Struct Mol Biol. 2011 Mar; 18(3):295-301.
    View in: PubMed
  20. Yu A, Xing Y, Harrison SC, Kirchhausen T. Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13; 18(10):1311-20.
    View in: PubMed
  21. Cureton DK, Massol RH, Whelan SP, Kirchhausen T. The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis. PLoS Pathog. 2010; 6(9):e1001127.
    View in: PubMed
  22. Guan R, Dai H, Han D, Harrison SC, Kirchhausen T. Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding. Structure. 2010 Sep 8; 18(9):1191-8.
    View in: PubMed
  23. Harrison SC, Kirchhausen T. Structural biology: Conservation in vesicle coats. Nature. 2010 Aug 26; 466(7310):1048-9.
    View in: PubMed
  24. Utskarpen A, Massol R, van Deurs B, Lauvrak SU, Kirchhausen T, Sandvig K. Shiga toxin increases formation of clathrin-coated pits through Syk kinase. PLoS One. 2010; 5(7):e10944.
    View in: PubMed
  25. Boucrot E, Saffarian S, Zhang R, Kirchhausen T. Roles of AP-2 in clathrin-mediated endocytosis. PLoS One. 2010; 5(5):e10597.
    View in: PubMed
  26. Anitei M, Stange C, Parshina I, Baust T, Schenck A, Raposo G, Kirchhausen T, Hoflack B. Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. Nat Cell Biol. 2010 Apr; 12(4):330-40.
    View in: PubMed
  27. Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafé L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010 Jan 21; 362(3):206-16.
    View in: PubMed
  28. Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood. 2010 Feb 25; 115(8):1582-93.
    View in: PubMed
  29. Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC. Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 3; 29(3):655-65.
    View in: PubMed
  30. Kirchhausen T. Imaging endocytic clathrin structures in living cells. Trends Cell Biol. 2009 Nov; 19(11):596-605.
    View in: PubMed
  31. Saffarian S, Cocucci E, Kirchhausen T. Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol. 2009 Sep; 7(9):e1000191.
    View in: PubMed
  32. Lu L, Ladinsky MS, Kirchhausen T. Cisternal organization of the endoplasmic reticulum during mitosis. Mol Biol Cell. 2009 Aug; 20(15):3471-80.
    View in: PubMed
  33. Cureton DK, Massol RH, Saffarian S, Kirchhausen TL, Whelan SP. Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog. 2009 Apr; 5(4):e1000394.
    View in: PubMed
  34. Shulman Z, Shinder V, Klein E, Grabovsky V, Yeger O, Geron E, Montresor A, Bolomini-Vittori M, Feigelson SW, Kirchhausen T, Laudanna C, Shakhar G, Alon R. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity. 2009 Mar 20; 30(3):384-96.
    View in: PubMed
  35. Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, Hirsch E, Inghirami G, Chiarle R. The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer Res. 2008 Nov 1; 68(21):8899-907.
    View in: PubMed
  36. Boucrot E, Kirchhausen T. Mammalian cells change volume during mitosis. PLoS One. 2008; 3(1):e1477.
    View in: PubMed
  37. Kirchhausen T, Macia E, Pelish HE. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol. 2008; 438:77-93.
    View in: PubMed
  38. Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8; 47(1):460-72.
    View in: PubMed
  39. Veiga E, Guttman JA, Bonazzi M, Boucrot E, Toledo-Arana A, Lin AE, Enninga J, Pizarro-Cerdá J, Finlay BB, Kirchhausen T, Cossart P. Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. Cell Host Microbe. 2007 Nov 15; 2(5):340-51.
    View in: PubMed
  40. Saffarian S, Kirchhausen T. Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane. Biophys J. 2008 Mar 15; 94(6):2333-42.
    View in: PubMed
  41. Rapoport I, Boll W, Yu A, Böcking T, Kirchhausen T. A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction. Mol Biol Cell. 2008 Jan; 19(1):405-13.
    View in: PubMed
  42. Jiang S, Zhou X, Kirchhausen T, Wong ST. Tracking molecular particles in live cells using fuzzy rule-based system. Cytometry A. 2007 Aug; 71(8):576-84.
    View in: PubMed
  43. Jiang S, Zhou X, Kirchhausen T, Wong ST. Detection of molecular particles in live cells via machine learning. Cytometry A. 2007 Aug; 71(8):563-75.
    View in: PubMed
  44. Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30; 178(3):453-64.
    View in: PubMed
  45. Kirchhausen T. Making COPII coats. Cell. 2007 Jun 29; 129(7):1251-2.
    View in: PubMed
  46. Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL. PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell. 2007 Jul; 18(7):2646-55.
    View in: PubMed
  47. Boucrot E, Kirchhausen T. Endosomal recycling controls plasma membrane area during mitosis. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):7939-44.
    View in: PubMed
  48. Ma YM, Boucrot E, Villén J, Affar el B, Gygi SP, Göttlinger HG, Kirchhausen T. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. J Biol Chem. 2007 Mar 30; 282(13):9805-12.
    View in: PubMed
  49. Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T. Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell. 2007 Jan; 12(1):129-41.
    View in: PubMed
  50. Xu B, Pelish H, Kirchhausen T, Hammond GB. Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Org Biomol Chem. 2006 Nov 21; 4(22):4149-57.
    View in: PubMed
  51. Newton AJ, Kirchhausen T, Murthy VN. Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17955-60.
    View in: PubMed
  52. Falcone S, Cocucci E, Podini P, Kirchhausen T, Clementi E, Meldolesi J. Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events. J Cell Sci. 2006 Nov 15; 119(Pt 22):4758-69.
    View in: PubMed
  53. Cheng Y, Boll W, Kirchhausen T, Harrison SC, Walz T. Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol. 2007 Jan 19; 365(3):892-9.
    View in: PubMed
  54. Boucrot E, Saffarian S, Massol R, Kirchhausen T, Ehrlich M. Role of lipids and actin in the formation of clathrin-coated pits. Exp Cell Res. 2006 Dec 10; 312(20):4036-48.
    View in: PubMed
  55. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60.
    View in: PubMed
  56. Massol RH, Boll W, Griffin AM, Kirchhausen T. A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10265-70.
    View in: PubMed
  57. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun; 10(6):839-50.
    View in: PubMed
  58. Goess BC, Hannoush RN, Chan LK, Kirchhausen T, Shair MD. Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors. J Am Chem Soc. 2006 Apr 26; 128(16):5391-403.
    View in: PubMed
  59. Pelish HE, Ciesla W, Tanaka N, Reddy K, Shair MD, Kirchhausen T, Lencer WI. The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells. Biochem Pharmacol. 2006 Jun 14; 71(12):1720-6.
    View in: PubMed
  60. Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol. 2006 Jan; 2(1):39-46.
    View in: PubMed
  61. Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity. 2005 Sep; 23(3):249-62.
    View in: PubMed
  62. McNeil PL, Kirchhausen T. An emergency response team for membrane repair. Nat Rev Mol Cell Biol. 2005 Jun; 6(6):499-505.
    View in: PubMed
  63. Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M. The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem. 2005 Jun 3; 280(22):21661-6.
    View in: PubMed
  64. Massol RH, Larsen JE, Kirchhausen T. Possible role of deep tubular invaginations of the plasma membrane in MHC-I trafficking. Exp Cell Res. 2005 May 15; 306(1):142-9.
    View in: PubMed
  65. Nieland TJ, Ehrlich M, Krieger M, Kirchhausen T. Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI. Biochim Biophys Acta. 2005 May 1; 1734(1):44-51.
    View in: PubMed
  66. Kirchhausen T, Boll W, van Oijen A, Ehrlich M. Single-molecule live-cell imaging of clathrin-based endocytosis. Biochem Soc Symp. 2005; (72):71-6.
    View in: PubMed
  67. Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem. 2005 Jan 28; 280(4):2818-25.
    View in: PubMed
  68. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 2; 432(7017):573-9.
    View in: PubMed
  69. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 2; 432(7017):649-53.
    View in: PubMed
  70. Heldwein EE, Macia E, Wang J, Yin HL, Kirchhausen T, Harrison SC. Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14108-13.
    View in: PubMed
  71. Ehrlich M, Boll W, Van Oijen A, Hariharan R, Chandran K, Nibert ML, Kirchhausen T. Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell. 2004 Sep 3; 118(5):591-605.
    View in: PubMed
  72. Cerny J, Feng Y, Yu A, Miyake K, Borgonovo B, Klumperman J, Meldolesi J, McNeil PL, Kirchhausen T. The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004 Sep; 5(9):883-8.
    View in: PubMed
  73. Boll W, Ehrlich M, Collier RJ, Kirchhausen T. Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol. 2004 Jul; 83(6):281-8.
    View in: PubMed
  74. Nieland TJ, Feng Y, Brown JX, Chuang TD, Buckett PD, Wang J, Xie XS, McGraw TE, Kirchhausen T, Wessling-Resnick M. Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic. Traffic. 2004 Jul; 5(7):478-92.
    View in: PubMed
  75. Feng Y, Jadhav AP, Rodighiero C, Fujinaga Y, Kirchhausen T, Lencer WI. Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 2004 Jun; 5(6):596-601.
    View in: PubMed
  76. Massol RH, Larsen JE, Fujinaga Y, Lencer WI, Kirchhausen T. Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell. 2004 Aug; 15(8):3631-41.
    View in: PubMed
  77. Nieland TJ, Chroni A, Fitzgerald ML, Maliga Z, Zannis VI, Kirchhausen T, Krieger M. Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004 Jul; 45(7):1256-65.
    View in: PubMed
  78. Chandran K, Parker JS, Ehrlich M, Kirchhausen T, Nibert ML. The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry. J Virol. 2003 Dec; 77(24):13361-75.
    View in: PubMed
  79. Larsen JE, Massol RH, Nieland TJ, Kirchhausen T. HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity. Mol Biol Cell. 2004 Jan; 15(1):323-31.
    View in: PubMed
  80. Boes M, Bertho N, Cerny J, Op den Brouw M, Kirchhausen T, Ploegh H. T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner. J Immunol. 2003 Oct 15; 171(8):4081-8.
    View in: PubMed
  81. Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL. Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell. 2003 Aug 8; 114(3):299-310.
    View in: PubMed
  82. Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ. Phenotypic screening of small molecule libraries by high throughput cell imaging. Comb Chem High Throughput Screen. 2003 Jun; 6(4):279-86.
    View in: PubMed
  83. Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6469-74.
    View in: PubMed
  84. Legesse-Miller A, Massol RH, Kirchhausen T. Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. Mol Biol Cell. 2003 May; 14(5):1953-63.
    View in: PubMed
  85. Nieland TJ, Penman M, Dori L, Krieger M, Kirchhausen T. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15422-7.
    View in: PubMed
  86. Boes M, Cerny J, Massol R, Op den Brouw M, Kirchhausen T, Chen J, Ploegh HL. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature. 2002 Aug 29; 418(6901):983-8.
    View in: PubMed
  87. Boll W, Rapoport I, Brunner C, Modis Y, Prehn S, Kirchhausen T. The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites. Traffic. 2002 Aug; 3(8):590-600.
    View in: PubMed
  88. Schaefer AW, Kamei Y, Kamiguchi H, Wong EV, Rapoport I, Kirchhausen T, Beach CM, Landreth G, Lemmon SK, Lemmon V. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J Cell Biol. 2002 Jun 24; 157(7):1223-32.
    View in: PubMed
  89. Kirchhausen T. Clathrin adaptors really adapt. Cell. 2002 May 17; 109(4):413-6.
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  90. Kirchhausen T. Single-handed recognition of a sorting traffic motif by the GGA proteins. Nat Struct Biol. 2002 Apr; 9(4):241-4.
    View in: PubMed
  91. Lederkremer GZ, Cheng Y, Petre BM, Vogan E, Springer S, Schekman R, Walz T, Kirchhausen T. Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10704-9.
    View in: PubMed
  92. Pelish HE, Westwood NJ, Feng Y, Kirchhausen T, Shair MD. Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product. J Am Chem Soc. 2001 Jul 11; 123(27):6740-1.
    View in: PubMed
  93. Kirchhausen T. Three ways to make a vesicle. Nat Rev Mol Cell Biol. 2000 Dec; 1(3):187-98.
    View in: PubMed
  94. Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol. 2000 Jun 29; 10(13):758-65.
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  95. Farr GW, Furtak K, Rowland MB, Ranson NA, Saibil HR, Kirchhausen T, Horwich AL. Multivalent binding of nonnative substrate proteins by the chaperonin GroEL. Cell. 2000 Mar 3; 100(5):561-73.
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  96. ter Haar E, Harrison SC, Kirchhausen T. Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin. Proc Natl Acad Sci U S A. 2000 Feb 1; 97(3):1096-100.
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  97. Kirchhausen T. Clathrin. Annu Rev Biochem. 2000; 69:699-727.
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  98. Jones AT, Spiro DJ, Kirchhausen T, Melançon P, Wessling-Resnick M. Studies on the inhibition of endosome fusion by GTPgammaS-bound ARF. J Cell Sci. 1999 Oct; 112 ( Pt 20):3477-85.
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  99. Schneider H, Martin M, Agarraberes FA, Yin L, Rapoport I, Kirchhausen T, Rudd CE. Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol. 1999 Aug 15; 163(4):1868-79.
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  100. Musacchio A, Smith CJ, Roseman AM, Harrison SC, Kirchhausen T, Pearse BM. Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography. Mol Cell. 1999 Jun; 3(6):761-70.
    View in: PubMed
  101. Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 1999 Apr 16; 97(2):221-31.
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  102. Kirchhausen T. Cell biology. Boa constrictor or rattlesnake? Nature. 1999 Apr 8; 398(6727):470-1.
    View in: PubMed
  103. Kirchhausen T. Adaptors for clathrin-mediated traffic. Annu Rev Cell Dev Biol. 1999; 15:705-32.
    View in: PubMed
  104. ter Haar E, Musacchio A, Harrison SC, Kirchhausen T. Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. Cell. 1998 Nov 13; 95(4):563-73.
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  105. Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol. 1998 Nov 5; 8(22):1239-42.
    View in: PubMed
  106. Kirchhausen T. Vesicle formation: dynamic dynamin lives up to its name. Curr Biol. 1998 Nov 5; 8(22):R792-4.
    View in: PubMed
  107. Sanderfoot AA, Ahmed SU, Marty-Mazars D, Rapoport I, Kirchhausen T, Marty F, Raikhel NV. A putative vacuolar cargo receptor partially colocalizes with AtPEP12p on a prevacuolar compartment in Arabidopsis roots. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9920-5.
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  108. DeTulleo L, Kirchhausen T. The clathrin endocytic pathway in viral infection. EMBO J. 1998 Aug 17; 17(16):4585-93.
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  109. Kamiguchi H, Long KE, Pendergast M, Schaefer AW, Rapoport I, Kirchhausen T, Lemmon V. The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway. J Neurosci. 1998 Jul 15; 18(14):5311-21.
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  110. Kirchhausen T. Wiskott-Aldrich syndrome: a gene, a multifunctional protein and the beginnings of an explanation. Mol Med Today. 1998 Jul; 4(7):300-4.
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  111. Rapoport I, Chen YC, Cupers P, Shoelson SE, Kirchhausen T. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J. 1998 Apr 15; 17(8):2148-55.
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  112. Cupers P, Jadhav AP, Kirchhausen T. Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors. J Biol Chem. 1998 Jan 23; 273(4):1847-50.
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  113. Tong X, Boll W, Kirchhausen T, Howley PM. Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1. J Virol. 1998 Jan; 72(1):476-82.
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  114. Cupers P, ter Haar E, Boll W, Kirchhausen T. Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15. J Biol Chem. 1997 Dec 26; 272(52):33430-4.
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  115. Kirchhausen T, Bonifacino JS, Riezman H. Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr Opin Cell Biol. 1997 Aug; 9(4):488-95.
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  116. Kirchhausen T, Pines J, Toldo L, Lafont F. Membranes and sorting. Membrane permeability. Curr Opin Cell Biol. 1997 Jul 1; 9(4):473.
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  117. Clairmont KB, Boll W, Ericsson M, Kirchhausen T. A role for the hinge/ear domain of the beta chains in the incorporation of AP complexes into clathrin-coated pits and coated vesicles. Cell Mol Life Sci. 1997 Jul; 53(7):611-9.
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  118. Rapoport I, Miyazaki M, Boll W, Duckworth B, Cantley LC, Shoelson S, Kirchhausen T. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J. 1997 May 1; 16(9):2240-50.
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  119. Tebar F, Sorkina T, Sorkin A, Ericsson M, Kirchhausen T. Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. J Biol Chem. 1996 Nov 15; 271(46):28727-30.
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  120. Boll W, Ohno H, Songyang Z, Rapoport I, Cantley LC, Bonifacino JS, Kirchhausen T. Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J. 1996 Nov 1; 15(21):5789-95.
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  121. Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ. Identification of Itk/Tsk Src homology 3 domain ligands. J Biol Chem. 1996 Oct 11; 271(41):25646-56.
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  122. Bonifacino JS, Marks MS, Ohno H, Kirchhausen T. Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways. Proc Assoc Am Physicians. 1996 Jul; 108(4):285-95.
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  123. Kirchhausen T, Rosen FS. Disease mechanism: unravelling Wiskott-Aldrich syndrome. Curr Biol. 1996 Jun 1; 6(6):676-8.
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  124. Kolluri R, Tolias KF, Carpenter CL, Rosen FS, Kirchhausen T. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5615-8.
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  125. Spiro DJ, Boll W, Kirchhausen T, Wessling-Resnick M. Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro. Mol Biol Cell. 1996 Mar; 7(3):355-67.
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  126. Shih W, Gallusser A, Kirchhausen T. A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes. J Biol Chem. 1995 Dec 29; 270(52):31083-90.
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  127. Boll W, Gallusser A, Kirchhausen T. Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2. Curr Biol. 1995 Oct 1; 5(10):1168-78.
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  128. Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS. Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science. 1995 Sep 29; 269(5232):1872-5.
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  129. Rad MR, Phan HL, Kirchrath L, Tan PK, Kirchhausen T, Hollenberg CP, Payne GS. Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. J Cell Sci. 1995 Apr; 108 ( Pt 4):1605-15.
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  130. Speelman BA, Allen K, Grounds TL, Neutra MR, Kirchhausen T, Wilson JM. Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells. J Biol Chem. 1995 Jan 27; 270(4):1583-8.
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  131. Sorkin A, McKinsey T, Shih W, Kirchhausen T, Carpenter G. Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2. J Biol Chem. 1995 Jan 13; 270(2):619-25.
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  132. Stepp JD, Pellicena-Palle A, Hamilton S, Kirchhausen T, Lemmon SK. A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein. Mol Biol Cell. 1995 Jan; 6(1):41-58.
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  133. Søgaard M, Tani K, Ye RR, Geromanos S, Tempst P, Kirchhausen T, Rothman JE, Söllner T. A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell. 1994 Sep 23; 78(6):937-48.
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  134. Phan HL, Finlay JA, Chu DS, Tan PK, Kirchhausen T, Payne GS. The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex. EMBO J. 1994 Apr 1; 13(7):1706-17.
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  135. Osborn L, Vassallo C, Browning BG, Tizard R, Haskard DO, Benjamin CD, Dougas I, Kirchhausen T. Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1). J Cell Biol. 1994 Feb; 124(4):601-8.
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  136. Gallusser A, Kirchhausen T. The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. EMBO J. 1993 Dec 15; 12(13):5237-44.
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  137. Kirchhausen T, Toyoda T. Immunoelectron microscopic evidence for the extended conformation of light chains in clathrin trimers. J Biol Chem. 1993 May 15; 268(14):10268-73.
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  138. Kirchhausen T, Staunton DE, Springer TA. Location of the domains of ICAM-1 by immunolabeling and single-molecule electron microscopy. J Leukoc Biol. 1993 Mar; 53(3):342-6.
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  139. Nakayama Y, Goebl M, O'Brine Greco B, Lemmon S, Pingchang Chow E, Kirchhausen T. The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem. 1991 Dec 5; 202(2):569-74.
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  140. Kirchhausen T, Davis AC, Frucht S, Greco BO, Payne GS, Tubb B. AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991 Jun 15; 266(17):11153-7.
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  141. Keen JH, Beck KA, Kirchhausen T, Jarrett T. Clathrin domains involved in recognition by assembly protein AP-2. J Biol Chem. 1991 Apr 25; 266(12):7950-6.
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  142. Matsui W, Kirchhausen T. Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2. Biochemistry. 1990 Dec 4; 29(48):10791-8.
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  143. Kirchhausen T. Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes. Mol Cell Biol. 1990 Nov; 10(11):6089-90.
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  144. Tucker KL, Nathanson K, Kirchhausen T. Sequence of the rat alpha c large chain of the clathrin associated protein complex AP-2. Nucleic Acids Res. 1990 Sep 11; 18(17):5306.
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  145. Scarmato P, Kirchhausen T. Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3. J Biol Chem. 1990 Mar 5; 265(7):3661-8.
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  146. Kirchhausen T, Nathanson KL, Matsui W, Vaisberg A, Chow EP, Burne C, Keen JH, Davis AE. Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2612-6.
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  147. Thurieau C, Brosius J, Burne C, Jolles P, Keen JH, Mattaliano RJ, Chow EP, Ramachandran KL, Kirchhausen T. Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles. DNA. 1988 Dec; 7(10):663-9.
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  148. Kirchhausen T, Harrison SC, Chow EP, Mattaliano RJ, Ramachandran KL, Smart J, Brosius J. Clathrin heavy chain: molecular cloning and complete primary structure. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):8805-9.
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  149. Kirchhausen T, Scarmato P, Harrison SC, Monroe JJ, Chow EP, Mattaliano RJ, Ramachandran KL, Smart JE, Ahn AH, Brosius J. Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. Science. 1987 Apr 17; 236(4799):320-4.
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  150. Kirchhausen T, Harrison SC, Heuser J. Configuration of clathrin trimers: evidence from electron microscopy. J Ultrastruct Mol Struct Res. 1986 Mar; 94(3):199-208.
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  151. Kirchhausen T, Wang JC, Harrison SC. DNA gyrase and its complexes with DNA: direct observation by electron microscopy. Cell. 1985 Jul; 41(3):933-43.
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  152. Heuser J, Kirchhausen T. Deep-etch views of clathrin assemblies. J Ultrastruct Res. 1985 Jul-Aug; 92(1-2):1-27.
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  153. Kirchhausen T, Harrison SC. Structural domains of clathrin heavy chains. J Cell Biol. 1984 Nov; 99(5):1725-34.
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  154. Hogle J, Kirchhausen T, Harrison SC. Divalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution. J Mol Biol. 1983 Nov 25; 171(1):95-100.
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  155. Harrison SC, Kirchhausen T. Clathrin, cages, and coated vesicles. Cell. 1983 Jul; 33(3):650-2.
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  156. Kirchhausen T, Harrison SC, Parham P, Brodsky FM. Location and distribution of the light chains in clathrin trimers. Proc Natl Acad Sci U S A. 1983 May; 80(9):2481-5.
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  157. León V, Kirchhausen T, Avila EM, Mateu L. Thermal effects in human plasma high density lipoproteins (HDL)3: a 13C-FT-NMR study. Acta Cient Venez. 1983; 34(3-4):209-15.
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  158. Fless GM, Kirchhausen T, Fischer-Dzoga K, Wissler RW, Scanu AM. Serum low density lipoproteins with mitogenic effect on cultured aortic smooth muscle cells. Atherosclerosis. 1982 Feb; 41(2-3):171-83.
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  159. Kirchhausen T, Harrison SC. Protein organization in clathrin trimers. Cell. 1981 Mar; 23(3):755-61.
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  160. Kirchhausen T, Fless G, Scanu AM. The structure of plasma low density lipoproteins: experimental facts and interpretations--a minireview. Lipids. 1980 Jun; 15(6):464-7.
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  161. Kirchhausen T, Untracht SH, Fless GM, Scanu AM. Atherogenic diets and neutral-lipid organization in plasma low density lipoproteins. Atherosclerosis. 1979 May; 33(1):59-70.
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  162. Mateu L, Kirchhausen T. Kinetics of thermal transitions in human serum low density lipoproteins (LDL) and neutral lipids. A dynamic small-angle X-ray scattering study. Acta Cient Venez. 1979; 30(5):478-83.
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  163. Mateu L, Kirchhausen T, Camejo G. Small-angle X-ray scattering and differential scanning calorimetry studies on reversibly modified human-serum low density lipoproteins. Biochemistry. 1978 Apr 18; 17(8):1436-40.
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  164. Mateu L, Kirchhausen T, Camejo G. A low temperature structural transition in human serum low density lipoproteins. Biochim Biophys Acta. 1977 Apr 26; 487(1):243-5.
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  165. Mateu L, Kirchhausen T, Padrón R, Camejo G. Small-angle x-ray scattering study of human serum low-density lipoproteins with differential reactivity for an arterial proteoglycan. J Supramol Struct. 1977; 7(3-4):435-42.
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