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Baojian Fan, Ph.D., M.D.

TitleInstructor in Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infirmary
Ophthalmology, Connector Building, #557
243 Charles St
Boston MA 02114
Phone617/573-6447
Fax617/573-6439

 Biography 
 awards and honors
1988 - 1993Excellent Undergraduate Student Awards
1994 - 1997Excellent Postgraduate Student Awards
2000 - Outstanding Poster Award
2001 - 2004Postgraduate Studentship
2002 - 2003Postgraduate Student Grants for Overseas Academic Activities
2004 - 2006Postdoctoral Fellowship
2005 - AFV Young Researcher of the Year
2005 - Contract-end Merit Award
2006 - 2007Postdoctoral Fellowship
2007 - 2011Senior Research Fellowship
2009 - Winner of the Poster Contest

 Overview 
 overview
Dr. Fan graduated in 2004 with a PhD degree, majoring in Molecular Genetics of Ophthalmology. He obtained a Master degree in Epidemiology & Biostatistics in 1997 and a Bachelor degree in Medicine (M.D. equivalent) in 1993.

His primary interests are gene mapping for complex diseases such as glaucoma using exome sequencing study, genome-wide association study, candidate gene association study, linkage study, and microarray gene expression study. He is also interested in analysis of gene-gene and gene-environment interactions in complex diseases.

His major achievements include: 1) identification of two new genetic loci on chromosome 5 (GLC1M) and 15 (GLC1N) for juvenile onset glaucoma; 2) findings of genetic interactions between glaucoma-associated genes (myocilin, optineurin and apolipoprotein E) which are highly appraised by the Faculty of 1000 Biology; 3) identification of a number of genes specifically changed in gene expression on human trabecular meshwork cells treated with dexamethasone and triamcinolone; 4) identification of a novel myocilin mutation which causes the mutant complexes remained sequestered intracellularly in COS-7 cells and is the genetic cause of a family affected with juvenile onset glaucoma; 5) demonstration of association of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma; 6) identification of a significant role of the promoter of lysyl oxidase-like 1 in exfoliation glaucoma; 7) demonstration of that genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma; 8) demonstration of that CDKN2BAS variants contribute to optic nerve disease in exfoliation glaucoma.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wiggs JL, Hewitt AW, Fan BJ, Wang DY, Figueiredo Sena DR, O'Brien C, Realini A, Craig JE, Dimasi DP, Mackey DA, Haines JL, Pasquale LR. The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma. PLoS One. 2012; 7(9):e45613.
    View in: PubMed
  2. Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, Abdrabou W, Fan BJ, Wang DY, Brodeur W, Budenz DL, Caprioli J, Crenshaw A, Crooks K, Delbono E, Doheny KF, Friedman DS, Gaasterland D, Gaasterland T, Laurie C, Lee RK, Lichter PR, Loomis S, Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi SE, Musch DC, Realini A, Rozsa FW, Schuman JS, Scott K, Singh K, Stein JD, Trager EH, Vanveldhuisen P, Vollrath D, Wollstein G, Yoneyama S, Zhang K, Weinreb RN, Ernst J, Kellis M, Masuda T, Zack D, Richards JE, Pericak-Vance M, Pasquale LR, Haines JL. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet. 2012; 8(4):e1002654.
    View in: PubMed
  3. Fan BJ, Pasquale LR, Rhee D, Li T, Haines JL, Wiggs JL. LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2372-8.
    View in: PubMed
  4. Fan BJ, Wang DY, Pasquale LR, Haines JL, Wiggs JL. Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1788-92.
    View in: PubMed
  5. Fan BJ, Pasquale LR. Copy number variations on chromosome 12q14 in patients with normal tension glaucoma. International Glaucoma Review. 2011; 13(2).
  6. Desronvil T, Logan-Wyatt D, Abdrabou W, Triana M, Jones R, Taheri S, Del Bono E, Pasquale LR, Olivier M, Haines JL, Fan BJ, Wiggs JL. Distribution of COL8A2 and COL8A1 gene variants in Caucasian primary open angle glaucoma patients with thin central corneal thickness. Mol Vis. 2010; 16:2185-91.
    View in: PubMed
  7. Fan BJ, Wiggs JL. Glaucoma: genes, phenotypes, and new directions for therapy. J Clin Invest. 2010 Sep; 120(9):3064-72.
    View in: PubMed
  8. Fan BJ, Figuieredo Sena DR, Pasquale LR, Grosskreutz CL, Rhee DJ, Chen TC, Delbono EA, Haines JL, Wiggs JL. Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma. J Glaucoma. 2010 Sep; 19(7):432-6.
    View in: PubMed
  9. Fan BJ, Liu K, Wang DY, Tham CC, Tam PO, Lam DS, Pang CP. Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4110-6.
    View in: PubMed
  10. Ng TK, Lam CY, Lam DS, Chiang SW, Tam PO, Wang DY, Fan BJ, Yam GH, Fan DS, Pang CP. AC and AG dinucleotide repeats in the PAX6 P1 promoter are associated with high myopia. Mol Vis. 2009; 15:2239-48.
    View in: PubMed
  11. Kang JH, Wiggs JL, Rosner BA, Hankinson SE, Abdrabou W, Fan BJ, Haines J, Pasquale LR. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):971-9.
    View in: PubMed
  12. Fan BJ, Wang DY, Cheng CY, Ko WC, Lam SC, Pang CP. Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucoma. Mol Vis. 2009; 15:646-53.
    View in: PubMed
  13. Fan BJ, Chen T, Grosskreutz C, Pasquale L, Rhee D, DelBono E, Haines JL, Wiggs JL. Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma. Mol Vis. 2008; 14:2484-91.
    View in: PubMed
  14. Li H, Louey JW, Choy KW, Liu DT, Chan WM, Chan YM, Fung NS, Fan BJ, Baum L, Chan JC, Lam DS, Pang CP. EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes. Mol Vis. 2008; 14:1698-704.
    View in: PubMed
  15. Fan BJ, Wang DY, Tham CC, Lam DS, Pang CP. Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone. Invest Ophthalmol Vis Sci. 2008 May; 49(5):1886-97.
    View in: PubMed
  16. Song YQ, Ho DW, Karppinen J, Kao PY, Fan BJ, Luk KD, Yip SP, Leong JC, Cheah KS, Sham P, Chan D, Cheung KM. Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese. BMC Med Genet. 2008; 9:38.
    View in: PubMed
  17. Lam CY, Tam PO, Fan DS, Fan BJ, Wang DY, Lee CW, Pang CP, Lam DS. A genome-wide scan maps a novel high myopia locus to 5p15. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):3768-78.
    View in: PubMed
  18. Fan BJ, Pasquale L, Grosskreutz CL, Rhee D, Chen T, DeAngelis MM, Kim I, del Bono E, Miller JW, Li T, Haines JL, Wiggs JL. DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity. BMC Med Genet. 2008; 9:5.
    View in: PubMed
  19. Wang DY, Fan BJ, Yam GY, Lam DS, Pang CP. The cytotoxic and stress responses of human trabecular meshwork cells treated with triamcinolone acetonide. Mol Vis. 2008; 14:105-13.
    View in: PubMed
  20. Fan BJ, Wiggs JL. DNA sequence variants in LOXL1 and pseudoexfoliation glaucoma. US Ophthalmic Review. 2008; 3:18-20.
  21. Fan BJ, Ko WC, Wang DY, Canlas O, Ritch R, Lam DS, Pang CP. Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene. Mol Vis. 2007; 13:779-84.
    View in: PubMed
  22. Wang DY, Fan BJ, Chua JK, Tam PO, Leung CK, Lam DS, Pang CP. A genome-wide scan maps a novel juvenile-onset primary open-angle glaucoma locus to 15q. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5315-21.
    View in: PubMed
  23. Lam CY, Fan BJ, Wang DY, Tam PO, Yung Tham CC, Leung DY, Ping Fan DS, Chiu Lam DS, Pang CP. Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population. J Glaucoma. 2006 Jun; 15(3):218-22.
    View in: PubMed
  24. Yao HY, Cheng CY, Fan BJ, Tam OS, Tham CY, Wang DY, Lam SC, Pang CP. [Polymorphisms of myocilin and optineurin in primary open angle glaucoma patients]. Zhonghua Yi Xue Za Zhi. 2006 Feb 28; 86(8):554-9.
    View in: PubMed
  25. Pang CP, Fan BJ, Canlas O, Wang DY, Dubois S, Tam PO, Lam DS, Raymond V, Ritch R. A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q. Mol Vis. 2006; 12:85-92.
    View in: PubMed
  26. Fan BJ, Tam PO, Choy KW, Wang DY, Lam DS, Pang CP. Molecular diagnostics of genetic eye diseases. Clin Biochem. 2006 Mar; 39(3):231-9.
    View in: PubMed
  27. Fan BJ, Leung DY, Wang DY, Gobeil S, Raymond V, Tam PO, Lam DS, Pang CP. Novel myocilin mutation in a Chinese family with juvenile-onset open-angle glaucoma. Arch Ophthalmol. 2006 Jan; 124(1):102-6.
    View in: PubMed
  28. Fan BJ, Wang DY, Lam DS, Pang CP. Gene mapping for primary open angle glaucoma. Clin Biochem. 2006 Mar; 39(3):249-58.
    View in: PubMed
  29. Fan BJ, Wang DY, Fan DS, Tam PO, Lam DS, Tham CC, Lam CY, Lau TC, Pang CP. SNPs and interaction analyses of myocilin, optineurin, and apolipoprotein E in primary open angle glaucoma patients. Mol Vis. 2005; 11:625-31.
    View in: PubMed
  30. Wang DY, Fan BJ, Chan WM, Tam OS, Chiang WY, Lam SC, Pang CP. [Digenic association of RHO and RP1 genes with retinitis pigmentosa among Chinese population in Hong Kong]. Zhonghua Yi Xue Za Zhi. 2005 Jun 22; 85(23):1613-7.
    View in: PubMed
  31. Wang DY, Fan BJ, Wu XQ, Chan WM, Lam SC, Pang CP. [Recent progress in molecular genetics and gene therapy for retinitis pigmentosa]. Zhonghua Yan Ke Za Zhi. 2005 Feb; 41(2):188-92.
    View in: PubMed
  32. Wang DY, Chan WM, Tam PO, Baum L, Lam DS, Chong KK, Fan BJ, Pang CP. Gene mutations in retinitis pigmentosa and their clinical implications. Clin Chim Acta. 2005 Jan; 351(1-2):5-16.
    View in: PubMed
  33. Wang DY, Fan BJ, Canlas O, Tam PO, Ritch R, Lam DS, Fan DS, Pang CP. Absence of myocilin and optineurin mutations in a large Philippine family with juvenile onset primary open angle glaucoma. Mol Vis. 2004 Nov 9; 10:851-6.
    View in: PubMed
  34. Fan BJ, Leung YF, Pang CP, Fan DS, Wang DY, Tong WC, Tam PO, Chua JK, Lau TC, Lam DS. Polymorphisms in the myocilin promoter unrelated to the risk and severity of primary open-angle glaucoma. J Glaucoma. 2004 Oct; 13(5):377-84.
    View in: PubMed
  35. Fan BJ, Leung YF, Wang N, Lam SC, Liu Y, Tam OS, Pang CP. Genetic and environmental risk factors for primary open-angle glaucoma. Chin Med J (Engl). 2004 May; 117(5):706-10.
    View in: PubMed
  36. Fan BJ, Leung YF, Pang CP, Baum L, Tam OS, Wang N, Lam SC. [Single nucleotide polymorphisms of the myocilin gene in primary open-angle glaucoma patients]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Feb; 21(1):70-3.
    View in: PubMed
  37. Leung YF, Tam PO, Lee WS, Lam DS, Yam HF, Fan BJ, Tham CC, Chua JK, Pang CP. The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells. Mol Vis. 2003 Sep 5; 9:425-39.
    View in: PubMed
  38. Leung YF, Fan BJ, Lam DS, Lee WS, Tam PO, Chua JK, Tham CC, Lai JS, Fan DS, Pang CP. Different optineurin mutation pattern in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2003 Sep; 44(9):3880-4.
    View in: PubMed
  39. Lam DS, Lee WS, Leung YF, Tam PO, Fan DS, Fan BJ, Pang CP. TGFbeta-induced factor: a candidate gene for high myopia. Invest Ophthalmol Vis Sci. 2003 Mar; 44(3):1012-5.
    View in: PubMed
  40. Fan BJ, Leung YF. Beginning microarray data analysis: A biologist's guide to analysis of DNA microarray data. J Cell Sci. 2003; 116:1649-50.
  41. Pang CP, Leung YF, Fan B, Baum L, Tong WC, Lee WS, Chua JK, Fan DS, Liu Y, Lam DS. TIGR/MYOC gene sequence alterations in individuals with and without primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2002 Oct; 43(10):3231-5.
    View in: PubMed
  42. Wang N, Peng Z, Fan B, Liu Y, Dong X, Liang X, Luan J. [Case control study on the risk factors of primary open angle glaucoma in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Aug; 23(4):293-6.
    View in: PubMed
  43. Fan B, Liang X, Peng Z, Dong X, Liu Y, Luan J, Wang N. [Study on single nucleotide polymorphism of TIGR gene in primary open-angle glaucoma patients]. Zhonghua Yi Xue Za Zhi. 2002 Jun 10; 82(11):743-7.
    View in: PubMed
  44. Lu Y, Chen DC, Li Q, Xuan GW, Fan BJ, Zhao JW, Wang N. [Antibacterial effect of niaoluqing oral liquid on clinical drug-resistant strains and different serotype strains of Ureaplasma urealyticum in vitro]. Zhonghua Nan Ke Xue. 2002; 8(2):152-4.
    View in: PubMed
  45. Yam HF, Pang CP, Fan DS, Fan BJ, Yu EY, Lam DS. Growth factor changes in ex vivo expansion of human limbal epithelial cells on human amniotic membrane. Cornea. 2002 Jan; 21(1):101-5.
    View in: PubMed
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