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Danesh Moazed, PH.D.

TitleProfessor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHMS, Department of Cell Biology
LHRRB Room 517
240 Longwood Ave
Boston MA 02115
Phone617/432-1258
Fax617/432-1144

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moazed D. A piRNA to remember. Cell. 2012 Apr 27; 149(3):512-4.
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  2. Holoch D, Moazed D. RNAi in fission yeast finds new targets and new ways of targeting at the nuclear periphery. Genes Dev. 2012 Apr 15; 26(8):741-5.
    View in: PubMed
  3. Moazed D. Mechanisms for the inheritance of chromatin states. Cell. 2011 Aug 19; 146(4):510-8.
    View in: PubMed
  4. Tung SY, Hong JY, Walz T, Moazed D, Liou GG. Chromatin affinity-precipitation using a small metabolic molecule: its application to analysis of O-acetyl-ADP-ribose. Cell Mol Life Sci. 2012 Feb; 69(4):641-50.
    View in: PubMed
  5. Gullerova M, Moazed D, Proudfoot NJ. Autoregulation of convergent RNAi genes in fission yeast. Genes Dev. 2011 Mar 15; 25(6):556-68.
    View in: PubMed
  6. Gerace EL, Moazed D. Histone demethylation and timely DNA replication. Mol Cell. 2010 Dec 10; 40(5):683-4.
    View in: PubMed
  7. Gerace EL, Halic M, Moazed D. The methyltransferase activity of Clr4Suv39h triggers RNAi independently of histone H3K9 methylation. Mol Cell. 2010 Aug 13; 39(3):360-72.
    View in: PubMed
  8. Mekhail K, Moazed D. The nuclear envelope in genome organization, expression and stability. Nat Rev Mol Cell Biol. 2010 May; 11(5):317-28.
    View in: PubMed
  9. Halic M, Moazed D. Dicer-independent primal RNAs trigger RNAi and heterochromatin formation. Cell. 2010 Feb 19; 140(4):504-16.
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  10. Moazed D. Molecular biology. Rejoice--RNAi for yeast. Science. 2009 Oct 23; 326(5952):533-4.
    View in: PubMed
  11. Halic M, Moazed D. 22G-RNAs in transposon silencing and centromere function. Mol Cell. 2009 Oct 23; 36(2):170-1.
    View in: PubMed
  12. Johnson A, Li G, Sikorski TW, Buratowski S, Woodcock CL, Moazed D. Reconstitution of heterochromatin-dependent transcriptional gene silencing. Mol Cell. 2009 Sep 24; 35(6):769-81.
    View in: PubMed
  13. Sinha M, Watanabe S, Johnson A, Moazed D, Peterson CL. Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling. Cell. 2009 Sep 18; 138(6):1109-21.
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  14. Halic M, Moazed D. Transposon silencing by piRNAs. Cell. 2009 Sep 18; 138(6):1058-60.
    View in: PubMed
  15. Li H, Motamedi MR, Yip CK, Wang Z, Walz T, Patel DJ, Moazed D. An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Mol Cell. 2009 Apr 24; 34(2):155-67.
    View in: PubMed
  16. Tomson BN, Rahal R, Reiser V, Monje-Casas F, Mekhail K, Moazed D, Amon A. Regulation of Spo12 phosphorylation and its essential role in the FEAR network. Curr Biol. 2009 Mar 24; 19(6):449-60.
    View in: PubMed
  17. Moazed D. Small RNAs in transcriptional gene silencing and genome defence. Nature. 2009 Jan 22; 457(7228):413-20.
    View in: PubMed
  18. Motamedi MR, Hong EJ, Li X, Gerber S, Denison C, Gygi S, Moazed D. HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol Cell. 2008 Dec 26; 32(6):778-90.
    View in: PubMed
  19. Mekhail K, Seebacher J, Gygi SP, Moazed D. Role for perinuclear chromosome tethering in maintenance of genome stability. Nature. 2008 Dec 4; 456(7222):667-70.
    View in: PubMed
  20. Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K. Epigenomics: a roadmap, but to where? Science. 2008 Oct 3; 322(5898):43-4.
    View in: PubMed
  21. Buchberger JR, Onishi M, Li G, Seebacher J, Rudner AD, Gygi SP, Moazed D. Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae. Mol Cell Biol. 2008 Nov; 28(22):6903-18.
    View in: PubMed
  22. Bühler M, Spies N, Bartel DP, Moazed D. TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway. Nat Struct Mol Biol. 2008 Oct; 15(10):1015-23.
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  23. Iida T, Nakayama J, Moazed D. siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription. Mol Cell. 2008 Jul 25; 31(2):178-89.
    View in: PubMed
  24. Kanfi Y, Shalman R, Peshti V, Pilosof SN, Gozlan YM, Pearson KJ, Lerrer B, Moazed D, Marine JC, de Cabo R, Cohen HY. Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett. 2008 Mar 5; 582(5):543-8.
    View in: PubMed
  25. Onishi M, Liou GG, Buchberger JR, Walz T, Moazed D. Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. Mol Cell. 2007 Dec 28; 28(6):1015-28.
    View in: PubMed
  26. Bühler M, Moazed D. Transcription and RNAi in heterochromatic gene silencing. Nat Struct Mol Biol. 2007 Nov; 14(11):1041-8.
    View in: PubMed
  27. Colmenares SU, Buker SM, Buhler M, Dlakic M, Moazed D. Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi. Mol Cell. 2007 Aug 3; 27(3):449-61.
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  28. Skiniotis G, Moazed D, Walz T. Acetylated histone tail peptides induce structural rearrangements in the RSC chromatin remodeling complex. J Biol Chem. 2007 Jul 20; 282(29):20804-8.
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  29. Niu H, Li X, Job E, Park C, Moazed D, Gygi SP, Hollingsworth NM. Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis. Mol Cell Biol. 2007 Aug; 27(15):5456-67.
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  30. Bühler M, Haas W, Gygi SP, Moazed D. RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing. Cell. 2007 May 18; 129(4):707-21.
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  31. Lan F, Zaratiegui M, Villén J, Vaughn MW, Verdel A, Huarte M, Shi Y, Gygi SP, Moazed D, Martienssen RA, Shi Y. S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol Cell. 2007 Apr 13; 26(1):89-101.
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  32. Buker SM, Iida T, Bühler M, Villén J, Gygi SP, Nakayama J, Moazed D. Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast. Nat Struct Mol Biol. 2007 Mar; 14(3):200-7.
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  33. Morris CA, Moazed D. Centromere assembly and propagation. Cell. 2007 Feb 23; 128(4):647-50.
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  34. Huang J, Brito IL, Villén J, Gygi SP, Amon A, Moazed D. Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev. 2006 Oct 15; 20(20):2887-901.
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  35. Matecic M, Martins-Taylor K, Hickman M, Tanny J, Moazed D, Holmes SG. New alleles of SIR2 define cell-cycle-specific silencing functions. Genetics. 2006 Aug; 173(4):1939-50.
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  36. Bühler M, Verdel A, Moazed D. Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing. Cell. 2006 Jun 2; 125(5):873-86.
    View in: PubMed
  37. Huang J, Moazed D. Sister chromatid cohesion in silent chromatin: each sister to her own ring. Genes Dev. 2006 Jan 15; 20(2):132-7.
    View in: PubMed
  38. Moazed D, Bühler M, Buker SM, Colmenares SU, Gerace EL, Gerber SA, Hong EJ, Motamedi MR, Verdel A, Villén J, Gygi SP. Studies on the mechanism of RNAi-dependent heterochromatin assembly. Cold Spring Harb Symp Quant Biol. 2006; 71:461-71.
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  39. Verdel A, Moazed D. RNAi-directed assembly of heterochromatin in fission yeast. FEBS Lett. 2005 Oct 31; 579(26):5872-8.
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  40. Hong EJ, Villén J, Gerace EL, Gygi SP, Moazed D. A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation. RNA Biol. 2005 Jul-Sep; 2(3):106-11.
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  41. Buratowski S, Moazed D. Gene regulation: expression and silencing coupled. Nature. 2005 Jun 30; 435(7046):1174-5.
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  42. Rudner AD, Hall BE, Ellenberger T, Moazed D. A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin. Mol Cell Biol. 2005 Jun; 25(11):4514-28.
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  43. Liou GG, Tanny JC, Kruger RG, Walz T, Moazed D. Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. Cell. 2005 May 20; 121(4):515-27.
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  44. Verdel A, Moazed D. Labeling and characterization of small RNAs associated with the RNA interference effector complex RITS. Methods Enzymol. 2005; 392:297-307.
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  45. Sugiyama T, Cam H, Verdel A, Moazed D, Grewal SI. RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc Natl Acad Sci U S A. 2005 Jan 4; 102(1):152-7.
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  46. Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP, Moazed D. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell. 2004 Dec 17; 119(6):789-802.
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  47. Denison C, Rudner AD, Gerber SA, Bakalarski CE, Moazed D, Gygi SP. A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics. 2005 Mar; 4(3):246-54.
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  48. Noma K, Sugiyama T, Cam H, Verdel A, Zofall M, Jia S, Moazed D, Grewal SI. RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet. 2004 Nov; 36(11):1174-80.
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  49. Tanny JC, Kirkpatrick DS, Gerber SA, Gygi SP, Moazed D. Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions. Mol Cell Biol. 2004 Aug; 24(16):6931-46.
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  50. Stegmeier F, Huang J, Rahal R, Zmolik J, Moazed D, Amon A. The replication fork block protein Fob1 functions as a negative regulator of the FEAR network. Curr Biol. 2004 Mar 23; 14(6):467-80.
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  51. Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D. RNAi-mediated targeting of heterochromatin by the RITS complex. Science. 2004 Jan 30; 303(5658):672-6.
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  52. Moazed D, Rudner AD, Huang J, Hoppe GJ, Tanny JC. A model for step-wise assembly of heterochromatin in yeast. Novartis Found Symp. 2004; 259:48-56; discussion 56-62, 163-9.
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  53. Huang J, Moazed D. Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev. 2003 Sep 1; 17(17):2162-76.
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  54. Grewal SI, Moazed D. Heterochromatin and epigenetic control of gene expression. Science. 2003 Aug 8; 301(5634):798-802.
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  55. Shankaranarayana GD, Motamedi MR, Moazed D, Grewal SI. Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast. Curr Biol. 2003 Jul 15; 13(14):1240-6.
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  56. Chang JF, Hall BE, Tanny JC, Moazed D, Filman D, Ellenberger T. Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3. Structure. 2003 Jun; 11(6):637-49.
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  57. Li J, Moazed D, Gygi SP. Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation. J Biol Chem. 2002 Dec 20; 277(51):49383-8.
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  58. Tanny JC, Moazed D. Recognition of acetylated proteins: lessons from an ancient family of enzymes. Structure. 2002 Oct; 10(10):1290-2.
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  59. Hoppe GJ, Tanny JC, Rudner AD, Gerber SA, Danaie S, Gygi SP, Moazed D. Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol. 2002 Jun; 22(12):4167-80.
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  60. Kellogg DR, Moazed D. Protein- and immunoaffinity purification of multiprotein complexes. Methods Enzymol. 2002; 351:172-83.
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  61. Moazed D. Common themes in mechanisms of gene silencing. Mol Cell. 2001 Sep; 8(3):489-98.
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  62. Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem. 2001 Oct 19; 276(42):38837-43.
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  63. Shou W, Sakamoto KM, Keener J, Morimoto KW, Traverso EE, Azzam R, Hoppe GJ, Feldman RM, DeModena J, Moazed D, Charbonneau H, Nomura M, Deshaies RJ. Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol Cell. 2001 Jul; 8(1):45-55.
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  64. Moazed D. Enzymatic activities of Sir2 and chromatin silencing. Curr Opin Cell Biol. 2001 Apr; 13(2):232-8.
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  65. Tanny JC, Moazed D. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):415-20.
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  66. Tanny JC, Dowd GJ, Huang J, Hilz H, Moazed D. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell. 1999 Dec 23; 99(7):735-45.
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  67. Shou W, Seol JH, Shevchenko A, Baskerville C, Moazed D, Chen ZW, Jang J, Shevchenko A, Charbonneau H, Deshaies RJ. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell. 1999 Apr 16; 97(2):233-44.
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  68. Straight AF, Shou W, Dowd GJ, Turck CW, Deshaies RJ, Johnson AD, Moazed D. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell. 1999 Apr 16; 97(2):245-56.
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  69. Merryman C, Moazed D, McWhirter J, Noller HF. Nucleotides in 16S rRNA protected by the association of 30S and 50S ribosomal subunits. J Mol Biol. 1999 Jan 8; 285(1):97-105.
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  70. Merryman C, Moazed D, Daubresse G, Noller HF. Nucleotides in 23S rRNA protected by the association of 30S and 50S ribosomal subunits. J Mol Biol. 1999 Jan 8; 285(1):107-13.
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  71. Moazed D, Kistler A, Axelrod A, Rine J, Johnson AD. Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2186-91.
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  72. Moazed D, Johnson D. A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae. Cell. 1996 Aug 23; 86(4):667-77.
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  73. Moazed D, Samaha RR, Gualerzi C, Noller HF. Specific protection of 16 S rRNA by translational initiation factors. J Mol Biol. 1995 Apr 28; 248(2):207-10.
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  74. Moazed D, O'Farrell PH. Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development. 1992 Nov; 116(3):805-10.
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  75. Woodcock J, Moazed D, Cannon M, Davies J, Noller HF. Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA. EMBO J. 1991 Oct; 10(10):3099-103.
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  76. Moazed D, Noller HF. Sites of interaction of the CCA end of peptidyl-tRNA with 23S rRNA. Proc Natl Acad Sci U S A. 1991 May 1; 88(9):3725-8.
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  77. Moazed D, Noller HF. Binding of tRNA to the ribosomal A and P sites protects two distinct sets of nucleotides in 16 S rRNA. J Mol Biol. 1990 Jan 5; 211(1):135-45.
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  78. Moazed D, Noller HF. Intermediate states in the movement of transfer RNA in the ribosome. Nature. 1989 Nov 9; 342(6246):142-8.
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  79. Moazed D, Noller HF. Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites. Cell. 1989 May 19; 57(4):585-97.
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  80. De Stasio EA, Moazed D, Noller HF, Dahlberg AE. Mutations in 16S ribosomal RNA disrupt antibiotic--RNA interactions. EMBO J. 1989 Apr; 8(4):1213-6.
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  81. Moazed D, Robertson JM, Noller HF. Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA. Nature. 1988 Jul 28; 334(6180):362-4.
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  82. Stern S, Moazed D, Noller HF. Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension. Methods Enzymol. 1988; 164:481-9.
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  83. Moazed D, Noller HF. Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA. Biochimie. 1987 Aug; 69(8):879-84.
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  84. Moazed D, Noller HF. Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature. 1987 Jun 4-10; 327(6121):389-94.
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  85. Noller HF, Stern S, Moazed D, Powers T, Svensson P, Changchien LM. Studies on the architecture and function of 16S rRNA. Cold Spring Harb Symp Quant Biol. 1987; 52:695-708.
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  86. Moazed D, Noller HF. Transfer RNA shields specific nucleotides in 16S ribosomal RNA from attack by chemical probes. Cell. 1986 Dec 26; 47(6):985-94.
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  87. Moazed D, Van Stolk BJ, Douthwaite S, Noller HF. Interconversion of active and inactive 30 S ribosomal subunits is accompanied by a conformational change in the decoding region of 16 S rRNA. J Mol Biol. 1986 Oct 5; 191(3):483-93.
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  88. Moazed D, Stern S, Noller HF. Rapid chemical probing of conformation in 16 S ribosomal RNA and 30 S ribosomal subunits using primer extension. J Mol Biol. 1986 Feb 5; 187(3):399-416.
    View in: PubMed
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