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Charles Nicholas Serhan, PH.D.

TitleSimon Gelman Professor of Anaesthesia
InstitutionBrigham and Women's Hospital
DepartmentAnaesthesia
AddressHarvard Institutes of Medicine
Center for Exp. Therapeutics , HIM 829
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-5001
Fax617/525-5017

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li Y, Dalli J, Chiang N, Baron RM, Quintana C, Serhan CN. Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators. Immunity. 2013 Nov 14; 39(5):885-98.
    View in: PubMed
  2. Spite M, Clària J, Serhan CN. Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014 Jan 7; 19(1):21-36.
    View in: PubMed
  3. Xu ZZ, Liu XJ, Berta T, Park CK, Lü N, Serhan CN, Ji RR. Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. Ann Neurol. 2013 Sep; 74(3):490-5.
    View in: PubMed
  4. Orr SK, Palumbo S, Bosetti F, Mount HT, Kang JX, Greenwood CE, Ma DW, Serhan CN, Bazinet RP. Unesterified docosahexaenoic acid is protective in neuroinflammation. J Neurochem. 2013 Nov; 127(3):378-93.
    View in: PubMed
  5. Divanovic S, Dalli J, Jorge-Nebert LF, Flick LM, Gálvez-Peralta M, Boespflug ND, Stankiewicz TE, Fitzgerald JM, Somarathna M, Karp CL, Serhan CN, Nebert DW. Contributions of the Three CYP1 Monooxygenases to Pro-Inflammatory and Inflammation-Resolution Lipid Mediator Pathways. J Immunol. 2013 Sep 15; 191(6):3347-57.
    View in: PubMed
  6. Mustafa M, Zarrough A, Bolstad AI, Lygre H, Mustafa K, Hasturk H, Serhan C, Kantarci A, Van Dyke TE. Resolvin D1 protects periodontal ligament. Am J Physiol Cell Physiol. 2013 Sep; 305(6):C673-9.
    View in: PubMed
  7. Serhan CN, Chiang N. Resolution phase lipid mediators of inflammation: agonists of resolution. Curr Opin Pharmacol. 2013 Aug; 13(4):632-40.
    View in: PubMed
  8. Dalli J, Colas RA, Serhan CN. Novel n-3 Immunoresolvents: Structures and Actions. Sci Rep. 2013 Jun 5; 3:1940.
    View in: PubMed
  9. Chiang N, Shinohara M, Dalli J, Mirakaj V, Kibi M, Choi AM, Serhan CN. Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Unique Proresolving Mediator-Heme Oxygenase-1 Circuits. J Immunol. 2013 Jun 15; 190(12):6378-88.
    View in: PubMed
  10. Koltsida O, Karamnov S, Pyrillou K, Vickery T, Chairakaki AD, Tamvakopoulos C, Sideras P, Serhan CN, Andreakos E. Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. EMBO Mol Med. 2013 May; 5(5):762-75.
    View in: PubMed
  11. Winkler JW, Uddin J, Serhan CN, Petasis NA. Stereocontrolled Total Synthesis of the Potent Anti-inflammatory and Pro-resolving Lipid Mediator Resolvin D3 and Its Aspirin-Triggered 17R-Epimer. Org Lett. 2013 Apr 5; 15(7):1424-7.
    View in: PubMed
  12. Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA, Serhan CN. The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. FASEB J. 2013 Jul; 27(7):2573-83.
    View in: PubMed
  13. Li D, Hodges RR, Jiao J, Carozza RB, Shatos MA, Chiang N, Serhan CN, Dartt DA. Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. Mucosal Immunol. 2013 Nov; 6(6):1119-30.
    View in: PubMed
  14. Hsiao HM, Sapinoro RE, Thatcher TH, Croasdell A, Levy EP, Fulton RA, Olsen KC, Pollock SJ, Serhan CN, Phipps RP, Sime PJ. A novel anti-inflammatory and pro-resolving role for resolvin d1 in acute cigarette smoke-induced lung inflammation. PLoS One. 2013; 8(3):e58258.
    View in: PubMed
  15. Dalli J, Winkler JW, Colas RA, Arnardottir H, Cheng CY, Chiang N, Petasis NA, Serhan CN. Resolvin d3 and aspirin-triggered resolvin d3 are potent immunoresolvents. Chem Biol. 2013 Feb 21; 20(2):188-201.
    View in: PubMed
  16. Miyahara T, Runge S, Chatterjee A, Chen M, Mottola G, Fitzgerald JM, Serhan CN, Conte MS. D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. FASEB J. 2013 Jun; 27(6):2220-32.
    View in: PubMed
  17. Clària J, Nguyen BT, Madenci AL, Ozaki CK, Serhan CN. Diversity of lipid mediators in human adipose tissue depots. Am J Physiol Cell Physiol. 2013 Jun; 304(12):C1141-9.
    View in: PubMed
  18. Neuhofer A, Zeyda M, Mascher D, Itariu BK, Murano I, Leitner L, Hochbrugger EE, Fraisl P, Cinti S, Serhan CN, Stulnig TM. Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation. Diabetes. 2013 Jun; 62(6):1945-56.
    View in: PubMed
  19. Gao L, Faibish D, Fredman G, Herrera BS, Chiang N, Serhan CN, Van Dyke TE, Gyurko R. Resolvin E1 and Chemokine-like Receptor 1 Mediate Bone Preservation. J Immunol. 2013 Jan 15; 190(2):689-94.
    View in: PubMed
  20. Buckley CD, Gilroy DW, Serhan CN, Stockinger B, Tak PP. The resolution of inflammation. Nat Rev Immunol. 2013 Jan; 13(1):59-66.
    View in: PubMed
  21. Jones CN, Dalli J, Dimisko L, Wong E, Serhan CN, Irimia D. Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20560-5.
    View in: PubMed
  22. Recchiuti A, Serhan CN. Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation. Front Immunol. 2012; 3:298.
    View in: PubMed
  23. Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M, Cadavid A. Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids. 2012 Oct-Nov; 87(4-5):127-34.
    View in: PubMed
  24. Fredman G, Li Y, Dalli J, Chiang N, Serhan CN. Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. Sci Rep. 2012; 2:639.
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  25. Dalli J, Serhan CN. Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood. 2012 Oct 11; 120(15):e60-72.
    View in: PubMed
  26. Clària J, Dalli J, Yacoubian S, Gao F, Serhan CN. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. J Immunol. 2012 Sep 1; 189(5):2597-605.
    View in: PubMed
  27. Levy BD, Vachier I, Serhan CN. Resolution of inflammation in asthma. Clin Chest Med. 2012 Sep; 33(3):559-70.
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  28. Giera M, Ioan-Facsinay A, Toes R, Gao F, Dalli J, Deelder AM, Serhan CN, Mayboroda OA. Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS. Biochim Biophys Acta. 2012 Nov; 1821(11):1415-24.
    View in: PubMed
  29. Rogerio AP, Haworth O, Croze R, Oh SF, Uddin M, Carlo T, Pfeffer MA, Priluck R, Serhan CN, Levy BD. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. J Immunol. 2012 Aug 15; 189(4):1983-91.
    View in: PubMed
  30. Ramon S, Gao F, Serhan CN, Phipps RP. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J Immunol. 2012 Jul 15; 189(2):1036-42.
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  31. Chiang N, Fredman G, Bäckhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature. 2012 Apr 26; 484(7395):524-8.
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  32. Bazan NG, Eady TN, Khoutorova L, Atkins KD, Hong S, Lu Y, Zhang C, Jun B, Obenaus A, Fredman G, Zhu M, Winkler JW, Petasis NA, Serhan CN, Belayev L. Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol. 2012 Jul; 236(1):122-30.
    View in: PubMed
  33. Shinohara M, Mirakaj V, Serhan CN. Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome. Front Immunol. 2012; 3:81.
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  34. Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M. Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1970-8.
    View in: PubMed
  35. Oh SF, Dona M, Fredman G, Krishnamoorthy S, Irimia D, Serhan CN. Resolvin E2 formation and impact in inflammation resolution. J Immunol. 2012 May 1; 188(9):4527-34.
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  36. Krishnamoorthy S, Recchiuti A, Chiang N, Fredman G, Serhan CN. Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May; 180(5):2018-27.
    View in: PubMed
  37. Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TT, Vary JC, Hawn TR, Dunstan SJ, Farrar JJ, Thwaites GE, King MC, Serhan CN, Ramakrishnan L. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 2012 Feb 3; 148(3):434-46.
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  38. Pillai PS, Leeson S, Porter TF, Owens CD, Kim JM, Conte MS, Serhan CN, Gelman S. Chemical mediators of inflammation and resolution in post-operative abdominal aortic aneurysm patients. Inflammation. 2012 Feb; 35(1):98-113.
    View in: PubMed
  39. Ariel A, Serhan CN. New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation. Front Immunol. 2012; 3:4.
    View in: PubMed
  40. Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NA. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J. 2012 Apr; 26(4):1755-65.
    View in: PubMed
  41. Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, Coleman RA, Bornfeldt KE. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):E715-24.
    View in: PubMed
  42. Abumrad NA, Piomelli D, Yurko-Mauro K, Merrill A, Clandinin MT, Serhan CN. Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts. Adv Nutr. 2012 Jan; 3(1):60-8.
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  43. Park CK, Xu ZZ, Liu T, Lü N, Serhan CN, Ji RR. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. J Neurosci. 2011 Dec 14; 31(50):18433-8.
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  44. Yang R, Chiang N, Oh SF, Serhan CN. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. Curr Protoc Immunol. 2011 Nov; Chapter 14:Unit 14.26.
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  45. Park CK, Lü N, Xu ZZ, Liu T, Serhan CN, Ji RR. Resolving TRPV1- and TNF-a-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. J Neurosci. 2011 Oct 19; 31(42):15072-85.
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  46. Campbell EL, Serhan CN, Colgan SP. Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators. J Immunol. 2011 Oct 1; 187(7):3475-81.
    View in: PubMed
  47. Ji RR, Xu ZZ, Strichartz G, Serhan CN. Emerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci. 2011 Nov; 34(11):599-609.
    View in: PubMed
  48. Fredman G, Oh SF, Ayilavarapu S, Hasturk H, Serhan CN, Van Dyke TE. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. PLoS One. 2011; 6(9):e24422.
    View in: PubMed
  49. Bäck M, Dahlén SE, Drazen JM, Evans JF, Serhan CN, Shimizu T, Yokomizo T, Rovati GE. International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions. Pharmacol Rev. 2011 Sep; 63(3):539-84.
    View in: PubMed
  50. Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NA. Novel proresolving aspirin-triggered DHA pathway. Chem Biol. 2011 Aug 26; 18(8):976-87.
    View in: PubMed
  51. Greene ER, Huang S, Serhan CN, Panigrahy D. Regulation of inflammation in cancer by eicosanoids. Prostaglandins Other Lipid Mediat. 2011 Nov; 96(1-4):27-36.
    View in: PubMed
  52. Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev. 2011 Oct 12; 111(10):5922-43.
    View in: PubMed
  53. Fredman G, Serhan CN. Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. Biochem J. 2011 Jul 15; 437(2):185-97.
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  54. Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CN. Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. J Biol Chem. 2011 Sep 9; 286(36):31532-41.
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  55. Oh SF, Vickery TW, Serhan CN. Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. Biochim Biophys Acta. 2011 Nov; 1811(11):737-47.
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  56. Palmer CD, Mancuso CJ, Weiss JP, Serhan CN, Guinan EC, Levy O. 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. J Leukoc Biol. 2011 Sep; 90(3):459-70.
    View in: PubMed
  57. Spite M, Serhan CN. Lipid signatures of unstable atheromas: fossils or a step toward personalized lipidomics-metabolomics? Circ Cardiovasc Genet. 2011 Jun; 4(3):215-7.
    View in: PubMed
  58. Serhan CN. The resolution of inflammation: the devil in the flask and in the details. FASEB J. 2011 May; 25(5):1441-8.
    View in: PubMed
  59. Merched AJ, Serhan CN, Chan L. Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis. J Nutrigenet Nutrigenomics. 2011; 4(1):12-24.
    View in: PubMed
  60. Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN. Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol. 2011 May 15; 186(10):5543-7.
    View in: PubMed
  61. Dartt DA, Hodges RR, Li D, Shatos MA, Lashkari K, Serhan CN. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. J Immunol. 2011 Apr 1; 186(7):4455-66.
    View in: PubMed
  62. Huang L, Wang CF, Serhan CN, Strichartz G. Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. Pain. 2011 Mar; 152(3):557-65.
    View in: PubMed
  63. Oh SF, Pillai PS, Recchiuti A, Yang R, Serhan CN. Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. J Clin Invest. 2011 Feb; 121(2):569-81.
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  64. Serhan CN, Krishnamoorthy S, Recchiuti A, Chiang N. Novel anti-inflammatory--pro-resolving mediators and their receptors. Curr Top Med Chem. 2011; 11(6):629-47.
    View in: PubMed
  65. Schif-Zuck S, Gross N, Assi S, Rostoker R, Serhan CN, Ariel A. Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids. Eur J Immunol. 2011 Feb; 41(2):366-79.
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  66. Spite M, Serhan CN. Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res. 2010 Nov 12; 107(10):1170-84.
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  67. Recchiuti A, Krishnamoorthy S, Fredman G, Chiang N, Serhan CN. MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. FASEB J. 2011 Feb; 25(2):544-60.
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  68. Levy BD, Zhang QY, Bonnans C, Primo V, Reilly JJ, Perkins DL, Liang Y, Amin Arnaout M, Nikolic B, Serhan CN. The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. Prostaglandins Leukot Essent Fatty Acids. 2011 Jan-Feb; 84(1-2):43-50.
    View in: PubMed
  69. Serhan CN. Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not? Am J Pathol. 2010 Oct; 177(4):1576-91.
    View in: PubMed
  70. Ho KJ, Spite M, Owens CD, Lancero H, Kroemer AH, Pande R, Creager MA, Serhan CN, Conte MS. Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. Am J Pathol. 2010 Oct; 177(4):2116-23.
    View in: PubMed
  71. Fredman G, Van Dyke TE, Serhan CN. Resolvin E1 regulates adenosine diphosphate activation of human platelets. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):2005-13.
    View in: PubMed
  72. Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta. 2010 Dec; 1801(12):1260-73.
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  73. Norling LV, Serhan CN. Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med. 2010 Jul; 268(1):15-24.
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  74. Xu ZZ, Zhang L, Liu T, Park JY, Berta T, Yang R, Serhan CN, Ji RR. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med. 2010 May; 16(5):592-7, 1p following 597.
    View in: PubMed
  75. Bazan NG, Calandria JM, Serhan CN. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J Lipid Res. 2010 Aug; 51(8):2018-31.
    View in: PubMed
  76. Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HR. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51.
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  77. Planagumà A, Pfeffer MA, Rubin G, Croze R, Uddin M, Serhan CN, Levy BD. Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. Mucosal Immunol. 2010 May; 3(3):270-9.
    View in: PubMed
  78. Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN. Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1660-5.
    View in: PubMed
  79. Marcheselli VL, Mukherjee PK, Arita M, Hong S, Antony R, Sheets K, Winkler JW, Petasis NA, Serhan CN, Bazan NG. Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins Leukot Essent Fatty Acids. 2010 Jan; 82(1):27-34.
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  80. Ishida T, Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T. Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis. Inflamm Bowel Dis. 2010 Jan; 16(1):87-95.
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  81. Ohira T, Arita M, Omori K, Recchiuti A, Van Dyke TE, Serhan CN. Resolvin E1 receptor activation signals phosphorylation and phagocytosis. J Biol Chem. 2010 Jan 29; 285(5):3451-61.
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  82. Gleissman H, Yang R, Martinod K, Lindskog M, Serhan CN, Johnsen JI, Kogner P. Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates. FASEB J. 2010 Mar; 24(3):906-15.
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  83. Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29; 461(7268):1287-91.
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  84. Sun YP, Tjonahen E, Keledjian R, Zhu M, Yang R, Recchiuti A, Pillai PS, Petasis NA, Serhan CN. Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs. Prostaglandins Leukot Essent Fatty Acids. 2009 Nov-Dec; 81(5-6):357-66.
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  85. Serhan CN. Systems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediators. J Thromb Haemost. 2009 Jul; 7 Suppl 1:44-8.
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  86. Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM. International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev. 2009 Jun; 61(2):119-61.
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  87. El Kebir D, József L, Pan W, Wang L, Petasis NA, Serhan CN, Filep JG. 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. Am J Respir Crit Care Med. 2009 Aug 15; 180(4):311-9.
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  88. Spite M, Summers L, Porter TF, Srivastava S, Bhatnagar A, Serhan CN. Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress. Br J Pharmacol. 2009 Oct; 158(4):1062-73.
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  89. Jin Y, Arita M, Zhang Q, Saban DR, Chauhan SK, Chiang N, Serhan CN, Dana R. Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4743-52.
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  90. Zurier RB, Sun YP, George KL, Stebulis JA, Rossetti RG, Skulas A, Judge E, Serhan CN. Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4. FASEB J. 2009 May; 23(5):1503-9.
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  91. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med. 2009 Jan 16; 206(1):15-23.
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  92. Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CN. Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. J Immunol. 2008 Dec 15; 181(12):8677-87.
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  93. Serhan CN. Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov; 79(3-5):157-63.
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  94. Malawista SE, de Boisfleury Chevance A, van Damme J, Serhan CN. Tonic inhibition of chemotaxis in human plasma. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17949-54.
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  95. Chen M, Divangahi M, Gan H, Shin DS, Hong S, Lee DM, Serhan CN, Behar SM, Remold HG. Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. J Exp Med. 2008 Nov 24; 205(12):2791-801.
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  96. Herrera BS, Ohira T, Gao L, Omori K, Yang R, Zhu M, Muscara MN, Serhan CN, Van Dyke TE, Gyurko R. An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption. Br J Pharmacol. 2008 Dec; 155(8):1214-23.
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  97. Serhan CN. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J Periodontol. 2008 Aug; 79(8 Suppl):1520-6.
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  98. Haworth O, Cernadas M, Yang R, Serhan CN, Levy BD. Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol. 2008 Aug; 9(8):873-9.
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  99. Merched AJ, Ko K, Gotlinger KH, Serhan CN, Chan L. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. 2008 Oct; 22(10):3595-606.
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  100. Poulsen RC, Gotlinger KH, Serhan CN, Kruger MC. Identification of inflammatory and proresolving lipid mediators in bone marrow and their lipidomic profiles with ovariectomy and omega-3 intake. Am J Hematol. 2008 Jun; 83(6):437-45.
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  101. Dona M, Fredman G, Schwab JM, Chiang N, Arita M, Goodarzi A, Cheng G, von Andrian UH, Serhan CN. Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood. 2008 Aug 1; 112(3):848-55.
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  102. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008 May; 8(5):349-61.
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  103. Machado FS, Esper L, Dias A, Madan R, Gu Y, Hildeman D, Serhan CN, Karp CL, Aliberti J. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med. 2008 May 12; 205(5):1077-86.
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  104. Chiang N, Schwab JM, Fredman G, Kasuga K, Gelman S, Serhan CN. Anesthetics impact the resolution of inflammation. PLoS One. 2008; 3(4):e1879.
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  105. Hong S, Porter TF, Lu Y, Oh SF, Pillai PS, Serhan CN. Resolvin E1 metabolome in local inactivation during inflammation-resolution. J Immunol. 2008 Mar 1; 180(5):3512-9.
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  106. Petasis NA, Keledjian R, Sun YP, Nagulapalli KC, Tjonahen E, Yang R, Serhan CN. Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties. Bioorg Med Chem Lett. 2008 Feb 15; 18(4):1382-7.
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  107. Serhan CN, Yacoubian S, Yang R. Anti-inflammatory and proresolving lipid mediators. Annu Rev Pathol. 2008; 3:279-312.
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  108. Masoodi M, Mir AA, Petasis NA, Serhan CN, Nicolaou A. Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008; 22(2):75-83.
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  109. Haas-Stapleton EJ, Lu Y, Hong S, Arita M, Favoreto S, Nigam S, Serhan CN, Agabian N. Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. PLoS One. 2007; 2(12):e1316.
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  110. Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TE. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol. 2007 Nov 15; 179(10):7021-9.
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  111. Serhan CN, Chiang N. Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Br J Pharmacol. 2008 Mar; 153 Suppl 1:S200-15.
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  112. Yacoubian S, Serhan CN. New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. Nat Clin Pract Rheumatol. 2007 Oct; 3(10):570-9; quiz 1 p following 589.
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  113. Bannenberg G, Arita M, Serhan CN. Endogenous receptor agonists: resolving inflammation. ScientificWorldJournal. 2007; 7:1440-62.
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  114. Levy BD, Lukacs NW, Berlin AA, Schmidt B, Guilford WJ, Serhan CN, Parkinson JF. Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. FASEB J. 2007 Dec; 21(14):3877-84.
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  115. El Kebir D, József L, Khreiss T, Pan W, Petasis NA, Serhan CN, Filep JG. Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation. J Immunol. 2007 Jul 1; 179(1):616-22.
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  116. Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LE. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-73.
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  117. Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14; 447(7146):869-74.
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  118. Campbell EL, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN, Colgan SP. Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J. 2007 Oct; 21(12):3162-70.
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  119. Ashton AW, Mukherjee S, Nagajyothi FN, Huang H, Braunstein VL, Desruisseaux MS, Factor SM, Lopez L, Berman JW, Wittner M, Scherer PE, Capra V, Coffman TM, Serhan CN, Gotlinger K, Wu KK, Weiss LM, Tanowitz HB. Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. J Exp Med. 2007 Apr 16; 204(4):929-40.
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  120. Arita M, Serhan CN. [Novel chemical mediators in the resolution of inflammation]. Tanpakushitsu Kakusan Koso. 2007 Apr; 52(4):348-54.
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  121. Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol. 2007 Mar 15; 178(6):3912-7.
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  122. Ariel A, Serhan CN. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol. 2007 Apr; 28(4):176-83.
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  123. Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LA, Perretti M, Rossi AG, Wallace JL. Resolution of inflammation: state of the art, definitions and terms. FASEB J. 2007 Feb; 21(2):325-32.
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  124. Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30; 282(13):9323-34.
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  125. Svensson CI, Zattoni M, Serhan CN. Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. J Exp Med. 2007 Feb 19; 204(2):245-52.
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  126. Serhan CN, Lu Y, Hong S, Yang R. Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins. Methods Enzymol. 2007; 432:275-317.
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  127. Serhan CN. Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol. 2007; 25:101-37.
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  128. Lu Y, Hong S, Yang R, Uddin J, Gotlinger KH, Petasis NA, Serhan CN. Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms. Rapid Commun Mass Spectrom. 2007; 21(1):7-22.
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  129. Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol. 2007 Jan 1; 178(1):496-502.
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  130. Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S, Arita M, Serhan CN. Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem Biol. 2006 Nov; 13(11):1193-202.
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  131. Duffield JS, Hong S, Vaidya VS, Lu Y, Fredman G, Serhan CN, Bonventre JV. Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol. 2006 Nov 1; 177(9):5902-11.
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  132. Hong S, Lu Y, Yang R, Gotlinger KH, Petasis NA, Serhan CN. Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. J Am Soc Mass Spectrom. 2007 Jan; 18(1):128-44.
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  133. Serhan CN, Wasserman SI. The allergy archives: pioneer and milestones. The discovery and characterization of the leukotrienes. J Allergy Clin Immunol. 2006 Oct; 118(4):972-80.
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  134. Ariel A, Fredman G, Sun YP, Kantarci A, Van Dyke TE, Luster AD, Serhan CN. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol. 2006 Nov; 7(11):1209-16.
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  135. Wada K, Arita M, Nakajima A, Katayama K, Kudo C, Kamisaki Y, Serhan CN. Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation. FASEB J. 2006 Sep; 20(11):1785-92.
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  136. Chiang N, Serhan CN, Dahlén SE, Drazen JM, Hay DW, Rovati GE, Shimizu T, Yokomizo T, Brink C. The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev. 2006 Sep; 58(3):463-87.
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  137. Xia S, Lu Y, Wang J, He C, Hong S, Serhan CN, Kang JX. Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12499-504.
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  138. Hudert CA, Weylandt KH, Lu Y, Wang J, Hong S, Dignass A, Serhan CN, Kang JX. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11276-81.
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  139. Arita M, Oh SF, Chonan T, Hong S, Elangovan S, Sun YP, Uddin J, Petasis NA, Serhan CN. Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. J Biol Chem. 2006 Aug 11; 281(32):22847-54.
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  140. Schwab JM, Serhan CN. Lipoxins and new lipid mediators in the resolution of inflammation. Curr Opin Pharmacol. 2006 Aug; 6(4):414-20.
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  141. Liu W, Cao D, Oh SF, Serhan CN, Kulmacz RJ. Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun; 20(8):1097-108.
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  142. Serhan CN. Novel chemical mediators in the resolution of inflammation: resolvins and protectins. Anesthesiol Clin. 2006 Jun; 24(2):341-64.
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  143. Lu Y, Hong S, Gotlinger K, Serhan CN. Lipid mediator informatics and proteomics in inflammation resolution. ScientificWorldJournal. 2006; 6:589-614.
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  144. Serhan CN, Hong S, Lu Y. Lipid mediator informatics-lipidomics: novel pathways in mapping resolution. AAPS J. 2006; 8(2):E284-97.
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  145. Serhan CN, Gotlinger K, Hong S, Lu Y, Siegelman J, Baer T, Yang R, Colgan SP, Petasis NA. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol. 2006 Feb 1; 176(3):1848-59.
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  146. Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, Aliberti J. Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat Med. 2006 Mar; 12(3):330-4.
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  147. Chiang N, Serhan CN. New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications. Compr Ther. 2006; 32(3):150-7.
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  148. Chiang N, Serhan CN. Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators. Methods Mol Biol. 2006; 341:227-50.
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  149. Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE. RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. FASEB J. 2006 Feb; 20(2):401-3.
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  150. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol. 2005 Dec; 6(12):1191-7.
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  151. Chiang N, Hurwitz S, Ridker PM, Serhan CN. Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial. Arterioscler Thromb Vasc Biol. 2006 Feb; 26(2):e14-7.
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  152. Ariel A, Li PL, Wang W, Tang WX, Fredman G, Hong S, Gotlinger KH, Serhan CN. The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. J Biol Chem. 2005 Dec 30; 280(52):43079-86.
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  153. Lukiw WJ, Cui JG, Marcheselli VL, Bodker M, Botkjaer A, Gotlinger K, Serhan CN, Bazan NG. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest. 2005 Oct; 115(10):2774-83.
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  154. Levy BD, Hickey L, Morris AJ, Larvie M, Keledjian R, Petasis NA, Bannenberg G, Serhan CN. Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo. Br J Pharmacol. 2005 Oct; 146(3):344-51.
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  155. Chiang N, Arita M, Serhan CN. Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):163-77.
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  156. Petasis NA, Akritopoulou-Zanze I, Fokin VV, Bernasconi G, Keledjian R, Yang R, Uddin J, Nagulapalli KC, Serhan CN. Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):301-21.
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  157. Serhan CN. Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):141-62.
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  158. Arita M, Clish CB, Serhan CN. The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids. Biochem Biophys Res Commun. 2005 Dec 9; 338(1):149-57.
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  159. Hong S, Tjonahen E, Morgan EL, Lu Y, Serhan CN, Rowley AF. Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. Prostaglandins Other Lipid Mediat. 2005 Dec; 78(1-4):107-16.
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  160. Bafica A, Scanga CA, Serhan C, Machado F, White S, Sher A, Aliberti J. Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. J Clin Invest. 2005 Jun; 115(6):1601-6.
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  161. Arita M, Yoshida M, Hong S, Tjonahen E, Glickman JN, Petasis NA, Blumberg RS, Serhan CN. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7671-6.
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  162. Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science. 2005 Jun 10; 308(5728):1626-9.
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  163. Bannenberg GL, Chiang N, Ariel A, Arita M, Tjonahen E, Gotlinger KH, Hong S, Serhan CN. Molecular circuits of resolution: formation and actions of resolvins and protectins. J Immunol. 2005 Apr 1; 174(7):4345-55.
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  164. Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med. 2005 Mar 7; 201(5):713-22.
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  165. Serhan CN. Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. Curr Opin Clin Nutr Metab Care. 2005 Mar; 8(2):115-21.
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  166. Devchand PR, Schmidt BA, Primo VC, Zhang QY, Arnaout MA, Serhan CN, Nikolic B. A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. FASEB J. 2005 Feb; 19(2):203-10.
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  167. Lu Y, Hong S, Tjonahen E, Serhan CN. Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators. J Lipid Res. 2005 Apr; 46(4):790-802.
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  168. Serhan CN. Novel omega -- 3-derived local mediators in anti-inflammation and resolution. Pharmacol Ther. 2005 Jan; 105(1):7-21.
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  169. Serhan CN. Clues for new therapeutics in osteoporosis and periodontal disease: new roles for lipoxygenases? Expert Opin Ther Targets. 2004 Dec; 8(6):643-52.
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  170. Chiang N, Serhan CN. Aspirin triggers formation of anti-inflammatory mediators: New mechanism for an old drug. Discov Med. 2004 Dec; 4(24):470-5.
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  171. Serhan CN. Mediator lipidomics. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):4-14.
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  172. Serhan CN, Arita M, Hong S, Gotlinger K. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids. 2004 Nov; 39(11):1125-32.
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  173. Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CN. Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15178-83.
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  174. Andersson P, Serhan CN, Petasis NA, Palmblad J. Interactions between lipoxin A4, the stable analogue 16-phenoxy-lipoxin A4 and leukotriene B4 in cytokine generation by human monocytes. Scand J Immunol. 2004 Sep; 60(3):249-56.
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  175. Serhan CN. A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution. Histochem Cell Biol. 2004 Oct; 122(4):305-21.
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  176. Bannenberg G, Moussignac RL, Gronert K, Devchand PR, Schmidt BA, Guilford WJ, Bauman JG, Subramanyam B, Perez HD, Parkinson JF, Serhan CN. Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration. Br J Pharmacol. 2004 Sep; 143(1):43-52.
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  177. Ohira T, Bannenberg G, Arita M, Takahashi M, Ge Q, Van Dyke TE, Stahl GL, Serhan CN, Badwey JA. A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils. J Immunol. 2004 Aug 1; 173(3):2091-8.
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  178. Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci U S A. 2004 Jun 1; 101(22):8491-6.
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  179. Serhan CN. Clues for new therapeutics in osteoporosis. N Engl J Med. 2004 Apr 29; 350(18):1902-3.
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  180. Serhan CN, Gotlinger K, Hong S, Arita M. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. Prostaglandins Other Lipid Mediat. 2004 Apr; 73(3-4):155-72.
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  181. Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T. International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. Pharmacol Rev. 2004 Mar; 56(1):149-57.
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  182. Bannenberg GL, Aliberti J, Hong S, Sher A, Serhan C. Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis. J Exp Med. 2004 Feb 16; 199(4):515-23.
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  183. Vance RE, Hong S, Gronert K, Serhan CN, Mekalanos JJ. The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2135-9.
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  184. Pasche B, Serhan CN. Is C-reactive protein an inflammation opsonin that signals colon cancer risk? JAMA. 2004 Feb 4; 291(5):623-4.
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  185. Gronert K, Kantarci A, Levy BD, Clish CB, Odparlik S, Hasturk H, Badwey JA, Colgan SP, Van Dyke TE, Serhan CN. A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage. J Immunol. 2004 Feb 1; 172(3):1856-61.
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  186. Serhan CN, Chiang N. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics. Rheum Dis Clin North Am. 2004 Feb; 30(1):69-95.
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  187. Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, Van Dyke TE. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003 Dec 15; 171(12):6856-65.
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  188. Schwab JM, Schluesener HJ, Meyermann R, Serhan CN. COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics? Prostaglandins Leukot Essent Fatty Acids. 2003 Nov; 69(5):339-43.
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  189. Jain A, Batista EL, Serhan C, Stahl GL, Van Dyke TE. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun. 2003 Oct; 71(10):6012-8.
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  190. Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJ. Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J Biol Chem. 2003 Dec 12; 278(50):49874-81.
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  191. Marcheselli VL, Hong S, Lukiw WJ, Tian XH, Gronert K, Musto A, Hardy M, Gimenez JM, Chiang N, Serhan CN, Bazan NG. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem. 2003 Oct 31; 278(44):43807-17.
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  192. Levy O, Canny G, Serhan CN, Colgan SP. Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia. Biochem Soc Trans. 2003 Aug; 31(Pt 4):795-800.
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  193. Serhan CN, Levy B. Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8609-11.
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  194. Ariel A, Chiang N, Arita M, Petasis NA, Serhan CN. Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells. J Immunol. 2003 Jun 15; 170(12):6266-72.
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  195. Chiang N, Takano T, Arita M, Watanabe S, Serhan CN. A novel rat lipoxin A4 receptor that is conserved in structure and function. Br J Pharmacol. 2003 May; 139(1):89-98.
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  196. Levy BD, Serhan CN. Exploring new approaches to the treatment of asthma: potential roles for lipoxins and aspirin-triggered lipid mediators. Drugs Today (Barc). 2003 May; 39(5):373-84.
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  197. Devchand PR, Arita M, Hong S, Bannenberg G, Moussignac RL, Gronert K, Serhan CN. Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense. FASEB J. 2003 Apr; 17(6):652-9.
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  198. Fierro IM, Colgan SP, Bernasconi G, Petasis NA, Clish CB, Arita M, Serhan CN. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. J Immunol. 2003 Mar 1; 170(5):2688-94.
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  199. Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T. International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev. 2003 Mar; 55(1):195-227.
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  200. Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem. 2003 Apr 25; 278(17):14677-87.
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  201. Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res. 2003 Feb; 82(2):82-90.
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  202. Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt B, Szczeklik W, Drazen JM, Serhan CN. Lipoxins and aspirin-triggered lipoxins in airway responses. Adv Exp Med Biol. 2003; 525:19-23.
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  203. Serhan CN, Levy B. Novel pathways and endogenous mediators in anti-inflammation and resolution. Chem Immunol Allergy. 2003; 83:115-45.
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  204. Aliberti J, Serhan C, Sher A. Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J Exp Med. 2002 Nov 4; 196(9):1253-62.
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  205. Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G, Moussignac RL. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med. 2002 Oct 21; 196(8):1025-37.
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  206. Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CN. Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med. 2002 Nov; 8(11):1296-302.
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  207. József L, Zouki C, Petasis NA, Serhan CN, Filep JG. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20):13266-71.
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  208. Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt BA, Szczeklik W, Drazen JM, Serhan CN. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med. 2002 Sep; 8(9):1018-23.
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  209. Serhan CN. Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolution. Prostaglandins Other Lipid Mediat. 2002 Aug; 68-69:433-55.
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  210. Ichinose F, Ullrich R, Sapirstein A, Jones RC, Bonventre JV, Serhan CN, Bloch KD, Zapol WM. Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction. J Clin Invest. 2002 Jun; 109(11):1493-500.
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  211. Levy BD, Serhan CN. Polyisoprenyl phosphates: natural antiinflammatory lipid signals. Cell Mol Life Sci. 2002 May; 59(5):729-41.
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  212. Canny G, Levy O, Furuta GT, Narravula-Alipati S, Sisson RB, Serhan CN, Colgan SP. Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3902-7.
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  213. Fierro IM, Kutok JL, Serhan CN. Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). J Pharmacol Exp Ther. 2002 Feb; 300(2):385-92.
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  214. Resnati M, Pallavicini I, Wang JM, Oppenheim J, Serhan CN, Romano M, Blasi F. The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. Proc Natl Acad Sci U S A. 2002 Feb 5; 99(3):1359-64.
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  215. Serhan CN, Chiang N. Lipid-derived mediators in endogenous anti-inflammation and resolution: lipoxins and aspirin-triggered 15-epi-lipoxins. ScientificWorldJournal. 2002 Jan 22; 2:169-204.
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  216. Zhang YY, Walker JL, Huang A, Keaney JF, Clish CB, Serhan CN, Loscalzo J. Expression of 5-lipoxygenase in pulmonary artery endothelial cells. Biochem J. 2002 Jan 15; 361(Pt 2):267-76.
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  217. Filep JG, Zouki C, Petasis NA, Hachicha M, Serhan CN. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion. Adv Exp Med Biol. 2002; 507:223-8.
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  218. Titos E, Chiang N, Serhan CN, Romano M, Gaya J, Pueyo G, Clària J. Aspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells. Adv Exp Med Biol. 2002; 507:199-209.
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  219. Bandeira-Melo C, Diaz BL, Cordeiro RS, Jose PJ, Serhan CN, Martins MA, Bozza PT. Inhibition of allergen-induced eosinophil migration by lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4. Adv Exp Med Biol. 2002; 507:211-6.
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  220. Aliberti J, Hieny S, Reis e Sousa C, Serhan CN, Sher A. Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat Immunol. 2002 Jan; 3(1):76-82.
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  221. Clish CB, Sun YP, Serhan CN. Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase. Biochem Biophys Res Commun. 2001 Nov 9; 288(4):868-74.
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  222. Qiu FH, Devchand PR, Wada K, Serhan CN. Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. FASEB J. 2001 Dec; 15(14):2736-8.
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  223. Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN. Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol. 2001 Jul; 2(7):612-9.
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  224. Serhan CN, Oliw E. Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways. J Clin Invest. 2001 Jun; 107(12):1481-9.
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  225. Serhan CN, Devchand PR. Novel antiinflammatory targets for asthma. A role for PPARgamma? Am J Respir Cell Mol Biol. 2001 Jun; 24(6):658-61.
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  226. Fierro IM, Serhan CN. Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins. Braz J Med Biol Res. 2001 May; 34(5):555-66.
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  227. Serhan CN, Fierro IM, Chiang N, Pouliot M. Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. J Immunol. 2001 Mar 15; 166(6):3650-4.
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  228. Wada K, Qiu FH, Stahl GL, Serhan CN. Inosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediators. J Hematother Stem Cell Res. 2001 Feb; 10(1):75-9.
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  229. Serhan CN. Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side. Arch Immunol Ther Exp (Warsz). 2001; 49(3):177-88.
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  230. Gronert K, Martinsson-Niskanen T, Ravasi S, Chiang N, Serhan CN. Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. Am J Pathol. 2001 Jan; 158(1):3-9.
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  231. Serhan CN, Clish CB, Brannon J, Colgan SP, Gronert K, Chiang N. Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. J Physiol Pharmacol. 2000 Dec; 51(4 Pt 1):643-54.
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  232. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med. 2000 Oct 16; 192(8):1197-204.
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  233. Serhan CN, Clish CB. Aspirin triggered lipid mediators: novel inhibitors of leucocyte trafficking. Thorax. 2000 Oct; 55 Suppl 2:S10-2.
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  234. Levy BD, Serhan CN. Polyisoprenyl phosphate signaling: topography in human neutrophils. Biochem Biophys Res Commun. 2000 Sep 7; 275(3):739-45.
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  235. Clish CB, Levy BD, Chiang N, Tai HH, Serhan CN. Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. J Biol Chem. 2000 Aug 18; 275(33):25372-80.
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  236. Serhan CN, Prescott SM. The scent of a phagocyte: Advances on leukotriene b(4) receptors. J Exp Med. 2000 Aug 7; 192(3):F5-8.
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  237. Serhan CN. Preventing injury from within, using selective cPLA2 inhibitors. Nat Immunol. 2000 Jul; 1(1):13-5.
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  238. Sanak M, Levy BD, Clish CB, Chiang N, Gronert K, Mastalerz L, Serhan CN, Szczeklik A. Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. Eur Respir J. 2000 Jul; 16(1):44-9.
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  239. Pouliot M, Clish CB, Petasis NA, Van Dyke TE, Serhan CN. Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry. 2000 Apr 25; 39(16):4761-8.
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  240. Qiu FH, Wada K, Stahl GL, Serhan CN. IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4267-72.
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  241. Chiang N, Fierro IM, Gronert K, Serhan CN. Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. J Exp Med. 2000 Apr 3; 191(7):1197-208.
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  242. Clish CB, Gronert K, Serhan CN. Local and systemic delivery of an aspirin-triggered lipoxin stable analog inhibits neutrophil trafficking. Ann N Y Acad Sci. 2000 Apr; 905:274-8.
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  243. Levy BD, Serhan CN. A novel polyisoprenyl phosphate signaling cascade in human neutrophils. Ann N Y Acad Sci. 2000 Apr; 905:69-80.
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  244. Bandeira-Melo C, Bozza PT, Diaz BL, Cordeiro RS, Jose PJ, Martins MA, Serhan CN. Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking. J Immunol. 2000 Mar 1; 164(5):2267-71.
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  245. Serhan CN, Takano T, Chiang N, Gronert K, Clish CB. Formation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability. Am J Respir Crit Care Med. 2000 Feb; 161(2 Pt 2):S95-S101.
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  246. Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan CN, Spiegelman BM. A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation. J Biol Chem. 2000 Jan 21; 275(3):1873-7.
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  247. Bandeira-Melo C, Serra MF, Diaz BL, Cordeiro RS, Silva PM, Lenzi HL, Bakhle YS, Serhan CN, Martins MA. Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. J Immunol. 2000 Jan 15; 164(2):1029-36.
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  248. Serhan CN, Levy BD, Clish CB, Gronert K, Chiang N. Lipoxins, aspirin-triggered 15-epi-lipoxin stable analogs and their receptors in anti-inflammation: a window for therapeutic opportunity. Ernst Schering Res Found Workshop. 2000; (31):143-85.
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  249. Filep JG, Zouki C, Petasis NA, Hachicha M, Serhan CN. Anti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. Blood. 1999 Dec 15; 94(12):4132-42.
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  250. Titos E, Chiang N, Serhan CN, Romano M, Gaya J, Pueyo G, Clària J. Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). Am J Physiol. 1999 Nov; 277(5 Pt 1):C870-7.
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  251. Pouliot M, Serhan CN. Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-alpha-initiated neutrophil responses and trafficking: novel regulators of a cytokine-chemokine axis relevant to periodontal diseases. J Periodontal Res. 1999 Oct; 34(7):370-3.
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  252. Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CN. Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J Clin Invest. 1999 Aug; 104(3):309-16.
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  253. Clish CB, O'Brien JA, Gronert K, Stahl GL, Petasis NA, Serhan CN. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. Proc Natl Acad Sci U S A. 1999 Jul 6; 96(14):8247-52.
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  254. Hachicha M, Pouliot M, Petasis NA, Serhan CN. Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. J Exp Med. 1999 Jun 21; 189(12):1923-30.
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  255. Levy BD, Fokin VV, Clark JM, Wakelam MJ, Petasis NA, Serhan CN. Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. FASEB J. 1999 May; 13(8):903-11.
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  256. Gewirtz AT, Fokin VV, Petasis NA, Serhan CN, Madara JL. LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation. Am J Physiol. 1999 Apr; 276(4 Pt 1):C988-94.
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  257. Serhan CN, Takano T, Gronert K, Chiang N, Clish CB. Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators. Clin Chem Lab Med. 1999 Mar; 37(3):299-309.
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  258. Serhan CN, Takano T, Clish CB, Gronert K, Petasis N. Aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogs inhibit neutrophil-mediated changes in vascular permeability. Adv Exp Med Biol. 1999; 469:287-93.
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  259. Gronert K, Clish CB, Romano M, Serhan CN. Transcellular regulation of eicosanoid biosynthesis. Methods Mol Biol. 1999; 120:119-44.
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  260. Serhan CN, Takano T, Maddox JF. Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways. Adv Exp Med Biol. 1999; 447:133-49.
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  261. Chiang N, Takano T, Clish CB, Petasis NA, Tai HH, Serhan CN. Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA. J Pharmacol Exp Ther. 1998 Nov; 287(2):779-90.
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  262. Gewirtz AT, McCormick B, Neish AS, Petasis NA, Gronert K, Serhan CN, Madara JL. Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. J Clin Invest. 1998 May 1; 101(9):1860-9.
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  263. Gronert K, Gewirtz A, Madara JL, Serhan CN. Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. J Exp Med. 1998 Apr 20; 187(8):1285-94.
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  264. Gronert K, Colgan SP, Serhan CN. Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. J Pharmacol Exp Ther. 1998 Apr; 285(1):252-61.
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  265. Maddox JF, Colgan SP, Clish CB, Petasis NA, Fokin VV, Serhan CN. Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity. FASEB J. 1998 Apr; 12(6):487-94.
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  266. Takano T, Clish CB, Gronert K, Petasis N, Serhan CN. Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues. J Clin Invest. 1998 Feb 15; 101(4):819-26.
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  267. D'Andrea AD, Serhan CN. Relieving the Itch. Nat Genet. 1998 Feb; 18(2):97-9.
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  268. Levy BD, Petasis NA, Serhan CN. Polyisoprenyl phosphates in intracellular signalling. Nature. 1997 Oct 30; 389(6654):985-90.
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  269. Scalia R, Gefen J, Petasis NA, Serhan CN, Lefer AM. Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin. Proc Natl Acad Sci U S A. 1997 Sep 2; 94(18):9967-72.
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  270. Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J Exp Med. 1997 May 5; 185(9):1693-704.
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  271. Serhan CN, Drazen JM. Antiinflammatory potential of lipoxygenase-derived eicosanoids: a molecular switch at 5 and 15 positions? J Clin Invest. 1997 Mar 15; 99(6):1147-8.
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  272. Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CN. Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. J Biol Chem. 1997 Mar 14; 272(11):6972-8.
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  273. Serhan CN. Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity? Prostaglandins. 1997 Feb; 53(2):107-37.
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  274. Brady HR, Papayianni A, Serhan CN. Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. Adv Exp Med Biol. 1997; 400B:631-40.
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  275. Serhan CN. Lipoxin metabolism by human promyelocytic leukemia (HL-60) cells. Adv Exp Med Biol. 1997; 400B:641-6.
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  276. Bowden LA, Fiore S, Restall CJ, Serhan CN, Rowley AF. Characterisation of the binding of leukotriene B4 to macrophages of the rainbow trout Oncorhynchus mykiss. J Exp Biol. 1997 Jan; 200(Pt 1):155-60.
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  277. Levy BD, Drazen JM, Serhan CN. Agonist-induced lipoxin A4 generation in vitro and in aspirin-sensitive asthmatics: detection by a novel lipoxin A4-ELISA. Adv Exp Med Biol. 1997; 400B:611-5.
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  278. Serhan CN. Inflammation. Signalling the fat controller. Nature. 1996 Nov 7; 384(6604):23-4.
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  279. Clària J, Lee MH, Serhan CN. Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Mol Med. 1996 Sep; 2(5):583-96.
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  280. Romano M, Maddox JF, Serhan CN. Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization. J Immunol. 1996 Sep 1; 157(5):2149-54.
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  281. Serhan CN, Haeggström JZ, Leslie CC. Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J. 1996 Aug; 10(10):1147-58.
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  282. Papayianni A, Serhan CN, Brady HR. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. J Immunol. 1996 Mar 15; 156(6):2264-72.
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  283. Maddox JF, Serhan CN. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. J Exp Med. 1996 Jan 1; 183(1):137-46.
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  284. Brady HR, Serhan CN. Lipoxins: putative braking signals in host defense, inflammation and hypersensitivity. Curr Opin Nephrol Hypertens. 1996 Jan; 5(1):20-7.
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  285. Fiore S, Serhan CN. Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. Biochemistry. 1995 Dec 26; 34(51):16678-86.
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  286. Datta YH, Romano M, Jacobson BC, Golan DE, Serhan CN, Ewenstein BM. Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. Circulation. 1995 Dec 1; 92(11):3304-11.
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  287. Serhan CN, Maddox JF, Petasis NA, Akritopoulou-Zanze I, Papayianni A, Brady HR, Colgan SP, Madara JL. Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry. 1995 Nov 7; 34(44):14609-15.
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  288. Clària J, Serhan CN. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9475-9.
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  289. Serhan CN, Romano M. Lipoxin biosynthesis and actions: role of the human platelet LX-synthase. J Lipid Mediat Cell Signal. 1995 Oct; 12(2-3):293-306.
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  290. Brady HR, Papayianni A, Serhan CN. Potential vascular roles for lipoxins in the "stop programs" of host defense and inflammation. Trends Cardiovasc Med. 1995 Sep-Oct; 5(5):186-92.
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  291. Papayianni A, Serhan CN, Phillips ML, Rennke HG, Brady HR. Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis. Kidney Int. 1995 May; 47(5):1295-302.
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  292. Serhan CN. Leukocyte transmigration, chemotaxis, and oxygenated derivatives of arachidonic acid: when is chirality important? Am J Respir Cell Mol Biol. 1995 Mar; 12(3):251-3.
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  293. Simchowitz L, Fiore S, Serhan CN. Carrier-mediated transport of lipoxin A4 in human neutrophils. Am J Physiol. 1994 Dec; 267(6 Pt 1):C1525-34.
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  294. Serhan CN, Fiore S, Levy BD. Cell-cell interactions in lipoxin generation and characterization of lipoxin A4 receptors. Ann N Y Acad Sci. 1994 Nov 15; 744:166-80.
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  295. Sri Kantha S, Matsumura H, Kubo E, Kawase K, Takahata R, Serhan CN, Hayaishi O. Effects of prostaglandin D2, lipoxins and leukotrienes on sleep and brain temperature of rats. Prostaglandins Leukot Essent Fatty Acids. 1994 Aug; 51(2):87-93.
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  296. Fiore S, Maddox JF, Perez HD, Serhan CN. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J Exp Med. 1994 Jul 1; 180(1):253-60.
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  297. McManus M, Serhan C, Jackson P, Strange K. Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. Am J Physiol. 1994 Jul; 267(1 Pt 1):C266-71.
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  298. Serhan CN. Lipoxin biosynthesis and its impact in inflammatory and vascular events. Biochim Biophys Acta. 1994 Apr 14; 1212(1):1-25.
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  299. Brady HR, Papayianni A, Serhan CN. Leukocyte adhesion promotes biosynthesis of lipoxygenase products by transcellular routes. Kidney Int Suppl. 1994 Feb; 45:S90-7.
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  300. Rowley AF, Lloyd-Evans P, Barrow SE, Serhan CN. Lipoxin biosynthesis by trout macrophages involves the formation of epoxide intermediates. Biochemistry. 1994 Feb 1; 33(4):856-63.
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  301. Takata S, Matsubara M, Allen PG, Janmey PA, Serhan CN, Brady HR. Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium. J Clin Invest. 1994 Feb; 93(2):499-508.
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  302. Serhan CN, Fiore S. Lipoxin recognition sites of human neutrophils. Adv Prostaglandin Thromboxane Leukot Res. 1994; 22:317-26.
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  303. Serhan CN. Eicosanoids in leukocyte function. Curr Opin Hematol. 1994 Jan; 1(1):69-77.
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  304. Levy BD, Bertram S, Tai HH, Israel E, Fischer A, Drazen JM, Serhan CN. Agonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA. Lipids. 1993 Dec; 28(12):1047-53.
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  305. Romano M, Chen XS, Takahashi Y, Yamamoto S, Funk CD, Serhan CN. Lipoxin synthase activity of human platelet 12-lipoxygenase. Biochem J. 1993 Nov 15; 296 ( Pt 1):127-33.
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  306. Levy BD, Romano M, Chapman HA, Reilly JJ, Drazen J, Serhan CN. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. J Clin Invest. 1993 Sep; 92(3):1572-9.
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  307. Colgan SP, Serhan CN, Parkos CA, Delp-Archer C, Madara JL. Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. J Clin Invest. 1993 Jul; 92(1):75-82.
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  308. Serhan CN, Fiore S, Brezinski DA, Lynch S. Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: conversion to novel 15-oxo and dihydro products. Biochemistry. 1993 Jun 29; 32(25):6313-9.
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  309. Fiore S, Romano M, Reardon EM, Serhan CN. Induction of functional lipoxin A4 receptors in HL-60 cells. Blood. 1993 Jun 15; 81(12):3395-403.
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  310. Serhan CN. Cell-cell interactions in the generation of eicosanoids: charting the routes and products of transcellular biosynthesis. J Lab Clin Med. 1993 Mar; 121(3):372-4.
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  311. Romano M, Serhan CN. Lipoxin generation by permeabilized human platelets. Biochemistry. 1992 Sep 8; 31(35):8269-77.
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  312. Katoh T, Takahashi K, DeBoer DK, Serhan CN, Badr KF. Renal hemodynamic actions of lipoxins in rats: a comparative physiological study. Am J Physiol. 1992 Sep; 263(3 Pt 2):F436-42.
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  313. Fiore S, Ryeom SW, Weller PF, Serhan CN. Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils. J Biol Chem. 1992 Aug 15; 267(23):16168-76.
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  314. Brady HR, Serhan CN. Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by antibodies against CD18 and L-selectin. Biochem Biophys Res Commun. 1992 Aug 14; 186(3):1307-14.
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  315. Roll FJ, Perez HD, Serhan CN. Characterization of a novel arachidonic acid-derived neutrophil chemoattractant. Biochem Biophys Res Commun. 1992 Jul 15; 186(1):269-76.
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  316. Brezinski DA, Nesto RW, Serhan CN. Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy. Circulation. 1992 Jul; 86(1):56-63.
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  317. Sheppard KA, Greenberg SM, Funk CD, Romano M, Serhan CN. Lipoxin generation by human megakaryocyte-induced 12-lipoxygenase. Biochim Biophys Acta. 1992 Jan 13; 1133(2):223-34.
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  318. Brezinski DA, Serhan CN. Characterization of lipoxins by combined gas chromatography and electron-capture negative ion chemical ionization mass spectrometry: formation of lipoxin A4 by stimulated human whole blood. Biol Mass Spectrom. 1991 Feb; 20(2):45-52.
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  319. Serhan CN. Lipoxins: eicosanoids carrying intra- and intercellular messages. J Bioenerg Biomembr. 1991 Feb; 23(1):105-22.
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  320. Fiore S, Brezinski ME, Sheppard KA, Serhan CN. The lipoxin biosynthetic circuit and their actions with human neutrophils. Adv Exp Med Biol. 1991; 314:109-32.
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  321. Serhan CN, Brezinski ME. Selective incorporation of 15-HETE in phosphatidylinositol: agonist-induced deacylation and transformation of stored HETEs by human neutrophils. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:105-8.
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  322. Brady HR, Denton MD, Brenner BM, Serhan CN. Neutrophil adhesion to glomerular mesangial cells: regulation by lipoxygenase-derived eicosanoids. Adv Exp Med Biol. 1991; 314:347-59.
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  323. Liu LX, Serhan CN, Weller PF. Formation of cyclooxygenase-derived eicosanoids by a parasitic intravascular nematode. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21B:509-12.
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  324. Fiore S, Nigam S, Serhan CN. Lipoxins trigger the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21B:553-6.
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  325. Fiore S, Romano M, Serhan CN. Lipoxin and leukotriene production during receptor-activated interactions between human platelets and cytokine-primed neutrophils. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:93-6.
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  326. Brady HR, Persson U, Ballermann BJ, Brenner BM, Serhan CN. Leukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxins. Am J Physiol. 1990 Nov; 259(5 Pt 2):F809-15.
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  327. Fiore S, Serhan CN. Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. J Exp Med. 1990 Nov 1; 172(5):1451-7.
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  328. Liu LX, Serhan CN, Weller PF. Intravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids. J Exp Med. 1990 Sep 1; 172(3):993-6.
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  329. Brezinski ME, Serhan CN. Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6248-52.
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  330. Lee TH, Crea AE, Gant V, Spur BW, Marron BE, Nicolaou KC, Reardon E, Brezinski M, Serhan CN. Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases. Am Rev Respir Dis. 1990 Jun; 141(6):1453-8.
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  331. Nigam S, Fiore S, Luscinskas FW, Serhan CN. Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. J Cell Physiol. 1990 Jun; 143(3):512-23.
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  332. Serhan CN, Sheppard KA. Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro. J Clin Invest. 1990 Mar; 85(3):772-80.
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  333. Fiore S, Nicolaou KC, Caulfield T, Kataoka H, Serhan CN. Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils. Biochem J. 1990 Feb 15; 266(1):25-31.
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  334. Luscinskas FW, Nicolaou KC, Webber SE, Veale CA, Gimbrone MA, Serhan CN. Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils. Biochem Pharmacol. 1990 Jan 15; 39(2):355-65.
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  335. Serhan CN. High-performance liquid chromatography separation and determination of lipoxins. Methods Enzymol. 1990; 187:167-75.
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  336. Serhan CN, Sheppard KA, Fiore S. Lipoxin formation: evaluation of the role and actions of leukotriene A4. Adv Prostaglandin Thromboxane Leukot Res. 1990; 20:54-62.
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  337. Serhan CN. On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE. Biochim Biophys Acta. 1989 Aug 8; 1004(2):158-68.
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  338. Nicolaou KC, Marron BE, Veale CA, Webber SE, Dahlén SE, Samuelsson B, Serhan CN. Identification of a novel 7-cis-11-trans-lipoxin A4 generated by human neutrophils: total synthesis, spasmogenic activities and comparison with other geometric isomers of lipoxins A4 and B4. Biochim Biophys Acta. 1989 May 15; 1003(1):44-53.
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  339. Badr KF, DeBoer DK, Schwartzberg M, Serhan CN. Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor. Proc Natl Acad Sci U S A. 1989 May; 86(9):3438-42.
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  340. Fiore S, Serhan CN. Phospholipid bilayers enhance the stability of leukotriene A4 and epoxytetraenes: stabilization of eicosanoids by liposomes. Biochem Biophys Res Commun. 1989 Mar 15; 159(2):477-81.
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  341. Brezinski ME, Gimbrone MA, Nicolaou KC, Serhan CN. Lipoxins stimulate prostacyclin generation by human endothelial cells. FEBS Lett. 1989 Mar 13; 245(1-2):167-72.
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  342. Serhan CN, Reardon E. 15-Hydroxyeicosatetraenoic acid inhibits superoxide anion generation by human neutrophils: relationship to lipoxin production. Free Radic Res Commun. 1989; 7(3-6):341-5.
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  343. Dahlén SE, Veale CA, Webber SE, Marron BE, Nicolaou KC, Serhan CN. Pharmacodynamics of lipoxin A4 in airway smooth muscle. Agents Actions. 1989 Jan; 26(1-2):93-5.
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  344. Serhan CN. On the generation of lipoxins and novel related compounds by human neutrophils: relationship to leukotriene production. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:116-21.
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  345. Stern A, Serhan CN. Human red cells enhance the formation of 5-lipoxygenase-derived products by neutrophils. Free Radic Res Commun. 1989; 7(3-6):335-9.
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  346. Brasseur R, Deleers M, Ruysschaert JM, Samuelsson B, Serhan CN. Conformational analysis of lipoxin A, lipoxin B and their trans-isomers. Biochim Biophys Acta. 1988 May 22; 960(2):245-52.
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  347. Serhan CN, Samuelsson B. Lipoxins: a new series of eicosanoids (biosynthesis, stereochemistry, and biological activities). Adv Exp Med Biol. 1988; 229:1-14.
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  348. Dahlén SE, Franzén L, Raud J, Serhan CN, Westlund P, Wikström E, Björck T, Matsuda H, Webber SE, Veale CA, et al. Actions of lipoxin A4 and related compounds in smooth muscle preparations and on the microcirculation in vivo. Adv Exp Med Biol. 1988; 229:107-30.
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  349. Brasseur R, Serhan CN, Deleers M. Computed conformational analysis of lipoxins and their ionic complexes. Adv Exp Med Biol. 1988; 229:93-106.
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  350. Samuelsson B, Dahlén SE, Lindgren JA, Rouzer CA, Serhan CN. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science. 1987 Sep 4; 237(4819):1171-6.
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  351. Dahlén SE, Raud J, Serhan CN, Björk J, Samuelsson B. Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo. Acta Physiol Scand. 1987 Aug; 130(4):643-7.
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  352. Serhan CN, Wong PY, Samuelsson B. Nomenclature of lipoxins and related compounds derived from arachidonic acid and eicosapentaenoic acid. Prostaglandins. 1987 Aug; 34(2):201-4.
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  353. Serhan CN, Hirsch U, Palmblad J, Samuelsson B. Formation of lipoxin A by granulocytes from eosinophilic donors. FEBS Lett. 1987 Jun 15; 217(2):242-6.
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  354. Palmblad J, Gyllenhammar H, Ringertz B, Serhan CN, Samuelsson B, Nicolaou KC. The effects of lipoxin A and lipoxin B on functional responses of human granulocytes. Biochem Biophys Res Commun. 1987 May 29; 145(1):168-75.
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  355. Badr KF, Serhan CN, Nicolaou KC, Samuelsson B. The action of lipoxin-A on glomerular microcirculatory dynamics in the rat. Biochem Biophys Res Commun. 1987 May 29; 145(1):408-14.
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  356. Lam BK, Serhan CN, Samuelsson B, Wong PY. A phospholipase A2 isoenzyme provokes lipoxin B formation from endogenous sources of arachidonic acid in porcine leukocytes. Biochem Biophys Res Commun. 1987 Apr 14; 144(1):123-31.
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  357. Serhan CN, Nicolaou KC, Webber SE, Veale CA, Haeggström J, Puustinen TJ, Samuelsson B. Stereochemistry and biosynthesis of lipoxins. Adv Prostaglandin Thromboxane Leukot Res. 1987; 17A:90-3.
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  358. Ramstedt U, Serhan CN, Nicolaou KC, Webber SE, Wigzell H, Samuelsson B. Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action. J Immunol. 1987 Jan 1; 138(1):266-70.
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  359. Serhan CN, Nicolaou KC, Webber SE, Veale CA, Dahlén SE, Puustinen TJ, Samuelsson B. Lipoxin A. Stereochemistry and biosynthesis. J Biol Chem. 1986 Dec 15; 261(35):16340-5.
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  360. Puustinen T, Webber SE, Nicolaou KC, Haeggström J, Serhan CN, Samuelsson B. Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase. FEBS Lett. 1986 Oct 20; 207(1):127-32.
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  361. Serhan CN, Hamberg M, Samuelsson B, Morris J, Wishka DG. On the stereochemistry and biosynthesis of lipoxin B. Proc Natl Acad Sci U S A. 1986 Apr; 83(7):1983-7.
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  362. Hansson A, Serhan CN, Haeggström J, Ingelman-Sundberg M, Samuelsson B. Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. Biochem Biophys Res Commun. 1986 Feb 13; 134(3):1215-22.
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  363. Serhan CN, Hamberg M, Ramstedt U, Samuelsson B. Lipoxins: stereochemistry, biosynthesis and biological activities. Adv Prostaglandin Thromboxane Leukot Res. 1986; 16:83-97.
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  364. Patarroyo M, Beatty PG, Serhan CN, Gahmberg CG. Identification of a cell-surface glycoprotein mediating adhesion in human granulocytes. Scand J Immunol. 1985 Dec; 22(6):619-31.
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  365. Ramstedt U, Ng J, Wigzell H, Serhan CN, Samuelsson B. Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding. J Immunol. 1985 Nov; 135(5):3434-8.
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  366. Lundberg U, Serhan CN, Samuelsson B. Appearance of an arachidonic acid 15-lipoxygenase pathway upon differentiation of the human promyelocytic cell-line HL-60. FEBS Lett. 1985 Jun 3; 185(1):14-8.
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  367. Aisen PS, Haines KA, Given W, Abramson SB, Pras M, Serhan C, Hamberg M, Samuelsson B, Weissmann G. Circulating hydroxy fatty acids in familial Mediterranean fever. Proc Natl Acad Sci U S A. 1985 Feb; 82(4):1232-6.
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  368. Samuelsson B, Hammarström S, Hamberg M, Serhan CN. Structural determination of leukotrienes and lipoxins. Adv Prostaglandin Thromboxane Leukot Res. 1985; 14:45-71.
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  369. Serhan CN, Fahlstadius P, Dahlén SE, Hamberg M, Samuelsson B. Biosynthesis and biological activities of lipoxins. Adv Prostaglandin Thromboxane Leukot Res. 1985; 15:163-6.
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  370. Radmark O, Serhan C, Hamberg M, Lundberg U, Ennis MD, Bundy GL, Oglesby TD, Aristoff PA, Harrison AW, Slomp G, et al. Stereochemistry, total synthesis, and biological activity of 14,15-dihydroxy-5,8,10,12-eicosatetraenoic acid. J Biol Chem. 1984 Nov 10; 259(21):13011-6.
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  371. Ramstedt U, Serhan CN, Lundberg U, Wigzell H, Samuelsson B. Inhibition of human natural killer cell activity by (14R,15S)-14,15-dihydroxy-5Z,8Z,10E,12E- icosatetraenoic acid. Proc Natl Acad Sci U S A. 1984 Nov; 81(22):6914-8.
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  372. Marcus AJ, Safier LB, Broekman MJ, Ullman HL, Islam N, Sorrell TC, Serhan CN, Weissmann G, Oglesby TD, Gorman RR. Production of metabolic products of arachidonic acid during cell-cell interactions. J Allergy Clin Immunol. 1984 Sep; 74(3 Pt 2):338-42.
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  373. Serhan CN, Hamberg M, Samuelsson B. Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5335-9.
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  374. Serhan CN, Lundberg U, Weissmann G, Samuelsson B. Formation of leukotrienes and hydroxy acids by human neutrophils and platelets exposed to monosodium urate. Prostaglandins. 1984 Apr; 27(4):563-81.
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  375. Serhan CN, Hamberg M, Samuelsson B. Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. Biochem Biophys Res Commun. 1984 Feb 14; 118(3):943-9.
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  376. Serhan CN, Lundberg U, Lindgren JA, Weissmann G, Samuelsson B. Formation of leukotriene C4 by human leukocytes exposed to monosodium urate crystals. FEBS Lett. 1984 Feb 13; 167(1):109-12.
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  377. Weissmann G, Serhan C, Korchak HM, Smolen JE. Mechanisms of mediator release from neutrophils. Adv Exp Med Biol. 1984; 172:527-52.
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  378. Marcus AJ, Broekman MJ, Safier LB, Ullman HL, Islam N, Serhan CN, Weissmann G. Production of arachidonic acid lipoxygenase products during platelet-neutrophil interactions. Clin Physiol Biochem. 1984; 2(2-3):78-83.
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  379. Serhan CN, Broekman MJ, Korchak HM, Smolen JE, Marcus AJ, Weissmann G. Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils. Relationship to calcium mobilization, aggregation and superoxide radical generation. Biochim Biophys Acta. 1983 Jun 2; 762(3):420-8.
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  380. Serhan CN, Smolen JE, Korchak HM, Weissmann G. Leukotriene B4 is a complete secretagogue in human neutrophils: Ca2+ translocation in liposomes and kinetics of neutrophil activation. Adv Prostaglandin Thromboxane Leukot Res. 1983; 11:53-63.
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  381. Serhan CN, Broekman MJ, Korchak HM, Marcus AJ, Weissmann G. Endogenous phospholipid metabolism in stimulated neutrophils differential activation by FMLP and PMA. Biochem Biophys Res Commun. 1982 Aug; 107(3):951-8.
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  382. Serhan CN, Radin A, Smolen JE, Korchak H, Samuelsson B, Weissmann G. Leukotriene B4 is a complete secretagogue in human neutrophils: a kinetic analysis. Biochem Biophys Res Commun. 1982 Aug; 107(3):1006-12.
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  383. Serhan CN, Fridovich J, Goetzl EJ, Dunham PB, Weissmann G. Leukotriene B4 and phosphatidic acid are calcium ionophores. Studies employing arsenazo III in liposomes. J Biol Chem. 1982 May 10; 257(9):4746-52.
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  384. Weissmann G, Serhan C, Korchak HM, Smolen JE. Neutrophils: release of mediators of inflammation with special reference to rheumatoid arthritis. Ann N Y Acad Sci. 1982; 389:11-24.
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  385. Korchak HM, Serhan CN, Weissmann G. Activation of the human neutrophil: the roles of lipid remodeling and intracellular calcium. Monogr Pathol. 1982; (23):83-93.
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  386. Weissmann G, Serhan C, Smolen JE, Korchak HM, Friedman R, Kaplan HB. Stimulus-secretion coupling in the human neutrophil: the role of phosphatidic acid and oxidized fatty acids in the translocation of calcium. Adv Prostaglandin Thromboxane Leukot Res. 1982; 9:259-72.
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  387. Serhan C, Anderson P, Goodman E, Dunham P, Weissmann G. Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes. J Biol Chem. 1981 Mar 25; 256(6):2736-41.
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  388. Weissmann G, Serhan C, Korchak HM, Smolen JE, Broekman MJ, Marcus AJ. Neutrophils generate phosphatidic acid, an "endogenous calcium ionophore" before releasing mediators of inflammation. Trans Assoc Am Physicians. 1981; 94:357-65.
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  389. Serhan CN, Korchak HM, Weissmann G. PGBX, a prostagandin derivative, mimics the action of the calcium ionophore A23187 on human neutrophils. J Immunol. 1980 Nov; 125(5):2020-4.
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  390. Weissmann G, Anderson P, Serhan C, Samuelsson E, Goodman E. A general method, employing arsenazo III in liposomes, for study of calcium ionophores: results with A23187 and prostaglandins. Proc Natl Acad Sci U S A. 1980 Mar; 77(3):1506-10.
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