Baojian Fan, Ph.D., M.D.
|Title||Instructor in Ophthalmology|
|Institution||Massachusetts Eye and Ear Infirmary|
|Address||Massachusetts Eye & Ear Infirmary|
Ophthalmology, Connector Building, #557
243 Charles St
Boston MA 02114
1993||Excellent Undergraduate Student Awards |
1997||Excellent Postgraduate Student Awards |
||Outstanding Poster Award|
2003||Postgraduate Student Grants for Overseas Academic Activities|
||AFV Young Researcher of the Year|
||Contract-end Merit Award|
2011||Senior Research Fellowship|
||Winner of the Poster Contest|
Dr. Fan graduated in 2004 with a PhD degree, majoring in Molecular Genetics of Ophthalmology. He obtained a Master degree in Epidemiology & Biostatistics in 1997 and a Bachelor degree in Medicine (M.D. equivalent) in 1993.
His primary interests are gene mapping for complex diseases such as glaucoma using exome sequencing study, genome-wide association study, candidate gene association study, linkage study, and microarray gene expression study. He is also interested in analysis of gene-gene and gene-environment interactions in complex diseases.
His major achievements include: 1) identification of two new genetic loci on chromosome 5 (GLC1M) and 15 (GLC1N) for juvenile onset glaucoma; 2) findings of genetic interactions between glaucoma-associated genes (myocilin, optineurin and apolipoprotein E) which are highly appraised by the Faculty of 1000 Biology; 3) identification of a number of genes specifically changed in gene expression on human trabecular meshwork cells treated with dexamethasone and triamcinolone; 4) identification of a novel myocilin mutation which causes the mutant complexes remained sequestered intracellularly in COS-7 cells and is the genetic cause of a family affected with juvenile onset glaucoma; 5) demonstration of association of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma; 6) identification of a significant role of the promoter of lysyl oxidase-like 1 in exfoliation glaucoma; 7) demonstration of that genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma; 8) demonstration of that CDKN2BAS variants contribute to optic nerve disease in exfoliation glaucoma.
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