 Jeffrey Mark Drazen, M.D.
| Title | Parker B. Francis Distinguished Professor of Medicine |
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| Institution | Brigham and Women's Hospital |
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| Department | Medicine |
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| Address | New England Journal of Medicine
6th Floor
10 Shattuck St
Boston MA 02115
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| Phone | 617/487-6570 |
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| Fax | 617/739-9864 |
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| Title | Professor in the Department of Environmental Health |
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| Institution | Harvard School of Public Health |
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| Department | EH - Molecular+Integrative Phys Sci Prog |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Malhotra A, Drazen JM. High-frequency oscillatory ventilation on shaky ground. N Engl J Med. 2013 Feb 28; 368(9):863-5.
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Curfman GD, Morrissey S, Drazen JM. Affirmative action in the balance. N Engl J Med. 2013 Jan 3; 368(1):73-4.
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Kohane IS, Drazen JM, Campion EW. A glimpse of the next 100 years in medicine. N Engl J Med. 2012 Dec 27; 367(26):2538-9.
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Drazen JM, Curfman GD, Baden LR, Morrissey S. Compounding errors. N Engl J Med. 2012 Dec 20; 367(25):2436-7.
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Drazen JM. Believe the data. N Engl J Med. 2012 Sep 20; 367(12):1152-3.
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Drazen JM. Transparency for clinical trials--the TEST Act. N Engl J Med. 2012 Aug 30; 367(9):863-4.
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Park JA, Sharif AS, Tschumperlin DJ, Lau L, Limbrey R, Howarth P, Drazen JM. Tissue factor-bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo. J Allergy Clin Immunol. 2012 Dec; 130(6):1375-83.
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Drazen JM. Asthma: the paradox of heterogeneity. J Allergy Clin Immunol. 2012 May; 129(5):1200-1.
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von Mutius E, Drazen JM. A patient with asthma seeks medical advice in 1828, 1928, and 2012. N Engl J Med. 2012 Mar 1; 366(9):827-34.
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Ring J, Akdis C, Behrendt H, Lauener RP, Schäppi G, Akdis M, Ammann W, de Beaumont O, Bieber T, Bienenstock J, Blaser K, Bochner B, Bousquet J, Crameri R, Custovic A, Czerkinsky C, Darsow U, Denburg J, Drazen J, de Villiers EM, Fire A, Galli S, Haahtela T, zur Hausen H, Hildemann S, Holgate S, Holt P, Jakob T, Jung A, Kemeny M, Koren H, Leung D, Lockey R, Marone G, Mempel M, Menné B, Menz G, Mueller U, von Mutius E, Ollert M, O'Mahony L, Pawankar R, Renz H, Platts-Mills T, Roduit C, Schmidt-Weber C, Traidl-Hoffmann C, Wahn U, Rietschel E. Davos declaration: allergy as a global problem. Allergy. 2012 Feb; 67(2):141-3.
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Wood AJ, Drazen JM, Greene MF. The politics of emergency contraception. N Engl J Med. 2012 Jan 12; 366(2):101-2.
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Drazen JM. A step toward personalized asthma treatment. N Engl J Med. 2011 Sep 29; 365(13):1245-6.
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Bäck M, Dahlén SE, Drazen JM, Evans JF, Serhan CN, Shimizu T, Yokomizo T, Rovati GE. International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions. Pharmacol Rev. 2011 Sep; 63(3):539-84.
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Cozzi E, Ackerman KG, Lundequist A, Drazen JM, Boyce JA, Beier DR. The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated. Proc Natl Acad Sci U S A. 2011 Aug 2; 108(31):12787-92.
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Dahlén SE, Dahlén B, Drazen JM. Asthma treatment guidelines meet the real world. N Engl J Med. 2011 May 5; 364(18):1769-70.
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Curfman GD, Morrissey S, Drazen JM. Prescriptions, privacy, and the First Amendment. N Engl J Med. 2011 May 26; 364(21):2053-5.
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Ingelfinger JR, Drazen JM. Patient organizations and research on rare diseases. N Engl J Med. 2011 Apr 28; 364(17):1670-1.
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Shiomi T, Boudreault F, Padem N, Higashiyama S, Drazen JM, Tschumperlin DJ. Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts. Wound Repair Regen. 2011 Mar-Apr; 19(2):229-40.
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Shiomi T, Tschumperlin DJ, Park JA, Sunnarborg SW, Horiuchi K, Blobel CP, Drazen JM. TNF-a-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):376-85.
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Bousquet J, Mantzouranis E, Cruz AA, Aït-Khaled N, Baena-Cagnani CE, Bleecker ER, Brightling CE, Burney P, Bush A, Busse WW, Casale TB, Chan-Yeung M, Chen R, Chowdhury B, Chung KF, Dahl R, Drazen JM, Fabbri LM, Holgate ST, Kauffmann F, Haahtela T, Khaltaev N, Kiley JP, Masjedi MR, Mohammad Y, O'Byrne P, Partridge MR, Rabe KF, Togias A, van Weel C, Wenzel S, Zhong N, Zuberbier T. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 2010 Nov; 126(5):926-38.
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Campion EW, Drazen JM. [Peer review journals in the digital age]. Arch Bronconeumol. 2010 Nov; 46(11):569-70.
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Curfman GD, Morrissey S, Drazen JM. Products at risk. N Engl J Med. 2010 Oct 28; 363(18):1763.
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Campion EW, Miller PW, Costello J, Duff E, Drazen JM. The Journal from 1812 to 1989 at NEJM.org. N Engl J Med. 2010 Sep 16; 363(12):1175-6.
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Curfman GD, Morrissey S, Drazen JM. Sibutramine--another flawed diet pill. N Engl J Med. 2010 Sep 2; 363(10):972-4.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, Deangelis CD, Frizelle FA, Godlee F, Haug C, Hebert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures: the Updated ICMJE conflict of interest reporting form. Croat Med J. 2010 Aug; 51(4):287-8.
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Campion EW, Scott L, Bowab C, Fleming S, Blizzard TJ, Lamb C, Easley TJ, Drazen JM. The New NEJM.org. N Engl J Med. 2010 Aug 12; 363(7):677-8.
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Park JA, Drazen JM, Tschumperlin DJ. The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. J Biol Chem. 2010 Sep 24; 285(39):29817-25.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. N Z Med J. 2010 Jul 16; 123(1318):12-4.
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Drazen JM, Wood AJ. Don't mess with the DSMB. N Engl J Med. 2010 Jul 29; 363(5):477-8.
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Kazani S, Ware JH, Drazen JM, Taylor DR, Sears MR. The safety of long-acting beta-agonists: more evidence is needed. Respirology. 2010 Aug; 15(6):881-5; discussion 885-6.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Towards more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. Med J Aust. 2010 Jul 5; 193(1):7-8.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, Deangelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures: updated ICMJE conflict of interest reporting form. CMAJ. 2010 Jul 13; 182(10):E425.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van der Weyden MB, Zhaori G. Toward more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. JAMA. 2010 Jul 14; 304(2):212-3.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures: the updated ICMJE Conflict of Interest Reporting Form. Chin Med J (Engl). 2010 Jul; 123(13):1621-2.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van der Weyden MB, Zhaori G. Toward more uniform conflict disclosures--the updated ICMJE conflict of interest reporting form. N Engl J Med. 2010 Jul 8; 363(2):188-9.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures--the updated ICMJE reporting form for disclosure of potential conflicts of interest. Rev Med Chil. 2010 Jul; 138(7):801-3.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. Dan Med Bull. 2010 Jul; 57(7):A4168.
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Drazen JM, De Leeuw PW, Laine C, Mulrow C, Deangelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. Natl Med J India. 2010 Jul-Aug; 23(4):196-7.
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Drazen JM, de Leeuw PW, Laine C, Mulrow CD, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. Ann Intern Med. 2010 Aug 17; 153(4):268-9.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, DeAngelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, James A, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Toward more uniform conflict disclosures--the updated ICMJE conflict of interest reporting form. Tidsskr Nor Laegeforen. 2010 Jul 1; 130(13):E1-2.
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Drazen JM, de Leeuw PW, Laine C, Mulrow C, Deangelis CD, Frizelle FA, Godlee F, Haug C, Hébert PC, Horton R, Kotzin S, Marusic A, Reyes H, Rosenberg J, Sahni P, Van Der Weyden MB, Zhaori G. Towards more uniform conflict disclosures: the updated ICMJE conflict of interest reporting form. BMJ. 2010; 340:c3239.
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Kritek PA, Drazen JM. Clinical decisions. American Board of Internal Medicine maintenance of certification program--polling results. N Engl J Med. 2010 Apr 15; 362(15):e54.
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Bousquet J, Kiley J, Bateman ED, Viegi G, Cruz AA, Khaltaev N, Aït Khaled N, Baena-Cagnani CE, Barreto ML, Billo N, Canonica GW, Carlsen KH, Chavannes N, Chuchalin A, Drazen J, Fabbri LM, Gerbase MW, Humbert M, Joos G, Masjedi MR, Makino S, Rabe K, To T, Zhi L. Prioritised research agenda for prevention and control of chronic respiratory diseases. Eur Respir J. 2010 Nov; 36(5):995-1001.
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Drazen JM, Weinstein DF. Considering recertification. N Engl J Med. 2010 Mar 11; 362(10):946-7.
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von Mutius E, Drazen JM. Choosing asthma step-up care. N Engl J Med. 2010 Mar 18; 362(11):1042-3.
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Drazen JM, Van Der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, Deangelis CD. Uniform format for disclosure of competing interests in ICMJE journals. J Am Dent Assoc. 2010 Feb; 141(2):131-2.
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Drazen JM, Van Der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, Deangelis CD. Uniform format for disclosure of competing interests in ICMJE journals. Ann Intern Med. 2010 Jan 19; 152(2):125-6.
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Drazen JM, Van Der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, Deangelis CD. Uniform format for disclosure of competing interests in ICMJE journals. Med J Aust. 2009 Nov 2; 191(9):475-6.
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Uniform format for disclosure of competing interests in ICMJE journals. N Z Med J. 2009 Oct 30; 122(1305):12-4.
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Drazen JM, Van Der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, DeAngelis CD. Uniform format for disclosure of competing interests in ICMJE journals. Lancet. 2009 Oct 24; 374(9699):1395-6.
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Drazen JM, Van der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, DeAngelis CD. Uniform format for disclosure of competing interests in ICMJE journals. JAMA. 2010 Jan 6; 303(1):75-6.
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Drazen JM, Van Der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, DeAngelis CD. Uniform format for disclosure of competing interests in ICMJE journals. CMAJ. 2009 Oct 27; 181(9):565.
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Drazen JM, Van der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, DeAngelis CD. Uniform format for disclosure of competing interests in ICMJE journals. N Engl J Med. 2009 Nov 5; 361(19):1896-7.
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Drazen JM, Van Der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, DeAngelis CD. Disclosure of competing interests. BMJ. 2009; 339:b4144.
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Drazen JM, Van Der Weyden MB, Sahni P, Rosenberg J, Marusic A, Laine C, Kotzin S, Horton R, Hébert PC, Haug C, Godlee F, Frizelle FA, de Leeuw PW, DeAngelis CD. Uniform format for disclosure of competing interests in ICMJE Journals. Croat Med J. 2009 Oct; 50(5):427-8.
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Tantisira KG, Drazen JM. Genetics and pharmacogenetics of the leukotriene pathway. J Allergy Clin Immunol. 2009 Sep; 124(3):422-7.
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Curfman GD, Morrissey S, Malina D, Drazen JM. Health care reform 2009 at healthcarereform.nejm.org. N Engl J Med. 2009 Aug 13; 361(7):709-10.
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Curfman GD, Morrissey S, Drazen JM. Tobacco, public health, and the FDA. N Engl J Med. 2009 Jul 23; 361(4):402-3.
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Baden LR, Drazen JM, Kritek PA, Curfman GD, Morrissey S, Campion EW. H1N1 influenza A disease--information for health professionals. N Engl J Med. 2009 Jun 18; 360(25):2666-7.
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Drazen JM, O'Byrne PM. Risks of long-acting beta-agonists in achieving asthma control. N Engl J Med. 2009 Apr 16; 360(16):1671-2.
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Curfman GD, Morrissey S, Drazen JM. The Medical Device Safety Act of 2009. N Engl J Med. 2009 Apr 9; 360(15):1550-1.
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Hamel MB, Drazen JM, Epstein AM. The growth of hospitalists and the changing face of primary care. N Engl J Med. 2009 Mar 12; 360(11):1141-3.
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Drazen JM, Desai NR, Green P. Fighting on. N Engl J Med. 2009 Jan 29; 360(5):444-5.
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Curfman GD, Morrissey S, Greene MF, Drazen JM. Physicians and the First Amendment. N Engl J Med. 2008 Dec 4; 359(23):2484-5.
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Curfman GD, Morrissey S, Drazen JM. The FDA and tobacco regulation. N Engl J Med. 2008 Sep 4; 359(10):1056-7.
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Drazen JM, D'Agostino RB, Ware JH, Morrissey S, Curfman GD. Ezetimibe and cancer--an uncertain association. N Engl J Med. 2008 Sep 25; 359(13):1398-9.
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Morrissey S, Curfman GD, Drazen JM. Health of the nation--coverage for all Americans. N Engl J Med. 2008 Aug 21; 359(8):855-6.
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Curfman GD, Morrissey S, Drazen JM. Cardiac transplantation in infants. N Engl J Med. 2008 Aug 14; 359(7):749-50.
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Drazen JM, Morrissey S, Curfman GD. Guns and health. N Engl J Med. 2008 Jul 31; 359(5):517-8.
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Curfman GD, Morrissey S, Drazen JM. Why doctors should worry about preemption. N Engl J Med. 2008 Jul 3; 359(1):1-3.
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Curfman GD, Morrissey S, Annas GJ, Drazen JM. Peer review in the balance. N Engl J Med. 2008 May 22; 358(21):2276-7.
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Schwartz RS, Curfman GD, Morrissey S, Drazen JM. Full disclosure and the funding of biomedical research. N Engl J Med. 2008 Apr 24; 358(17):1850-1.
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Drazen JM, Jarcho JA, Morrissey S, Curfman GD. Cholesterol lowering and ezetimibe. N Engl J Med. 2008 Apr 3; 358(14):1507-8.
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Curfman GD, Morrissey S, Drazen JM. Handgun violence, public health, and the law. N Engl J Med. 2008 Apr 3; 358(14):1503-4.
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Hunter DJ, Khoury MJ, Drazen JM. Letting the genome out of the bottle--will we get our wish? N Engl J Med. 2008 Jan 10; 358(2):105-7.
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Curfman GD, Morrissey S, Drazen JM. Physicians and execution. N Engl J Med. 2008 Jan 24; 358(4):403-4.
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Curfman GD, Morrissey S, Drazen JM. A pivotal medical-device case. N Engl J Med. 2008 Jan 3; 358(1):76-7.
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Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008 Jan; 31(1):143-78.
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Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM. Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med. 2007 Nov 22; 357(21):2189-94.
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Drazen JM, Morrissey S, Curfman GD. Open clinical trials. N Engl J Med. 2007 Oct 25; 357(17):1756-7.
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Curfman GD, Morrissey S, Drazen JM. No child left uncovered. N Engl J Med. 2007 Sep 6; 357(10):1036-7.
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Curfman GD, Morrissey S, Drazen JM. Safer drugs for the American people. N Engl J Med. 2007 Aug 9; 357(6):602-3.
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[Clinical trial registration: looking back and moving ahead]. Ugeskr Laeger. 2007 Jun 25; 169(26):2505-6.
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Fredenburgh LE, Campion EW, Drazen JM. Clinical Decisions. Mild persistent asthma--polling results. N Engl J Med. 2007 Jul 12; 357(2):179-80.
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Laine C, Horton R, De Angelis C, Drazen JM, Frizelle FA, Godlee F, Haug C, Hébert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van Der Weyden MB, Verheugt FW. Clinical trial registration: looking back and moving ahead. Med J Aust. 2007 Jun 18; 186(12):612-3.
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Laine C, Horton R, DeAngelis C, Drazen J, Frizelle F, Godlee F, Haug C, Hébert P, Kotzin S, Marusic A, Sahni P, Schroeder T, Sox H, Van der Weyden M, Verheugt F. Clinical trial registration: looking back and moving ahead. N Z Med J. 2007; 120(1256):U2586.
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Laine C, Horton R, DeAngelis CD, Drazen JM, Frizelle FA, Godlee F, Haug C, Hébert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van der Weyden MB, Verheugt FW. Clinical trial registration: looking back and moving ahead. Lancet. 2007 Jun 9; 369(9577):1909-11.
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Drazen JM, Morrissey S, Curfman GD. Rosiglitazone--continued uncertainty about safety. N Engl J Med. 2007 Jul 5; 357(1):63-4.
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Laine C, Horton R, DeAngelis CD, Drazen JM, Frizelle FA, Godlee F, Haug C, Hébert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van der Weyden MB, Verheugt FW. Clinical trial registration. BMJ. 2007 Jun 9; 334(7605):1177-8.
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Laine C, Horton R, DeAngelis CD, Drazen JM, Frizelle FA, Godlee F, Haug C, Hébert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van der Weyden MB, Verheugt FW. Clinical trial registration: looking back and moving ahead. JAMA. 2007 Jul 4; 298(1):93-4.
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Laine C, De Angelis C, Delamothe T, Drazen JM, Frizelle FA, Haug C, Hébert PC, Horton R, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van der Weyden MB, Verheugt FW. Clinical trial registration: looking back and moving ahead. Ann Intern Med. 2007 Aug 21; 147(4):275-7.
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Laine C, Horton R, DeAngelis CD, Drazen JM, Frizelle FA, Godlee F, Haug C, Hébert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van der Weyden MB, Verheugt FW. Clinical trial registration--looking back and moving ahead. N Engl J Med. 2007 Jun 28; 356(26):2734-6.
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Laine C, Horton R, DeAngelis CD, Drazen JM, Frizelle FA, Godlee F, Haug C, Hébert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van der Weyden MB, Verheugt FW. Clinical trial registration: looking back and moving ahead. CMAJ. 2007 Jul 3; 177(1):57-8.
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Laine C, Horton R, DeAngelis CD, Drazen JM, Frizelle FA, Godlee F, Haug C, Hébert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van Der Weyden MB, Verheugt FW. Clinical trial registration: looking back and moving ahead. Croat Med J. 2007 Jun; 48(3):289-91.
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Baden LR, Curfman GD, Morrissey S, Drazen JM. Human papillomavirus vaccine--opportunity and challenge. N Engl J Med. 2007 May 10; 356(19):1990-1.
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Drazen JM. Government in medicine. N Engl J Med. 2007 May 24; 356(21):2195.
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Curfman GD, Morrissey S, Jarcho JA, Drazen JM. Drug-eluting coronary stents--promise and uncertainty. N Engl J Med. 2007 Mar 8; 356(10):1059-60.
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Drazen JM, Zarin DA. Salvation by registration. N Engl J Med. 2007 Jan 11; 356(2):184-5.
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Drazen JM. Research replication. N Engl J Med. 2006 Nov 23; 355(21):2252-3.
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Curfman GD, Morrissey S, Drazen JM. Retraction: Sudbø J et al. DNA content as a prognostic marker in patients with oral leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The influence of resection and aneuploidy on mortality in oral leukoplakia. N Engl J Med 2004;350:1405-13. N Engl J Med. 2006 Nov 2; 355(18):1927.
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Curfman GD, Morrissey S, Drazen JM. Blueprint for a stronger Food and Drug Administration. N Engl J Med. 2006 Oct 26; 355(17):1821.
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Drazen JM. Response to 'Lapses at the NEJM'. J R Soc Med. 2006 Oct; 99(10):485; author reply 485.
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Chiang N, Serhan CN, Dahlén SE, Drazen JM, Hay DW, Rovati GE, Shimizu T, Yokomizo T, Brink C. The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev. 2006 Sep; 58(3):463-87.
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Drazen JM. Volunteers at risk. N Engl J Med. 2006 Sep 7; 355(10):1060-1.
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Drazen JM, Lenfant C, Hurd SS. Acorns and inhalers: the Asthma Clinical Research Network. J Allergy Clin Immunol. 2007 Jan; 119(1):28-9.
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Chu EK, Cheng J, Foley JS, Mecham BH, Owen CA, Haley KJ, Mariani TJ, Kohane IS, Tschumperlin DJ, Drazen JM. Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2006 Dec; 35(6):628-38.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Haematologica. 2006 Mar; 91(3):293-5.
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Curfman GD, Morrissey S, Drazen JM. Expression of concern reaffirmed. N Engl J Med. 2006 Mar 16; 354(11):1193.
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Curfman GD, Morrissey S, Drazen JM. Expression of concern: Sudbø J et al. DNA content as a prognostic marker in patients with oral leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. the influence of resection and aneuploidy on mortality in oral leukoplakia. N Engl J Med 2004;350:1405-13. N Engl J Med. 2006 Feb 9; 354(6):638.
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Tschumperlin DJ, Drazen JM. Chronic effects of mechanical force on airways. Annu Rev Physiol. 2006; 68:563-83.
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Drazen JM, Wood AJ. Trial registration report card. N Engl J Med. 2005 Dec 29; 353(26):2809-11.
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Curfman GD, Morrissey S, Drazen JM. Expression of concern: Bombardier et al., "Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis," N Engl J Med 2000;343:1520-8. N Engl J Med. 2005 Dec 29; 353(26):2813-4.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van der Weyden MB. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Saudi Med J. 2005 Dec; 26(12):1857-9.
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Wood AJ, Drazen JM, Greene MF. A sad day for science at the FDA. N Engl J Med. 2005 Sep 22; 353(12):1197-9.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Is this clinical trial fully registered? A statement from the international committee of medical journal editors. Croat Med J. 2005 Aug; 46(4):499-501.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Ann Intern Med. 2005 Jul 19; 143(2):146-8.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. [Is this clinical trial fully registered?]. Tidsskr Nor Laegeforen. 2005 Jun 30; 125(13):1877-8.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Med J Aust. 2005 Jun 20; 182(12):609-10.
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Drazen JM. Patients at risk. N Engl J Med. 2005 Jul 28; 353(4):417.
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De Angelis C, Drazen J, Frizelle F, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke J, Schroeder T, Sox H, Van der Weyden M. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. N Z Med J. 2005 Jun 3; 118(1216):U1500.
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DeAngelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Arch Otolaryngol Head Neck Surg. 2005 Jun; 131(6):479-80.
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Deangelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. JAMA. 2005 Jun 15; 293(23):2927-9.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Is this clinical trial fully registered?--A statement from the International Committee of Medical Journal Editors. N Engl J Med. 2005 Jun 9; 352(23):2436-8.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. CMAJ. 2005 Jun 21; 172(13):1700-2.
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Drazen JM. Using every resource to care for our casualties. N Engl J Med. 2005 May 19; 352(20):2121.
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Choudhry S, Avila PC, Nazario S, Ung N, Kho J, Rodriguez-Santana JR, Casal J, Tsai HJ, Torres A, Ziv E, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Castro RA, Selman M, Weiss ST, Ford JG, Drazen JM, Rodriguez-Cintron W, Chapela R, Silverman EK, Burchard EG. CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma. Am J Respir Crit Care Med. 2005 Jul 15; 172(2):173-82.
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De Angelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Lancet. 2005 May 28-Jun 3; 365(9474):1827-9.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Stroke. 2005 Apr; 36(4):924-5.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Hypertension. 2005 Apr; 45(4):631-2.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Arterioscler Thromb Vasc Biol. 2005 Apr; 25(4):873-4.
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Chu EK, Drazen JM. Asthma: one hundred years of treatment and onward. Am J Respir Crit Care Med. 2005 Jun 1; 171(11):1202-8.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Circ Res. 2005 Mar 18; 96(5):600-1.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Circulation. 2005 Mar 15; 111(10):1337-8.
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Drazen JM, Klempner MS. Disaster, water, cholera, vaccines, and hope. N Engl J Med. 2005 Feb 24; 352(8):827.
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Drazen JM. COX-2 inhibitors--a lesson in unexpected problems. N Engl J Med. 2005 Mar 17; 352(11):1131-2.
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Chu EK, Foley JS, Cheng J, Patel AS, Drazen JM, Tschumperlin DJ. Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner. Am J Respir Cell Mol Biol. 2005 May; 32(5):373-80.
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Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR. Interacting genetic loci cause airway hyperresponsiveness. Physiol Genomics. 2005 Mar 21; 21(1):105-11.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Am J Phys Med Rehabil. 2005 Jan; 84(1):3-4.
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Deangelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Arch Dermatol. 2005 Jan; 141(1):76-7.
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Drazen JM. Your health in the 21st century. Getting all the facts on drugs. Newsweek. 2005; 145(26A):72.
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Tantisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, Peng SL, Drazen JM, Glimcher LH, Weiss ST. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18099-104.
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Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, Lilly C, Matallana H, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Drazen JM, Rodriguez-Cintron W, Silverman EK, Burchard EG. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):563-70.
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Drazen JM. Awake and informed. N Engl J Med. 2004 Oct 28; 351(18):1884.
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Drazen JM. Embryonic stem-cell research--the case for federal funding. N Engl J Med. 2004 Oct 21; 351(17):1789-90.
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Drazen JM. Presentation of the 2004 Kober Medal to K. Frank Austen. J Clin Invest. 2004 Oct; 114(8):1174-6.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Croat Med J. 2004 Oct; 45(5):531-2.
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Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 2004 Oct 23-29; 364(9444):1505-12.
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Drazen JM, Curfman GD. Public access to biomedical research. N Engl J Med. 2004 Sep 23; 351(13):1343.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. [Clinical trial registration: a statement from the International Committee of Medical Journal Editors]. Tidsskr Nor Laegeforen. 2004 Sep 23; 124(18):2339.
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DeAngelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Med J Aust. 2004 Sep 20; 181(6):293-4.
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DeAngelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, van der Weyden MB. [Registration of clinical trials: a statement from the International Committee of Medical Journal Editors]. Ned Tijdschr Geneeskd. 2004 Sep 18; 148(38):1870-1.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. CMAJ. 2004 Sep 14; 171(6):606-7.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. [Clinical trial registration: a statement for the International Committee of Medical Journal Editors]. Ugeskr Laeger. 2004 Sep 13; 166(38):3283-4.
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Drazen JM. Editorial independence at the BMJ: NEJM editor says facts in letter are wrong and accusations reckless... BMJ. 2004 Sep 11; 329(7466):624.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. N Z Med J. 2004 Sep 10; 117(1201):U1054.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. N Engl J Med. 2004 Sep 16; 351(12):1250-1.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Ann Intern Med. 2004 Sep 21; 141(6):477-8.
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DeAngelis CD, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. JAMA. 2004 Sep 15; 292(11):1363-4.
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De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Lancet. 2004 Sep 11-17; 364(9438):911-2.
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Bates J, Irvin C, Brusasco V, Drazen J, Fredberg J, Loring S, Eidelman D, Ludwig M, Macklem P, Martin J, Milic-Emili J, Hantos Z, Hyatt R, Lai-Fook S, Leff A, Solway J, Lutchen K, Suki B, Mitzner W, Paré P, Pride N, Sly P. The use and misuse of Penh in animal models of lung disease. Am J Respir Cell Mol Biol. 2004 Sep; 31(3):373-4.
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Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet. 2004 Jul 1; 13(13):1353-9.
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Tschumperlin DJ, Dai G, Maly IV, Kikuchi T, Laiho LH, McVittie AK, Haley KJ, Lilly CM, So PT, Lauffenburger DA, Kamm RD, Drazen JM. Mechanotransduction through growth-factor shedding into the extracellular space. Nature. 2004 May 6; 429(6987):83-6.
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Drazen JM, Greene MF, Wood AJ. The FDA, politics, and plan B. N Engl J Med. 2004 Apr 8; 350(15):1561-2.
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Ingelfinger JR, Drazen JM. Registry research and medical privacy. N Engl J Med. 2004 Apr 1; 350(14):1452-3.
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Kikuchi T, Shively JD, Foley JS, Drazen JM, Tschumperlin DJ. Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L119-26.
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Hjoberg J, Shore S, Kobzik L, Okinaga S, Hallock A, Vallone J, Subramaniam V, De Sanctis GT, Elias JA, Drazen JM, Silverman ES. Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness. J Appl Physiol. 2004 Jul; 97(1):249-59.
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Phimister EG, Drazen JM. Two fillips for human embryonic stem cells. N Engl J Med. 2004 Mar 25; 350(13):1351-2.
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Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T. International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. Pharmacol Rev. 2004 Mar; 56(1):149-57.
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Drazen JM. Inserting government between patient and physician. N Engl J Med. 2004 Jan 8; 350(2):178-9.
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Weiss ST, Lake SL, Silverman ES, Silverman EK, Richter B, Drazen JM, Tantisira KG. Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses. Proc Am Thorac Soc. 2004; 1(4):364-7.
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Drazen JM, Ingelfinger JR. Grants, politics, and the NIH. N Engl J Med. 2003 Dec 4; 349(23):2259-61.
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Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004 Feb 1; 169(3):386-92.
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Drazen JM, Ingelfinger JR, Curfman GD. Removal of expression of concern: Schiffl H, et Al. Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 2002;346:305-10. N Engl J Med. 2003 Nov 13; 349(20):1965.
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Silverman EK, Kwiatkowski DJ, Sylvia JS, Lazarus R, Drazen JM, Lange C, Laird NM, Weiss ST. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol. 2003 Nov; 112(5):870-6.
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Thompson MD, Storm van's Gravesande K, Galczenski H, Burnham WM, Siminovitch KA, Zamel N, Slutsky A, Drazen JM, George SR, Evans JF, O'Dowd BF. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. Pharmacogenetics. 2003 Oct; 13(10):641-9.
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Drazen JM. Decisions at the end of life. N Engl J Med. 2003 Sep 18; 349(12):1109-10.
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Shore SA, Drazen JM. Beta-agonists and asthma: too much of a good thing? J Clin Invest. 2003 Aug; 112(4):495-7.
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Drazen JM. SARS--looking back over the first 100 days. N Engl J Med. 2003 Jul 24; 349(4):319-20.
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Drazen JM. Legislative myopia on stem cells. N Engl J Med. 2003 Jul 17; 349(3):300.
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Silverman ES, Drazen JM. Immunostimulatory DNA for asthma: better than eating dirt. Am J Respir Cell Mol Biol. 2003 Jun; 28(6):645-7.
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Curfman GD, Morrissey S, Drazen JM. Notice of duplicate publication. N Engl J Med. 2003 May 29; 348(22):2254.
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Drazen JM, Ingelfinger JR, Curfman GD. Expression of concern: Schiffl H, et Al. Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 2002;346:305-10. N Engl J Med. 2003 May 22; 348(21):2137.
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Drazen JM, Epstein AM. Guidance concerning surgery for emphysema. N Engl J Med. 2003 May 22; 348(21):2134-6.
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Drazen JM, Campion EW. SARS, the Internet, and the Journal. N Engl J Med. 2003 May 15; 348(20):2029.
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Storm van's Gravesande K, Wechsler ME, Grasemann H, Silverman ES, Le L, Palmer LJ, Drazen JM. Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels. Am J Respir Crit Care Med. 2003 Jul 15; 168(2):228-31.
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Drazen JM. Controlling research trials. N Engl J Med. 2003 Apr 3; 348(14):1377-80.
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Drazen JM. Case clusters of the severe acute respiratory syndrome. N Engl J Med. 2003 May 15; 348(20):e6-7.
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Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T. International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev. 2003 Mar; 55(1):195-227.
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Drazen JM. Asthma and the human genome project: summary of the 45th Annual Thomas L. Petty Aspen Lung Conference. Chest. 2003 Mar; 123(3 Suppl):447S-9S.
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Drazen JM. Inappropriate advertising of dietary supplements. N Engl J Med. 2003 Feb 27; 348(9):777-8.
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Curfman GD, Morrissey S, Drazen JM. Notice of retraction. N Engl J Med. 2003 Mar 6; 348(10):945.
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Tschumperlin DJ, Shively JD, Kikuchi T, Drazen JM. Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. Am J Respir Cell Mol Biol. 2003 Feb; 28(2):142-9.
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Grasemann H, Storm van's Gravesande K, Buscher R, Drazen JM, Ratjen F. Effects of sex and of gene variants in constitutive nitric oxide synthases on exhaled nitric oxide. Am J Respir Crit Care Med. 2003 Apr 15; 167(8):1113-6.
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Kalayci O, Wechsler M, Galper B, Hong C, Israel E, Drazen JM, Lilly CM. LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter. Adv Exp Med Biol. 2003; 525:11-4.
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Drazen JM. Leukotrienes in asthma. Adv Exp Med Biol. 2003; 525:1-5.
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Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt B, Szczeklik W, Drazen JM, Serhan CN. Lipoxins and aspirin-triggered lipoxins in airway responses. Adv Exp Med Biol. 2003; 525:19-23.
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Silverman ES, Baron RM, Palmer LJ, Le L, Hallock A, Subramaniam V, Riese RJ, McKenna MD, Gu X, Libermann TA, Tugores A, Haley KJ, Shore S, Drazen JM, Weiss ST. Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. Am J Respir Cell Mol Biol. 2002 Dec; 27(6):697-704.
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DeMeo DL, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird N, Weiss ST. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48.
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Drazen JM. A milestone in tuberculosis control. N Engl J Med. 2002 Oct 31; 347(18):1444.
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Drazen JM. Institutions, contracts, and academic freedom. N Engl J Med. 2002 Oct 24; 347(17):1362-3.
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Mushlin SB, Drazen JM, Samuels MA, Mark EJ. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2002. A 28-year-old woman with ocular inflammation, fever, and headache. N Engl J Med. 2002 Oct 24; 347(17):1350-7.
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Drazen JM, Epstein AM. Rethinking medical training--the critical work ahead. N Engl J Med. 2002 Oct 17; 347(16):1271-2.
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Baron RM, Palmer LJ, Tantisira K, Gabriel S, Sonna LA, Le L, Hallock A, Libermann TA, Drazen JM, Weiss ST, Silverman ES. DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma. Am J Respir Crit Care Med. 2002 Oct 1; 166(7):927-32.
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Hare JM, Nguyen GC, Massaro AF, Drazen JM, Stevenson LW, Colucci WS, Fang JC, Johnson W, Givertz MM, Lucas C. Exhaled nitric oxide: a marker of pulmonary hemodynamics in heart failure. J Am Coll Cardiol. 2002 Sep 18; 40(6):1114-9.
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Slutsky AS, Drazen JM. Ventilation with small tidal volumes. N Engl J Med. 2002 Aug 29; 347(9):630-1.
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Grasemann H, Storm van's Gravesande K, Buscher R, Knauer N, Silverman ES, Palmer LJ, Drazen JM, Ratjen F. Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. Am J Respir Crit Care Med. 2003 Feb 1; 167(3):390-4.
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Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt BA, Szczeklik W, Drazen JM, Serhan CN. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med. 2002 Sep; 8(9):1018-23.
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Hrousis CA, Wiggs BJ, Drazen JM, Parks DM, Kamm RD. Mucosal folding in biologic vessels. J Biomech Eng. 2002 Aug; 124(4):334-41.
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Drazen JM, Weiss ST. Genetics: inherit the wheeze. Nature. 2002 Jul 25; 418(6896):383-4.
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Drazen JM, Curfman GD. Retraction: Barbaro et Al. Incidence of dilated cardiomyopathy and detection of HIV in myocardial cells of HIV-positive patients. N Engl J Med 1998;339:1093-9. N Engl J Med. 2002 Jul 11; 347(2):140.
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Drazen JM, Curfman GD. On authors and contributors. N Engl J Med. 2002 Jul 4; 347(1):55.
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Drazen JM. Who owns the data in clinical trial? Sci Eng Ethics. 2002 Jul; 8(3):407-11.
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Shikanai T, Silverman ES, Morse BW, Lilly CM, Inoue H, Drazen JM. Sequence variants in the FcepsilonRI alpha chain gene. J Appl Physiol. 2002 Jul; 93(1):37-41.
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Deykin A, Massaro AF, Drazen JM, Israel E. Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. Am J Respir Crit Care Med. 2002 Jun 15; 165(12):1597-601.
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Drazen JM, Curfman GD. Financial associations of authors. N Engl J Med. 2002 Jun 13; 346(24):1901-2.
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Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF, Peters SP, Sorkness CA. Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med. 2002 May 15; 165(10):1377-83.
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Tschumperlin DJ, Shively JD, Swartz MA, Silverman ES, Haley KJ, Raab G, Drazen JM. Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L904-11.
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Palmer LJ, Silverman ES, Weiss ST, Drazen JM. Pharmacogenetics of asthma. Am J Respir Crit Care Med. 2002 Apr 1; 165(7):861-6.
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Drazen JM. Smallpox and bioterrorism. N Engl J Med. 2002 Apr 25; 346(17):1262-3.
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Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet. 2002 May; 70(5):1229-39.
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Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet. 2002 Mar 15; 11(6):623-32.
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Grasemann H, Storm van's Gravesande K, Gärtig S, Kirsch M, Büscher R, Drazen JM, Ratjen F. Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism. Nitric Oxide. 2002 Mar; 6(2):236-41.
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Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RF, Mauger E, Peters SP, Sorkness CA. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 2002 Mar; 109(3):410-8.
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Drazen JM. The consumer and the learned intermediary in health care. N Engl J Med. 2002 Feb 14; 346(7):523-4.
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Drazen JM. Sleep apnea syndrome. N Engl J Med. 2002 Feb 7; 346(6):390.
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Oguma T, Asano K, Shiomi T, Fukunaga K, Suzuki Y, Nakamura M, Matsubara H, Sheldon HK, Haley KJ, Lilly CM, Drazen JM, Yamaguchi K. Cyclooxygenase-2 expression during allergic inflammation in guinea-pig lungs. Am J Respir Crit Care Med. 2002 Feb 1; 165(3):382-6.
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Drazen JM. Allocating limited resources. N Engl J Med. 2002 Jan 31; 346(5):368.
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Campion EW, Anderson K, Drazen JM. Advances in our electronic pages. N Engl J Med. 2002 Jan 31; 346(5):362.
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Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002 Jan 11; 295(5553):336-8.
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Drazen JM. Anti-leukotrienes as novel anti-inflammatory treatments in asthma. Adv Exp Med Biol. 2002; 507:217-21.
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Davidoff F, DeAngelis CD, Drazen JM, Hoey J, Højgaard L, Horton R, Kotzin S, Nicholls MG, Nylenna M, Overbeke AJ, Sox HC, Van der Weyden MB, Wilkes MS. Sponsorship, authorship, and accountability. Obstet Gynecol. 2001 Dec; 98(6):1143-6.
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Chinchilli VM, Drazen JM, Fish JE, Lemanske RF, Lazarus SC, Martin RJ. The clinical trials in the initial five-year award period of the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec; 22(6 Suppl):126S-34S.
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Nakamura H, Luster AD, Nakamura T, In KH, Sonna LA, Deykin A, Israel E, Drazen JM, Lilly CM. Variant eotaxin: its effects on the asthma phenotype. J Allergy Clin Immunol. 2001 Dec; 108(6):946-53.
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Forand PE, Kunselman SJ, Drazen JM, Israel E, Pillari A, Armstrong TJ, Britton TB. Genetic analysis in the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec; 22(6 Suppl):196S-206S.
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Tschumperlin DJ, Drazen JM. Mechanical stimuli to airway remodeling. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S90-4.
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Barr RG, Cooper DM, Speizer FE, Drazen JM, Camargo CA. Beta(2)-adrenoceptor polymorphism and body mass index are associated with adult-onset asthma in sedentary but not active women. Chest. 2001 Nov; 120(5):1474-9.
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Davidoff F, DeAngelis CD, Drazen JM, Hoey J, Hjgaard L, Horton R, Kotzin S, Nicholls MG, Nylenna M, Overbeke AJ, Sox HC, Van Der Weyden MB, Wilkes MS. [Sponsorship, authorship and accountability]. Rev Esp Cardiol. 2001 Nov; 54(11):1247-50.
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Davidoff F, DeAngelis CD, Drazen JM, Nicholls MG, Hoey J, Højgaard L, Horton R, Kotzin S, Nylenna M, Overbeke JP, Sox HC, Van der Weyden MB, Wilkes MS. Sponsorship, authorship and accountability. Lakartidningen. 2001 Oct 24; 98(43):4694-6.
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Drazen JM. Surgery for emphysema--not for everyone. N Engl J Med. 2001 Oct 11; 345(15):1126-7.
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Baron R, Silverman ES, Grasemann H, Collins T, Drazen JM. DNA sequence variants of the platelet-derived growth factor A-chain gene. Clin Exp Allergy. 2001 Oct; 31(10):1501-8.
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Davidoff F, DeAngelis CD, Drazen JM, Hoey J, Højgaard L, Horton R, Kotzin S, Nicholls MG, Nylenna M, Overbeke AJ, Sox HC, Van Der Weyden MB, Wilkes MS. Sponsorship, authorship, and accountability. Arch Otolaryngol Head Neck Surg. 2001 Oct; 127(10):1178-80.
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Davidoff F, DeAngelis CD, Drazen JM, Hoey J, Højgaard L, Horton R, Kotzin S, Nylenna M, Overbeke AJ, Sox HC, Sox HC, Van Der Weyden MB, Wilkes MS. Sponsorship, authorship, and accountability. Ann Intern Med. 2001 Sep 18; 135(6):463-6.
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Davidoff F, DeAngelis CD, Drazen JM, Nicholls MG, Hoey J, Højgaard L, Horton R, Kotzin S, Nylenna M, Overbeke AJ, Sox HC, Van Der Weyden MB, Wilkes MS. Sponsorship, authorship and accountability. CMAJ. 2001 Sep 18; 165(6):786-8.
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Davidoff F, DeAngelis CD, Drazen JM, Nicholls MG, Hoey J, Højgaard L, Horton R, Kotzin S, Nylenna M, Overbeke AJ, Sox HC, Van Der Weyden MB, Wilkes MS. Sponsorship, authorship and accountability. Med J Aust. 2001 Sep 17; 175(6):294-6.
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Davidoff F, DeAngelis CD, Drazen JM, Hoey J, Højgaard L, Horton R, Kotzin S, Nicholls MG, Nylenna M, Overbeke AJ, Sox HC, Van Der Weyden MB, Wilkes MS. Sponsorship, authorship, and accountability. Lancet. 2001 Sep 15; 358(9285):854-6.
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Curfman GD, Drazen JM. Too close to call. N Engl J Med. 2001 Sep 13; 345(11):832.
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Davidoff F, DeAngelis CD, Drazen JM, Nicholls MG, Hoey J, Højgaard L, Horton R, Kotzin S, Nylenna M, Overbeke AJ, Sox HC, Van Der Weyden MB, Wilkes MS. Sponsorship, authorship, and accountability. N Engl J Med. 2001 Sep 13; 345(11):825-6; discussion 826-7.
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Davidoff F, DeAngelis CD, Drazen JM, Hoey J, Højgaard L, Horton R, Kotzin S, Nicholls MG, Nylenna M, Overbeke AJ, Sox HC, Van Der Weyden MB, Wilkes MS. Sponsorship, authorship, and accountability. JAMA. 2001 Sep 12; 286(10):1232-4.
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Davidoff F, DeAngelis CD, Drazen JM, Hoey J, Højgaard L, Horton R, Kotzin S, Nicholls MG, Nylenna M, Overbeke JP, Sox HC, van der Weyden MB, Wilkes MS. [Sponsorship, authorship and accountability]. Tidsskr Nor Laegeforen. 2001 Sep 10; 121(21):2531-2.
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Davidoff F, Deangelis CD, Drazen JM, Nicholls MG, Hoey J, Hojgaard L, Horton R, Kotzin S, Nylenna M, Overbeke JP, Sox HC, Van der Weyden MB, Wilkes MS. Sponsorship, authorship, and accountability. Ugeskr Laeger. 2001 Sep 10; 163(37):4983-5.
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Steinbrook R, Drazen JM. AIDS--will the next 20 years be different? N Engl J Med. 2001 Jun 7; 344(23):1781-2.
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Yu H, Merchant B, Scheffel C, Yandava C, Drazen JM, Huff J. Automated detection of single nucleotide polymorphism in beta-2 adrenergic receptor gene using LCx(R). Clin Chim Acta. 2001 Jun; 308(1-2):17-24.
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Swartz MA, Tschumperlin DJ, Kamm RD, Drazen JM. Mechanical stress is communicated between different cell types to elicit matrix remodeling. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6180-5.
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Huang C, De Sanctis GT, O'Brien PJ, Mizgerd JP, Friend DS, Drazen JM, Brass LF, Stevens RL. Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. J Biol Chem. 2001 Jul 13; 276(28):26276-84.
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Wang Z, Chen C, Niu T, Wu D, Yang J, Wang B, Fang Z, Yandava CN, Drazen JM, Weiss ST, Xu X. Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking. Am J Respir Crit Care Med. 2001 May; 163(6):1404-9.
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Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, Israel E, Kraft M, Lemanske RF, Martin RJ, McLean D, Peters SP, Sorkness C, Szefler SJ. Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. Am J Respir Crit Care Med. 2001 May; 163(6):1470-5.
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Lemanske RF, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman SA, Peters SP, Spahn JD, Szefler SJ. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA. 2001 May 23-30; 285(20):2594-603.
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Lazarus SC, Boushey HA, Fahy JV, Chinchilli VM, Lemanske RF, Sorkness CA, Kraft M, Fish JE, Peters SP, Craig T, Drazen JM, Ford JG, Israel E, Martin RJ, Mauger EA, Nachman SA, Spahn JD, Szefler SJ. Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA. 2001 May 23-30; 285(20):2583-93.
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Leone FT, Mauger EA, Peters SP, Chinchilli VM, Fish JE, Boushey HA, Cherniack RM, Drazen JM, Fahy JV, Ford J, Israel E, Lazarus SC, Lemanske RF, Martin RJ, McGeady SJ, Sorkness C, Szefler SJ. The utility of peak flow, symptom scores, and beta-agonist use as outcome measures in asthma clinical research. Chest. 2001 Apr; 119(4):1027-33.
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Antman K, Lagakos S, Drazen J. Designing and funding clinical trials of novel therapies. N Engl J Med. 2001 Mar 8; 344(10):762-3.
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Epstein AM, Drazen JM, Steinbrook R. Health policy 2001--a new series. N Engl J Med. 2001 Mar 1; 344(9):673.
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Moy ML, Israel E, Weiss ST, Juniper EF, Dubé L, Drazen JM. Clinical predictors of health-related quality of life depend on asthma severity. Am J Respir Crit Care Med. 2001 Mar; 163(4):924-9.
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Silverman ES, De Sanctis GT, Boyce J, Maclean JA, Jiao A, Green FH, Grasemann H, Faunce D, Fitzmaurice G, Shi GP, Stein-Streilein J, Milbrandt J, Collins T, Drazen JM. The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):778-85.
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Silverman ES, Liggett SB, Gelfand EW, Rosenwasser LJ, Baron RM, Bolk S, Weiss ST, Drazen JM. The pharmacogenetics of asthma: a candidate gene approach. Pharmacogenomics J. 2001; 1(1):27-37.
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Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol. 2001 Jan-Mar; 124(1-3):183-6.
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Wechsler ME, Grasemann H, Deykin A, Silverman EK, Yandava CN, Israel E, Wand M, Drazen JM. Exhaled nitric oxide in patients with asthma: association with NOS1 genotype. Am J Respir Crit Care Med. 2000 Dec; 162(6):2043-7.
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Moore PE, Laporte JD, Abraham JH, Schwartzman IN, Yandava CN, Silverman ES, Drazen JM, Wand MP, Panettieri RA, Shore SA. Polymorphism of the beta(2)-adrenergic receptor gene and desensitization in human airway smooth muscle. Am J Respir Crit Care Med. 2000 Dec; 162(6):2117-24.
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Grasemann H, Knauer N, Büscher R, Hübner K, Drazen JM, Ratjen F. Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene. Am J Respir Crit Care Med. 2000 Dec; 162(6):2172-6.
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Silverman EK, Weiss ST, Drazen JM, Chapman HA, Carey V, Campbell EJ, Denish P, Silverman RA, Celedon JC, Reilly JJ, Ginns LC, Speizer FE. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 Dec; 162(6):2152-8.
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MacLean JA, De Sanctis GT, Ackerman KG, Drazen JM, Sauty A, DeHaan E, Green FH, Charo IF, Luster AD. CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness. J Immunol. 2000 Dec 1; 165(11):6568-75.
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Drazen JM, Koski G. To protect those who serve. N Engl J Med. 2000 Nov 30; 343(22):1643-5.
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Campion EW, Curfman GD, Drazen JM. Tracking the peer-review process. N Engl J Med. 2000 Nov 16; 343(20):1485-6.
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Drazen JM, Bush GW, Gore A. The Republican and Democratic candidates speak on health care. N Engl J Med. 2000 Oct 19; 343(16):1184-9.
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Harel Z, Lilly C, Riggs S, Vaz R, Drazen J. Urinary leukotriene (LT) E(4) in adolescents with dysmenorrhea: a pilot study. J Adolesc Health. 2000 Sep; 27(3):151-4.
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Taylor DR, Drazen JM, Herbison GP, Yandava CN, Hancox RJ, Town GI. Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism. Thorax. 2000 Sep; 55(9):762-7.
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Drazen JM. Looking forward to serving you every week. N Engl J Med. 2000 Jul 6; 343(1):57-8.
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Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med. 2000 Jul; 162(1):75-80.
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Van Sambeek R, Stevenson DD, Baldasaro M, Lam BK, Zhao J, Yoshida S, Yandora C, Drazen JM, Penrose JF. 5' flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. J Allergy Clin Immunol. 2000 Jul; 106(1 Pt 1):72-6.
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Grasemann H, Yandava CN, Storm van's Gravesande K, Deykin A, Pillari A, Ma J, Sonna LA, Lilly C, Stampfer MJ, Israel E, Silverman EK, Drazen JM. A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma. Biochem Biophys Res Commun. 2000 Jun 7; 272(2):391-4.
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Ressler B, Lee RT, Randell SH, Drazen JM, Kamm RD. Molecular responses of rat tracheal epithelial cells to transmembrane pressure. Am J Physiol Lung Cell Mol Physiol. 2000 Jun; 278(6):L1264-72.
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Dellaripa PF, Wechsler ME, Roth ME, Drazen J. Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents. Mayo Clin Proc. 2000 Jun; 75(6):643-5.
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Silverman EK, Speizer FE, Weiss ST, Chapman HA, Schuette A, Campbell EJ, Reilly JJ, Ginns LC, Drazen JM. Familial aggregation of severe, early-onset COPD : candidate gene approaches Chest. 2000 May; 117(5 Suppl 1):273S-4S.
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Deykin A, Massaro AF, Coulston E, Drazen JM, Israel E. Exhaled nitric oxide following repeated spirometry or repeated plethysmography in healthy individuals. Am J Respir Crit Care Med. 2000 Apr; 161(4 Pt 1):1237-40.
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Wechsler ME, Finn D, Gunawardena D, Westlake R, Barker A, Haranath SP, Pauwels RA, Kips JC, Drazen JM. Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest. 2000 Mar; 117(3):708-13.
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Silverman ES, Drazen JM. Genetic variations in the 5-lipoxygenase core promoter. Description and functional implications. Am J Respir Crit Care Med. 2000 Feb; 161(2 Pt 2):S77-80.
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Drazen JM, Silverman EK, Lee TH. Heterogeneity of therapeutic responses in asthma. Br Med Bull. 2000; 56(4):1054-70.
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Nakamura H, Weiss ST, Israel E, Luster AD, Drazen JM, Lilly CM. Eotaxin and impaired lung function in asthma. Am J Respir Crit Care Med. 1999 Dec; 160(6):1952-6.
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Grasemann H, Yandava CN, Drazen JM. Neuronal NO synthase (NOS1) is a major candidate gene for asthma. Clin Exp Allergy. 1999 Dec; 29 Suppl 4:39-41.
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De Sanctis GT, Singer JB, Jiao A, Yandava CN, Lee YH, Haynes TC, Lander ES, Beier DR, Drazen JM. Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. Am J Physiol. 1999 Dec; 277(6 Pt 1):L1118-23.
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Silverman ES, Drazen JM. The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms. Proc Assoc Am Physicians. 1999 Nov-Dec; 111(6):525-36.
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Drazen JM. Asthma therapy with agents preventing leukotriene synthesis or action. Proc Assoc Am Physicians. 1999 Nov-Dec; 111(6):547-59.
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Celedon JC, Speizer FE, Drazen JM, Weiss ST, Campbell EJ, Carey VJ, Reilly JJ, Ginns L, Silverman EK. Bronchodilator responsiveness and serum total IgE levels in families of probands with severe early-onset COPD. Eur Respir J. 1999 Nov; 14(5):1009-14.
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Wechsler ME, Pauwels R, Drazen JM. Leukotriene modifiers and Churg-Strauss syndrome: adverse effect or response to corticosteroid withdrawal? Drug Saf. 1999 Oct; 21(4):241-51.
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Yandava CN, Pillari A, Drazen JM. Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. Genomics. 1999 Oct 1; 61(1):108-11.
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Lilly CM, Woodruff PG, Camargo CA, Nakamura H, Drazen JM, Nadel ES, Hanrahan JP. Elevated plasma eotaxin levels in patients with acute asthma. J Allergy Clin Immunol. 1999 Oct; 104(4 Pt 1):786-90.
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Burchard EG, Silverman EK, Rosenwasser LJ, Borish L, Yandava C, Pillari A, Weiss ST, Hasday J, Lilly CM, Ford JG, Drazen JM. Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma. Am J Respir Crit Care Med. 1999 Sep; 160(3):919-22.
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Wechsler ME, Drazen JM. Zafirlukast and Churg-Strauss syndrome. Chest. 1999 Jul; 116(1):266-7.
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Wechsler M, Drazen JM. Churg-Strauss syndrome. Lancet. 1999 Jun 5; 353(9168):1970-1.
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Drazen JM, Takebayashi T, Long NC, De Sanctis GT, Shore SA. Animal models of asthma and chronic bronchitis. Clin Exp Allergy. 1999 Jun; 29 Suppl 2:37-47.
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Grasemann H, Drazen JM, Deykin A, Israel E, De Sanctis GT, Pillari A, Yandava CH. Simple tandem repeat polymorphisms in the neuronal nitric oxide synthase gene in different ethnic populations. Hum Hered. 1999 Jun; 49(3):139-41.
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Drazen JM, Yandava CN, Dubé L, Szczerback N, Hippensteel R, Pillari A, Israel E, Schork N, Silverman ES, Katz DA, Drajesk J. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet. 1999 Jun; 22(2):168-70.
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De Sanctis GT, MacLean JA, Hamada K, Mehta S, Scott JA, Jiao A, Yandava CN, Kobzik L, Wolyniec WW, Fabian AJ, Venugopal CS, Grasemann H, Huang PL, Drazen JM. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med. 1999 May 17; 189(10):1621-30.
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In KH, Silverman ES, Asano K, Beier D, Fischer AR, Keith TP, Serino K, Yandava C, De Sanctis GT, Drazen JM. Mutations in the human 5-lipoxygenase gene. Clin Rev Allergy Immunol. 1999 Spring-Summer; 17(1-2):59-69.
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MacLean JA, Sauty A, Luster AD, Drazen JM, De Sanctis GT. Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. Am J Respir Cell Mol Biol. 1999 Mar; 20(3):379-87.
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Yandava CN, Kennedy BP, Pillari A, Duncan AM, Drazen JM. Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12. Genomics. 1999 Feb 15; 56(1):131-3.
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De Sanctis GT, MacLean JA, Qin S, Wolyniec WW, Grasemann H, Yandava CN, Jiao A, Noonan T, Stein-Streilein J, Green FH, Drazen JM. Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. J Clin Invest. 1999 Feb; 103(4):507-15.
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Drazen JM, Silverman ES. Genetic determinants of 5-lipoxygenase transcription. Int Arch Allergy Immunol. 1999 Feb-Apr; 118(2-4):275-8.
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Drazen JM, Israel E, O'Byrne PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med. 1999 Jan 21; 340(3):197-206.
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Drazen JM, Finn PW, De Sanctis GT. Mouse models of airway responsiveness: physiological basis of observed outcomes and analysis of selected examples using these outcome indicators. Annu Rev Physiol. 1999; 61:593-625.
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Noviski N, Brewer JP, Skornik WA, Galli SJ, Drazen JM, Martin TR. Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice. J Appl Physiol. 1999 Jan; 86(1):202-10.
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Drazen JM, Israel E. Should antileukotriene therapies be used instead of inhaled corticosteroids in asthma? Yes. Am J Respir Crit Care Med. 1998 Dec; 158(6):1697-8.
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Silverman ES, Du J, Williams AJ, Wadgaonkar R, Drazen JM, Collins T. cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1). Biochem J. 1998 Nov 15; 336 ( Pt 1):183-9.
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Mehta S, Boudreau J, Lilly CM, Drazen JM. Endogenous pulmonary nitric oxide in the regulation of airway microvascular leak. Am J Physiol. 1998 Nov; 275(5 Pt 1):L961-8.
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Silverman E, In KH, Yandava C, Drazen JM. Pharmacogenetics of the 5-lipoxygenase pathway in asthma. Clin Exp Allergy. 1998 Nov; 28 Suppl 5:164-70; discussion 171-3.
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Drazen JM. Leukotrienes as mediators of airway obstruction. Am J Respir Crit Care Med. 1998 Nov; 158(5 Pt 3):S193-200.
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Haley KJ, Sunday ME, Wiggs BR, Kozakewich HP, Reilly JJ, Mentzer SJ, Sugarbaker DJ, Doerschuk CM, Drazen JM. Inflammatory cell distribution within and along asthmatic airways. Am J Respir Crit Care Med. 1998 Aug; 158(2):565-72.
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Silverman ES, Du J, De Sanctis GT, Rådmark O, Samuelsson B, Drazen JM, Collins T. Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants. Am J Respir Cell Mol Biol. 1998 Aug; 19(2):316-23.
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Ruddy MK, Drazen JM, Pitkanen OM, Rafii B, O'Brodovich HM, Harris HW. Modulation of aquaporin 4 and the amiloride-inhibitable sodium channel in perinatal rat lung epithelial cells. Am J Physiol. 1998 Jun; 274(6 Pt 1):L1066-72.
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Wolyniec WW, De Sanctis GT, Nabozny G, Torcellini C, Haynes N, Joetham A, Gelfand EW, Drazen JM, Noonan TC. Reduction of antigen-induced airway hyperreactivity and eosinophilia in ICAM-1-deficient mice. Am J Respir Cell Mol Biol. 1998 Jun; 18(6):777-85.
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Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O'DONNELL WJ, Reilly JJ, Ginns L, Mentzer S, Wain J, Speizer FE. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med. 1998 Jun; 157(6 Pt 1):1770-8.
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Drazen J. Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors. Am J Respir Crit Care Med. 1998 Jun; 157(6 Pt 2):S233-7; discussion S247-8.
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Deykin A, Halpern O, Massaro AF, Drazen JM, Israel E. Expired nitric oxide after bronchoprovocation and repeated spirometry in patients with asthma. Am J Respir Crit Care Med. 1998 Mar; 157(3 Pt 1):769-75.
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Drazen JM. New directions in asthma drug therapy. Hosp Pract (Minneap). 1998 Feb 15; 33(2):25-6, 31-3, 36-8.
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Wechsler ME, Garpestad E, Flier SR, Kocher O, Weiland DA, Polito AJ, Klinek MM, Bigby TD, Wong GA, Helmers RA, Drazen JM. Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. JAMA. 1998 Feb 11; 279(6):455-7.
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Haley KJ, Drazen JM. Inflammation and airway function in asthma: what you see is not necessarily what you get. Am J Respir Crit Care Med. 1998 Jan; 157(1):1-3.
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Wiggs BR, Hrousis CA, Drazen JM, Kamm RD. On the mechanism of mucosal folding in normal and asthmatic airways. J Appl Physiol. 1997 Dec; 83(6):1814-21.
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Drazen JM, Beier DR. The genetics of air pollution. Nat Genet. 1997 Dec; 17(4):365-6.
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De Sanctis GT, Mehta S, Kobzik L, Yandava C, Jiao A, Huang PL, Drazen JM. Contribution of type I NOS to expired gas NO and bronchial responsiveness in mice. Am J Physiol. 1997 Oct; 273(4 Pt 1):L883-8.
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Drazen JM, Silverman EK. Genetics of asthma: conference summary. Am J Respir Crit Care Med. 1997 Oct; 156(4 Pt 2):S69-71.
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De Sanctis GT, Drazen JM. Genetics of native airway responsiveness in mice. Am J Respir Crit Care Med. 1997 Oct; 156(4 Pt 2):S82-8.
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Fish JE, Peters SP, Chambers CV, McGeady SJ, Epstein KR, Boushey HA, Cherniack RM, Chinchilli VM, Drazen JM, Fahy JV, Hurd SS, Israel E, Lazarus SC, Lemanske RF, Martin RJ, Mauger EA, Sorkness C, Szefler SJ. An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Am J Respir Crit Care Med. 1997 Oct; 156(4 Pt 1):1165-71.
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O'Byrne PM, Israel E, Drazen JM. Antileukotrienes in the treatment of asthma. Ann Intern Med. 1997 Sep 15; 127(6):472-80.
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Mehta S, Drazen JM, Lilly CM. Endogenous nitric oxide and allergic bronchial hyperresponsiveness in guinea pigs. Am J Physiol. 1997 Sep; 273(3 Pt 1):L656-62.
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De Sanctis GT, Wolyniec WW, Green FH, Qin S, Jiao A, Finn PW, Noonan T, Joetham AA, Gelfand E, Doerschuk CM, Drazen JM. Reduction of allergic airway responses in P-selectin-deficient mice. J Appl Physiol. 1997 Sep; 83(3):681-7.
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De Sanctis GT, Itoh A, Green FH, Qin S, Kimura T, Grobholz JK, Martin TR, Maki T, Drazen JM. T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. Nat Med. 1997 Apr; 3(4):460-2.
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Lilly CM, Nakamura H, Kesselman H, Nagler-Anderson C, Asano K, Garcia-Zepeda EA, Rothenberg ME, Drazen JM, Luster AD. Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids. J Clin Invest. 1997 Apr 1; 99(7):1767-73.
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Haley KJ, Drazen JM, Osathanondh R, Sunday ME. Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung. Microsc Res Tech. 1997 Apr 1; 37(1):62-8.
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Serhan CN, Drazen JM. Antiinflammatory potential of lipoxygenase-derived eicosanoids: a molecular switch at 5 and 15 positions? J Clin Invest. 1997 Mar 15; 99(6):1147-8.
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Asano K, Nakamura H, Lilly CM, Klagsbrun M, Drazen JM. Interferon gamma induces prostaglandin G/H synthase-2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells. J Clin Invest. 1997 Mar 1; 99(5):1057-63.
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In KH, Asano K, Beier D, Grobholz J, Finn PW, Silverman EK, Silverman ES, Collins T, Fischer AR, Keith TP, Serino K, Kim SW, De Sanctis GT, Yandava C, Pillari A, Rubin P, Kemp J, Israel E, Busse W, Ledford D, Murray JJ, Segal A, Tinkleman D, Drazen JM. Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. J Clin Invest. 1997 Mar 1; 99(5):1130-7.
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Mehta S, Lilly CM, Rollenhagen JE, Haley KJ, Asano K, Drazen JM. Acute and chronic effects of allergic airway inflammation on pulmonary nitric oxide production. Am J Physiol. 1997 Jan; 272(1 Pt 1):L124-31.
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Sobh JF, Lilly CM, Drazen JM, Jackson AC. Respiratory transfer impedance between 8 and 384 Hz in guinea pigs before and after bronchial challenge. J Appl Physiol. 1997 Jan; 82(1):172-81.
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De Sanctis GT, Drazen JM. Genetics of airway responsiveness in the inbred mouse. Res Immunol. 1997 Jan; 148(1):73-9; discussion 79-83.
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Drazen JM. Pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors in the management of asthma. Pharmacotherapy. 1997 Jan-Feb; 17(1 Pt 2):22S-30S.
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Grasemann H, Drazen JM, Yandava CN. Protein sequence of the human neuronal nitric oxide synthase (Type I NOS): an error in the sequence database. Nitric Oxide. 1997; 1(6):441.
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Levy BD, Drazen JM, Serhan CN. Agonist-induced lipoxin A4 generation in vitro and in aspirin-sensitive asthmatics: detection by a novel lipoxin A4-ELISA. Adv Exp Med Biol. 1997; 400B:611-5.
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Drazen JM, Weiss ST, Cooper D. Beta 2 adrenoceptor polymorphisms. Thorax. 1996 Nov; 51(11):1168.
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Roach JM, Muza SR, Rock PB, Lyons TP, Lilly CM, Drazen JM, Cymerman A. Urinary leukotriene E4 levels increase upon exposure to hypobaric hypoxia. Chest. 1996 Oct; 110(4):946-51.
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Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med. 1996 Sep 19; 335(12):841-7.
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Asano K, Lilly CM, Drazen JM. Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells. Am J Physiol. 1996 Jul; 271(1 Pt 1):L126-31.
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Massaro AF, Drazen JM. "Exhaled nitric oxide during exercise: site of release and modulation by ventilation and blood flow". J Appl Physiol. 1996 Jun; 80(6):1863-4.
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Kamada AK, Szefler SJ, Martin RJ, Boushey HA, Chinchilli VM, Drazen JM, Fish JE, Israel E, Lazarus SC, Lemanske RF. Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network. Am J Respir Crit Care Med. 1996 Jun; 153(6 Pt 1):1739-48.
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Mansour M, Karmilowicz M, Hawrylik SJ, Nalcerio B, Angilly J, Conklyn MJ, Lilly CM, Drazen JM, Lee SE, Auperin DD, De Wet JR, Cohan VL, Showell HJ, Danley DE. Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells. Am J Physiol. 1996 Jun; 270(6 Pt 1):L1002-7.
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Massaro AF, Mehta S, Lilly CM, Kobzik L, Reilly JJ, Drazen JM. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am J Respir Crit Care Med. 1996 May; 153(5):1510-4.
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Yager D, Martins MA, Feldman H, Kamm RD, Drazen JM. Acute histamine-induced flux of airway liquid: role of neuropeptides. J Appl Physiol. 1996 Apr; 80(4):1285-95.
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Israel E, Cohn J, Dubé L, Drazen JM. Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. JAMA. 1996 Mar 27; 275(12):931-6.
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Lilly CM, Chapman RW, Sehring SJ, Mauser PJ, Egan RW, Drazen JM. Effects of interleukin 5-induced pulmonary eosinophilia on airway reactivity in the guinea pig. Am J Physiol. 1996 Mar; 270(3 Pt 1):L368-75.
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Drazen JM, Arm JP, Austen KF. Sorting out the cytokines of asthma. J Exp Med. 1996 Jan 1; 183(1):1-5.
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Asano K, Lilly CM, O'Donnell WJ, Israel E, Fischer A, Ransil BJ, Drazen JM. Diurnal variation of urinary leukotriene E4 and histamine excretion rates in normal subjects and patients with mild-to-moderate asthma. J Allergy Clin Immunol. 1995 Nov; 96(5 Pt 1):643-51.
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De Sanctis GT, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, Lander ES, Drazen JM. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet. 1995 Oct; 11(2):150-4.
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Fischer AR, McFadden CA, Frantz R, Awni WM, Cohn J, Drazen JM, Israel E. Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects. Am J Respir Crit Care Med. 1995 Oct; 152(4 Pt 1):1203-7.
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Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, Drazen JM. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med. 1995 Aug; 152(2):800-3.
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Drazen JM, Turino GM. Progress at the interface of inflammation and asthma. Report of an ATS-sponsored workshop November, 1993. Am J Respir Crit Care Med. 1995 Jul; 152(1):386-7.
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Drazen JM, Evans JF, Stevens RL, Shipp MA. Inflammatory effector mechanisms in asthma. Am J Respir Crit Care Med. 1995 Jul; 152(1):403-7.
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Drazen JM, Israel E. Treatment of chronic stable asthma with drugs active on the 5-lipoxygenase pathway. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):319-20.
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Lilly CM, Hall AE, Rodger IW, Kobzik L, Haley KJ, Drazen JM. Substance P-induced histamine release in tracheally perfused guinea pig lungs. J Appl Physiol. 1995 Apr; 78(4):1234-41.
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Yager D, Kamm RD, Drazen JM. Airway wall liquid. Sources and role as an amplifier of bronchoconstriction. Chest. 1995 Mar; 107(3 Suppl):105S-110S.
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Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med. 1995 Mar 1; 181(3):1211-6.
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Lilly CM, Bai TR, Shore SA, Hall AE, Drazen JM. Neuropeptide content of lungs from asthmatic and nonasthmatic patients. Am J Respir Crit Care Med. 1995 Feb; 151(2 Pt 1):548-53.
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Drazen J. Clinical studies with agents active on the 5-lipoxygenase pathway. Allergy. 1995; 50(22 Suppl):22-6.
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Drazen JM, Gaston B, Shore SA. Chemical regulation of pulmonary airway tone. Annu Rev Physiol. 1995; 57:151-70.
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Coleman RA, Eglen RM, Jones RL, Narumiya S, Shimizu T, Smith WL, Dahlén SE, Drazen JM, Gardiner PJ, Jackson WT, et al. Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature. Adv Prostaglandin Thromboxane Leukot Res. 1995; 23:283-5.
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Fischer AR, Rosenberg MA, Lilly CM, Callery JC, Rubin P, Cohn J, White MV, Igarashi Y, Kaliner MA, Drazen JM, et al. Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive asthma. J Allergy Clin Immunol. 1994 Dec; 94(6 Pt 1):1046-56.
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Yager D, Cloutier T, Feldman H, Bastacky J, Drazen JM, Kamm RD. Airway surface liquid thickness as a function of lung volume in small airways of the guinea pig. J Appl Physiol. 1994 Nov; 77(5):2333-40.
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Goodman DE, Israel E, Rosenberg M, Johnston R, Weiss ST, Drazen JM. The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med. 1994 Nov; 150(5 Pt 1):1256-61.
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Asano K, Chee CB, Gaston B, Lilly CM, Gerard C, Drazen JM, Stamler JS. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):10089-93.
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Israel E, Drazen JM. Treating mild asthma--when are inhaled steroids indicated? N Engl J Med. 1994 Sep 15; 331(11):737-9.
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Oettgen HC, Martin TR, Wynshaw-Boris A, Deng C, Drazen JM, Leder P. Active anaphylaxis in IgE-deficient mice. Nature. 1994 Aug 4; 370(6488):367-70.
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Lilly CM, Kobzik L, Hall AE, Drazen JM. Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs. J Clin Invest. 1994 Jun; 93(6):2667-74.
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Lilly CM, Besson G, Israel E, Rodger IW, Drazen JM. Capsaicin-induced airway obstruction in tracheally perfused guinea pig lungs. Am J Respir Crit Care Med. 1994 May; 149(5):1175-9.
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Vasconcellos CA, Allen PG, Wohl ME, Drazen JM, Janmey PA, Stossel TP. Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. Science. 1994 Feb 18; 263(5149):969-71.
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Gaston B, Drazen JM, Jansen A, Sugarbaker DA, Loscalzo J, Richards W, Stamler JS. Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro. J Pharmacol Exp Ther. 1994 Feb; 268(2):978-84.
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Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med. 1994 Feb; 149(2 Pt 1):538-51.
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Drazen JM, Lilly CM, Sperling R, Rubin P, Israel E. Role of cysteinyl leukotrienes in spontaneous asthmatic responses. Adv Prostaglandin Thromboxane Leukot Res. 1994; 22:251-62.
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Martin TR, Cohen ML, Drazen JM. Serotonin-induced pulmonary responses are mediated by the 5-HT2 receptor in the mouse. J Pharmacol Exp Ther. 1994 Jan; 268(1):104-9.
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Levy BD, Bertram S, Tai HH, Israel E, Fischer A, Drazen JM, Serhan CN. Agonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA. Lipids. 1993 Dec; 28(12):1047-53.
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Israel E, Rubin P, Kemp JP, Grossman J, Pierson W, Siegel SC, Tinkelman D, Murray JJ, Busse W, Segal AT, Fish J, Kaiser HB, Ledford D, Wenzel S, Rosenthal R, Cohn J, Lanni C, Pearlman H, Karahalios P, Drazen JM. The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma. Ann Intern Med. 1993 Dec 1; 119(11):1059-66.
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Israel E, Fischer AR, Rosenberg MA, Lilly CM, Callery JC, Shapiro J, Cohn J, Rubin P, Drazen JM. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am Rev Respir Dis. 1993 Dec; 148(6 Pt 1):1447-51.
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Gaston B, Reilly J, Drazen JM, Fackler J, Ramdev P, Arnelle D, Mullins ME, Sugarbaker DJ, Chee C, Singel DJ, et al. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci U S A. 1993 Dec 1; 90(23):10957-61.
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Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, Stamler JS. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol. 1993 Oct; 9(4):371-7.
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Lilly CM, Stamler JS, Gaston B, Meckel C, Loscalzo J, Drazen JM. Modulation of vasoactive intestinal peptide pulmonary relaxation by NO in tracheally superfused guinea pig lungs. Am J Physiol. 1993 Oct; 265(4 Pt 1):L410-5.
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Lilly CM, Drazen JM, Shore SA. Peptidase modulation of airway effects of neuropeptides. Proc Soc Exp Biol Med. 1993 Sep; 203(4):388-404.
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Levy BD, Romano M, Chapman HA, Reilly JJ, Drazen J, Serhan CN. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. J Clin Invest. 1993 Sep; 92(3):1572-9.
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Shore SA, Martins MA, Drazen JM. Pulmonary mechanical responses to intravenously administered capsaicin in guinea-pigs: effect of peptidase inhibitors. Pulm Pharmacol. 1993 Sep; 6(3):193-9.
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Wetmore LA, Gerard C, Drazen JM. Human lung expresses unique gamma-glutamyl transpeptidase transcripts. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7461-5.
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Martin TR, Ando A, Takeishi T, Katona IM, Drazen JM, Galli SJ. Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice. J Immunol. 1993 Jul 1; 151(1):367-76.
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Shore SA, Sharpless C, Drazen JM. Bronchoconstrictor activities of NP gamma and NPK in anaesthetized guinea-pigs: effect on NEP inhibition. Pulm Pharmacol. 1993 Jun; 6(2):143-7.
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Gavriely N, Solway J, Elad D, Shabtai-Musih Y, Gaver DP, Grotberg JB, Drazen JM. Construction and uses of a concentric catheter for gas sampling in lung airways. J Appl Physiol. 1993 Jun; 74(6):3063-7.
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King KA, Hua J, Torday JS, Drazen JM, Graham SA, Shipp MA, Sunday ME. CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. J Clin Invest. 1993 May; 91(5):1969-73.
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Martin TR, Takeishi T, Katz HR, Austen KF, Drazen JM, Galli SJ. Mast cell activation enhances airway responsiveness to methacholine in the mouse. J Clin Invest. 1993 Mar; 91(3):1176-82.
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Lilly CM, Martins MA, Drazen JM. Peptidase modulation of vasoactive intestinal peptide pulmonary relaxation in tracheal superfused guinea pig lungs. J Clin Invest. 1993 Jan; 91(1):235-43.
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O'Donnell WJ, Rosenberg M, Niven RW, Drazen JM, Israel E. Acetazolamide and furosemide attenuate asthma induced by hyperventilation of cold, dry air. Am Rev Respir Dis. 1992 Dec; 146(6):1518-23.
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Shore SA, Martins MA, Drazen JM. Effect of the NEP inhibitor SCH32615 on airway responses to intravenous substance P in guinea pigs. J Appl Physiol. 1992 Nov; 73(5):1847-53.
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Molfino NA, Slutsky AS, Hoffstein V, McClean PA, Rebuck AS, Drazen JM, Zamel N. Changes in cross-sectional airway areas induced by methacholine, histamine, and LTC4 in asthmatic subjects. Am Rev Respir Dis. 1992 Sep; 146(3):577-80.
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Dupuy PM, Shore SA, Drazen JM, Frostell C, Hill WA, Zapol WM. Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest. 1992 Aug; 90(2):421-8.
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Drazen JM, O'Brien J, Sparrow D, Weiss ST, Martins MA, Israel E, Fanta CH. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis. 1992 Jul; 146(1):104-8.
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Kamm RD, Drazen JM. Airway hyperresponsiveness and airway wall thickening in asthma. A quantitative approach. Am Rev Respir Dis. 1992 Jun; 145(6):1249-50.
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Iijima H, Gerard NP, Squassoni C, Ewig J, Face D, Drazen JM, Kim YA, Shriver B, Hersh LB, Gerard C. Exon 16 del: a novel form of human neutral endopeptidase (CALLA). Am J Physiol. 1992 Jun; 262(6 Pt 1):L725-9.
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Jansen A, Drazen J, Osborne JA, Brown R, Loscalzo J, Stamler JS. The relaxant properties in guinea pig airways of S-nitrosothiols. J Pharmacol Exp Ther. 1992 Apr; 261(1):154-60.
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Martins MA, Shore SA, Drazen JM. Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs. Am J Physiol. 1991 Dec; 261(6 Pt 1):L449-55.
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Drazen JM, Israel E. Asthma: a solution to half the puzzle? Am Rev Respir Dis. 1991 Oct; 144(4):743-4.
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Wetmore LA, Gerard NP, Herron DK, Bollinger NG, Baker SR, Feldman HA, Drazen JM. Leukotriene receptor on U-937 cells: discriminatory responses to leukotrienes C4 and D4. Am J Physiol. 1991 Aug; 261(2 Pt 1):L164-71.
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Shore SA, Drazen JM. Relative bronchoconstrictor activity of neurokinin A and neurokinin A fragments in guinea pigs. J Appl Physiol. 1991 Aug; 71(2):452-7.
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Martins MA, Shore SA, Drazen JM. Capsaicin-induced release of tachykinins: effects of enzyme inhibitors. J Appl Physiol. 1991 May; 70(5):1950-6.
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Yager D, Shore S, Drazen JM. Airway luminal liquid. Sources and role as an amplifier of bronchoconstriction. Am Rev Respir Dis. 1991 Mar; 143(3 Pt 2):S52-4.
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Martins MA, Shore SA, Drazen JM. Tachykinin recovery during postmortem bronchoconstriction in guinea pig lungs. J Appl Physiol. 1991 Mar; 70(3):1215-9.
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Yager D, Martins MA, Shore SA, Drazen JM. Role of capsaicin-sensitive neurons in histamine-induced luminal liquid in small airways. Clin Exp Allergy. 1991 Jan; 21 Suppl 1:37-41.
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Martins MA, Shore SA, Drazen JM. Peptidase modulation of the pulmonary effects of tachykinins. Int Arch Allergy Appl Immunol. 1991; 94(1-4):325-9.
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Israel E, Dermarkarian R, Rosenberg M, Sperling R, Taylor G, Rubin P, Drazen JM. The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N Engl J Med. 1990 Dec 20; 323(25):1740-4.
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Koshino T, Bhaskar KR, Reid LM, Gerard C, Warner A, Shore SA, Anderson K, Butler G, Iijima H, Drazen JM. Recovery of an epitope recognized by a novel monoclonal antibody from airway lavage during experimental induction of chronic bronchitis. Am J Respir Cell Mol Biol. 1990 May; 2(5):453-62.
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Wanner A, Abraham WM, Douglas JS, Drazen JM, Richerson HB, Ram JS. NHLBI Workshop Summary. Models of airway hyperresponsiveness. Am Rev Respir Dis. 1990 Jan; 141(1):253-7.
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Martins MA, Shore SA, Gerard NP, Gerard C, Drazen JM. Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs. J Clin Invest. 1990 Jan; 85(1):170-6.
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Ingenito EP, Pichurko BM, Lafleur J, Drazen JM, Ingram RH, Solway J. Breathing pattern affects respiratory heat loss but not bronchoconstrictor response in asthma. Lung. 1990; 168(1):23-34.
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Shore SA, Drazen JM. Degradative enzymes modulate airway responses to intravenous neurokinins A and B. J Appl Physiol. 1989 Dec; 67(6):2504-11.
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Israel E, Juniper EF, Callaghan JT, Mathur PN, Morris MM, Dowell AR, Enas GG, Hargreave FE, Drazen JM. Effect of a leukotriene antagonist, LY171883, on cold air-induced bronchoconstriction in asthmatics. Am Rev Respir Dis. 1989 Nov; 140(5):1348-53.
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Ludwig MS, Bellofiore S, Shore SA, Drazen JM, Fredberg JJ. Dynamics of the collateral pathways of canine lungs after flow interruption. J Appl Physiol. 1989 Sep; 67(3):1213-9.
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Pichurko BM, Ingram RH, Sperling RI, Lafleur JE, Corey EJ, Austen KF, Drazen JM. Localization of the site of the bronchoconstrictor effects of leukotriene C4 compared with that of histamine in asthmatic subjects. Am Rev Respir Dis. 1989 Aug; 140(2):334-9.
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Drazen JM, Gerard C. Reversing the irreversible. N Engl J Med. 1989 Jun 8; 320(23):1555-6.
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Yager D, Butler JP, Bastacky J, Israel E, Smith G, Drazen JM. Amplification of airway constriction due to liquid filling of airway interstices. J Appl Physiol. 1989 Jun; 66(6):2873-84.
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Martin TR, Galli SJ, Katona IM, Drazen JM. Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. J Clin Invest. 1989 Apr; 83(4):1375-83.
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Drazen JM, Shore SA, Gerard NP. Substance P-induced effects in guinea pig lungs: effects of thiorphan and captopril. J Appl Physiol. 1989 Mar; 66(3):1364-72.
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Ray DW, Hernandez C, Leff AR, Drazen JM, Solway J. Tachykinins mediate bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs. J Appl Physiol. 1989 Mar; 66(3):1108-12.
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Shore SA, Drazen JM. Enhanced airway responses to substance P after repeated challenge in guinea pigs. J Appl Physiol. 1989 Feb; 66(2):955-61.
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Gerard NP, Hodges MK, Drazen JM, Weller PF, Gerard C. Characterization of a receptor for C5a anaphylatoxin on human eosinophils. J Biol Chem. 1989 Jan 25; 264(3):1760-6.
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Drazen JM, Shore SA, Gerard NP. Enzymatic degradation of neuropeptides: a possible mechanism of airway hyperresponsiveness. Prog Clin Biol Res. 1989; 297:45-55; discussion 55-6.
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Gerard C, Bhaskar KR, Gerard NP, Drazen JM, Reid L. Studies on the peptide core of human bronchial mucus glycoprotein. Symp Soc Exp Biol. 1989; 43:221-30.
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Venugopalan CS, Jenkins HJ, Drazen JM. The functional conversion hypothesis: a contributor to exercise-induced asthma? Med Hypotheses. 1988 Dec; 27(4):295-301.
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Kariya ST, Shore SA, Skornik WA, Anderson K, Ingram RH, Drazen JM. Methacholine-induced bronchoconstriction in dogs: effects of lung volume and O3 exposure. J Appl Physiol. 1988 Dec; 65(6):2679-86.
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Hodges MK, Weller PF, Gerard NP, Ackerman SJ, Drazen JM. Heterogeneity of leukotriene C4 production by eosinophils from asthmatic and from normal subjects. Am Rev Respir Dis. 1988 Oct; 138(4):799-804.
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Ludwig MS, Shore SA, Fredberg JJ, Drazen JM. Differential responses of tissue viscance and collateral resistance to histamine and leukotriene C4. J Appl Physiol. 1988 Sep; 65(3):1424-9.
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Ingenito E, Solway J, Lafleur J, Lombardo A, Drazen JM, Pichurko B. Dissociation of temperature-gradient and evaporative heat loss during cold gas hyperventilation in cold-induced asthma. Am Rev Respir Dis. 1988 Sep; 138(3):540-6.
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Martin TR, Gerard NP, Galli SJ, Drazen JM. Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol. 1988 Jun; 64(6):2318-23.
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Ludwig MS, Shore SA, Anderson K, Drazen JM. Temporal and regional variability of collateral resistance response to histamine. J Appl Physiol. 1988 May; 64(5):2142-9.
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Watson JW, Drazen JM, Stimler-Gerard NP. Synergism between inflammatory mediators in vivo. Induction of airway hyperresponsiveness to C3a in the guinea pig. Am Rev Respir Dis. 1988 Mar; 137(3):636-40.
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Shore SA, Stimler-Gerard NP, Coats SR, Drazen JM. Substance P-induced bronchoconstriction in the guinea pig. Enhancement by inhibitors of neutral metalloendopeptidase and angiotensin-converting enzyme. Am Rev Respir Dis. 1988 Feb; 137(2):331-6.
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Bhaskar KR, Drazen JM, O'Sullivan DD, Scanlon PM, Reid LM. Transition from normal to hypersecretory bronchial mucus in a canine model of bronchitis: changes in yield and composition. Exp Lung Res. 1988; 14(1):101-20.
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Drazen JM. Comparative contractile responses to sulfidopeptide leukotrienes in normal and asthmatic human subjects. Ann N Y Acad Sci. 1988; 524:289-97.
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Shore SA, Drazen JM. Airway responses to substance P and substance P fragments in the guinea pig. Pulm Pharmacol. 1988; 1(3):113-8.
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Shore SA, Stimler-Gerard NP, Smith E, Drazen JM. A formyl peptide contracts guinea pig lung: role of arachidonic acid metabolites. J Appl Physiol. 1987 Dec; 63(6):2450-9.
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Ingenito EP, Solway J, McFadden ER, Pichurko B, Bowman HF, Michaels D, Drazen JM. Indirect assessment of mucosal surface temperatures in the airways: theory and tests. J Appl Physiol. 1987 Nov; 63(5):2075-83.
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Israel E, Robin JL, Drazen JM. Differential effects of calcium channel blockers on leukotriene C4- and D4-induced contractions in guinea pig pulmonary parenchymal strips. J Pharmacol Exp Ther. 1987 Nov; 243(2):424-9.
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Drazen JM, Austen KF. Leukotrienes and airway responses. Am Rev Respir Dis. 1987 Oct; 136(4):985-98.
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Drazen JM, Boushey HA, Holgate ST, Kaliner M, O'Byrne P, Valentine M, Widdicombe JH, Woolcock A. The pathogenesis of severe asthma: a consensus report from the Workshop on Pathogenesis. J Allergy Clin Immunol. 1987 Sep; 80(3 Pt 2):428-37.
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Fanta CH, Watson JW, Lacouture PG, Drazen JM. In vivo bronchodilator activity of nifedipine in the guinea pig. Am Rev Respir Dis. 1987 Jul; 136(1):76-9.
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Davidson AB, Hirshman CA, Downes H, Drazen JM. Large-volume ventilation results in bronchoconstriction of Basenji-Greyhound dogs. J Appl Physiol. 1987 Jun; 62(6):2308-13.
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Solway J, Fredberg JJ, Ingram RH, Pedersen OF, Drazen JM. Interdependent regional lung emptying during forced expiration: a transistor model. J Appl Physiol. 1987 May; 62(5):2013-25.
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Butler JP, Lehr JL, Drazen JM. Longitudinal elastic wave propagation in pulmonary parenchyma. J Appl Physiol. 1987 Apr; 62(4):1349-55.
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Scanlon PD, Seltzer J, Ingram RH, Reid L, Drazen JM. Chronic exposure to sulfur dioxide. Physiologic and histologic evaluation of dogs exposed to 50 or 15 ppm. Am Rev Respir Dis. 1987 Apr; 135(4):831-9.
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Shore SA, Kariya ST, Anderson K, Skornik W, Feldman HA, Pennington J, Godleski J, Drazen JM. Sulfur-dioxide-induced bronchitis in dogs. Effects on airway responsiveness to inhaled and intravenously administered methacholine. Am Rev Respir Dis. 1987 Apr; 135(4):840-7.
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Davidson AB, Lee TH, Scanlon PD, Solway J, McFadden ER, Ingram RH, Corey EJ, Austen KF, Drazen JM. Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects. Am Rev Respir Dis. 1987 Feb; 135(2):333-7.
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Schwartzstein RM, Kelleher M, Weinberger SE, Weiss JW, Drazen JM. Airway effects of monosodium glutamate in subjects with chronic stable asthma. J Asthma. 1987; 24(3):167-72.
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Ingenito EP, Solway J, McFadden ER, Pichurko BM, Cravalho EG, Drazen JM. Finite difference analysis of respiratory heat transfer. J Appl Physiol. 1986 Dec; 61(6):2252-9.
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Drazen JM, Dreshaij I, Ingram RH, Khoo M, Kamm R, Solway J. CO2 elimination by high-frequency oscillation: effects of vagosympathetic stimulation. J Appl Physiol. 1986 Nov; 61(5):1836-42.
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Solway J, Leff AR, Dreshaj I, Munoz NM, Ingenito EP, Michaels D, Ingram RH, Drazen JM. Circulatory heat sources for canine respiratory heat exchange. J Clin Invest. 1986 Oct; 78(4):1015-9.
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Berdine GG, Lehr JL, McKinley DS, Drazen JM. Nonuniformity of canine lung washout by high-frequency ventilation. J Appl Physiol. 1986 Oct; 61(4):1388-94.
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Rossing TH, Drazen JM. Effects of milrinone on contractile responses of guinea pig trachea, lung parenchyma and pulmonary artery. J Pharmacol Exp Ther. 1986 Sep; 238(3):874-9.
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Venugopalan CS, Jenkins HJ, Drazen JM. Effect of temperature on beta receptor responsiveness in guinea pig pulmonary tissues. Res Commun Chem Pathol Pharmacol. 1986 Sep; 53(3):275-88.
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Watson JW, Jackson AC, Drazen JM. Effect of lung volume on pulmonary mechanics in guinea pigs. J Appl Physiol. 1986 Jul; 61(1):304-11.
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Solway J, Rossing TH, Saari AF, Drazen JM. Expiratory flow limitation and dynamic pulmonary hyperinflation during high-frequency ventilation. J Appl Physiol. 1986 Jun; 60(6):2071-8.
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Davidson AB, Seltzer J, Ingram RH, Drazen JM. Effect of tidal volume and anesthetic agent on airway responsiveness to histamine. J Appl Physiol. 1986 May; 60(5):1765-71.
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Lee TH, Israel E, Drazen JM, Leitch AG, Ravalese J, Corey EJ, Robinson DR, Lewis RA, Austen KF. Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet. J Immunol. 1986 Apr 1; 136(7):2575-82.
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Castile RG, Pedersen OF, Drazen JM, Ingram RH. Density dependence of maximal expiratory flow before and during tracheal constriction in dogs. J Appl Physiol. 1986 Mar; 60(3):1060-6.
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Drazen JM. Inhalation challenge with sulfidopeptide leukotrienes in human subjects. Chest. 1986 Mar; 89(3):414-9.
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Lee TH, Austen KF, Leitch AG, Israel E, Robinson DR, Lewis RA, Corey EJ, Drazen JM. The effects of a fish-oil-enriched diet on pulmonary mechanics during anaphylaxis. Am Rev Respir Dis. 1985 Dec; 132(6):1204-9.
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Solway J, Pichurko BM, Ingenito EP, McFadden ER, Fanta CH, Ingram RH, Drazen JM. Breathing pattern affects airway wall temperature during cold air hyperpnea in humans. Am Rev Respir Dis. 1985 Oct; 132(4):853-7.
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Israel E, Shore S, Drazen JM. Leukotrienes and immediate hypersensitivity responses. Ann Inst Pasteur Immunol. 1985 Sep-Oct; 136D(2):216-9.
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Lehr JL, Butler JP, Westerman PA, Zatz SL, Drazen JM. Photographic measurement of pleural surface motion during lung oscillation. J Appl Physiol. 1985 Aug; 59(2):623-33.
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Gavriely N, Solway J, Loring SH, Butler JP, Slutsky AS, Drazen JM. Pressure-flow relationships of endotracheal tubes during high-frequency ventilation. J Appl Physiol. 1985 Jul; 59(1):3-11.
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Fredberg JJ, Ingram RH, Castile RG, Glass GM, Drazen JM. Nonhomogeneity of lung response to inhaled histamine assessed with alveolar capsules. J Appl Physiol. 1985 Jun; 58(6):1914-22.
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Solway J, Gavriely N, Slutsky AS, Rossing TH, Drinker P, Saari AF, Drazen JM. Effect of bias flow rate on gas transport during high-frequency oscillatory ventilation. Respir Physiol. 1985 May; 60(2):267-76.
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Gavriely N, Solway J, Drazen JM, Slutsky AS, Brown R, Loring SH, Ingram RH. Radiographic visualization of airway wall movement during oscillatory flow in dogs. J Appl Physiol. 1985 Feb; 58(2):645-52.
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Bhaskar KR, O'Sullivan DD, Seltzer J, Rossing TH, Drazen JM, Reid LM. Density gradient study of bronchial mucus aspirates from healthy volunteers (smokers and nonsmokers) and from patients with tracheostomy. Exp Lung Res. 1985; 9(3-4):289-308.
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Lee TH, Drazen JM, Lewis RA, Austen KF. Substrate and regulatory functions of eicosapentaenoic and docosahexaenoic acids for the 5-lipoxygenase pathway. Implications for pulmonary responses. Prog Biochem Pharmacol. 1985; 20:1-17.
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Gordon T, Venugopalan CS, Amdur MO, Drazen JM. Ozone-induced airway hyperreactivity in the guinea pig. J Appl Physiol. 1984 Oct; 57(4):1034-8.
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Khoo MC, Slutsky AS, Drazen JM, Solway J, Gavriely N, Kamm RD. Gas mixing during high-frequency ventilation: an improved model. J Appl Physiol. 1984 Aug; 57(2):493-506.
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Lee TH, Austen KF, Corey EJ, Drazen JM. Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4922-5.
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Drazen JM. Physiological basis and interpretation of indices of pulmonary mechanics. Environ Health Perspect. 1984 Jun; 56:3-9.
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Leitch AG, Lee TH, Ringel EW, Prickett JD, Robinson DR, Pyne SG, Corey EJ, Drazen JM, Austen KF, Lewis RA. Immunologically induced generation of tetraene and pentaene leukotrienes in the peritoneal cavities of menhaden-fed rats. J Immunol. 1984 May; 132(5):2559-65.
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Venugopalan CS, Said SI, Drazen JM. Effect of vasoactive intestinal peptide on vagally mediated tracheal pouch relaxation. Respir Physiol. 1984 May; 56(2):205-16.
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Seltzer J, Scanlon PD, Drazen JM, Ingram RH, Reid L. Morphologic correlation of physiologic changes caused by SO2-induced bronchitis in dogs. The role of inflammation. Am Rev Respir Dis. 1984 May; 129(5):790-7.
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Drazen JM, Kamm RD, Slutsky AS. High-frequency ventilation. Physiol Rev. 1984 Apr; 64(2):505-43.
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Saari AF, Rossing TH, Solway J, Drazen JM. Lung inflation during high-frequency ventilation. Am Rev Respir Dis. 1984 Feb; 129(2):333-6.
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Solway J, Gavriely N, Kamm RD, Drazen JM, Ingram RH, Khoo MC, Brown R, Slutsky AS. Intra-airway gas mixing during high-frequency ventilation. J Appl Physiol. 1984 Feb; 56(2):343-54.
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Saari AF, Rossing TH, Drazen JM. Physiological bases for new approaches to mechanical ventilation. Annu Rev Med. 1984; 35:165-74.
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Rossing TH, Solway J, Saari AF, Gavriely N, Slutsky AS, Lehr JL, Drazen JM. Influence of the endotracheal tube on CO2 transport during high-frequency ventilation. Am Rev Respir Dis. 1984 Jan; 129(1):54-7.
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Kamm RD, Stutsky AS, Drazen JM. High-frequency ventilation. Crit Rev Biomed Eng. 1984; 9(4):347-79.
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Drazen JM, Lacouture PG, Miller MJ. Inhibition by propranolol of the contractile response of the rat diaphragm to tetanic field stimulation in vitro. Br J Pharmacol. 1983 Dec; 80(4):613-8.
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Leitch AG, Corey EJ, Austen KF, Drazen JM. Indomethacin potentiates the pulmonary response to aerosol leukotriene C4 in the guinea pig. Am Rev Respir Dis. 1983 Oct; 128(4):639-43.
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Austen KF, Corey EJ, Drazen JM, Leitch AG. The effect of indomethacin on the contractile response of the guinea-pig lung parenchymal strip to leukotrienes B4, C4, D4 and E4. Br J Pharmacol. 1983 Sep; 80(1):47-53.
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Castile RG, Pedersen OF, Drazen JM, Ingram RH. Density dependence of maximal flow in dogs with central and peripheral obstruction. J Appl Physiol. 1983 Sep; 55(3):717-25.
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Leitch AG, Austen KF, Corey EJ, Drazen JM. Effects of indomethacin on the guinea-pig pulmonary response to intravenous leukotrienes C4 and D4. Clin Sci (Lond). 1983 Sep; 65(3):281-7.
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Fanta CH, Drazen JM. Calcium blockers and bronchoconstriction. Am Rev Respir Dis. 1983 Jun; 127(6):673-4.
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Weiss JW, Drazen JM, McFadden ER, Weller P, Corey EJ, Lewis RA, Austen KF. Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. JAMA. 1983 May 27; 249(20):2814-7.
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Drazen JM, Fanta CH, Lacouture PG. Effect of nifedipine on constriction of human tracheal strips in vitro. Br J Pharmacol. 1983 Apr; 78(4):687-91.
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Griffin M, Weiss JW, Leitch AG, McFadden ER, Corey EJ, Austen KF, Drazen JM. Effects of leukotriene D on the airways in asthma. N Engl J Med. 1983 Feb 24; 308(8):436-9.
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Slutsky AS, Kamm RD, Drazen JM. High frequency oscillatory ventilation using tidal volumes smaller than the anatomical dead space. Int Anesthesiol Clin. 1983; 21(3):161-81.
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Lewis RA, Lee CW, Levine L, Morgan RA, Weiss JW, Drazen JM, Oh H, Hoover D, Corey EJ, Austen KF. Biology of the C-6-sulfidopeptide leukotrienes. Adv Prostaglandin Thromboxane Leukot Res. 1983; 11:15-26.
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Rossing TH, Slutsky AS, Ingram RH, Kamm RD, Shapiro AH, Drazen JM. CO2 elimination by high-frequency oscillations in dogs--effects of histamine infusion. J Appl Physiol. 1982 Nov; 53(5):1256-62.
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Pedersen OF, Castile RG, Drazen JM, Ingram RH. Density dependence of maximum expiratory flow in the dog. J Appl Physiol. 1982 Aug; 53(2):397-404.
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Drazen JM, O'Cain CF, Ingram RH. Experimental induction of chronic bronchitis in dogs: effects on airway obstruction and responsiveness. Am Rev Respir Dis. 1982 Jul; 126(1):75-9.
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Weiss JW, Drazen JM, Coles N, McFadden ER, Weller PF, Corey EJ, Lewis RA, Austen KF. Bronchoconstrictor effects of leukotriene C in humans. Science. 1982 Apr 9; 216(4542):196-8.
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Drazen JM, Venugopalan CS, Austen KF, Brion F, Corey EJ. Effects of leukotriene E on pulmonary mechanics in the guinea pig. Am Rev Respir Dis. 1982 Mar; 125(3):290-4.
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Fanta CH, Venugopalan CS, Lacouture PG, Drazen JM. Inhibition of bronchoconstriction in the guinea pig by a calcium channel blocker, nifedipine. Am Rev Respir Dis. 1982 Jan; 125(1):61-6.
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Weiss JW, Drazen JM, McFadden ER, Weller PF, Corey EJ, Lewis RA, Austen KF. Comparative bronchoconstrictor effects of histamine, leukotriene C, and leukotriene D in normal human volunteers. Trans Assoc Am Physicians. 1982; 95:30-5.
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Lewis RA, Drazen JM, Figueiredo JC, Corey EJ, Austen KF. A review of recent contributions on biologically active products of arachidonate conversion. Int J Immunopharmacol. 1982; 4(2):85-90.
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Lewis RA, Austen KF, Drazen JM, Soter NA, Figueiredo JC, Corey EJ. Structure, function, and metabolism of leukotriene constituents of SRS-A. Adv Prostaglandin Thromboxane Leukot Res. 1982; 9:137-51.
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Rossing TH, Slutsky AS, Lehr JL, Drinker PA, Kamm R, Drazen JM. Tidal volume and frequency dependence of carbon dioxide elimination by high-frequency ventilation. N Engl J Med. 1981 Dec 3; 305(23):1375-9.
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Slutsky AS, Kamm RD, Rossing TH, Loring SH, Lehr J, Shapiro AH, Ingram RH, Drazen JM. Effects of frequency, tidal volume, and lung volume on CO2 elimination in dogs by high frequency (2-30 Hz), low tidal volume ventilation. J Clin Invest. 1981 Dec; 68(6):1475-84.
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Loring SH, Ingram RH, Drazen JM. Effects of lung inflation on airway and tissue responses to aerosol histamine. J Appl Physiol. 1981 Oct; 51(4):806-11.
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Lewis RA, Goetzl EJ, Drazen JM, Soter NA, Austen KF, Corey EJ. Functional characterization of synthetic leukotriene B and its stereochemical isomers. J Exp Med. 1981 Oct 1; 154(4):1243-8.
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Slutsky AS, Drazen JM, O'Cain CF, Ingram RH. Alveolar pressure-airflow characteristics in humans breathing air, He-O2, and SF6-O2. J Appl Physiol. 1981 Oct; 51(4):1033-7.
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Yanta MA, Snapper JR, Ingram RH, Drazen JM, Coles S, Reid L. Airway responsiveness to inhaled mediators: relationship to epithelial thickness and secretory cell number. Am Rev Respir Dis. 1981 Sep; 124(3):337-40.
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Loring SH, Drazen JM, Smith JC, Hoppin FG. Vagal stimulation and aerosol histamine increase hysteresis of lung recoil. J Appl Physiol. 1981 Aug; 51(2):477-84.
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Lewis RA, Drazen JM, Austen KF, Toda M, Brion F, Marfat A, Corey EJ. Contractile activities of structural analogs of leukotrienes C and D: role of the polar substituents. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4579-83.
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Slutsky AS, Brown R, Lehr J, Rossing T, Drazen JM. High-frequency ventilation: a promising new approach to mechanical ventilation. Med Instrum. 1981 Jul-Aug; 15(4):229-33.
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Slutsky AS, Berdine GG, Drazen JM. Oscillatory flow and quasi-steady behavior in a model of human central airways. J Appl Physiol. 1981 Jun; 50(6):1293-9.
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Jackson AC, Loring SH, Drazen JM. Serial distribution of bronchoconstriction induced by vagal stimulation or histamine. J Appl Physiol. 1981 Jun; 50(6):1286-92.
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Drazen JM, Lewis RA, Austen KF, Toda M, Brion F, Marfat A, Corey EJ. Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region. Proc Natl Acad Sci U S A. 1981 May; 78(5):3195-8.
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Yanta MA, Loring SH, Ingram RH, Drazen JM. Direct and reflex bronchoconstriction induced by histamine aerosol inhalation in dogs. J Appl Physiol. 1981 Apr; 50(4):869-73.
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Goldstein D, Slutsky AS, Ingram RH, Westerman P, Venegas J, Drazen J. CO2 elimination by high frequency ventilation (4 to 10 Hz) in normal subjects. Am Rev Respir Dis. 1981 Mar; 123(3):251-5.
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Snapper JR, Braasch PS, Ingram RH, Loring SH, Drazen JM. Effects of beta adrenergic blockade on histamine and prostaglandin-F2 alpha responsiveness in the dog. J Allergy Clin Immunol. 1981 Mar; 67(3):199-205.
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Bach MK, Brashler JR, Johnson MA, Drazen JM. Slow-reacting substances from rat leukocytes: selective action on the airways, and progress toward elucidation of their structure. Kroc Found Ser. 1981; 14:37-50.
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Bach MK, Brashler JR, Johnson MA, Drazen JM. Two rat mononuclear cell-derived slow reacting substances: kinetic evidence that the peripheral airways-selective spasmogen is derived from a nonselectively acting precursor. Immunopharmacology. 1980 Dec; 2(4):361-73.
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Snapper JR, Braasch PS, Loring SH, Ingram RH, Drazen JM. Comparison of the responsiveness to histamine and to Ascaris suum challenge in dogs. Am Rev Respir Dis. 1980 Nov; 122(5):775-80.
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Lewis RA, Drazen JM, Austen KF, Clark DA, Corey EJ. Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity. Biochem Biophys Res Commun. 1980 Sep 16; 96(1):271-7.
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Slutsky AS, Berdine GG, Drazen JM. Steady flow in a model of human central airways. J Appl Physiol. 1980 Sep; 49(3):417-23.
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Drazen J. Histamine and nocturnal wheezing. N Engl J Med. 1980 Jul 31; 303(5):278-9.
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Snapper JR, Braasch PS, Ingram RH, Loring SH, Drazen JM. In vivo effect of cimetidine on canine pulmonary responsiveness to aerosol histamine. J Allergy Clin Immunol. 1980 Jul; 66(1):70-4.
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Drazen JM, Austen KF, Lewis RA, Clark DA, Goto G, Marfat A, Corey EJ. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):4354-8.
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Lewis RA, Austen KF, Drazen JM, Clark DA, Marfat A, Corey EJ. Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3710-4.
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Schneider MW, Drazen JM. Comparative in vitro effects of arachidonic acid metabolites on tracheal spirals and parenchymal strips. Am Rev Respir Dis. 1980 May; 121(5):835-42.
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Drazen JM, Venugopalan CS, Schneider MW. Alteration of histamine response by H2-receptor antagonism in the guinea pig. J Appl Physiol. 1980 Apr; 48(4):613-8.
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Chesrown SE, Venugopalan CS, Gold WM, Drazen JM. In vivo demonstration of nonadrenergic inhibitory innervation of the guinea pig trachea. J Clin Invest. 1980 Feb; 65(2):314-20.
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Slutsky AS, Drazen JM. Estimating central and peripheral respiratory resistance: an alternative analysis. J Appl Physiol. 1979 Dec; 47(6):1325-31.
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Drazen JM, Loring SH, Jackson AC, Snapper JR, Ingram RH. Effects of volume history on airway changes induced by histamine or vagal stimulation. J Appl Physiol. 1979 Oct; 47(4):657-65.
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Snapper JR, Drazen JM, Loring SH, Braasch PS, Ingram RH. Vagal effects on histamine, carbachol, and prostaglandin F2 alpha responsiveness in the dog. J Appl Physiol. 1979 Jul; 47(1):13-6.
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Drazen JM, Schneider MW, Venugopalan CS. Bronchodilator activity of dimaprit in the guinea pig in vitro and in vivo. Eur J Pharmacol. 1979 May 1; 55(3):233-9.
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Loring SH, Elliott EA, Drazen JM. Kinetic energy loss and convective acceleration in respiratory resistance measurements. Lung. 1979; 156(1):33-42.
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Drazen JM, Lewis RA, Wasserman SI, Orange RP, Austen KF. Differential effects of a partially purified preparation of slow-reacting substance of anaphylaxis on guinea pig tracheal spirals and parenchymal strips. J Clin Invest. 1979 Jan; 63(1):1-5.
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Drazen JM, Loring SH, Venugopalan C. Lung volumes after antigen infusion in the guinea pig in vivo: effects of vagal section. J Appl Physiol. 1978 Dec; 45(6):957-61.
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Ingram RH, Drazen JM. Effects of preferential deposition of histamine in the human airway. Am Rev Respir Dis. 1978 Aug; 118(2):445-6.
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Loring SH, Drazen JM, Snapper JR, Ingram RH. Vagal and aerosol histamine interactions on airway responses in dogs. J Appl Physiol. 1978 Jul; 45(1):40-4.
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Drazen JM, Schneider MW. Comparative responses of tracheal spirals and parenchymal strips to histamine and carbachol in vitro. J Clin Invest. 1978 Jun; 61(6):1441-7.
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Snapper JR, Drazen JM, Loring SH, Schneider W, Ingram RH. Distribution of pulmonary responsiveness to aerosol histamine in dogs. J Appl Physiol. 1978 May; 44(5):738-42.
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Drazen JM. Adrenergic influences on histamine-mediated bronchoconstriction in the guinea pig. J Appl Physiol. 1978 Mar; 44(3):340-5.
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Drazen JM, Venugopalan CS, Soter NA. H2 receptor mediated inhibition of immediate type hypersensitivity reactions in vivo. Am Rev Respir Dis. 1978 Mar; 117(3):479-84.
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Loring SH, Drazen JM, Ingram RH. Canine pulmonary response to aerosol histamine: direct versus vagal effects. J Appl Physiol. 1977 Jun; 42(6):946-52.
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Drazen JM, Loring SH, Ingram RH. Distribution of pulmonary resistance: effects of gas density, viscosity, and flow rate. J Appl Physiol. 1976 Sep; 41(3):388-95.
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Drazen JM, Loring SH, Ingram RH. Localization of airway constriction using gases of varying density and viscosity. J Appl Physiol. 1976 Sep; 41(3):396-9.
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Drazen JM. Physiologic basis and interpretation of common indices of respiratory mechanical function. Environ Health Perspect. 1976 Aug; 16:11-6.
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Drazen JM, Loring SH, Regan R. Validation of an automated determination of pulmonary resistance by electrical subtraction. J Appl Physiol. 1976 Jan; 40(1):110-13.
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Drazen JM, Austen KF. Pulmonary response to antigen infusion in the sensitized guinea pig: modification by atropine. J Appl Physiol. 1975 Dec; 39(6):916-9.
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Drazen JM, Austen KF. Atropine modification of the pulmonary effects of chemical mediators in the guinea pig. J Appl Physiol. 1975 May; 38(5):834-8.
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Drazen JM, Austen KF. Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2alpha on pulmonary mechanics in the guinea pig. J Clin Invest. 1974 Jun; 53(6):1679-85.
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Drazen JM, Stechschulte DJ, Austen KF. Antigen-antibody mediated desensitization of human lung fragments in vitro. J Allergy Clin Immunol. 1973 Sep; 52(3):158-66.
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Drazen JM, Herd JA. Cardiac output at rest in the squirrel monkey: role of -adrenergic activity. Am J Physiol. 1972 Apr; 222(4):988-93.
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