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Jeanne Frances Duffy, PH.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham & Women's Hospital
Sleep Medicine
221 Longwood Ave
Boston MA 02115
Phone617/732-7995
Fax617/732-4015

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lim AS, Chang AM, Shulman JM, Raj T, Chibnik LB, Cain SW, Rothamel K, Benoist C, Myers AJ, Czeisler CA, Buchman AS, Bennett DA, Duffy JF, Saper CB, De Jager PL. A common polymorphism near PER1 and the timing of human behavioral rhythms. Ann Neurol. 2012 Sep; 72(3):324-34.
    View in: PubMed
  2. Pomplun M, Silva EJ, Ronda JM, Cain SW, Münch MY, Czeisler CA, Duffy JF. The effects of circadian phase, time awake, and imposed sleep restriction on performing complex visual tasks: evidence from comparative visual search. J Vis. 2012; 12(7).
    View in: PubMed
  3. Klerman EB, Wang W, Duffy JF, Dijk DJ, Czeisler CA, Kronauer RE. Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep. Neurobiol Aging. 2013 Jan; 34(1):309-18.
    View in: PubMed
  4. Chang AM, Santhi N, St Hilaire M, Gronfier C, Bradstreet DS, Duffy JF, Lockley SW, Kronauer RE, Czeisler CA. Human responses to bright light of different durations. J Physiol. 2012 Jul 1; 590(Pt 13):3103-12.
    View in: PubMed
  5. Buxton OM, Cain SW, O'Connor SP, Porter JH, Duffy JF, Wang W, Czeisler CA, Shea SA. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med. 2012 Apr 11; 4(129):129ra43.
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  6. Pullman RE, Roepke SE, Duffy JF. Laboratory validation of an in-home method for assessing circadian phase using dim light melatonin onset (DLMO). Sleep Med. 2012 Jun; 13(6):703-6.
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  7. Dijk DJ, Duffy JF, Silva EJ, Shanahan TL, Boivin DB, Czeisler CA. Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS One. 2012; 7(2):e30037.
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  8. Chang AM, Buch AM, Bradstreet DS, Klements DJ, Duffy JF. Human diurnal preference and circadian rhythmicity are not associated with the CLOCK 3111C/T gene polymorphism. J Biol Rhythms. 2011 Jun; 26(3):276-9.
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  9. Münch M, Scheuermaier KD, Zhang R, Dunne SP, Guzik AM, Silva EJ, Ronda JM, Duffy JF. Effects on subjective and objective alertness and sleep in response to evening light exposure in older subjects. Behav Brain Res. 2011 Oct 31; 224(2):272-8.
    View in: PubMed
  10. Duffy JF, Cain SW, Chang AM, Phillips AJ, Münch MY, Gronfier C, Wyatt JK, Dijk DJ, Wright KP, Czeisler CA. Sex difference in the near-24-hour intrinsic period of the human circadian timing system. Proc Natl Acad Sci U S A. 2011 Sep 13; 108 Suppl 3:15602-8.
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  11. Cain SW, Silva EJ, Chang AM, Ronda JM, Duffy JF. One night of sleep deprivation affects reaction time, but not interference or facilitation in a Stroop task. Brain Cogn. 2011 Jun; 76(1):37-42.
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  12. Scheuermaier K, Meyers M, Surprise M, Loughlin KR, Duffy JF. Reciprocal relationship between age-related sleep disruption and urological symptoms. BJU Int. 2011 Mar; 107(6):871-3.
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  13. Duffy JF, Lowe AS, Silva EJ, Winkelman JW. Periodic limb movements in sleep exhibit a circadian rhythm that is maximal in the late evening/early night. Sleep Med. 2011 Jan; 12(1):83-8.
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  14. Cain SW, Dennison CF, Zeitzer JM, Guzik AM, Khalsa SB, Santhi N, Schoen MW, Czeisler CA, Duffy JF. Sex differences in phase angle of entrainment and melatonin amplitude in humans. J Biol Rhythms. 2010 Aug; 25(4):288-96.
    View in: PubMed
  15. Silva EJ, Wang W, Ronda JM, Wyatt JK, Duffy JF. Circadian and wake-dependent influences on subjective sleepiness, cognitive throughput, and reaction time performance in older and young adults. Sleep. 2010 Apr; 33(4):481-90.
    View in: PubMed
  16. Scheuermaier K, Laffan AM, Duffy JF. Light exposure patterns in healthy older and young adults. J Biol Rhythms. 2010 Apr; 25(2):113-22.
    View in: PubMed
  17. Münch M, Silva EJ, Ronda JM, Czeisler CA, Duffy JF. EEG sleep spectra in older adults across all circadian phases during NREM sleep. Sleep. 2010 Mar; 33(3):389-401.
    View in: PubMed
  18. Lee JH, Wang W, Silva EJ, Chang AM, Scheuermaier KD, Cain SW, Duffy JF. Neurobehavioral performance in young adults living on a 28-h day for 6 weeks. Sleep. 2009 Jul; 32(7):905-13.
    View in: PubMed
  19. O'Donnell D, Silva EJ, Münch M, Ronda JM, Wang W, Duffy JF. Comparison of subjective and objective assessments of sleep in healthy older subjects without sleep complaints. J Sleep Res. 2009 Jun; 18(2):254-63.
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  20. Duffy JF, Willson HJ, Wang W, Czeisler CA. Healthy older adults better tolerate sleep deprivation than young adults. J Am Geriatr Soc. 2009 Jul; 57(7):1245-51.
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  21. Silva EJ, Duffy JF. Sleep inertia varies with circadian phase and sleep stage in older adults. Behav Neurosci. 2008 Aug; 122(4):928-35.
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  22. Pavlova MK, Duffy JF, Shea SA. Polysomnographic respiratory abnormalities in asymptomatic individuals. Sleep. 2008 Feb; 31(2):241-8.
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  23. Cain SW, Rimmer DW, Duffy JF, Czeisler CA. Exercise distributed across day and night does not alter circadian period in humans. J Biol Rhythms. 2007 Dec; 22(6):534-41.
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  24. Santhi N, Horowitz TS, Duffy JF, Czeisler CA. Acute sleep deprivation and circadian misalignment associated with transition onto the first night of work impairs visual selective attention. PLoS One. 2007; 2(11):e1233.
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  25. Zeitzer JM, Duffy JF, Lockley SW, Dijk DJ, Czeisler CA. Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake. Sleep. 2007 Nov; 30(11):1437-43.
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  26. Willson HJ, Ellis J, Guzik AM, Czeisler CA, Duffy JF. Healthy older adults have fewer attentional failures than young adults during extended wakefulness. Sleep. 2007; 30:in press.
  27. Scheuermaier K, Guzik AM, Row J, Munch M, Loughlin KR, Duffy JF. Urinary symptoms are related with sleep complaints and daytime sleepiness in healthy older people. Sleep. 2007; 30:in press.
  28. Silva EJ, Czeisler CA, Duffy JF. Effects of sleep inertia on subjective sleepiness and performance in older subjects. Sleep. 2007; 30:in press.
  29. Cain SW, Duffy JF, Czeisler CA. Exercise distributed across day and night does not alter circadian period. Sleep. 2007; 30:in press.
  30. Münch MY, Cain SW, Duffy JF. Biological Rhythms Workshop IC: sleep and rhythms. Cold Spring Harb Symp Quant Biol. 2007; 72:35-46.
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  31. Kuhlman SJ, Mackey SR, Duffy JF. Biological Rhythms Workshop I: introduction to chronobiology. Cold Spring Harb Symp Quant Biol. 2007; 72:1-6.
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  32. Duffy JF, Zeitzer JM, Czeisler CA. Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects. Neurobiol Aging. 2007 May; 28(5):799-807.
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  33. Scheuermaier K, Laffan AM, Duffy JF. Light exposure patterns in healthy older people living in New England, USA. J Sleep Res. 2006; 15:94.
  34. Santhi N, Duffy JF, Gronfier C, Lockley SW, Czeisler CA. Moderate intensity room light can entrain the circadian pacemaker to a non-24-h day. J Sleep Res. 2006; 15:54.
  35. Hares J, Nguyen VT, Wright Jr. KP, Czeisler CA, Loughlin KR, Duffy JF. Age-related difference in circadian rhythm of urine output under constant conditions. J Sleep Res. 2006; 15:182-183.
  36. Duffy JF. Increased sleep disruption, reduced sleepiness in older subjects? Sleep. 2005 Nov; 28(11):1358-9.
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  37. Santhi N, Duffy JF, Horowitz TS, Czeisler CA. Scheduling of sleep/darkness affects the circadian phase of night shift workers. Neurosci Lett. 2005 Aug 26; 384(3):316-20.
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  38. Duffy JF, Wright KP. Entrainment of the human circadian system by light. J Biol Rhythms. 2005 Aug; 20(4):326-38.
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  39. Zeitzer JM, Khalsa SB, Boivin DB, Duffy JF, Shanahan TL, Kronauer RE, Czeisler CA. Temporal dynamics of late-night photic stimulation of the human circadian timing system. Am J Physiol Regul Integr Comp Physiol. 2005 Sep; 289(3):R839-44.
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  40. Wright KP, Gronfier C, Duffy JF, Czeisler CA. Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans. J Biol Rhythms. 2005 Apr; 20(2):168-77.
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  41. Duffy JF, Lowe ASW, Winkelman JW, Czeisler CA. Peak circadian occurrence of PLMS during the biological nighttime. Sleep. 2005; 28:A275.
  42. Klerman EB, Davis JB, Duffy JF, Dijk DJ, Kronauer RE. Older people awaken more frequently but fall back asleep at the same rate as younger people. Sleep. 2004 Jun 15; 27(4):793-8.
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  43. Duffy JF. Shift work and aging: Roles of sleep and circadian rhythms. Clinics in Occupational and Environmental Medicine. 2003; 3:311-332.
  44. Klerman EB, Gershengorn HB, Duffy JF, Kronauer RE. Comparisons of the variability of three markers of the human circadian pacemaker. J Biol Rhythms. 2002 Apr; 17(2):181-93.
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  45. Khalsa SB, Conroy DA, Duffy JF, Czeisler CA, Dijk DJ. Sleep- and circadian-dependent modulation of REM density. J Sleep Res. 2002 Mar; 11(1):53-9.
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  46. Duffy JF, Zeitzer JM, Rimmer DW, Klerman EB, Dijk DJ, Czeisler CA. Peak of circadian melatonin rhythm occurs later within the sleep of older subjects. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E297-303.
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  47. Duffy JF, Dijk DJ. Getting through to circadian oscillators: why use constant routines? J Biol Rhythms. 2002 Feb; 17(1):4-13.
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  48. Duffy JF, Czeisler CA. Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans. Neurosci Lett. 2002 Feb 1; 318(3):117-20.
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  49. Duffy JF, Czeisler CA. Circadian rhythms. Ekerdt DJ, editors. Macmillan Encyclopedia of Aging. 2002.
  50. Grundleger CS, Rogacz S, Duffy JF. Circadian rhythms of core body temperature and plasma cortisol in anovulatory women. Sleep. 2002; 25:A309-310.
  51. Dijk DJ, Duffy JF, Czeisler CA. Age-related increase in awakenings: impaired consolidation of nonREM sleep at all circadian phases. Sleep. 2001 Aug 1; 24(5):565-77.
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  52. Duffy JF, Rimmer DW, Czeisler CA. Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase. Behav Neurosci. 2001 Aug; 115(4):895-9.
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  53. Klerman EB, Zeitzer JM, Duffy JF, Khalsa SB, Czeisler CA. Absence of an increase in the duration of the circadian melatonin secretory episode in totally blind human subjects. J Clin Endocrinol Metab. 2001 Jul; 86(7):3166-70.
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  54. Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. Circadian phase resetting in older people by ocular bright light exposure. J Investig Med. 2001 Jan; 49(1):30-40.
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  55. The timing of the human circadian clock is accurately represented by the core body temperature rhythm following phase shifts to a three-cycle light stimulus near the critical zone. J Biol Rhythms. 2000 Dec; 15(6):524-30.
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  56. Rimmer DW, Boivin DB, Shanahan TL, Kronauer RE, Duffy JF, Czeisler CA. Dynamic resetting of the human circadian pacemaker by intermittent bright light. Am J Physiol Regul Integr Comp Physiol. 2000 Nov; 279(5):R1574-9.
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  57. Czeisler CA, Dijk DJ, Kronauer RE, Brown EN, Duffy JF, Allan JS, Shanahan TL, Rimmer DW, Ronda JM, Mitchell JF, Silva EJ, Emens JS. Is there an intrinsic period of the circadian clock? Response. Science. 2000 May 19; 288(5469):1174-5.
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  58. Dijk DJ, Duffy JF, Czeisler CA. Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep. Chronobiol Int. 2000 May; 17(3):285-311.
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  59. Duffy JF. The early bird vs. the night owl. Do differences in circadian timing define our sleep preferences?. ADVANCE for Managers of Respiratory Care. 2000; 9:10-11.
  60. Zeitzer JM, Daniels JE, Duffy JF, Klerman EB, Shanahan TL, Dijk DJ, Czeisler CA. Do plasma melatonin concentrations decline with age? Am J Med. 1999 Nov; 107(5):432-6.
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  61. Duffy JF, Viswanathan N, Davis FC. Free-running circadian period does not shorten with age in female Syrian hamsters. Neurosci Lett. 1999 Aug 20; 271(2):77-80.
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  62. Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW, Ronda JM, Silva EJ, Allan JS, Emens JS, Dijk DJ, Kronauer RE. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science. 1999 Jun 25; 284(5423):2177-81.
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  63. Shanahan TL, Kronauer RE, Duffy JF, Williams GH, Czeisler CA. Melatonin rhythm observed throughout a three-cycle bright-light stimulus designed to reset the human circadian pacemaker. J Biol Rhythms. 1999 Jun; 14(3):237-53.
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  64. Dijk DJ, Duffy JF, Riel E, Shanahan TL, Czeisler CA. Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms. J Physiol. 1999 Apr 15; 516 ( Pt 2):611-27.
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  65. Dijk DJ, Duffy JF. Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics. Ann Med. 1999 Apr; 31(2):130-40.
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  66. Duffy JF, Dijk DJ, Hall EF, Czeisler CA. Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people. J Investig Med. 1999 Mar; 47(3):141-50.
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  67. Duffy JF, Dijk DJ, Klerman EB, Czeisler CA. Later endogenous circadian temperature nadir relative to an earlier wake time in older people. Am J Physiol. 1998 Nov; 275(5 Pt 2):R1478-87.
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  68. Duffy JF. Age-related changes in circadian rhythms in the Syrian hamster (Mesocricetus auratus) and the human. 1998.
  69. Dijk DJ, Shanahan TL, Duffy JF, Ronda JM, Czeisler CA. Variation of electroencephalographic activity during non-rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans. J Physiol. 1997 Dec 15; 505 ( Pt 3):851-8.
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  70. Jewett ME, Rimmer DW, Duffy JF, Klerman EB, Kronauer RE, Czeisler CA. Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients. Am J Physiol. 1997 Nov; 273(5 Pt 2):R1800-9.
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  71. Boivin DB, Czeisler CA, Dijk DJ, Duffy JF, Folkard S, Minors DS, Totterdell P, Waterhouse JM. Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects. Arch Gen Psychiatry. 1997 Feb; 54(2):145-52.
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  72. Duffy JF, Kronauer RE, Czeisler CA. Phase-shifting human circadian rhythms: influence of sleep timing, social contact and light exposure. J Physiol. 1996 Aug 15; 495 ( Pt 1):289-97.
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  73. Waldstreicher J, Duffy JF, Brown EN, Rogacz S, Allan JS, Czeisler CA. Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels- a clinical research center study. J Clin Endocrinol Metab. 1996 Apr; 81(4):1483-7.
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  74. Boivin DB, Duffy JF, Kronauer RE, Czeisler CA. Dose-response relationships for resetting of human circadian clock by light. Nature. 1996 Feb 8; 379(6565):540-2.
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  75. Boivin DB, Duffy JF, Kronauer RE, Czeisler CA. Sensitivity of the human circadian pacemaker to moderately bright light. J Biol Rhythms. 1994; 9(3-4):315-31.
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  76. Czeisler CA, Dijk DJ, Duffy JF. Entrained phase of the circadian pacemaker serves to stabilize alertness and performance throughout the habitual waking day. Ogilvie RD, Harsh JR, editors. Sleep Onset. Normal and Abnormal Processes. 1994; 134-136.
  77. Duffy JF, Czeisler CA. Assessment of endogenous circadian period in an individual whose temperature phase is delayed with respect to his habitual sleep-wake schedule. J Sleep Res. 1994; 23:490.
  78. Duffy JF. Constant routine. Carskadon M, Rechtschaffen A, Richardson G, Roth T, Siegel J, editors. Encyclopedia of Sleep and Dreaming. 1993; 134-136.
  79. Czeisler CA, Dumont M, Duffy JF, Steinberg JD, Richardson GS, Brown EN, Sánchez R, Ríos CD, Ronda JM. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet. 1992 Oct 17; 340(8825):933-6.
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  80. Dijk DJ, Duffy JF, Czeisler CA. Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance. J Sleep Res. 1992 Jun; 1(2):112-7.
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  81. Johnson MP, Duffy JF, Dijk DJ, Ronda JM, Dyal CM, Czeisler CA. Short-term memory, alertness and performance: a reappraisal of their relationship to body temperature. J Sleep Res. 1992 Mar; 1(1):24-9.
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  82. Czeisler CA, Chiasera AJ, Duffy JF. Research on sleep, circadian rhythms and aging: applications to manned spaceflight. Exp Gerontol. 1991; 26(2-3):217-32.
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  83. Czeisler CA, Johnson MP, Duffy JF, Brown EN, Ronda JM, Kronauer RE. Exposure to bright light and darkness to treat physiologic maladaptation to night work. N Engl J Med. 1990 May 3; 322(18):1253-9.
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  84. Czeisler CA, Rogacz S, Duffy JF. Reproductive function in women: Circadian interaction. Naftolin F, Gurmann JN, DeCheney AH, Sarrel PM, editors. Cardiovascular and Neurologic Function and Ovarian Secretions. 1990; 239-247.
  85. Czeisler CA, Duffy JF, Kronauer RE. Treatment of physiologic maladaptation to night work. Response. N Engl J Med. 1990; 323:918-919.
  86. Duffy JF, Shanahan TL, Czeisler CA. Phase-shifting effect of indirect (ceiling-mounted) bright light exposure on the human circadian pacemaker. Abstracts, 2nd Meeting of the Society for Research on Biological Rhythms. 1990; 38.
  87. Czeisler CA, Kronauer RE, Allan JS, Duffy JF, Jewett ME, Brown EN, Ronda JM. Bright light induction of strong (type 0) resetting of the human circadian pacemaker. Science. 1989 Jun 16; 244(4910):1328-33.
    View in: PubMed
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