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Michael Scott Caplan, M.D.

TitleClinical Instructor in Psychiatry
InstitutionBeth Israel Deaconess Medical Center
DepartmentPsychiatry
Address1180 Beacon St
Suite 5C
1180 Beacon Street
Brookline MA 02446
Phone617/667-4738

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Soliman A, Michelsen KS, Karahashi H, Lu J, Meng FJ, Qu X, Crother TR, Rabizadeh S, Chen S, Caplan MS, Arditi M, Jilling T. Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. PLoS One. 2010; 5(10):e15044.
    View in: PubMed
  2. Alves DS, Farr GA, Seo-Mayer P, Caplan MJ. AS160 associates with the Na+,K+-ATPase and mediates the adenosine monophosphate-stimulated protein kinase-dependent regulation of sodium pump surface expression. Mol Biol Cell. 2010 Dec; 21(24):4400-8.
    View in: PubMed
  3. Lu J, Pierce M, Franklin A, Jilling T, Stafforini DM, Caplan M. Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr Res. 2010 Sep; 68(3):225-30.
    View in: PubMed
  4. Morowitz MJ, Poroyko V, Caplan M, Alverdy J, Liu DC. Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis. Pediatrics. 2010 Apr; 125(4):777-85.
    View in: PubMed
  5. Carmosino M, Valenti G, Caplan M, Svelto M. Polarized traffic towards the cell surface: how to find the route. Biol Cell. 2010 Feb; 102(2):75-91.
    View in: PubMed
  6. Farr GA, Hull M, Mellman I, Caplan MJ. Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. J Cell Biol. 2009 Jul 27; 186(2):269-82.
    View in: PubMed
  7. Caplan MS. Probiotic and prebiotic supplementation for the prevention of neonatal necrotizing enterocolitis. J Perinatol. 2009 May; 29 Suppl 2:S2-6.
    View in: PubMed
  8. Frost BL, Jilling T, Caplan MS. The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):100-6.
    View in: PubMed
  9. Caplan MS. Neonatal necrotizing enterocolitis. Introduction. Semin Perinatol. 2008 Apr; 32(2):69.
    View in: PubMed
  10. Lu J, Caplan MS, Li D, Jilling T. Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1181-90.
    View in: PubMed
  11. De Plaen IG, Liu SX, Tian R, Neequaye I, May MJ, Han XB, Hsueh W, Jilling T, Lu J, Caplan MS. Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis. Pediatr Res. 2007 Jun; 61(6):716-21.
    View in: PubMed
  12. Lu J, Jilling T, Li D, Caplan MS. Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Pediatr Res. 2007 Apr; 61(4):427-32.
    View in: PubMed
  13. Jilling T, Simon D, Lu J, Meng FJ, Li D, Schy R, Thomson RB, Soliman A, Arditi M, Caplan MS. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol. 2006 Sep 1; 177(5):3273-82.
    View in: PubMed
  14. Caplan MS, Simon D, Jilling T. The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. Semin Pediatr Surg. 2005 Aug; 14(3):145-51.
    View in: PubMed
  15. Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, Hammerman C. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr. 2005 Aug; 147(2):192-6.
    View in: PubMed
  16. Qu XW, Thaete LG, Rozenfeld RA, Zhu Y, De Plaen IG, Caplan MS, Hsueh W. Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. Crit Care Med. 2005 May; 33(5):1050-6.
    View in: PubMed
  17. Jilling T, Lu J, Jackson M, Caplan MS. Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis. Pediatr Res. 2004 Apr; 55(4):622-9.
    View in: PubMed
  18. Amer MD, Hedlund E, Rochester J, Caplan MS. Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. Biol Neonate. 2004; 85(3):159-66.
    View in: PubMed
  19. Lu J, Caplan MS, Saraf AP, Li D, Adler L, Liu X, Jilling T. Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G340-50.
    View in: PubMed
  20. Thaete LG, Neerhof MG, Jilling T, Caplan MS. Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. J Soc Gynecol Investig. 2003 Apr; 10(3):145-50.
    View in: PubMed
  21. Hsueh W, Caplan MS, Qu XW, Tan XD, De Plaen IG, Gonzalez-Crussi F. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatr Dev Pathol. 2003 Jan-Feb; 6(1):6-23.
    View in: PubMed
  22. Claud EC, Li D, Xiao Y, Caplan MS, Jilling T. Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. Pediatr Res. 2002 Aug; 52(2):155-62.
    View in: PubMed
  23. Caplan MS, Amer M, Jilling T. The role of human milk in necrotizing enterocolitis. Adv Exp Med Biol. 2002; 503:83-90.
    View in: PubMed
  24. Caplan MS, Jilling T. The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis. Lipids. 2001 Sep; 36(9):1053-7.
    View in: PubMed
  25. Caplan MS, Russell T, Xiao Y, Amer M, Kaup S, Jilling T. Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. Pediatr Res. 2001 May; 49(5):647-52.
    View in: PubMed
  26. Caplan MS, Jilling T. New concepts in necrotizing enterocolitis. Curr Opin Pediatr. 2001 Apr; 13(2):111-5.
    View in: PubMed
  27. Tan XD, Chang H, Qu XW, Caplan M, Gonzalez-Crussi F, Hsueh W. Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. Br J Pharmacol. 2000 Apr; 129(7):1522-9.
    View in: PubMed
  28. Caplan MS, Jilling T. Neonatal necrotizing enterocolitis: possible role of probiotic supplementation. J Pediatr Gastroenterol Nutr. 2000; 30 Suppl 2:S18-22.
    View in: PubMed
  29. Caplan MS, Miller-Catchpole R, Kaup S, Russell T, Lickerman M, Amer M, Xiao Y, Thomson R. Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Gastroenterology. 1999 Sep; 117(3):577-83.
    View in: PubMed
  30. Li D, Cheng SX, Fisone G, Caplan MJ, Ohtomo Y, Aperia A. Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase. Am J Physiol. 1998 Dec; 275(6 Pt 2):F863-9.
    View in: PubMed
  31. Hsueh W, Caplan MS, Tan X, MacKendrick W, Gonzalez-Crussi F. Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. Pediatr Dev Pathol. 1998 Jan-Feb; 1(1):2-16.
    View in: PubMed
  32. Gu H, Caplan MJ, Rudnick G. Cloned catecholamine transporters expressed in polarized epithelial cells: sorting, drug sensitivity, and ion-coupling stoichiometry. Adv Pharmacol. 1998; 42:175-9.
    View in: PubMed
  33. Caplan MS, Lickerman M, Adler L, Dietsch GN, Yu A. The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis. Pediatr Res. 1997 Dec; 42(6):779-83.
    View in: PubMed
  34. Neerhof MG, Silver RK, Caplan MS, Thaete LG. Endothelin-1-induced placental and fetal growth restriction in the rat. J Matern Fetal Med. 1997 May-Jun; 6(3):125-8.
    View in: PubMed
  35. Caplan MS, Hedlund E, Adler L, Lickerman M, Hsueh W. The platelet-activating factor receptor antagonist WEB 2170 prevents neonatal necrotizing enterocolitis in rats. J Pediatr Gastroenterol Nutr. 1997 Mar; 24(3):296-301.
    View in: PubMed
  36. Thaete LG, Neerhof MG, Caplan MS. Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat. Am J Obstet Gynecol. 1997 Jan; 176(1 Pt 1):73-6.
    View in: PubMed
  37. Silver RK, Kupferminc MJ, Russell TL, Adler L, Mullen TA, Caplan MS. Evaluation of nitric oxide as a mediator of severe preeclampsia. Am J Obstet Gynecol. 1996 Oct; 175(4 Pt 1):1013-7.
    View in: PubMed
  38. Gu HH, Ahn J, Caplan MJ, Blakely RD, Levey AI, Rudnick G. Cell-specific sorting of biogenic amine transporters expressed in epithelial cells. J Biol Chem. 1996 Jul 26; 271(30):18100-6.
    View in: PubMed
  39. Qu X, Huang L, Burthart T, Crawford SE, Caplan MS, Hsueh W. Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. Prostaglandins. 1996 Apr; 51(4):249-62.
    View in: PubMed
  40. Silver RK, Mullen TA, Caplan MS, O'Connell PD, Ragin A. Inducible platelet adherence to human umbilical vein endothelium by anticardiolipin antibody-positive sera. Am J Obstet Gynecol. 1995 Sep; 173(3 Pt 1):702-7.
    View in: PubMed
  41. Sun XM, MacKendrick W, Tien J, Huang W, Caplan MS, Hsueh W. Endogenous bacterial toxins are required for the injurious action of platelet-activating factor in rats. Gastroenterology. 1995 Jul; 109(1):83-8.
    View in: PubMed
  42. Hageman JR, Caplan MS. An introduction to the structure and function of inflammatory mediators for clinicians. Clin Perinatol. 1995 Jun; 22(2):251-61.
    View in: PubMed
  43. Sun X, Caplan MS, Liu Y, Hsueh W. Endotoxin-resistant mice are protected from PAF-induced bowel injury and death. Role of TNF, complement activation, and endogenous PAF production. Dig Dis Sci. 1995 Mar; 40(3):495-502.
    View in: PubMed
  44. Quigley RL, Caplan MS, Perkins JA, Arentzon CE, Alexander JC, Kuehn BE, Hoff WJ, Wallock ME. Cardiopulmonary bypass with adequate flow and perfusion pressures prevents endotoxaemia and pathologic cytokine production. Perfusion. 1995; 10(1):27-31.
    View in: PubMed
  45. Caplan MS, Hedlund E, Adler L, Hsueh W. Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis. Pediatr Pathol. 1994 Nov-Dec; 14(6):1017-28.
    View in: PubMed
  46. Caplan MS, MacKendrick W. Inflammatory mediators and intestinal injury. Clin Perinatol. 1994 Jun; 21(2):235-46.
    View in: PubMed
  47. Simonson SG, Welty-Wolf K, Huang YT, Griebel JA, Caplan MS, Fracica PJ, Piantadosi CA. Altered mitochondrial redox responses in gram negative septic shock in primates. Circ Shock. 1994 May; 43(1):34-43.
    View in: PubMed
  48. Lee MJ, Silver RK, O'Connell PD, Caplan MS. Endothelial cell 1-acyl-platelet-activating factor synthesis in response to anticardiolipin antibody-positive serum fractions. Prostaglandins. 1994 Mar; 47(3):221-31.
    View in: PubMed
  49. Caplan MS, Hedlund E, Hill N, MacKendrick W. The role of endogenous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats. Gastroenterology. 1994 Feb; 106(2):346-52.
    View in: PubMed
  50. Sun X, Caplan MS, Hsueh W. Tumour necrosis factor and endotoxin synergistically activate intestinal phospholipase A2 in mice. Role of endogenous platelet activating factor and effect of exogenous platelet activating factor. Gut. 1994 Feb; 35(2):215-9.
    View in: PubMed
  51. Hsueh W, Caplan MS, Sun X, Tan X, MacKendrick W, Gonzalez-Crussi F. Platelet-activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis. Acta Paediatr Suppl. 1994; 396:11-7.
    View in: PubMed
  52. MacKendrick W, Caplan M. Necrotizing enterocolitis. New thoughts about pathogenesis and potential treatments. Pediatr Clin North Am. 1993 Oct; 40(5):1047-59.
    View in: PubMed
  53. MacKendrick W, Caplan M, Hsueh W. Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat. Pediatr Res. 1993 Aug; 34(2):222-8.
    View in: PubMed
  54. Caplan MS, MacKendrick W. Necrotizing enterocolitis: a review of pathogenetic mechanisms and implications for prevention. Pediatr Pathol. 1993 May-Jun; 13(3):357-69.
    View in: PubMed
  55. Caplan MS. PAF and surfactant preparations. Lancet. 1993 Apr 3; 341(8849):865-6.
    View in: PubMed
  56. Silver RK, O'Connell PD, Caplan MS. Acetylsalicylic acid inhibits anticardiolipin antibody-induced platelet-activating factor (PAF) synthesis. Prostaglandins. 1993 Feb; 45(2):143-51.
    View in: PubMed
  57. MacKendrick W, Hill N, Hsueh W, Caplan M. Increase in plasma platelet-activating factor levels in enterally fed preterm infants. Biol Neonate. 1993; 64(2-3):89-95.
    View in: PubMed
  58. Caplan MS, Adler L, Kelly A, Hsueh W. Hypoxia increases stimulus-induced PAF production and release from human umbilical vein endothelial cells. Biochim Biophys Acta. 1992 Oct 30; 1128(2-3):205-10.
    View in: PubMed
  59. Caplan MS, Kelly A, Hsueh W. Endotoxin and hypoxia-induced intestinal necrosis in rats: the role of platelet activating factor. Pediatr Res. 1992 May; 31(5):428-34.
    View in: PubMed
  60. Silver RK, Caplan MS, Kelly AM. Amniotic fluid platelet-activating factor (PAF) is elevated in patients with tocolytic failure and preterm delivery. Prostaglandins. 1992 Feb; 43(2):181-7.
    View in: PubMed
  61. Caplan MS, Sun XM, Hsueh W. Hypoxia, PAF, and necrotizing enterocolitis. Lipids. 1991 Dec; 26(12):1340-3.
    View in: PubMed
  62. Musemeche C, Caplan M, Hsueh W, Sun X, Kelly A. Experimental necrotizing enterocolitis: the role of polymorphonuclear neutrophils. J Pediatr Surg. 1991 Sep; 26(9):1047-9; discussion 1049-50.
    View in: PubMed
  63. Zhang C, Hsueh W, Caplan MS, Kelly A. Platelet activating factor-induced shock and intestinal necrosis in the rat: role of endogenous platelet-activating factor and effect of saline infusion. Crit Care Med. 1991 Aug; 19(8):1067-72.
    View in: PubMed
  64. Caplan MS, Hsueh W, Sun XM, Gidding SS, Hageman JR. Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1258-62.
    View in: PubMed
  65. Caplan MS, Sun XM, Hsueh W. Hypoxia causes ischemic bowel necrosis in rats: the role of platelet-activating factor (PAF-acether). Gastroenterology. 1990 Oct; 99(4):979-86.
    View in: PubMed
  66. Caplan MS, Hsueh W. Necrotizing enterocolitis: role of platelet activating factor, endotoxin, and tumor necrosis factor. J Pediatr. 1990 Jul; 117(1 Pt 2):S47-51.
    View in: PubMed
  67. Arditi M, Manogue KR, Caplan M, Yogev R. Cerebrospinal fluid cachectin/tumor necrosis factor-alpha and platelet-activating factor concentrations and severity of bacterial meningitis in children. J Infect Dis. 1990 Jul; 162(1):139-47.
    View in: PubMed
  68. Caplan M, Hsueh W, Kelly A, Donovan M. Serum PAF acetylhydrolase increases during neonatal maturation. Prostaglandins. 1990 Jun; 39(6):705-14.
    View in: PubMed
  69. Caplan MS, Sun XM, Hseuh W, Hageman JR. Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis. J Pediatr. 1990 Jun; 116(6):960-4.
    View in: PubMed
  70. Caplan MS, MacGregor SN. Perinatal management of congenital diaphragmatic hernia and anterior abdominal wall defects. Clin Perinatol. 1989 Dec; 16(4):917-38.
    View in: PubMed
  71. Caplan MS, Cohn RA, Langman CB, Conway JA, Shkolnik A, Brouillette RT. Favorable outcome of neonatal aortic thrombosis and renovascular hypertension. J Pediatr. 1989 Aug; 115(2):291-5.
    View in: PubMed
  72. Baron R, Neff L, Roy C, Boisvert A, Caplan M. Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast. Cell. 1986 Jul 18; 46(2):311-20.
    View in: PubMed
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