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Keywords
Last Name
Institution

David Andrew Sinclair, Ph.D.

TitleProfessor of Genetics
InstitutionHarvard Medical School
DepartmentGenetics
AddressHarvard Medical School
New Research Building, 9th Floor
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-3931
Fax617/432-6225

 Mentoring 
 current student opportunities
Available: 09/15/12, Expires: 09/30/13

The project will study novel hits from a new genetic screen of the human genome that has identified more than a dozen new genes that control cellular energetics and possibly aging.

 completed student projects
The Role of CD38, NAD Levels, and Sirtuins on Neuronal Cell Survival During Ischemia
Summer, 06/13/11 - 08/05/11

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science. 2013 Mar 8; 339(6124):1216-9.
    View in: PubMed
  2. Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, Zulewski H, Geier A, Cermak JM, Elliott P, Ellis JL, Westphal C, Knobel U, Eloranta JJ, Kerr-Conte J, Pattou F, Konrad D, Matter CM, Fontana A, Rogler G, Schlapbach R, Regairaz C, Carballido JM, Glaser B, McBurney MW, Pociot F, Sinclair DA, Donath MY. Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes. Cell Metab. 2013 Mar 5; 17(3):448-55.
    View in: PubMed
  3. Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. A High-Confidence Interaction Map Identifies SIRT1 as a Mediator of Acetylation of USP22 and the SAGA Coactivator Complex. Mol Cell Biol. 2013 Apr; 33(8):1487-502.
    View in: PubMed
  4. Sinclair D, Verdin E. The longevity of sirtuins. Cell Rep. 2012 Dec 27; 2(6):1473-4.
    View in: PubMed
  5. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Diabetes. 2013 Apr; 62(4):1084-93.
    View in: PubMed
  6. Rascón B, Hubbard BP, Sinclair DA, Amdam GV. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging (Albany NY). 2012 Jul; 4(7):499-508.
    View in: PubMed
  7. Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev. 2012 Jul; 92(3):1479-514.
    View in: PubMed
  8. Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP. Prolyl isomerase Pin1 regulates neuronal differentiation via ß-catenin. Mol Cell Biol. 2012 Aug; 32(15):2966-78.
    View in: PubMed
  9. Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012 May 2; 15(5):675-90.
    View in: PubMed
  10. North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res. 2012 Apr 13; 110(8):1097-108.
    View in: PubMed
  11. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
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  12. Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic Acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2012 Jan; 68(1):6-16.
    View in: PubMed
  13. Han J, Hubbard BP, Lee J, Montagna C, Lee HW, Sinclair DA, Suh Y. Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle. 2013 Jan 15; 12(2):263-70.
    View in: PubMed
  14. Ackerman N, Aharmim B, Auger M, Auty DJ, Barbeau PS, Barry K, Bartoszek L, Beauchamp E, Belov V, Benitez-Medina C, Breidenbach M, Burenkov A, Cleveland B, Conley R, Conti E, Cook J, Cook S, Coppens A, Counts I, Craddock W, Daniels T, Danilov MV, Davis CG, Davis J, deVoe R, Djurcic Z, Dobi A, Dolgolenko AG, Dolinski MJ, Donato K, Dunford M, Fairbank W, Farine J, Fierlinger P, Franco D, Freytag D, Giroux G, Gornea R, Graham K, Gratta G, Green MP, Hägemann C, Hall C, Hall K, Haller G, Hargrove C, Herbst R, Herrin S, Hodgson J, Hughes M, Johnson A, Karelin A, Kaufman LJ, Koffas T, Kuchenkov A, Kumar A, Kumar KS, Leonard DS, Leonard F, LePort F, Mackay D, MacLellan R, Marino M, Martin Y, Mong B, Díez MM, Morgan P, Müller AR, Neilson R, Nelson R, Odian A, O'Sullivan K, Ouellet C, Piepke A, Pocar A, Prescott CY, Pushkin K, Rivas A, Rollin E, Rowson PC, Russell JJ, Sabourov A, Sinclair D, Skarpaas K, Slutsky S, Stekhanov V, Strickland V, Swift M, Tosi D, Twelker K, Vogel P, Vuilleumier JL, Vuilleumier JM, Waite A, Waldman S, Walton T, Wamba K, Weber M, Wichoski U, Wodin J, Wright JD, Yang L, Yen YR, Zeldovich OY. Observation of two-neutrino double-beta decay in 136Xe with the EXO-200 detector. Phys Rev Lett. 2011 Nov 18; 107(21):212501.
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  15. Accili D, de Cabo R, Sinclair DA. An unSIRTain role in longevity. Nat Med. 2011; 17(11):1350-1.
    View in: PubMed
  16. Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta. 2012 Feb; 1822(2):185-95.
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  17. LePort F, Neilson R, Barbeau PS, Barry K, Bartoszek L, Counts I, Davis J, deVoe R, Dolinski MJ, Gratta G, Green M, Montero Díez M, Müller AR, O'Sullivan K, Rivas A, Twelker K, Aharmim B, Auger M, Belov V, Benitez-Medina C, Breidenbach M, Burenkov A, Cleveland B, Conley R, Cook J, Cook S, Craddock W, Daniels T, Dixit M, Dobi A, Donato K, Fairbank W, Farine J, Fierlinger P, Franco D, Giroux G, Gornea R, Graham K, Green C, Hägemann C, Hall C, Hall K, Hallman D, Hargrove C, Herrin S, Hughes M, Hodgson J, Juget F, Kaufman LJ, Karelin A, Ku J, Kuchenkov A, Kumar K, Leonard DS, Lutter G, Mackay D, MacLellan R, Marino M, Mong B, Morgan P, Odian A, Piepke A, Pocar A, Prescott CY, Pushkin K, Rollin E, Rowson PC, Schmoll B, Sinclair D, Skarpaas K, Slutsky S, Stekhanov V, Strickland V, Swift M, Vuilleumier JL, Vuilleumier JM, Wichoski U, Wodin J, Yang L, Yen YR. A magnetically driven piston pump for ultra-clean applications. Rev Sci Instrum. 2011 Oct; 82(10):105114.
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  18. Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M, Posas F. Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. EMBO Rep. 2011 Oct; 12(10):1062-8.
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  19. Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):E952-61.
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  20. Ramadori G, Fujikawa T, Anderson J, Berglund ED, Frazao R, Michán S, Vianna CR, Sinclair DA, Elias CF, Coppari R. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metab. 2011 Sep 7; 14(3):301-12.
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  21. Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. SRT1720 improves survival and healthspan of obese mice. Sci Rep. 2011; 1:70.
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  22. Hua J, Guerin KI, Chen J, Michán S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2809-16.
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  23. Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R. Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem. 2011 Jun 3; 286(22):19270-9.
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  24. Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY). 2010 Dec; 2(12):914-23.
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  25. Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem. 2010 Nov 1; 111(4):1051-8.
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  26. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011 Feb; 66(2):191-201.
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  27. Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Dietary restriction: standing up for sirtuins. Science. 2010 Aug 27; 329(5995):1012-3; author reply 1013-4.
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  28. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707.
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  29. Le Couteur DG, Sinclair DA. A blueprint for developing therapeutic approaches that increase healthspan and delay death. J Gerontol A Biol Sci Med Sci. 2010 Jul; 65(7):693-4.
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  30. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21.
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  31. Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes. 2010 Apr; 59(4):829-35.
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  32. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010; 5:253-95.
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  33. Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging (Albany NY). 2009 Jun; 1(6):515-28.
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  34. Sinclair DA, Oberdoerffer P. The ageing epigenome: damaged beyond repair? Ageing Res Rev. 2009 Jul; 8(3):189-98.
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  35. Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, Milne JC, Sinclair DA, Westphal CH. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci. 2009 Mar; 18(3):514-25.
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  36. Jiménez-Hidalgo M, Santos-Ocaña C, Padilla S, Villalba JM, López-Lluch G, Martín-Montalvo A, Minor RK, Sinclair DA, de Cabo R, Navas P. NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell. 2009 Apr; 8(2):140-51.
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  37. Blagosklonny MV, Campisi J, Sinclair DA. Aging: past, present and future. Aging (Albany NY). 2009 Jan; 1(1):1-5.
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  38. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18.
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  39. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008 Aug; 8(2):157-68.
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  40. Howitz KT, Sinclair DA. Xenohormesis: sensing the chemical cues of other species. Cell. 2008 May 2; 133(3):387-91.
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  41. Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One. 2008; 3(4):e2020.
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  42. Sinclair DA. David A. Sinclair, Ph.D is interviewed by Vicki Glaser. Rejuvenation Res. 2008 Feb; 11(1):265-8.
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  43. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6.
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  44. Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 2007 Oct 2; 5(10):e261.
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  45. Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007 Sep 21; 130(6):1095-107.
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  46. Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S. Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation. Cell Death Differ. 2007 Dec; 14(12):2058-67.
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  47. Oberdoerffer P, Sinclair DA. The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol. 2007 Sep; 8(9):692-702.
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  48. Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 2007 Nov; 21(13):3629-39.
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  49. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79.
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  50. Michan S, Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem J. 2007 May 15; 404(1):1-13.
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  51. Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chiueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, Feinendegen L, Gardner DE, Hart RW, Hastings KL, Hayes AW, Hoffmann GR, Ives JA, Jaworowski Z, Johnson TE, Jonas WB, Kaminski NE, Keller JG, Klaunig JE, Knudsen TB, Kozumbo WJ, Lettieri T, Liu SZ, Maisseu A, Maynard KI, Masoro EJ, McClellan RO, Mehendale HM, Mothersill C, Newlin DB, Nigg HN, Oehme FW, Phalen RF, Philbert MA, Rattan SI, Riviere JE, Rodricks J, Sapolsky RM, Scott BR, Seymour C, Sinclair DA, Smith-Sonneborn J, Snow ET, Spear L, Stevenson DE, Thomas Y, Tubiana M, Williams GM, Mattson MP. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol. 2007 Jul 1; 222(1):122-8.
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  52. Medvedik O, Sinclair DA. Caloric restriction and life span determination of yeast cells. Methods Mol Biol. 2007; 371:97-109.
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  53. Sinclair D, Komaroff AL. Can we slow aging? Newsweek. 2006 Dec 11; 148(24):80, 82, 84.
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  54. Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA. Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell. 2007 Feb; 6(1):35-43.
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  55. North BJ, Sinclair DA. Sirtuins: a conserved key unlocking AceCS activity. Trends Biochem Sci. 2007 Jan; 32(1):1-4.
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  56. Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA. The role of protein arginine methylation in the formation of silent chromatin. Genes Dev. 2006 Dec 1; 20(23):3249-54.
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  57. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16; 444(7117):337-42.
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  58. Yang H, Lavu S, Sinclair DA. Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? Exp Gerontol. 2006 Aug; 41(8):718-26.
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  59. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 Jun; 5(6):493-506.
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  60. Sinclair DA, Lin SJ, Guarente L. Life-span extension in yeast. Science. 2006 Apr 14; 312(5771):195-7; author reply 195-7.
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  61. Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Sci Am. 2006 Mar; 294(3):48-51, 54-7.
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  62. Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1; 48(24):7789-95.
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  63. Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev. 2005 Sep; 126(9):987-1002.
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  64. Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science. 2005 Sep 16; 309(5742):1861-4.
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  65. Lamming DW, Wood JG, Sinclair DA. Small molecules that regulate lifespan: evidence for xenohormesis. Mol Microbiol. 2004 Aug; 53(4):1003-9.
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  66. Mizuno T, Kishimoto T, Shinzato T, Haw R, Chambers A, Wood J, Sinclair D, Uemura H. Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae. Yeast. 2004 Jul 30; 21(10):851-66.
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  67. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004 Aug 5; 430(7000):686-9.
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  68. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004 Jul 16; 305(5682):390-2.
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  69. Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell. 2004 Mar 12; 13(5):627-38.
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  70. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004 Mar 26; 303(5666):2011-5.
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  71. Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA. Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science. 2003 Dec 19; 302(5653):2124-6.
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  72. Sinclair DA. Cell biology. An age of instability. Science. 2003 Sep 26; 301(5641):1859-60.
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  73. Bitterman KJ, Medvedik O, Sinclair DA. Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev. 2003 Sep; 67(3):376-99, table of contents.
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  74. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11; 425(6954):191-6.
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  75. Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature. 2003 May 8; 423(6936):181-5.
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  76. Sinclair D. Is DNA cut out for a long life? Sci Aging Knowledge Environ. 2003 Apr 23; 2003(16):PE8.
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  77. Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem. 2002 Nov 22; 277(47):45099-107.
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  78. Sinclair DA. Paradigms and pitfalls of yeast longevity research. Mech Ageing Dev. 2002 Apr 30; 123(8):857-67.
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  79. Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem. 2002 May 24; 277(21):18881-90.
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  80. Wood JG, Sinclair DA. TPE or not TPE? It's no longer a question. Trends Pharmacol Sci. 2002 Jan; 23(1):1-4.
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  81. Cohen H, Sinclair DA. Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3174-9.
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  82. Singh M, Silva E, Schulze S, Sinclair DA, Fitzpatrick KA, Honda BM. Cloning and characterization of a new theta-class glutathione-S-transferase (GST) gene, gst-3, from Drosophila melanogaster. Gene. 2000 Apr 18; 247(1-2):167-73.
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  83. Lloyd VK, Sinclair DA, Wennberg R, Warner TS, Honda BM, Grigliatti TA. A genetic and molecular characterization of the garnet gene of Drosophila melanogaster. Genome. 1999 Dec; 42(6):1183-93.
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  84. Sinclair DA. Yeast aging research: recent advances and medical relevance. Cell Mol Life Sci. 1999 Nov 30; 56(9-10):807-16.
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  85. Ashrafi K, Sinclair D, Gordon JI, Guarente L. Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1999 Aug 3; 96(16):9100-5.
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  86. Milne TA, Sinclair DA, Brock HW. The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs. Mol Gen Genet. 1999 Jun; 261(4-5):753-61.
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  87. Mills KD, Sinclair DA, Guarente L. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell. 1999 May 28; 97(5):609-20.
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  88. Hong SP, Piper MD, Sinclair DA, Dawes IW. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif. J Biol Chem. 1999 Apr 9; 274(15):10523-32.
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  89. Lloyd VK, Sinclair DA, Grigliatti TA. Genomic imprinting and position-effect variegation in Drosophila melanogaster. Genetics. 1999 Apr; 151(4):1503-16.
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  90. Johnson FB, Sinclair DA, Guarente L. Molecular biology of aging. Cell. 1999 Jan 22; 96(2):291-302.
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  91. Stankunas K, Berger J, Ruse C, Sinclair DA, Randazzo F, Brock HW. The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development. 1998 Oct; 125(20):4055-66.
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  92. Clegg NJ, Honda BM, Whitehead IP, Grigliatti TA, Wakimoto B, Brock HW, Lloyd VK, Sinclair DA. Suppressors of position-effect variegation in Drosophila melanogaster affect expression of the heterochromatic gene light in the absence of a chromosome rearrangement. Genome. 1998 Aug; 41(4):495-503.
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  93. Salinas CA, Sinclair DA, O'Hare K, Brock HW. Characterization of a Drosophila homologue of the 160-kDa subunit of the cleavage and polyadenylation specificity factor CPSF. Mol Gen Genet. 1998 Apr; 257(6):672-80.
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  94. Sinclair DA, Mills K, Guarente L. Molecular mechanisms of yeast aging. Trends Biochem Sci. 1998 Apr; 23(4):131-4.
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  95. Warner TS, Sinclair DA, Fitzpatrick KA, Singh M, Devlin RH, Honda BM. The light gene of Drosophila melanogaster encodes a homologue of VPS41, a yeast gene involved in cellular-protein trafficking. Genome. 1998 Apr; 41(2):236-43.
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  96. Sinclair DA, Milne TA, Hodgson JW, Shellard J, Salinas CA, Kyba M, Randazzo F, Brock HW. The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. Development. 1998 Apr; 125(7):1207-16.
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  97. Sinclair DA, Clegg NJ, Antonchuk J, Milne TA, Stankunas K, Ruse C, Grigliatti TA, Kassis JA, Brock HW. Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster. Genetics. 1998 Jan; 148(1):211-20.
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  98. Sinclair D, Mills K, Guarente L. Aging in Saccharomyces cerevisiae. Annu Rev Microbiol. 1998; 52:533-60.
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  99. Sinclair DA, Guarente L. Extrachromosomal rDNA circles--a cause of aging in yeast. Cell. 1997 Dec 26; 91(7):1033-42.
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  100. Sinclair DA, Mills K, Guarente L. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science. 1997 Aug 29; 277(5330):1313-6.
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  101. Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell. 1997 May 2; 89(3):381-91.
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  102. Lloyd VK, Sinclair DA, Grigliatti TA. Competition between different variegating rearrangements for limited heterochromatic factors in Drosophila melanogaster. Genetics. 1997 Apr; 145(4):945-59.
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  103. McNeil JB, Zhang F, Taylor BV, Sinclair DA, Pearlman RE, Bognar AL. Cloning, and molecular characterization of the GCV1 gene encoding the glycine cleavage T-protein from Saccharomyces cerevisiae. Gene. 1997 Feb 20; 186(1):13-20.
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  104. Sinclair DA, Hong SP, Dawes IW. Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae. Mol Microbiol. 1996 Feb; 19(3):611-23.
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  105. Sinclair DA, Dawes IW. Genetics of the synthesis of serine from glycine and the utilization of glycine as sole nitrogen source by Saccharomyces cerevisiae. Genetics. 1995 Aug; 140(4):1213-22.
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  106. Campbell RB, Sinclair DA, Couling M, Brock HW. Genetic interactions and dosage effects of Polycomb group genes of Drosophila. Mol Gen Genet. 1995 Feb 6; 246(3):291-300.
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  107. Cheng NN, Sinclair DA, Campbell RB, Brock HW. Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster. Genetics. 1994 Dec; 138(4):1151-62.
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  108. McKeon J, Slade E, Sinclair DA, Cheng N, Couling M, Brock HW. Mutations in some Polycomb group genes of Drosophila interfere with regulation of segmentation genes. Mol Gen Genet. 1994 Sep 1; 244(5):474-83.
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  109. Sinclair DA, Kornfeld GD, Dawes IW. Yeast intragenic transcriptional control: activation and repression sites within the coding region of the Saccharomyces cerevisiae LPD1 gene. Mol Cell Biol. 1994 Jan; 14(1):214-25.
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  110. Sinclair DA, Dawes IW, Dickinson JR. Purification and characterization of the branched chain alpha-ketoacid dehydrogenase complex from Saccharomyces cerevisiae. Biochem Mol Biol Int. 1993 Dec; 31(5):911-22.
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  111. Clegg NJ, Whitehead IP, Brock JK, Sinclair DA, Mottus R, Stromotich G, Harrington MJ, Grigliatti TA. A cytogenetic analysis of chromosomal region 31 of Drosophila melanogaster. Genetics. 1993 May; 134(1):221-30.
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  112. Sinclair DA, Campbell RB, Nicholls F, Slade E, Brock HW. Genetic analysis of the additional sex combs locus of Drosophila melanogaster. Genetics. 1992 Apr; 130(4):817-25.
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  113. Sinclair DA, Ruddell AA, Brock JK, Clegg NJ, Lloyd VK, Grigliatti TA. A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster. Genetics. 1992 Feb; 130(2):333-44.
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  114. Sinclair D. Only winning battles, but hoping to win the war. Objectives of radical antivivisectionists? Trends Pharmacol Sci. 1990 Jun; 11(6):230.
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  115. Sinclair DA, Lloyd VK, Grigliatti TA. Characterization of mutations that enhance position-effect variegation in Drosophila melanogaster. Mol Gen Genet. 1989 Apr; 216(2-3):328-33.
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  116. Henderson DS, Bailey DA, Sinclair DA, Grigliatti TA. Isolation and characterization of second chromosome mutagen-sensitive mutations in Drosophila melanogaster. Mutat Res. 1987 Mar; 177(1):83-93.
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  117. Homyk T, Sinclair DA, Wong DT, Grigliatti TA. Recovery and Characterization of Temperature-Sensitive Mutations Affecting Adult Viability in DROSOPHILA MELANOGASTER. Genetics. 1986 Jun; 113(2):367-89.
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  118. Sinclair DA, Grigliatti TA. Investigation of the nature of P-induced male recombination in Drosophila melanogaster. Genetics. 1985 Jun; 110(2):257-79.
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  119. Moore GD, Sinclair DA, Grigliatti TA. Histone Gene Multiplicity and Position Effect Variegation in DROSOPHILA MELANOGASTER. Genetics. 1983 Oct; 105(2):327-44.
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  120. Sinclair DA, Suzuki DT, Grigliatti TA. Genetic and developmental analysis of a temperature-sensitive minute mutation of Drosophila melanogaster. Genetics. 1981 Mar-Apr; 97(3-4):581-606.
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